Exploration of the Effect of Icariin on Nude Mice with Lung Cancer Bone Metastasis via the OPG/RANKL/RANK System
Comput Math Methods Med. 2022 May 28;2022:2011625. doi: 10.1155/2022/2011625. eCollection 2022.ABSTRACTEpimedium is a traditional Chinese medicine that is most commonly prescribed by practitioners of Chinese medicine for the clinical treatment of malignant tumor bone metastasis. The main component of Epimedium is icariin (ICA). Studies have shown that ICA inhibits bone resorption of osteoclasts through the OPG/RANKL/RANK signaling pathway. Osteoclasts are the only cells in the body that have a bone-destroying capability. The OPG/RANKL/RANK system consists of cytokines that play major roles in osteoclast formation. Therefor...
Source: Computational and Mathematical Methods in Medicine - June 7, 2022 Category: Statistics Authors: Zhao Ruilian Gao Ying Shen Hongmei Guo Lihua Source Type: research
Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats
Bone marrow adipose tissue has brown fat characteristics. Several studies have demonstrated that total flavonoids of Epimedium (TFE) could prevent bone loss and reduce the white adiposity in bone marrow induced by ovariectomy (OVX) in rats. However, the effects of TFE on marrow brown fat in OVX rats remain unclear. In this word, we addressed this question expected to provide a new target for preventing and treating osteoporosis. Thirty-six 3-month-old female Sprague-Dawley rats were equally divided into Sham controls, OVX controls, and OVX treated with TFE. Chemical shift coding magnetic resonance was performed to detect m...
Source: Frontiers in Endocrinology - June 6, 2022 Category: Endocrinology Source Type: research
A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide
Int J Biol Macromol. 2022 May 16:S0141-8130(22)01057-1. doi: 10.1016/j.ijbiomac.2022.05.087. Online ahead of print.ABSTRACTCarbohydrate polymers with unique chemical composition, molecular weight and functional chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such as plant polysaccharides exhibit advantages of biodegradability, ease of modification, low immunogenicity and low toxicity. They can be conjugated, cross-linked or functionally modified, and then used as nanocarrier materials. Polysaccharide drug delivery system can avoid the phagocytosis of the reticuloendothelial system, pre...
Source: International Journal of Biological Macromolecules - May 19, 2022 Category: Biochemistry Authors: Hexin Gong Weinan Li Jialin Sun Li Jia Qingxia Guan Yuyan Guo Yanhong Wang Source Type: research
A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide
Int J Biol Macromol. 2022 May 16:S0141-8130(22)01057-1. doi: 10.1016/j.ijbiomac.2022.05.087. Online ahead of print.ABSTRACTCarbohydrate polymers with unique chemical composition, molecular weight and functional chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such as plant polysaccharides exhibit advantages of biodegradability, ease of modification, low immunogenicity and low toxicity. They can be conjugated, cross-linked or functionally modified, and then used as nanocarrier materials. Polysaccharide drug delivery system can avoid the phagocytosis of the reticuloendothelial system, pre...
Source: International Journal of Biological Macromolecules - May 19, 2022 Category: Biochemistry Authors: Hexin Gong Weinan Li Jialin Sun Li Jia Qingxia Guan Yuyan Guo Yanhong Wang Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
Icariin attenuates ischemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signaling pathway in rats
This article is protected by copyright. All rights reserved.PMID:35451526 | DOI:10.1111/1440-1681.13645 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 22, 2022 Category: Drugs & Pharmacology Authors: Jie Zheng Yuling Liao Yuanyuan Xu Zhentao Mo Source Type: research
The mechanism of Epimedium in the treatment of coronary atherosclerotic heart disease based on network pharmacology, molecular docking, and in vitro studies
CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. (2) In vitro studies confirmed that Epimedium extract can treat CAD by upregulating PI3K, Akt and P-Akt protein expression and downregulating IL-6 protein expression in SD rat cardiomyocytes.PMID:35442463 | DOI:10.26355/eurrev_202204_28482 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 20, 2022 Category: Drugs & Pharmacology Authors: G Xin Y Yuedong S Xuemei M Chenhan Z Meng Z Chenbo G Ning W Xindong Source Type: research
The mechanism of Epimedium in the treatment of coronary atherosclerotic heart disease based on network pharmacology, molecular docking, and in vitro studies
CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. (2) In vitro studies confirmed that Epimedium extract can treat CAD by upregulating PI3K, Akt and P-Akt protein expression and downregulating IL-6 protein expression in SD rat cardiomyocytes.PMID:35442463 | DOI:10.26355/eurrev_202204_28482 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 20, 2022 Category: Drugs & Pharmacology Authors: G Xin Y Yuedong S Xuemei M Chenhan Z Meng Z Chenbo G Ning W Xindong Source Type: research
The mechanism of Epimedium in the treatment of coronary atherosclerotic heart disease based on network pharmacology, molecular docking, and in vitro studies
CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. (2) In vitro studies confirmed that Epimedium extract can treat CAD by upregulating PI3K, Akt and P-Akt protein expression and downregulating IL-6 protein expression in SD rat cardiomyocytes.PMID:35442463 | DOI:10.26355/eurrev_202204_28482 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 20, 2022 Category: Drugs & Pharmacology Authors: G Xin Y Yuedong S Xuemei M Chenhan Z Meng Z Chenbo G Ning W Xindong Source Type: research
