Pyrroloquinoline quinone delays inflammaging induced by TNF- α through the p16/p21 and Jagged1 signalling pathways.
Pyrroloquinoline quinone delays inflammaging induced by TNF-α through the p16/p21 and Jagged1 signalling pathways. Clin Exp Pharmacol Physiol. 2019 Sep 14;: Authors: Hao J, Ni X, Giunta S, Wu J, Shuang X, Xu K, Li R, Zhang W, Xia S Abstract Previous studies on the longevity effect of pyrroloquinoline quinine (PQQ) on nematode worms have revealed that PQQ can enhance the antioxidant capacity of nematode worms, thus extending the lifespan of the worms. The induction and development of cellular senescence are closely connected with inflammatory reactions. The aim of this study was to determine the ...
Source: Clinical and Experimental Pharmacology and Physiology - September 14, 2019 Category: Drugs & Pharmacology Authors: Hao J, Ni X, Giunta S, Wu J, Shuang X, Xu K, Li R, Zhang W, Xia S Tags: Clin Exp Pharmacol Physiol Source Type: research

Effects of nitric oxide on apoptosis and voltage-gated calcium channels in human cardiac myofibroblasts.
Abstract We characterised the voltage-gated Ca2+ channels (VGCCs) in human cardiac fibroblasts (HCFs) and myofibroblasts (HCMFs) and investigated the effects of nitric oxide (NO) on apoptosis and on these channels. Western blotting and immunofluorescence analyses show that α-smooth muscle actin (a myofibroblast marker) was markedly expressed in passage (P) 12-15 but not in P4 HCF cells, whereas calponin (a fibroblast marker) was expressed only in P4 cells. CaV 1.2 (L-type) and CaV 3.3 (T-type) of VGCCs were highly expressed in P12-15 cells, but only weak CaV 2.3 (R-type) expression was identified in P4 cells...
Source: Clinical and Experimental Pharmacology and Physiology - September 13, 2019 Category: Drugs & Pharmacology Authors: Bae H, Taeho K, Lim I Tags: Clin Exp Pharmacol Physiol Source Type: research

KIF2 mediates the neuroprotection in cerebral ischemia injury by affecting NF- κB pathway.
In conclusion, we demonstrate that KIF2 could mediate the neuroprotection in cerebral I/R injury by inhibiting activation of NF-κB pathway. This might provide a novel therapeutic target for cerebral I/R injury. PMID: 31514228 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - September 12, 2019 Category: Drugs & Pharmacology Authors: Wang J, Chen J, Chen J, Liu X, Yang H, Liu J, He A, Gao X, Xin Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Short- and long-term effects of maternal dyslipidemia on blood pressure and baroreflex sensitivity in male rat offspring.
This study was designed to investigate the short- and long-term effects of maternal dyslipidemia on blood pressure (BP) and baroreflex control in male rat offspring. Animals were obtained from mothers who received a dyslipidemic (DLP, n = 7) or control (CTL, n = 7) diet during pregnancy and lactation. At 30 and 90 days of age, arterial pressure (AP), heart rate (HR) and baroreflex function were evaluated. In addition, spectral analysis of the systolic AP, diastolic AP, mean AP, HR, and spontaneous baroreflex were assessed. Data were expressed as mean ± SEM and student t-test was used for comparison among groups, being considered p
Source: Clinical and Experimental Pharmacology and Physiology - September 11, 2019 Category: Drugs & Pharmacology Authors: de Araújo EV, Carneiro Dos Santos LA, Speretta GFF, de Araújo Henriques Ferreira G, de Luna Freire MO, de Santana DF, Carvalho-Galvão A, Campos Cruz J, da Costa Silva JH, de Andrade Braga V, de Brito Alves JL Tags: Clin Exp Pharmacol Physiol Source Type: research

Glycyrrhizin treatment ameliorates posttraumatic stress disorder-like behaviors and restores circadian oscillation of intracranial serotonin.
This article is protected by copyright. All rights reserved. PMID: 31494960 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - September 8, 2019 Category: Drugs & Pharmacology Authors: Lai S, Shi L, Jiang Z, Lin Z Tags: Clin Exp Pharmacol Physiol Source Type: research

The vascular endothelium plays a role in insulin action.
Abstract The endocrine system relies on the vasculature for delivery of hormones throughout the body, and the capillary microvasculature is the site where the hormones cross from the blood into the target tissue. Once considered an inert wall, various studies have now highlighted the functions of the capillary endothelium to regulate transport and therefore affect or maintain the interstitial environment. The role of the capillary may be clear in areas where there is a continuous endothelium, yet there also appears to be a role of endothelial cells in tissues with a sinusoidal structure. Here we focused on the mos...
Source: Clinical and Experimental Pharmacology and Physiology - September 3, 2019 Category: Drugs & Pharmacology Authors: Kolka CM Tags: Clin Exp Pharmacol Physiol Source Type: research

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy.
This article is protected by copyright. All rights reserved. PMID: 31469913 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 30, 2019 Category: Drugs & Pharmacology Authors: Fisher JJ, Bartho LA, Perkins AV, Holland OJ Tags: Clin Exp Pharmacol Physiol Source Type: research

Effect of chronic intermittent hypobaric hypoxia on heart rate variability in conscious rats.
This article is protected by copyright. All rights reserved. PMID: 31454428 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 27, 2019 Category: Drugs & Pharmacology Authors: Shi ZJ, Cheng M, Liu YC, Fan XR, Zhang Y, Wei Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Effect of placental growth factor in models of experimental preeclampsia and trophoblast invasion.
This article is protected by copyright. All rights reserved. PMID: 31452230 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 26, 2019 Category: Drugs & Pharmacology Authors: Chau K, Bobek G, Xu B, Stait-Gardner T, Price W, Hennessy A, Makris A Tags: Clin Exp Pharmacol Physiol Source Type: research

Increased inward rectifier K+ current of coronary artery smooth muscle cells in spontaneously hypertensive rats; partial compensation of the attenuated endothelium-dependent relaxation via Ca2+ -activated K+ channels.
This article is protected by copyright. All rights reserved. PMID: 31444788 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 24, 2019 Category: Drugs & Pharmacology Authors: Kim HJ, Yin MZ, Cho S, Kim SE, Choi SW, Ye SK, Yoo HY, Kim SJ Tags: Clin Exp Pharmacol Physiol Source Type: research

Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain.
This article is protected by copyright. All rights reserved. PMID: 31429474 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Shenoy PA, Kuo A, Leparc G, Hildebrandt T, Rust W, Nicholson JR, Corradini L, Vetter I, Smith MT Tags: Clin Exp Pharmacol Physiol Source Type: research

Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3 β/β-catenin signaling.
This article is protected by copyright. All rights reserved. PMID: 31429477 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Wang H, Sun L, Jiang J, Yu S, Zhou Q Tags: Clin Exp Pharmacol Physiol Source Type: research

Galanin receptors activation modulates myocardial metabolic and antioxidant responses to ischaemia/reperfusion stress.
This article is protected by copyright. All rights reserved. PMID: 31429479 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Studneva I, Serebryakova L, Veselova O, Pal'keeva M, Molokoedov A, Ovchinnikov M, Konovalova G, Lankin V, Sidorova M, Pisarenko O Tags: Clin Exp Pharmacol Physiol Source Type: research

Propofol inhibits biological functions of leukemia stem and differentiated cells through suppressing Wnt/ β-catenin and Akt/mTOR.
This article is protected by copyright. All rights reserved. PMID: 31429973 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Chen L, Wan Y, Liu Y, Li T Tags: Clin Exp Pharmacol Physiol Source Type: research

Alpha-Tocopherol during lactation and after weaning alters the programming effect of prenatal high salt intake on cardiac and renal functions of adult male offspring.
In conclusion, the combination of maternal saline overload and high α-Tocopherol immediately after birth leads to simultaneous cardiovascular and renal alterations in the young offspring, like those encountered in type V cardiorenal syndrome. This article is protected by copyright. All rights reserved. PMID: 31410879 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 14, 2019 Category: Drugs & Pharmacology Authors: Cabral EV, Vieira LD, Sant'Helena BRM, Ribeiro VS, Farias JS, Aires RS, Paz ST, Muzi-Filho H, Paixão AD, Vieyra A Tags: Clin Exp Pharmacol Physiol Source Type: research

Hypoxia-inducible factor 1 alpha and nuclear related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD. PMID: 31408200 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 13, 2019 Category: Drugs & Pharmacology Authors: Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM Tags: Clin Exp Pharmacol Physiol Source Type: research

MiR-203a-3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen-induced retinopathy (OIR) rat model via targeting VEGFA and HIF-1 α.
In conclusion, our findings demonstrate that up-regulation of miR-203a-3p might inhibit pathological retinal angiogenesis of PDR by targeting VEGFA and HIF-1α. PMID: 31408201 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 13, 2019 Category: Drugs & Pharmacology Authors: Han N, Xu H, Yu N, Wu Y, Yu L Tags: Clin Exp Pharmacol Physiol Source Type: research

Morin attenuates oxidized low-density lipoprotein-mediated injury by inducing autophagy via activating AMPK signaling in HUVECs.
Abstract Endothelial dysfunction is a precursor of cardiovascular disease, and oxidized low-density lipoprotein (ox-LDL) has been implicated in the development of atherosclerosis by directly targeting endothelial cells. Morin, a natural flavonol, has been shown to protect endothelial cells from dysfunction. The present study was designed to evaluate the effect of morin on ox-LDL-induced injury and to investigated the underlying molecular mechanisms in human umbilical vein endothelial cells (HUVECs). The results showed that morin alleviated ox-LDL-induced endothelial injury and promoted the viability of HUVECs expo...
Source: Clinical and Experimental Pharmacology and Physiology - August 12, 2019 Category: Drugs & Pharmacology Authors: Zhang X, Han X, Zhang P, Zhou T, Chen Y, Jian J, Ma X Tags: Clin Exp Pharmacol Physiol Source Type: research

Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis.
This article is protected by copyright. All rights reserved. PMID: 31396972 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Mohammadalipour A, Hashemnia M, Goudarzi F, Pouyandeh Ravan A Tags: Clin Exp Pharmacol Physiol Source Type: research

Insulin-like growth factor-binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
In conclusion, our study demonstrates that IGFBP7 contributes to hepatic steatosis and insulin resistance in NAFLD development, which might serve as a novel therapeutic agent for the treatment of NAFLD. This article is protected by copyright. All rights reserved. PMID: 31397492 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Yan H, Li T, Wang Y, Li H, Xu J, Lu X Tags: Clin Exp Pharmacol Physiol Source Type: research

Chronic consumption of a high-fat diet rich in corn oil activates intrinsic cell death pathway and induces several ultrastructural changes in the atria of healthy and type 1 diabetic rat.
In conclusion, chronic consumption of CO-HFD by T1DM-induced rats elicits significant biochemical and ultrastructural damage to rat atrial cells accompanied by elevated oxidative stress and mitochondria-mediated cell death. This article is protected by copyright. All rights reserved. PMID: 31398260 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Eid RA, Eleawa SM, Alkhateeb MA, Aldera H, Zaki MSA, Al-Shraim M, Saeed MA, El-Kott AF, Alaa Eldeen M, Alassiri M, Alshehri MM, Salem Al-Shudiefat AA, Khalil MA Tags: Clin Exp Pharmacol Physiol Source Type: research

The protective effects of L-carnitine on myocardial ischemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF- κB pathway and the activation of Nrf2 pathway.
This article is protected by copyright. All rights reserved. PMID: 31393619 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 8, 2019 Category: Drugs & Pharmacology Authors: Li M, Xu S, Geng Y, Sun L, Wang R, Yan Y, Wang H, Li Y, Yi Q, Zhang Y, Hao J, Deng C, Li W, Xue L Tags: Clin Exp Pharmacol Physiol Source Type: research

Isoliquiritigenin-induced vasodilation by Activating large-conductance Ca2+ -activated K+ channels In mouse mesenteric arteries.
This article is protected by copyright. All rights reserved. PMID: 31394004 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 8, 2019 Category: Drugs & Pharmacology Authors: Ye Y, Gao M, Feng L, Feng B, Ma X Tags: Clin Exp Pharmacol Physiol Source Type: research

Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats.
This article is protected by copyright. All rights reserved. PMID: 31380572 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Tadaki H, Sasase T, Fukuda S, Toriniwa Y, Harada K, Ohta T, Yamada T Tags: Clin Exp Pharmacol Physiol Source Type: research

MicroRNA-198-5p inhibits the migration and invasion of non-small lung cancer cells by targeting fucosyltransferase 8.
This article is protected by copyright. All rights reserved. PMID: 31381176 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Wang S, Zhang X, Yang C, Xu S Tags: Clin Exp Pharmacol Physiol Source Type: research

Analyzing the percentage of different PD-1+ T cell subsets in peripheral blood and bronchoalveolar lavage fluid of small cell lung cancer patients: A prospective study.
This article is protected by copyright. All rights reserved. PMID: 31381177 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Hu X, Gu Y, Li D, Zhao S, Hua S, Jiang Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Corrigendum.
Authors: PMID: 31332827 [PubMed - in process] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 25, 2019 Category: Drugs & Pharmacology Tags: Clin Exp Pharmacol Physiol Source Type: research

Glutathione peroxidase-1 gene rescues cocaine-induced conditioned place preference in mice by inhibiting σ-1 receptor expression.
This article is protected by copyright. All rights reserved. PMID: 31332816 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 23, 2019 Category: Drugs & Pharmacology Authors: Pham DT, Chung YH, Mai HN, Sharma N, Yun J, Kim HJ, Cheong JH, Jeong JH, Kim DJ, Shin EJ, Kim HC Tags: Clin Exp Pharmacol Physiol Source Type: research

Protective effects of G αq-RGS2 signaling inhibitor in aminophylline induced cardiac arrhythmia.
This article is protected by copyright. All rights reserved. PMID: 31330058 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Beladiya JV, Chaudagar KK, Mehta AA Tags: Clin Exp Pharmacol Physiol Source Type: research

MiR-21-3p modulates lipopolysaccharide-induced inflammation and apoptosis via targeting TGS4 in retinal pigment epithelial cells.
This article is protected by copyright. All rights reserved. PMID: 31330059 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Liu J, Ma Z, Ran Z Tags: Clin Exp Pharmacol Physiol Source Type: research

The anticholinergic drug oxybutynin inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 0.38 μM and a Hill coefficient (n) of 2.25 0.12. Application of oxybutynin shifted the activation curve to the right and the inactivation curve to the left. Pretreatment with the Kv1.5 subtype inhibitor DPO-1 and the Kv2.1 subtype inhibitor guangxitoxin suppressed the oxybutynin-induced inhibition of the Kv current. However, application of the Kv7 su...
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Li H, Seo MS, An JR, Jung HS, Ha KS, Han ET, Hong SH, Min Bae Y, Ryu DR, Park WS Tags: Clin Exp Pharmacol Physiol Source Type: research

Current status and future directions in the treatment of bone metastases from breast cancer.
This article is protected by copyright. All rights reserved. PMID: 31330061 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Leto G Tags: Clin Exp Pharmacol Physiol Source Type: research

Potential Roles of Chromium on Inflammatory Biomarkers in Diabetes: A Systematic Review.
This article is protected by copyright. All rights reserved. PMID: 31330062 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Moradi F, Maleki V, Saleh-Ghadimi S, Kooshki F, Pourghassem Gargari B Tags: Clin Exp Pharmacol Physiol Source Type: research

Th17 cells in glaucoma patients promote Ig production in IL-17A and IL-21-dependent manner.
This article is protected by copyright. All rights reserved. PMID: 31330064 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Ren Y, Qi Y, Su X Tags: Clin Exp Pharmacol Physiol Source Type: research

Effects of 7,8-Dihydroxyflavone on Rat Jejunal Dynamics Subjected to Ischemia-Reperfusion Injury.
This article is protected by copyright. All rights reserved. PMID: 31313342 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 17, 2019 Category: Drugs & Pharmacology Authors: Ma L, Qu Z, Luan X, Jiang X, Pan R, Zhao T, Ma X, He B Tags: Clin Exp Pharmacol Physiol Source Type: research

Hypoxic Pulmonary Vasoconstriction Is Lacking In Rats With Type 1 Diabetes.
This article is protected by copyright. All rights reserved. PMID: 31314914 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 17, 2019 Category: Drugs & Pharmacology Authors: Soloviev A, Ivanova I, Melnyk M, Dobrelia N, Khromov A Tags: Clin Exp Pharmacol Physiol Source Type: research

Heat-killed Salmonella Typhimurium mitigated Radiation-induced Lung Injury.
In conclusion, our data showed that HKST effectively mitigated RILI through regulating TGF-β, provide novel treatment strategy for RILI in whole body irradiation and radiotherapy. This article is protected by copyright. All rights reserved. PMID: 31291700 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 10, 2019 Category: Drugs & Pharmacology Authors: Kun C, Tao L, Leiyuan H, Yunhao F, Wu N, Zhe L, Yuanyuan C, Xiao L, Hongran Q, Jianming C, Fu G, Yanyong Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Biophysical and Biological Characterization of PEGylated Recombinant Human Endostatin (M2 ES).
This article is protected by copyright. All rights reserved. PMID: 31278773 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 6, 2019 Category: Drugs & Pharmacology Authors: Guo L, Xu B, Zhou D, Chang G, Fu Y, Liu L, Luo Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Calcosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis. This article is protected by copyright. All rights reserved. PMID: 31276230 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 5, 2019 Category: Drugs & Pharmacology Authors: El-Kott AF, Al-Kahtani MA, Shati AA Tags: Clin Exp Pharmacol Physiol Source Type: research

Metformin inhibits high glucose-induced mesangial cell proliferation, inflammation and ECM expression through the SIRT1-FOXO1-autophagy axis.
Abstract The aim of this study was to investigate the role of metformin in high glucose-induced mesangial cell proliferation, inflammation and extracellular matrix (ECM) accumulation and to elucidate the underlying mechanism of metformin function. An MTT assay was used to examine rat mesangial cell (RMC) proliferation. The levels of TNF-α, IL-6 and TGF-β in RMCs were determined by ELISA. The protein expression of fibronectin, collagen IV and autophagy-related proteins (Beclin-1, LC3-I and LC3-II) in RMCs was detected using western blot. Fluorescence microscopy analysis was carried out to evaluate RMC au...
Source: Clinical and Experimental Pharmacology and Physiology - July 2, 2019 Category: Drugs & Pharmacology Authors: Xu J, Chen Y, Xing Y, Ye S Tags: Clin Exp Pharmacol Physiol Source Type: research

Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
eong JH Abstract The role as well as the molecular mechanisms of protectin DX (PDX) in the prevention of hepatic insulin resistance, a hallmark of type 2 diabetes, remains unknown. Therefore, the present study was designed to explore the direct impact of PDX on insulin resistance and to investigate the expression of fetuin-A and selenoprotein P (SeP), hepatokines that are involved in insulin signalling, in hepatocytes. Human serum levels of PDX as well as fetuin-A and SeP were determined by high-performance liquid chromatography (HPLC). Human primary hepatocytes were treated with palmitate and PDX. NF-κB pho...
Source: Clinical and Experimental Pharmacology and Physiology - June 27, 2019 Category: Drugs & Pharmacology Authors: Jung TW, Ahn SH, Shin JW, Kim HC, Park ES, Abd El-Aty AM, Hacımüftüoğlu A, Song KH, Jeong JH Tags: Clin Exp Pharmacol Physiol Source Type: research

MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2.
Abstract Colorectal cancer (CRC) is one of the most common malignancies with high levels of invasiveness, drug resistance and mortality, but the internal mechanisms of CRC are largely unknown. MicroRNAs (miRs) have been reported to be involved in the development of CRC, and numerous studied have demonstrated that the abnormal expression of miR-33a-5p might be associated with CRC. However, the function and downstream mechanism of miR-33a-5p in colorectal cancer (CRC) is remain unclear. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, was interestingly con...
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Yan Y, Zhang D, Lei T, Zhao C, Han J, Cui J, Wang Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Inhibition of mitochondrial respiration by tigecycline selectively targets thyroid carcinoma and increases chemosensitivity.
This article is protected by copyright. All rights reserved. PMID: 31209921 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Wang Y, Xie F, Chen D, Wang L Tags: Clin Exp Pharmacol Physiol Source Type: research

T-bet interferes with PD-1/PD-L1-mediated suppression of CD4+ T cell inflammation and survival in Crohn's disease.
This article is protected by copyright. All rights reserved. PMID: 31210370 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Ma F, Zhao M, Song Z, Wang Z Tags: Clin Exp Pharmacol Physiol Source Type: research

Esculetin inhibits histamine-induced the expression of inflammatory cytokines and mucin in nasal epithelial cells.
This article is protected by copyright. All rights reserved. PMID: 31211861 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Sun B, Wang B, Xu M Tags: Clin Exp Pharmacol Physiol Source Type: research

Influence of renal ischemia-reperfusion injury on renal neutrophil gelatinase- associated lipocalin receptor (24p3R) in rats.
This study was undertaken to evaluate an influence of renal ischemia-reperfusion injury on 24p3R. Unilateral renal pedicle was clamped for 0, 10, 20, 30, or 45 min in male Wistar rats. Urine was collected for 24 hours after reperfusion, and ischemic kidney and blood sample were obtained. Apparent histological injury in the ischemic kidney was detected in the 30min- and 45 min-treated groups. Urinary NGAL excretion elevated in rats with renal ischemia for more than 20 min, while serum creatinine increased in rats for more than 30 min of ischemia. Renal protein expression of NGAL did not significantly change. Renal mRNA expr...
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A Tags: Clin Exp Pharmacol Physiol Source Type: research

SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway.
In conclusion, our results demonstrated that SPNS2 promoted proliferation, migration and invasion, and inhibited apoptosis by regulating S1P/S1PR1/3 axis and activating Akt and ERK pathway in CRC cells. This article is protected by copyright. All rights reserved. PMID: 31206801 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 17, 2019 Category: Drugs & Pharmacology Authors: Gu X, Jiang Y, Xue W, Song C, Wang Y, Liu Y, Cui B Tags: Clin Exp Pharmacol Physiol Source Type: research

MLK3 silence induces cervical cancer cell apoptosis via the Notch-1/autophagy network.
This article is protected by copyright. All rights reserved. PMID: 31192472 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 13, 2019 Category: Drugs & Pharmacology Authors: Ma L, Cheng Y, Zeng J Tags: Clin Exp Pharmacol Physiol Source Type: research

Time evolution of methotrexate-induced kidney injury. A comparative study between different biomarkers of renal damage in rats.
This article is protected by copyright. All rights reserved. PMID: 31187885 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 12, 2019 Category: Drugs & Pharmacology Authors: Severin MJ, Campagno RV, Brandoni A, Torres AM Tags: Clin Exp Pharmacol Physiol Source Type: research

Adaptation of glycocalyx, nitric oxide synthase expression and vascular cell apoptosis in conduit arteries of tail-suspended rats.
This article is protected by copyright. All rights reserved. PMID: 31175664 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 7, 2019 Category: Drugs & Pharmacology Authors: Kang H, Wu C, Qu Y, Gao M, Zhang W, Sun A, Deng X Tags: Clin Exp Pharmacol Physiol Source Type: research