Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTThe contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated the effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin diabetic rats (DM). In Sprague Dawley DM and NG rats, 3 weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next 2 weeks using subcutaneously implanted osmotic minip...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Clin Exp Pharmacol Physiol. 2021 Dec 6. doi: 10.1111/1440-1681.13618. Online ahead of print.ABSTRACTContribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabetes. We investigated effects of Ang1-7 supplementation on blood pressure, renal circulation and intrarenal reactivity (IVR) to vasoactive agents in normoglycaemic (NG) and streptozotocin-diabetic rats (DM). In Sprague Dawley DM and NG rats, three weeks after streptozotocin (60 mg/kg i.p.) or solvent injection, Ang1-7 was administered (400 ng/min) over the next two weeks using subcutaneously implanted osmotic minipum...
Source: Clinical and Experimental Pharmacology and Physiology - December 6, 2021 Category: Drugs & Pharmacology Authors: Marta Kuczeriszka Leszek Dobrowolski Agnieszka Walkowska Iwona Baranowska Joanna D Sitek El żbieta Kompanowska-Jezierska Source Type: research

Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative
Clin Exp Pharmacol Physiol. 2021 Dec 4. doi: 10.1111/1440-1681.13617. Online ahead of print.ABSTRACTPain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, are known for their wide range of adverse effects, making it important to develop new drugs. Thus, this study aimed to analyze the action of the hybrid compound cis- (±) -acetate of 4-chloro-6- (naphthalene-1-yl) -tetrahydro-2h-pyran -2-yl) methyl2- (2- (2,6-dichlorophenylamine) phenyl (LS19) under acute nociceptive conditi...
Source: Clinical and Experimental Pharmacology and Physiology - December 4, 2021 Category: Drugs & Pharmacology Authors: Gabriela Mastrangelo Gon çalves Joyce Mattos de Oliveira Thayane Ferreira da Costa Fernandes Gabriela de Carvalho Cid Roberto Laureano-Melo Wellington da Silva C ôrtes Vivian de Assun ção Nogueira Carvalho Saulo Luis Capim M ário Luiz Araujo de Almei Source Type: research

Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative
Clin Exp Pharmacol Physiol. 2021 Dec 4. doi: 10.1111/1440-1681.13617. Online ahead of print.ABSTRACTPain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, are known for their wide range of adverse effects, making it important to develop new drugs. Thus, this study aimed to analyze the action of the hybrid compound cis- (±) -acetate of 4-chloro-6- (naphthalene-1-yl) -tetrahydro-2h-pyran -2-yl) methyl2- (2- (2,6-dichlorophenylamine) phenyl (LS19) under acute nociceptive conditi...
Source: Clinical and Experimental Pharmacology and Physiology - December 4, 2021 Category: Drugs & Pharmacology Authors: Gabriela Mastrangelo Gon çalves Joyce Mattos de Oliveira Thayane Ferreira da Costa Fernandes Gabriela de Carvalho Cid Roberto Laureano-Melo Wellington da Silva C ôrtes Vivian de Assun ção Nogueira Carvalho Saulo Luis Capim M ário Luiz Araujo de Almei Source Type: research

Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative
Clin Exp Pharmacol Physiol. 2021 Dec 4. doi: 10.1111/1440-1681.13617. Online ahead of print.ABSTRACTPain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, are known for their wide range of adverse effects, making it important to develop new drugs. Thus, this study aimed to analyze the action of the hybrid compound cis- (±) -acetate of 4-chloro-6- (naphthalene-1-yl) -tetrahydro-2h-pyran -2-yl) methyl2- (2- (2,6-dichlorophenylamine) phenyl (LS19) under acute nociceptive conditi...
Source: Clinical and Experimental Pharmacology and Physiology - December 4, 2021 Category: Drugs & Pharmacology Authors: Gabriela Mastrangelo Gon çalves Joyce Mattos de Oliveira Thayane Ferreira da Costa Fernandes Gabriela de Carvalho Cid Roberto Laureano-Melo Wellington da Silva C ôrtes Vivian de Assun ção Nogueira Carvalho Saulo Luis Capim M ário Luiz Araujo de Almei Source Type: research

Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats
Clin Exp Pharmacol Physiol. 2021 Dec 1. doi: 10.1111/1440-1681.13616. Online ahead of print.ABSTRACTThe present study aims to evaluate the combined effect of ischemic-postconditioning (IPostC) and nicotinamide mononucleotide (NMN) on cardioprotection and mitochondrial function in aged rats subjected to myocardial ischemia-reperfusion (IR) injury. Sixty aged Wistar rats were randomly divided into 5 groups (n=12), including sham, control, NMN, IPostC, and NMN+IPostC. Regional ischemia was induced by 30-min occlusion of the left anterior descending coronary artery (LAD) followed by 60-min reperfusion. IPostC was applied at th...
Source: Clinical and Experimental Pharmacology and Physiology - December 2, 2021 Category: Drugs & Pharmacology Authors: Mojgan Rajabi Manouchehr S Vafaee Leila Hosseini Reza Badalzadeh Source Type: research

Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats
Clin Exp Pharmacol Physiol. 2021 Dec 1. doi: 10.1111/1440-1681.13616. Online ahead of print.ABSTRACTThe present study aims to evaluate the combined effect of ischemic-postconditioning (IPostC) and nicotinamide mononucleotide (NMN) on cardioprotection and mitochondrial function in aged rats subjected to myocardial ischemia-reperfusion (IR) injury. Sixty aged Wistar rats were randomly divided into 5 groups (n=12), including sham, control, NMN, IPostC, and NMN+IPostC. Regional ischemia was induced by 30-min occlusion of the left anterior descending coronary artery (LAD) followed by 60-min reperfusion. IPostC was applied at th...
Source: Clinical and Experimental Pharmacology and Physiology - December 2, 2021 Category: Drugs & Pharmacology Authors: Mojgan Rajabi Manouchehr S Vafaee Leila Hosseini Reza Badalzadeh Source Type: research

Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The anti-arrhythmic drug, amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups (1) Control, (2) Control-lithium and (3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone, (4) Epilepsy model, induced by sequ...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The anti-arrhythmic drug, amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups (1) Control, (2) Control-lithium and (3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone, (4) Epilepsy model, induced by sequ...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Cardioprotective effects of Amiodarone in a rat model of epilepsy-induced cardiac dysfunction
Clin Exp Pharmacol Physiol. 2021 Nov 19. doi: 10.1111/1440-1681.13615. Online ahead of print.ABSTRACTCardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is under investigation for its therapeutic effects in epilepsy. We aimed to evaluate the possible effects of amiodarone on cardiac injury during status epilepticus, as it can cause prolongation of the QT interval. Five rat groups were enrolled in the study; three control groups 1) Control, 2) Control-lithium and 3) Control-Amio, treated with 150 mg/kg/intraperitoneal amiodarone. 4) Epilepsy model, induced by sequential...
Source: Clinical and Experimental Pharmacology and Physiology - November 19, 2021 Category: Drugs & Pharmacology Authors: Inas A Harb Hend Ashour Abeer Mostafa Hala M El Hanbuli Eman Hassan Nadwa Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research

Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13613. Online ahead of print.ABSTRACTDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumor growth and progression. Moreover, using both in vit...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Zhao-Peng Yao Hui Zhu Feng Shen Dan Gong Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research

Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13613. Online ahead of print.ABSTRACTDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumor growth and progression. Moreover, using both in vit...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Zhao-Peng Yao Hui Zhu Feng Shen Dan Gong Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research

Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13613. Online ahead of print.ABSTRACTDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumor growth and progression. Moreover, using both in vit...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Zhao-Peng Yao Hui Zhu Feng Shen Dan Gong Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research

Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13613. Online ahead of print.ABSTRACTDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumor growth and progression. Moreover, using both in vit...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Zhao-Peng Yao Hui Zhu Feng Shen Dan Gong Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research

Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13613. Online ahead of print.ABSTRACTDespite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in children and is associated with poor prognosis. Growing evidence has supported dysregulation of threonine and tyrosine protein kinase (TTK) expression as a hallmark of multiple cancers, however, its function in osteosarcoma remains to be elucidated. In the present study, we found that TTK was frequently overexpressed in osteosarcoma and associated with increased tumor growth and progression. Moreover, using both in vit...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Zhao-Peng Yao Hui Zhu Feng Shen Dan Gong Source Type: research

Thymoquinone Attenuates Isoproterenol-Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase-9 Expression
Clin Exp Pharmacol Physiol. 2021 Nov 12. doi: 10.1111/1440-1681.13614. Online ahead of print.ABSTRACTThymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the effect of TQ on apoptotic parameters and MMP-9 expression in isoproterenol (ISP)-induced myocardial infarction (MI). TQ was given once daily for 7 days at doses of 10 and 20 mg/kg orally with ISP (86 mg/kg; s.c.) administered on the 6th and 7th days. TQ pretreatment protected against ISP-induced MI as approved by normalization of electrocardiogram (ECG) and b (CK)-MB, minimal histopathological changes, and reductio...
Source: Clinical and Experimental Pharmacology and Physiology - November 12, 2021 Category: Drugs & Pharmacology Authors: Marwa Medhet Wesam M El-Bakly Amira M Badr Azza Awad Ebtehal El-Demerdash Source Type: research