Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain.
This article is protected by copyright. All rights reserved. PMID: 31429474 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Shenoy PA, Kuo A, Leparc G, Hildebrandt T, Rust W, Nicholson JR, Corradini L, Vetter I, Smith MT Tags: Clin Exp Pharmacol Physiol Source Type: research

Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3 β/β-catenin signaling.
This article is protected by copyright. All rights reserved. PMID: 31429477 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Wang H, Sun L, Jiang J, Yu S, Zhou Q Tags: Clin Exp Pharmacol Physiol Source Type: research

Galanin receptors activation modulates myocardial metabolic and antioxidant responses to ischaemia/reperfusion stress.
This article is protected by copyright. All rights reserved. PMID: 31429479 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Studneva I, Serebryakova L, Veselova O, Pal'keeva M, Molokoedov A, Ovchinnikov M, Konovalova G, Lankin V, Sidorova M, Pisarenko O Tags: Clin Exp Pharmacol Physiol Source Type: research

Propofol inhibits biological functions of leukemia stem and differentiated cells through suppressing Wnt/ β-catenin and Akt/mTOR.
This article is protected by copyright. All rights reserved. PMID: 31429973 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 20, 2019 Category: Drugs & Pharmacology Authors: Chen L, Wan Y, Liu Y, Li T Tags: Clin Exp Pharmacol Physiol Source Type: research

Alpha-Tocopherol during lactation and after weaning alters the programming effect of prenatal high salt intake on cardiac and renal functions of adult male offspring.
In conclusion, the combination of maternal saline overload and high α-Tocopherol immediately after birth leads to simultaneous cardiovascular and renal alterations in the young offspring, like those encountered in type V cardiorenal syndrome. This article is protected by copyright. All rights reserved. PMID: 31410879 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 14, 2019 Category: Drugs & Pharmacology Authors: Cabral EV, Vieira LD, Sant'Helena BRM, Ribeiro VS, Farias JS, Aires RS, Paz ST, Muzi-Filho H, Paixão AD, Vieyra A Tags: Clin Exp Pharmacol Physiol Source Type: research

Hypoxia-inducible factor 1 alpha and nuclear related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.
In conclusion, the present study suggests that ABZ exerts a neuroprotective effect in a rotenone-induced PD model associated with HIF-1α and Nurr1 activation and thus may be a viable candidate for treating PD. PMID: 31408200 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 13, 2019 Category: Drugs & Pharmacology Authors: Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM Tags: Clin Exp Pharmacol Physiol Source Type: research

MiR-203a-3p inhibits retinal angiogenesis and alleviates proliferative diabetic retinopathy in oxygen-induced retinopathy (OIR) rat model via targeting VEGFA and HIF-1 α.
In conclusion, our findings demonstrate that up-regulation of miR-203a-3p might inhibit pathological retinal angiogenesis of PDR by targeting VEGFA and HIF-1α. PMID: 31408201 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 13, 2019 Category: Drugs & Pharmacology Authors: Han N, Xu H, Yu N, Wu Y, Yu L Tags: Clin Exp Pharmacol Physiol Source Type: research

Morin attenuates oxidized low-density lipoprotein-mediated injury by inducing autophagy via activating AMPK signaling in HUVECs.
Abstract Endothelial dysfunction is a precursor of cardiovascular disease, and oxidized low-density lipoprotein (ox-LDL) has been implicated in the development of atherosclerosis by directly targeting endothelial cells. Morin, a natural flavonol, has been shown to protect endothelial cells from dysfunction. The present study was designed to evaluate the effect of morin on ox-LDL-induced injury and to investigated the underlying molecular mechanisms in human umbilical vein endothelial cells (HUVECs). The results showed that morin alleviated ox-LDL-induced endothelial injury and promoted the viability of HUVECs expo...
Source: Clinical and Experimental Pharmacology and Physiology - August 12, 2019 Category: Drugs & Pharmacology Authors: Zhang X, Han X, Zhang P, Zhou T, Chen Y, Jian J, Ma X Tags: Clin Exp Pharmacol Physiol Source Type: research

Increasing the effectiveness of tyrosine kinase inhibitor (TKI) in combination with a statin in reducing liver fibrosis.
This article is protected by copyright. All rights reserved. PMID: 31396972 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Mohammadalipour A, Hashemnia M, Goudarzi F, Pouyandeh Ravan A Tags: Clin Exp Pharmacol Physiol Source Type: research

Insulin-like growth factor-binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease.
In conclusion, our study demonstrates that IGFBP7 contributes to hepatic steatosis and insulin resistance in NAFLD development, which might serve as a novel therapeutic agent for the treatment of NAFLD. This article is protected by copyright. All rights reserved. PMID: 31397492 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Yan H, Li T, Wang Y, Li H, Xu J, Lu X Tags: Clin Exp Pharmacol Physiol Source Type: research

Chronic consumption of a high-fat diet rich in corn oil activates intrinsic cell death pathway and induces several ultrastructural changes in the atria of healthy and type 1 diabetic rat.
In conclusion, chronic consumption of CO-HFD by T1DM-induced rats elicits significant biochemical and ultrastructural damage to rat atrial cells accompanied by elevated oxidative stress and mitochondria-mediated cell death. This article is protected by copyright. All rights reserved. PMID: 31398260 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 9, 2019 Category: Drugs & Pharmacology Authors: Eid RA, Eleawa SM, Alkhateeb MA, Aldera H, Zaki MSA, Al-Shraim M, Saeed MA, El-Kott AF, Alaa Eldeen M, Alassiri M, Alshehri MM, Salem Al-Shudiefat AA, Khalil MA Tags: Clin Exp Pharmacol Physiol Source Type: research

The protective effects of L-carnitine on myocardial ischemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF- κB pathway and the activation of Nrf2 pathway.
This article is protected by copyright. All rights reserved. PMID: 31393619 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 8, 2019 Category: Drugs & Pharmacology Authors: Li M, Xu S, Geng Y, Sun L, Wang R, Yan Y, Wang H, Li Y, Yi Q, Zhang Y, Hao J, Deng C, Li W, Xue L Tags: Clin Exp Pharmacol Physiol Source Type: research

Isoliquiritigenin-induced vasodilation by Activating large-conductance Ca2+ -activated K+ channels In mouse mesenteric arteries.
This article is protected by copyright. All rights reserved. PMID: 31394004 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 8, 2019 Category: Drugs & Pharmacology Authors: Ye Y, Gao M, Feng L, Feng B, Ma X Tags: Clin Exp Pharmacol Physiol Source Type: research

Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats.
This article is protected by copyright. All rights reserved. PMID: 31380572 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Tadaki H, Sasase T, Fukuda S, Toriniwa Y, Harada K, Ohta T, Yamada T Tags: Clin Exp Pharmacol Physiol Source Type: research

MicroRNA-198-5p inhibits the migration and invasion of non-small lung cancer cells by targeting fucosyltransferase 8.
This article is protected by copyright. All rights reserved. PMID: 31381176 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Wang S, Zhang X, Yang C, Xu S Tags: Clin Exp Pharmacol Physiol Source Type: research

Analyzing the percentage of different PD-1+ T cell subsets in peripheral blood and bronchoalveolar lavage fluid of small cell lung cancer patients: A prospective study.
This article is protected by copyright. All rights reserved. PMID: 31381177 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - August 5, 2019 Category: Drugs & Pharmacology Authors: Hu X, Gu Y, Li D, Zhao S, Hua S, Jiang Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Corrigendum.
Authors: PMID: 31332827 [PubMed - in process] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 25, 2019 Category: Drugs & Pharmacology Tags: Clin Exp Pharmacol Physiol Source Type: research

Glutathione peroxidase-1 gene rescues cocaine-induced conditioned place preference in mice by inhibiting σ-1 receptor expression.
This article is protected by copyright. All rights reserved. PMID: 31332816 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 23, 2019 Category: Drugs & Pharmacology Authors: Pham DT, Chung YH, Mai HN, Sharma N, Yun J, Kim HJ, Cheong JH, Jeong JH, Kim DJ, Shin EJ, Kim HC Tags: Clin Exp Pharmacol Physiol Source Type: research

Protective effects of G αq-RGS2 signaling inhibitor in aminophylline induced cardiac arrhythmia.
This article is protected by copyright. All rights reserved. PMID: 31330058 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Beladiya JV, Chaudagar KK, Mehta AA Tags: Clin Exp Pharmacol Physiol Source Type: research

MiR-21-3p modulates lipopolysaccharide-induced inflammation and apoptosis via targeting TGS4 in retinal pigment epithelial cells.
This article is protected by copyright. All rights reserved. PMID: 31330059 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Liu J, Ma Z, Ran Z Tags: Clin Exp Pharmacol Physiol Source Type: research

The anticholinergic drug oxybutynin inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 0.38 μM and a Hill coefficient (n) of 2.25 0.12. Application of oxybutynin shifted the activation curve to the right and the inactivation curve to the left. Pretreatment with the Kv1.5 subtype inhibitor DPO-1 and the Kv2.1 subtype inhibitor guangxitoxin suppressed the oxybutynin-induced inhibition of the Kv current. However, application of the Kv7 su...
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Li H, Seo MS, An JR, Jung HS, Ha KS, Han ET, Hong SH, Min Bae Y, Ryu DR, Park WS Tags: Clin Exp Pharmacol Physiol Source Type: research

Current status and future directions in the treatment of bone metastases from breast cancer.
This article is protected by copyright. All rights reserved. PMID: 31330061 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Leto G Tags: Clin Exp Pharmacol Physiol Source Type: research

Potential Roles of Chromium on Inflammatory Biomarkers in Diabetes: A Systematic Review.
This article is protected by copyright. All rights reserved. PMID: 31330062 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Moradi F, Maleki V, Saleh-Ghadimi S, Kooshki F, Pourghassem Gargari B Tags: Clin Exp Pharmacol Physiol Source Type: research

Th17 cells in glaucoma patients promote Ig production in IL-17A and IL-21-dependent manner.
This article is protected by copyright. All rights reserved. PMID: 31330064 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 22, 2019 Category: Drugs & Pharmacology Authors: Ren Y, Qi Y, Su X Tags: Clin Exp Pharmacol Physiol Source Type: research

Effects of 7,8-Dihydroxyflavone on Rat Jejunal Dynamics Subjected to Ischemia-Reperfusion Injury.
This article is protected by copyright. All rights reserved. PMID: 31313342 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 17, 2019 Category: Drugs & Pharmacology Authors: Ma L, Qu Z, Luan X, Jiang X, Pan R, Zhao T, Ma X, He B Tags: Clin Exp Pharmacol Physiol Source Type: research

Hypoxic Pulmonary Vasoconstriction Is Lacking In Rats With Type 1 Diabetes.
This article is protected by copyright. All rights reserved. PMID: 31314914 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 17, 2019 Category: Drugs & Pharmacology Authors: Soloviev A, Ivanova I, Melnyk M, Dobrelia N, Khromov A Tags: Clin Exp Pharmacol Physiol Source Type: research

Heat-killed Salmonella Typhimurium mitigated Radiation-induced Lung Injury.
In conclusion, our data showed that HKST effectively mitigated RILI through regulating TGF-β, provide novel treatment strategy for RILI in whole body irradiation and radiotherapy. This article is protected by copyright. All rights reserved. PMID: 31291700 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 10, 2019 Category: Drugs & Pharmacology Authors: Kun C, Tao L, Leiyuan H, Yunhao F, Wu N, Zhe L, Yuanyuan C, Xiao L, Hongran Q, Jianming C, Fu G, Yanyong Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Biophysical and Biological Characterization of PEGylated Recombinant Human Endostatin (M2 ES).
This article is protected by copyright. All rights reserved. PMID: 31278773 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 6, 2019 Category: Drugs & Pharmacology Authors: Guo L, Xu B, Zhou D, Chang G, Fu Y, Liu L, Luo Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Calcosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.
Conclusion, Calycosin stimulates CRC cell apoptosis and inhibits their invasion by acting as SIRT1 activator which induces activation of AMPK-induced inhibition of Akt/mTOR axis. This article is protected by copyright. All rights reserved. PMID: 31276230 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - July 5, 2019 Category: Drugs & Pharmacology Authors: El-Kott AF, Al-Kahtani MA, Shati AA Tags: Clin Exp Pharmacol Physiol Source Type: research

Metformin inhibits high glucose-induced mesangial cell proliferation, inflammation and ECM expression through the SIRT1-FOXO1-autophagy axis.
Abstract The aim of this study was to investigate the role of metformin in high glucose-induced mesangial cell proliferation, inflammation and extracellular matrix (ECM) accumulation and to elucidate the underlying mechanism of metformin function. An MTT assay was used to examine rat mesangial cell (RMC) proliferation. The levels of TNF-α, IL-6 and TGF-β in RMCs were determined by ELISA. The protein expression of fibronectin, collagen IV and autophagy-related proteins (Beclin-1, LC3-I and LC3-II) in RMCs was detected using western blot. Fluorescence microscopy analysis was carried out to evaluate RMC au...
Source: Clinical and Experimental Pharmacology and Physiology - July 2, 2019 Category: Drugs & Pharmacology Authors: Xu J, Chen Y, Xing Y, Ye S Tags: Clin Exp Pharmacol Physiol Source Type: research

Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
eong JH Abstract The role as well as the molecular mechanisms of protectin DX (PDX) in the prevention of hepatic insulin resistance, a hallmark of type 2 diabetes, remains unknown. Therefore, the present study was designed to explore the direct impact of PDX on insulin resistance and to investigate the expression of fetuin-A and selenoprotein P (SeP), hepatokines that are involved in insulin signalling, in hepatocytes. Human serum levels of PDX as well as fetuin-A and SeP were determined by high-performance liquid chromatography (HPLC). Human primary hepatocytes were treated with palmitate and PDX. NF-κB pho...
Source: Clinical and Experimental Pharmacology and Physiology - June 27, 2019 Category: Drugs & Pharmacology Authors: Jung TW, Ahn SH, Shin JW, Kim HC, Park ES, Abd El-Aty AM, Hacımüftüoğlu A, Song KH, Jeong JH Tags: Clin Exp Pharmacol Physiol Source Type: research

MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2.
Abstract Colorectal cancer (CRC) is one of the most common malignancies with high levels of invasiveness, drug resistance and mortality, but the internal mechanisms of CRC are largely unknown. MicroRNAs (miRs) have been reported to be involved in the development of CRC, and numerous studied have demonstrated that the abnormal expression of miR-33a-5p might be associated with CRC. However, the function and downstream mechanism of miR-33a-5p in colorectal cancer (CRC) is remain unclear. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme involved in folic acid metabolism, was interestingly con...
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Yan Y, Zhang D, Lei T, Zhao C, Han J, Cui J, Wang Y Tags: Clin Exp Pharmacol Physiol Source Type: research

Inhibition of mitochondrial respiration by tigecycline selectively targets thyroid carcinoma and increases chemosensitivity.
This article is protected by copyright. All rights reserved. PMID: 31209921 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Wang Y, Xie F, Chen D, Wang L Tags: Clin Exp Pharmacol Physiol Source Type: research

T-bet interferes with PD-1/PD-L1-mediated suppression of CD4+ T cell inflammation and survival in Crohn's disease.
This article is protected by copyright. All rights reserved. PMID: 31210370 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Ma F, Zhao M, Song Z, Wang Z Tags: Clin Exp Pharmacol Physiol Source Type: research

Esculetin inhibits histamine-induced the expression of inflammatory cytokines and mucin in nasal epithelial cells.
This article is protected by copyright. All rights reserved. PMID: 31211861 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Sun B, Wang B, Xu M Tags: Clin Exp Pharmacol Physiol Source Type: research

Influence of renal ischemia-reperfusion injury on renal neutrophil gelatinase- associated lipocalin receptor (24p3R) in rats.
This study was undertaken to evaluate an influence of renal ischemia-reperfusion injury on 24p3R. Unilateral renal pedicle was clamped for 0, 10, 20, 30, or 45 min in male Wistar rats. Urine was collected for 24 hours after reperfusion, and ischemic kidney and blood sample were obtained. Apparent histological injury in the ischemic kidney was detected in the 30min- and 45 min-treated groups. Urinary NGAL excretion elevated in rats with renal ischemia for more than 20 min, while serum creatinine increased in rats for more than 30 min of ischemia. Renal protein expression of NGAL did not significantly change. Renal mRNA expr...
Source: Clinical and Experimental Pharmacology and Physiology - June 18, 2019 Category: Drugs & Pharmacology Authors: Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A Tags: Clin Exp Pharmacol Physiol Source Type: research

SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway.
In conclusion, our results demonstrated that SPNS2 promoted proliferation, migration and invasion, and inhibited apoptosis by regulating S1P/S1PR1/3 axis and activating Akt and ERK pathway in CRC cells. This article is protected by copyright. All rights reserved. PMID: 31206801 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 17, 2019 Category: Drugs & Pharmacology Authors: Gu X, Jiang Y, Xue W, Song C, Wang Y, Liu Y, Cui B Tags: Clin Exp Pharmacol Physiol Source Type: research

MLK3 silence induces cervical cancer cell apoptosis via the Notch-1/autophagy network.
This article is protected by copyright. All rights reserved. PMID: 31192472 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 13, 2019 Category: Drugs & Pharmacology Authors: Ma L, Cheng Y, Zeng J Tags: Clin Exp Pharmacol Physiol Source Type: research

Time evolution of methotrexate-induced kidney injury. A comparative study between different biomarkers of renal damage in rats.
This article is protected by copyright. All rights reserved. PMID: 31187885 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 12, 2019 Category: Drugs & Pharmacology Authors: Severin MJ, Campagno RV, Brandoni A, Torres AM Tags: Clin Exp Pharmacol Physiol Source Type: research

Adaptation of glycocalyx, nitric oxide synthase expression and vascular cell apoptosis in conduit arteries of tail-suspended rats.
This article is protected by copyright. All rights reserved. PMID: 31175664 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 7, 2019 Category: Drugs & Pharmacology Authors: Kang H, Wu C, Qu Y, Gao M, Zhang W, Sun A, Deng X Tags: Clin Exp Pharmacol Physiol Source Type: research

ATDC promotes the growth and invasion of hepatocellular carcinoma cells by modulating GSK-3 β/Wnt/β-catenin signaling.
This article is protected by copyright. All rights reserved. PMID: 31168819 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 6, 2019 Category: Drugs & Pharmacology Authors: Li W, Xue H, Li Y, Li P, Ma F, Liu M, Kong S Tags: Clin Exp Pharmacol Physiol Source Type: research

Effects of selective serotonin reuptake inhibitors on motility of isolated Fallopian tube.
Abstract Selective Serotonin Reuptake Inhibitiors (SSRIs) affect the smooth muscle cells acting on voltage-dependent channels for Na+, K+ and Ca2+, but their action is tissue and species specific. The aim of our study was to investigate effects of selective serotonin reuptake inhibitors on motility of the isolated Fallopian tubes. Isolated preparations of isthmus and ampoule were taken from Fallopian tubes of 20 women during hysterectomy due to uterine fibroids, and then tested for reactivity on increasing concentrations of selective serotonin reuptake inhibitors. Escitalopram (from 0.9 x 10-9 M/L to 1.4 x 10-6 M/...
Source: Clinical and Experimental Pharmacology and Physiology - June 6, 2019 Category: Drugs & Pharmacology Authors: Milosavljević MN, Janković SV, Janković SM, Djurić J, Protrka Z, Arsenijević S, Folić M, Stojadinović D, Dimitrijević A Tags: Clin Exp Pharmacol Physiol Source Type: research

Resveratrol alleviates nuclear factor- κB-mediated neuroinflammation in vasculitic peripheral neuropathy induced by ischemia-reperfusion via suppressing endoplasmic reticulum stress.
In conclusion, resveratrol alleviates VPN induced by IR. The mechanisms may involve modulating NF-κB-mediated neuroinflammation via suppressing ER stress. This article is protected by copyright. All rights reserved. PMID: 31090224 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - May 15, 2019 Category: Drugs & Pharmacology Authors: Pan PT, Lin HY, Chuang CW, Wang PK, Wan HC, Lee MC, Kao MC Tags: Clin Exp Pharmacol Physiol Source Type: research

Crumbs protein homolog 3 (CRB3) expression is associated with estrogen and progesterone receptor positivity in breast cancer.
This study detected CRB3 expression in 192 cases of breast cancer tissues and in the Molecular Taxonomy of Breast Cancer International Consortium (Metabric) and The Cancer Genome Atlas (TCGA) datasets for association with triple negative breast cancer (TNBC) phenotypes. The in vitro experiments confirm the ex vivo data. The data showed that levels of both CRB3 mRNA and protein were associated with TNBC phenotypes, i.e., 41.1% (39/95) of ER+ breast cancer was CRB3-positive, whereas 26.9% (25/93) ER- tumor was CRB3-positive (p = 0.046). Moreover, 47.6% (30/63) of PR+ breast cancer was CRB3-positive vs. 28.4% (33/116) PR- tum...
Source: Clinical and Experimental Pharmacology and Physiology - May 14, 2019 Category: Drugs & Pharmacology Authors: Li P, Zhou C, Yan Y, Li J, Liu J, Zhang Y, Liu P Tags: Clin Exp Pharmacol Physiol Source Type: research

FGF19 sustains the high proliferative ability of keratinocytes in psoriasis through the regulation of Wnt/GSK-3 β/β-catenin signaling via FGFR4.
This article is protected by copyright. All rights reserved. PMID: 31074061 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - May 9, 2019 Category: Drugs & Pharmacology Authors: Yu X, Yan N, Li Z, Hua Y, Chen W Tags: Clin Exp Pharmacol Physiol Source Type: research

Elevated plasma Pim-1 and its clinical significance in patients with pulmonary arterial hypertension.
This study was aimed to determine plasma Pim-1 levels in patients with pulmonary arterial hypertension (PAH) and to estimate the clinical value of Pim-1 as a biomarker of PAH. This was a single-center retrospective study in 111 patients with congenital heart disease (CHD) and idiopathic PAH (IPAH). Those CHD patients were divided into 2 groups: PAH associated with CHD (PAH-CHD) and CHD without PAH (nPAH-CHD). Plasma Pim-1 levels were measured by enzyme linked immunosorbent assay. 1.Plasma Pim-1 levels were significantly increased in patients with PAH-CHD and IPAH compared with the healthy control group (27.81±11.34n...
Source: Clinical and Experimental Pharmacology and Physiology - May 7, 2019 Category: Drugs & Pharmacology Authors: Zhu T, Luo J, Wang Y, Xiong X, Sheng B, Yang X, Ndongala NAMT, Li J Tags: Clin Exp Pharmacol Physiol Source Type: research

OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signaling.
This article is protected by copyright. All rights reserved. PMID: 31063653 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - May 7, 2019 Category: Drugs & Pharmacology Authors: Narasimhan G, Henderson J, Luong HT, Rajasekaran NS, Qin G, Zhang J, Krishnamurthy P Tags: Clin Exp Pharmacol Physiol Source Type: research

Fulminant Type 1 Diabetes: The Clinical and Continuous Glucose Monitoring Characteristics in Chinese Patients.
Abstract The purpose of the current study was to investigate the clinical characteristics of fulminant type 1 diabetes mellitus (FT1DM) in Chinese patients and to further determine their glycemic profiles through continuous glucose monitoring (CGM). Thirty subjects who were diagnosed with FT1DM according to the 2012 JDS criteria were enrolled. Clinical characteristics were compared to those reported in Japanese FT1DM. All subjects received retrospective CGM for 3 days after being converted to subcutaneous insulin injection therapy. Chinese FT1DM patients presented with a shorter duration of symptoms (2.84±2...
Source: Clinical and Experimental Pharmacology and Physiology - May 3, 2019 Category: Drugs & Pharmacology Authors: Ying L, Ma X, Lu J, Lu W, Zhu W, Vigersky RA, Jia W, Bao Y, Zhou J Tags: Clin Exp Pharmacol Physiol Source Type: research

Sensitivity of functional targeted neuropeptide evaluation in testing pregabalin analgesic efficacy in a rat model of osteoarthritis pain.
This study aimed to evaluate the analgesic efficacy of pregabalin (PGB) in an MIA-induced OA model in rodents by using functional and neuroproteomic pain assessment methods. Treatment group included PGB in curative intent over 9 days compared to gold standard therapy (positive controls) and placebo (negative control). Functional assessments of pain (quantitative sensory testing and operant test) were performed concomitantly with spinal neuropeptides quantification. At day 21 post-OA induction, PGB in MIA rats reduced tactile allodynia (P = 0.028) and improved the place escape/avoidance behavior (P = 0.04) compared to value...
Source: Clinical and Experimental Pharmacology and Physiology - May 2, 2019 Category: Drugs & Pharmacology Authors: Otis C, Guillot M, Moreau M, Pelletier JP, Beaudry F, Troncy E Tags: Clin Exp Pharmacol Physiol Source Type: research

Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer.
This article is protected by copyright. All rights reserved. PMID: 31034093 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 29, 2019 Category: Drugs & Pharmacology Authors: Cai J, Huang S, Yi Y, Bao S Tags: Clin Exp Pharmacol Physiol Source Type: research