Diagnosis of Lumbar Spondylolisthesis Using a Pruned CNN Model
Comput Math Methods Med. 2022 May 10;2022:2722315. doi: 10.1155/2022/2722315. eCollection 2022.ABSTRACTConvolutional neural network (CNN) models have made tremendous progress in the medical domain in recent years. The application of the CNN model is restricted due to a huge number of redundant and unnecessary parameters. In this paper, the weight and unit pruning strategy are used to reduce the complexity of the CNN model so that it can be used on small devices for the diagnosis of lumbar spondylolisthesis. Experimental results reveal that by removing 90% of network load, the unit pruning strategy outperforms weight prunin...
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Deepika Saravagi Shweta Agrawal Manisha Saravagi Md Habibur Rahman Source Type: research

Development of a Bile Acid-Related Gene Signature for Predicting Survival in Patients with Hepatocellular Carcinoma
CONCLUSION: The three-gene prediction model was more reliable than the pathological staging characters of the tumor for the prognosis and survival of patients with HCC. In addition, the upregulated genes facilitating the transport of BAs are associated with poor prognosis of patients with HCC, and genes of de novo synthesis of BAs benefit patients with HCC.PMID:35592684 | PMC:PMC9113879 | DOI:10.1155/2022/9076175 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Gang Wang Jun Guan Qin Yang Fengtian Wu Junwei Shao Qihui Zhou Zixuan Guo Yanli Ren Haihong Zhu Zhi Chen Source Type: research

High-Concentration Metformin Reduces Oxidative Stress Injury and Inhibits the Growth and Migration of Clear Cell Renal Cell Carcinoma
CONCLUSION: High-concentration metformin can reduce oxidative stress injury, increase the expression of SOD in CCRCC, and reduce cyclin D in CCRCC to inhibit proliferation and migration, which has optimistic prospects and application value in controlling the progression of CCRCC.PMID:35592685 | PMC:PMC9113878 | DOI:10.1155/2022/1466991 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Yang Liu Jianwei Li Miaomiao Song Guisong Qi Lingling Meng Source Type: research

Diagnosis of Lumbar Spondylolisthesis Using a Pruned CNN Model
Comput Math Methods Med. 2022 May 10;2022:2722315. doi: 10.1155/2022/2722315. eCollection 2022.ABSTRACTConvolutional neural network (CNN) models have made tremendous progress in the medical domain in recent years. The application of the CNN model is restricted due to a huge number of redundant and unnecessary parameters. In this paper, the weight and unit pruning strategy are used to reduce the complexity of the CNN model so that it can be used on small devices for the diagnosis of lumbar spondylolisthesis. Experimental results reveal that by removing 90% of network load, the unit pruning strategy outperforms weight prunin...
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Deepika Saravagi Shweta Agrawal Manisha Saravagi Md Habibur Rahman Source Type: research

Development of a Bile Acid-Related Gene Signature for Predicting Survival in Patients with Hepatocellular Carcinoma
CONCLUSION: The three-gene prediction model was more reliable than the pathological staging characters of the tumor for the prognosis and survival of patients with HCC. In addition, the upregulated genes facilitating the transport of BAs are associated with poor prognosis of patients with HCC, and genes of de novo synthesis of BAs benefit patients with HCC.PMID:35592684 | PMC:PMC9113879 | DOI:10.1155/2022/9076175 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Gang Wang Jun Guan Qin Yang Fengtian Wu Junwei Shao Qihui Zhou Zixuan Guo Yanli Ren Haihong Zhu Zhi Chen Source Type: research

High-Concentration Metformin Reduces Oxidative Stress Injury and Inhibits the Growth and Migration of Clear Cell Renal Cell Carcinoma
CONCLUSION: High-concentration metformin can reduce oxidative stress injury, increase the expression of SOD in CCRCC, and reduce cyclin D in CCRCC to inhibit proliferation and migration, which has optimistic prospects and application value in controlling the progression of CCRCC.PMID:35592685 | PMC:PMC9113878 | DOI:10.1155/2022/1466991 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 20, 2022 Category: Statistics Authors: Yang Liu Jianwei Li Miaomiao Song Guisong Qi Lingling Meng Source Type: research

Paeoniflorin Can Improve Acute Lung Injury Caused by Severe Acute Pancreatitis through Nrf2/ARE Pathway
CONCLUSION: Paeoniflorin may improve acute lung injury in rats with severe pancreatitis by inhibiting inflammation and oxidative stress response. These effects may be related to activating the Nrf2/ARE signaling pathway.PMID:35586665 | PMC:PMC9110196 | DOI:10.1155/2022/5712219 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Yanyan Hu Wei Yang Source Type: research

Drug-Drug Interactions Prediction Using Fingerprint Only
In this study, we proposed a simple computational method to predict DDIs. In this method, drugs were represented by their fingerprint features, which are most widely used in investigating drug-related problems. These features were refined by three models, including addition, subtraction, and Hadamard models, to generate the representation of DDIs. The powerful classification algorithm, random forest, was picked up to build the classifier. The results of two types of tenfold cross-validation on the classifier indicated good performance for discovering novel DDIs among known drugs and acceptable performance for identifying D...
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Bing Ran Lei Chen Meijing Li Yujuan Han Qi Dai Source Type: research

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis
CONCLUSIONS: The PNI was an independent predicting factor of 30-day, 90-day, and 1-year mortality of the critically ill patients with stroke. In addition, there was a U-shaped relationship between PNI and all-cause mortality of stroke patients. PNI was a risk factor for the outcome of stroke when PNI was >49.4, while PNI was a protective factor for outcome of stroke when PNI was <49.4.PMID:35586667 | PMC:PMC9110188 | DOI:10.1155/2022/4889920 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Yang Liu Xiaobin Yang Sultan Kadasah Chaosheng Peng Source Type: research

Efficacy and Safety of PD-1/PD-L1 Inhibitor Chemotherapy Combined with Lung Cancer Fang No. 1 in Relapsed and Refractory SCLC: A Retrospective Observational Study
CONCLUSION: PD-1/PD-L1 inhibitor chemotherapy combined with Lung Cancer Fang No. 1 has a good and safe effect on SCLC patients. It has a good curative effect in improving the clinical symptoms of patients. It can stabilize the tumor, inhibit the development of lung cancer, improve the body's cellular immune function, adjust the level and expression of tumor markers, improve the body's material metabolism, and restore the balance of yin and yang in the body.PMID:35586668 | PMC:PMC9110176 | DOI:10.1155/2022/2848220 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Lihua Wang Xiaoxia Lei Xin Wang Source Type: research

The Effect of Physical Exercise on the Elderly's Anxiety: Based on Systematic Reviews and Meta-Analysis
CONCLUSION: Physical exercise plays an important role in reducing the anxiety of the elderly. Therefore, regular physical exercise can be regarded as part of the elderly pension plan, but more high-quality research is needed to further explore the impact of physical exercise on elderly anxiety.PMID:35586669 | PMC:PMC9110195 | DOI:10.1155/2022/4848290 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Feilong Wu Junling Zhang Haiying Yang Juan Jiang Source Type: research

Clinical Effect of Side-Approach Laparoscopic Splenectomy for Neuropathic Splenomegaly
CONCLUSION: The treatment of lateral laparoscopic splenectomy is very safe and effective and has obvious advantages, because it can reduce the occurrence of postoperative complications and provide a good basis for the recovery of patients. It is worthy to be widely used in clinical splenic surgery.PMID:35586670 | PMC:PMC9110186 | DOI:10.1155/2022/1224916 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Zhao Yuan Hua Song An Bo Yang Hai Qing Li Yuan Wang Jian Wang Source Type: research

Analysis of Multifactor-Driven Myopia Disease Modules to Guide Personalized Treatment and Drug Development
Comput Math Methods Med. 2022 May 9;2022:5262259. doi: 10.1155/2022/5262259. eCollection 2022.ABSTRACTMyopia is recognized as a multifactor, multicascade complex disease. However, people still know little about the pathogenesis of myopia. Therefore, we aim to guide the personalized treatment, drug research, and development of myopia. Here, based on the interaction network of myopia-related genes, this study constructed a multifactor-driven myopia disease module map. We first identified differentially expressed (DE) miRNAs in myopia. Then, we constructed a myopia-related protein interaction network targeted by these DE miRN...
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Shiliang Liu Fei Li Source Type: research

Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma
In conclusion, the combination administration of TSAIII and PTX had a significantly therapeutic effect on NPC and avoided the PTX's side effects, which may have acted as a new direction for the study of therapeutic approaches for NPC clinically.PMID:35586672 | PMC:PMC9110172 | DOI:10.1155/2022/6756676 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Xiaofeng Li Wen Lu Tianjiao Zhou Feng Zhao Li Yang Source Type: research

Diagnosis of Heart Failure Complicated with Sleep Apnea Syndrome by Thoracic Computerized Tomography under Artificial Intelligence Algorithm
Comput Math Methods Med. 2022 May 9;2022:3795097. doi: 10.1155/2022/3795097. eCollection 2022.ABSTRACTThe aim of this study was to explore the application effect of thoracic computerized tomography (CT) under single threshold segmentation algorithm in the diagnosis of heart failure (HF) complicated with sleep apnea syndrome. 30 patients diagnosed with HF complicated with sleep apnea syndrome were chosen for the research. Another 30 patients without sleep apnea syndrome were selected as the control group, whose age, height, and weight were similar to those of the experimental group. Then, a model for thoracic CT image segme...
Source: Computational and Mathematical Methods in Medicine - May 19, 2022 Category: Statistics Authors: Weihong Tian Jinghua Li Lan Ma Source Type: research