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Effect of Rainfall for the Dynamical Transmission Model of the Dengue Disease in Thailand.
Authors: Chanprasopchai P, Pongsumpun P, Tang IM Abstract The SEIR (Susceptible-Exposed-Infected-Recovered) model is used to describe the transmission of dengue virus. The main contribution is determining the role of the rainfall in Thailand in the model. The transmission of dengue disease is assumed to depend on the nature of the rainfall in Thailand. We analyze the dynamic transmission of dengue disease. The stability of the solution of the model is analyzed. It is investigated by using the Routh-Hurwitz criteria. We find two equilibrium states: a disease-free state and an endemic equilibrium state. The basic rep...
Source: Computational and Mathematical Methods in Medicine - September 22, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Mechanistic Model for Cancer Growth and Response to Chemotherapy.
Authors: Simbawa E Abstract Cancer treatment has developed over the years; however not all patients respond to this treatment, and therefore further research is needed. In this paper, we employ mathematical modeling to understand the behavior of cancer and its interaction with therapy. We study a drug delivery and drug-cell interaction model along with cell proliferation. Due to the fact that cancer cells grow when there are enough nutrients and oxygen, proliferation can be a barrier against a response to therapy. To understand the effect of this factor, we perform numerical simulations of the model for different v...
Source: Computational and Mathematical Methods in Medicine - September 22, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Sensitivity Analysis of the Integral Quality Monitoring System ® Using Monte Carlo Simulation.
Sensitivity Analysis of the Integral Quality Monitoring System® Using Monte Carlo Simulation. Comput Math Methods Med. 2017;2017:7025281 Authors: Oderinde OM, du Plessis FCP Abstract The Integral Quality Monitoring (IQM) System is a real-time beam output verifying system that validates the integrity and accuracy of patient treatment plan (TP) data during radiation treatment. The purpose of this study was to evaluate the sensitivity of the IQM to errors in segment using EGSnrc/BEAMnrc Monte Carlo (MC) codes. Sensitivity analysis (SA) techniques were applied to study the significance of small alterat...
Source: Computational and Mathematical Methods in Medicine - September 22, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Segmentation of Left and Right Ventricles in Cardiac MRI Using Active Contours.
Authors: Soomro S, Akram F, Munir A, Lee CH, Choi KN Abstract Segmentation of left and right ventricles plays a crucial role in quantitatively analyzing the global and regional information in the cardiac magnetic resonance imaging (MRI). In MRI, the intensity inhomogeneity and weak or blurred object boundaries are the problems, which makes it difficult for the intensity-based segmentation methods to properly delineate the regions of interests (ROI). In this paper, a hybrid signed pressure force function (SPF) is proposed, which yields both local and global image fitted differences in an additive fashion. A characte...
Source: Computational and Mathematical Methods in Medicine - September 22, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Dendritic Immunotherapy Improvement for an Optimal Control Murine Model.
Authors: Rangel-Reyes JC, Chimal-Eguía JC, Castillo-Montiel E Abstract Therapeutic protocols in immunotherapy are usually proposed following the intuition and experience of the therapist. In order to deduce such protocols mathematical modeling, optimal control and simulations are used instead of the therapist's experience. Clinical efficacy of dendritic cell (DC) vaccines to cancer treatment is still unclear, since dendritic cells face several obstacles in the host environment, such as immunosuppression and poor transference to the lymph nodes reducing the vaccine effect. In view of that, we have created a m...
Source: Computational and Mathematical Methods in Medicine - September 17, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Products of Compartmental Models in Epidemiology.
Authors: Worden L, Porco TC Abstract We show that many structured epidemic models may be described using a straightforward product structure in this paper. Such products, derived from products of directed graphs, may represent useful refinements including geographic and demographic structure, age structure, gender, risk groups, or immunity status. Extension to multistrain dynamics, that is, pathogen heterogeneity, is also shown to be feasible in this framework. Systematic use of such products may aid in model development and exploration, can yield insight, and could form the basis of a systematic approach to numeri...
Source: Computational and Mathematical Methods in Medicine - September 14, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Computational and Mathematical Methods to Estimate the Basic Reproduction Number and Final Size for Single-Stage and Multistage Progression Disease Models for Zika with Preventative Measures.
We present new mathematical models that include the impact of using selected preventative measures such as insecticide treated nets (ITN) in controlling or ameliorating the spread of the Zika virus. For these models, we derive the basic reproduction number and sharp estimates for the final size relation. We first present a single-stage model which is later extended to a new multistage model for Zika that incorporates more realistic incubation stages for both the humans and vectors. For each of these models, we derive a basic reproduction number and a final size relation estimate. We observe that the basic reproduction numb...
Source: Computational and Mathematical Methods in Medicine - September 13, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4.
Authors: Tang S, Ma W, Bai P Abstract The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equi...
Source: Computational and Mathematical Methods in Medicine - September 13, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Several Indicators of Critical Transitions for Complex Diseases Based on Stochastic Analysis.
Authors: Wang G, Li Y, Zou X Abstract Many complex diseases (chronic disease onset, development and differentiation, self-assembly, etc.) are reminiscent of phase transitions in a dynamical system: quantitative changes accumulate largely unnoticed until a critical threshold is reached, which causes abrupt qualitative changes of the system. Understanding such nonlinear behaviors is critical to dissect the multiple genetic/environmental factors that together shape the genetic and physiological landscape underlying basic biological functions and to identify the key driving molecules. Based on stochastic differential e...
Source: Computational and Mathematical Methods in Medicine - August 25, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Multicriteria Approach to Find Predictive and Sparse Models with Stable Feature Selection for High-Dimensional Data.
Authors: Bommert A, Rahnenführer J, Lang M Abstract Finding a good predictive model for a high-dimensional data set can be challenging. For genetic data, it is not only important to find a model with high predictive accuracy, but it is also important that this model uses only few features and that the selection of these features is stable. This is because, in bioinformatics, the models are used not only for prediction but also for drawing biological conclusions which makes the interpretability and reliability of the model crucial. We suggest using three target criteria when fitting a predictive model to a high...
Source: Computational and Mathematical Methods in Medicine - August 25, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Integration of Multiple Genomic Data Sources in a Bayesian Cox Model for Variable Selection and Prediction.
Authors: Treppmann T, Ickstadt K, Zucknick M Abstract Bayesian variable selection becomes more and more important in statistical analyses, in particular when performing variable selection in high dimensions. For survival time models and in the presence of genomic data, the state of the art is still quite unexploited. One of the more recent approaches suggests a Bayesian semiparametric proportional hazards model for right censored time-to-event data. We extend this model to directly include variable selection, based on a stochastic search procedure within a Markov chain Monte Carlo sampler for inference. This equips...
Source: Computational and Mathematical Methods in Medicine - August 24, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Probing for Sparse and Fast Variable Selection with Model-Based Boosting.
We present a new variable selection method based on model-based gradient boosting and randomly permuted variables. Model-based boosting is a tool to fit a statistical model while performing variable selection at the same time. A drawback of the fitting lies in the need of multiple model fits on slightly altered data (e.g., cross-validation or bootstrap) to find the optimal number of boosting iterations and prevent overfitting. In our proposed approach, we augment the data set with randomly permuted versions of the true variables, so-called shadow variables, and stop the stepwise fitting as soon as such a variable would be ...
Source: Computational and Mathematical Methods in Medicine - August 24, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

An Update on Statistical Boosting in Biomedicine.
Authors: Mayr A, Hofner B, Waldmann E, Hepp T, Meyer S, Gefeller O Abstract Statistical boosting algorithms have triggered a lot of research during the last decade. They combine a powerful machine learning approach with classical statistical modelling, offering various practical advantages like automated variable selection and implicit regularization of effect estimates. They are extremely flexible, as the underlying base-learners (regression functions defining the type of effect for the explanatory variables) can be combined with any kind of loss function (target function to be optimized, defining the type of regr...
Source: Computational and Mathematical Methods in Medicine - August 24, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Multiscale Model for the World's First Parasitic Disease Targeted for Eradication: Guinea Worm Disease.
Authors: Netshikweta R, Garira W Abstract Guinea worm disease (GWD) is both a neglected tropical disease and an environmentally driven infectious disease. Environmentally driven infectious diseases remain one of the biggest health threats for human welfare in developing countries and the threat is increased by the looming danger of climate change. In this paper we present a multiscale model of GWD that integrates the within-host scale and the between-host scale. The model is used to concurrently examine the interactions between the three organisms that are implicated in natural cases of GWD transmission, the copepo...
Source: Computational and Mathematical Methods in Medicine - August 18, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

NSiteMatch: Prediction of Binding Sites of Nucleotides by Identifying the Structure Similarity of Local Surface Patches.
In this study, we propose a nucleotide-binding site predictor, namely, NSiteMatch. The NSiteMatch algorithm integrates three different strategies: geometrical analysis, energy calculation, and template comparison. Unlike a traditional template-based predictor, which identifies global similarity between target structure and template, NSiteMatch concerns the local similarity between a surface patch of the target protein and the binding sites of template. To this end, NSiteMatch identifies more templates than traditional template-based predictors. The NSiteMatch predictor is compared with three representative methods, Findsit...
Source: Computational and Mathematical Methods in Medicine - August 18, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Convolutional Neural Network for the Detection of End-Diastole and End-Systole Frames in Free-Breathing Cardiac Magnetic Resonance Imaging.
Authors: Yang F, He Y, Hussain M, Xie H, Lei P Abstract Free-breathing cardiac magnetic resonance (CMR) imaging has short examination time with high reproducibility. Detection of the end-diastole and the end-systole frames of the free-breathing cardiac magnetic resonance, supplemented by visual identification, is time consuming and laborious. We propose a novel method for automatic identification of both the end-diastole and the end-systole frames, in the free-breathing CMR imaging. The proposed technique utilizes the convolutional neural network to locate the left ventricle and to obtain the end-diastole and the e...
Source: Computational and Mathematical Methods in Medicine - August 18, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Computational Paradigms for Mental Health.
Authors: Cipresso P, Matic A, Lopez G, Serino S PMID: 28814966 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - August 18, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Kalman Filtering for Genetic Regulatory Networks with Missing Values.
Authors: Lin Q, Liu Q, Lai T, Wang W Abstract The filter problem with missing value for genetic regulation networks (GRNs) is addressed, in which the noises exist in both the state dynamics and measurement equations; furthermore, the correlation between process noise and measurement noise is also taken into consideration. In order to deal with the filter problem, a class of discrete-time GRNs with missing value, noise correlation, and time delays is established. Then a new observation model is proposed to decrease the adverse effect caused by the missing value and to decouple the correlation between process noise a...
Source: Computational and Mathematical Methods in Medicine - August 18, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Improved k-t PCA Algorithm Using Artificial Sparsity in Dynamic MRI.
Authors: Wang Y, Chen Z, Wang J, Yuan L, Xia L, Liu F Abstract The k-t principal component analysis (k-t PCA) is an effective approach for high spatiotemporal resolution dynamic magnetic resonance (MR) imaging. However, it suffers from larger residual aliasing artifacts and noise amplification when the reduction factor goes higher. To further enhance the performance of this technique, we propose a new method called sparse k-t PCA that combines the k-t PCA algorithm with an artificial sparsity constraint. It is a self-calibrated procedure that is based on the traditional k-t PCA method by further eliminating the rec...
Source: Computational and Mathematical Methods in Medicine - August 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study.
Authors: Bromis K, Gkiatis K, Karanasiou I, Matsopoulos G, Karavasilis E, Papathanasiou M, Efstathopoulos E, Kelekis N, Kouloulias V Abstract Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, inc...
Source: Computational and Mathematical Methods in Medicine - August 13, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies.
Authors: Friedrichs S, Manitz J, Burger P, Amos CI, Risch A, Chang-Claude J, Wichmann HE, Kneib T, Bickeböller H, Hofner B Abstract The analysis of genome-wide association studies (GWAS) benefits from the investigation of biologically meaningful gene sets, such as gene-interaction networks (pathways). We propose an extension to a successful kernel-based pathway analysis approach by integrating kernel functions into a powerful algorithmic framework for variable selection, to enable investigation of multiple pathways simultaneously. We employ genetic similarity kernels from the logistic kernel machine test (LKMT...
Source: Computational and Mathematical Methods in Medicine - August 10, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Mathematical Modeling for Inherited Diseases.
Authors: Anis S, Khan M, Khan S Abstract We introduced a new nonassociative algebra, namely, left almost algebra, and discussed some of its genetic properties. We discussed the relation of this algebra with flexible algebra, Jordan algebra, and generalized Jordan algebra. PMID: 28781606 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - August 8, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Monte Carlo Study of the Photon Spectrum due to the Different Materials Used in the Construction of Flattening Filters of LINAC.
Authors: Jiménez JSE, Lagos MD, Martinez-Ovalle SA Abstract Different types the spectrum of photons were studied; they were emitted from the flattening filter of a LINAC Varian 2100 C/D that operates at 15 MV. The simplified geometry of the LINAC head was calculated using the MCNPX code based on the studies of the materials of the flattening filter, namely, SST, W, Pb, Fe, Ta, Al, and Cu. These materials were replaced in the flattening filter to calculate the photon spectra at the output of this device to obtain the spectrum that makes an impact with the patient. The different spectra obtained were an...
Source: Computational and Mathematical Methods in Medicine - August 5, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination.
Authors: Miao A, Zhang J, Zhang T, Pradeep BGSA Abstract A stochastic SIR model with vertical transmission and vaccination is proposed and investigated in this paper. The threshold dynamics are explored when the noise is small. The conditions for the extinction or persistence of infectious diseases are deduced. Our results show that large noise can lead to the extinction of infectious diseases which is conducive to epidemic diseases control. PMID: 28761501 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - August 3, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Corrigendum to "A Clinical Decision Support System for the Diagnosis, Fracture Risks and Treatment of Osteoporosis".
Corrigendum to "A Clinical Decision Support System for the Diagnosis, Fracture Risks and Treatment of Osteoporosis". Comput Math Methods Med. 2017;2017:5472789 Authors: Halldorsson BV, Bjornsson AH, Gudmundsson HT, Birgisson EO, Ludviksson BR, Gudbjornsson B Abstract [This corrects the article DOI: 10.1155/2015/189769.]. PMID: 28751924 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 29, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Optimization of Classification Strategies of Acetowhite Temporal Patterns towards Improving Diagnostic Performance of Colposcopy.
Authors: Gutiérrez-Fragoso K, Acosta-Mesa HG, Cruz-Ramírez N, Hernández-Jiménez R Abstract Efforts have been being made to improve the diagnostic performance of colposcopy, trying to help better diagnose cervical cancer, particularly in developing countries. However, improvements in a number of areas are still necessary, such as the time it takes to process the full digital image of the cervix, the performance of the computing systems used to identify different kinds of tissues, and biopsy sampling. In this paper, we explore three different, well-known automatic classification methods (k...
Source: Computational and Mathematical Methods in Medicine - July 28, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Selective Ensemble Classification Method Combining Mammography Images with Ultrasound Images for Breast Cancer Diagnosis.
Authors: Cong J, Wei B, He Y, Yin Y, Zheng Y Abstract Breast cancer has been one of the main diseases that threatens women's life. Early detection and diagnosis of breast cancer play an important role in reducing mortality of breast cancer. In this paper, we propose a selective ensemble method integrated with the KNN, SVM, and Naive Bayes to diagnose the breast cancer combining ultrasound images with mammography images. Our experimental results have shown that the selective classification method with an accuracy of 88.73% and sensitivity of 97.06% is efficient for breast cancer diagnosis. And indicator R presents a...
Source: Computational and Mathematical Methods in Medicine - July 26, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Mathematical Simulation of Transport Kinetics of Tumor-Imaging Radiopharmaceutical (99m)Tc-MIBI.
Authors: Shevtsova ON, Shevtsova VK Abstract The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical (99m)Tc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at early time point and late time point of the scanning, and the obtained data can be used for determination of the washout rate coefficient which is one of the existing oncology diag...
Source: Computational and Mathematical Methods in Medicine - July 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

An Exercise Health Simulation Method Based on Integrated Human Thermophysiological Model.
Authors: Jia N, Chen X, Yu L, Wang R, Yang K, Luo X Abstract Research of healthy exercise has garnered a keen research for the past few years. It is known that participation in a regular exercise program can help improve various aspects of cardiovascular function and reduce the risk of suffering from illness. But some exercise accidents like dehydration, exertional heatstroke, and even sudden death need to be brought to attention. If these exercise accidents can be analyzed and predicted before they happened, it will be beneficial to alleviate or avoid disease or mortality. To achieve this objective, an exercise he...
Source: Computational and Mathematical Methods in Medicine - July 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Automatic Detection of Epilepsy and Seizure Using Multiclass Sparse Extreme Learning Machine Classification.
Authors: Wang Y, Li Z, Feng L, Zheng C, Zhang W Abstract An automatic detection system for distinguishing normal, ictal, and interictal electroencephalogram (EEG) signals is of great help in clinical practice. This paper presents a three-class classification system based on discrete wavelet transform (DWT) and the nonlinear sparse extreme learning machine (SELM) for epilepsy and epileptic seizure detection. Three-level lifting DWT using Daubechies order 4 wavelet is introduced to decompose EEG signals into delta, theta, alpha, and beta subbands. Considering classification accuracy and computational complexity, the ...
Source: Computational and Mathematical Methods in Medicine - July 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Sparse Representation Based Multi-Instance Learning for Breast Ultrasound Image Classification.
Authors: Bing L, Wang W Abstract We propose a novel method based on sparse representation for breast ultrasound image classification under the framework of multi-instance learning (MIL). After image enhancement and segmentation, concentric circle is used to extract the global and local features for improving the accuracy in diagnosis and prediction. The classification problem of ultrasound image is converted to sparse representation based MIL problem. Each instance of a bag is represented as a sparse linear combination of all basis vectors in the dictionary, and then the bag is represented by one feature vector whi...
Source: Computational and Mathematical Methods in Medicine - July 12, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

SIFT Based Vein Recognition Models: Analysis and Improvement.
Authors: Wang G, Wang J Abstract Scale-Invariant Feature Transform (SIFT) is being investigated more and more to realize a less-constrained hand vein recognition system. Contrast enhancement (CE), compensating for deficient dynamic range aspects, is a must for SIFT based framework to improve the performance. However, evidence of negative influence on SIFT matching brought by CE is analysed by our experiments. We bring evidence that the number of extracted keypoints resulting by gradient based detectors increases greatly with different CE methods, while on the other hand the matching result of extracted invariant de...
Source: Computational and Mathematical Methods in Medicine - July 8, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Exponentially Modified Peak Functions in Biomedical Sciences and Related Disciplines.
Authors: Golubev A Abstract In many cases relevant to biomedicine, a variable time, which features a certain distribution, is required for objects of interest to pass from an initial to an intermediate state, out of which they exit at random to a final state. In such cases, the distribution of variable times between exiting the initial and entering the final state must conform to the convolution of the first distribution and a negative exponential distribution. A common example is the exponentially modified Gaussian (EMG), which is widely used in chromatography for peak analysis and is long known as ex-Gaussian in ...
Source: Computational and Mathematical Methods in Medicine - July 6, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Analysis of Urine Flow in Three Different Ureter Models.
In this study, we investigated urine flow in the abnormal situation. We made three different, curved tubular, funnel-shaped, and undulated ureter models that were based on human anatomy. A numerical analysis of the urine flow rate and pattern in the ureter was performed for a combination of the three different ureters, with and without a ureteral stenosis and with four different types of double J stents. The three ureters showed a difference in urine flow rate and pattern. Luminal flow rate was affected by ureter shape. The side holes of a double J stent played a different role in detour, which depended on ureter geometry....
Source: Computational and Mathematical Methods in Medicine - July 1, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Feasibility Study of Geometric-Decomposition Coil Compression in MRI Radial Acquisitions.
Authors: Wang J, Chen Z, Wang Y, Yuan L, Xia L Abstract Receiver arrays with a large number of coil elements are becoming progressively available because of their increased signal-to-noise ratio (SNR) and enhanced parallel imaging performance. However, longer reconstruction time and intensive computational cost have become significant concerns as the number of channels increases, especially in some iterative reconstructions. Coil compression can effectively solve this problem by linearly combining the raw data from multiple coils into fewer virtual coils. In this work, geometric-decomposition coil compression (GCC)...
Source: Computational and Mathematical Methods in Medicine - July 1, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Finding Solvable Units of Variables in Nonlinear ODEs of ECM Degradation Pathway Network.
Authors: Kawasaki S, Minerva D, Itano K, Suzuki T Abstract We consider ordinary differential equation (ODE) model for a pathway network that arises in extracellular matrix (ECM) degradation. For solving the ODEs, we propose applying the mass conservation law (MCL), together with a stoichiometry called doubling rule, to them. Then it leads to extracting new units of variables in the ODEs that can be solved explicitly, at least in principle. The simulation results for the ODE solutions show that the numerical solutions are indeed in good accord with theoretical solutions and satisfy the MALs. PMID: 28638440 [PubM...
Source: Computational and Mathematical Methods in Medicine - June 25, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Defining an Optimal Cut-Point Value in ROC Analysis: An Alternative Approach.
In this study, a new approach, alternative to these methods, is proposed. The proposed approach is based on the value of the area under the ROC curve. This method defines the optimal cut-point value as the value whose sensitivity and specificity are the closest to the value of the area under the ROC curve and the absolute value of the difference between the sensitivity and specificity values is minimum. This approach is very practical. In this study, the results of the proposed method are compared with those of the standard approaches, by using simulated data with different distribution and homogeneity conditions as well a...
Source: Computational and Mathematical Methods in Medicine - June 25, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Weighted Polynomial Approximation for Automated Detection of Inspiratory Flow Limitation.
This study involved investigating a real-time algorithm for detecting IFL during sleep. Three categories of inspiratory flow shape were collected from previous studies for use as a development set. Of these, 16 cases were labeled as non-IFL and 78 as IFL which were further categorized into minor level (20 cases) and severe level (58 cases) of obstruction. In this study, algorithms using polynomial functions were proposed for extracting the features of IFL. Methods using first- to third-order polynomial approximations were applied to calculate the fitting curve to obtain the mean absolute error. The proposed algorithm is de...
Source: Computational and Mathematical Methods in Medicine - June 22, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Inference of Biochemical S-Systems via Mixed-Variable Multiobjective Evolutionary Optimization.
Authors: Chen Y, Chen D, Zou X Abstract Inference of the biochemical systems (BSs) via experimental data is important for understanding how biochemical components in vivo interact with each other. However, it is not a trivial task because BSs usually function with complex and nonlinear dynamics. As a popular ordinary equation (ODE) model, the S-System describes the dynamical properties of BSs by incorporating the power rule of biochemical reactions but behaves as a challenge because it has a lot of parameters to be confirmed. This work is dedicated to proposing a general method for inference of S-Systems by experim...
Source: Computational and Mathematical Methods in Medicine - June 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

The Preventive Control of Zoonotic Visceral Leishmaniasis: Efficacy and Economic Evaluation.
Authors: Shimozako HJ, Wu J, Massad E Abstract Zoonotic Visceral Leishmaniasis (ZVL) is one of the world's deadliest and neglected infectious diseases, according to World Health Organization. This disease is one of major human and veterinary medical significance. The sandfly and the reservoir in urban areas remain among the major challenges for the control activities. In this paper, we evaluated five control strategies (positive dog elimination, insecticide impregnated dog collar, dog vaccination, dog treatment, and sandfly population control), considering disease control results and cost-effectiveness. We elaborat...
Source: Computational and Mathematical Methods in Medicine - June 9, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Box-Counting Method of 2D Neuronal Image: Method Modification and Quantitative Analysis Demonstrated on Images from the Monkey and Human Brain.
This study calls attention to the difference between traditional box-counting method and its modification. The appropriate scaling factor, influence on image size and resolution, and image rotation, as well as different image presentation, are showed on the sample of asymmetrical neurons from the monkey dentate nucleus. The standard BC method and its modification were evaluated on the sample of 2D neuronal images from the human neostriatum. In addition, three box dimensions (which estimate the space-filling property, the shape, complexity, and the irregularity of dendritic tree) were used to evaluate differences in the mor...
Source: Computational and Mathematical Methods in Medicine - June 2, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Systems Dynamic Model for Drug Abuse and Drug-Related Crime in the Western Cape Province of South Africa.
Authors: Nyabadza F, Coetzee L Abstract The complex problem of drug abuse and drug-related crimes in communities in the Western Cape province cannot be studied in isolation but through the system they are embedded in. In this paper, a theoretical model to evaluate the syndemic of substance abuse and drug-related crimes within the Western Cape province of South Africa is constructed and explored. The dynamics of drug abuse and drug-related crimes within the Western Cape are simulated using STELLA software. The simulation results are consistent with the data from SACENDU and CrimeStats SA, highlighting the usefulness...
Source: Computational and Mathematical Methods in Medicine - June 1, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Mini Electrodes on Ablation Catheters: Valuable Addition or Redundant Information?-Insights from a Computational Study.
In conclusion, catheters with mini electrodes bring about additional benefit to distinguish ablated tissue from nonablated tissue in parallel position with high spatial resolution. It is feasible to detect conduction gaps in linear lesions with this catheter by evaluating electrogram data from mini electrodes. PMID: 28553365 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 30, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Dysphonic Voice Pattern Analysis of Patients in Parkinson's Disease Using Minimum Interclass Probability Risk Feature Selection and Bagging Ensemble Learning Methods.
Authors: Wu Y, Chen P, Yao Y, Ye X, Xiao Y, Liao L, Wu M, Chen J Abstract Analysis of quantified voice patterns is useful in the detection and assessment of dysphonia and related phonation disorders. In this paper, we first study the linear correlations between 22 voice parameters of fundamental frequency variability, amplitude variations, and nonlinear measures. The highly correlated vocal parameters are combined by using the linear discriminant analysis method. Based on the probability density functions estimated by the Parzen-window technique, we propose an interclass probability risk (ICPR) method to select the...
Source: Computational and Mathematical Methods in Medicine - May 30, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Novel Remote Rehabilitation System with the Fusion of Noninvasive Wearable Device and Motion Sensing for Pulmonary Patients.
Authors: Tey CK, An J, Chung WY Abstract Chronic obstructive pulmonary disease is a type of lung disease caused by chronically poor airflow that makes breathing difficult. As a chronic illness, it typically worsens over time. Therefore, pulmonary rehabilitation exercises and patient management for extensive periods of time are required. This paper presents a remote rehabilitation system for a multimodal sensors-based application for patients who have chronic breathing difficulties. The process involves the fusion of sensory data-captured motion data by stereo-camera and photoplethysmogram signal by a wearable PPG s...
Source: Computational and Mathematical Methods in Medicine - May 30, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

IPF-LASSO: Integrative L1-Penalized Regression with Penalty Factors for Prediction Based on Multi-Omics Data.
Authors: Boulesteix AL, De Bin R, Jiang X, Fuchs M Abstract As modern biotechnologies advance, it has become increasingly frequent that different modalities of high-dimensional molecular data (termed "omics" data in this paper), such as gene expression, methylation, and copy number, are collected from the same patient cohort to predict the clinical outcome. While prediction based on omics data has been widely studied in the last fifteen years, little has been done in the statistical literature on the integration of multiple omics modalities to select a subset of variables for prediction, which is a critic...
Source: Computational and Mathematical Methods in Medicine - May 27, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

A Web-Based Tool for Automatic Data Collection, Curation, and Visualization of Complex Healthcare Survey Studies including Social Network Analysis.
Authors: Benítez JA, Labra JE, Quiroga E, Martín V, García I, Marqués-Sánchez P, Benavides C Abstract There is a great concern nowadays regarding alcohol consumption and drug abuse, especially in young people. Analyzing the social environment where these adolescents are immersed, as well as a series of measures determining the alcohol abuse risk or personal situation and perception using a number of questionnaires like AUDIT, FAS, KIDSCREEN, and others, it is possible to gain insight into the current situation of a given individual regarding his/her consumption behavior. But this ...
Source: Computational and Mathematical Methods in Medicine - May 23, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Cuffless Blood Pressure Estimation Based on Data-Oriented Continuous Health Monitoring System.
Authors: Atomi K, Kawanaka H, Bhuiyan MS, Oguri K Abstract Measuring blood pressure continuously helps monitor health and also prevent lifestyle related diseases to extend the expectancy of healthy life. Blood pressure, which is nowadays used for monitoring patient, is one of the most useful indexes for prevention of lifestyle related diseases such as hypertension. However, continuously monitoring the blood pressure is unrealistic because of discomfort caused by the tightening of a cuff belt. We have earlier researched the data-oriented blood pressure estimation without using a cuff. Remarkably, our blood pressure ...
Source: Computational and Mathematical Methods in Medicine - May 20, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Automated Detection of Red Lesions Using Superpixel Multichannel Multifeature.
Authors: Zhou W, Wu C, Chen D, Wang Z, Yi Y, Du W Abstract Red lesions can be regarded as one of the earliest lesions in diabetic retinopathy (DR) and automatic detection of red lesions plays a critical role in diabetic retinopathy diagnosis. In this paper, a novel superpixel Multichannel Multifeature (MCMF) classification approach is proposed for red lesion detection. In this paper, firstly, a new candidate extraction method based on superpixel is proposed. Then, these candidates are characterized by multichannel features, as well as the contextual feature. Next, FDA classifier is introduced to classify the red le...
Source: Computational and Mathematical Methods in Medicine - May 19, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Machine Learning Applications in Medical Image Analysis.
Authors: El-Baz A, Gimel'farb G, Suzuki K PMID: 28487745 [PubMed - in process] (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - May 12, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research