Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation
In this study, we found that GH01 effectively ameliorated dextran sulfate sodium (DSS)-induced colitis symptoms in mice. Disruption of intestinal barrier function, commensal microbiota and its metabolites were also significantly restored by GH01 in a dose-dependent manner. Of note, we also found that GH01 enhanced phagocytic ability of macrophages and switched macrophage phenotype from M1 to M2 both in vitro and in vivo. Such macrophage polarization was highly associated with intestinal barrier integrity and the gut microbial community. Consequently, GH01 exhibited strong anti-inflammatory capacity by inhibiting TLR4 and N...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 3, 2023 Category: Drugs & Pharmacology Authors: Cui Zhang Zheng Cao Hehua Lei Chuan Chen Ruichen Du Yuchen Song Ce Zhang Jinlin Zhou Yujing Lu Luodong Huang Peihong Shen Limin Zhang Source Type: research
Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation
In this study, we found that GH01 effectively ameliorated dextran sulfate sodium (DSS)-induced colitis symptoms in mice. Disruption of intestinal barrier function, commensal microbiota and its metabolites were also significantly restored by GH01 in a dose-dependent manner. Of note, we also found that GH01 enhanced phagocytic ability of macrophages and switched macrophage phenotype from M1 to M2 both in vitro and in vivo. Such macrophage polarization was highly associated with intestinal barrier integrity and the gut microbial community. Consequently, GH01 exhibited strong anti-inflammatory capacity by inhibiting TLR4 and N...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 3, 2023 Category: Drugs & Pharmacology Authors: Cui Zhang Zheng Cao Hehua Lei Chuan Chen Ruichen Du Yuchen Song Ce Zhang Jinlin Zhou Yujing Lu Luodong Huang Peihong Shen Limin Zhang Source Type: research
Molecules, Vol. 28, Pages 5837: Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells
Yonghong Liao
Myelin repair, which is known as remyelination, is critical to the treatment of neurodegenerative diseases, and myelination depends on not only the differentiation of oligodendrocyte precursor cells toward oligodendrocytes but also the renewal of oligodendrocyte precursor cells under pathological conditions. However, simultaneously promoting the differentiation and proliferation of oligodendrocyte precursor cells in lesions remains an unmet challenge and might affect demyelinating diseases. Kidney-tonifying herbs of traditional Chinese medicine (TCM) are effective in improving the symptoms of degenerative...
Source: Molecules - August 3, 2023 Category: Chemistry Authors: Feifei Yang Han Wen Siqi Ma Qi Chang Ruile Pan Xinmin Liu Yonghong Liao Tags: Article Source Type: research
Effects of genus Epimedium in the treatment of osteoarthritis and relevant signaling pathways
Osteoarthritis (OA) is a common chronic degenerative joint disease in clinical practice with a high prevalence, especially in the elderly. Traditional Chinese Medicine (TCM) believes that OA belongs to the cat... (Source: Chinese Medicine)
Source: Chinese Medicine - July 31, 2023 Category: Complementary Medicine Authors: Xue Tong, Yan Wang, Benchao Dong, Yan Li, Shuang Lang, Jianxiong Ma and Xinlong Ma Tags: Review Source Type: research
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1
CONCLUSION: ICA promoted the proliferation and osteogenic differentiation of impaired BMSCs by upregulating GLI-1.PMID:37454090 | PMC:PMC10349431 | DOI:10.1186/s13018-023-03998-w (Source: Cell Research)
Source: Cell Research - July 15, 2023 Category: Cytology Authors: Sheng-Li Xia Zi-Yuan Ma Bin Wang Feng Gao Sheng-Yang Guo Xu-Han Chen Source Type: research
The pharmacological effects and safety of the raw and prepared folium of Epimedium brevicornu Maxim. on improving kidney-yang deficiency syndrome and sexual dysfunction
Conclusion: We demonstrated that PFEB was better than RFEB at tonifying the kidney-Yang by comparing their effects on improving the NEI network, which includes the HPA axis, immune system and corpus cavernosum. This study revealed that PFEB could significantly improve the sexual function of KDS mice by regulating the HPA axis and activating the immune system through the NEI network. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 14, 2023 Category: Drugs & Pharmacology Source Type: research
A novel small molecule effectively ameliorates estrogen deficiency-induced osteoporosis by targeting the gut-bone signaling axis
Eur J Pharmacol. 2023 Jun 25:175868. doi: 10.1016/j.ejphar.2023.175868. Online ahead of print.ABSTRACTPostmenopausal osteoporosis stems mainly from estrogen deficiency leading to a gut microbiome-dependent disruption of host systemic immunity. However, the underlying mechanisms of estrogen deficiency-induced bone loss remain elusive and novel pharmaceutical intervention strategies for osteoporosis are needed. Here we reveal that ovariectomy (ovx)-induced estrogen deficiency in C57BL/6 mice causes significant disruption of gut microbiota composition, consequently leading to marked destruction of intestinal barrier function ...
Source: European Journal of Pharmacology - June 27, 2023 Category: Drugs & Pharmacology Authors: Chuan Chen Hehua Lei Yitao Zhao Yu Hou Hui Zheng Ce Zhang Zheng Cao Fang Wu Gui Chen Yuchen Song Cui Zhang Jinlin Zhou Yujing Lu Denghui Xie Limin Zhang Source Type: research
A novel small molecule effectively ameliorates estrogen deficiency-induced osteoporosis by targeting the gut-bone signaling axis
Eur J Pharmacol. 2023 Jun 25:175868. doi: 10.1016/j.ejphar.2023.175868. Online ahead of print.ABSTRACTPostmenopausal osteoporosis stems mainly from estrogen deficiency leading to a gut microbiome-dependent disruption of host systemic immunity. However, the underlying mechanisms of estrogen deficiency-induced bone loss remain elusive and novel pharmaceutical intervention strategies for osteoporosis are needed. Here we reveal that ovariectomy (ovx)-induced estrogen deficiency in C57BL/6 mice causes significant disruption of gut microbiota composition, consequently leading to marked destruction of intestinal barrier function ...
Source: European Journal of Pharmacology - June 27, 2023 Category: Drugs & Pharmacology Authors: Chuan Chen Hehua Lei Yitao Zhao Yu Hou Hui Zheng Ce Zhang Zheng Cao Fang Wu Gui Chen Yuchen Song Cui Zhang Jinlin Zhou Yujing Lu Denghui Xie Limin Zhang Source Type: research
Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in xo-LDL-induced vascular endothelial cell injury and atherosclerotic mice
Phytother Res. 2023 Jun 21. doi: 10.1002/ptr.7854. Online ahead of print.ABSTRACTVascular endothelial cells (VECs) are located between the blood plasma and the vascular tissue, and the ferroptosis (iron-dependent programmed cell death) of VECs can lead to a range of cardiovascular diseases. Icariin is the main active ingredient of Epimedium brevicornum Maxim., which can improve endothelial cell dysfunction. In the present study, the protective effects of icariin on oxidised low-density lipoprotein (ox-LDL)-treated VECs and high-fat diet-fed Apolipoprotein E-deficient mice were investigated. Inflammatory fibrosis in tissues...
Source: Atherosclerosis - June 22, 2023 Category: Cardiology Authors: Xindong Wang Meng Zhang Chenhan Mao Chengbo Zhang Wenqi Ma Jiahui Tang Dongyang Xiang Xiaoxia Qi Source Type: research
Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in xo-LDL-induced vascular endothelial cell injury and atherosclerotic mice
Phytother Res. 2023 Jun 21. doi: 10.1002/ptr.7854. Online ahead of print.ABSTRACTVascular endothelial cells (VECs) are located between the blood plasma and the vascular tissue, and the ferroptosis (iron-dependent programmed cell death) of VECs can lead to a range of cardiovascular diseases. Icariin is the main active ingredient of Epimedium brevicornum Maxim., which can improve endothelial cell dysfunction. In the present study, the protective effects of icariin on oxidised low-density lipoprotein (ox-LDL)-treated VECs and high-fat diet-fed Apolipoprotein E-deficient mice were investigated. Inflammatory fibrosis in tissues...
Source: Atherosclerosis - June 22, 2023 Category: Cardiology Authors: Xindong Wang Meng Zhang Chenhan Mao Chengbo Zhang Wenqi Ma Jiahui Tang Dongyang Xiang Xiaoxia Qi Source Type: research
Epimedium sagittatum Maxim ameliorates adriamycin ‐induced nephropathy by restraining inflammation and apoptosis via the PI3K/AKT signaling pathway
ConclusionThis study suggested that EPI ameliorates adriamycin-induced nephropathy by reducing inflammation and apoptosis through the PI3K/AKT signaling pathway, icariin may be the pharmacodynamic substance basis for this effect. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 14, 2023 Category: Allergy & Immunology Authors: Ru Wang,
Mengnan Zeng,
Beibei Zhang,
Qinqin Zhang,
Shuangshuang Xie,
Yingbo Hu,
Ruyi Fan,
Mengya Wang,
Xiao Yu,
Yuhan Zhang,
Xiaoke Zheng,
Weisheng Feng Tags: ORIGINAL ARTICLE Source Type: research
Construction of the first high-density genetic linkage map and QTL mapping of flavonoid and leaf-size related traits in Epimedium
Leaves are the main medicinal organ in Epimedium herbs, and leaf flavonoid content is an important criterion of Epimedium herbs. However, the underlying genes that regulate leaf size and flavonoid content are unc... (Source: BMC Plant Biology)
Source: BMC Plant Biology - May 25, 2023 Category: Biology Authors: Dongyue Yu, Ruoqi Huang, Shuxia Yu, Qiong Liang, Ying Wang, Haishan Dang and Yanjun Zhang Tags: Research Source Type: research
Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology
Icariin (ICA), an active ingredient extracted from Epimedium species, has shown promising results in the treatment of Alzheimer's disease (AD), although its potential therapeutic mechanism remains largely unknown... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 24, 2023 Category: Research Authors: Yuqing Liu, Hongli Li, Xiaowei Wang, Jianhua Huang, Di Zhao, Yejun Tan, Zheyu Zhang, Zhen Zhang, Lemei Zhu, Beibei Wu, Zhibao Chen and Weijun Peng Tags: Research Source Type: research
A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
A new flavonoid from < em > Epimedium brevicornu < /em > Maxim
In conclusion, we isolated and purified compound 1 (15.4 mg) and determined its chemical structure.PMID:37029621 | DOI:10.1080/14786419.2023.2199213 (Source: Natural Product Research)
Source: Natural Product Research - April 8, 2023 Category: Biochemistry Authors: Juan Jiang Bao-Guo Jiang Bing Liu Source Type: research
