Discovery of a novel small molecule with efficacy in protecting against inflammation in vitro and in vivo by enhancing macrophages activation

In this study, we found that GH01 effectively ameliorated dextran sulfate sodium (DSS)-induced colitis symptoms in mice. Disruption of intestinal barrier function, commensal microbiota and its metabolites were also significantly restored by GH01 in a dose-dependent manner. Of note, we also found that GH01 enhanced phagocytic ability of macrophages and switched macrophage phenotype from M1 to M2 both in vitro and in vivo. Such macrophage polarization was highly associated with intestinal barrier integrity and the gut microbial community. Consequently, GH01 exhibited strong anti-inflammatory capacity by inhibiting TLR4 and NF-κB pathways and proinflammatory factors (IL-6). These findings suggested that GH01 might be a potential nutritional intervention strategy for IBD treatment with the gut microbial community-meditated macrophage as the therapeutic targets.PMID:37536035 | DOI:10.1016/j.biopha.2023.115273

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 3, 2023 Category: Drugs & Pharmacology Authors: Cui Zhang Zheng Cao Hehua Lei Chuan Chen Ruichen Du Yuchen Song Ce Zhang Jinlin Zhou Yujing Lu Luodong Huang Peihong Shen Limin Zhang Source Type: research