Adult allergic rhinitis sufferers have unique nasal mucosal and peripheral blood immune gene expression profiles: A case –control study
A series of genes were differentially expressed in both peripheral blood and nasal mucosal samples from adults with moderate-severe persistent allergic rhinitis compared with adults without a history of allergic rhinitis. AbstractBackgroundAllergic rhinitis (AR) is a complex disease involving both mucosal and systemic immune compartments. Greater understanding of the immune networks underpinning AR pathophysiology may assist with further refining disease-specific biomarkers.ObjectiveTo compare immune gene expression profiles in nasal mucosa and peripheral blood samples between adults with AR and controls without AR.Methods...
Source: Immunity, Inflammation and Disease - October 13, 2021 Category: Allergy & Immunology Authors: Annabelle M. Watts, Nicholas P. West, Peter K. Smith, Allan W. Cripps, Amanda J. Cox Tags: ORIGINAL ARTICLE Source Type: research

Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans
ConclusionsTreatment strategies based on current research on the HLA gene and MERS-CoV will provide potential therapeutic targets. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 12, 2021 Category: Allergy & Immunology Authors: In ‐Cheol Baek, Eun‐Jeong Choi, Dong‐Hwan Shin, Hyoung‐Jae Kim, Haeyoun Choi, Hyoung‐Shik Shin, Dong‐Gyun Lim, Tai‐Gyu Kim Tags: SHORT REPORT Source Type: research

Immunomodulation of endothelial cells induced by macrolide therapy in a model of septic stimulation
ConclusionThis study reports phenotypic and gene expression changes in septic-stimulated ECs exposed to macrolides, without resulting in altered immunogenicity of ECs in co-cultures with PBMCs. In vivo studies may help to further understand the impact of macrolide therapy on ECs immune homeostasis during sepsis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 12, 2021 Category: Allergy & Immunology Authors: St éphanie Pons, Eden Arrii, Marine Arnaud, Maud Loiselle, Juliette Ferry, Manel Nouacer, Julien Lion, Shannon Cohen, Nuala Mooney, Lara Zafrani Tags: ORIGINAL ARTICLE Source Type: research

Omalizumab effectiveness in patients with a previously failed oral immunotherapy for severe milk allergy
ConclusionIn this series, OML was effective in patients with severe CM allergy who had previously failed OIT, allowing milk intake without adverse reactions and improving the QoL. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 8, 2021 Category: Allergy & Immunology Authors: Laura Badina, Beatrice Belluzzi, Sarah Contorno, Benedetta Bossini, Elisa Benelli, Egidio Barbi, Irene Berti Tags: SHORT REPORT Source Type: research

Imiquimod induced vitiligo ‐like lesions—A consequence of modified melanocyte function
ConclusionsThis study shows that imiquimod directly inhibits melanogenesis and increases melanocyte apoptosis rates. These effects combined with the upregulation of TLR7 and TLR9 together with increased autophagy activity and inflammatory cytokines production, might be the main reasons leading to hypopigmented lesions after imiquimod application. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 7, 2021 Category: Allergy & Immunology Authors: Haiyan Yu, Jianping Cen, Xiaoxia Lin, Hao Cheng, Oliver Seifert Tags: ORIGINAL ARTICLE Source Type: research

The syndemic burden of HIV/AIDS in Africa amidst the COVID ‐19 pandemic
Conclusions: Before efforts are made to improve the provision of HIV/AIDS and COVID-19 care within Africa, it is important that this issue is brought to the attention of the scientific and clinical community so that the continent can receive the necessary support and aid. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 5, 2021 Category: Allergy & Immunology Authors: Olivier Uwishema, Charles Taylor, Lukman Lawal, Nakyanzi Hamiidah, Isoke Robert, Abdulrasheed Nasir, Elie Chalhoub, Jeffrey Sun, Burak T. Akin, Irem Adanur, Rehema M. Mwazighe, Helen Onyeaka Tags: COMMENTARY Source Type: research

Multidirectional facets of obesity management in the metabolic syndrome population after liver transplantation
The obesity pandemic has resulted in an increasing demand for liver transplantation and has significantly altered the profile of liver transplant candidates in addition to affecting posttransplantation outcomes. Metabolic syndrome following liver transplant is a common phenomenon and is implicated as an important contributor to decades-long unimproved long-term outcomes after organ transplant procedure. In this review, we discuss a broad range of clinical approaches that warrant attention to provide comprehensive and patient-centred medical care to liver transplant recipients, and to be prepared to confront the rapidly cha...
Source: Immunity, Inflammation and Disease - October 2, 2021 Category: Allergy & Immunology Authors: Kinga Czarnecka, Paulina Czarnecka, Olga Tronina, Teresa B ączkowska, Magdalena Durlik Tags: REVIEW ARTICLE Source Type: research

Immunogenomic characterization in gastric cancer identifies microenvironmental and immunotherapeutically relevant gene signatures
ConclusionsThis study demonstrated the immunogenomic characterizations could play a crucial role in shaping the complexity and diversity of tumor microenvironment. Targeting tumor immunogenomic characteristic in order for changing adverse phenotypes may contribute to exploiting the novel immunotherapy combination strategies or novel immunotherapeutic drugs, and promoting the advance of tumor personalized immunotherapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 30, 2021 Category: Allergy & Immunology Authors: Xiao Han, Heyue Lu, Xiaojun Tang, Yao Zhao, Hongxue Liu Tags: ORIGINAL ARTICLE Source Type: research

Characterising the allergic profile of children with cystic fibrosis
Graphical abstract“Example allergic timelines for children with CF” AbstractBackgroundCystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised problem but other allergic conditions are less well documented in CF.ObjectiveTo characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA.MethodsA cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features.ResultsThe cohort included 37 children w...
Source: Immunity, Inflammation and Disease - September 27, 2021 Category: Allergy & Immunology Authors: Amy L. Faulkner, Michael Grayling, Benjamin Shillitoe, Malcolm Brodlie, Louise J. Michaelis Tags: ORIGINAL ARTICLE Source Type: research

Interleukin ‐6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model
ConclusionsThis study reveals intratumoral Th17 subpopulations with distinct functional properties and signaling patterns, thus offering valuable insight into Th17 heterogeneity and plasticity in lung cancer. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 27, 2021 Category: Allergy & Immunology Authors: Chong Liu, Fei Xiong, Lingying Wang, Kang Chen, Pingshang Wu, Li Hua, Zhuo Zhang Tags: ORIGINAL ARTICLE Source Type: research

A single ‐center, open‐label, randomized cross‐over study to evaluate the pharmacokinetics and bioavailability of once‐daily prolonged‐release formulations of tacrolimus in de novo liver transplant recipients
ConclusionDespite methodological weaknesses that limit the conclusions, we have found a more consistent drug exposure for LCP-Tac in de novo LT recipients. LCP-Tac demonstrated a greater bioavailability compared to PR-Tac. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 24, 2021 Category: Allergy & Immunology Authors: Uta Herden, Martina Sterneck, Bettina M. Buchholz, Eike G. Achilles, Armin Ott, Lutz Fischer Tags: ORIGINAL ARTICLE Source Type: research

Difference in the plasma level of miR ‐628‐3p in atopic dermatitis patients with/without atopic keratoconjunctivitis
ConclusionOur new findings suggest that the plasma miR-628-3p level may represent a marker to predict the presence of severe AKC in AD patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 22, 2021 Category: Allergy & Immunology Authors: Mayumi Ueta, Hiromi Nishigaki, Seitaro Komai, Chie Sotozono, Shigeru Kinoshita Tags: SHORT REPORT Source Type: research

Airway cilia recovery post lung transplantation
Reduced airway cilia function is evident in the first 12 weeks post lung transplant, with both CBP and CBF returning to levels of function indistinguishable to the patients' upper airway cilia beyond this time. This difference may be a cause for increased risk of airway infection during this period. AbstractBackgroundNormally functioning airway cilia is essential for efficient mucociliary clearance to protect the airway from various insults. Impaired clearance may lead to increased risk of infections and progressive lung damage. Significant morbidity in the immediate post lung transplantation period is associated with airw...
Source: Immunity, Inflammation and Disease - September 21, 2021 Category: Allergy & Immunology Authors: Randy Suryadinata, Kovi Levin, Lynda Holsworth, Miranda Paraskeva, Philip Robinson Tags: ORIGINAL ARTICLE Source Type: research

LncRNA CAIF suppresses LPS ‐induced inflammation and apoptosis of cardiomyocytes through regulating miR‐16 demethylation
ConclusionOur study is the first to report the abnormal expression of CAIF and miR-16 in heart disease. CAIF plays a protective role in sepsis-induced CHF by inhibiting cardiomyocyte apoptosis and inflammation, possibly by regulating miR-16 demethylation. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 21, 2021 Category: Allergy & Immunology Authors: Yan Wang, Yi Zhang Tags: ORIGINAL ARTICLE Source Type: research

The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta ‐analysis
This study investigated the relationship between serum calcium and clinical outcomes in patients with COVID-19.MethodThis study is a systematic review and meta-analysis by searching PubMed, Scopus, web of sciences until August 2021 using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID, coronavirus disease, SARS-COV-infection. 2, SARS-COV-2, COVID19, calcium, calcium isotopes, calcium radioisotopes, hypercalcemia, and hypocalcemia were performed. Heterogeneity of studies was investigated usingI2 index, data were analyzed using meta-analysis (random effects model) with Comprehensive...
Source: Immunity, Inflammation and Disease - September 18, 2021 Category: Allergy & Immunology Authors: Effat Alemzadeh, Esmat Alemzadeh, Masood Ziaee, Ali Abedi, Hamid Salehiniya Tags: REVIEW ARTICLE Source Type: research

Development and characterization of a unique anti ‐IgE mouse monoclonal antibody cross‐reactive between human and canine IgE
Conclusions and Clinical RelevanceCRE-DR is a mAb cross-reactive to dog and human IgEs, which can allow the use of a dog model of allergy to test the efficacy of a CRE-DR-derived anti-IgE therapeutic mAb before human clinical trials. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 17, 2021 Category: Allergy & Immunology Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda Tags: ORIGINAL ARTICLE Source Type: research

Cancer ‐testis antigen ACRBP expression and serum immunoreactivity in ovarian cancer: Its association with prognosis
ConclusionACRBP expression was upregulated in OC tissues and induced humoral immune response in patients with OC, suggesting that ACRBP is a potential prognostic biomarker and a target of tumor immunotherapy for OC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 16, 2021 Category: Allergy & Immunology Authors: Lina Lin, Weixia Nong, Bin Luo, Yingying Ge, Xia Zeng, Feng Li, Rong Fan, Qingmei Zhang, Xiaoxun Xie Tags: ORIGINAL ARTICLE Source Type: research

A single dose of the Biontech/Pfizer BNT162b2 vaccine protected elderly residents from severe COVID ‐19 during a SARS‐coronavirus‐2 outbreak in a senior citizen home in Germany
Conclusions: In summary, our data show that partial vaccination prevented severe COVID-19 among the residents during this local SARS-CoV-2 outbreak, suggesting a high effectiveness of even a single vaccine dose, but also emphasize that asymptomatic individuals might still be carriers/spreaders. AbstractBackground: A total of 62/66 (93.9%) residents in a senior citizen home in Bremen, Germany, received the first dose of the Biontech/Pfizer vaccine BNT162b2 on December 27th 2020. After routine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests showed positive results on January 5th, all residents and ...
Source: Immunity, Inflammation and Disease - September 16, 2021 Category: Allergy & Immunology Authors: Rolf Schwarzer, Sabine D. Freys, Nick Neuwinger, Nina Beikert, Bettina Ebersp ächer, Anke Edelmann, Marta Zuchowski, Inga Slothouwer, Angela Stein, Kathrin Theil, Peter Menzel, Jörg Hofmann Tags: SHORT REPORT Source Type: research

Soluble CD127 potentiates IL ‐7 activity in vivo in healthy mice
ConclusionsThese findings suggest that the addition of sCD127 enhances IL-7-mediated T-cell proliferation and suggests a potential therapeutic use for sCD127. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 16, 2021 Category: Allergy & Immunology Authors: Nawaf A. Aloufi, Alaa K. Ali, Stephanie C. Burke Schinkel, Bengisu Molyer, Priscila O. Barros, Joanne E. McBane, Seung ‐Hwan Lee, Jonathan B. Angel Tags: SHORT REPORT Source Type: research

Cytomegalovirus mismatch after heart transplantation: Impact of antiviral prophylaxis and intravenous hyperimmune globulin
Seropositive recipients carry an important risk for CMV-DNAemia. However, we did not observe differences in perioperative morbidity and mortality regarding CMV matching, which might be related to regularly administer prophylactic virostatics and additional CMV-IVIG for risk constellations. For high-risk constellation, long-term application of CMV-IVIG during the first year after transplant may be beneficial. AbstractObjectiveCytomegalovirus (CMV) infections are correlated with complications following heart transplantation (HTx) and impaired outcome. The impact of a serologic mismatch between donor and recipient and the nec...
Source: Immunity, Inflammation and Disease - September 15, 2021 Category: Allergy & Immunology Authors: Moritz B. Immohr, Payam Akhyari, Charlotte B öttger, Arash Mehdiani, Hannan Dalyanoglu, Ralf Westenfeld, Daniel Oehler, Igor Tudorache, Hug Aubin, Artur Lichtenberg, Udo Boeken Tags: ORIGINAL ARTICLE Source Type: research

CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid ‐derived suppressor cells
ConclusionsOur study indicates that PDAC cells produced CCL2, which promoted localized M-MDSC recruitment and immune suppression, thereby promoting tumor progression. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 15, 2021 Category: Allergy & Immunology Authors: Haitao Gu, Wensheng Deng, Zhong Zheng, Ke Wu, Feng Sun Tags: ORIGINAL ARTICLE Source Type: research

Proteomic profiling of saliva reveals association of complement system with primary Sj ögren's syndrome
ConclusionsThe salivary proteome of ESS mice was markedly different from that of healthy controls, suggesting that salivary proteomics is a promising noninvasive diagnostic tool for pSS. SERPING1, C3, CFH, FGA, and FGG are potential biomarkers of pSS. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 13, 2021 Category: Allergy & Immunology Authors: Mingde Li, Yajun Qi, Guizhen Wang, Su Bu, Ming Chen, Jiahui Yu, Tianyang Luo, Lulu Meng, Anran Dai, Yong Zhou, Shuai Liu, Xingxing Huo Tags: ORIGINAL ARTICLE Source Type: research

Predominant frequency of HLA ‐B*27 in patients with ankylosing spondylitis in southeastern China
ConclusionsOur study shows that HLA-B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA-B*27-subtype distributions in Chinese Han populations showed that HLA-B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA-B*2705 show the opposite result. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 10, 2021 Category: Allergy & Immunology Authors: JiaoJiao Lu, Jing Yang, WenXu Dong, BaoJia Tang, LuoYuan Cao, YingHua Lin, BaoYing Huang, XianGuo Fu Tags: ORIGINAL ARTICLE Source Type: research

NOD/scid IL ‐2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype
ConclusionThe NSG-CD model partially reflects the human disease and allows for studying the development of fibrosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 9, 2021 Category: Allergy & Immunology Authors: Anna ‐Lena Unterweger, Alena Rüscher, Marietta Seuß, Paula Winkelmann, Florian Beigel, Leandra Koletzko, Simone Breiteneicher, Matthias Siebeck, Roswitha Gropp, Attila Aszodi Tags: ORIGINAL ARTICLE Source Type: research

TIM ‐3 as a potential exhaustion marker in CD4+ T cells of COVID‐19 patients
In this study, we evaluated 44 patients with confirmed COVID-19 disease and 16 healthy individuals. Patients were divided into moderate/severe and critical groups. Peripheral blood mononuclear cells (PBMCs) were isolated and stained by anti-human CD39, PD-1, TIM-3, and anti-human CD4. The percentage of each CD4+ subpopulation was calculated by flow cytometry. Furthermore, we collected clinical information and laboratory data of both control and patient groups.ResultsWe detected overexpression of TIM-3 on CD4+ T cells in both critical and moderate/severe patients than in healthy individuals (HIs; p 
Source: Immunity, Inflammation and Disease - September 9, 2021 Category: Allergy & Immunology Authors: Zahra Modabber, Mehdi Shahbazi, Roghayeh Akbari, Mojgan Bagherzadeh, Alireza Firouzjahi, Mousa Mohammadnia ‐Afrouzi Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term effects of obesity on COVID‐19 patients discharged from hospital
ConclusionIn the long term, obesity affects clinical manifestations, immune function and endocrine metabolism in patients discharged after recovering from COVID-19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 9, 2021 Category: Allergy & Immunology Authors: Luorui Shang, Li Wang, Fangyuan Zhou, Jinxiao Li, Yuhan Liu, Shenglan Yang Tags: ORIGINAL ARTICLE Source Type: research

SARS ‐CoV‐2 infection shortly after BNT162b2 vaccination results in high anti‐spike antibody levels in nursing home residents and staff
ConclusionsOur data show that individuals who got infected as early as 10 days after their first immunization show antibody levels comparable to fully vaccinated individuals. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 9, 2021 Category: Allergy & Immunology Authors: Doris Urlaub, Natalie Wolfsdorff, Deniz Durak, Frank Renken, Carsten Watzl Tags: ORIGINAL ARTICLE Source Type: research

Study on the contrast of the MHC –peptide interaction of B2/B21 haplotype and MHC‐related virus resistance in chickens
Conclusion of this study: There are usually various kinds of peptides presented by the BF21*2101 molecules of B21 haplotypes, resulting in resistance to pathogenic microorganisms, such as Rous sarcoma virus (RSV) and/or Marek's disease virus (MDV). AbstractIntroductionThree-dimensional (3D) structures of MHC class I exert some influence by the MHC –peptide interaction over host resistance to the virus. The thesis aims at studying the connection between MHC–peptide interaction of B2/B21 haplotype and MHC-related resistance to the virus.MethodsThe structure of chicken MHC class I BF2*0201 from B2 haplotype was st...
Source: Immunity, Inflammation and Disease - September 3, 2021 Category: Allergy & Immunology Authors: Yuan ‐chang Jin, Wei Wang, Min‐min Yu, Mei‐lin Hao, Gang Zeng, Jing‐fen Chen, Juan Dai, Yu‐jie Wu Tags: ORIGINAL ARTICLE Source Type: research

Extra ‐articular involvement of rheumatoid arthritis in three seropositive patients in the absence of initial joint involvement
ConclusionEAI as an onset of RA is a complex and not easily recognized entity if typical joints involvement is not yet present. Early diagnosis may help guide specific therapy and prevent sequelae and co-morbidities. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 2, 2021 Category: Allergy & Immunology Authors: Razvan M. Chirila, Florentina Berianu, Andy Abril, Ronald R. Butendieck Tags: ORIGINAL ARTICLE Source Type: research

The future of tumor vaccines in the post ‐COVID‐19 era—Current challenges
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 2, 2021 Category: Allergy & Immunology Authors: Panagiotis F. Christopoulos Tags: SHORT REPORT Source Type: research

Role of neutrophils in acute viral infection
AbstractNeutrophils play multiple roles in acute viral infections. They restrict viral replication and diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and the release of neutrophil extracellular traps, as well as, activate the adaptive immune response. However, the overactivation of neutrophils may cause tissue damage and lead to poor outcomes. Additionally, some characteristics and functions of neutrophils, such as cell number, lifespan, and antiviral capability, can be influenced while eliminating viruses. This review provides a general description of the protective and pathologi...
Source: Immunity, Inflammation and Disease - September 2, 2021 Category: Allergy & Immunology Authors: Yuan Ma, Yue Zhang, Liuluan Zhu Tags: REVIEW ARTICLE Source Type: research

First lung transplant in Wuhan for a critical and elderly COVID ‐19 patient
ConclusionsWe suggest that a lung transplantation may be a viable treatment for patients with end-stage pulmonary failure secondary to COVID-19 in selected situations. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 1, 2021 Category: Allergy & Immunology Authors: Bo Wang, Jie Huang, Micheal Hsin, Jingyu Chen, Huiqing Lin Tags: ORIGINAL ARTICLE Source Type: research

Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease
ConclusionsThis study is the first to build a gene expression prediction model for UST response in patients with CD and provides valuable data sources for further studies. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - September 1, 2021 Category: Allergy & Immunology Authors: Manrong He, Chao Li, Wanxin Tang, Yingxi Kang, Yongdi Zuo, Yufang Wang Tags: ORIGINAL ARTICLE Source Type: research

Highly expressed of SERPINA3 indicated poor prognosis and involved in immune suppression in glioma
ConclusionsSERPINA3 may play a key role in the biological process of glioma cells especially in immune suppression activities. SERPINA3 may serve as an independent survival prediction factor in glioma patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 28, 2021 Category: Allergy & Immunology Authors: Qing Yuan, Song ‐Quan Wang, Guang‐Tao Zhang, Jie He, Zhi‐Dan Liu, Ming‐Rong Wang, Hong‐Qing Cai, Jing‐Hai Wan Tags: ORIGINAL ARTICLE Source Type: research

microRNAs in human brucellosis: A promising therapeutic approach and biomarker for diagnosis and treatment
ConclusionsThe interplay between miRNAs andBrucella pathogens and the underlying process required comprehensive examination to unravel the novel therapeutic or diagnostic approaches. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 27, 2021 Category: Allergy & Immunology Authors: Sima Kazemi, Rasoul Mirzaei, Mohammad Sholeh, Sajad Karampoor, Fariba Keramat, Massoud Saidijam, Mohammad Yousef Alikhani Tags: REVIEW ARTICLE Source Type: research

Ferritin level: A predictor of severity and mortality in hospitalized COVID ‐19 patients
This study aims to investigate in-h оsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.MethodsPatients were stratified based on ferritin levels (ferritin levels  ≤ 1000 or>1000).ResultsApproximately 89% (118) of the patients with ferritin levels  >  1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36...
Source: Immunity, Inflammation and Disease - August 27, 2021 Category: Allergy & Immunology Authors: Moudhi Alroomi, Rajesh Rajan, Abdulaziz A. Omar, Ahmad Alsaber, Jiazhu Pan, Mina Fatemi, Kobalava D. Zhanna, Wael Aboelhassan, Farah Almutairi, Naser Alotaibi, Mohammad A. Saleh, Noor AlNasrallah, Bader Al ‐Bader, Haya Malhas, Maryam Ramad Tags: ORIGINAL ARTICLE Source Type: research

Integrated analysis on the N6 ‐methyladenosine‐related long noncoding RNAs prognostic signature, immune checkpoints, and immune cell infiltration in clear cell renal cell carcinoma
ConclusionsThe seven m6A-related lncRNAs prognostic risk signature showed reliable prognostic predictive power for ccRCC and was associated with the expression of immune checkpoints and immune cell infiltration. This seven m6A-related lncRNAs signature will be helpful in managing ccRCC and guiding individualized immunotherapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 26, 2021 Category: Allergy & Immunology Authors: Yuqin Qiu, Xiaogang Wang, Zhenjia Fan, Shanhui Zhan, Xin Jiang, Jinchang Huang Tags: ORIGINAL ARTICLE Source Type: research

Programmed death ‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade
ConclusionsThese findings suggest that the PD-1/PD-L1 pathway could be also involved in immunosuppression in chronic infections in pigs. This study provides a new perspective on therapeutic strategies for chronic diseases in pigs by targeting immunosuppressive pathways. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 21, 2021 Category: Allergy & Immunology Authors: Otgontuya Ganbaatar, Satoru Konnai, Tomohiro Okagawa, Yutaro Nojima, Naoya Maekawa, Yoshiki Ichikawa, Atsushi Kobayashi, Tomoyuki Shibahara, Yojiro Yanagawa, Hidetoshi Higuchi, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi Tags: ORIGINAL ARTICLE Source Type: research

Follow ‐up of renal transplant recipients after acute COVID‐19—A prospective cohort single‐center study
ConclusionPost-COVID-19 clinical and laboratory complications are frequent in the renal transplant population, in some of them associated with significant morbidity. All patients recovered from acute COVID-19 should undergo long-term monitoring for evaluation and treatment of complications. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 20, 2021 Category: Allergy & Immunology Authors: Nikolina Basic ‐Jukic, Ivana Juric, Vesna Furic‐Cunko, Lea Katalinic, Josipa Radic, Zrinka Bosnjak, Bojan Jelakovic, Zeljko Kastelan Tags: ORIGINAL ARTICLE Source Type: research

Impaired T helper cell responses in human immunodeficiency virus ‐exposed uninfected newborns
ConclusionHEU neonates are born with reduced proportions of differentiated Th1/Th2/Th17 and CD4+CD25++ T cells, but the intrinsic abilities of CD4+ T cells to acquire a Th1 profile are not affected by the adverse maternal milieu during development. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 19, 2021 Category: Allergy & Immunology Authors: Yesenia Brito ‐Pérez, Rodrigo T. Camacho‐Pacheco, Noemi Plazola‐Camacho, Diana Soriano‐Becerril, Irma A. Coronado‐Zarco, Gabriela Arreola‐Ramírez, Gabriela González‐Pérez, Alma Herrera‐Salazar, Julio Flores‐González, Mextli Tags: ORIGINAL ARTICLE Source Type: research

Donor ‐derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation
ConclusionsWe showed the protective effects of donor-derived M2 macrophages on GVHD and improved survival in a model of HSCT. Our data suggest that donor-derived M2 macrophages offer the potential for cell-based therapy to treat GVHD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 19, 2021 Category: Allergy & Immunology Authors: Ryo Hanaki, Hidemi Toyoda, Shotaro Iwamoto, Mari Morimoto, Daisuke Nakato, Takahiro Ito, Kaori Niwa, Keishiro Amano, Ryotaro Hashizume, Isao Tawara, Masahiro Hirayama Tags: ORIGINAL ARTICLE Source Type: research

Impact of low ‐level pretransplant donor‐specific antibodies on outcomes after kidney transplantation
ConclusionWhile low-level DSA should not prevent proceeding with kidney transplantation, it should not be ignored. Future studies are needed to investigate the long-term effects of varying levels of pre-transplant DSA on outcomes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 18, 2021 Category: Allergy & Immunology Authors: Sandesh Parajuli, Natalie M. Bath, Luis Hidalgo, Glen Leverson, Neetika Garg, Robert R. Redfield, Didier A. Mandelbrot Tags: ORIGINAL ARTICLE Source Type: research

The study on the function and cell source of interleukin ‐6 in interstitial cystitis/bladder painful syndrome rat model
This study found that interleukin-6 plays an important role as a proinflammatory factor in the inflammatory progression of interstitial cystitis/bladder painful syndrome (IC/BPS), which is mainly derived from the synthesis and secretion of macrophages. AbstractObjectiveThe elevated expression of interleukin-6 (IL-6) in patients with interstitial cystitis/bladder painful syndrome (IC/BPS) has been demonstrated, but the role of IL-6 in IC/BPS and its source remain to be explored.MethodsIC/BPS rat model was created in female rats by using long-term intermittent intravesical hyaluronidase (0.5  ml, 4 mg/ml). Afte...
Source: Immunity, Inflammation and Disease - August 18, 2021 Category: Allergy & Immunology Authors: Zhenming Zheng, Jiapeng Zhang, Caixia Zhang, Wenshuang Li, Kaiqun Ma, Hao Huang, Kuiqing Li, Yousheng Yao Tags: ORIGINAL ARTICLE Source Type: research

Clinical observation of the efficacy of PD ‐1/PD‐L1 inhibitors in the treatment of patients with advanced solid tumors
ConclusionThe efficacy of PD-1/PD-L1 inhibitors in the treatment of advanced solid tumors was comparable to previous studies. ECOG performance status, smoking status, liver metastasis, neutrophil-to-lymphocyte ratio were independently correlated with PFS while liver metastasis and lactate dehydrogenase level were independently correlated with OS. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 18, 2021 Category: Allergy & Immunology Authors: Miao Wang, Hongchao Zhen, Xiaoyue Jiang, Yuting Lu, Yuhan Wei, Jiangtao Jin, Qin Li Tags: ORIGINAL ARTICLE Source Type: research

Cardiac biomarkers, cardiac injury, and comorbidities associated with severe illness and mortality in coronavirus disease 2019 (COVID ‐19): A systematic review and meta‐analysis
ConclusionMost of the findings clearly indicate that hypertension, cardiovascular disease, acute cardiac injury, and related laboratory indicators are associated with the severity of COVID-19. What is now needed are  cross-national prospectively designed observational or clinical trials that will help improve the certainty of the available evidence and treatment decisions for patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 18, 2021 Category: Allergy & Immunology Authors: Zhengchuan Zhu, Miaoran Wang, Wei Lin, Qiaoyan Cai, Ling Zhang, Daxin Chen, Fei Liu, Xiaoman Xiong, Jianfeng Chu, Jun Peng, Keji Chen Tags: REVIEW Source Type: research

Sustained expression of inflammatory monocytes and activated T cells in COVID ‐19 patients and recovered convalescent plasma donors
ConclusionsPatients who have recovered and considered for COPLA donations still have compromised immunity with sustained expression of inflammatory monocytes and activated T cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 7, 2021 Category: Allergy & Immunology Authors: Ravinder Singh, Hamed Hemati, Meenu Bajpai, Pushpa Yadav, Ashish Maheshwari, Suresh Kumar, Sonal Agrawal, Jayesh Kumar Sevak, Mojahidul Islam, Jaswinder Singh Mars, Shiv K Sarin, Nirupama Trehanpati Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 6, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Efficacy and safety of arbidol (umifenovir) in patients with COVID ‐19: A systematic review and meta‐analysis
ConclusionThe present meta-analysis showed no significant benefit of using arbidol compared with non-antiviral treatment or other therapeutic agents against COVID-19 disease. High-quality studies are needed to establish the efficacy and safety of arbidol for COVID-19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 4, 2021 Category: Allergy & Immunology Authors: Behnam Amani, Bahman Amani, Sara Zareei, Mahsa Zareei Tags: REVIEW ARTICLE Source Type: research

Vitamin D receptor gene polymorphisms in atopy
ConclusionsThere is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 3, 2021 Category: Allergy & Immunology Authors: Laura Tamasauskiene, Ieva Golubickaite, Rasa Ugenskiene, Nikolajs Sjakste, Natalia Paramonova, Lawrence Shih ‐Hsin Wu, Lawrence Shih‐Jiu‐Yao Wang, Brigita Sitkauskiene Tags: REVIEW ARTICLE Source Type: research

Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO ‐1 pathways
ConclusionPts alleviated oxidative stress and allergic airway inflammation via regulation of AMPK/Sirt1and Nrf2/HO-1 signaling pathways. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - August 3, 2021 Category: Allergy & Immunology Authors: Chang Xu, Yilan Song, Zhiguang Wang, Jingzhi Jiang, Yihua Piao, Li Li, Shan Jin, Liangchang Li, Lianhua Zhu, Guanghai Yan Tags: ORIGINAL ARTICLE Source Type: research