IL ‐13 modulates ∆Np63 levels causing altered expression of barrier‐ and inflammation‐related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis
ConclusionsWe have shown that ΔNp63 modulated AD‐related barrier and inflammatory molecules. In addition, ΔNp63 expression was affected by IL‐4/IL‐13. IL‐13–ΔNp63 axis would integrate two major factors of AD pathogenesis: dysregulated barrier and inflammation. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 6, 2021 Category: Allergy & Immunology Authors: Terufumi Kubo, Sayuri Sato, Tokimasa Hida, Tomoyuki Minowa, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Hisashi Uhara, Toshihiko Torigoe Tags: ORIGINAL ARTICLE Source Type: research

Immunoglobulin G: A useful outcome marker in the follow ‐up of cystic fibrosis patients?
ConclusionThe IgG profile of pediatric patients with CF has changed over recent decades, particularly with regard to hyper ‐IgG. In a significant portion of the pediatric CF population, hypo‐IgG is transient and only identifiable in longitudinal assessments. This study reinforces that hypo‐IgG patients paradoxically present a more favorable course of clinical status. Therefore, IgG levels could be a useful outcome marker in the follow‐up of patients with CF. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 30, 2021 Category: Allergy & Immunology Authors: Laurence S. Hanssens, Sarah Cellauro, Jean Duchateau, Georges J. Casimir Tags: ORIGINAL ARTICLE Source Type: research

Construction and validation of a machine learning ‐based nomogram: A tool to predict the risk of getting severe coronavirus disease 2019 (COVID‐19)
ConclusionIn this study, our predicting model based on five clinical characteristics of COVID ‐19 patients will enable clinicians to predict the potential risk of developing critical illness and thus optimize medical management. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 17, 2021 Category: Allergy & Immunology Authors: Zhixian Yao, Xinyi Zheng, Zhong Zheng, Ke Wu, Junhua Zheng Tags: ORIGINAL RESEARCH Source Type: research

Current research status of HLA in immune ‐related diseases
AbstractHuman leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas. HLA is divided into class I antigens, class II antigens, and class III antigens according to distribution and function. Classical HLA class I antigens include HLA ‐A, HLA‐B, and HLA‐C; HLA class II antigens include HLA‐DP, HLA‐DQ, and HLA‐DR; nonclassical HLA class I and II molecules include HLA‐F, E, H, X, DN, DO, and DM; and others, such as complement, are class ...
Source: Immunity, Inflammation and Disease - March 8, 2021 Category: Allergy & Immunology Authors: Bingnan Liu, Yuanyuan Shao, Rong Fu Tags: REVIEW Source Type: research

Pediatric asthma control during the COVID ‐19 pandemic
Our research showed a significant impact of the COVID ‐19 pandemic lockdown in the north‐east of Italy on asthmatic children. In particular: (1) The level of asthma control resulted improved during the lockdown period, likely because of the reduced exposure to typical asthma triggers due to the confinement; (2) The maintenance treatment resulted reduced in some patients, likely because of the good level of disease control, and increased in other patients, either because of symptoms or because of fear and anxiety related to the spreading of the COVID‐19 pandemic. AbstractBackgroundThe lockdown imposed by the...
Source: Immunity, Inflammation and Disease - March 3, 2021 Category: Allergy & Immunology Authors: Valentina Agnese Ferraro, Andrea Zamunaro, Silvia Spaggiari, Daniela Di Riso, Stefania Zanconato, Silvia Carraro Tags: ORIGINAL RESEARCH Source Type: research

A territory ‐wide study on the factors associated with recurrent asthma exacerbations requiring hospitalization in Hong Kong
Conclusions and Clinical RelevanceImproving asthma care, especially in elderly patients with a prior history of urgent healthcare utilization and comorbidities, may help reduce healthcare burden. Suboptimal management before the index admission was common in patients hospitalized for asthma exacerbations. Early identification of patients at risk and enhancement of baseline asthma management may help to prevent recurrent asthma exacerbation and subsequent hospitalization. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 3, 2021 Category: Allergy & Immunology Authors: Ka Pang Chan, Fanny Wai San Ko, Kwun Cheung Ling, Pik Shan Cheung, Lee Veronica Chan, Yu Hong Chan, Yi Tat Lo, Chun Kong Ng, Macy Mei ‐sze Lui, Kwok Sang Wilson Yee, Cee Zhung Steven Tseng, Pak Yiu Tse, Mo Lin Maureen Wong, Kah Lin Choo, W Tags: ORIGINAL RESEARCH Source Type: research

Bioinformatics analysis of the prognosis and biological significance of VCAN in gastric cancer
In conclusion, we hold the view that VCAN may affect the development of GC by regulating the TME, which may act as a potential therapeutic target for GC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 25, 2021 Category: Allergy & Immunology Authors: Xiao ‐yan Huang, Jin‐jian Liu, Xiong Liu, Yao‐hui Wang, Wei Xiang Tags: ORIGINAL RESEARCH Source Type: research

Oral birch pollen immunotherapy with apples: Results of a phase II clinical pilot study
A 70% of patients suffering from birch pollen allergy (BPA) develop a pollen ‐related food allergy (prFA), especially to apples. This is due to a strong clinically relevant homology between the major allergen in birch Bet v 1 and Mal d 1 in apples. Therefore a pilot trial using fresh apples for allergen‐specific immunotherapy to birch pollen was performed. After 8 months of therapy, patients showed increased tolerance to apples and other birch pollen‐related food allergens. Moreover, daily rhinoconjunctivitis combined symptom and medication score (CSMS) declined by 34% (p 
Source: Immunity, Inflammation and Disease - February 23, 2021 Category: Allergy & Immunology Authors: Bettina Nothegger, Norbert Reider, Claudia E. Covaciu, Valentina Cova, Linda Ahammer, Reiner Eidelpes, Jana Unterhauser, Stefan Platzgummer, Elisabeth Raffeiner, Martin Tollinger, Thomas Letschka, Klaus Eisendle Tags: ORIGINAL RESEARCH Source Type: research

Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo
In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells onCtsk deficient stromal cells display reduced colony formation and proliferation, with increased differentiation, giving rise to repopulating cells with reduced ability to repopulate the donor LSKs and T cell compartments in the bone marrow (BM). Subsequent in vivo experiments showed impairment of lymphocyte numbers, but, gross effects on early hematopoiesis or myelopoiesis were not found. Most consistently in in vivo experim...
Source: Immunity, Inflammation and Disease - February 16, 2021 Category: Allergy & Immunology Authors: Renate Hausinger, Marianne Hackl, Ana Jardon Alvarez, Miriam Kehr, Sandra Romero Marquez, Franziska Hettler, Christian Kehr, Sandra Grziwok, Christina Schreck, Christian Peschel, Rouzanna Istv ánffy, Robert A. J. Oostendorp Tags: ORIGINAL RESEARCH Source Type: research

SLy2 ‐overexpression impairs B‐cell development in the bone marrow and the IgG response towards pneumococcal conjugate‐vaccine
ConclusionOur findings demonstrate an important role of the adapter protein SLy2 in the context of adaptive antibody responses against pneumococcal conjugate ‐vaccine. Interestingly, deficits in humoral immunity seemed to be compensated by cellular immune effectors upon bacterial challenge. Our study further shows a novel relevance of SLy2 for plasmablasts and B‐cell progenitors in the BM. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 16, 2021 Category: Allergy & Immunology Authors: Jennifer Jaufmann, Leyla T ümen, Sandra Beer‐Hammer Tags: ORIGINAL RESEARCH Source Type: research

Age ‐related differences in the immune response could contribute to determine the spectrum of severity of COVID‐19
AbstractCoronavirus disease 2019 (COVID ‐19), can present with a wide spectrum of severity. Elderly patients with cardiac, pulmonary and metabolic comorbidities are more likely to develop the severe manifestations of COVID‐19, which are observed in less than 5% of the pediatric patients. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is able to induce an immune impairment and dysregulation, finally resulting in the massive release of inflammatory mediators, strongly contributing to the pulmonary and systemic manifestations in COVID‐19. In children, the immune dysregulation following SARS‐CoV‐2 c...
Source: Immunity, Inflammation and Disease - February 10, 2021 Category: Allergy & Immunology Authors: Giorgio Costagliola, Erika Spada, Rita Consolini Tags: REVIEW Source Type: research

Monitoring of hepatitis E virus RNA during treatment for chronic hepatitis E virus infection after renal transplantation
ConclusionReduction of daily dose of MPA therapy alone in transplant patients with chronic HEV infection may not be sufficient to control viral replication. HEV clearance under ribavirin therapy shows interindividual variability. Therefore, serial viral monitoring may be useful to personalize treatment duration. Rituximab therapy is a risk factor for complicated ‐to‐treat chronic HEV infection. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2021 Category: Allergy & Immunology Authors: Patrick Affeldt, Veronica Di Cristanziano, Franziska Grundmann, Maike Wirtz, Rolf Kaiser, Thomas Benzing, Dirk Stippel, Martin Kann, Christine Kurschat Tags: ORIGINAL RESEARCH Source Type: research

Active vitamin D3 attenuates the severity of Salmonella colitis in mice by orchestrating innate immunity
ConclusionsOur results document that active vitamin D3 reducedSalmonella colitis by decreasing inflammation, and bacterial translocation via induction of killing and autophagic clearance of pathogenic organisms. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2021 Category: Allergy & Immunology Authors: Fu ‐Chen Huang, Shun‐Chen Huang Tags: ORIGINAL RESEARCH Source Type: research

Detection of antigens and anti ‐Toxocara canis antibodies in children with different asthma severities
ConclusionIt is possible to detect L3TES in patients with asthma. Two complementary techniques that can determine the infection status withT. canis and rule out cross ‐reactions involve the detection of L3TES and IgG using sera preadsorbed withAscaris antigen. There was no significant association among asthma severity, ACQ andT. canis seroprevalence. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2021 Category: Allergy & Immunology Authors: Bautista ‐García Sandra Guadalupe, Martínez‐Gordillo Mario Noé, Peralta‐Abarca Gustavo Esteban, González‐Bobadilla Norma Yvett, Clavijo‐Sánchez Karina, Chávez‐Zea Alma Leticia, Hernández‐Saavedra Alan Eduardo, Huerta‐López J Tags: ORIGINAL RESEARCH Source Type: research

Kinetics and prognostic value of soluble VCAM ‐1 in ST‐segment elevation myocardial infarction patients
ConclusionsIn STEMI patients, high sVCAM ‐1 levels are associated with a poor clinical outcome. sVCAM‐1 is an early postmyocardial infarction biomarker and might be an interesting target for the development of future therapeutic strategies. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 9, 2021 Category: Allergy & Immunology Authors: Ahmad Hayek, Alexandre Paccalet, Laura Mechtouff, Claire C. Da Silva, Fabrice Ivanes, Hadrien Falque, Simon Leboube, Yvonne Varillon, Camille Amaz, Charles Bourguignon, Cyril Prieur, Danka Tomasevic, Nathalie Genot, Fran çois Derimay, Eric Tags: ORIGINAL RESEARCH Source Type: research

Safety of hydroxychloroquine for treatment or prevention of SARS ‐CoV‐2 infection: A rapid systematic review and meta‐analysis of randomized clinical trials
ConclusionSafety profile of HCQ appears to be unsatisfactory when used to treat or prevent COVID ‐19, especially in the light of unproved clinical benefit. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Alberto Enrico Maraolo, Adriano Grossi Tags: REVIEW Source Type: research

Does COVID ‐19 contribute to development of neurological disease?
ConclusionThis review correlates present clinical manifestations of COVID ‐19 patients with possible neurological consequences in the future, thus preparing healthcare providers for possible future consequences of COVID‐19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Shasthara Paneyala, Duraisamy Patteswari, Meena Kishore Sakharkar, Hamdan Hamdan, David M. Ojcius, Srinivasa Rao Bolla, Musthafa Mohamed Essa, Saravana Babu Chidambaram, M. Walid Tags: REVIEW Source Type: research

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease
This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity a nd NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Yunfei Luo, Hui Lin Tags: REVIEW Source Type: research

Animal models of rheumatoid arthritis ‐associated interstitial lung disease
ConclusionThese established animal models of the disease can significantly progress our understanding of the etiology of RA ‐ILD, the fundamental mechanisms of its pathogenesis and the identification of new bio‐markers, and can contribute to the development and implementation of novel treatment strategies. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Li Xiong, Liang Xiong, Hong Ye, Wan ‐Li Ma Tags: REVIEW Source Type: research

The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
ConclusionsHMGB1 plays an important role in a variety of pediatric diseases and may be used as a diagnostic biomarker and therapeutic target for new strategies for the prevention and treatment of pediatric diseases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le Tags: REVIEW Source Type: research

Issue Information
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Clinical efficacy and safety of omalizumab in conventional treatment ‐resistant vernal keratoconjunctivitis: Our experience and literature review
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Gian Luigi Marseglia, Amelia Licari, Salvatore Leonardi Tags: EDITORIAL Source Type: research

Rhinovirus remains prevalent in school teenagers during fight against COVID ‐19 pandemic
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Di Wu, Jianyun Lu, Zhangyu Sun, Lan Cao, Qing Zeng, Qun Liu, Tiantian Wu, Zhicong Yang Tags: COMMENTARY Source Type: research

Allergy protection at farms —just a myth?
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Matthias Wjst Tags: COMMENTARY Source Type: research

Dec2 attenuates autophagy in inflamed periodontal tissues
ConclusionsThese results demonstrate that a Dec2 deficiency can alleviate LPS ‐induced inflammation via the ERK/mTOR signaling pathway by regulating autophagy, conceivably delivering a novel approach for the detection of periodontal treatments. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Shunichi Oka, Xiaoyan Li, Fuyuki Sato, Fengzhu Zhang, Nitesh Tewari, Chongchong Chen, Liangjun Zhong, Makoto Makishima, Yi Liu, Ujjal K. Bhawal Tags: ORIGINAL RESEARCH Source Type: research

Separate signaling events control TCR downregulation and T cell activation in primary human T cells
ConclusionsThese data suggest that there is substantial redundancy in the contribution of individual tyrosine kinases to TCR downregulation in primary human T cells. Our results highlight that TCR downregulation and T cell activation are controlled by different signaling events and illustrate the need for further research to untangle these processes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Lieve E. H. Donk, Louis S. Ates, Jet Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. Heijst Tags: ORIGINAL RESEARCH Source Type: research

Enhanced IgG1 ‐mediated antibody response towards thymus‐dependent immunization in CXCR1‐deficient mice
ConclusionOur data demonstrate a previously unknown relevance of CXCR1 for the production of specific IgG1 in response to vaccination. These findings identify CXCR1 as a promising candidate for future studies on the regulation of adaptive antibody responses. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Jennifer Jaufmann, Melanie Carevic, Leyla T ümen, Derya Eliacik, Fee Schmitt, Dominik Hartl, Sandra Beer‐Hammer Tags: ORIGINAL RESEARCH Source Type: research

Evidence and implications of pre ‐existing humoral cross‐reactive immunity to SARS‐CoV‐2
ConclusionAlthough the clinical relevance of the observed reactivity can only be speculated and needs to be investigated, the implication of this finding for coronavirus disease 2019 seroepidemiological survey and vaccines' clinical trials is critical. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Amandine Mveang Nzoghe, Paulin N. Essone, Marielle Leboueny, Anicet Christel Maloupazoa Siawaya, Eliode Cyrien Bongho, Ofilia Mvoundza Ndjindji, Rotimi Myrabelle Avome Houechenou, Selidji Todagbe Agnandji, Joel Fleury Djoba Siawaya Tags: ORIGINAL RESEARCH Source Type: research

Development of improved method to identify and analyze lung fibrocytes with flow cytometry in a reporter mouse strain
ConclusionOur findings suggest that the improved method can be a useful for the detection of pure lung fibrocytes and allows us to further analyze the characteristics of viable fibrocytes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Hiroshi Kawano, Kazuya Koyama, Haruka Nishimura, Yuko Toyoda, Kozo Kagawa, Seidai Sato, Nobuhito Naito, Hisatsugu Goto, Yutaka Inagaki, Yasuhiko Nishioka Tags: ORIGINAL RESEARCH Source Type: research

Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis
ConclusionsUnderstanding natural dynamics of CRS ‐associated tissues is essential to provide baseline context for all studies on putative biomarkers, mechanisms, and subtypes of CRS. These data further our understanding of the natural dynamics within nasal polypoid tissue, as well as local changes in response to systemic corticosteroid therapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Michael Hoggard, Bincy Jacob, David Wheeler, Melissa Zoing, Kevin Chang, Kristi Biswas, Martin Middleditch, Richard G. Douglas, Michael W. Taylor Tags: ORIGINAL RESEARCH Source Type: research

The BTLA and PD ‐1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells
ConclusionThese results suggest that BTLA signaling is crucial in regulating γδ T cell proliferation and function and that the BTLA and PD‐1 signaling pathways act independently on the proliferation and cytotoxicity of human peripheral γδ T cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Hyun J. Hwang, Jae J. Lee, Sung H. Kang, Jin K. Suh, Eun S. Choi, Seongsoo Jang, Sang ‐Hyun Hwang, Kyung‐Nam Koh, Ho J. Im, Nayoung Kim Tags: ORIGINAL RESEARCH Source Type: research

Impaired interferon ‐α expression in plasmacytoid dendritic cells in asthma
ConclusionOur study discovered the response to TLR ‐7 stimulation in pDCs was compromised and the sustainability of interferon‐α expression to RV stimulation was reduced in pDCs of asthmatic patients, which provide further evidence of defective innate response and subspeciality to RV infection in asthma. The high exacerbation history founded in RV+ patients agrees with these findings. Further research is required for the modulatory effect of IL‐4 on TLR‐7 stimulated pDCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Ting ‐Yu Lin, Chun‐Yu Lo, Kuo‐Chien Tsao, Po‐Jui Chang, Chih‐His Scott Kuo, Yu‐Lun Lo, Shu‐Min Lin, Meng‐Heng Hsieh, Tsai‐Yu Wang, Ping‐Chih Hsu, Horng‐Chyuan Lin Tags: ORIGINAL RESEARCH Source Type: research

Silenced SOX2 ‐OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR‐2355‐3p
ConclusionsSilencing SOX2 ‐OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR‐2355‐3p. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Yuming Liang, Boqun Wang, Huijuan Huang, Maoyun Wang, Qianwen Wu, Yaxin Zhao, Yan He Tags: ORIGINAL RESEARCH Source Type: research

Eradication of hepatitis C virus infection in kidney transplant recipients using direct ‐acting antiviral therapy: Qatar experience
ConclusionsHCV infection was successfully eradicated by DAA therapy in kidney transplant recipients, with a 100% SVR rate. Moreover, DAA therapy was well ‐tolerated, and kidney function remained stable without an increased risk of rejection. These results are expected to drive the eradication of hepatitis C from the entire country. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Mohamad M. Alkadi, Essa A. Abuhelaiqa, Mostafa F. Elshirbeny, Ahmed F. Hamdi, Omar M. Fituri, Muhammad Asim, Saad R. Alkaabi, Moutaz F. Derbala, Mona E. Jarman, Adel M. Ashour, Awais Nauman, Yousuf K. Al Maslamani, Adeel A. Butt, Hassan A. Al Tags: ORIGINAL RESEARCH Source Type: research

Association of a four ‐gene model with allergic diseases: Two‐year follow‐up of a birth cohort study
ConclusionThe gene model was significantly associated with the development of eczema in Chinese Han toddlers. Long ‐term follow‐up along with functional and replication studies on the gene model are still needed in future. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Li Hua, Fen Yang, Qian Chen, Quanhua Liu, Ruoxu Ji, Haipei Liu, Jianmin Ye, Jun Zhang, Jianhua Zhang, Yixiao Bao Tags: ORIGINAL RESEARCH Source Type: research

Factors affecting upper airway control of NSAID ‐exacerbated respiratory disease: A real‐world study of 167 patients
ConclusionsNasal polyp eosinophilia, baseline OCS, and a history of recurrent ESS predict uncontrolled N ‐ERD. These factors might be clinically useful in risk‐estimation of uncontrolled disease and for organizing follow‐ups. Prospective cohort studies with larger sample size are needed to further study the factors affecting the upper airway control of N‐ERD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Annina Lyly, Anu Laulajainen ‐Hongisto, Heikki Turpeinen, Seija I. Vento, Jyri Myller, Jura Numminen, Saara Sillanpää, Johanna Sahlman, Paula Kauppi, Sanna Toppila‐Salmi Tags: ORIGINAL RESEARCH Source Type: research

miR ‐223 improves intestinal inflammation through inhibiting the IL‐6/STAT3 signaling pathway in dextran sodium sulfate‐induced experimental colitis
ConclusionsThe upregulation of miR ‐223 by agomir administration alleviated colonic inflammation in a DSS‐induced colitis model, which was likely mediated by inhibiting the production of pro‐inflammatory cytokines via the IL‐6/STAT3 signaling pathway. These findings provide evidence that miR‐223 might have potential therape utic implications in IBD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Juanjuan Zhang, Chenyang Wang, Zhen Guo, Binlin Da, Weiming Zhu, Qiurong Li Tags: ORIGINAL RESEARCH Source Type: research

Serum soluble PD ‐1 plays a role in predicting infection complications in patients with acute pancreatitis
ConclusionSerum sPD ‐1/sPD‐L1 may be involved in the immunosuppressive process in AP. Moreover, the serum sPD‐1 level may be an independent risk factor for predicting ICs in AP patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 4, 2021 Category: Allergy & Immunology Authors: Xingxing Yu, Yu Pan, Qinglin Fei, Xianchao Lin, Zhijiang Chen, Heguang Huang Tags: ORIGINAL RESEARCH Source Type: research