Decreased numbers of metachromatic cells in nasal swabs in Japanese cedar pollinosis following sublingual immunotherapy
The mechanisms underlying the effectiveness of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis are poorly understood. One of mechanisms is a reduction of the number of metachromatic cells and eosinophils. AbstractBackground and ObjectiveNasal symptoms were reduced following allergen ‐specific sublingual immunotherapy (SLIT) for allergic rhinitis. The mechanisms underlying the effectiveness of SLIT for Japanese cedar pollinosis are poorly understood. We studied changes in the numbers of metachromatic cells, eosinophils, and neutrophils following SLIT for Japanese cedar pollino sis.MethodsNasal swabs were tak...
Source: Immunity, Inflammation and Disease - May 28, 2020 Category: Allergy & Immunology Authors: Kuninori Otsuka, Hirokuni Otsuka, Shoji Matsune, Kimihiro Okubo Tags: ORIGINAL RESEARCH Source Type: research

Lymphopenia and lymphocytosis in practical healthy people born and living in the North
ConclusionsThe main mechanism for the formation of lymphopenia and lymphocytosis in healthy people was established. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 16, 2020 Category: Allergy & Immunology Authors: Veronika P. Patrakeeva, Liliya K. Dobrodeeva Tags: ORIGINAL RESEARCH Source Type: research

Respiratory infections regulated blood cells IFN ‐β‐PD‐L1 pathway in pediatric asthma
Conclusions and Clinical RelevanceThese data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with inducedPD ‐L1 mRNA expression in blood cells. Further, type I IFN, IFN ‐β, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD‐L1 expression in blood cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 12, 2020 Category: Allergy & Immunology Authors: Julia K ölle, Patricia Haag, Tytti Vuorinen, Kiefer Alexander, Manfred Rauh, Theodor Zimmermann, Nikolaos G. Papadopoulos, Susetta Finotto Tags: ORIGINAL RESEARCH Source Type: research

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(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 10, 2020 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Geographic location determines beta ‐cell autoimmunity among adult Ghanaians: Findings from the RODAM study
ConclusionGeographic location determines the occurrence of GAD65Ab and ZnT8Ab more than the diabetes status. Beta ‐cell autoimmunity may not be feasible to differentiate diabetes subgroups in this population. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 7, 2020 Category: Allergy & Immunology Authors: Christiane S. Hampe, Diomira Sahabandu, Vivien Kaiser, Tanja Telieps, Liam Smeeth, Charles Agyemang, Joachim Spranger, Matthias B. Schulze, Frank P. Mockenhaupt, Ina Danquah, Olov Rolandsson Tags: ORIGINAL RESEARCH Source Type: research

Successful introduction of milk after a negative double ‐blind placebo‐controlled food challenge test is independent of the total dose and milk product used during the challenge test
We evaluated the success rate of milk introduction after negative food challenge tests performed with different doses of milk protein and different milk products. Successful introduction of milk was independent of the total dose of milk protein, and milk product used during the challenge test. AbstractBackgroundFailure of milk introduction after a negative food challenge test is reported in a substantial number of patients. For this reason, guidelines recommend that the total dose of milk protein for a food challenge test should be comparable to a normal serving.ObjectiveOur aim is to compare the success rate of milk intro...
Source: Immunity, Inflammation and Disease - April 22, 2020 Category: Allergy & Immunology Authors: Celine A. Ven, Irene Herpertz, Lidy Lente, Gerbrich N. Meulen, Arvid W. A. Kamps Tags: ORIGINAL RESEARCH Source Type: research

Characterization of humoral immune responses and degree of protection induced by influenza vaccine in cotton rats: Effects of low vaccine dose and single vs booster vaccination
ConclusionOur data suggest that complete and partial protection by influenza vaccines can be mimicked in cotton rats by using specific vaccination regimens. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 22, 2020 Category: Allergy & Immunology Authors: Yoshita Bhide, Wei Dong, Tjarko Meijerhof, Jacqueline Vries ‐Idema, Hubert G. Niesters, Anke Huckriede Tags: ORIGINAL RESEARCH Source Type: research

Allergen ‐specific subcutaneous immunotherapy for Japanese cedar pollinosis decreases the number of metachromatic cells and eosinophils in nasal swabs during the preseason and in season
The number of metachromatic cells in nasal swabs in untreated subjects (B) and SCIT (C) for Japanese cedar pollinosis in pre ‐season and in season. AbstractBackground and objectiveNasal symptoms of allergic rhinitis can be reduced with allergen ‐specific subcutaneous immunotherapy (SCIT). However, the mechanisms underlying the effectiveness of SCIT for Japanese cedar pollinosis are not well understood. We studied changes in the numbers of metachromatic cells, eosinophils and neutrophils in nasal swabs following SCIT for Japanese cedar po llinosis.MethodsSubjects were either untreated or given SCIT for 0.5 to 13 years d...
Source: Immunity, Inflammation and Disease - April 2, 2020 Category: Allergy & Immunology Authors: Kuninori Otsuka, Hirokuni Otsuka, Shoji Matsune, Kimihiro Okubo Tags: ORIGINAL RESEARCH Source Type: research

Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England
ConclusionThis study provides insights into current asthma management practices in the US and England and indicates that some patients with severe disease have an unmet need for effective management. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 31, 2020 Category: Allergy & Immunology Authors: Mugdha Gokhale, Takako Hattori, Lee Evitt, Warren Lenney, Beth Nordstrom, Jenna Collins, Anna Schultze, Melissa K. Van Dyke Tags: ORIGINAL RESEARCH Source Type: research

Human mast cells exhibit an individualized pattern of antimicrobial responses
ConclusionsThus, hMCs exhibit a highly individualized pattern of immune response possibly to meet tissue requirements and regulate bacteria coexistence vs defense. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 31, 2020 Category: Allergy & Immunology Authors: Karen M. Garcia ‐Rodriguez, Rajia Bahri, Clara Sattentau, Ian S. Roberts, Anu Goenka, Silvia Bulfone‐Paus Tags: ORIGINAL RESEARCH Source Type: research

α2AP is associated with the development of lupus nephritis through the regulation of plasmin inhibition and inflammatory responses
Conclusionα2AP regulates the inflammatory responses through plasmin inhibition and proinflammatory cytokine production and is associated with the development of LN. Our findings may be used to develop a novel therapeutic approach for SLE. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 31, 2020 Category: Allergy & Immunology Authors: Yosuke Kanno, Mei Miyashita, Mariko Seishima, Osamu Matsuo Tags: ORIGINAL RESEARCH Source Type: research

Chronic viral infections impinge on naive bystander CD8 T cells
ConclusionsOur results document numeric, phenotypic, and functional adaptation of bystander naive CD8 T cells during nonrelated chronic viral infection. Their functional impairment was only evident in the chronically infected host, indicating that T ‐cell extrinsic factors, in particular the quality of priming APCs, are responsible for the impaired function of naive bystander T cells in the chronically infected hosts. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 28, 2020 Category: Allergy & Immunology Authors: Isabel Barnstorf, Suzanne P. M. Welten, Mariana Borsa, Nicolas S. Baumann, Katharina Pallmer, Nicole Joller, Roman Sp örri, Annette Oxenius Tags: ORIGINAL RESEARCH Source Type: research

Peanut applied to the skin of nonhuman primates induces antigen ‐specific IgG but not IgE
ConclusionsSkin exposure to peanut did not lead to sensitization in this study, and monkeys did not experience anaphylaxis upon peanut challenge. However, monkeys produced increased peanut ‐specific IgG throughout peanut exposure, indicating that repeated skin exposure to peanut is immunogenic. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 28, 2020 Category: Allergy & Immunology Authors: Michael D. Kulis, Johanna M. Smeekens, Kylie Kavanagh, Matthew J. Jorgensen Tags: ORIGINAL RESEARCH Source Type: research

Detection of amastigotes and histopathological alterations in the thymus of Leishmania infantum ‐infected dogs
ConclusionsThese results demonstrate that the thymus of dogs can be parasitized byL. infantum, which may generate inflammatory reactions leading to alterations in thymic microarchitecture. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 25, 2020 Category: Allergy & Immunology Authors: Aurea V. A. Silva, Tain ã L. Souza, Fabiano B. Figueiredo, Artur A. V. Mendes, Luiz C. Ferreira, Camila P. B. Filgueira, Patricia Cuervo, Renato Porrozzi, Rodrigo C. Menezes, Fernanda N. Morgado Tags: ORIGINAL RESEARCH Source Type: research

Dose response of black American mink to Aleutian mink disease virus
ConclusionsCIEP is more accurate than PCR for detecting AMDV infection in mink. Using antibody titer in naturally infected mink may not be accurate for the identification of tolerant mink. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 18, 2020 Category: Allergy & Immunology Authors: A. Hossain Farid, Irshad Hussain Tags: ORIGINAL RESEARCH Source Type: research

Evaluation of glycoprotein E subunit and live attenuated varicella ‐zoster virus vaccines formulated with a single‐strand RNA‐based adjuvant
ConclusionsTaken together, these results highlight that the gE subunit vaccine and LAV developed in this study can be functional VZV vaccines, and ssRNAs appear to function better as adjuvants in a subunit vaccine than in an LAV. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 18, 2020 Category: Allergy & Immunology Authors: Su Jeen Lee, Hyo ‐Jung Park, Hae Li Ko, Jung Eun Lee, Hyun Joo Lee, Hun Kim, Jae‐Hwan Nam Tags: ORIGINAL RESEARCH Source Type: research

Excessive ADAM17 activation occurs in uremic patients and may contribute to their immunocompromised status
ConclusionsWe concluded that abnormal ADAM17 activation could contribute to the immunocompromised status in patients on HD, in line with the reported role of ADAM17 as an anti ‐inflammatory and immunosuppressive factor. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 18, 2020 Category: Allergy & Immunology Authors: Mitsuru Yashiro, Masaki Ohya, Toru Mima, Yuri Nakashima, Kazuki Kawakami, Tomohiro Sonou, Koichi Tatsuta, Yukiko Yamano, Shigeo Negi, Takashi Shigematsu Tags: ORIGINAL RESEARCH Source Type: research

Allergen ‐specific immunotherapy for patients with atopic dermatitis sensitized to animal dander
ConclusionAlthough a larger number of patients for a longer follow ‐up period are needed to precisely assess the treatment efficacy, AIT using cat and/or dog dander may be an effective treatment option for AD patients, especially for severe AD patients with other respiratory allergic comorbidities who cannot completely avoid the exposure to animal dander. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 12, 2020 Category: Allergy & Immunology Authors: Howard Chu, Kyung Hee Park, Su Min Kim, Jae ‐Hyun Lee, Jung‐Won Park, Kwang Hoon Lee, Chang Ook Park Tags: ORIGINAL RESEARCH Source Type: research

Changes in passively ‐sensitized basophil activation to αS1‐casein after oral immunotherapy
ConclusionsαS1‐casein‐sIgG4 plays a minor role in tolerance mechanisms in cases of CMA; humoral factors other than antigen‐sIgG4 may be involved. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 4, 2020 Category: Allergy & Immunology Authors: Teruaki Matsui, Michihiro Naito, Kazunori Tagami, Iwao Tajima, Miyuki Teshigawara, Atsushi Makino, Katsumasa Kitamura, Yoshihiro Takasato, Shiro Sugiura, Chikako Yamada, Hidehiko Izumi, Ikuya Tsuge, Yasuto Kondo, Komei Ito Tags: ORIGINAL RESEARCH Source Type: research

Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma
ConclusionsThese results suggest that the reduction of AMs has a stronger impact on restricting tumor progression compared with targeting IMs. The depletion of AMs leads to an elevated infiltration of CD8+ T cells into the lung that might be responsible for tumor growth impairment. Altogether, elimination of AMs is a better strategy to reduce EGFR mutant tumor growth and is less toxic, suggesting the selectively targeting of AMs to complement established therapies. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 4, 2020 Category: Allergy & Immunology Authors: Kristina Alikhanyan, Yuanyuan Chen, Simone Kraut, Rocio Sotillo Tags: ORIGINAL RESEARCH Source Type: research

A well ‐tolerated new amino acid–based formula for cow's milk allergy
ConclusionsThe study formula meets the American Academy of Pediatric criteria for hypoallergenicity and is well tolerated in short ‐term use. During optional phase, growth of the patients was not hindered by the study formula. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - March 2, 2020 Category: Allergy & Immunology Authors: Vincenzo Fierro, Rocco L. Valluzzi, Claudia Banzato, Ma A. Plaza, Montserrat Bosque, Marcel Íbero, Luis A. Z. Echeverría, Maurizio Mennini, Lamia Dahdah, Roser Castellar, Gloria Tort, Jesus Jiménez Tags: ORIGINAL RESEARCH Source Type: research

Interleukin ‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6
ConclusionTogether, the estimations and the measurements support the notion that target cells with more than 100 bioactive cytokine receptors per cell, such as T cells and hepatocytes, are likely to be under steady and substantial cytokine ‐induced endocrine activation. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 28, 2020 Category: Allergy & Immunology Authors: Morten B. Hansen Tags: ORIGINAL RESEARCH Source Type: research

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(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 15, 2020 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Circulating mucosal ‐associated invariant T cells in subjects with recurrent urinary tract infections are functionally impaired
ConclusionCirculating MAIT cells in immunocompetent individuals with RUTIs respond to bacterial stimuli with reduced efficacy, which suggests that they are involved in the pathogenesis of RUTIs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 10, 2020 Category: Allergy & Immunology Authors: Matty L. Terpstra, Ester B. M. Remmerswaal, Michiel C. Aalderen, Joyce J. Wever, Marjan J. Sinnige, Nelly D. Bom ‐Baylon, Frederike J. Bemelman, Suzanne E. Geerlings Tags: ORIGINAL RESEARCH Source Type: research

Role of the interferons in CD64 and CD169 expressions in whole blood: Relevance in the balance between viral ‐ or bacterial‐oriented immune responses
ConclusionsThe induction of CD169 on monocytes and CD164 on neutrophils by type I and type II IFNs confirms the relevance of these markers for assessing between a viral ‐ vs bacterial‐oriented immune response. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 7, 2020 Category: Allergy & Immunology Authors: P énélope Bourgoin, Géraldine Biéchelé, Inès Ait Belkacem, Pierre‐Emmanuel Morange, Fabrice Malergue Tags: ORIGINAL RESEARCH Source Type: research

A free amino acid ‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey
ConclusionThis study demonstrates that an AA ‐based diet can at least partially prevent allergic symptoms of CMA in mice. Differences in FoxP3+ cell counts and serum levels of IgG2a and IgG1 may suggest enhanced anti ‐inflammatory and tolerizing capacities in AA‐fed mice. This, combined with the absence of effects in sham‐sensitized mice indicates that AAFs for the prevention of food allergies may be an interesting concept that warrants further research. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - February 7, 2020 Category: Allergy & Immunology Authors: Joris H. J. Sadelhoff, Astrid Hogenkamp, Selma P. Wiertsema, Lucien F. Harthoorn, Reinilde Loonstra, Anita Hartog, Johan Garssen Tags: ORIGINAL RESEARCH Source Type: research

Identification and characterization of protective CD8+ T ‐epitopes in a malaria vaccine candidate SLTRiP
ConclusionOur findings show that the protective efficacy shown by SLTRiP is localized in particular protein fragments. The peptides designed from such regions showed protective efficacy equivalent to whole protein. The sequence conservation analysis with humanPlasmodium species also showed that these peptides were conserved. In conclusion, these peptides or their equivalent from otherPlasmodium species could impart protection against malaria in their respective hosts too. Our studies provide a basis for the inclusion of these peptides in clinical vaccine constructs against malaria. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 22, 2020 Category: Allergy & Immunology Authors: Afshana Quadiri, Inderjeet Kalia, Mohammad Kashif, Agam P. Singh Tags: ORIGINAL RESEARCH Source Type: research

Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor ‐κB inflammatory signaling pathway in human skin cells
ConclusionOur results offer a mechanistic model forC. t. ‐induced inflammation in human keratinocytes via TLR2 and activation of I κB kinase and downstream signaling through the canonical NF‐κB pathway. Relevance to chronic inflammatory diseases of the skin and cutaneous oncology is discussed. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 7, 2020 Category: Allergy & Immunology Authors: Mohammed O. Altonsy, Habib A. Kurwa, Gilles J. Lauzon, Matthias Amrein, Anthony N. Gerber, Wagdi Almishri, Paule R égine Mydlarski Tags: ORIGINAL RESEARCH Source Type: research

Corynebacterium tuberculostearicum, a human skin colonizer, induce  the canonical nuclear factor‐κB inflammatory signaling pathway in the human skin cells
ConclusionOur results offer a mechanistic model forC. t. ‐induced inflammation in human keratinocytes via TLR2 and activation of I κB kinase and downstream signaling through the canonical NF‐κB pathway. Relevance to chronic inflammatory diseases of the skin and cutaneous oncology is discussed. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 7, 2020 Category: Allergy & Immunology Authors: Mohammed O. Altonsy, Habib A. Kurwa, Gilles J. Lauzon, Matthias Amrein, Anthony N. Gerber, Wagdi Almishri, Paule R égine Mydlarski Tags: ORIGINAL RESEARCH Source Type: research

Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma
Conclusions and Clinical RelevanceThere was increased expression ofDNASE1L3 in asthma andIL1B in neutrophilic asthma. These results show similar upregulated patterns of expression in two genes of the 6GS in endobronchial biopsies, previously identified in sputum. The upregulation ofDNASE1L3 andIL1B suggests that common mechanisms may be at play throughout the airway. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 5, 2020 Category: Allergy & Immunology Authors: Stephany S ánchez‐Ovando, Katherine J. Baines, Daniel Barker, Peter A. Wark, Jodie L. Simpson Tags: ORIGINAL RESEARCH Source Type: research

Impaired tumor necrosis factor ‐α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze
ConclusionsWe demonstrated lower TNF ‐α production by in vitro stimulated CD4+ T cells during severe RSV bronchiolitis in children that subsequently developed recurrent wheezing, compared with children with no subsequent wheeze. These findings support the role of CD4+ T cell immunity in the development of subsequent wheezing in thes e children. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 4, 2020 Category: Allergy & Immunology Authors: Maleewan Kitcharoensakkul, Leonard B. Bacharier, Huiqing Yin ‐Declue, Jonathan S. Boomer, Geneline Sajol, Marilyn K. Leung, Brad Wilson, Kenneth B. Schechtman, John P. Atkinson, Jonathan M. Green, Mario Castro Tags: ORIGINAL RESEARCH Source Type: research

Atopy patch tests may identify patients at risk for systemic contact dermatitis
ConclusionOur aggregate findings suggest that most APTs, but not dust mite, behave like conventional patch tests to low ‐potency allergens. They are more likely to be positive in patients with chronically inflamed skin and to identify allergens that cause SCD. The higher prevalence of APT positivity to foods in young children is consistent with food allergy as a trigger of AD (also known as SCD) being more common i n children than adults. Positive APTs define patients who may have SCD; negative APTs may guide elimination diets. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 11, 2019 Category: Allergy & Immunology Authors: Suwimon Pootongkam, Sonia A. Havele, Hanna Orillaza, Eli Silver, Douglas Y. Rowland, Susan T. Nedorost Tags: ORIGINAL RESEARCH Source Type: research

Role of ocular cytology in vernal keratoconjunctivitis
ConclusionGiven the ease of performance, when conducting further longitudinal studies, the conjunctival cytology examination could be used, on the one hand, to diagnose VKC, especially when the clinical diagnosis is uncertain, and, on the other, to follow disease evolution and monitor the response to topical treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 5, 2019 Category: Allergy & Immunology Authors: Gaia Bruschi, Daniele G. Ghiglioni, Silvia Osnaghi, Chiara Rosazza, Denise Pires Marafon, Massimo Landi, Paola G. Marchisio Tags: ORIGINAL RESEARCH Source Type: research

PD ‐1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator‐activated receptor‐γ
ConclusionsThese findings illustrate that chronic loss of PD ‐1 plays a role in ILC2 function and PD‐1 expression can be modulated by PPAR‐γ. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 19, 2019 Category: Allergy & Immunology Authors: Banu Batyrova, Fien Luwaert, Panagiota Maravelia, Yuria Miyabayashi, Neha Vashist, Julian M. Stark, Sara Y. Soori, Christopher A. Tibbitt, Peggy Riese, Jonathan M. Coquet, Benedict J. Chambers Tags: ORIGINAL RESEARCH Source Type: research

The use of amino acid ‐based nutritional feeds is effective in the dietary management of pediatric eosinophilic oesophagitis
ConclusionsThe use of AAF is a clinically effective management option for pediatric EoE, and further research is required to guide long ‐term management. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Authors: Kiranjit Atwal, Gary P. Hubbard, Carina Venter, Rebecca J. Stratton Tags: REVIEW Source Type: research

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(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection
ConclusionThis is the first report to demonstrate a significant reduction of lymphocytes and multiple proinflammatory chemokines in the lungs following ischemic stroke in mice. These findings suggest that ischemic stroke directly impacts pulmonary immunity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Authors: Breanne Y. Farris, Kelly L. Monaghan, Wen Zheng, Courtney D. Amend, Heng Hu, Amanda G. Ammer, James E. Coad, Xuefang Ren, Edwin C. K. Wan Tags: ORIGINAL RESEARCH Source Type: research

Complexin 2 regulates secretion of immunoglobulin in antibody ‐secreting cells
ConclusionOur data suggest that CPLX2 inhibits spontaneous secretion of IgM and IgG1 from splenic ASCs. This study provides new insight into the mechanism of antibody secretion of ASCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Authors: Emi Tsuru, Kohei Oryu, Ken Sawada, Makoto Nishihara, Masayuki Tsuda Tags: ORIGINAL RESEARCH Source Type: research

The expression and methylation status of vitamin D receptor gene in Behcet's disease
ConclusionVDR gene expression decreased in patients with BD. However, there is no suggestion evidence that the expression level of VDR is regulated by a unique DNA methylation mechanism. No correlation exists betweenVDR gene expression and BD activity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Authors: Sam Seydi Shirvani, Mohammad Nouri, Ebrahim Sakhinia, Zohreh Babaloo, Golamreza jadideslam, Alipour Shahriar, Jafar Farhadi, Alireza khabbazi Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

The use of amino acid ‐based nutritional feeds is effective in the dietary management of pediatric eosinophilic oesophagitis
ConclusionsThe use of AAF is a clinically effective management option for pediatric EoE, and further research is required to guide long ‐term management. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 6, 2019 Category: Allergy & Immunology Authors: Kiranjit Atwal, Gary P. Hubbard, Carina Venter, Rebecca J. Stratton Tags: REVIEW Source Type: research

Complexin 2 regulates secretion of immunoglobulin in antibody ‐secreting cells
ConclusionOur data suggest that CPLX2 inhibits spontaneous secretion of IgM and IgG1 from splenic ASCs. This study provides new insight into the mechanism of antibody secretion of ASCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 5, 2019 Category: Allergy & Immunology Authors: Emi Tsuru, Kohei Oryu, Ken Sawada, Makoto Nishihara, Masayuki Tsuda Tags: ORIGINAL RESEARCH Source Type: research

Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection
ConclusionThis is the first report to demonstrate a significant reduction of lymphocytes and multiple proinflammatory chemokines in the lungs following ischemic stroke in mice. These findings suggest that ischemic stroke directly impacts pulmonary immunity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 5, 2019 Category: Allergy & Immunology Authors: Breanne Y. Farris, Kelly L. Monaghan, Wen Zheng, Courtney D. Amend, Heng Hu, Amanda G. Ammer, James E. Coad, Xuefang Ren, Edwin C. K. Wan Tags: ORIGINAL RESEARCH Source Type: research

Complexin 2 regulates secretion of immunoglobulin in antibody ‐secreting cells
ConclusionOur data suggest that CPLX2 inhibits spontaneous secretion of IgM and IgG1 from splenic ASCs. This study provides new insight into the mechanism of antibody secretion of ASCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 5, 2019 Category: Allergy & Immunology Authors: Emi Tsuru, Kohei Oryu, Ken Sawada, Makoto Nishihara, Masayuki Tsuda Tags: ORIGINAL RESEARCH Source Type: research

Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection
ConclusionThis is the first report to demonstrate a significant reduction of lymphocytes and multiple proinflammatory chemokines in the lungs following ischemic stroke in mice. These findings suggest that ischemic stroke directly impacts pulmonary immunity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 5, 2019 Category: Allergy & Immunology Authors: Breanne Y. Farris, Kelly L. Monaghan, Wen Zheng, Courtney D. Amend, Heng Hu, Amanda G. Ammer, James E. Coad, Xuefang Ren, Edwin C. K. Wan Tags: ORIGINAL RESEARCH Source Type: research

Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome
ConclusionsThis pilot study demonstrates that IBS patients have a significantly higher prevalence of hypersensitivity to zinc and nickel, suggesting the possible involvement of dental metal hypersensitivity in IBS pathogenesis in a subset of patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 24, 2019 Category: Allergy & Immunology Authors: Yasunari Kageyama, Koichi Aida, Kimihiko Kawauchi, Masafumi Morimoto, Tetsu Akiyama, Tsutomu Nakamura Tags: ORIGINAL RESEARCH Source Type: research