Development of a prognostic index based on immunogenomic landscape analysis in glioma
ConclusionThis study demonstrates the importance of an IRG ‐based prognostic index as a potential biomarker for predicting malignancy in gliomas. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 27, 2021 Category: Allergy & Immunology Authors: Haitao Luo, Chuming Tao, Peng Wang, Jingying Li, Kai Huang, Xingen Zhu Tags: ORIGINAL RESEARCH Source Type: research

Anti ‐dsDNA, anti‐nucleosome, anti‐C1q, and anti‐histone antibodies as markers of active lupus nephritis and systemic lupus erythematosus disease activity
This study aimed at evaluating the value of these autoantibodies in active LN, and their performance on cross‐sectional evaluating and longitudinal monitoring of SLE disease activity.MethodsSerum levels of four autoantibodies in 114 SLE patients, 219 other autoimmune disease patients (OAD), and 59 healthy controls were assayed by a quantitative immunoassay. Sera of 38 inpatients were obtained again after treatment.ResultsWe found that serum levels of four autoantibodies were significantly higher in SLE than OAD patients (p 
Source: Immunity, Inflammation and Disease - January 20, 2021 Category: Allergy & Immunology Authors: Xiaoying Shang, Lisheng Ren, Guirong Sun, Teng Yu, Yuan Yao, Lin Wang, Fenghai Liu, Lijun Zhang, Xiaqin He, Mingjun Liu Tags: ORIGINAL RESEARCH Source Type: research

Enhanced airway hyperresponsiveness in asthmatic children and mice with A(H1N1)pdm09 infection
In this study, airway hyperresponsiveness (AHR) was measured in pediatric asthma patients infected with A(H1N1)pdm09. We also evaluated AHR in asthmatic mice with A(H1N1)pdm09 infection and those with seasonal influenza for comparison.MethodsAHRs in asthmatic children were defined as the provocative acetylcholine concentration causing a 20% reduction in forced expiratory volume in 1  s (PC20). To investigate the pathophysiology using animal models, BALB/c mice aged 6 ‐8 weeks were sensitized and challenged with ovalbumin. Either mouse‐adapted A(H1N1)pdm09, seasonal H1N1 virus (1 × 105 pfu/20 ...
Source: Immunity, Inflammation and Disease - January 20, 2021 Category: Allergy & Immunology Authors: Taira Ariyoshi, Junichiro Tezuka, Hiroki Yasudo, Yasufumi Sakata, Tamaki Nakamura, Takeshi Matsushige, Hideki Hasegawa, Noriko Nakajima, Akira Ainai, Atsunori Oga, Hiroshi Itoh, Komei Shirabe, Shoichi Toda, Ryo Atsuta, Shouichi Ohga, Shunji Tags: ORIGINAL RESEARCH Source Type: research

Efficacy of canakinumab in mild or severe COVID ‐19 pneumonia
ConclusionIn hospitalized adult patients with mild or severe non ICU COVID ‐19, canakinumab could be a valid therapeutic option. Canakinumab therapy causes rapid and long‐lasting improvement in oxygenation levels in the absence of any severe adverse events. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 19, 2021 Category: Allergy & Immunology Authors: Falasca Katia, Di Penta Myriam, Claudio Ucciferri, Antonio Auricchio, Marta Di Nicola, Michele Marchioni, Celletti Eleonora, Sabatini Emanuela, Francesco Cipollone, Jacopo Vecchiet Tags: ORIGINAL RESEARCH Source Type: research

Disease ‐duration based comparison of subsets of immune cells in SARS CoV‐2 infected patients presenting with mild or severe symptoms identifies prognostic markers for severity
ConclusionDisease severity was found to be associated with impaired maturation of mDCs and hyperactivation of NK, follicular T helper cells, and CD8 T cells. Lower IL ‐21 receptor expression on memory B cells indicated an imbalance in IL‐21/IL‐21 R ratio. Lower BCMA positive plasmablast cells in severe cases did suggest a probable absence of long‐term humoral immunity. Multivariate analysis revealed a progressive association of PD‐1+CD4 T cells with PRN T50 titers. Thus, in addition to identifying probable prognostic markers for severity, our study emphasizes the definite need for in ‐depth viral antigen‐spec...
Source: Immunity, Inflammation and Disease - January 16, 2021 Category: Allergy & Immunology Authors: Archana Kulkarni ‐Munje, Sonali Palkar, Shubham Shrivastava, Sanjay Lalwani, Akhilesh C. Mishra, Vidya A. Arankalle Tags: ORIGINAL RESEARCH Source Type: research

Clinical efficacy and safety of omalizumab in conventional treatment ‐resistant vernal keratoconjunctivitis: Our experience and literature review
Immunity, Inflammation and Disease, EarlyView. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 12, 2021 Category: Allergy & Immunology Authors: Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Gian Luigi Marseglia, Amelia Licari, Salvatore Leonardi Tags: EDITORIAL Source Type: research

RNA m6A methylation regulates virus –host interaction and EBNA2 expression during Epstein–Barr virus infection
ConclusionsThese results reveal the  critical role of m6A modification in the process of de novo EBV infection. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 12, 2021 Category: Allergy & Immunology Authors: Xiang Zheng, Jia Wang, Xiaoyue Zhang, Yuxin Fu, Qiu Peng, Jianhong Lu, Lingyu Wei, Zhengshuo Li, Can Liu, Yangge Wu, Qun Yan, Jian Ma Tags: ORIGINAL RESEARCH Source Type: research

Establishment and characterization of murine models of asthma and subcutaneous immunotherapy for Humulus pollen allergy
ConclusionsThe SC route can be used to establish a murine model ofHumulus pollen allergy that recapitulates the characteristics of clinical allergic asthma. Short ‐term SCIT can significantly improve symptoms and pathophysiology in asthmatic mice. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 12, 2021 Category: Allergy & Immunology Authors: Guang P. Xi, Qian Zhang, Jia Yin Tags: ORIGINAL RESEARCH Source Type: research

Serum soluble PD ‐1 plays a role in predicting infection complications in patients with acute pancreatitis
ConclusionSerum sPD ‐1/sPD‐L1 may be involved in the immunosuppressive process in AP. Moreover, the serum sPD‐1 level may be an independent risk factor for predicting ICs in AP patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 8, 2021 Category: Allergy & Immunology Authors: Xingxing Yu, Yu Pan, Qinglin Fei, Xianchao Lin, Zhijiang Chen, Heguang Huang Tags: ORIGINAL RESEARCH Source Type: research

Factors affecting upper airway control of NSAID ‐exacerbated respiratory disease: A real‐world study of 167 patients
ConclusionsNasal polyp eosinophilia, baseline OCS, and a history of recurrent ESS predict uncontrolled N ‐ERD. These factors might be clinically useful in risk‐estimation of uncontrolled disease and for organizing follow‐ups. Prospective cohort studies with larger sample size are needed to further study the factors affecting the upper airway control of N‐ERD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 5, 2021 Category: Allergy & Immunology Authors: Annina Lyly, Anu Laulajainen ‐Hongisto, Heikki Turpeinen, Seija I. Vento, Jyri Myller, Jura Numminen, Saara Sillanpää, Johanna Sahlman, Paula Kauppi, Sanna Toppila‐Salmi Tags: ORIGINAL RESEARCH Source Type: research

Systemic immune responses in patients with early localized or early disseminated Borrelia afzelii lyme borreliosis
ConclusionNo significant differences in systemic immune responses represented by selected cytokines or chemokines in serum samples of patients with EM infected withB. afzelii suggest that systemic mediators are not pivotal in the pathogenesis of dissemination of early infection in the form of MEM or LB ‐associated symptoms. Localized immune responses in the skin or other pathogenetic mechanisms may be more important in this regard. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 31, 2020 Category: Allergy & Immunology Authors: Tja ša Cerar Kišek, Rok Blagus, Eva Ružić‐Sabljić, Stefan Collinet‐Adler, Fajko F. Bajrović, Daša Stupica Tags: ORIGINAL RESEARCH Source Type: research

Serum proteome ‐wide identified ATP citrate lyase as a novel informative diagnostic and prognostic biomarker in pediatric sepsis: A pilot study
ConclusionsACLY is firstly identified in sera of patients with sepsis. Serum ACLY level is an additional diagnostic and prognostic biomarker in pediatric patients with sepsis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 30, 2020 Category: Allergy & Immunology Authors: Chunxia Wang, Xiaodong Zhu, Yun Cui, Huijie Miao, Yaya Xu, Xi Xiong, Xiaomeng Tang, Lujing Shao, Yucai Zhang Tags: ORIGINAL RESEARCH Source Type: research

Development of improved method to identify and analyze lung fibrocytes with flow cytometry in a reporter mouse strain
ConclusionOur findings suggest that the improved method can be a useful for the detection of pure lung fibrocytes and allows us to further analyze the characteristics of viable fibrocytes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 24, 2020 Category: Allergy & Immunology Authors: Hiroshi Kawano, Kazuya Koyama, Haruka Nishimura, Yuko Toyoda, Kozo Kagawa, Seidai Sato, Nobuhito Naito, Hisatsugu Goto, Yutaka Inagaki, Yasuhiko Nishioka Tags: ORIGINAL RESEARCH Source Type: research

Separate signaling events control TCR downregulation and T cell activation in primary human T cells
ConclusionsThese data suggest that there is substantial redundancy in the contribution of individual tyrosine kinases to TCR downregulation in primary human T cells. Our results highlight that TCR downregulation and T cell activation are controlled by different signaling events and illustrate the need for further research to untangle these processes. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 22, 2020 Category: Allergy & Immunology Authors: Lieve E. H. Donk, Louis S. Ates, Jet Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. Heijst Tags: ORIGINAL RESEARCH Source Type: research

Does COVID ‐19 contribute to development of neurological disease?
ConclusionThis review correlates present clinical manifestations of COVID ‐19 patients with possible neurological consequences in the future, thus preparing healthcare providers for possible future consequences of COVID‐19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Shasthara Paneyala, Duraisamy Patteswari, Meena Kishore Sakharkar, Hamdan Hamdan, David M. Ojcius, Srinivasa Rao Bolla, Musthafa Mohamed Essa, Saravana Babu Chidambaram, M. Walid Tags: REVIEW Source Type: research

Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease
This study focuses on the effects of obesity‐induced inflammations, which are the underlying causes of the disease progression and development of more severe inflammatory and fibrotic stages. Understanding the relationship between obesity a nd NAFLD could help in establishing attractive therapeutic targets or diagnostic markers in obesity‐induced inflammation response and provides new approaches for the prevention and treatment of NAFLD in obesity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Yunfei Luo, Hui Lin Tags: REVIEW Source Type: research

MicroRNA ‐425‐3p inhibits myocardial inflammation and cardiomyocyte apoptosis in mice with viral myocarditis through targeting TGF‐β1
The left ventricular function in mice was assessed by the observation of transthoracic echocardiography (Figure 1A ‐E): CVB3‐induced viral myocarditis presented elevated LVEDd and LVESd and reduced LVEF and LVFS. HE staining observation showed that on the 7th day after CVB3 infection, increased number of inflammatory cell infiltration (Figure 1G) and higher pathological score of myocardial tissues (Figure 1H ) were found in mice with CVB3‐induced viral myocarditis. Then we detected that miR‐425‐3p was downregulated in mice with CVB3‐induced viral myocarditis (Figure 1I,P
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Junhua Li, Jiehong Tu, Hong Gao, Lu Tang Tags: ORIGINAL RESEARCH Source Type: research

Sex discrepancy in the reduction of mucosal ‐associated invariant T cells caused by obesity
ConclusionOur study suggests that there is a sex discrepancy in the impact of obesity on MAIT cells: MAIT cells in male (but not female) humans and male mice are reduced by obesity. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Jianyun Liu, Hongmei Nan, Randy R Brutkiewicz, Jose Casasnovas, Kok Lim Kua Tags: ORIGINAL RESEARCH Source Type: research

The BTLA and PD ‐1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells
ConclusionThese results suggest that BTLA signaling is crucial in regulating γδ T cell proliferation and function and that the BTLA and PD‐1 signaling pathways act independently on the proliferation and cytotoxicity of human peripheral γδ T cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Hyun J. Hwang, Jae J. Lee, Sung H. Kang, Jin K. Suh, Eun S. Choi, Seongsoo Jang, Sang ‐Hyun Hwang, Kyung‐Nam Koh, Ho J. Im, Nayoung Kim Tags: ORIGINAL RESEARCH Source Type: research

miR ‐223 improves intestinal inflammation through inhibiting the IL‐6/STAT3 signaling pathway in dextran sodium sulfate‐induced experimental colitis
ConclusionsThe upregulation of miR ‐223 by agomir administration alleviated colonic inflammation in a DSS‐induced colitis model, which was likely mediated by inhibiting the production of pro‐inflammatory cytokines via the IL‐6/STAT3 signaling pathway. These findings provide evidence that miR‐223 might have potential therape utic implications in IBD. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 17, 2020 Category: Allergy & Immunology Authors: Juanjuan Zhang, Chenyang Wang, Zhen Guo, Binlin Da, Weiming Zhu, Qiurong Li Tags: ORIGINAL RESEARCH Source Type: research

Evidence and implications of pre ‐existing humoral cross‐reactive immunity to SARS‐CoV‐2
ConclusionAlthough the clinical relevance of the observed reactivity can only be speculated and needs to be investigated, the implication of this finding for coronavirus disease 2019 seroepidemiological survey and vaccines' clinical trials is critical. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 15, 2020 Category: Allergy & Immunology Authors: Amandine Mveang Nzoghe, Paulin N. Essone, Marielle Leboueny, Anicet Christel Maloupazoa Siawaya, Eliode Cyrien Bongho, Ofilia Mvoundza Ndjindji, Rotimi Myrabelle Avome Houechenou, Selidji Todagbe Agnandji, Joel Fleury Djoba Siawaya Tags: ORIGINAL RESEARCH Source Type: research

Association of a four ‐gene model with allergic diseases: Two‐year follow‐up of a birth cohort study
ConclusionThe gene model was significantly associated with the development of eczema in Chinese Han toddlers. Long ‐term follow‐up along with functional and replication studies on the gene model are still needed in future. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 5, 2020 Category: Allergy & Immunology Authors: Li Hua, Fen Yang, Qian Chen, Quanhua Liu, Ruoxu Ji, Haipei Liu, Jianmin Ye, Jun Zhang, Jianhua Zhang, Yixiao Bao Tags: ORIGINAL RESEARCH Source Type: research

Prognostic value of lipid metabolism ‐related genes in head and neck squamous cell carcinoma
Lipid metabolism ‐related genes effectively predicts head and neck squamous cell carcinoma (HNSCC) prognosis and reflects the state of immune cell in HNSCC. AbstractBackgroundAltered lipid metabolism is involved in the development of many tumors. However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma (HNSCC) is not fully established.AimsHere, we sought to determine the prognostic value of lipid metabolism ‐related genes in HNSCC.MethodsRNA ‐seq data and clinical features of 545 HNSCC cases were obtained from The Cancer Genome Atlas database. A regulatory network of transcription fac...
Source: Immunity, Inflammation and Disease - December 5, 2020 Category: Allergy & Immunology Authors: Ying Xiong, Yu Si, Yisi Feng, Shipei Zhuo, Bozhen Cui, Zhigang Zhang Tags: ORIGINAL RESEARCH Source Type: research

Silenced SOX2 ‐OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR‐2355‐3p
ConclusionsSilencing SOX2 ‐OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR‐2355‐3p. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 3, 2020 Category: Allergy & Immunology Authors: Yuming Liang, Boqun Wang, Huijuan Huang, Maoyun Wang, Qianwen Wu, Yaxin Zhao, Yan He Tags: ORIGINAL RESEARCH Source Type: research

Dec2 attenuates autophagy in inflamed periodontal tissues
ConclusionsThese results demonstrate that a Dec2 deficiency can alleviate LPS ‐induced inflammation via the ERK/mTOR signaling pathway by regulating autophagy, conceivably delivering a novel approach for the detection of periodontal treatments. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 3, 2020 Category: Allergy & Immunology Authors: Shunichi Oka, Xiaoyan Li, Fuyuki Sato, Fengzhu Zhang, Nitesh Tewari, Chongchong Chen, Liangjun Zhong, Makoto Makishima, Yi Liu, Ujjal K. Bhawal Tags: ORIGINAL RESEARCH Source Type: research

Eradication of hepatitis C virus infection in kidney transplant recipients using direct ‐acting antiviral therapy: Qatar experience
ConclusionsHCV infection was successfully eradicated by DAA therapy in kidney transplant recipients, with a 100% SVR rate. Moreover, DAA therapy was well ‐tolerated, and kidney function remained stable without an increased risk of rejection. These results are expected to drive the eradication of hepatitis C from the entire country. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - December 2, 2020 Category: Allergy & Immunology Authors: Mohamad M. Alkadi, Essa A. Abuhelaiqa, Mostafa F. Elshirbeny, Ahmed F. Hamdi, Omar M. Fituri, Muhammad Asim, Saad R. Alkaabi, Moutaz F. Derbala, Mona E. Jarman, Adel M. Ashour, Awais Nauman, Yousuf K. Al Maslamani, Adeel A. Butt, Hassan A. Al Tags: ORIGINAL RESEARCH Source Type: research

Rhinovirus remains prevalent in school teenagers during fight against COVID ‐19 pandemic
Immunity, Inflammation and Disease, EarlyView. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 28, 2020 Category: Allergy & Immunology Authors: Di Wu, Jianyun Lu, Zhangyu Sun, Lan Cao, Qing Zeng, Qun Liu, Tiantian Wu, Zhicong Yang Tags: COMMENTARY Source Type: research

Safety of hydroxychloroquine for treatment or prevention of SARS ‐CoV‐2 infection: A rapid systematic review and meta‐analysis of randomized clinical trials
ConclusionSafety profile of HCQ appears to be unsatisfactory when used to treat or prevent COVID ‐19, especially in the light of unproved clinical benefit. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 26, 2020 Category: Allergy & Immunology Authors: Alberto Enrico Maraolo, Adriano Grossi Tags: REVIEW Source Type: research

Impaired interferon ‐α expression in plasmacytoid dendritic cells in asthma
ConclusionOur study discovered the response to TLR ‐7 stimulation in pDCs was compromised and the sustainability of interferon‐α expression to RV stimulation was reduced in pDCs of asthmatic patients, which provide further evidence of defective innate response and subspeciality to RV infection in asthma. The high exacerbation history founded in RV+ patients agrees with these findings. Further research is required for the modulatory effect of IL‐4 on TLR‐7 stimulated pDCs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 25, 2020 Category: Allergy & Immunology Authors: Ting ‐Yu Lin, Chun‐Yu Lo, Kuo‐Chien Tsao, Po‐Jui Chang, Chih‐His Scott Kuo, Yu‐Lun Lo, Shu‐Min Lin, Meng‐Heng Hsieh, Tsai‐Yu Wang, Ping‐Chih Hsu, Horng‐Chyuan Lin Tags: ORIGINAL RESEARCH Source Type: research

Enhanced IgG1 ‐mediated antibody response towards thymus‐dependent immunization in CXCR1‐deficient mice
ConclusionOur data demonstrate a previously unknown relevance of CXCR1 for the production of specific IgG1 in response to vaccination. These findings identify CXCR1 as a promising candidate for future studies on the regulation of adaptive antibody responses. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 23, 2020 Category: Allergy & Immunology Authors: Jennifer Jaufmann, Melanie Carevic, Leyla T ümen, Derya Eliacik, Fee Schmitt, Dominik Hartl, Sandra Beer‐Hammer Tags: ORIGINAL RESEARCH Source Type: research

Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis
ConclusionsUnderstanding natural dynamics of CRS ‐associated tissues is essential to provide baseline context for all studies on putative biomarkers, mechanisms, and subtypes of CRS. These data further our understanding of the natural dynamics within nasal polypoid tissue, as well as local changes in response to systemic corticosteroid therapy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 21, 2020 Category: Allergy & Immunology Authors: Michael Hoggard, Bincy Jacob, David Wheeler, Melissa Zoing, Kevin Chang, Kristi Biswas, Martin Middleditch, Richard G. Douglas, Michael W. Taylor Tags: ORIGINAL RESEARCH Source Type: research

Animal models of rheumatoid arthritis ‐associated interstitial lung disease
ConclusionThese established animal models of the disease can significantly progress our understanding of the etiology of RA ‐ILD, the fundamental mechanisms of its pathogenesis and the identification of new bio‐markers, and can contribute to the development and implementation of novel treatment strategies. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 20, 2020 Category: Allergy & Immunology Authors: Li Xiong, Liang Xiong, Hong Ye, Wan ‐Li Ma Tags: REVIEW Source Type: research

Allergy protection at farms —just a myth?
Immunity, Inflammation and Disease, EarlyView. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 17, 2020 Category: Allergy & Immunology Authors: Matthias Wjst Tags: COMMENTARY Source Type: research

Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer
ConclusionOur study validates CEP55 as a potential diagnostic and prognostic biomarker for CRC, and we also provide multiple genes and potential molecular mechanisms that may serve as diagnostic and prognostic markers for CRC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 15, 2020 Category: Allergy & Immunology Authors: Kang Lin, Xiaojian Zhu, Chen Luo, Fanqin Bu, Jinfeng Zhu, Zhengming Zhu Tags: ORIGINAL RESEARCH Source Type: research

Five immune ‐gene‐signatures participate in the development and pathogenesis of Kawasaki disease
ConclusionOur study shows that we can distinguish normal samples from Kawasaki disease samples based on the infiltration of immune cells, and that CXCL8, CCL5, CCR7, CXCR3, and CCR1 may play important roles in the development of Kawasaki disease. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 14, 2020 Category: Allergy & Immunology Authors: Han Nie, Shizhi Wang, Quanli Wu, Danni Xue, Weimin Zhou Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Immunity, Inflammation and Disease, Volume 8, Issue 4, Page 481-482, December 2020. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 10, 2020 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

MicroRNA ‐378a‐3p contributes to ovarian cancer progression through downregulating PDIA4
ConclusionThis study provides evidences that miR ‐378a‐3p activates PI3K/AKT signaling pathway by modulating PDIA4 expression, thereby playing a role in promoting the growth of ovarian cancer cells. This study provides novel directions for targeted therapy of ovarian cancer. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 7, 2020 Category: Allergy & Immunology Authors: Yao Chanjiao, Chen Chunyan, Qiu Xiaoxin, Han Youjian Tags: ORIGINAL RESEARCH Source Type: research

Secreted TRAIL gene ‐modified adipose‐derived stem cells exhibited potent tumor‐suppressive effect in hepatocellular carcinoma cells
ConclusionTRAIL modified ADSCs can migrate towards HCC cells to inhibit tumor growth and the metastasis of implanted HCC tumors, which hints TRAIL modified ADSCs may be a new therapeutic approach for HCC treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 6, 2020 Category: Allergy & Immunology Authors: Zhuo Liu, Shaojie Li, Tiexiang Ma, Jian Zeng, Xin Zhou, Huanyu Li, Min Tang, Xiang Liu, Feng Li, Bin Jiang, Ming Zhao, Ying Chen Tags: ORIGINAL RESEARCH Source Type: research

Plasma cytomegalovirus DNA load predicts outcomes in liver transplant recipients
We described that high DNA replication (164 IU/ml) is an indicator of developing major postliver transplant complications. Implementing preemptive treatment for this high ‐risk group is mandatory to improve outcomes after liver transplantation. AbstractObjectiveCytomegalovirus (CMV) infection has a significant negative impact on liver transplant (LT) recipients. We aimed to evaluate the efficacy of real ‐time DNA quantitative polymerase chain reaction (qPCR) in the early detection of CMV and predicting post‐transplant outcomes.Materials and MethodsThis was a retrospective study that enrolled a total of 49 adult LT re...
Source: Immunity, Inflammation and Disease - November 3, 2020 Category: Allergy & Immunology Authors: Hao ‐Chien Hung, Po‐Jung Hsu, Jin‐Chiao Lee, Yu‐Chao Wang, Chih‐Hsien Cheng, Tsung‐Han Wu, Ting‐Jung Wu, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee, Chen‐Fang Lee Tags: ORIGINAL RESEARCH Source Type: research

The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
ConclusionsHMGB1 plays an important role in a variety of pediatric diseases and may be used as a diagnostic biomarker and therapeutic target for new strategies for the prevention and treatment of pediatric diseases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 2, 2020 Category: Allergy & Immunology Authors: Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le Tags: REVIEW Source Type: research

Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A
ConclusionsThese results demonstrated that SptP plays an essential role in the pathogenicity ofSalmonella Paratyphi A, andSalmonella Paratyphi A lackingsptP is immunogenic and protective in mice. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - November 1, 2020 Category: Allergy & Immunology Authors: Pengtao Pan, Fanyu Zou, Chuanshan He, Qunli He, Junlei Yin Tags: ORIGINAL RESEARCH Source Type: research

A signature of 18 immune ‐related gene pairs to predict the prognosis of pancreatic cancer patients
In our study, we aimed to construct an immune ‐related gene pairs (IRGPs) signature to predict the prognosis of pancreatic cancer patients. We will verify the validity of our model by receiver operating characteristic curve, prognostic analysis, multivariate and univariate Cox proportional‐hazards analysis, and infiltration of different imm une cells. Unlike traditional model, the pairwise comparison of each IRGP and the calculation of the score were absolutely based on the genetic expressions in the same patient thus it is not a necessity in our IRGPs signature to standardize the genetic expression profiles from diffe...
Source: Immunity, Inflammation and Disease - October 31, 2020 Category: Allergy & Immunology Authors: Fanqin Bu, Han Nie, Xiaojian Zhu, Ting Wu, Kang Lin, Jiefeng Zhao, Jun Huang Tags: ORIGINAL RESEARCH Source Type: research

Cesarean section and risk of allergies in Ecuadorian children: A cross ‐sectional study
ConclusionsAs seen in industrialized settings, children born by CS in nonindustrialized countries have an increased risk of developing allergic disorders including asthma and dermatitis, compared to those delivered vaginally. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 30, 2020 Category: Allergy & Immunology Authors: Am élie Gorris, Gabriela Bustamante, Katharina A. Mayer, Tamar Kinaciyan, Gerhard J. Zlabinger Tags: ORIGINAL RESEARCH Source Type: research

Transcriptomic analysis reveals novel mechanisms of SARS ‐CoV‐2 infection in human lung cells
AbstractBackgroundSevere acute respiratory syndrome coronavirus clade 2 (SARS ‐CoV‐2) is a single‐stranded RNA virus responsible for the global pandemic of the coronavirus disease‐2019 (COVID‐19). To date, there are still no effective approaches for the prevention and treatment of COVID‐19.ObjectiveThe present study aims to explore the possible mechanisms of SARS ‐CoV‐2 infection in human lung cells.MethodsData interpretation was conducted by recruiting bioinformatics analysis, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways analysis using downloaded data from the NCBI Gene Expr...
Source: Immunity, Inflammation and Disease - October 30, 2020 Category: Allergy & Immunology Authors: Shaomin Yang, Songbin Wu, Zhijian Yu, Jiabin Huang, Xia Zhong, Xiaodong Liu, Hua Zhu, Lizu Xiao, Qiwen Deng, Wuping Sun Tags: ORIGINAL RESEARCH Source Type: research

SLy2 ‐deficiency promotes B‐1 cell immunity and triggers enhanced production of IgM and IgG2 antibodies against pneumococcal vaccine
ConclusionOur results reveal reinforced specific antibody responses towards pneumococcal polysaccharides and enhanced IgG2 secretion as a consequence of SLy2 deficiency, which could be relevant to the development of more efficient vaccines. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 24, 2020 Category: Allergy & Immunology Authors: Jennifer Jaufmann, Leyla T ümen, Fee Schmitt, Daniel Schäll, Max Holleben, Sandra Beer‐Hammer Tags: ORIGINAL RESEARCH Source Type: research

Low dose IL ‐2 suppress osteoclastogenesis in collagen‐induced arthritis via JNK dependent pathway
ConclusionIt is the first time for us to prove that low dose IL ‐2 can inhibit osteoclast formation in collagen‐induced arthritis through the JNK dependent pathway, which will provide the angle and theoretical basis for future immunotherapy of IL‐2. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 24, 2020 Category: Allergy & Immunology Authors: Han Sun, Yong Zhao, Kun Wang, Li Zhu, Jian Dong, Jie Zhao, Yimin Wang, Huan Li, Xiaoliang Sun, Yunjie Lu Tags: ORIGINAL RESEARCH Source Type: research

What has single ‐cell RNA sequencing revealed about microglial neuroimmunology?
Single ‐cell RNA sequencing (scRNA‐seq) reveals that microglia vary by age, brain regions, and by disease. However, scRNA‐seq is still facing challenges the biggest of which is sequencing costs AbstractThe use of single ‐cell RNA sequencing (scRNA‐seq) in microglial research is increasing rapidly. The basic workflow of this approach consists of isolating single cells, followed by sequencing. scRNA‐seq is capable of examining microglial heterogeneity on a cellular level. However, the results gained from applyi ng this technique suffer from discrepancies due to differences between applied methods characteristics ...
Source: Immunity, Inflammation and Disease - October 21, 2020 Category: Allergy & Immunology Authors: Norwin Kubick, Patrick C. Henckell Flournoy, Pavel Klimovich, Gina Manda, Michel ‐Edwar Mickael Tags: REVIEW Source Type: research

Harnessing noncoding RNA ‐based macrophage polarization: Emerging therapeutic opportunities for fibrosis
ConclusionsA broader understanding of how ncRNA ‐directed macrophage phenotype transition in immunity and fibrosis might promote the development of a novel strategy for antifibrotic treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 20, 2020 Category: Allergy & Immunology Authors: Dexi Zhou, Yilai Wu, Sheng Wang, Jun Li, Jiajie Luan Tags: REVIEW Source Type: research

Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma
ConclusionsIn addition to NFATc1 and NIP45, NFATc2 was found upregulated in asthma. Moreover, NFATc1 mRNA correlated with lymphocytes both in control and asthma, and NFATC1 and NFATc2 mRNA showed a direct correlation with eosinophils in controls but not in asthma, indicating that NFATc1 is associated with lymphocytes and not eosinophils in asthma.Clinical SignificanceTargeting NFATc2 in T lymphocytes might ameliorate the allergic phenotype in asthmatic subjects. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 20, 2020 Category: Allergy & Immunology Authors: Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto Tags: ORIGINAL RESEARCH Source Type: research

Association between HLA gene polymorphisms and mortality of COVID ‐19: An in silico analysis
ConclusionThis study suggests that individuals with HLA ‐A*11:01 or HLA‐A*24:02 genotypes may generate efficiently T‐cell‐mediated antiviral responses to SARS‐CoV‐2 compared with HLA‐A*02:01. The differences in HLA genotypes may potentially alter the course of the disease and its transmission. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - October 13, 2020 Category: Allergy & Immunology Authors: Yusuke Tomita, Tokunori Ikeda, Ryo Sato, Takuro Sakagami Tags: ORIGINAL RESEARCH Source Type: research