The increasing incidence and prevalence of hypereosinophilic syndrome in the United Kingdom
ConclusionThese results provide estimates of the burden of HES in the United Kingdom and indicate that whilst HES is a very rare disease, there is evidence that is increasingly being recorded in UK primary care. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 23, 2021 Category: Allergy & Immunology Authors: Gema Requena, John Logie, Daniel C. Gibbons, Jonathan Steinfeld, Melissa K. Van Dyke Tags: ORIGINAL ARTICLE Source Type: research

Are hematopoietic cell transplant recipients with Gram ‐negative bacteremia spending more time outpatient while on intravenous antibiotics? Addressing trends over 10 years at a single center
ConclusionThese results suggest that, despite increased availability of outpatient suitable treatment options, allogeneic HCT recipients with GNRBs received less treatment in outpatient settings. However, among patients with similar posttransplant complications, the lack of significant decline suggests that treatment location decisions remained consistent for patients with similar posttransplant complications. These findings suggest the need for additional interventions targeting outpatient antibiotic treatment among allogeneic HCT recipients with GNRBs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 22, 2021 Category: Allergy & Immunology Authors: Margaret L. Lind, Steven Roncaioli, Catherine Liu, Andrew Bryan, Ania Sweet, Frank Tverdek, Mohamed Sorror, Amanda I. Phipps, Steven A. Pergam Tags: SHORT REPORT Source Type: research

High ‐resolution HLA genotyping identifies alleles associated with severe COVID‐19: A preliminary study from India
ConclusionGenotyping for these alleles will enable identification of individuals at risk of severe disease and stratification for preferential vaccination. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 21, 2021 Category: Allergy & Immunology Authors: Ravikanth Vishnubhotla, Mitnala Sasikala, Vijayasarathy Ketavarapu, Duvvur Nageshwar Reddy Tags: SHORT REPORT Source Type: research

Characterization of the blood and neutrophil ‐specific microbiomes and exploration of potential bacterial biomarkers for sepsis in surgical patients
ConclusionsWe present evidence identifying significant changes of blood and neutrophil-specific microbiomes across various stages of sepsis, which might be associated with the progression of sepsis after surgical treatments. Several certain bacterial genera in blood microbiome could have potential as microbial markers for early detection of sepsis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 21, 2021 Category: Allergy & Immunology Authors: Chenyang Wang, Qiurong Li, Chun Tang, Xiaofan Zhao, Qin He, Xingming Tang, Jianan Ren Tags: ORIGINAL ARTICLE Source Type: research

Neutrophil extracellular traps induce a hypercoagulable state in glioma
ConclusionsOur results showed the interaction between NETs and hypercoagulability in glioma patients. Targeting NETs may be a potential therapeutic and prevention direction for thrombotic complications in glioma patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 19, 2021 Category: Allergy & Immunology Authors: Shihua Zhang, Mengfan Guo, Qianzi Liu, Jingfeng Liu, Yankun Cui Tags: ORIGINAL ARTICLE Source Type: research

ORMDL3 overexpression facilitates Fc εRI‐mediated transcription of proinflammatory cytokines and thapsigargin‐mediated PERK phosphorylation in RBL‐2H3 cells
ConclusionsOur findings suggest that ORMDL3 plays an important role in regulating proinflammatory cytokine expression via the S1P pathway and selectively affects the UPR pathway in mast cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 19, 2021 Category: Allergy & Immunology Authors: Kazuhiro Ogi, Tetsuji Takabayashi, Kaori Tomita, Masafumi Sakashita, Taiyo Morikawa, Takahiro Ninomiya, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda Tags: ORIGINAL ARTICLE Source Type: research

Upcoming treatments for morphea
Morphea is a rare connective tissue disease with variable clinical presentations, all of which are characterized by inflammatory fibrosis. No cure for morphea exists, but advances in our understanding of the mediators and cellular pathways underlying fibrosis have revealed potential therapeutic targets. Here, we review the upcoming treatments for morphea and other related inflammatory fibrosing disorders, focusing on anti-inflammatory, antifibrotic, and senolytics approaches. AbstractMorphea (localized scleroderma) is a rare autoimmune connective tissue disease with variable clinical presentations, with an annual incidence...
Source: Immunity, Inflammation and Disease - July 18, 2021 Category: Allergy & Immunology Authors: Dan Wenzel, Nazgol ‐Sadat Haddadi, Khashayar Afshari, Jillian M. Richmond, Mehdi Rashighi Tags: REVIEW ARTICLE Source Type: research

The prognostic value of myocardial injury in COVID ‐19 patients and associated characteristics
COVID patients with myocardial injury on admission is associated with more severe clinical presentation and biomarkers. Myocardial injury (hazard ratio  = 4.55;p 
Source: Immunity, Inflammation and Disease - July 10, 2021 Category: Allergy & Immunology Authors: Jian He, Bicheng Zhang, Quan Zhou, Wenjing Yang, Jing Xu, Tingting Liu, Haijun Zhang, Zhiyong Wu, Dong Li, Qing Zhou, Jie Yan, Cuizhen Zhang, Haiyan Qian, Minjie Lu, Xiaoyang Zhou Tags: ORIGINAL ARTICLE Source Type: research

Serum triglyceride levels and related factors as prognostic indicators in COVID ‐19 patients: A retrospective study
The objective of this study was to explore the relationship between TG levels and prognosis in COVID-19 patients and investigate the factors that affect TG. COVID-19 patients were divided into normal or high TG level groups. Their demographic data, medical history, signs and symptoms, laboratory results, and final clinical results were analyzed retrospectively. A total of 174 patients were included. TG level was 1.6 (interquartile range [IQR]: 1.1 ‒2.1) mmol/L for all patients; 2.2 (IQR: 1.8‒2.7) mmol/L and 1.1 (IQR: 1.0–1.3) mmol/L in the high TG and control groups, respectively. Overall, 29...
Source: Immunity, Inflammation and Disease - July 8, 2021 Category: Allergy & Immunology Authors: Peng Zhong, Zhenzhou Wang, Zhe Du Tags: ORIGINAL ARTICLE Source Type: research

A macrophage attack culminating in microthromboses characterizes COVID 19 pneumonia
ConclusionsThree COVID-19 patients with evidence of a hyperactive immune response (elevated ferritin and acute phase proteins) defibrinated while blood levels of SFMC were being monitored. SFMC levels that were five times higher than normal appeared in the circulation during the defibrination process. SFMC at these levels may precipitate as showers of microclots, damaging heart, kidney, brain, and so forth. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 7, 2021 Category: Allergy & Immunology Authors: Brian S. Bull, Karen L. Hay Tags: ORIGINAL ARTICLE Source Type: research

Alcohol consumption induces murine osteoporosis by downregulation of natural killer T ‐like cell activity
ConclusionsOur results indicate that the inactivation of innate immune cells, APCs, and NKT-like cells are likely to be crucial for alcohol-induced osteoporosis and provide a new therapeutic approach for preventing osteoporosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - July 4, 2021 Category: Allergy & Immunology Authors: Munehiro Naruo, Yasuyuki Negishi, Takahisa Okuda, Midori Katsuyama, Ken Okazaki, Rimpei Morita Tags: ORIGINAL ARTICLE Source Type: research

Based on bioinformatics analysis lncrna SNHG5 modulates the function of vascular smooth muscle cells through mir ‐205‐5p/SMAD4 in abdominal aortic aneurysm
ConclusionBioinformatics were used to explore molecular mechanism of AAA progression. The findings of this study show that lncRNA SNHG5 regulates proliferation and apoptosis of VSMC cells through modulation of the mir-205-5p/SMAD4 axis. Therefore, SNHG5 is a potential therapeutic target for AAA disease. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 30, 2021 Category: Allergy & Immunology Authors: Han Nie, Wenpeng Zhao, Shizhi Wang, Weimin Zhou Tags: ORIGINAL ARTICLE Source Type: research

A novel anti ‐inflammatory treatment for bradykinin‐induced sore throat or pharyngitis
ConclusionThis study elucidates the complex mechanisms involved in healing pharyngitis, an inflammatory condition of the upper respiratory epithelia. An ASA-based formula (Biovanta) mitigated bradykinin-induced inflammation more strongly than ASA alone in organotypic human respiratory tissues. Surprisingly, we found that many of the most common over the counter sore throat therapies exacerbate inflammation and IL-8 in organotypic human respiratory tissues, suggesting these common treatments may increase the likelihood of further respiratory complications. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 22, 2021 Category: Allergy & Immunology Authors: Victor Leyva ‐Grado, Pavel Pugach, Nazlie Sadeghi‐Latefi Tags: ORIGINAL ARTICLE Source Type: research

Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma
ConclusionHaving pets at home is associated with AD and asthma in the offspring of mothers with asthma. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 19, 2021 Category: Allergy & Immunology Authors: Zarqa Ali, Gregor B.E. Jemec, Charlotte Suppli Ulrik Tags: ORIGINAL ARTICLE Source Type: research

Skin rashes after SARS ‐CoV‐2 vaccine: which relationship, if any?
  (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 19, 2021 Category: Allergy & Immunology Authors: Cataldo Patruno, Maddalena Napolitano, Luca Stingeni, Gabriella Fabbrocini Tags: COMMENTARY Source Type: research

CircZNF124 regulates cell proliferation, leucine uptake, migration and invasion by miR ‐199b‐5p/SLC7A5 pathway in endometrial cancer
ConclusionCircZNF124 depletion inhibited EC cell malignancy by miR-199b-5p/SLC7A5 pathway, which demonstrated that circZNF124 had the potential as a therapeutic target for EC. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 19, 2021 Category: Allergy & Immunology Authors: Liuping Shu, Yan Peng, Liyan Zhong, Xi Feng, Lifu Qiao, Yi Yi Tags: ORIGINAL ARTICLE Source Type: research

Cladophialophora bantiana and Nocardia farcinica infection simultaneously occurring in a kidney transplant recipient: Case report and literature review
We present the first reported renal transplant case withCladophialophora bantiana involving the renal allograft with concurrent invasive nocardiosis involving the lungs and brain. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 16, 2021 Category: Allergy & Immunology Authors: Pedro Cort és, D. Jane Hata, Claudia Libertin, Diana M. Meza Villegas, Dana M. Harris Tags: REVIEW ARTICLE Source Type: research

The influence of extracellular tissue on neutrophil function and its possible linkage to inflammatory diseases
Conclusion: Because of the high abundance of type III collagen in lung and skin matrices, the interaction of PMN with the respective matrix could be an important mechanism in the pathophysiology of acute respiratory distress syndrome and pyoderma gangrenosum. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 12, 2021 Category: Allergy & Immunology Authors: Richard F. Kraus, Michael A. Gruber, Martin Kieninger Tags: ORIGINAL ARTICLE Source Type: research

Relationship of transitional regulatory B and regulatory T cells and immunosuppressive drug doses in stable renal transplant recipients
ConclusionBregs appear to be insensitive to high doses of posttransplant immunosuppressive drugs. The protracted Breg decrease posttransplant might be caused by impaired T cell support attributable to immunosuppressive drugs. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 9, 2021 Category: Allergy & Immunology Authors: Eman H Ibrahim, Mostafa Aly, Christian Morath, Douaa M Sayed, Naruemol Ekpoom, Gerhard Opelz, Caner S üsal, Volker Daniel Tags: ORIGINAL ARTICLE Source Type: research

Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion
This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may influence the outcome of LIT.MethodsThis study included a total of 704 URSA patients, of which 444 patients accepted LIT treatment. URSA patients that did not accept LIT served as control group. Clinical characteristics were collected and analyzed between LIT and control group. The blocking antibody was tested before and after LIT. The outcome of LIT treatment was recorded. Logistic regression analysis was applied to evaluate the independent predictors of LIT success.ResultsAfter LIT treatment, 77.9% (346/444) o...
Source: Immunity, Inflammation and Disease - June 8, 2021 Category: Allergy & Immunology Authors: Sudong Liu, Xiaodong Gu, Ruiqiang Weng Tags: ORIGINAL ARTICLE Source Type: research

Feasible kidney donation with living marginal donors, including diabetes mellitus
This study demonstrates the safety and potential of kidney donations for marginal donors. Careful Mmarginal donors with diabetes mellitus selection has the potential to expand the donor pool. AbstractObjectivesTo compare the donor outcomes of living donor kidney transplantation between standard donors (SDs) and marginal donors (MDs) including diabetic patients (MD  + DM).MethodsMDs were defined according to Japanese guideline criteria: (a) age>70-years, (b) blood pressure ≤130/80 mmHg on hypertension medicine, (c) body mass index>25 to ≤32 kg/m2, (d) 24-h creatinine clearance ≥70 ...
Source: Immunity, Inflammation and Disease - June 8, 2021 Category: Allergy & Immunology Authors: Kasumi Yoshinaga, Motoo Araki, Koichiro Wada, Takanori Sekito, Shogo Watari, Yuki Maruyama, Yosuke Mitsui, Takuya Sadahira, Risa Kubota, Shingo Nishimura, Kohei Edamura, Yasuyuki Kobayashi, Katsuyuki Tanabe, Hidemi Takeuchi, Masashi Kitagawa Tags: ORIGINAL ARTICLE Source Type: research

Neutrophil extracellular traps induce thrombogenicity in severe carotid stenosis
ConclusionsThe current study revealed differences in the levels of NETs in the plasma of symptomatic and asymptomatic patients suffering from carotid stenosis. The study also uncovered the interaction between NETs and thrombogenicity in carotid stenosis. Therefore, inhibiting NETs may be a potential biomarker and therapeutic target for recurring stroke in severe carotid stenosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 8, 2021 Category: Allergy & Immunology Authors: Shihua Zhang, Mengfan Guo, Qianzi Liu, Jingfeng Liu, Yankun Cui Tags: ORIGINAL ARTICLE Source Type: research

Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF ‐κB signaling
ConclusionOur results suggested that USP14 promotes proinflammatory cytokine production through activation of NF- κB. Developing drugs targeting USP14 may be beneficial for the prevention or treatment of patients with preeclampsia. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 6, 2021 Category: Allergy & Immunology Authors: Yingzi Zhao, Fang Zong Tags: ORIGINAL ARTICLE Source Type: research

Cyclin ‐dependent kinase 1 shows to be a potential genetic target for chemical cystitis
ConclusionCdk1 might be a potential pathogenic genetic target for chemical cystitis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 3, 2021 Category: Allergy & Immunology Authors: Kun Wang, Huaping Du, Qianfeng Zhuang, Hao Lu, Renfang Xu, Dong Xue Tags: ORIGINAL ARTICLE Source Type: research

CCL17 ‐CCR4 axis contributes to the onset of vitiligo in mice
ConclusionTargeting CCL17-CCR4 axis might inhibit T cell migrating to skin and alleviate vitiligo progression. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: He Li, Congpin Wang, Xiaoqing Li, Yinghui Kong, Weiguo Sun Tags: ORIGINAL ARTICLE Source Type: research

Identification and validation of immune ‐related lncRNA prognostic signatures for melanoma
ConclusionThe immune-related lncRNA signature offers prognostic markers and potential immunotherapeutic targets for melanoma. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: Bo Xiao, Liyan Liu, Aoyu Li, Pingxiao Wang, Cheng Xiang, Hui Li, Tao Xiao Tags: ORIGINAL ARTICLE Source Type: research

Ferulic acid suppresses interleukin ‐1β‐induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC‐1α signaling pathway
ConclusionOur findings reveal that FA prevents IL-1 β-induced osteoarthritis chondrocyte toxicity, which suggests that FA may be a potential therapy for osteoarthritis and warrants further investigation for its clinical application. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: Kewei Du, Xuchen Fang, Ziqiang Li Tags: ORIGINAL ARTICLE Source Type: research

Long ‐coronavirus disease among people living with HIV in western India: An observational study
ConclusionLong-COVID is common among PLHIV with moderate –severe acute COVID-19 illness. There is a need for integration of long-COVID diagnosis and care services within antiretroviral therapy clinics for PLHIV with COVID-19. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: Sanjay Pujari, Sunil Gaikwad, Abhishek Chitalikar, Digamber Dabhade, Kedar Joshi, Vivek Bele Tags: ORIGINAL ARTICLE Source Type: research

Time ‐related variation in IgG subclass concentrations in a group of healthy Danish adults
ConclusionThe study documents that IgG or IgG subclass concentrations within healthy individuals are very stable over at least 42 weeks. The expected variation for IgG4 concentrations at a 95% confidence level does not exceed ±16.9%. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: Kristina Fruerlund Rasmussen, Ulrik Sprog øe, Christian Nielsen, Dana‐Bar Shalom, Kristian Assing Tags: ORIGINAL ARTICLE Source Type: research

Circ_HECW2 regulates LPS ‐induced apoptosis of chondrocytes via miR‐93 methylation
ConclusionIn summary, our data revealed that the Circ_HECW2 is highly expressed in OA and might inhibit miR-93 expression through methylation to affect LPS-induced chondrocyte apoptosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 2, 2021 Category: Allergy & Immunology Authors: Jianwei Zuo, Chen Chen, Xintao Zhang, Jiangyi Wu, Canfeng Li, Shuai Huang, Peiheng He, Qingde Wa, Wentao Zhang Tags: ORIGINAL ARTICLE Source Type: research

LncRNA linc00152/NF ‐κB feedback loop promotes fibroblast‐like synovial cells inflammation in rheumatoid arthritis via regulating miR‐103a/TAK1 axis and YY1 expression
Conclusion: Our data suggested that the linc00152/NF- κB feedback loop promotes RAFLS inflammation via regulating miR-103a/TAK1 axis and YY1 expression. Thus, linc00152 acts as a switch to control this regulatory circuit and may serve as a diagnostic and therapeutic target for RA treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 1, 2021 Category: Allergy & Immunology Authors: Jian Zhang, Fei ‐Fei Gao, Jie Xie Tags: ORIGINAL RESEARCH Source Type: research

Rigosertib inhibits MEK1 –ERK pathway and alleviates lipopolysaccharide‐induced sepsis
ConclusionIn contrast, the effects of rigosertib on sepsis were abrogated in septic MEK1DD mice, which had inducible constitutive activation of MEK1 signaling. Rigosertib alleviated LPS-induced sepsis inhibits MEK1/ERK signaling pathway. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - June 1, 2021 Category: Allergy & Immunology Authors: Yin Wang, Pengfei Du, Donghui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Tick salivary gland extract induces alpha ‐gal syndrome in alpha‐gal deficient mice
Alpha-gal syndrome (AGS) is characterized by delayed hypersensitivity to non-primate mammalian meat in people having specific IgE (sIgE) to the oligosaccharide galactose-alpha-1,3-galactose and has been linked to tick bites from Amblyomma americanum (Aa) in the U.S. We demonstrate that intradermal injection of Aa tick salivary gland extract (TSGE) in alpha-gal knockout (AGKO) mice induce alpha-gal sIgE production and mice displayed moderate clinical allergic signs along with a drop in core body temperature as an objective measure of a systemic allergic reaction. Further, this model recapitulates several aspects of red meat...
Source: Immunity, Inflammation and Disease - May 26, 2021 Category: Allergy & Immunology Authors: Shailesh K. Choudhary, Shahid Karim, Onyinye I. Iweala, Shivangi Choudhary, Gary Crispell, Surendra Raj Sharma, Claire T. Addison, Mike Kulis, Brian H. Herrin, Susan E. Little, Scott P. Commins Tags: ORIGINAL ARTICLE Source Type: research

Association between neutrophils and renal impairment of rheumatoid arthritis: A retrospective cross ‐sectional study
In this present study, neutrophil greater than 7.5  × 109/L may be associated with a high risk of renal impairment in RA. We also found that UA  >  360 μmol/L and hemoglobin less than 120 g/L independently associated with a higher risk of renal impairment in RA patients. Although more prospective studies are needed to verify our results, based on the above data, we believe that continuous monitoring of these risk factors in RA patients is necessary and it could be used for early detection and identification of changes in GFR, allowing doctors to treat patients with pote...
Source: Immunity, Inflammation and Disease - May 25, 2021 Category: Allergy & Immunology Authors: Pei ‐Dan Yang, Kai‐Jun Zhu, Si‐Min Lin, Zhi‐Xin Chen, Min‐Ying Liu, Qing‐Ping Liu, Chang‐Song Lin, Cong‐Qiu Chu, Qiang Xu Tags: ORIGINAL ARTICLE Source Type: research

The complex role of AIM2 in autoimmune diseases and cancers
Herein, we provide an overview of the emerging research progress on the function and regulatory pathway of absent in melanoma 2 (AIM2) in innate and adaptive immune cells, as well as tumor cells, and discuss its pathogenic role in autoimmune diseases, such as systemic lupus erythematosus, psoriasis, primary Sjogren's syndrome, and cancers, such as melanomas, non-small-cell lung cancer, colon cancer, hepatocellular carcinoma, renal carcinoma, and so on, hopefully providing potential therapeutic and diagnostic strategies for clinical use.​ AbstractAbsent in melanoma 2 (AIM2) is a novel member of interferon (IFN)-inducible ...
Source: Immunity, Inflammation and Disease - May 20, 2021 Category: Allergy & Immunology Authors: Huan Zhu, Ming Zhao, Christopher Chang, Vera Chan, Qianjin Lu, Haijing Wu Tags: REVIEW ARTICLE Source Type: research

Activation of the cGAS –STING signaling pathway in adenomyosis patients
In this study, we aimed to investigate whether the cGAS –STING pathway was activated and correlated with clinical outcomes in adenomyosis patients.Materials and MethodsTwenty patients diagnosed with adenomyosis and 10 patients diagnosed with cervical intraepithelial neoplasia grade 3 (CIN-3) but no adenomyosis were enrolled in this study. Specimens were collected during surgery from August 2017 to December 2017 at Third Xiangya Hospital. The messenger RNA (mRNA) and protein levels of key cGAS –STING pathway factors in uterine tissue were detected by real-time reverse-transcription polymerase chain reaction ...
Source: Immunity, Inflammation and Disease - May 19, 2021 Category: Allergy & Immunology Authors: Yun Lin, Luying Wang, Mingzhu Ye, Ke ‐nan Yu, Xin Sun, Min Xue, Xinliang Deng Tags: ORIGINAL ARTICLE Source Type: research

Polydatin has anti ‐inflammatory and antioxidant effects in LPS‐induced macrophages and improves DSS‐induced mice colitis
AbstractPolydatin (PD), a monocrystalline compound isolated from the root and rhizome ofPolygonum cuspidatum, is widely used in inhibiting the inflammatory response and oxidative stress. PD has an anti-inflammatory effect on colitis mice; however, information regulating the mechanism by which maintains the intestinal epithelium barrier is currently scarce. Here, we assessed the anti-inflammatory and antioxidant of PD in lipopolysaccharide (LPS)-induced macrophages in vitro, and explored its effects on inhibiting intestinal inflammation and maintaining the intestinal epithelium barrier in dextran sodium sulfate (DSS)-induce...
Source: Immunity, Inflammation and Disease - May 19, 2021 Category: Allergy & Immunology Authors: Guangxin Chen, Ziyue Yang, Da Wen, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang, Changxin Wu, Lina Dong Tags: ORIGINAL ARTICLE Source Type: research

Als3 ‐Th‐cell‐epitopes plus the novel combined adjuvants of CpG, MDP, and FIA synergistically enhanced the immune response of recombinant TRAP derived from Staphylococcus aureus in mice
ConclusionAls3 epitopes significantly enhanced TRAP immunogenicity. ATT plus the novel combined adjuvants of CpG, MDP, and FIA induced the strong immune response and protection againstS. aureus, revealing the combination of CpG, MDP, and FIA adjuvant acts the synergistic effect. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 19, 2021 Category: Allergy & Immunology Authors: Jinzhu Ma, Wei Liu, Beiyan Wang, Simiao Yu, Liquan Yu, Baifen Song, Yongzhong Yu, Zhanbo Zhu, Yudong Cui Tags: ORIGINAL ARTICLE Source Type: research

Early introduction oral immunotherapy for IgE ‐mediated cow's milk allergy: A follow‐up study confirms this approach as safe and appealing to parents
ConclusionsThis study confirmed the long-term safety of E-OIT for CMA and challenged the paradigm of the need for allergen food withdrawal to discern between desensitization and tolerance. It could be a starting point for planning future trials on this issue. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 18, 2021 Category: Allergy & Immunology Authors: Laura Badina, Laura Levantino, Valentina Carrato, Giulia Peruch, Fulvio Celsi, Egidio Barbi, Irene Berti, Giorgio Longo Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 17, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

A simple, sensitive, and low ‐cost FACS assay for detecting antibodies against the native SARS‐CoV‐2 spike protein
Conclusion: We conclude that high-titer CoV-2 S-specific antibodies are found in most recovered COVID-19 patients and in symptomatic contacts, but only rarely in asymptomatic contacts. The assay may help health care providers to monitor disease progression and antibody responses in vaccination trials, to identify health care personnel that likely are resistant to re-infection, and recovered individuals with high antibody titers that may be suitable asplasma and/or antibody donors. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 12, 2021 Category: Allergy & Immunology Authors: Julia Hambach, Tobias St ähler, Thomas Eden, Dorte Wendt, Natalie Tode, Friedrich Haag, Eva Tolosa, Marcus Altfeld, Anahita Fathi, Christine Dahlke, Marylyn M. Addo, Stephan Menzel, Friedrich Koch‐Nolte Tags: ORIGINAL ARTICLE Source Type: research

Comprehensive analysis of Syk gene methylation in colorectal cancer
Conclusions: ​ ​This study demonstrates that the expression of Syk could be restored by decitabine in colorectal cancer, thus affecting the migration and invasion abilities of CRC cells. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 12, 2021 Category: Allergy & Immunology Authors: Fanqin Bu, Xiaojian Zhu, Sicheng Liu, Kang Lin, Jinfeng Zhu, Jun Huang Tags: ORIGINAL ARTICLE Source Type: research

The first non ‐radiographic axial spondyloarthrits with COVID‐19
ConclusionMechanism of SARS-CoV-2 triggering autoimmunity is still unknown at this time. However, it is important that insights be gained into the type of disease that can be triggered by this infection. As the pandemic continues to rage on, Rheumatologist need to be increasing aware that patients presenting with various forms of inflammatory arthritis may be triggered by an antecedent SARS-CoV-2 infection. Following these cases may help to determine how they differ from other forms of inflammatory arthropathy. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 12, 2021 Category: Allergy & Immunology Authors: Wassim Saikali, Suzanne Gharib Tags: COMMENTARY Source Type: research

COVID ‐19 infection in CVID patients: What we know so far
ConclusionsCOVID-19 poses an elevated threat to CVID patients. However, only systematic studies can provide robust information on the extent of this threat. Regular immunoglobulin replacement therapy is beneficial to combat COVID-19 in CVID patients, and best treatment after infection includes the use of convalescent plasma in addition to common medication. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 12, 2021 Category: Allergy & Immunology Authors: Niels Weifenbach, Alisha Jung, Stefan L ötters Tags: COMMENTARY Source Type: research

Granulocyte colony ‐stimulating factor is not pathogenic in lupus nephritis
Graphical abstractLupus nephritis is perpetuated by unrestrained inflammation, potentially driven by the hematopoietic growth factor granulocyte colony-stimulating factor (G-CSF). Lupus-prone Lyn-deficient mice lacking G-CSF were not protected from the development of autoimmunity and, in fact, exhibited exacerbated indices of kidney pathology. Furthermore, G-CSF levels in human serum were not elevated in systemic lupus erythematosus patients or in correlation with renal disease, overall indicating that G-CSF is not a major pathogenic factor in lupus nephritis. AbstractSystemic lupus erythematosus (lupus) is an autoimmune d...
Source: Immunity, Inflammation and Disease - May 7, 2021 Category: Allergy & Immunology Authors: Timothy A. Gottschalk, Fabien B. Vincent, Alberta Y. Hoi, Margaret L. Hibbs Tags: ORIGINAL ARTICLE Source Type: research

Parameters associated with diagnosis of COVID ‐19 in emergency department
AbstractObjectivesWe designed this study to identify laboratory and radiological parameters, which could be useful to guide the clinician, in the evaluation of a suspected case of coronavirus disease 19 (COVID-19).MethodsThis retrospective, observational, single-center-study recruited patients with a suspect of COVID-19 data were extracted from electronic medical records using a standardized data collection form.ResultsA total of 566 patients with suspect COVID-19 infection were enrolled (280 were COVID-19+). The COVID-19 population was characterized with bilateral-pneumonia, a lower count of neutrophil, lymphocyte and mon...
Source: Immunity, Inflammation and Disease - May 7, 2021 Category: Allergy & Immunology Authors: Claudio Ucciferri, Luca Caiazzo, Marta Di Nicola, Paola Borrelli, Michela Pontolillo, Antonio Auricchio, Jacopo Vecchiet, Katia Falasca Tags: ORIGINAL ARTICLE Source Type: research

Dupilumab rapidly improves asthma control in predominantly anti ‐IL5/IL5R pretreated Austrian real‐life severe asthmatics
This is a real-life study that shows that dupilumab is effective and safe in Austrian real-life severe asthmatics. It rapidly improved asthma control. These improvements are comparable to previous randomized controlled trials. AbstractDupilumab is a monoclonal antibody against the IL-4 receptor alpha which has shown efficacy in T2 high severe asthmatics in phase 3 randomized controlled trials. The purpose of this real-life study is to demonstrate the real-life effectiveness of dupilumab in Austrian severe asthma patients. We retrospectively analyzed all patients receiving dupilumab at our severe asthma clinic. Thirteen pat...
Source: Immunity, Inflammation and Disease - May 7, 2021 Category: Allergy & Immunology Authors: Andreas Renner, Katharina Marth, Karin Patocka, Marco Idzko, Wolfgang Pohl Tags: COMMENTARY Source Type: research

PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability
ConclusionFindings from our work uncovered that PAQR3 inhibited proliferation and aggravated ferroptosis in ALL through modulation Nrf2 stability. This study suggested that PAQR3 may serve as an effective biological marker for ALL treatment. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - May 6, 2021 Category: Allergy & Immunology Authors: Ling Jin, Laigen Tong Tags: ORIGINAL ARTICLE Source Type: research

Expression of OPN3 in acral lentiginous melanoma and its associated with clinicohistopathologic features and prognosis
Graphical abstractAcral lentiginous melanoma has a poor prognosis due to delayed diagnosis aggressive biological behavior. However, its molecule features associated with prognosis remains largely unknown. We have detected the expression characteristic of OPN3 in ALMs, and demonstrated that high OPN3 is a negative prognostic indicator. AbstractBackgroundOPN3 upregulation associated with metastasis was recently described in two subtypes of lung cancers. And OPN3 identified in light-independent functions in epidermal melanocytes has already shown promise. However, in malignant melanocytic tissues, the expression and character...
Source: Immunity, Inflammation and Disease - May 6, 2021 Category: Allergy & Immunology Authors: Wen Zeng, Wei Zhang, Jianglong Feng, Xiaoyan He, Hongguang Lu Tags: ORIGINAL ARTICLE Source Type: research

The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles ‐resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11
This study aimed to investigate the effects of ritonavir (RIT) onC. albicans and the correlation betweenSAP2 as well asERG11 and drug resistance.ResultsSecreted aspartyl proteinases (Saps) activities and pathogenicity ofC. albicans with different drug resistance were measured. M27-A4 broth microdilution method was used to analyze the drug sensitivity of RIT combined with fluconazole (FCA) onC. albicans. After that,SAP2 andERG11 mutations were examined by polymerase chain reaction (PCR) and sequencing, and quantitative real-time PCR was utilized to determine the expression of the two genes. By analyzingpz values, the Saps a...
Source: Immunity, Inflammation and Disease - May 5, 2021 Category: Allergy & Immunology Authors: Wenli Feng, Jing Yang, Yan Ma, Zhiqin Xi, Xiaoqin Zhao, Xiaoxia Zhao, Min Zhao Tags: ORIGINAL RESEARCH Source Type: research