Genes, Vol. 15, Pages 528: Transcriptome Analysis on the Quality of Epimedium & nbsp;koreanum in Different Soil Moisture Conditions at Harvesting Stage
Genes, Vol. 15, Pages 528: Transcriptome Analysis on the Quality of Epimedium koreanum in Different Soil Moisture Conditions at Harvesting Stage
Genes doi: 10.3390/genes15050528
Authors:
Yonggang Zhang
Dantong Wang
Feng Wu
Xiangdi Huang
Xiaowei Chai
Limin Yang
Epimedium koreanum is a traditional Chinese tonic herb. Its main medicinal components are secondary metabolites such as flavonoids and flavonol glycosides, but the biosynthetic mechanism is still unclear. Moisture conditions are a key environmental factor affecting E. koreanum medicinal components during harvesting. Different stages of E. k...
Source: Genes - April 23, 2024 Category: Genetics & Stem Cells Authors: Yonggang Zhang Dantong Wang Feng Wu Xiangdi Huang Xiaowei Chai Limin Yang Tags: Article Source Type: research
Comprehensive characterization of Epimedium-Rhizoma drynariae herb pair in rat plasma, urine, and feces metabolic profiles by UHPLC-Q-Orbitrap HRMS combined with diagnostic extraction strategy and multicomponent pharmacokinetic study by UHPLC-MS/MS
This study increased the understanding of the material basis and biotransformation profiles of EP-RD in vivo, which was of great significance in exploring the pharmacological effects of EP-RD.PMID:38649516 | DOI:10.1007/s00216-024-05292-y (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - April 22, 2024 Category: Chemistry Authors: Qiuyu Li Mengxin Ren Yanzhu Liu Feng Qin Zhili Xiong Source Type: research
Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis
This study aimed to develop a sustainable and effective biphasic enzymatic hydrolysis system for the efficient conversion of epimedin C to icariin. The biphasic system was created using butyl acetate and phosphate buffer (pH 4.5) at a ratio of 3:1 (V/V) along with α-L-rhamnosidase/epimedin C (2 U/1 mg) at 50 °C for 12 h. Consequently, 98.21% of epimedin C was hydrolysed to icariin, with 95.62% of the product being transferred to the organic phase. Even after four cycles of use, the conversion ratio remained high at 75.28%. Furthermore, this novel strategy was also used for the conversion of Epimedium brevicornu Maxim. ex...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Wang Chen Yue Zhang Yuhang Zhang Zili Feng Xu He Source Type: research
Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis
This study aimed to develop a sustainable and effective biphasic enzymatic hydrolysis system for the efficient conversion of epimedin C to icariin. The biphasic system was created using butyl acetate and phosphate buffer (pH 4.5) at a ratio of 3:1 (V/V) along with α-L-rhamnosidase/epimedin C (2 U/1 mg) at 50 °C for 12 h. Consequently, 98.21% of epimedin C was hydrolysed to icariin, with 95.62% of the product being transferred to the organic phase. Even after four cycles of use, the conversion ratio remained high at 75.28%. Furthermore, this novel strategy was also used for the conversion of Epimedium brevicornu Maxim. ex...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Wang Chen Yue Zhang Yuhang Zhang Zili Feng Xu He Source Type: research
GSE259444 Exploring the Dynamic Adaptive Responses of Epimedium pubescens to Phosphorus Deficiency Through Combined Transcriptome and miRNA Analysis [miRNA-Seq]
Contributors : Shangnian Liu ; Xiaojing AnSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Epimedium pubescensIn the early stages (30 days) of phosphorus deficiency stress, Epimedium pubescens leaves cope with short-term phosphorus deficiency by increasing the expression of related genes such as carbon metabolism, flavonoid synthesis and hormone signal transduction pathways, producing sufficient energy, scavenging ROS, and adjusting plant morphology. However, with the extension of stress duration to 90 days, the expression of genes related to phosphorus cycling and phosphorus recovery (PHT1-...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Epimedium pubescens Source Type: research
GSE259442 Exploring the Dynamic Adaptive Responses of Epimedium pubescens to Phosphorus Deficiency Through Combined Transcriptome and miRNA Analysis [RNA-Seq]
Contributors : Shangnian Liu ; Xiaojing AnSeries Type : Expression profiling by high throughput sequencingOrganism : Epimedium pubescensIn the early stages (30 days) of phosphorus deficiency stress, Epimedium pubescens leaves cope with short-term phosphorus deficiency by increasing the expression of related genes such as carbon metabolism, flavonoid synthesis and hormone signal transduction pathways, producing sufficient energy, scavenging ROS, and adjusting plant morphology. However, with the extension of stress duration to 90 days, the expression of genes related to phosphorus cycling and phosphorus recovery (PHT1-4, P...
Source: GEO: Gene Expression Omnibus - March 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Epimedium pubescens Source Type: research
Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition
In this study, we aimed to explore the effect of icariin on osteoclastogenesis and its potential mechanism from the perspective of oxidative stress inhibition, using ovariectomized (OVX) rats and RANKL-induced RAW264.7 cells. Our results demonstrated that icariin-treated OVX rats exhibited higher bone density, fewer tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts, and lower ROS levels in bone tissues than vehicle-treated OVX rats. Also, icariin suppressed osteoclast differentiation and inhibited the expression of osteoclastogenesis-related genes, such as NFATc1, Ctsk, Trap, and c-Fos, in RANKL-induced RAW26...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 12, 2024 Category: Drugs & Pharmacology Authors: Yuhao Si Yan Li Kuan Gu Heng Yin Yong Ma Source Type: research
Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition
In this study, we aimed to explore the effect of icariin on osteoclastogenesis and its potential mechanism from the perspective of oxidative stress inhibition, using ovariectomized (OVX) rats and RANKL-induced RAW264.7 cells. Our results demonstrated that icariin-treated OVX rats exhibited higher bone density, fewer tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts, and lower ROS levels in bone tissues than vehicle-treated OVX rats. Also, icariin suppressed osteoclast differentiation and inhibited the expression of osteoclastogenesis-related genes, such as NFATc1, Ctsk, Trap, and c-Fos, in RANKL-induced RAW26...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 12, 2024 Category: Drugs & Pharmacology Authors: Yuhao Si Yan Li Kuan Gu Heng Yin Yong Ma Source Type: research
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome
Immunology. 2024 Mar 7. doi: 10.1111/imm.13771. Online ahead of print.ABSTRACTHyperactivation of the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signalling pathway has been shown to be associated with the development of a variety of inflammatory diseases, and the discovery of an inhibitor of the cGAS-STING signalling pathway holds great promise in the therapeutic interventions. Epimedium flavonoid (EF), a major active ingredient isolated from the medicinal plant Epimedium, has been reported to have good anti-inflammatory activity, but its exact mechanism of action remains unclear. In the present s...
Source: Immunology - March 7, 2024 Category: Allergy & Immunology Authors: Yan Wang Guang Xu Jincai Wen Xiaomei Zhao Huanying Zhao Guiji Lv Yingjie Xu Ye Xiu Junjie Li Simin Chen Qing Yao Yuanyuan Chen Lina Ma Xiaohe Xiao Junling Cao Zhaofang Bai Source Type: research
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome
Immunology. 2024 Mar 7. doi: 10.1111/imm.13771. Online ahead of print.ABSTRACTHyperactivation of the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signalling pathway has been shown to be associated with the development of a variety of inflammatory diseases, and the discovery of an inhibitor of the cGAS-STING signalling pathway holds great promise in the therapeutic interventions. Epimedium flavonoid (EF), a major active ingredient isolated from the medicinal plant Epimedium, has been reported to have good anti-inflammatory activity, but its exact mechanism of action remains unclear. In the present s...
Source: Immunology - March 7, 2024 Category: Allergy & Immunology Authors: Yan Wang Guang Xu Jincai Wen Xiaomei Zhao Huanying Zhao Guiji Lv Yingjie Xu Ye Xiu Junjie Li Simin Chen Qing Yao Yuanyuan Chen Lina Ma Xiaohe Xiao Junling Cao Zhaofang Bai Source Type: research
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome
Immunology. 2024 Mar 7. doi: 10.1111/imm.13771. Online ahead of print.ABSTRACTHyperactivation of the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signalling pathway has been shown to be associated with the development of a variety of inflammatory diseases, and the discovery of an inhibitor of the cGAS-STING signalling pathway holds great promise in the therapeutic interventions. Epimedium flavonoid (EF), a major active ingredient isolated from the medicinal plant Epimedium, has been reported to have good anti-inflammatory activity, but its exact mechanism of action remains unclear. In the present s...
Source: Immunology - March 7, 2024 Category: Allergy & Immunology Authors: Yan Wang Guang Xu Jincai Wen Xiaomei Zhao Huanying Zhao Guiji Lv Yingjie Xu Ye Xiu Junjie Li Simin Chen Qing Yao Yuanyuan Chen Lina Ma Xiaohe Xiao Junling Cao Zhaofang Bai Source Type: research
Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells
In conclusion, ICT increased intracellular ROS levels in liver cancer cells, which promoted the stabilization and activation of p53, inhibiting the expression of aerobic glycolysis-related genes and glycolysis, and ultimately leading to the suppression of liver cancer development.PMID:38431053 | DOI:10.1016/j.cbi.2024.110926 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 2, 2024 Category: Molecular Biology Authors: Xiangyang Zhou Di Wu Tian Mi Ruohan Li Tao Guo Wenjuan Li Source Type: research
Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2
CONCLUSIONS: ICA alleviated motor impairments in A53T mice, an effect which may be associated with the decreased phosphorylation and aggregation of α-synuclein through PLK2 and parkin regulation.PMID:38176950 | DOI:10.31083/j.jin2206166 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Denglei Ma Cong Shen Xu Zhang Lan Zhang Lin Li Source Type: research
Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2
CONCLUSIONS: ICA alleviated motor impairments in A53T mice, an effect which may be associated with the decreased phosphorylation and aggregation of α-synuclein through PLK2 and parkin regulation.PMID:38176950 | DOI:10.31083/j.jin2206166 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Denglei Ma Cong Shen Xu Zhang Lan Zhang Lin Li Source Type: research
Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2
CONCLUSIONS: ICA alleviated motor impairments in A53T mice, an effect which may be associated with the decreased phosphorylation and aggregation of α-synuclein through PLK2 and parkin regulation.PMID:38176950 | DOI:10.31083/j.jin2206166 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 4, 2024 Category: Neuroscience Authors: Denglei Ma Cong Shen Xu Zhang Lan Zhang Lin Li Source Type: research
