The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function
Immunology. 2024 Mar 21. doi: 10.1111/imm.13779. Online ahead of print.ABSTRACTAnalysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation of either the human interferon regulatory factor 9 (IRF9) or the signal transducer and activator of transcription 2 (STAT2) genes. IRF9...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Ane Calvo-Apalategi Marta L ópez Nevado Luz Yadira Bravo-Gallego Luis Ignacio Gonz ález-Granado Luis M Allende Rebeca Rodr íguez Pena Eduardo L ópez-Granados Hugh T Reyburn Source Type: research

A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: Multi-pathway combination therapy with PD-1/PD-L1 inhibitors
Immunology. 2024 Mar 22. doi: 10.1111/imm.13785. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC known as 'cold' tumours that are resistant to immunosuppressive drugs. Monotherapy with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi-pathway regimens combined w...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Lingli Cai Anqi Chen Dong Tang Source Type: research

The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function
Immunology. 2024 Mar 21. doi: 10.1111/imm.13779. Online ahead of print.ABSTRACTAnalysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation of either the human interferon regulatory factor 9 (IRF9) or the signal transducer and activator of transcription 2 (STAT2) genes. IRF9...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Ane Calvo-Apalategi Marta L ópez Nevado Luz Yadira Bravo-Gallego Luis Ignacio Gonz ález-Granado Luis M Allende Rebeca Rodr íguez Pena Eduardo L ópez-Granados Hugh T Reyburn Source Type: research

A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: Multi-pathway combination therapy with PD-1/PD-L1 inhibitors
Immunology. 2024 Mar 22. doi: 10.1111/imm.13785. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC known as 'cold' tumours that are resistant to immunosuppressive drugs. Monotherapy with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi-pathway regimens combined w...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Lingli Cai Anqi Chen Dong Tang Source Type: research

The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function
Immunology. 2024 Mar 21. doi: 10.1111/imm.13779. Online ahead of print.ABSTRACTAnalysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation of either the human interferon regulatory factor 9 (IRF9) or the signal transducer and activator of transcription 2 (STAT2) genes. IRF9...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Ane Calvo-Apalategi Marta L ópez Nevado Luz Yadira Bravo-Gallego Luis Ignacio Gonz ález-Granado Luis M Allende Rebeca Rodr íguez Pena Eduardo L ópez-Granados Hugh T Reyburn Source Type: research

A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: Multi-pathway combination therapy with PD-1/PD-L1 inhibitors
Immunology. 2024 Mar 22. doi: 10.1111/imm.13785. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC known as 'cold' tumours that are resistant to immunosuppressive drugs. Monotherapy with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi-pathway regimens combined w...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Lingli Cai Anqi Chen Dong Tang Source Type: research

The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function
Immunology. 2024 Mar 21. doi: 10.1111/imm.13779. Online ahead of print.ABSTRACTAnalysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation of either the human interferon regulatory factor 9 (IRF9) or the signal transducer and activator of transcription 2 (STAT2) genes. IRF9...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Ane Calvo-Apalategi Marta L ópez Nevado Luz Yadira Bravo-Gallego Luis Ignacio Gonz ález-Granado Luis M Allende Rebeca Rodr íguez Pena Eduardo L ópez-Granados Hugh T Reyburn Source Type: research

A new strategy for immunotherapy of microsatellite-stable (MSS)-type advanced colorectal cancer: Multi-pathway combination therapy with PD-1/PD-L1 inhibitors
Immunology. 2024 Mar 22. doi: 10.1111/imm.13785. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR)-microsatellite instability-low (MSI-L)/microsatellite stable (MSS) CRC known as 'cold' tumours that are resistant to immunosuppressive drugs. Monotherapy with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi-pathway regimens combined w...
Source: Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Lingli Cai Anqi Chen Dong Tang Source Type: research

Inhibition of leukotriene-B4 signalling-mediated host response to tuberculosis is a potential mode of adjunctive host-directed therapy
This study provides a new mode of TB treatment along with mechanistic insights which can be further explored in pre-clinical trials.PMID:38504502 | DOI:10.1111/imm.13781 (Source: Immunology)
Source: Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Ushashi Banerjee Salik Miskat Borbora Madhura Guha Vikas Yadav V Sanjay Amit Singh Kithiganahalli Narayanaswamy Balaji Nagasuma Chandra Source Type: research

Inhibition of leukotriene-B4 signalling-mediated host response to tuberculosis is a potential mode of adjunctive host-directed therapy
This study provides a new mode of TB treatment along with mechanistic insights which can be further explored in pre-clinical trials.PMID:38504502 | DOI:10.1111/imm.13781 (Source: Immunology)
Source: Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Ushashi Banerjee Salik Miskat Borbora Madhura Guha Vikas Yadav V Sanjay Amit Singh Kithiganahalli Narayanaswamy Balaji Nagasuma Chandra Source Type: research

Inhibition of leukotriene-B4 signalling-mediated host response to tuberculosis is a potential mode of adjunctive host-directed therapy
This study provides a new mode of TB treatment along with mechanistic insights which can be further explored in pre-clinical trials.PMID:38504502 | DOI:10.1111/imm.13781 (Source: Immunology)
Source: Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Ushashi Banerjee Salik Miskat Borbora Madhura Guha Vikas Yadav V Sanjay Amit Singh Kithiganahalli Narayanaswamy Balaji Nagasuma Chandra Source Type: research

Single-cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus (hCMV)-specific memory T cells reveals effectors and pre-effectors of CD8 < sup > + < /sup > - and CD4 < sup > + < /sup > -cytotoxic T cells
Immunology. 2024 Mar 19. doi: 10.1111/imm.13783. Online ahead of print.ABSTRACTLatent human cytomegalovirus (hCMV) infection can pose a serious threat of reactivation and disease occurrence in immune-compromised individuals. Although T cells are at the core of the protective immune response to hCMV infection, a detailed characterization of different T cell subsets involved in hCMV immunity is lacking. Here, in an unbiased manner, we characterized over 8000 hCMV-reactive peripheral memory T cells isolated from seropositive human donors, at a single-cell resolution by analysing their single-cell transcriptomes paired with th...
Source: Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Raunak Kar Somdeb Chattopadhyay Anjali Sharma Kirti Sharma Shreya Sinha Gopalakrishnan Aneeshkumar Arimbasseri Veena S Patil Source Type: research

Id1 expression in CD4 T cells promotes differentiation and function of follicular helper T cells and upregulation of related functional molecules
In conclusion, E proteins play a crucial role in regulating TFH/TFR cell differentiation and function and suppressing E protein activity promotes germinal centre humoral immunity, which has important implications for immune regulation and treating related diseases.PMID:38501859 | DOI:10.1111/imm.13782 (Source: Immunology)
Source: Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Chen Liu Xingyue Zeng Ziqi Xiong Ayibaota Bahabayi Ainizati Hasimu Tianci Liu Mohan Zheng Liwei Ren Xiayidan Alimu Songsong Lu Source Type: research

Sialic acid in the regulation of blood cell production, differentiation and turnover
Immunology. 2024 Mar 19. doi: 10.1111/imm.13780. Online ahead of print.ABSTRACTSialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying structures has long been postulated, but the means by which such structural changes directly affect biological processes continues to be elucidated. Here, we appraise the growing body of literature detailing the importance of sialic acid for the generation, differentiation, function and death of haematopoietic cell...
Source: Immunology - March 19, 2024 Category: Allergy & Immunology Authors: Eric Edward Irons Sajina Gc Joseph T Y Lau Source Type: research

Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation. Pro-inflammatory effects of TNFα/IL-1β and OxPAPC were estimated by analysis of chemokines CXCL8, CXCL2 and CXCL3 by ELISA and RT-PCR. Toxicity was determined by analysis of metabolic ...
Source: Immunology - March 12, 2024 Category: Allergy & Immunology Authors: Alma Hodzic Bernd Gesslbauer Valery Bochkov Olga V Oskolkova Source Type: research