Regulatory T cells control epitope spreading in autoimmune arthritis independent of CTLA-4.
This article is protected by copyright. All rights reserved. PMID: 29992549 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 10, 2018 Category: Allergy & Immunology Authors: Yang M, Klocke K, Marquina Hernandez C, Xu B, Gjertsson I, Wing K, Holmdahl R Tags: Immunology Source Type: research

Characterising a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.
This article is protected by copyright. All rights reserved. PMID: 29981529 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 7, 2018 Category: Allergy & Immunology Authors: Zelek WM, Stott M, Walters D, Harris CL, Morgan BP Tags: Immunology Source Type: research

Low molecule mass hyaluronan induces pulmonary inflammation by up-regulation of Mcl-1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway.
This article is protected by copyright. All rights reserved. PMID: 29975419 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 5, 2018 Category: Allergy & Immunology Authors: Zhao H, Ma Y, Zhang L Tags: Immunology Source Type: research

Local exchange of metabolites shapes immunity.
This article is protected by copyright. All rights reserved. PMID: 29972686 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Richter FC, Obba S, Simon AK Tags: Immunology Source Type: research

Evaluation of the immune response against Trypanosoma cruzi cytosolic Tryparedoxin Peroxidase in human natural infection.
This article is protected by copyright. All rights reserved. PMID: 29972690 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Girard MC, Acevedo GR, López L, Ossowski MS, Piñeyro MD, Grosso JP, Fernandez M, Hernández Vasquez Y, Robello C, Gómez KA Tags: Immunology Source Type: research

Interleukin-6 signaling mediates Galectin-8 costimulatory activity of antigen-specific CD4 T cell response.
This article is protected by copyright. All rights reserved. PMID: 29972692 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Carabelli J, Prato CA, Sanmarco LM, Aoki MP, Campetella O, Tribulatti MV Tags: Immunology Source Type: research

Peyer's patches-derived CD11b+ B cells recruit regulatory T cells through CXCL9 in DSS-induced colitis.
This study, based on the dextran sulfate sodium (DSS)-induced colitis model, revealed that Tregs are significantly increased in PPs, along with CD11b+ B cell induction. Immunofluorescence staining showed that infiltrated Tregs were located around CD11b+ B cells and produced TGF-β, thereby inducing IgA+ B cells. Furthermore, in vivo and in vitro studies revealed that CD11b+ B cells in PPs had the capacity to recruit Tregs into PPs rather than promoting their proliferation. Finally, we found that Treg recruitment was mediated by the chemokine CXCL9 derived from CD11b+ B cells in PPs. These findings demonstrate that CD11...
Source: Immunology - July 3, 2018 Category: Allergy & Immunology Authors: Wang Z, Zhang H, Liu R, Qian T, Liu J, Huang E, Lu Z, Zhao C, Wang L, Chu Y Tags: Immunology Source Type: research

Macrophage targeting: opening new possibilities for cancer immunotherapy.
This article is protected by copyright. All rights reserved. PMID: 29963704 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 2, 2018 Category: Allergy & Immunology Authors: Cassetta L, Kitamura T Tags: Immunology Source Type: research

New tools for MHC research from machine learning and predictive algorithms to the tumour immunopeptidome.
Abstract At a time when immunology seeks to progress ever more rapidly from characterization of a microbial or tumour antigen to the immune correlates that may define protective T-cell immunity, there is a need for robust tools to enable accurate predictions of peptide-major histocompatibility complex (pMHC) and peptide-MHC-T-cell receptor binding. Improvements in the curation of data sets from high throughput pMHC analysis, such as the NIH Immune Epitope Database (IEDB), and the associated developments of predictive tools rooted in machine-learning approaches, are having significant impact. When such approaches a...
Source: Immunology - June 15, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

The interaction between iNKT cells and the mucosal microbiota.
This article is protected by copyright. All rights reserved. PMID: 29893412 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - June 12, 2018 Category: Allergy & Immunology Authors: Hapil FZ, Wingender G Tags: Immunology Source Type: research

TLR4 signaling regulates antibody response to adenoviral vector-based vaccines by imprinting germinal center quality.
This article is protected by copyright. All rights reserved. PMID: 29876918 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - June 7, 2018 Category: Allergy & Immunology Authors: Li R, Liu J, Wu S, Zai X, Li Y, Yang Q, Hou L, Xu J, Chen W Tags: Immunology Source Type: research

Neuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease.
Abstract An ever-increasing collection of neurological human diseases are becoming appreciated as encompassing a strong immunological component in pathogenesis or regulation. This derives to a large extent from genome-wide association studies that have highlighted association with immune system genes, including those in the HLA and KIR regions. Along with the genomic findings have come insights from immune phenotyping and assays for autoimmunity. This is a group of disease processes that includes Parkinson's disease, Alzheimer's, stroke, narcolepsy, schizophrenia and psychosis. In most cases, these are diseases in...
Source: Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

ImmTAC/Anti-PD-1 Combination to Enhance Killing of Cancer cells by Reversing Treg-mediated Immunosuppression.
This article is protected by copyright. All rights reserved. PMID: 29791021 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 23, 2018 Category: Allergy & Immunology Authors: Zhang H, Li Y, Liu X, Liang Z, Yan M, Liu Q, Chen A, Bao Y, Zhou C, Li S, Yee C, Li Y Tags: Immunology Source Type: research

Helper T-Cell Responses and Pulmonary Fungal Infections.
This article is protected by copyright. All rights reserved. PMID: 29781185 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 20, 2018 Category: Allergy & Immunology Authors: McDermott AJ, Klein BS Tags: Immunology Source Type: research

Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity.
This article is protected by copyright. All rights reserved. PMID: 29771448 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Flannigan KL, Denning TL Tags: Immunology Source Type: research

Nature of tumor rejection antigens in ovarian cancer.
This article is protected by copyright. All rights reserved. PMID: 29772069 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Want MY, Lugade AA, Battaglia S, Odunsi K Tags: Immunology Source Type: research

CD6 mAbs differ in epitope, kinetics and mechanism of action.
This article is protected by copyright. All rights reserved. PMID: 29772075 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Garner LI, Hartland A, Breuning J, Brown MH Tags: Immunology Source Type: research

Tumor YAP1 and PTEN expression correlates with tumor-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer.
Abstract The expansion of myeloid-derived suppressor cells (MDSCs) correlates with tumorigenesis in colorectal cancer (CRC). Here, we found a significant association between CD33+ MDSC number and YAP1 and PTEN levels in CRC patients (P
Source: Immunology - May 16, 2018 Category: Allergy & Immunology Authors: Yang R, Cai TT, Wu XJ, Liu YN, He J, Zhang XS, Ma G, Li J Tags: Immunology Source Type: research

Salivary gland-protective regulatory T cell dysfunction underlies female-specific sialadenitis in the nonobese diabetic mouse model of Sj ögren syndrome.
This article is protected by copyright. All rights reserved. PMID: 29750331 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 11, 2018 Category: Allergy & Immunology Authors: Barr JY, Wang X, Kreiger PA, Lieberman SM Tags: Immunology Source Type: research

MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.
Abstract Innate immune cells are integral to the pathogenesis of several diseases of the central nervous system (CNS), including multiple sclerosis (MS). Dendritic cells (DCs) are potent CD11c+ antigen-presenting cells that are critical regulators of adaptive immune responses, particularly in autoimmune diseases such as MS. The regulation of DC function in both the periphery and CNS compartment has not been fully elucidated. One limitation to studying the role of CD11c+ DCs in the CNS is that microglia can upregulate CD11c during inflammation, making it challenging to distinguish bone marrow-derived DCs (BMDCs) fr...
Source: Immunology - May 10, 2018 Category: Allergy & Immunology Authors: Hoye ML, Archambault AS, Gordon TM, Oetjen LK, Cain MD, Klein RS, Crosby SD, Kim BS, Miller TM, Wu GF Tags: Immunology Source Type: research

End-stage renal disease, dialysis, kidney transplantation and their impact on CD4+ -T-cell differentiation.
This article is protected by copyright. All rights reserved. PMID: 29722011 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 2, 2018 Category: Allergy & Immunology Authors: Schaier M, Leick A, Uhlmann L, Kälble F, Morath C, Eckstein V, Ho A, Mueller-Tidow C, Meuer S, Mahnke K, Sommerer C, Zeier M, Steinborn A Tags: Immunology Source Type: research

IL-23 promotes intestinal Th17 immunity and ameliorates obesity associated metabolic syndrome in a murine high-fat diet model.
This article is protected by copyright. All rights reserved. PMID: 29722014 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 2, 2018 Category: Allergy & Immunology Authors: Martins LMS, Perez MM, Pereira CA, Costa FRC, Dias MS, Tostes RC, Ramos SG, de Zoete MR, Ryffel B, Silva JS, Carlos D Tags: Immunology Source Type: research

Differential TCR signals for T helper cell programming.
This article is protected by copyright. All rights reserved. PMID: 29722021 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 2, 2018 Category: Allergy & Immunology Authors: Morel PA Tags: Immunology Source Type: research

Mapping innate and adaptive immune function in arbovirus infections.
PMID: 29667753 [PubMed - in process] (Source: Immunology)
Source: Immunology - April 19, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

Mapping the tumour HLA ligandome by mass spectrometry.
This article is protected by copyright. All rights reserved. PMID: 29658117 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - April 15, 2018 Category: Allergy & Immunology Authors: Freudenmann LK, Marcu A, Stevanović S Tags: Immunology Source Type: research

A humanized TCR retaining authentic specificity and affinity conferred potent anti-tumor cytotoxicity.
This article is protected by copyright. All rights reserved. PMID: 29645087 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - April 12, 2018 Category: Allergy & Immunology Authors: Chen L, Tian Y, Zhan K, Chen A, Weng Z, Huang J, Li Y, Sun Y, Zheng H, Li Y Tags: Immunology Source Type: research

Impacts of microbiome metabolites on immune regulation and autoimmunity.
This article is protected by copyright. All rights reserved. PMID: 29637999 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - April 11, 2018 Category: Allergy & Immunology Authors: Haase S, Haghikia A, Wilck N, Müller DN, Linker RA Tags: Immunology Source Type: research

Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.
In conclusion, Arg II was identified as a factor promoting EAE likely via an Arg I-independent mechanism. Arg II may promote EAE by enhancing DC production of Th17-differentiating cytokines. Specific inhibition of Arg II could be a potential therapy for MS. This article is protected by copyright. All rights reserved. PMID: 29574762 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 25, 2018 Category: Allergy & Immunology Authors: Choudry M, Tang X, Santorian T, Wasnik S, Xiao J, Xing W, Lau KW, Mohan S, Baylink DJ, Qin X Tags: Immunology Source Type: research

Antibody repertoire analysis in polygenic autoimmune diseases.
Abstract High-throughput sequencing of the DNA/RNA encoding antibody heavy and light chains is rapidly transforming the field of adaptive immunity. It can address key questions including (i) how the B-cell repertoire differs in health and disease and (ii) if it does differ, the point(s) in B-cell development at which this occurs. The advent of technologies, such as whole genome sequencing, offers the chance to link abnormalities in the B-cell antibody repertoire to specific genomic variants and polymorphisms. Here, we discuss the current research using B-cell antibody repertoire sequencing in three polygenic autoi...
Source: Immunology - March 25, 2018 Category: Allergy & Immunology Authors: Bashford-Rogers RJM, Smith KGC, Thomas DC Tags: Immunology Source Type: research

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination.
This article is protected by copyright. All rights reserved. PMID: 29570776 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 23, 2018 Category: Allergy & Immunology Authors: Gray JI, Westerhof LM, MacLeod MKL Tags: Immunology Source Type: research

Defining the role of NK cells during dengue virus infection.
This article is protected by copyright. All rights reserved. PMID: 29570783 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 23, 2018 Category: Allergy & Immunology Authors: Mathew A Tags: Immunology Source Type: research

Immune regulation by microbiome metabolites.
This article is protected by copyright. All rights reserved. PMID: 29569377 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 22, 2018 Category: Allergy & Immunology Authors: Kim CH Tags: Immunology Source Type: research

Antigen-specific airway IL-33 production depends on Fc γR-mediated incorporation of the antigen by alveolar macrophages in sensitized mice.
This article is protected by copyright. All rights reserved. PMID: 29569388 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 22, 2018 Category: Allergy & Immunology Authors: Nabe T, Matsuda M, Ishida T, Tsujimoto N, Kido H, Kanaya H, Takahashi H, Takemoto N, Nomura M, Ishihara K, Akiba S, Mizutani N Tags: Immunology Source Type: research

Innate-like CD8+ T cells and NK cells: converging functions and phenotypes.
This article is protected by copyright. All rights reserved. PMID: 29542114 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 14, 2018 Category: Allergy & Immunology Authors: Kurioka A, Klenerman P, Willberg C Tags: Immunology Source Type: research

Murine neutrophils treated with alphaB-crystallin reduce IL-12p40 production by dendritic cells.
This article is protected by copyright. All rights reserved. PMID: 29532462 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 13, 2018 Category: Allergy & Immunology Authors: Finlay TM, Palmer AL, Ousman SS Tags: Immunology Source Type: research

NK Cell Cytotoxicity And Its Regulation By Inhibitory Receptors.
This article is protected by copyright. All rights reserved. PMID: 29512837 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Kumar S Tags: Immunology Source Type: research

Regulation of autoimmune and anti-tumour T cell responses by PTPN22.
This article is protected by copyright. All rights reserved. PMID: 29512901 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Brownlie RJ, Zamoyska R, Salmond RJ Tags: Immunology Source Type: research

EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances γδT cell-mediated cytotoxicity via TCR and NKG2D.
This article is protected by copyright. All rights reserved. PMID: 29512904 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Yu-Mei D, Liu HY, Liu YF, Zhang Y, He W Tags: Immunology Source Type: research

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T cell-associated autoimmunity.
In conclusion, we report here that high salt intake affects both lymphoid and myeloid cells ex vivo. However, the effects of high salt intake in vivo seem less pronounced in terms of CD4+ T cell responses, whereas macrophage-dependent pathologies are significantly influenced. This article is protected by copyright. All rights reserved. PMID: 29513375 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Vaartjes D, Nandakumar KS, Holmdahl R, Raposo B Tags: Immunology Source Type: research

Inflammation in CNS Neurodegenerative Diseases.
This article is protected by copyright. All rights reserved. PMID: 29513402 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Stephenson J, Nutma E, van der Valk P, Amor S Tags: Immunology Source Type: research

Immune responses in stroke: How the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?
This article is protected by copyright. All rights reserved. PMID: 29494762 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - March 1, 2018 Category: Allergy & Immunology Authors: Rayasam A, Hsu M, Kijak JA, Kissel L, Hernandez G, Sandor M, Fabry Z Tags: Immunology Source Type: research

Corrigendum.
Authors: PMID: 29392768 [PubMed - in process] (Source: Immunology)
Source: Immunology - February 4, 2018 Category: Allergy & Immunology Tags: Immunology Source Type: research

Immune modulatory effects of statins.
This article is protected by copyright. All rights reserved. PMID: 29392731 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Zeiser R Tags: Immunology Source Type: research

The Role of Gut Microbiome and Associated Metabolome in the Regulation of Neuroinflammation in Multiple Sclerosis and Its Implications in Attenuating Chronic Inflammation in Other Inflammatory and Autoimmune Disorders.
This article is protected by copyright. All rights reserved. PMID: 29392733 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Dopkins N, Nagarkatti PS, Nagarkatti M Tags: Immunology Source Type: research

Cholera toxin enhances IL-17A production in both CD4+ and CD8+ cells via a cAMP/PKA-mediated IL-17A promoter activation.
In conclusion, our data suggest that CT induces an IL-17A-dominated immune microenvironment via cAMP/PKA/CREB signaling pathway. Our study also highlights the potentials of CT and cAMP in modulating Th17 responses in vivo. This article is protected by copyright. All rights reserved. PMID: 29377102 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 27, 2018 Category: Allergy & Immunology Authors: Tsa HC, Velichko S, Lee S, Wu R Tags: Immunology Source Type: research

Daily very low UV dose exposure enhances adaptive immunity, compared with a single high dose exposure. Consequences on the control of a skin infection.
This article is protected by copyright. All rights reserved. PMID: 29377107 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 27, 2018 Category: Allergy & Immunology Authors: Cela EM, Gonzalez CD, Friedrich A, Ledo C, Paz ML, Leoni J, Gomez MI, González Maglio DH Tags: Immunology Source Type: research

Galectin-3 is an amplifier of the interleukin-1 β-mediated inflammatory response in corneal keratinocytes.
This article is protected by copyright. All rights reserved. PMID: 29359328 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 22, 2018 Category: Allergy & Immunology Authors: Uchino Y, Woodward AM, Mauris J, Peterson K, Verma P, Nilsson UJ, Rajaiya J, Argüeso P Tags: Immunology Source Type: research

Origins of Natural Killer Cell Memory: Special Creation or Adaptive Evolution.
This article is protected by copyright. All rights reserved. PMID: 29355919 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 21, 2018 Category: Allergy & Immunology Authors: Holder KA, Comeau EM, Grant MD Tags: Immunology Source Type: research

Inhibition of the FGL2:Fc γRIIB/RIII Immunosuppressive Pathway Enhances Antiviral T cell and B Cell Responses Leading to Clearance of LCMV cl-13.
This article is protected by copyright. All rights reserved. PMID: 29341118 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 17, 2018 Category: Allergy & Immunology Authors: Klingberg O, Khattar R, Farrokhi K, Ferri D, Yavorska N, Zhang J, Sadozai H, Adeyi O, Chruscinski A, Levy GA, Selzner N Tags: Immunology Source Type: research

Adaptive Immune Education by Gut Microbiota Antigens.
This article is protected by copyright. All rights reserved. PMID: 29338074 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - January 16, 2018 Category: Allergy & Immunology Authors: Zhao Q, Elson CO Tags: Immunology Source Type: research