Functions of adipose-resident immune subsets and the impact on metabolic syndrome.
Abstract There is a growing appreciation of the role in the aetiology of metabolic syndrome that is played by the interplay of diet, microbiota and the interactions of immune cells and adipose cells in visceral adipose tissue. Recent studies have highlighted the programmes, properties and roles of the specialized, resident immune subsets that are abundant in adipose tissue, which may be considered a newly identified lymphoid compartment for immunology research. The findings indicate important roles for resident T effector and regulatory cells, innate lymphoid cells (ILCs), invariant natural killer T (iNKT) cells a...
Source: Immunology - November 14, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

Jagged1-expressing adenovirus-infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate Th2-mediated allergic asthma in mice.
This article is protected by copyright. All rights reserved. PMID: 30418664 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Lin CL, Huang HM, Hsieh CL, Fan CK, Lee YL Tags: Immunology Source Type: research

Interleukin-1 beta influences functional regeneration following nerve injury in mice through NF-kappa B signaling pathway.
CONCLUSIONS: IL-1β could benefit the recovery of sciatic nerve crush injury by facilitating nerve regeneration. This article is protected by copyright. All rights reserved. PMID: 30418673 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - November 12, 2018 Category: Allergy & Immunology Authors: Wu R, Chen B, Jia X, Qiu Y, Liu M, Huang C, Feng J, Wu Q Tags: Immunology Source Type: research

PRBAM: a new tool to analyze the MHC class I and HLA-DR anchor motifs.
This article is protected by copyright. All rights reserved. PMID: 30408168 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - November 8, 2018 Category: Allergy & Immunology Authors: Mestre-Ferrer A, Scholz E, Humet-Alsius J, Alvarez I Tags: Immunology Source Type: research

HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis.
This article is protected by copyright. All rights reserved. PMID: 30403401 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - November 7, 2018 Category: Allergy & Immunology Authors: Singh B, Fakiola M, Sudarshan M, Oommen J, Singh SS, Sundar S, Blackwell JM Tags: Immunology Source Type: research

Aldehyde Dehydrogenase in Regulatory T Cell Development, Immunity and Cancer.
This article is protected by copyright. All rights reserved. PMID: 30387499 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - November 2, 2018 Category: Allergy & Immunology Authors: Bazewicz CG, Dinavahi SS, Schell TD, Robertson GP Tags: Immunology Source Type: research

A Nobel Prize-worthy pursuit: cancer immunology and harnessing immunity to tumour neoantigens.
Abstract The field of cancer immunology stepped into the limelight this year when James P. Allison and Tasuku Honjo received the Nobel Prize in Physiology or Medicine for their discovery of cancer therapy by inhibition of negative immune regulation. Among many exciting advances contributing to the coming of age of tumour immunology as a viable clinical specialty has been the ability to progress from the initial elucidation of tumour antigens, such as the melanoma antigen, MAGE-1, to high-throughput sequencing facilitating identification of T cell epitopes from diverse tumour neoantigens. This has resulted from the...
Source: Immunology - October 16, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

Systems vaccinology and big data in the vaccine development chain.
This article is protected by copyright. All rights reserved. PMID: 30317555 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - October 14, 2018 Category: Allergy & Immunology Authors: Raeven RHM, van Riet E, Meiring HD, Metz B, Kersten GFA Tags: Immunology Source Type: research

Drebrin 1 in dendritic cells regulates phagocytosis and cell surface receptor expression through recycling for efficient antigen presentation.
This article is protected by copyright. All rights reserved. PMID: 30317558 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - October 14, 2018 Category: Allergy & Immunology Authors: Elizondo DM, Andargie TE, Haddock NL, Boddie TA, Lipscomb MW Tags: Immunology Source Type: research

Different phenotypes of non-classical monocytes associated with systemic inflammation, endothelial alteration and hepatic compromise in patients with dengue.
This article is protected by copyright. All rights reserved. PMID: 30315653 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - October 13, 2018 Category: Allergy & Immunology Authors: Naranjo-Gómez JS, Castillo A, Rojas M, Restrepo BN, Diaz FJ, Velilla PA, Castaño D Tags: Immunology Source Type: research

Addition of the C-terminus of CD6 to a chimeric antigen receptor enhances cytotoxicity and does not compromise expression.
This article is protected by copyright. All rights reserved. PMID: 30300924 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - October 9, 2018 Category: Allergy & Immunology Authors: Breuning J, Philip B, Brown MH Tags: Immunology Source Type: research

DNA prime-protein boost vaccine encoding HLA-A2, -A24 and -DR1 restricted epitopes of CaNA2 against visceral leishmaniasis.
This article is protected by copyright. All rights reserved. PMID: 30285279 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - October 4, 2018 Category: Allergy & Immunology Authors: He J, Huang F, Zhang J, Chen H, Chen Q, Zhang J, Li J, Zheng Z, Chen J, Chen D Tags: Immunology Source Type: research

Regulatory T-cells: receptors, repertoires and roles in disease.
Abstract In the 20-or-so years that immunologists have spent describing the mechanisms and functions of regulatory T-cells, a very great deal has been learnt: a T-cell subset once described for the generic ability to harness autoimmunity in vivo or diminish T-cell proliferation in vitro is now appreciated to act on a plethora of cellular pathways using a diverse array of mechanisms. Recent studies have shed new light on basic and applied aspects of Treg function, including T-cell receptor usage, specialist functions of tissue-resident Tregs, and the therapeutic consequences of tuning Treg function up or ...
Source: Immunology - September 19, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

Impact of sex hormones on immune function and MS development.
This article is protected by copyright. All rights reserved. PMID: 30222193 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - September 17, 2018 Category: Allergy & Immunology Authors: Ysrraelit MC, Correale J Tags: Immunology Source Type: research

VSIG-3 as a ligand of VISTA inhibits human T cell function.
This article is protected by copyright. All rights reserved. PMID: 30220083 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - September 16, 2018 Category: Allergy & Immunology Authors: Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V Tags: Immunology Source Type: research

Screening the full leukocyte receptor complex (LRC) region revealed associations with pemphigus that might be explained by gene regulation.
Abstract Pemphigus foliaceus (PF) is a blistering autoimmune skin disease rare in most of the world but endemic in certain regions of Brazil. PF is characterized by the detachment of epidermal cells and the presence of autoantibodies against desmoglein 1. In previous studies, we have shown that genetic polymorphisms and variable expression levels of certain leukocyte receptor complex (LRC) genes were associated with PF. However, the role of the LRC on PF susceptibility remained to be investigated. Here, we analyzed 527 tag single nucleotide polymorphisms (SNP) distributed within the 1.5 Mb LRC. After quality contr...
Source: Immunology - September 14, 2018 Category: Allergy & Immunology Authors: Della Justina Farias T, Augusto DG, de Almeida RC, Malheiros D, Petzl-Erler ML Tags: Immunology Source Type: research

The essential role of complement in antibody-mediated resistance to Salmonella.
This article is protected by copyright. All rights reserved. PMID: 30179254 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - September 4, 2018 Category: Allergy & Immunology Authors: Rossi O, Coward C, Goh YS, Claassens JWC, MacLennan CA, Verbeek SJ, Mastroeni P Tags: Immunology Source Type: research

Corrigendum.
Authors: PMID: 30178537 [PubMed - in process] (Source: Immunology)
Source: Immunology - September 1, 2018 Category: Allergy & Immunology Tags: Immunology Source Type: research

Bioinformatics for immunologists.
Abstract Immunology was once a specialty prone to cause dismay or even scepticism among outsiders for its struggles to visualize poorly understood, complex interactions through descriptive models integrating cell types, their factors and functions. This was the age of 'too many soft ideas propped up by too little hard data'. Twenty-first century immunologists have the advantage of being able to marry this rich conceptual legacy to a contemporary toolkit offering such depth of hard data across different 'omics' platforms, that they are faced by the opposite dilemma: 'too much hard data to comprehend or synthesize i...
Source: Immunology - September 1, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

Deceleration of glycometabolism impedes IgG-producing B cell-mediated tumor elimination by targeting SATB1.
This article is protected by copyright. All rights reserved. PMID: 30171602 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - September 1, 2018 Category: Allergy & Immunology Authors: Liu J, Li Y, Lu Z, Gu J, Liang Y, Huang E, Wang Z, Zhang H, Wang L, Zhang D, Yu H, Liu R, Chu Y Tags: Immunology Source Type: research

Immune signaling by supramolecular assemblies.
This article is protected by copyright. All rights reserved. PMID: 30144032 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 24, 2018 Category: Allergy & Immunology Authors: Kumar S, Jain S Tags: Immunology Source Type: research

γδ T cells modulate humoral immunity against Plasmodium berghei infection.
This article is protected by copyright. All rights reserved. PMID: 30144035 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 24, 2018 Category: Allergy & Immunology Authors: Inoue SI, Niikura M, Asahi H, Kawakami Y, Kobayashi F Tags: Immunology Source Type: research

mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.
This article is protected by copyright. All rights reserved. PMID: 30144045 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 24, 2018 Category: Allergy & Immunology Authors: Meena NK, Pattanayak SP, Ben-Nun Y, Benhamron S, Kumar S, Merquiol E, Hövelmeyer N, Blum G, Tirosh B Tags: Immunology Source Type: research

MicroRNA-mediated Regulation of Th17/Treg Balance in Autoimmune Disease.
This article is protected by copyright. All rights reserved. PMID: 30133700 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 22, 2018 Category: Allergy & Immunology Authors: Liu C, Yang H, Shi W, Wang T, Ruan Q Tags: Immunology Source Type: research

Interleukin 17-producing γδ T (γδ17) cells in inflammatory diseases.
This article is protected by copyright. All rights reserved. PMID: 30133701 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 22, 2018 Category: Allergy & Immunology Authors: Akitsu A, Iwakura Y Tags: Immunology Source Type: research

Human CD8 T cell activation in acute and chronic Chikungunya infection.
This article is protected by copyright. All rights reserved. PMID: 30099739 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 12, 2018 Category: Allergy & Immunology Authors: de Sousa Dias CN, Gois BM, Lima VS, Guerra-Gomes IC, Araújo JMG, de Assis Silva Gomes J, de Araújo DAM, de Medeiros IA, de Lourdes Assunção Araújo de Azevedo F, Veras RC, Janebro DI, do Amaral IPG, Keesen TSL Tags: Immunology Source Type: research

The inflammasomes, Immune guardians at defence barriers.
This article is protected by copyright. All rights reserved. PMID: 30098204 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 11, 2018 Category: Allergy & Immunology Authors: Palazon-Riquelme P, Lopez-Castejon G Tags: Immunology Source Type: research

The impact of inflationary CMV-specific memory T cells on anti-tumour immune responses in patients with cancer.
This article is protected by copyright. All rights reserved. PMID: 30098205 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 11, 2018 Category: Allergy & Immunology Authors: Luo XH, Meng Q, Rao M, Liu Z, Paraschoudi G, Dodoo E, Maeurer M Tags: Immunology Source Type: research

IL-33 contributes to disease severity in Dengue virus infection in mice.
This article is protected by copyright. All rights reserved. PMID: 30098206 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 11, 2018 Category: Allergy & Immunology Authors: Marques RE, Besnard AG, Maillet I, Fagundes CT, Souza DG, Ryffel B, Teixeira MM, Liew FY, Guabiraba R Tags: Immunology Source Type: research

YY1 Binds to the E3' Enhancer and Inhibits the Expression of the Immunoglobulin Kappa Gene via Epigenetic Modifications.
This article is protected by copyright. All rights reserved. PMID: 30098214 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - August 11, 2018 Category: Allergy & Immunology Authors: Zhou X, Xian W, Zhang J, Zhu Y, Shao X, Han Y, Qi Y, Ding X, Wang X Tags: Immunology Source Type: research

NK cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii.
This article is protected by copyright. All rights reserved. PMID: 30030839 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 20, 2018 Category: Allergy & Immunology Authors: Ferreira LS, Portuondo DL, Polesi MC, Carlos IZ Tags: Immunology Source Type: research

Development of a novel clustering tool for linear peptide sequences.
This article is protected by copyright. All rights reserved. PMID: 30014462 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 17, 2018 Category: Allergy & Immunology Authors: Dhanda SK, Vaughan K, Schulten V, Grifoni A, Weiskopf D, Sidney J, Peters B, Sette A Tags: Immunology Source Type: research

T cell subset differentiation and antibody responses following antiretroviral therapy during SIV infection.
This article is protected by copyright. All rights reserved. PMID: 30014618 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 17, 2018 Category: Allergy & Immunology Authors: Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P Tags: Immunology Source Type: research

Regulatory T cells control epitope spreading in autoimmune arthritis independent of CTLA-4.
This article is protected by copyright. All rights reserved. PMID: 29992549 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 10, 2018 Category: Allergy & Immunology Authors: Yang M, Klocke K, Marquina Hernandez C, Xu B, Gjertsson I, Wing K, Holmdahl R Tags: Immunology Source Type: research

Characterising a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.
This article is protected by copyright. All rights reserved. PMID: 29981529 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 7, 2018 Category: Allergy & Immunology Authors: Zelek WM, Stott M, Walters D, Harris CL, Morgan BP Tags: Immunology Source Type: research

Low molecule mass hyaluronan induces pulmonary inflammation by up-regulation of Mcl-1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway.
This article is protected by copyright. All rights reserved. PMID: 29975419 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 5, 2018 Category: Allergy & Immunology Authors: Zhao H, Ma Y, Zhang L Tags: Immunology Source Type: research

Local exchange of metabolites shapes immunity.
This article is protected by copyright. All rights reserved. PMID: 29972686 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Richter FC, Obba S, Simon AK Tags: Immunology Source Type: research

Evaluation of the immune response against Trypanosoma cruzi cytosolic Tryparedoxin Peroxidase in human natural infection.
This article is protected by copyright. All rights reserved. PMID: 29972690 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Girard MC, Acevedo GR, López L, Ossowski MS, Piñeyro MD, Grosso JP, Fernandez M, Hernández Vasquez Y, Robello C, Gómez KA Tags: Immunology Source Type: research

Interleukin-6 signaling mediates Galectin-8 costimulatory activity of antigen-specific CD4 T cell response.
This article is protected by copyright. All rights reserved. PMID: 29972692 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Carabelli J, Prato CA, Sanmarco LM, Aoki MP, Campetella O, Tribulatti MV Tags: Immunology Source Type: research

Peyer's patches-derived CD11b+ B cells recruit regulatory T cells through CXCL9 in DSS-induced colitis.
This study, based on the dextran sulfate sodium (DSS)-induced colitis model, revealed that Tregs are significantly increased in PPs, along with CD11b+ B cell induction. Immunofluorescence staining showed that infiltrated Tregs were located around CD11b+ B cells and produced TGF-β, thereby inducing IgA+ B cells. Furthermore, in vivo and in vitro studies revealed that CD11b+ B cells in PPs had the capacity to recruit Tregs into PPs rather than promoting their proliferation. Finally, we found that Treg recruitment was mediated by the chemokine CXCL9 derived from CD11b+ B cells in PPs. These findings demonstrate that CD11...
Source: Immunology - July 3, 2018 Category: Allergy & Immunology Authors: Wang Z, Zhang H, Liu R, Qian T, Liu J, Huang E, Lu Z, Zhao C, Wang L, Chu Y Tags: Immunology Source Type: research

Macrophage targeting: opening new possibilities for cancer immunotherapy.
This article is protected by copyright. All rights reserved. PMID: 29963704 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 2, 2018 Category: Allergy & Immunology Authors: Cassetta L, Kitamura T Tags: Immunology Source Type: research

New tools for MHC research from machine learning and predictive algorithms to the tumour immunopeptidome.
Abstract At a time when immunology seeks to progress ever more rapidly from characterization of a microbial or tumour antigen to the immune correlates that may define protective T-cell immunity, there is a need for robust tools to enable accurate predictions of peptide-major histocompatibility complex (pMHC) and peptide-MHC-T-cell receptor binding. Improvements in the curation of data sets from high throughput pMHC analysis, such as the NIH Immune Epitope Database (IEDB), and the associated developments of predictive tools rooted in machine-learning approaches, are having significant impact. When such approaches a...
Source: Immunology - June 15, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

The interaction between iNKT cells and the mucosal microbiota.
This article is protected by copyright. All rights reserved. PMID: 29893412 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - June 12, 2018 Category: Allergy & Immunology Authors: Hapil FZ, Wingender G Tags: Immunology Source Type: research

TLR4 signaling regulates antibody response to adenoviral vector-based vaccines by imprinting germinal center quality.
This article is protected by copyright. All rights reserved. PMID: 29876918 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - June 7, 2018 Category: Allergy & Immunology Authors: Li R, Liu J, Wu S, Zai X, Li Y, Yang Q, Hou L, Xu J, Chen W Tags: Immunology Source Type: research

Neuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease.
Abstract An ever-increasing collection of neurological human diseases are becoming appreciated as encompassing a strong immunological component in pathogenesis or regulation. This derives to a large extent from genome-wide association studies that have highlighted association with immune system genes, including those in the HLA and KIR regions. Along with the genomic findings have come insights from immune phenotyping and assays for autoimmunity. This is a group of disease processes that includes Parkinson's disease, Alzheimer's, stroke, narcolepsy, schizophrenia and psychosis. In most cases, these are diseases in...
Source: Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Altmann DM Tags: Immunology Source Type: research

ImmTAC/Anti-PD-1 Combination to Enhance Killing of Cancer cells by Reversing Treg-mediated Immunosuppression.
This article is protected by copyright. All rights reserved. PMID: 29791021 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 23, 2018 Category: Allergy & Immunology Authors: Zhang H, Li Y, Liu X, Liang Z, Yan M, Liu Q, Chen A, Bao Y, Zhou C, Li S, Yee C, Li Y Tags: Immunology Source Type: research

Helper T-Cell Responses and Pulmonary Fungal Infections.
This article is protected by copyright. All rights reserved. PMID: 29781185 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 20, 2018 Category: Allergy & Immunology Authors: McDermott AJ, Klein BS Tags: Immunology Source Type: research

Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity.
This article is protected by copyright. All rights reserved. PMID: 29771448 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Flannigan KL, Denning TL Tags: Immunology Source Type: research

Nature of tumor rejection antigens in ovarian cancer.
This article is protected by copyright. All rights reserved. PMID: 29772069 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Want MY, Lugade AA, Battaglia S, Odunsi K Tags: Immunology Source Type: research

CD6 mAbs differ in epitope, kinetics and mechanism of action.
This article is protected by copyright. All rights reserved. PMID: 29772075 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - May 17, 2018 Category: Allergy & Immunology Authors: Garner LI, Hartland A, Breuning J, Brown MH Tags: Immunology Source Type: research