Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit.
In this study, first, we have cloned the mouse cDNAs encoding for the δ, α1, β2 subunits of GABAARs, and then developed two fusion proteins of δ subunit each tagged with the GFP variant, EGFP (enhanced GFP) at unique sites in the cytoplasmic domain. The recombinant proteins were expressed alone or in combination with α1 and/or β2 subunits in neuroblastoma 2a cells. Live cell confocal microscopy indicated that the cytoplasmically tagged δ subunits were targeted to the cell membrane when expressed in the presence of α1 and β2 subunits in neuroblastoma 2a cells. However, this...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Oflaz FE, Son ÇD, Arslan A Tags: J Integr Neurosci Source Type: research

Real time large scale in vivo observations reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord.
Abstract How axons are wiring the vertebrate spinal cord has in particular been studied at the ventral floor plate using fixed samples or looking at single growing axons with various microscopy techniques. Thereby may remain hidden important live organismal scale information concerning dynamics and concurrent timing of the many axons simultaneously crossing the floor plate. Here then, applying light-sheet microscopy, axonal growth and guidance at the floor plate are followed in vivo in real time at high resolution along several hundred micrometers of the zebrafish spinal cord by using an interneuron expressing GFP...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Andersen SSL Tags: J Integr Neurosci Source Type: research

Bioinformatics analysis of the molecular mechanism underlying Huntington's disease.
Abstract We explore the underlying molecular mechanisms and to identify key molecules in Huntington's disease by utilizing bioinformatics methods. The gene expression profile of GSE3621 was extracted from the gene expression omnibus. Differentially expressed genes between the R6/1 transgenic mouse model of Huntington's disease and controls at different time points were screened by limma package in R. Kyoto encyclopedia of genes and genomes database. It was used to analyze the pathways of differentially expressed genes. A searching tool of the protein-protein interaction network was constructed and visualized by Cy...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Wang Z, Dong X, Cong S Tags: J Integr Neurosci Source Type: research

Efficacy of remote limb ischemic conditioning on poststroke cognitive impairment.
Abstract The impact of remote limb ischemic conditioning on poststroke cognitive impairment was evaluated with 104 first-time patients of noncardiac ischemic stroke. During the acute phase the patients were randomized into control and remote limb ischemic conditioning groups. Both groups received standard treatment, while the remote limb ischemic conditioning group received additional remote limb ischemic conditioning treatment for 6 months. All participants underwent neuropsychological evaluation, transcranial Doppler detection, P300 event-related potential and brachial-ankle pulse wave velocity measurements, and...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Feng X, Huang L, Wang Z, Wang L, Du X, Wang Q, Xue S Tags: J Integr Neurosci Source Type: research

The glutamatergic system and astrocytic impairment in rat hippocampus: a comparative study of underlying etiology and pathophysiology of depression.
Abstract Correlations amongst the rat glutamatergic system, glia, and depression, as well as the underlying mechanism of astrocyte impairment, as a trigger of depression, were investigated. Rats were submitted to different durations of chronic unpredictable mild stress to induce depressive-like behavior and evaluated by weight change, sucrose preference test, open field test, and novelty suppressed feeding test. High-performance liquid chromatography was employed to detect glutamate content of hippocampal protein expression during Western blot and immunofluorescence. Results showed that 21-day chronic unpredictabl...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Jiang S, Zhang QA, Guo Q, Di Z Tags: J Integr Neurosci Source Type: research

Contrasting effects of acute and long-term corticosterone treatment on amyloid- β, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation.
Contrasting effects of acute and long-term corticosterone treatment on amyloid-β, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation. J Integr Neurosci. 2019 Dec 30;18(4):393-400 Authors: Hou Y, Luo S, Zhang Y, Jia Y, Li H, Xiao C, Bao H, Du J Abstract Regulation of neuroinflammation is critical to control the detrimental impact of chronic stress in the central nervous system. Neuroinflammation occurs in response to chronic stress, leading to enhanced neuronal damage in the brain. We investigated the regulatory effects of stress hormone corticosterone on neuroinflammati...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Hou Y, Luo S, Zhang Y, Jia Y, Li H, Xiao C, Bao H, Du J Tags: J Integr Neurosci Source Type: research

A novel squaramide compound alleviates cognitive deficits through activation of Akt and Erk1/2 in a rat model of vascular dementia.
Abstract Vascular dementia is the second most common type of dementia, yet no effective treatment for it exists. Akt and Erk1/2 signaling pathways are involved in neuronal survival. It has been reported that bisperoxovanadium (pyridin-2-squaramide), a novel squaramide compound, protects against cerebral ischemia injury via activation of Akt and Erk1/2. Here, the potential neuroprotective effect of bisperoxovanadium is shown for the first time in a model of vascular dementia induced in 6-month-old male Sprague-Dawley rats by two-vessel occlusion injury applied to 6-month-old. Following this lesion, bisperoxovanadiu...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Yuan M, Zhu H, Chen J, Zhao D, Wan Q, Zhang Z Tags: J Integr Neurosci Source Type: research

Purkinje cells of vestibulocerebellum play an important role in acute vestibular migraine.
Abstract Both the central and peripheral vestibular systems contribute to the pathogenesis of vestibular migraine, although the mechanism of vestibular migraine remains unclear. To assess central and peripheral vestibular system damage in vestibular migraine and explore the underlying mechanism we performed vestibular function tests, including a caloric test, spontaneous, gaze-evoked nystagmus and saccadic, pursuit and optokinetic eye movements to evaluate the involvement of the central and/or peripheral vestibular system in subjects with acute vestibular migraine episodes. It was found that both peripheral and ce...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Li P, Gu H, Xu J, Zhang Z, Li F, Feng M, Tian Q, Shang C, Zhuang J Tags: J Integr Neurosci Source Type: research

Effect of incubation with lipopolysaccharide and interferon- γ on reactive astrogliosis.
Effect of incubation with lipopolysaccharide and interferon-γ on reactive astrogliosis. J Integr Neurosci. 2019 Dec 30;18(4):415-421 Authors: Hua X, Wang Y, Yang C, Chai R, Li X, Tayier G, Pan P, Yu X Abstract Sepsis associated encephalopathy is a common complication of sepsis, but its pathogenesis of sepsis-associated encephalopathy remains unclear. Astrocytes are the most abundant brain glial cells, and reactive astrogliosis, a pathological response to central nervous system diseases, has a clear disease and disease-stage specificity. Functional changes of astrocytes are of great significance ...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Hua X, Wang Y, Yang C, Chai R, Li X, Tayier G, Pan P, Yu X Tags: J Integr Neurosci Source Type: research

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson's disease rats via the mTOR/AKT/GSK-3 β pathway.
Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson's disease rats via the mTOR/AKT/GSK-3β pathway. J Integr Neurosci. 2019 Dec 30;18(4):423-429 Authors: Zhai H, Kang Z, Zhang H, Ma J, Chen G Abstract This focus of our research is to investigate the protective effect of Baicalin on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in a rat model for Parkinson's disease, induced by 6-Hydroxydopamine. Thirty healthy female Sprague-Dawley rats were randomly divided into control group, model group, and Baicalin group. The Parkinson model was established by inject...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Zhai H, Kang Z, Zhang H, Ma J, Chen G Tags: J Integr Neurosci Source Type: research

Long noncoding RNA-regulator of reprogramming alleviates hypoxia-induced cerebral injury in mice model and human via modulating apoptosis complexes.
Abstract Ischemic stroke causes cerebral hypoxia, while long non-coding RNA regulator of reprogramming is associated with hypoxia. To find a new intervention target to protect hypoxic cerebral tissue and a potential biomarker from reflecting the severity of hypoxia after ischemic stroke, our research explored the expression pattern and function of the regulator of reprogramming in cerebral hypoxia-induced injury. The expression pattern and the function of the regulator of reprogramming were explored in mice with middle cerebral artery occlusion, and human brain microvascular endothelial cells underwent oxygen-gluc...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Zhou Q, An Y, Tang Y Tags: J Integr Neurosci Source Type: research

Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment.
Abstract The effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment were investigated, and the related mechanisms explored. Male C57BL/6 mice were randomly divided into four groups: environment control, sleep deprivation control, sleep-deprived-plasmid adeno-associated virus-green fluorescent protein group, and sleep-deprived-plasmid adeno-associated virus-cellular prion protein-green fluorescent protein group. Overexpression of cellular prion protein was induced by stereotaxic injection of adeno-associated viral plasmids-CAG-enhanced green fluorescent protein-c...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Hu L, Li P, You Z, Zhang Z, Jin H, Huang L Tags: J Integr Neurosci Source Type: research

Diphenyleneiodonium chloride synergizes with diazoxide to enhance protection against amyloid β induced neurotoxicity.
In conclusion, the activation of a mitochondrial potassium channel in combination with the inhibitor of nicotinamide adenine dinucleotide phosphate oxidase exhibit synergistic protective effects against amyloid β neurotoxicity. PMID: 31912704 [PubMed - in process] (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Fu Q, Gao N, Che F, Xu G, Han H, Su Q, Ma G Tags: J Integr Neurosci Source Type: research

Effects of aminooxyacetic acid on hippocampal mitochondria in rats with chronic alcoholism: the analysis of learning and memory-related genes.
Abstract The incidence of chronic alcoholism leading to central and peripheral nervous system damage has been increasing year-to-year. The purpose of this study is to explore the effects of aminooxyacetic acid on hippocampus mitochondria in rats with chronic alcoholism and analyze learning and memory-related genes. Sixty male Sprague Dawley rats were randomly divided into three groups. Except for the control group, each group was fed with the water containing (v/v) 6% alcohol for 28 days. After 14 days, rats in the treatment group were intraperitoneally injected daily for 14 days with aminooxyacetic acid. High thr...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Du A, Dai X, Dong J, Liu J, Zhang Y, Fu P, Qin H, Li R, Zhang R Tags: J Integr Neurosci Source Type: research

Migraine-linked characteristics of transcranial magnetic stimulation-induced phosphenes.
nė K Abstract Transcranial magnetic stimulation is used to explore visual cortex hyperexcitability in migraine. We hypothesized that the phosphene threshold in subjects suffering from migraines with and without aura would be lower than in controls, and this phenomenon could be linked to higher pain and disability levels. We also implied that subjects with lower phosphene threshold could see more phosphenes of different colors and shapes. Our primary objective was to compare the phosphene threshold between migraine without aura, migraine with aura, and control groups and investigate which factors contribute to dif...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Ekkert A, Noreikaitė K, Valiulis V, Ryliškienė K Tags: J Integr Neurosci Source Type: research

Investigation for the correlation between brain injury and injured ipsilateral sciatic nerve regeneration in a rat model.
Abstract Previous studies showed that brain trauma promotes repair of peripheral nerve injury by reducing scar in nerve endings. The effect of brain injury at different locations on ipsilateral rat sciatic nerve regeneration in Sprague-Dawley rats was found to promote the repair of ipsilateral sciatic nerve injury, thus providing further experimental evidence for the unveiling of traumatic brain injury promoting peripheral nerve regeneration. PMID: 31912707 [PubMed - in process] (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Wang H, Ma J, He X, Xie Q, Fu Y, Wang P Tags: J Integr Neurosci Source Type: research

Evaluation of changes in magnetic resonance diffusion tensor imaging after treatment of delayed encephalopathy due to carbon monoxide poisoning.
Abstract Diffusion tensor imaging of the brain tissue microstructure was performed to predict or diagnose the pathophysiological mechanism underlying delayed encephalopathy after carbon monoxide poisoning and the treatment effect was analyzed. The changes in the diffusion parameters (average diffusion coefficient and fractional anisotropy) in adult patients after hyperbaric oxygen therapy of delayed encephalopathy after carbon monoxide poisoning were not significant differences of the two lateral ventricles or anterior or posterior limb of the internal capsule. In the group exposed to hyperbaric oxygen therapy, th...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Wu J, Peng T, Xu Z, Yang X, Zhao L, Yang H, Zhao D Tags: J Integr Neurosci Source Type: research

Respiratory rhythm generation and pattern formation: oscillators and network mechanisms.
Abstract The respiratory rhythm is generated by the interaction of oscillators disparately distributed throughout the pons, medulla, and spinal cord. According to the classic model, the interaction amongst preBötzinger complex (preBötzC) spontaneously bursting preinspiratory units and Bötzinger complex (BötzC) expiratory cells generates the principal respiratory rhythm, thence relayed caudally to the pattern generating elements and premotoneurons of the rostral and caudal divisions of the ventral respiratory group and bulbospinal units of the dorsal respiratory group. Rhythm and pattern generat...
Source: Journal of Integrative Neuroscience - December 30, 2019 Category: Neuroscience Authors: Ghali MGZ Tags: J Integr Neurosci Source Type: research

Automatic eye blink artifact removal for EEG based on a sparse coding technique for assessing major mental disorders.
In this study, the proposed method has been tested and validated with five different datasets for artifact detection and correction. Results show that the proposed technique is promising as it successfully extracted the exact locations of eye blinking artifacts. The accuracy of the method (automatic detection) is 89.6% which represents a better estimate than that obtained by an extreme machine learning classifier. PMID: 31601069 [PubMed - in process] (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Zafar R, Qayyum A, Mumtaz W Tags: J Integr Neurosci Source Type: research

Neuroanatomical correlates of trait gambling-related cognitive distortions.
Abstract Abundant evidence suggests that gambling-related cognitive distortions play a crucial role in disruptive gambling behavior. However, to date, there have been few efforts to address the neuroanatomical basis of inter-individual differences in trait gambling-related cognitive distortions. We applied voxel-based morphometry to explore the neuroanatomical correlates of trait gambling-related cognitive distortions by correlating regional gray matter volume with behavioral scores tested by the gambling attitudes and beliefs survey. The results show that individuals with a higher degree of gambling-related cogni...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Lu H, Kong X, Kong F Tags: J Integr Neurosci Source Type: research

Effects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats.
Abstract Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a treatment option for depression and anxiety. However, its role in epilepsy comorbid with depression and anxiety is unclear. Therefore, we evaluated whether low-frequency rTMS can alleviate depression- and anxiety-like behavior in epileptic rats. Forty-eight adult rats were allocated at random to four groups: Control, Pentylenetetrazol (PTZ), PTZ-rTMS and PTZ-Sham. The control group received intraperitoneal injections of normal saline, while the other groups received intraperitoneal injections of pentylenetetrazol (3...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Wang S, Mao S, Yao B, Xiang D, Fang C Tags: J Integr Neurosci Source Type: research

The therapeutic effect of quetiapine on cognitive impairment associated with 5-HT1A presynaptic receptor involved schizophrenia.
Abstract The cognitive impairment associated with schizophrenia is highly prevalent and affects the overall functioning of subjects. The stimulation of the serotonin 1A receptor is a primary characteristic of some atypical antipsychotic drugs. We measured the levels of cognitive impairment using the Morris water maze test and protein kinase A activity in hippocampal neurons on presynaptic and postsynaptic serotonin 1A receptors to investigate the effect of dizocilpine-induced cognitive impairment associated with atypical antipsychotic drugs in rats treated by quetiapine alone or combined with WAY100635/tandospiron...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Han D, Shi S, Luo H Tags: J Integr Neurosci Source Type: research

fNIRS correlates of the development of inhibitory control in young obese subjects.
Abstract Executive functions are closely related to the prefrontal cortex, and inhibitory control is an important component of executive functioning. Previous studies have found that inhibitory control continues to develop after adolescence and that obesity is associated with executive functions. However, few studies have addressed whether obesity affects the development of inhibitory control. Hence, we focused on whether inhibitory control continues to develop after adolescence in obese individuals. We used a Stroop task to measure the inhibitory control of young obese subjects, and monitored accompanying brain a...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Huang J, Xiong M, Xiao X, Xu X, Hong X Tags: J Integr Neurosci Source Type: research

Instantaneous fMRI based cerebral parameters for automatic Alzheimer, mild cognitive impairment and healthy subject classification.
Abstract Automatic identification and categorization of Alzheimer's patients and the ability to distinguish between different levels of this disease would be very helpful to the research community studying this disease since non-automatic approaches are both very time-consuming and highly dependent upon the experience of experts. Here, it is proposed that instantaneous cerebral phase and envelope information from functional magnetic resonance imaging data is of use to discriminate between Alzheimer's patients, mild cognitively impaired subjects and healthy individuals. Following a region-of-interest analysis of fu...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Seraj E, Yazdi M, Shahparian N Tags: J Integr Neurosci Source Type: research

Contingent negative variation for the periodicity of migraine attacks without aura.
Abstract Migraine is a primary neuropsychological disorder, although its etiology and pathogenesis are unknown. It has been reported that using contingent negative variation, the periodicity of migraine attacks is three days in adults. However, there is still a lack of relevant reports about the periodicity of migraine without aura in adults. Therefore, we investigated the changes of contingent negative variation in adults with migraine without aura from three to seven days after migraine attacks in order to provide the basis for exploring the circulation periodicity of migraine without aura. This prospective, obs...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Tian Q, Xu S, Guo Y, Li J, Han M, Ma Y, Hou X, Chen J, Luo D, Hong Y, Nie S, Liu X Tags: J Integr Neurosci Source Type: research

Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum.
Abstract Rats were divided into six groups: sham/control , Dl-3-n-butylphthalide, P1 (low phenytoin, 100 mg/kg), P2 (high phenytoin, 200 mg/kg), NP1 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 100 mg/kg), NP2 (Dl-3-n-butylphthalide 80 mg/kg, phenytoin 200 mg/kg). Hematoxylin/eosin and Nissl staining showed that, compared to the sham/control group, the Dl-3-n-butylphthalide group had no obvious hippocampal and cerebellar neuron loss, but there was a significant neuron loss in the P1 and P2 groups (P
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Chen J, Liu N, Wang X, Zhao Y, He J, Yang L, Sun Q, Zhao J, Wang L, Chen L Tags: J Integr Neurosci Source Type: research

MiR-361-3p inhibits β-amyloid accumulation and attenuates cognitive deficits through targeting BACE1 in Alzheimer's disease.
MiR-361-3p inhibits β-amyloid accumulation and attenuates cognitive deficits through targeting BACE1 in Alzheimer's disease. J Integr Neurosci. 2019 Sep 30;18(3):285-291 Authors: Ji Y, Wang D, Zhang B, Lu H Abstract The role of miR-361-3p in the pathology of Alzheimer's disease is unknown. The target scan was used to screen potential target genes of miR-361-3p, and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) was emphasized. Results from western blotting and reverse transcription-quantitative polymerase chain reaction (RT-PCR) showed that down-regulated miR-361-3p was cor...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Ji Y, Wang D, Zhang B, Lu H Tags: J Integr Neurosci Source Type: research

Statistical algorithms for emotion classification via functional connectivity.
Abstract Pattern recognition algorithms decode emotional brain states by using functional connectivity measures which are extracted from EEG signals as input to the statistical classifiers. An open-access EEG dataset for emotional state analysis is used to classify two dominant emotional models, based on valence and arousal. To calculate the functional connectivity between all available pairs of EEG electrodes four different measures, including Pearson's correlation coefficient, phase-locking value, mutual information, and magnitude square coherence estimation, were used. Three kinds of classifiers were applied to...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Jahromy FZ, Bajoulvand A, Daliri MR Tags: J Integr Neurosci Source Type: research

Superoxide dismutase coding of gene polymorphisms associated with susceptibility to Parkinson's disease.
This study assessed the potential associations of gene polymorphisms in SOD1 (encoding Cu/Zn-SOD), SOD2 (encoding Mn-SOD) and SOD3 (encoding extracellular-SOD) with susceptibility to Parkinson's disease. A case-control study, including Parkinson's disease cases (n = 356) and controls (n = 370). Single nucleotide polymorphisms of SOD1 (rs2070424 A/G), SOD2 (rs4880 T/C) and SOD3 (rs1799895, C/G) were genotyped. Results indicated that AG or GG genotype carriers in SOD1 had a much greater risk of Parkinson's disease compared to corresponding AA genotypes, and allele G carriers had increased risk versus allele A carriers in the...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Liu C, Fang J, Liu W Tags: J Integr Neurosci Source Type: research

Utilization of electromyography during selective obturator neurotomy to treat spastic cerebral palsy accompanied by scissors gait.
Abstract Selective obturator neurotomy is a commonly used neurosurgical intervention for spastic cerebral palsy with scissors gait. Here we report the use of surface electromyography to assess the accuracy and effect of selective obturator neurotomy procedures. Selective obturator neurotomy was carried out on 18 patients while using intraoperative electromyography. Contractions of adductor muscles were recorded by electromyography before and after neurotomy and assessed using root mean square and integrated electromyography tests. Passive and voluntary movements were recorded for all patients. Our results show tha...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Ren S, Liu W, Wang L, Guo C, Pang Q Tags: J Integr Neurosci Source Type: research

The Wnt/ β-catenin signaling pathway affects the distribution of cytoskeletal proteins in Aβ treated PC12 cells.
This study is focused on the Wnt/β-catenin pathway influence on Tau phosphorylation and the distribution of microtubules and neurofilaments in adrenal pheochromocytoma cells. It was found that neurofilament heavy polypeptide and microtubule-associated protein-2 aggregated after treatment with Aβ₁₋₄₂. Treatment with Wnt5a reduced this aggregation, while Dickkopf-1 treatment promoted microtubule and neurofilament aggregation. Furthermore, Tau phosphorylation at Ser396, Ser422, and Ser199 was significantly reduced after Wnt5a treatment, whereas Dickkopf-1 increased the level of phosphorylation. These results...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Tian Z, Zhang X, Zhao Z, Zhang F, Deng T Tags: J Integr Neurosci Source Type: research

Mechanisms contributing to the genesis of hypoglossal preinspiratory discharge.
Abstract Preinspiratory discharge manifests in the neuronal recordings of the pre-Bötzinger complex, parafacial respiratory group, retrotrapezoid nucleus, and Kölliker-Fuse nucleus, as well as the efferent neural discharge of respiratory-related nerves innervating upper airway musculature. This neural component of triphasic eupnea contemporaneously contributes to the genesis of native and originate respiratory rhythmic activity, as well as the preinspiratory component of efferent neural respiratory discharges. In the course of our investigations evaluating hypoglossal discharge in response to asphyxia, w...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Ghali MGZ Tags: J Integr Neurosci Source Type: research

Current anti-Alzheimer's disease effect of natural products and their principal targets.
Abstract Various bioactive substances isolated from natural products play a pivotal role in the prevention and cure of neurodegenerative diseases, such as Alzheimer's disease. Currently, there are many theories about the pathogenesis of this disease. In this review we discuss among them, the cholinergic hypotheses, the Aβ toxicity hypothesis, and the tau dysfunction hypothesis. Multiple potential targets are a focus for the development of anti-AD drugs. There is an urgent need to develop more effective therapies to treat and delay the onset of the disease and to find safe and effective drugs. In this review, ...
Source: Journal of Integrative Neuroscience - September 30, 2019 Category: Neuroscience Authors: Zhu Y, Peng L, Hu J, Chen Y, Chen F Tags: J Integr Neurosci Source Type: research

Whole brain and corpus callosum diffusion tensor metrics: How do they correlate with visual and verbal memory performance in chronic traumatic brain injury.
Abstract This research investigates the chronic effect of moderate to severe traumatic brain injury on brain white matter integrity, as reflected by diffusion tensor imaging metrics, and the assessment of their correlation to neuropsychological response. Thirteen male participants with traumatic brain injury (8.4 years average post-injury time) were compared to a matched group of neurologically healthy controls. None of the traumatic brain injury subjects had received post-acute neurocognitive and/or neuropsychological rehabilitation. Between-group comparison of fractional anisotropy, mean diffusivity, axial diffu...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Yiannakkaras C, Konstantinou N, Constantinidou F, Pettemeridou E, Eracleous E, Papacostas SS, Seimenis I Tags: J Integr Neurosci Source Type: research

Electrophysiological modulation and cognitive-verbal enhancement by multi-session Broca's stimulation: a quantitative EEG transcranial direct current stimulation based investigation.
Abstract To evaluate transcranial direct current stimulation-induced changes in resting state quantitative EEG and cognitiveverbal performance of second language learners, 16 healthy individuals were randomly recruited to sham and real transcranial direct current stimulation groups receiving eight sessions of second language instruction accompanied by a 2 mA transcranial direct current stimulation over Broca's area with the cathode placed over the left arm. Quantitative EEG was recorded during the resting state after the stimulation session and second language instruction. Reduced theta activity at Fp1, F7, F3, an...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Saadi ZK, Saadat M, Kamali AM, Yahyavi SS, Nami M Tags: J Integr Neurosci Source Type: research

MST1 suppresses viability and promotes apoptosis of glioma cells via upregulating SIRT6 expression.
Abstract It has been well established that mammalian sterile 20-like 1 (MST1) functions as a suppressor via regulating cell progression in many tumors. However, the molecular mechanism of MST1 on regulating glioma progression remains unclear. Here, we discovered that MST1 was robustly down-regulated in glioma tissues and cells. Functional analysis showed that over-expression of MST1 downregulated viability and colony formation and promoted apoptosis of glioma cells. Our results also identified that MST1 positively regulated expression of SIRT6 (Sirtuin 6) via transcriptional factor FOXO3a (Forkhead box O3a). Furth...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Zhu D, Sun C, Qian X Tags: J Integr Neurosci Source Type: research

Hippocampal neuron loss and astrogliosis in medial temporal lobe epileptic patients with mental disorders.
Abstract Hippocampal neuron loss and reactive astrogliosis are pathological features of medial temporal lobe epilepsy. Here, the expression of hippocampal astrogliosisassociated genes are studied in subjects with medial temporal lobe epilepsy and mental disorders (such as depression, anxiety and psychiatric comorbidities). The relationship between functional changes in hippocampus astrocytes and concurrent mental disorders are discussed. Nissl staining identified medial temporal lobe epilepsyinduced neuronal loss in the CA1 region of hippocampus. Quantitative real-time polymerase chain reaction and immunofluoresce...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Lu J, Huang H, Zeng Q, Zhang X, Xu M, Cai Y, Wang Q, Huang Y, Peng Q, Deng L Tags: J Integr Neurosci Source Type: research

Model for cascading failures in functional networks: application to epileptic patients with generalized tonic-clonic seizures.
Abstract The dynamic process of epilepsy is modeled as a cascading failure model in functional networks derived from graph theory. The aim is to test whether cascading failure identified from functional magnetic resonance imaging data could simulate epileptic discharges in 18 subjects with generalized tonic-clonic seizure and 17 demographically matched healthy controls. A cascading failure model was used to simulate the neural networks underlying generalized tonic-clonic seizure and healthy controls by stimulation of the node with the greatest number of connections. Results showed that the efficiency of generalize...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Ke M, Cao L, Liu G Tags: J Integr Neurosci Source Type: research

Channel selection in motor imaginary-based brain-computer interfaces: a particle swarm optimization algorithm.
Abstract The number of electrode channels in a brain-computer interface affects not only its classification performance, but also its convenience in practical applications. However, an effective method for determining the number of channels has not yet been established for motor imagerybased brain-computer interfaces. This paper proposes a novel evolutionary search algorithm, binary quantumbehaved particle swarm optimization, for channel selection, which is implemented in a wrapping manner, coupling common spatial pattern for feature extraction, and support vector machine for classification. The fitness function o...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Zhang L, Wei Q Tags: J Integr Neurosci Source Type: research

β-carotene provides neuro protection after experimental traumatic brain injury via the Nrf2-ARE pathway.
β-carotene provides neuro protection after experimental traumatic brain injury via the Nrf2-ARE pathway. J Integr Neurosci. 2019 Jun 30;18(2):153-161 Authors: Chen P, Li L, Gao Y, Xie Z, Zhang Y, Pan Z, Tu Y, Wang H, Han Q, Hu X, Xin X Abstract We investigate whether β-carotene, a known natural antioxidant, can reduce oxidative stress induced by traumatic brain injury. In addition, we investigated the underlying mechanism of traumatic brain injury focusing on the NF-E2-related factor (Nrf2) pathway. A controlled cortical impact model was used to mimic traumatic brain injury. Using this model...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Chen P, Li L, Gao Y, Xie Z, Zhang Y, Pan Z, Tu Y, Wang H, Han Q, Hu X, Xin X Tags: J Integr Neurosci Source Type: research

Modulation of NMDA-mediated intrinsic membrane properties of ascending commissural interneurons in neonatal rat spinal cord.
Abstract In this paper, the modulation of ascending commissural interneurons by N-methyl-D-aspartate was investigated in neonatal rats by using retrograde labeling and wholecell patch clamp. Data shows these interneurons can be divided into three types (single spike, phasic, and tonic) based on their firing patterns. A hyperpolarizationactivated nonselective cation current and persistent inward current are expressed in these interneurons. The parameters studied (n = 48) include: resting membrane potential (-59.2 ± 0.8 mV), input resistance (964.4 ± 49.3 MΩ), voltage threshold (-39.5 ± 0....
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Cheng Y, Ge R, Chen K, Dai Y Tags: J Integr Neurosci Source Type: research

Protein kinase C- ε contributes to a chronic inhibitory effect of IL-1β on voltage-gated sodium channels in mice with febrile seizure.
This study aimed to understand the role of Interleukin-1β in mouse febrile seizures. To investigate the chronic effects of raised Interleukin-1β on seizures, the sodium currents of hippocampal neurons were recorded by whole-cell voltage clamp. Interleukin-1β inhibited sodium currents in mouse hippocampal neurons and verified that protein kinase C epsilon contributed to the effect of Interleukin-1β exposure. The inhibitory effect was also identified in neurons from a protein kinase C epsilon null mutant mouse. Action potentials were recorded using a ramp depolarizing current. Peak spike depolarization wa...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Wang J, Xu F, Zheng Y, Cheng X, Zhang P, Zhao H Tags: J Integr Neurosci Source Type: research

The tripartite mechanism as the basis for a biochemical memory engram.
Abstract In this paper, we address the enigma of the memory engram, the physical trace of memory in terms of its composition, processes, and location. A neurochemical approach assumes that neural processes hinge on the same terms used to describe the biochemical functioning of other biological tissues and organs. We define a biochemical process, a tripartite mechanism involving the interactions of neurons with their neural extracellular matrix, trace metals, and neurotransmitters as the basis of a biochemical memory engram. The latter inextricably link physiological responses, including sensations with affective s...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Marx G, Gilon C Tags: J Integr Neurosci Source Type: research

Retrospecting atrial fibrillation and stroke severity: impact onset time of acute ischemic stroke.
Abstract Irrespective of the duration of the therapeutic window, the prognosis for acute ischemic stroke is closely correlated with the time of treatment initiation. Time from symptom onset to hospital arrival, defined as the onset time, is the determining parameter. Besides the prehospital transport, whether relative factors of illness may have an impact on stroke onset time is uncertain, which were invested in this study through statistical analyses. Results show that relative factors of illness, such as history of atrial fibrillation and stroke severity, impact stroke onset time. PMID: 31321960 [PubMed - i...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Luo Y, Li Z Tags: J Integr Neurosci Source Type: research

Minimally invasive puncture and drainage versus craniotomy: basal ganglia intracerebral hemorrhage in elderly patients.
This study aimed to compare the curative effects of these two procedures in such patients. A retrospective study of patients older than years with spontaneous intracerebral hemorrhage was conducted between January 2012 and December 2015. Of the 86 patients, 47 received minimally invasive puncture and drainage and 39 underwent craniotomy. One year after surgery no statistically significant difference was observed between the two groups with respect to: evacuation rate of the hematoma five days after the operation, volume of residual hematoma, occurrence of rebleeding, development of infectious meningitis, length of hospital...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Yang K, Zhang Y, Song J, Zhang X, Wan W Tags: J Integr Neurosci Source Type: research

Neuroacanthocytosis: a case report of chorea-acanthocytosis.
Abstract Neuroacanthocytosis is a rare progressive neurodegenerative disease, including Chorea-acanthocytosis, McLeod syndrome, Huntington's disease-like 2, and pantothenate kinase-associated neurodegeneration, where Choreaacanthocytosis occupies the main entity of this disease group. Here, a classic case of Chorea-acanthocytosis is reported that exhibited gradually deteriorating abnormal movements of limbs and face, swallowing difficulty, and lip and cheek biting for the past two years. Peripheral blood smears revealed that 35% of the red blood cells were acanthocytes and electron microcopy scans clearly showed t...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Xiang Y, Li S, Liu X, Li J, Sun Q, Chen Y, Du Y, Wu J Tags: J Integr Neurosci Source Type: research

Morphological and functional alterations of astrocytes responding to traumatic brain injury.
Abstract Astrocytes, one of the most abundant and heterogeneous types of glial cell in the brain and spinal cord, are responsible for various essential functions in the healthy central nervous system, including maintaining the blood brain barrier integrity, regulating neuron differentiation and supporting, nourishing, protecting, insulating and repairing neurons. They also fulfill a range of other homeostatic maintenance functions. Astrocytes are activated after traumatic brain injury. They then exhibit heterogeneous gene expression and changes in morphology, proliferative capacity and various functions in respons...
Source: Journal of Integrative Neuroscience - June 30, 2019 Category: Neuroscience Authors: Cheng X, Wang J, Sun X, Shao L, Guo Z, Li Y Tags: J Integr Neurosci Source Type: research

Theorizing how the brain encodes consciousness based on negentropic entanglement.
Abstract The physicality of subjectivity is explained through a theoretical conceptualization of guidance waves informing meaning in negentropically entangled non-electrolytic brain regions. Subjectivity manifests its influence at the microscopic scale of matter originating from de Broglie 'hidden' thermodynamics as action of guidance waves. The preconscious experienceability of subjectivity is associated with a nested hierarchy of microprocesses, which are actualized as a continuum of patterns of discrete atomic microfeels (or "qualia"). The mechanism is suggested to be through negentropic entanglement ...
Source: Journal of Integrative Neuroscience - March 30, 2019 Category: Neuroscience Authors: Poznanski RR, Cacha LA, Latif AZA, Salleh SH, Ali J, Yupapin P, Tuszynski JA, Tengku MA Tags: J Integr Neurosci Source Type: research

Variability in anterior insula grey matter volume correlates with awareness for peri-threshold backward-masked fearful faces.
This study hypothesized that there would be a positive correlation between insular grey matter volume and scores on the forced-choice awareness check task. The forced-choice awareness check task was designed to assess awareness for the presence and location of backward masked fearful and neutral faces, masked with neutral faces. The participants responded by indicating the side on which the masked fearful face appeared, or whether there were two neutral faces. The task included a total of 60 trials. T1-weighted magnetic resonance images were collected to measure grey matter volumes. Individuals that were more aware of back...
Source: Journal of Integrative Neuroscience - March 30, 2019 Category: Neuroscience Authors: Torrence RD, Davis JE, Troup LJ, Carlson JM Tags: J Integr Neurosci Source Type: research

MEG recordings of patients with cerebral palsy before and after the application of pico-Tesla weak magnetic fields.
Abstract MEG data for five cerebral palsy patients were taken using a whole-head 122-channel MEG system. An experiment was designed to identify the possible effect of external pico-Tesla weak magnetic fields. The subjects were five male volunteers 17-46 years of age. External stimulation, field amplitude 1-7.5 pico-Tesla, was applied to each subject at their alpha-rhythm frequency. Fast Fourier transforms were applied to the data of all MEG channels and the rhythms of the patients were evaluated before and after pico-Tesla transcranial magnetic stimulation. The appliance of pico-Tesla weak magnetic fields showed t...
Source: Journal of Integrative Neuroscience - March 30, 2019 Category: Neuroscience Authors: Anninos P, Kotini A, Adamopoulos A, Tsagas N Tags: J Integr Neurosci Source Type: research