Journal of Integrative Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Neural Mechanism Underlying Differentiated In-Group Versus Out-Group Face Recognition and Memory, Identification, Empathy and Pro-social Behavior: Evidence from fMRI and ERP Studies
J Integr Neurosci. 2024 Mar 1;23(3):48. doi: 10.31083/j.jin2303048.ABSTRACTIn the context of perceiving individuals within and outside of social groups, there are distinct cognitive processes and mechanisms in the brain. Extensive research in recent years has delved into the neural mechanisms that underlie differences in how we perceive individuals from different social groups. To gain a deeper understanding of these neural mechanisms, we present a comprehensive review from the perspectives of facial recognition and memory, intergroup identification, empathy, and pro-social behavior. Specifically, we focus on studies that ...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Kaizhen Peng Lili Tan Xiaomin Zhang Source Type: research

 CD6 and CCR7 as Genetic Biomarkers in Evaluating Intracranial Aneurysm Rupture Risk
CONCLUSIONS: The identified two-gene signature (CD6-CCR7) for evaluating the risk of IA rupture demonstrated good clinical application value.PMID:38538213 | DOI:10.31083/j.jin2303055 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Dan-Dan Xu Xiao-Qiang Liu Zhi-Sheng Wu Source Type: research

Fasting, a Potential Intervention in Alzheimer's Disease
J Integr Neurosci. 2024 Mar 4;23(3):50. doi: 10.31083/j.jin2303050.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder characterized by the onset of symptoms, typically occurring later in life, and significant deficits in cognitive functions including learning, memory, speech, and behavior. Ongoing research endeavors seek to explore methods for preventing and treating AD, as well as delving into the molecular mechanisms underlying existing and novel therapeutic approaches encompassing exercise, diet, and drug regimens for individuals with AD or those at risk of developing AD. Among these interventions, dietary...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Zhengzhong Zeng Hu Zhang Xianping Wang Jiawen Shen Danyang Chen Source Type: research

Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of DCC Signaling in a Rat Model of Bone Cancer Pain
CONCLUSIONS: Netrin-1 may contribute to the activation of the BCP by inducing nociceptive nerve innervation and improving pain behaviors.PMID:38538215 | DOI:10.31083/j.jin2303047 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Zhihao Gong Yuxin Zhang Wei Wang Xin Li Kai Wang Xingji You Jingxiang Wu Source Type: research

Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury
CONCLUSIONS: DNP facilitated the post-injury recovery in SCI rats via the inhibition of ferroptosis.PMID:38538216 | DOI:10.31083/j.jin2303065 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jian Huang Jianghong Luo Ying Huang Linghong Wang Haibing Zhu Zhengnan Li Jianping Chen Source Type: research

The Genetic Association of MMP-2 Gene Polymorphisms with the Susceptibility to Alzheimer's Disease
CONCLUSIONS: MMP-2 gene rs243866 and rs243865 polymorphisms were closely associated with the onset age of AD. The presence of rs243866 AA genotype emerged as a crucial predictor of AD risk.PMID:38538217 | DOI:10.31083/j.jin2303052 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Lina Liu Luran Liu Yunting Lu Tianyuan Zhang Wenting Zhao Source Type: research

Neuropeptides as Potential Biomarkers in Vascular Dementia
This article reviews recent advances in the involvement of neuropeptides in vascular dementia. Neuropeptides are present in the brain as chemical signals and last for nearly 50 years. Peptide hormones are chemical signals of the endocrine system. Thus, neuropeptides are the most diverse class of signaling molecules in the brain, involving the genomes of many mammals, encoding neuropeptide precursors and many bioactive neuropeptides. Here the aim is to describe the recent advances in classical neuropeptides, as well as putative neuropeptides from other families, in the control of or as diagnostic tools for vascular dementia...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Xue Yan Yihong Ma Limin Yan Simin Li Yuzhen Xu Source Type: research

Brain Mitochondria as a Therapeutic Target for Carnosic Acid
J Integr Neurosci. 2024 Mar 7;23(3):53. doi: 10.31083/j.jin2303053.ABSTRACTCarnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells. At least in part, those benefits are associated with the ability that CA modulates mitochondrial physiology. CA attenuated bioenergetics collapse and redox impairments in the mitochondria obtained from brain cells exposed to several toxicants in both in vitro and in vivo experimental models. CA is a potent inducer of the major modulator of the redox biology in animal...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Vittoria Infantino Ilaria Pappalardo Anna Santarsiero Swapnil Tripathi Gyanendra Singh Marcos Roberto de Oliveira Source Type: research

Association of Retinal Nerve Fiber Layer Thickness with Brain Microstructural Changes in Participants with White Matter Hyperintensities
CONCLUSIONS: We suggest neurodegeneration of peripapillary RNFL in older adults with WMH was associated with cerebral microstructural volume, impaired cerebral axonal damage, and cognitive performances. OCT metrics may provide evidence of neurodegeneration that may underpin WMH and cerebral microstructural changes in the brain.CLINICAL TRIAL REGISTRATION: This study was registered online at the China Clinical Trial Registration Center (registration number: ChiCTR-ROC-17011819).PMID:38538220 | DOI:10.31083/j.jin2303056 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Yucong Wu Jueyue Yan Lu Xu Chunfei Xu Meiqi Zhao Zhenxiang Zhan Yi Lu Xiaozhen Liu Yungang Cao Zhao Han Source Type: research

Neuromodulation of Cardiac Ischemic Pain: Role of the Autonomic Nervous System and Vasopressin
J Integr Neurosci. 2024 Mar 1;23(3):49. doi: 10.31083/j.jin2303049.ABSTRACTCardiac pain is an index of cardiac ischemia that helps the detection of cardiac hypoxia and adjustment of activity in the sufferer. Drivers and thresholds of cardiac pain markedly differ in different subjects and can oscillate in the same individual, showing a distinct circadian rhythmicity and clinical picture. In patients with syndrome X or silent ischemia, cardiac pain intensity may cause neurogenic stress that potentiates the cardiac work and intensifies the cardiac hypoxia and discomfort of the patient. The reasons for individual differences i...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Ewa Szczepanska-Sadowska Source Type: research

The Impact of PCSK9 Gene Polymorphisms on Ischemic Stroke: A Systematic Review and Meta-Analysis
CONCLUSIONS: This meta-analysis demonstrated that G allele variant of PCSK9 rs505151 and A allele variant of PCSK9 rs17111503 were associated with an increased risk of IS. Based on our findings, these SNPs could serve as potential targets for the diagnosis and treatment of IS. The integration of information on genetic polymorphism into IS risk prediction model may be beneficial in routine clinical practice.PMID:38538222 | DOI:10.31083/j.jin2303062 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jianhong Wang Shuang Li Yi Ren Guiquan Wang Weirong Li Source Type: research

Tanshinone IIA Regulates Synaptic Plasticity in Mg 2+ -Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway
CONCLUSIONS: TSIIA was effective in reducing harm to the synaptic plasticity of hippocampal neurons induced by persistent status epilepticus, with the possible mechanism being regulation of the phosphatidylinositol 3-kinase 56 (PI3K)/Akt signaling pathway.PMID:38538223 | DOI:10.31083/j.jin2303061 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Meile Ma Xi Hua Chen Jia Nan Xiao Li Zhang Liming Wei Haisheng Jiao Source Type: research

Optogenetic Inhibition of the Cortical Efferents to the Locus Ceruleus Region of Pontine Tegmentum Causes Cognitive Deficits
CONCLUSIONS: Our results reveal essential long-range regulatory circuits from the mPFC to LC and from LC to the limbic system that serves to optimize cognitive performance.PMID:38538224 | DOI:10.31083/j.jin2303060 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Eugene Dimitrov Source Type: research

Single Session Effects of Prolonged Continuous Theta Burst Stimulation Targeting Two Brain Regions on Pain Perception in Patients with Painful Diabetic Neuropathy: A Preliminary Study
CONCLUSIONS: In pDN patients with NP, our study results demonstrated significant improvement in scores on self-report measures of pain (SRMP) after a single session of pcTBS targeting the M1 and DLPFC brain regions. Future studies should consider utilizing multiple sessions of pcTBS to evaluate its long-term effects on pain perception, safety and tolerability in patients with chronic pain.CLINICAL TRIAL REGISTRATION: This study was registered on the ClinicalTrials.gov website (NCT04988321).PMID:38538225 | DOI:10.31083/j.jin2303054 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Bhushan Thakkar Carrie L Peterson Edmund O Acevedo Source Type: research

Translation from Preclinical Research to Clinical Trials: Brain-Gut Photobiomodulation Therapy for Alzheimer's Disease
This article outlines the translation from the preclinical to clinical stages of an innovative brain-gut PBM therapy in a mouse model of AD, a pilot clinical trial involving mild-to-moderate AD patients, and a continuing pivotal clinical trial with a similar patient population. In a mouse model of AD (Aβ25-35), daily application of brain-gut PBM therapy to both the head and the abdomen produced a neuroprotective effect against the neurotoxic effects of an Aβ25-35 peptide injection by normalizing all the modified behavioral and biochemical parameters. The pilot clinical trial to evaluate brain-gut PBM therapy demonstrated...
Source: Journal of Integrative Neuroscience - March 27, 2024 Category: Neuroscience Authors: Guillaume Blivet Fran çois J Roman Julien Delrieu Jacques Touchon Source Type: research