Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells

In conclusion, ICT increased intracellular ROS levels in liver cancer cells, which promoted the stabilization and activation of p53, inhibiting the expression of aerobic glycolysis-related genes and glycolysis, and ultimately leading to the suppression of liver cancer development.PMID:38431053 | DOI:10.1016/j.cbi.2024.110926

Source: Chemico-Biological Interactions - March 2, 2024 Category: Molecular Biology Authors: Xiangyang Zhou Di Wu Tian Mi Ruohan Li Tao Guo Wenjuan Li Source Type: research