Extraction, purification and anti-osteoporotic activity of a polysaccharide from Epimedium brevicornum Maxim. in vitro.
In conclusion, these results demonstrated that EBP pretreatment may be a potential therapeutic agent for patients with glucocorticoid-induced osteoporosis (GIO).
PMID: 31751710 [PubMed - as supplied by publisher] (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - November 17, 2019 Category: Biochemistry Authors: Zheng H, He B, Wu T, Cai J, Wei J Tags: Int J Biol Macromol Source Type: research
Down-regulation of microRNA-10a mediates the anti-tumor effect of icaritin in A549 cells via the PTEN/AKT and ERK pathway.
Abstract
Icaritin, a prenylflavonoid derivative from Epimedium Genus, has been reported to exhibit tumor inhibitory effects on many types of tumor cells. Numerous studies have demonstrated that microRNAs (miRs) involve in the biological process of carcinogenesis by controlling expression of their target mRNAs to facilitate tumor growth, invasion, angiogenesis, and immune evasion. miR-124 was reported to involve in the icaritin-induced mitochondrial apoptosis in human carcinoma cells. However, the roles of other miRs in the anti-tumor effects of icaritin and its underlying mechanisms still need to be elucid...
Source: General Physiology and Biophysics - October 31, 2019 Category: Physiology Authors: Lu X, Xue B, Zhang T, Zhou X, Zhang Y Tags: Gen Physiol Biophys Source Type: research
Pollinator effectiveness and importance between female and male mining bee (Andrena).
Abstract
Bees are often considered to be effective pollinators in both agricultural and natural ecosystems but could be ineffective pollinators in that they collect large quantities of pollen for food provision but deliver little to stigmas. Male bees do not collect pollen to feed larvae, and their pollination role has been underappreciated. Here we compare pollination effectiveness, visit frequency and pollen foraging behaviour between female and male individuals of a mining bee, Andrena emeishanica, visiting a nectariferous spring flower (Epimedium pubescens). Female bees were observed to forage for both...
Source: Biology Letters - October 30, 2019 Category: Biology Authors: Tang J, Quan QM, Chen JZ, Wu T, Huang SQ Tags: Biol Lett Source Type: research
Molecules, Vol. 24, Pages 3875: Icariin Promotes the Osteogenic Action of BMP2 by Activating the cAMP Signaling Pathway
In this study, we selected bone morphogenetic protein 2 (BMP2)-induced osteoblastic differentiation of multipotent mesenchymal progenitor C2C12 cells as a model of osteoblast differentiation. We investigated the effects of ICA on C2C12 cells osteogenic differentiation and the underlying molecular mechanisms. We found that ICA could enhance BMP2-mediated osteoblastic differentiation of C2C12 cells in a dose-dependent manner. Treatment with ICA activated the cAMP/PKA/CREB signaling axis in a time-dependent manner. Blocking cAMP signaling using the PKA selective inhibitor H89 significantly inhibited the stimulatory effect of ...
Source: Molecules - October 27, 2019 Category: Chemistry Authors: Meng Chen Yazhou Cui Hui Li Jing Luan Xiaoyan Zhou Jinxiang Han Tags: Article Source Type: research
Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in A β1-42-Injected Rats.
Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ1-42-Injected Rats.
Neurochem Res. 2019 Oct 15;:
Authors: Jiang X, Chen LL, Lan Z, Xiong F, Xu X, Yin YY, Li P, Wang P
Abstract
Macroautophagy, a sole pathway for dysfunctional organelles or aggregated proteins turnover, has been implicated in the early development of Alzheimer's disease (AD). Previous studies have found that reversal of autophagy dysfunction in APP transgenic mice ameliorates amyloid pathologies. Icariin (ICA), the main component from traditional Chinese herb Epimedium ...
Source: Neurochemical Research - October 14, 2019 Category: Neuroscience Authors: Jiang X, Chen LL, Lan Z, Xiong F, Xu X, Yin YY, Li P, Wang P Tags: Neurochem Res Source Type: research
