Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion.
Ö, Erbaş O Abstract Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment...
Source: Neurochemical Research - July 27, 2020 Category: Neuroscience Authors: Durankuş F, Şenkal E, Sünnetçi E, Albayrak Y, Beyazyüz M, Atasoy Ö, Erbaş O Tags: Neurochem Res Source Type: research

Estrogen Exerts Neuroprotective Effects in Vascular Dementia Rats by Suppressing Autophagy and Activating the Wnt/ β-Catenin Signaling Pathway.
Estrogen Exerts Neuroprotective Effects in Vascular Dementia Rats by Suppressing Autophagy and Activating the Wnt/β-Catenin Signaling Pathway. Neurochem Res. 2020 Jul 27;: Authors: Yang Y, Zhao L, Li N, Dai C, Yin N, Chu Z, Duan X, Niu X, Yan P, Lv P Abstract Vascular dementia (VD) is a clinical syndrome of acquired cognitive dysfunction caused by various cerebrovascular factors. Estrogen is a steroid hormone involved in promoting neuronal survival and in regulating many signaling pathways. However, the mechanism by which it confers neuroprotective effects in VD remains unclear. Here, we aimed to...
Source: Neurochemical Research - July 27, 2020 Category: Neuroscience Authors: Yang Y, Zhao L, Li N, Dai C, Yin N, Chu Z, Duan X, Niu X, Yan P, Lv P Tags: Neurochem Res Source Type: research

miR-29c-3p Increases Cell Viability and Suppresses Apoptosis by Regulating the TNFAIP1/NF- κB Signaling Pathway via TNFAIP1 in Aβ-Treated Neuroblastoma Cells.
In conclusion, our findings confirmed that miR-29c-3p attenuated Aβ-induced neurotoxicity through regulation of NF-κB signaling pathway by directly targeting TNFAIP1, providing the potential value for the treatment of AD patients. PMID: 32712875 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 25, 2020 Category: Neuroscience Authors: Liu Z, Zhang H, Sun L, Zhu K, Lang W Tags: Neurochem Res Source Type: research

Pristine C60 Fullerene Nanoparticles Ameliorate Hyperglycemia-Induced Disturbances via Modulation of Apoptosis and Autophagy Flux.
Abstract Diabetes mellitus is a prevalent metabolic disorder associated with multiple complications including neuropathy, memory loss and cognitive decline. Despite a long history of studies on diabetic complications, there are no effective therapeutic strategies for neuroprotection in diabetes. Hyperglycemia-induced imbalance in programmed cell death could initiate a decline in neural tissue cells viability. Various nanomaterials can induce either cell death or cell survival dependent on the type and surface features. Pristine C60 fullerene is a nontoxic nanomaterial, which exhibits antioxidant and cytoprotective...
Source: Neurochemical Research - July 25, 2020 Category: Neuroscience Authors: Demir E, Nedzvetsky VS, Ağca CA, Kirici M Tags: Neurochem Res Source Type: research

GPR50 Distribution in the Mouse Cortex and Hippocampus.
In this study, we examined the distribution of GPR50 in adult male mice by immunofluorescence. Our results showed that GPR50 was localized in the CA1-3 pyramidal cells and the granule cells of the dentate gyrus. GPR50 was also expressed in excitatory and inhibitory neurons. As inhibitory neurons also contain many types, we found that GPR50 was localized in some interneurons in which it was co-expressed with the calcium-binding proteins calbindin, calretinin, and parvalbumin. Besides, similar results were seen in the cortex. The widespread expression of GPR50 in the hippocampus and cortex suggests that GPR50 may be associat...
Source: Neurochemical Research - July 21, 2020 Category: Neuroscience Authors: Li Q, Zhang Y, Ge BY, Li N, Sun HL, Ntim M, Sun YP, Wu XF, Yang JY, Li S Tags: Neurochem Res Source Type: research

Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines.
In conclusion, diosgenin showed anti-tumor effects in glioblastoma cells by induction of differentiation and apoptosis and inhibition of migration, invasion, and angiogenesis. PMID: 32683533 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 18, 2020 Category: Neuroscience Authors: Khathayer F, Ray SK Tags: Neurochem Res Source Type: research

Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.
In conclusion, BACE1-AS aggravated isoflurane-induced neurotoxicity to AD via sponging miR-214-3p. PMID: 32681443 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 17, 2020 Category: Neuroscience Authors: He W, Chi S, Jin X, Lu J, Zheng W, Yan J, Zhang D Tags: Neurochem Res Source Type: research

Novel Role of HAX-1 in Neurons Protection After Spinal Cord Injury Involvement of IRE-1.
In this study, we found that the expression and distribution of HAX-1 in neurons increased 1 day after SCI. PC12 cells overexpressing HAX-1 showed decreased apoptosis and PC12 cells are more likely to undergo apoptosis after down-regulating HAX-1, which was confirmed via TUNEL experiments. We found GRP94 showed the same trend as HAX-1 in expression and interacted with HAX-1 and IRE-1 in both spinal cord tissue and PC12 cells, and this interaction seems to be enhanced after SCI. When the expression of HAX-1 was up-regulated, GRP94 also increased, but IRE-1 did not change at all. Further studies showed that overexpressi...
Source: Neurochemical Research - July 17, 2020 Category: Neuroscience Authors: Chen J, Yang S, Wu C, Cui Z, Wan Y, Xu G, Bao G, Zhang J, Chen C, Song D Tags: Neurochem Res Source Type: research

Neuroprotective Effect Of Peptide Fractions from Chia (Salvia hispanica) on H2O2-Induced Oxidative Stress-Mediated Neuronal Damage on N1E-115 Cell Line.
os MR Abstract Neurodegenerative diseases (ND) affect around a billion people worldwide. Oxidative stress plays a critical role in the activation of neuronal death mechanisms, implicated in the ND etiology. In the present research, the neuroprotective effect of the S. hispanica protein derivatives is evaluated, on neuronal cells N1E-115, after the damage induction with H2O2. From the protein-rich fraction of S. hispanica, three peptide fractions were obtained (3-5, 1-3 y
Source: Neurochemical Research - July 16, 2020 Category: Neuroscience Authors: Martínez Leo EE, Segura Campos MR Tags: Neurochem Res Source Type: research

Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A.
Abstract Fibromyalgia is a refractory syndrome characterized by chronic wayward pain and complex co-morbid psychological trepidation. The current treatments have a limited role and proper clinical benefits are far from satisfactory. Naturally occurring coumarins such as osthole are known to have analgesic and anti-inflammatory activities. Therefore, the current investigation was designed to explore the potential of natural coumarin esculetin (2.5, 5, and 10 mg/kg) in mitigating reserpine-induced fibromyalgia in Swiss albino mice. Esculetin is a 6,7 dihydroxy-coumarin obtained from various plant sources such a...
Source: Neurochemical Research - July 16, 2020 Category: Neuroscience Authors: Singh L, Kaur A, Garg S, Singh AP, Bhatti R Tags: Neurochem Res Source Type: research

Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway.
Abstract Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. So this study explored the role of NOX2 in TBI models treated with DHA, aiming to complete the mechanism of DHA. TBI rat models were constructed with or without DHA treatment, and H2O2-induced hippocampal neurons were pretreated with DHA alone or in combination with Nrf2 inhibitor brusatol. The neurological function, cognitive ability, and cerebral edema degree of rats were assessed. The apoptosis rat...
Source: Neurochemical Research - July 16, 2020 Category: Neuroscience Authors: Zhu W, Cui G, Li T, Chen H, Zhu J, Ding Y, Zhao L Tags: Neurochem Res Source Type: research

Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
Abstract Inflammation secondary to tissue injuries serves as a double-edged sword that determines the prognosis of tissue repair. As one of the most important enzymes controlling the inflammation process by producing leukotrienes, 5-lipoxygenase (5-LOX, also called 5-LO) has been one of the therapeutic targets in regulating inflammation for a long time. Although a large number of 5-LOX inhibitors have been explored, only a few of them can be applied clinically. Surprisingly, phosphorylation of 5-LOX reveals great significance in regulating the subcellular localization of 5-LOX, which has proven to be an important ...
Source: Neurochemical Research - July 15, 2020 Category: Neuroscience Authors: He Z, Tao D, Xiong J, Lou F, Zhang J, Chen J, Dai W, Sun J, Wang Y Tags: Neurochem Res Source Type: research

Long-Term Alternating Fasting Increases Interleukin-13 in the Gerbil Hippocampus, But Does Not Protect BBB and Pyramidal Neurons From Ischemia-Reperfusion Injury.
This study examined whether IF increased anti-inflammatory cytokines and protected neurons from ischemia-reperfusion injury in the gerbil hippocampus. Gerbils were subjected to 1-day alternating fasting as IF for 1, 2, or 3 months and assigned to sham or 5 min of transient ischemia. We examined the changes in anti-inflammatory cytokines (IL-4 and IL-13), neurons and IgG by immunohistochemistry or immunofluorescence staining in the cornu ammonis 1 (CA1) region of the hippocampus before and after ischemia. IF increased IL-13 immunoreactivity in the CA1 region before ischemia, but did not affect IL-4 immunoreactivit...
Source: Neurochemical Research - July 15, 2020 Category: Neuroscience Authors: Lee TK, Park Y, Kim B, Lee JC, Shin MC, Ohk TG, Park CW, Cho JH, Park JH, Lee CH, Won MH, Ahn JH Tags: Neurochem Res Source Type: research

Guanosine Neuroprotective Action in Hippocampal Slices Subjected to Oxygen and Glucose Deprivation Restores ATP Levels, Lactate Release and Glutamate Uptake Impairment: Involvement of Nitric Oxide.
This study was designed to investigate the involvement of nitric oxide (NO) in the mechanisms related to the protective role of guanosine in rat hippocampal slices subjected to OGD followed by reoxygenation (OGD/R). Guanosine (100 μM) and the pan-NOS inhibitor, L-NAME (1 mM) afforded protection to hippocampal slices subjected to OGD/R. The presence of NO donors, DETA-NO (800 μM) or SNP (5 μM) increased reactive species production, and abolished the protective effect of guanosine or L-NAME against OGD/R. Guanosine or L-NAME treatment prevented the impaired ATP production, lactate release, and gl...
Source: Neurochemical Research - July 14, 2020 Category: Neuroscience Authors: Thomaz DT, Andreguetti RR, Binder LB, Scheffer DDL, Corrêa AW, Silva FRMB, Tasca CI Tags: Neurochem Res Source Type: research

The Combination of Cholecystokinin and Stress Amplifies an Inhibition of Appetite, Gastric Emptying, and an Increase in c-Fos Expression in Neurons of the Hypothalamus and the Medulla Oblongata.
In this study, we aimed to clarify the influence of stress on the action of cholecystokinin (CCK) on appetite and gastric emptying. Using rats, stress was simulated by giving restraint stress or intraperitoneal injection of the stress-related peptide hormone urocortin 1 (UCN1). The effects of CCK and restraint stress, alone or in combination, on food intake and gastric motility were examined, and c-Fos expression in the neurons of appetite control network in the central nervous system was assessed by immunohistochemical staining. CCK inhibited food intake and gastric emptying in a dose-dependent manner. Food intake for 1&n...
Source: Neurochemical Research - July 14, 2020 Category: Neuroscience Authors: Yamaguchi N, Hosomi E, Hori Y, Ro S, Maezawa K, Ochiai M, Nagoshi S, Takayama K, Yakabi K Tags: Neurochem Res Source Type: research

Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
Abstract Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by impaired motor symptoms induced by the degeneration of dopaminergic neurons of the substantia nigra pars compacta (SNc). Many factors are speculated to operate in the mechanism of PD, including oxidative stress, mitochondrial dysfunction, abnormal protein handling, and PD induced apoptosis. Besides, researchers have recently shown that inflammatory secretions may engage neighboring cells such as astrocytes, which then induce autocrine and paracrine responses that amplify the inflammation, leading to neurodegeneration. In the...
Source: Neurochemical Research - July 9, 2020 Category: Neuroscience Authors: Li W, Goshima Y, Ohshima T Tags: Neurochem Res Source Type: research

Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats.
Abstract A large amount of document has revealed that the orexin system in the reward circuity, including the nucleus accumbens (NAc), contributes to the modification of drug reinforcement. It has proven that the orexin receptors (OXRs) are expressed on dopamine terminals in the NAc; therefore, it can modulate reward-related behaviors. In the present study, the conditioned place preference (CPP) paradigm was used to evaluate the role of OXRs in the NAc in the acquisition and expression of methamphetamine (METH)-induced CPP. Based on previous studies, animals received METH (1 mg/kg; sc) on a 5-day schedule to ...
Source: Neurochemical Research - July 8, 2020 Category: Neuroscience Authors: Khosrowabadi E, Karimi-Haghighi S, Jamali S, Haghparast A Tags: Neurochem Res Source Type: research

Correction to: L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism.
CD Abstract The original version of this published article, the bottom right hand panels of Figs. 3-6 were labelled as "Isotopomers formed from [1-13C]D-glucose". This is incorrect and should read "Isotopomers formed from [1,2-13C]acetate". This has been corrected by publishing this correction article. PMID: 32638216 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 7, 2020 Category: Neuroscience Authors: Das A, Fröhlich D, Achanta LB, Rowlands BD, Housley GD, Klugmann M, Rae CD Tags: Neurochem Res Source Type: research

The Runx1/Notch1 Signaling Pathway Participates in M1/M2 Microglia Polarization in a Mouse Model of Temporal Lobe Epilepsy and in BV-2 Cells.
In conclusion, Runx1 may play a critical role in the M2-to-M1 microglial phenotype shift via the Notch1 signaling pathway during epileptogenesis in a TLE mouse model and in BV-2 cells. PMID: 32632543 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 6, 2020 Category: Neuroscience Authors: Deng XL, Feng L, Wang ZX, Zhao YE, Zhan Q, Wu XM, Xiao B, Shu Y Tags: Neurochem Res Source Type: research

β-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway.
In conclusion, our findings revealed that β-asarone could reduce oxidative stress via activating Nrf2/HO-1 pathway in PC12 cells, highlighting the potential therapeutic role of β-asarone in neurodegenerative diseases. PMID: 32623664 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - July 4, 2020 Category: Neuroscience Authors: Hei X, Xie M, Xu J, Li J, Liu T Tags: Neurochem Res Source Type: research

Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection.
Abstract Role of autophagy in Japanese encephalitis viral (JEV) infection is not well known. In the present study, we reported the role of autophagy flux in microglia activation, neurobehavioral function and neuronal death using a mouse model of JEV. Markers for autophagy (LC3-II/I, SQSTM1/P62, phos-Akt, phos-AMPK), and neuronal death (cleaved caspase 12, H2Ax, polyubiquitin) were investigated by western blot at 1, 3 and 7 days post inoculation. Cathepsin D was measured in cerebral cotex of JEV infected mice spectrophotometrically. Microglia activation and pro-inflammatory cytokines (IL1β, TNF-α, I...
Source: Neurochemical Research - July 1, 2020 Category: Neuroscience Authors: Kumar A, Kalita J, Sinha RA, Singh G, B A, Shukla M, Tiwari S, Dhole TN, Misra UK Tags: Neurochem Res Source Type: research

Acute Valproate Exposure Induces Sex-Specific Changes in Steroid Hormone Metabolism in the Cerebral Cortex of Juvenile Mice.
In this study, VPA-induced acute metabolic alterations were investigated using liquid chromatography-tandem mass spectrometry in prepubertal mice brain. In VPA-treated (400 mg/kg in saline solution, intraperitoneal) mice, cortisol levels were increased (female: P 
Source: Neurochemical Research - June 29, 2020 Category: Neuroscience Authors: Cho SH, Chai JH, Chang SY, Kim SA Tags: Neurochem Res Source Type: research

Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway.
Abstract Postoperative cognitive dysfunction (POCD) is a common complication induced by anesthesia or surgery, which affects the concentration, cognition and memory of patients. Sevoflurane, a clinical anesthetic, could stimulate neuro-inflammation and lead to POCD. Recent studies found that specificity protein 1 (SP1) participates in the development of neurological diseases. Our study aims to elucidate the role of SP1 in sevoflurane-induced POCD pathogenesis. We anesthetized Sprague-Dawley rats and treated the primary hippocampal neurons with sevoflurane to construct the in vivo and in vitro POCD models. Besides,...
Source: Neurochemical Research - June 27, 2020 Category: Neuroscience Authors: Lv G, Li C, Wang W, Li N, Wang K Tags: Neurochem Res Source Type: research

Studies on the Neuromodulatory Effects of Ginkgo biloba on Alterations in Lipid Composition and Membrane Integrity of Rat Brain Following Aluminium Neurotoxicity.
Abstract Brain contains the highest lipid content involved in various structural and physiological activities such as structural development, neurogenesis, synaptogenesis, signal transduction and myelin sheath formation. Lipids bilayer is essential to maintain the structural integrity for the physiological functions of protein. Impairments in lipid metabolism and its composition can lead to the progression of various brain ailments such as neurodegenerative and neuropsychiatric disorders. Aluminium (Al), the potent neurotoxin has been linked to Alzheimer's disease (AD) like pathology. Al can bind to biomembrane an...
Source: Neurochemical Research - June 27, 2020 Category: Neuroscience Authors: Verma S, Ranawat P, Nehru B Tags: Neurochem Res Source Type: research

LncRNA MALAT1 Promotes OGD-Induced Apoptosis of Brain Microvascular Endothelial Cells by Sponging miR-126 to Repress PI3K/Akt Signaling Pathway.
This study aimed to investigate the role of MALAT1 in IS in vitro model and the related molecular mechanisms. The expressions of MALAT1 and miR-126 were detected by qPCR. The in vitro IS model was established by treating BMECs with oxygen-glucose deprivation (OGD). Cell viability and cell apoptosis were assessed by MTT assay and flow cytometry, respectively. Luciferase assay was conducted to examine the interplay between MALAT1 and miR-126. Western blotting was used to determine the protein levels of apoptosis-associated proteins (e.g. caspase 3, Bax and Bcl-2) and PI3K/Akt pathway-related proteins (e.g. PI3K, Akt, p-PI3K,...
Source: Neurochemical Research - June 26, 2020 Category: Neuroscience Authors: Zhang L, Yang H, Li WJ, Liu YH Tags: Neurochem Res Source Type: research

Retraction Note to: MicroRNA-322 Cluster Promotes Tau Phosphorylation via Targeting Brain-Derived Neurotrophic Factor.
Abstract The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the Editors found that the additional data were not adequate to support the conclusion of the article and that P-values for the additional data were based on improper statistical analyses. With more appropriate statistical analysis, the reported effects for miR-322 and BDNF were not statistically...
Source: Neurochemical Research - June 25, 2020 Category: Neuroscience Authors: Zhang J, Liu Z, Pei Y, Yang W, Xie C, Long S Tags: Neurochem Res Source Type: research

Brain Microvascular Endothelial Cell Derived Exosomes Potently Ameliorate Cognitive Dysfunction by Enhancing the Clearance of A β Through Up-Regulation of P-gp in Mouse Model of AD.
Brain Microvascular Endothelial Cell Derived Exosomes Potently Ameliorate Cognitive Dysfunction by Enhancing the Clearance of Aβ Through Up-Regulation of P-gp in Mouse Model of AD. Neurochem Res. 2020 Jun 24;: Authors: Pan J, He R, Huo Q, Shi Y, Zhao L Abstract Accumulation of amyloid-β (Aβ) peptides in the brain is regarded as a major contributor to the pathogenesis and progression of Alzheimer's disease (AD). P-glycoprotein (P-gp) as a member of ABC transporter family situated in blood brain barrier (BBB) plays a role on cleaning of Aβ via its efflux transport effect in the treat...
Source: Neurochemical Research - June 24, 2020 Category: Neuroscience Authors: Pan J, He R, Huo Q, Shi Y, Zhao L Tags: Neurochem Res Source Type: research

A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1's Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells.
A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1's Expression and H2O2-Induced Cytotoxicity in SH-SY5Y Cells. Neurochem Res. 2020 Jun 18;: Authors: Cheng C, Zheng N, Sun D, Fang W, Zheng L, Song W, Huang J Abstract The abnormally accumulated amyloid-β (Aβ) and oxidative stress contribute to the initiation and progression of Alzheimer's disease (AD). β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for the production of Aβ. Furthermore, Aβ was reported to increase o...
Source: Neurochemical Research - June 18, 2020 Category: Neuroscience Authors: Cheng C, Zheng N, Sun D, Fang W, Zheng L, Song W, Huang J Tags: Neurochem Res Source Type: research

Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.
Abstract Polyphenols from Toona sinensis seeds (PTSS) have demonstrated anti-inflammatory effects in various diseases, while the anti-neuroinflammatory effects still remain to be investigated. We aimed to investigate the effects of PTSS on Parkinson's disease and underlying mechanisms using a rat model. We employed 6-hydroxydopamine (6-OHDA) to male Sprague Dawley (SD) rats and PC12 cells to construct the in vivo and vitro models of PD and dopaminergic (DA) neuron injury, respectively. Cell viability was detected by cell counting kit-8 (CCK-8) assay and protein levels of inflammatory mediators and some p38 MAPK pa...
Source: Neurochemical Research - June 17, 2020 Category: Neuroscience Authors: Zhuang W, Cai M, Li W, Chen C, Wang Y, Lv E, Fu W Tags: Neurochem Res Source Type: research

Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model.
This study sought to evaluate how butyrate, one of SCFAs, affect the pathology in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treated mouse model of PD. Sodium butyrate (NaB; 165 mg/kg/day i.g., 7 days) was administrated from the day after the last MPTP injection. Interestingly, NaB significantly aggravated MPTP-induced motor dysfunction (P 
Source: Neurochemical Research - June 16, 2020 Category: Neuroscience Authors: Qiao CM, Sun MF, Jia XB, Li Y, Zhang BP, Zhao LP, Shi Y, Zhou ZL, Zhu YL, Cui C, Shen YQ Tags: Neurochem Res Source Type: research

Transplantation of Mesenchymal Stromal Cells Expressing the Human Preproenkephalin Gene Can Relieve Pain in a Rat Model of Neuropathic Pain.
In conclusion, our study shows that the TAS improves BMSC transgenic therapy for neuropathic pain treatment. PMID: 32529390 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - June 11, 2020 Category: Neuroscience Authors: Yang J, Zhang L, Xie P, Pan M, Ma G Tags: Neurochem Res Source Type: research

Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington's Disease.
i L, Klivényi P, Zádori D Abstract The potential role of Sirt1 and Sirt2 subtypes of Sirtuins (class III NAD+-dependent deacetylases) in the pathogenesis of Huntington's disease (HD) has been extensively studied yielding some controversial results. However, data regarding the involvement of Sirt3 and their variants in HD are considerably limited. The aim of this study was to assess the expression pattern of Sirt1 and three Sirt3 mRNA isoforms (Sirt3-M1/2/3) in the striatum, cortex and cerebellum in respect of the effect of gender, age and the presence of the transgene using the N171-82Q transgenic mo...
Source: Neurochemical Research - June 10, 2020 Category: Neuroscience Authors: Salamon A, Maszlag-Török R, Veres G, Boros FA, Vágvölgyi-Sümegi E, Somogyi A, Vécsei L, Klivényi P, Zádori D Tags: Neurochem Res Source Type: research

Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice.
In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression. PMID: 32500408 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - June 5, 2020 Category: Neuroscience Authors: Luduvico KP, Spohr L, Soares MSP, Teixeira FC, de Farias AS, Bona NP, Pedra NS, de Oliveira Campello Felix A, Spanevello RM, Stefanello FM Tags: Neurochem Res Source Type: research

A Critical Role for ISGylation, Ubiquitination and, SUMOylation in Brain Damage: Implications for Neuroprotection.
Abstract Post-translational modification (PTMs) of proteins by ubiquitin and ubiquitin-like modifiers such as interferon-stimulated gene 15 (ISG15) and small ubiquitin-related modifier (SUMO) play a critical role in the regulation of brain pathophysiology. Protein ISGylation is a covalent attachment of ISG15 to its target proteins, which is a unique PTM among other ubiquitin-like modifiers. Although, ISG15 shares sequence homology to ubiquitin, yet the functional significance of protein ISGylation is distinct from ubiquitination and SUMOylation. Further, ISG15 highly conserved among vertebrate species, unlike the ...
Source: Neurochemical Research - June 4, 2020 Category: Neuroscience Authors: Nakka VP, Mohammed AQ Tags: Neurochem Res Source Type: research

Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats.
Abstract Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn2+ 1 and 5 mg/kg, every 10 days for 150 days (15 injections). Animal body weight and behavioral activities were recorded. At the end of experiments, the brain and liver were collected for morphological and molecular analysis. Chronic Mn exposure did not affect animal body weight gain, but the high dose of Mn treat...
Source: Neurochemical Research - June 2, 2020 Category: Neuroscience Authors: Fan XM, Luo Y, Cao YM, Xiong TW, Song S, Liu J, Fan QY Tags: Neurochem Res Source Type: research

Neuroprotective Role of Quercetin on Rotenone-Induced Toxicity in SH-SY5Y Cell Line Through Modulation of Apoptotic and Autophagic Pathways.
Abstract The detrimental impact on the food chain due to the overuse of rotenone is partly responsible for alpha-synuclein (α-syn) mediated neurotoxicity. It is hypothesized that rotenone overdose leads to cytosolic proteopathy resulting in modulation of apoptosis and autophagic pathways. The aim of our study is to explore the neuroprotective role of quercetin, a beneficial polyphenol against rotenone-induced neurotoxicity in dopaminergic human SH-SY5Y cell lines. In our study we demonstrated the correlation of rotenone-induced neurotoxicity through elevation of intracellular reactive oxygen species (ROS) an...
Source: Neurochemical Research - June 1, 2020 Category: Neuroscience Authors: Pakrashi S, Chakraborty J, Bandyopadhyay J Tags: Neurochem Res Source Type: research

Mulberry Fruit Extract Alleviates Cognitive Impairment by Promoting the Clearance of Amyloid- β and Inhibiting Neuroinflammation in Alzheimer's Disease Mice.
Mulberry Fruit Extract Alleviates Cognitive Impairment by Promoting the Clearance of Amyloid-β and Inhibiting Neuroinflammation in Alzheimer's Disease Mice. Neurochem Res. 2020 Jun 01;: Authors: Liu D, Du D Abstract Alzheimer's disease (AD) is a common neurodegenerative disease, always clinically manifesting with memory loss and other cognitive abilities serious enough to interfere with daily life. Over the past decade, the extensive accumulation of Aβ plaques and the related neuroinflammation such as the activation of glial cells have been frequently demonstrated to contribute to the pathog...
Source: Neurochemical Research - June 1, 2020 Category: Neuroscience Authors: Liu D, Du D Tags: Neurochem Res Source Type: research

MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats.
Abstract Increasing evidence has revealed that neuroinflammation plays a pivotal role in axonal injures. Nucleotide oligomerization domain (NOD)-like receptor protein (NLRP3) inflammasome is reported to be widely involved with the pathology of central nervous system disorders. But the role of NLRP3 in diffuse axonal injury (DAI) are rarely reported. The purpose of this study was to investigate the expression of NLRP3 after diffuse axonal injury and the role of NLRP3 in axonal injures. The lateral head rotation device was used to establish DAI model of rats. Immunohistochemical staining for β-amyloid precursor...
Source: Neurochemical Research - May 30, 2020 Category: Neuroscience Authors: Zhao J, Guo X, Wang B, Yang Z, Huang T, Guo D, Zhang M, Song J Tags: Neurochem Res Source Type: research

Promising Polyphenols in Parkinson's Disease Therapeutics.
Abstract Parkinson's disease (PD) is a slow progressive, second most common neurodegenerative disease characterized by the loss of dopaminergic neurons from the nigrostriatal pathway. In spite of extensive research the therapeutics options of disease are limited which only offer symptomatic relief and could not prevent the disease progression. Therefore researchers are looking for the probable synthetic or natural compounds for the PD therapeutics. Due to mandatory chronic consumption of anti PD drug to the PD patients, the natural compounds are getting attention recently. Numerous studies have indicated the neuro...
Source: Neurochemical Research - May 27, 2020 Category: Neuroscience Authors: Singh A, Tripathi P, Yadawa AK, Singh S Tags: Neurochem Res Source Type: research

The Involvement of Mitochondrial Biogenesis in Selenium Reduced Hyperglycemia-Aggravated Cerebral Ischemia Injury.
Abstract Selenium has been shown to possess antioxidant and neuroprotective effects by modulating mitochondrial function and activating mitochondrial biogenesis. Our previous study has also suggested that selenium protected neurons against glutamate toxicity and hyperglycemia-induced damage by regulating mitochondrial fission and fusion. However, it is still not known whether the mitochondrial biogenesis is involved in selenium alleviating hyperglycemia-aggravated cerebral ischemia reperfusion (I/R) injury. The object of this study is to define whether selenium protects neurons against hyperglycemia-aggravated cer...
Source: Neurochemical Research - May 23, 2020 Category: Neuroscience Authors: Yang L, Ma YM, Shen XL, Fan YC, Zhang JZ, Li PA, Jing L Tags: Neurochem Res Source Type: research

β-Caryophyllene Liposomes Attenuate Neurovascular Unit Damage After Subarachnoid Hemorrhage in Rats.
This study was conducted to prepare β-caryophyllene loaded liposomes (BCP-LP) and investigated their effects on neurovascular unit (NVU) damage after subarachnoid hemorrhage (SAH) in rats. A blood injection into the pre-chiasmatic cistern was used to achieve SAH. BCP-LP were prepared, characterized and administrated to rats with SAH. The prepared BCP-LP were spherical with a size distribution of approximately 189.3 nm and Zeta potential of - 13.9 mV. Neurological scoring, the balance beam test, cerebral blood flow monitoring, brain edema and biochemical analyses were applied to evaluate the effects of B...
Source: Neurochemical Research - May 22, 2020 Category: Neuroscience Authors: Wang F, Teng Z, Liu D, Wang Y, Lou J, Dong Z Tags: Neurochem Res Source Type: research

Neuroprotective Effects of Lacosamide and Memantine on Hyperoxic Brain Injury in Rats.
This study aimed to evaluate neuroprotective effects of lacosamide and memantine treatment in a hyperoxia-induced brain injury model in immature rats. This study was performed in the Animal Experiments Laboratory of Dokuz Eylul University Faculty of Medicine. Neonatal Wistar strain rat pups were exposed to hyperoxia (80% oxygen + 20% nitrogen) for five days postnatally. They were divided into five groups; hyperoxia + lacosamide, hyperoxia + memantine, hyperoxia + lacosamide and memantine, hyperoxia + saline, control groups. After termination of the exper...
Source: Neurochemical Research - May 22, 2020 Category: Neuroscience Authors: Polat İ, Cilaker Mıcılı S, Çalışır M, Bayram E, Yiş U, Ayanoğlu M, Okur D, Edem P, Paketçi C, Tuğyan K, Yılmaz O, Hız Kurul S Tags: Neurochem Res Source Type: research

Antidepressant-Like Activities of Hispidol and Decursin in Mice and Analysis of Neurotransmitter Monoamines.
Abstract The antidepressant activities of hispidol and decursin (both potent monoamine oxidase A (MAO-A) inhibitors) were evaluated using the forced swimming test (FST) and the tail suspension test (TST) in mice, and thereafter, levels of neurotransmitter monoamines and metabolites in brain tissues were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Hispidol (15 mg/kg) caused less or comparable immobility than fluoxetine (15 mg/kg; the positive control) in immobility time, as determined by FST (9.6 vs 32.0 s) and TST (53.1 vs 48.7 s), respectively, and its effects were dose-dependent and si...
Source: Neurochemical Research - May 21, 2020 Category: Neuroscience Authors: Oh JM, Lee HS, Baek SC, Lee JP, Jeong GS, Paik MJ, Kim H Tags: Neurochem Res Source Type: research

L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism.
CD Abstract L-Ornithine-L-aspartate (LOLA), a crystalline salt, is used primarily in the management of hepatic encephalopathy. The degree to which it might penetrate the brain, and the effects it might have on metabolism in brain are poorly understood. Here, to investigate the effects of LOLA on brain energy metabolism we incubated brain cortical tissue slices from guinea pig (Cavea porcellus) with the constituent amino acids of LOLA, L-ornithine or L-aspartate, as well as LOLA, in the presence of [1-13C]D-glucose and [1,2-13C]acetate; these labelled substrates are useful indicators of brain metabolic activity. L...
Source: Neurochemical Research - May 18, 2020 Category: Neuroscience Authors: Das A, Fröhlich D, Achanta LB, Rowlands BD, Housley GD, Klugmann M, Rae CD Tags: Neurochem Res Source Type: research

HAP1 Modulates Epileptic Seizures by Regulating GABAAR Function in Patients with Temporal Lobe Epilepsy and in the PTZ-Induced Epileptic Model.
This study provides evidence that hippocampal HAP1 is linked to GABAARs in evoking seizures and suggests that this mechanism is involved in epileptic seizures in the brain, representing a potential therapeutic target for epilepsy. PMID: 32419121 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - May 17, 2020 Category: Neuroscience Authors: Li R, Wu B, He M, Zhang P, Zhang Q, Deng J, Yuan J, Chen Y Tags: Neurochem Res Source Type: research

Special Issue in Honour of Michael B Robinson.
PMID: 32418081 [PubMed - as supplied by publisher] (Source: Neurochemical Research)
Source: Neurochemical Research - May 16, 2020 Category: Neuroscience Authors: Beart PM Tags: Neurochem Res Source Type: research

Capsaicin and Its Analogues Impede Nocifensive Response of Caenorhabditis elegans to Noxious Heat.
Abstract Capsaicin is the most abundant pungent molecule identified in red chili peppers, and it is widely used for food flavoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other related vanilloid compounds are secondary plant metabolites. Capsaicin is a selective agonist of the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1). After exposition to vanilloid solution, Caenorhabditis elegans wild type (N2) and mutants were placed on petri dishes divided in quadrants for heat stimulation. Thermal avoidance in...
Source: Neurochemical Research - May 16, 2020 Category: Neuroscience Authors: Nkambeu B, Salem JB, Beaudry F Tags: Neurochem Res Source Type: research

Matrix Metalloproteinase-9 Overexpression Regulates Hippocampal Synaptic Plasticity and Decreases Alcohol Consumption and Preference in Mice.
Abstract Brain matrix metalloproteinases (MMPs) have been recently implicated in alcohol addiction; however, the molecular mechanisms remain poorly understood. Matrix metalloproteinase-9 (MMP-9), an extrasynaptic protease, is the best described MMP that is thought to regulate addictive behavior. In the present study, the effect of MMP-9 overexpression on hippocampal neuron plasticity and alcoholic behavior was assessed in spontaneous alcohol drinking mice. Two-bottle choice model showed that the overexpression of MMP-9 in the hippocampus developed by adeno-associated virus (AAV) could decrease alcohol consumption ...
Source: Neurochemical Research - May 15, 2020 Category: Neuroscience Authors: Yin LT, Xie XY, Xue LY, Yang XR, Jia J, Zhang Y, Zhang C Tags: Neurochem Res Source Type: research

Early Intervention of Gastrodin Improved Motor Learning in Diabetic Rats Through Ameliorating Vascular Dysfunction.
Abstract The mechanism of cognitive dysfunction in diabetes is still unclear. Recently, studies have shown that the cerebellum is involved in cognition. Furthermore, diabetes-induced cerebellar alterations is related to vascular changes. Therefore, we aimed to explore the roles of vascular function in diabetes-induced cerebellar damage and motor learning deficits. Type 1 diabetes was induced by a single injection of streptozotocin in Sprague-Dawley rats. Motor learning was assessed by beam walk test and beam balance test. The pathological changes of the cerebellum were assessed by Hematoxylin and eosin staining an...
Source: Neurochemical Research - May 15, 2020 Category: Neuroscience Authors: Zhang F, Deng CK, Huang YJ, Miao YH, Wang YY, Zhang Y, Qian ZY, Zhang WQ, Zhou RD, Lei B, Shen X, Wu XY, Cui G, Song JL, Mu ZH, Zou YY Tags: Neurochem Res Source Type: research

Safflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in A β1-42-induced AD Model Rats.
In this study, we aimed to clarify whether the effects of SY and HSYA on the learning and memory abilities of Aβ1-42-induced AD model rats are related to the enhancement of synaptic structural plasticity in brain tissues and the amelioration of disorder of glutamate circulation. We used rats injected with Aβ1-42 into the bilateral hippocampus as a model of AD. After treatment with SY and HSYA, the learning and memory abilities of the Aβ1-42-induced AD model rats were enhanced, Aβ deposition in the AD model rats was decreased, structural damage to dendritic spines and the loss of synaptic-associated prot...
Source: Neurochemical Research - May 14, 2020 Category: Neuroscience Authors: Hou J, Wang C, Zhang M, Ren M, Yang G, Qu Z, Hu Y Tags: Neurochem Res Source Type: research