Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in A β1-42-Injected Rats.

Icariin Ameliorates Amyloid Pathologies by Maintaining Homeostasis of Autophagic Systems in Aβ1-42-Injected Rats. Neurochem Res. 2019 Oct 15;: Authors: Jiang X, Chen LL, Lan Z, Xiong F, Xu X, Yin YY, Li P, Wang P Abstract Macroautophagy, a sole pathway for dysfunctional organelles or aggregated proteins turnover, has been implicated in the early development of Alzheimer's disease (AD). Previous studies have found that reversal of autophagy dysfunction in APP transgenic mice ameliorates amyloid pathologies. Icariin (ICA), the main component from traditional Chinese herb Epimedium brevicornu Maxim., can reduce accumulations of amyloid-β (Aβ) peptide in vivo and in vitro, but the mechanism remains unclear. Here, we explored the effects of ICA on autophagy-lysosomal pathway in intracerebroventricular (icv) injection of human Aβ1-42 peptide rats. We demonstrated that feeding the rats with ICA (30 mg/kg, 60 mg/kg and 90 mg/kg rat, per os) for 4 weeks rescued the Aβ1-42-induced spatial memory impairments, reduced endogenous rat Aβ42 tested by ELISA and decreased Aβ accumulation using 6E10 antibody. Furthermore, Aβ1-42 induced strong autophagy response, however ICA decreased the levels of microtubule-associated protein 1 light chain 3 (LC3) II/LC3I, Beclin1, Cathepsin D (Cat D) and brain lysosomal Cathepsin D activity. We also observed that ICA enhanced the phosphorylation of protein kinase B ...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
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Source: JAMA Neurology - Category: Neurology Source Type: research
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Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Nature Reviews Neurology, Published online: 11 November 2019; doi:10.1038/s41582-019-0289-7A high-salt diet leads to the development of hallmark Alzheimer disease (AD) pathology and cognitive impairment in mice, according to new research published in Nature. The study reveals previously unknown molecular mechanisms that could have therapeutic implications.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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