Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors
As known, inhibition of phosphodiesterase 5 (PDE5) has the therapeutic effect on male erectile dysfunction (ED), and the processed folium of Epimedium sagittatum Maxim. (PFES) characterized by 8-isopentenyl flavo... (Source: Chinese Medicine)
Source: Chinese Medicine - December 31, 2022 Category: Complementary Medicine Authors: Juntao Li, Yue Wu, Xinxin Yu, Xinyu Zheng, Jiechen Xian, Senjie Li, Wanyin Shi, Yun Tang, Zhe-Sheng Chen, Guixia Liu, Shen Yao, Jian Xu and Xiangwei Zheng Tags: Research Source Type: research
Calcium phosphate cement with icariin-loaded gelatin microspheres as a local drug delivery system for bone regeneration
Icariin (ICA), a main active ingredient of Herba Epimedium, could promote bone formation, inhibit bone resorption and alleviate inflammatory responses. The aim of this study was to investigate the effect of IC... (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - December 22, 2022 Category: Biomedical Engineering Authors: Ning Liu, Shuo Huang, Fang Guo, Shafei Zhai, Danyang Wang, Fang Li and Changkui Liu Tags: Research Source Type: research
Mechanism of Epimedium intervention in heart failure based on network pharmacology and molecular docking technology
This study reveals the multi-component, multi-target and multi-pathway mechanism of action of Epimedium in regulating mental failure, and provides a basis for the clinical development and utilization of Epimedium to intervene in HF. (Source: Medicine)
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress
Eur J Pharmacol. 2022 Nov 10:175378. doi: 10.1016/j.ejphar.2022.175378. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is one of the most serious global public health concerns. However, there are currently no effective drugs for treatment of this disease. Icariin (ICA), a small-molecule natural product extracted from Epimedium brevicornu Maxim, offers various pharmacological activities. In the present work, we wondered whether ICA can attenuate NAFLD in db/db mice treated with ICA for 8 weeks and how ICA exert an influence on NAFLD. In db/db mice, ICA treatment had a robust effect on inhibition of ...
Source: European Journal of Pharmacology - November 13, 2022 Category: Drugs & Pharmacology Authors: Peng Yu Zhen Qian Hongmei Yang Tianyang Xu Yulin Dai Laihui Song Jinling Liang Yuying Shi Zhiguo Zhang Lijing Li Source Type: research
Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress
Eur J Pharmacol. 2022 Nov 10:175378. doi: 10.1016/j.ejphar.2022.175378. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is one of the most serious global public health concerns. However, there are currently no effective drugs for treatment of this disease. Icariin (ICA), a small-molecule natural product extracted from Epimedium brevicornu Maxim, offers various pharmacological activities. In the present work, we wondered whether ICA can attenuate NAFLD in db/db mice treated with ICA for 8 weeks and how ICA exert an influence on NAFLD. In db/db mice, ICA treatment had a robust effect on inhibition of ...
Source: European Journal of Pharmacology - November 13, 2022 Category: Drugs & Pharmacology Authors: Peng Yu Zhen Qian Hongmei Yang Tianyang Xu Yulin Dai Laihui Song Jinling Liang Yuying Shi Zhiguo Zhang Lijing Li Source Type: research
Icariin as an emerging candidate drug for anticancer treatment: Current status and perspective
Biomed Pharmacother. 2022 Nov 9;157:113991. doi: 10.1016/j.biopha.2022.113991. Online ahead of print.ABSTRACTIcariin (ICA) is a kind of natural flavonoid compound monomer, which is derived from the extract of dried stems and leaves of Epimedium. Modern pharmacological studies have found that ICA has broad bioactive function in affecting the biological processes of a variety of cancers, including breast cancer, colorectal cancer, hepatocellular carcinoma, esophageal cancer and other cancers, which indicates that ICA has promising application value in the treatment of cancer patients in the future. Nevertheless, the targets ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2022 Category: Drugs & Pharmacology Authors: Yufang Liu Han Yang Jie Xiong Juanjuan Zhao Mengmeng Guo Jing Chen Xu Zhao Chao Chen Zhixu He Ya Zhou Lin Xu Source Type: research
Icariin as an emerging candidate drug for anticancer treatment: Current status and perspective
Biomed Pharmacother. 2022 Nov 9;157:113991. doi: 10.1016/j.biopha.2022.113991. Online ahead of print.ABSTRACTIcariin (ICA) is a kind of natural flavonoid compound monomer, which is derived from the extract of dried stems and leaves of Epimedium. Modern pharmacological studies have found that ICA has broad bioactive function in affecting the biological processes of a variety of cancers, including breast cancer, colorectal cancer, hepatocellular carcinoma, esophageal cancer and other cancers, which indicates that ICA has promising application value in the treatment of cancer patients in the future. Nevertheless, the targets ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2022 Category: Drugs & Pharmacology Authors: Yufang Liu Han Yang Jie Xiong Juanjuan Zhao Mengmeng Guo Jing Chen Xu Zhao Chao Chen Zhixu He Ya Zhou Lin Xu Source Type: research
Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways
In this study, human umbilical vein endothelial cells (HUVECs) were stimulated with Icariside II in the presence or absence of multiple inhibitors (1 µM), including LY294002 (PI3K-inhibitor), MK-2206 (AKT-inhibitor), Bisindolylmaleimide X (AMPK-inhibitor), H-89 (CaMKII-inhibitor), KN-62 (PKA-inhibitor), Dorsomorphin (PKC-inhibitor). The proliferation of HUVECs was assessed using cell counting kit-8 (CCK-8). The release of nitric oxide (NO) within HUVECs was detected via fluorescence probe (DAF-FM). Western blot was used to examine the effect of Icariside II on the expression of eNOS, phosphorylation of eNOS, and common si...
Source: Atherosclerosis - October 31, 2022 Category: Cardiology Authors: Wenpeng Song Yiming Yuan Xiaohui Tan Yangyang Gu Jianyu Zeng Weidong Song Zhongcheng Xin Dong Fang Ruili Guan Source Type: research
Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways
In this study, human umbilical vein endothelial cells (HUVECs) were stimulated with Icariside II in the presence or absence of multiple inhibitors (1 µM), including LY294002 (PI3K-inhibitor), MK-2206 (AKT-inhibitor), Bisindolylmaleimide X (AMPK-inhibitor), H-89 (CaMKII-inhibitor), KN-62 (PKA-inhibitor), Dorsomorphin (PKC-inhibitor). The proliferation of HUVECs was assessed using cell counting kit-8 (CCK-8). The release of nitric oxide (NO) within HUVECs was detected via fluorescence probe (DAF-FM). Western blot was used to examine the effect of Icariside II on the expression of eNOS, phosphorylation of eNOS, and common si...
Source: Atherosclerosis - October 31, 2022 Category: Cardiology Authors: Wenpeng Song Yiming Yuan Xiaohui Tan Yangyang Gu Jianyu Zeng Weidong Song Zhongcheng Xin Dong Fang Ruili Guan Source Type: research
Immunostimulatory activity and structure-activity relationship of epimedin B from Epimedium brevicornu Maxim.
Epimedii Folium (EF, Epimedium brevicornu Maxim.), a traditional botanical drug, is famous for treating bone fractures, joint diseases, and several chronic illnesses. However, some studies indicated that EF could induce idiosyncratic drug-induced liver injury (IDILI) in the clinic. The NLRP3 inflammasome plays a crucial role in the pathogenesis of various human diseases, including IDILI. In the present study, we showed that epimedin B could specifically facilitate nigericin- or ATP-induced NLRP3 inflammasome activation under synergistic induction of mitochondrial reactive oxygen species. Moreover, epimedin B resulted in ac...
Source: Frontiers in Pharmacology - October 31, 2022 Category: Drugs & Pharmacology Source Type: research
Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer
Epimedium brevicornum Maxim. (Epimedii Folium) is a traditional medicine widely utilized in China for sexual dysfunction and osteoporosis treatment. Recently, studies have reported that Epimedium flavonoid icariin displayed hair growth and melanogenic ability by targeting tyrosinase activity. Nevertheless, icariin hydrolysate icariside II and icaritin cause depigmentation due to their tyrosinase inhibition. These pigment functional discrepancies from Epimedium constituents arouse our great interest. Then, this study focused on the pigmentation effects of Epimedii Folium extract (EFE) on melanin synthesis and melanosome bio...
Source: Frontiers in Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Source Type: research
A New β-Ionone from Epimedium sagittatum
A newβ-ionone, episagittatone (1), and eight known compounds were isolated from the stems ofEpimedium sagittatum (Berberidaceae). The structure of1 was determined by interpretation of the spectroscopic data. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - September 23, 2022 Category: Chemistry Source Type: research
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels
CONCLUSIONS: BYR affects endogenous cholesterol synthesis and testosterone synthesis to prevent and treat EILST levels in rats. It can improve the body's sports ability.PMID:36063102 | DOI:10.1080/13880209.2022.2110126 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 5, 2022 Category: Drugs & Pharmacology Authors: Yirong Wang Xiyang Peng Zhihong Zhou Changfa Tang Wenfeng Liu Source Type: research
Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation
Chem Biol Interact. 2022 Aug 23:110125. doi: 10.1016/j.cbi.2022.110125. Online ahead of print.ABSTRACTEpimedokoreanin B (EKB) is a prenylated flavonoid isolated from Epimedium koreanum. In this article, we described the anti-cancerous effects of EKB and its underlying mechanism in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells. EKB treatment inhibited cell proliferation and migration accompanied by cytoplasmic vacuolation in both cell lines. The cell death induced by EKB lacked the features of apoptosis like chromatin condensation, phosphatidyl serine exposure and caspase cleavage. The vacuoles stimulated...
Source: Chemico-Biological Interactions - August 26, 2022 Category: Molecular Biology Authors: Hao Zheng Qingying Liu Shuqi Wang Xiaoqing Liu Mengjiao Ma Tao Shen Xiaoning Wang Dongmei Ren Source Type: research
Bioactive natural compounds as potential medications for osteogenic effects in a molecular docking approach
Bone defect repair and fracture healing are critical challenges in clinical treatments. Bioactive natural compounds are potential resources for medications for osteogenic effects. We have identified icariin, the effective ingredient of Epimedium pubescens, to promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs) and repair bone defects. To explore more natural compounds with the potential modality for bone repair, in the present study, we employed an icariin-induced gene expression pattern as an osteogenic model and screened the Connectivity Map database for small molecules with gene expression signatur...
Source: Frontiers in Pharmacology - August 24, 2022 Category: Drugs & Pharmacology Source Type: research
