Synthesis and Antioxidant Activity Evaluation of Trolox Derivatives
To find potent antioxidants, 16 novel Trolox derivatives were designed and synthesized via a reduction and esterification reaction. The chemical structures were characterized by NMR and MS. Trolox derivatives were employed to explore the potential structure –antioxidant activity relationships using three different assays. The results revealed that some of the synthesized compounds exhibited stronger antioxidant activities than L-ascorbic acid and Trolox, which suggests such compounds warrant further study. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

A New Dimeric Lignan from Machilus philippinensis
A new dimeric lignan, machiphilippin (1), was isolated from the stems of Machilus philippinensis Merr. (Lauraceae). The structure of the new dimeric lignan was elucidated by chemical and physical evidence. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Hydrolysis of Lappaconitine in Acidic Solution. Preparation of N -Deacetyllappaconitine
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

A Novel Ethyl 3( R )-Acetamido-3-(4-Hydroxyphenyl)Propanoate from the Marine Isolate of the Fungus Penicillium thomii KMM 4680
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

A New Sesquiterpene Lactone from Eupatorium chinense and its Anti-TNBC Activity
A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with the nucleophilic residues of the relevant active site and produce a variety of bioactivities. Eupachiilide A demonstrated potent cytotoxicity against two TNBC cell lines. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Chemical Constituents of the Stems of Orostachys malacophyllus
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Compositions of Fatty Acids and Sterols from Angelica sylvestris
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Chemical Composition and Antimicrobial Activity of Scutellaria araxensis Essential Oil from Iran
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Flavonoids from the Aerial Part of Alhagi persarum of the Flora of Uzbekistan and Their Biological Activity
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Hypolipidemic Lactone Derivatives from Highland Barley Monascus
A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione (1), together with nine known lactone derivatives (2 –10), was isolated from highland barley Monascus for the first time. Compounds1 –10 were studied by spectroscopic methods and comparison with references and evaluated for their hypolipidemic activities by measuring the triglyceride content in HepG2 cells with simvastatin as positive control. Among them, compounds1 and7 (10 μM) exhibited moderate hypolipidemic activities. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

ANTI-INFLAMMATORY CONSTITUENTS OF Dichapetalum longipetalum
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 28, 2020 Category: Chemistry Source Type: research

Rearrangement of Epoxide Derivatives Semisynthesized from β -Himachalene using Lewis and Bronsted Acids Catalysis
The acid-catalyzed rearrangement of epoxides3a,4a,6a, and7a derived from β-himachalene, the major constituent of Cedrus atlantica essential oil, has been studied using various Lewis and Bronsted acids. Several new enantiomerically pure ketones were obtained in good yields and high selectivities. All products obtained were fully characterized by1H and13C NMR, and the mechanistic explanations for their formation were proposed. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 27, 2020 Category: Chemistry Source Type: research

Chemical Constituents of Mycelium from Endophytic Fungus HJ-3 Strain of Tamarix chinensis
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 27, 2020 Category: Chemistry Source Type: research

Two New Oleanane Triterpenoids from Syzygium samarangense
Two new oleanane triterpenoids, sysamarins F (1) and G (2), along with one known analogue (3), were isolated from the leaves of Syzygium samarangense. Their structures were elucidated by means of extensive spectroscopic techniques, including interpretation of 1D and 2D NMR spectra and comparison with the values reported in the literature. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 27, 2020 Category: Chemistry Source Type: research

Synthesis and Analgesic Activity Assessment of Furanolabdanoid Conjugates with Glucuronic Acid
Phlomisoic acid reacted with methyl-1-deoxy-2,3,4-tri-O-acetyl-1-bromo-α-D-glucopyranuronate to form the 18-O-β-D-(glucuronopyranoside)-6 ′-O-methyl ester of 15,16-epoxylabda-8(9),13,14-triene. Reductive amination of methyl 16-formyl-15,16-epoxylabda-8(9),13,14-trienoate or thisβ-D-glucuronopyranoside of 16-formyl-15,16-epoxylabda-8(9),13,14-triene by propargylamine in the presence of NaBH4 gave the corresponding 16-propargylaminomethyl-15,16-epoxylabda-8(9),13,14-trienes. Copper-catalyzed azide-alkyne cycloaddition of the new terpenoid alkynes and the propargylamide of phlomisoic acid with methyl 1-d...
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Indole Alkaloids from Vinca erecta , Structure and Stereochemistry
Stereochemical and structural aspects of series of indoline, α-methyleneindoline, indolenine, indole, and 2-oxoindoline alkaloids. The stereochemistry of the molecules is analyzed. The descriptors of the chiral centers of indole alkaloids fromVinca erecta are determined. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

α -GLUCOSIDASE INHIBITOR ISOLATED FROM Potentilla anserina
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Neuroprotective Flavonoids from the Aerial Parts of Gynura cusimbua
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

A New Apocarotenoid of Cinnamomum burmannii
A new apocarotenoid, burmannic acid (1), was isolated from the roots ofCinnamomum burmannii (Nees& T. Nees) Blume (Lauraceae). The structure of the new apocarotenoid was elucidated by chemical and physical evidence. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Chemical Constituents of the Artificial Fruit Body of Antrodia cinnamomea
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Xanthones from Swertia nervosa and their Inhibitory Effects on Nitric Oxide Production
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

A New Phenolic Glycoside from the Seeds of Moringa oleifera
A new phenolic glycoside derivative, moringapyranosyl (1), along with five known phenolic glycoside derivatives (2 –6), was isolated from the seeds of Moringa oleifera. Their structures were identified by spectroscopic analyses and by comparison of their spectral data with those reported in the literature. The inhibitory activities of all compounds against α-glucosidase were evaluated. Compounds1 –6 showed significant inhibitory activities against α-glucosidase. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Chemical Composition, Antibacterial and Antioxidant Activities of the Essential Oil of Psychotria serpens
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

STEROL COMPOUNDS AND THEIR ANTI-COMPLEMENTARY ACTIVITIES OF Cordia dichotoma
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Secondary Metabolites with Plant Growth Regulator Activity Produced by an Endophytic Fungus Purpureocillium sp. from Solanum rostratum
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Alkaloids and Terpenoids from Trigonostemon lutescens and their Potential Antiproliferative Activity
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Phenolic Constituents of Syzygium austroyunnanense
Twelve phenolic compounds, including one new phloroglucinol derivative, were isolated from the leaves of Syzygium austroyunnanense. Their structures were elucidated based on the spectroscopic data and by comparison with the literature. All of compounds were firstly isolated from this species. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Identification of Aszonalenin Derivatives as α -Glucosidase Inhibitors from Neosartorya fischeri NRRL 181
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Alkaloids from the Plant Delphinium naviculare var. lasiocarpum
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

CHEMICAL CONSTITUENTS OF Agaricus gennadii
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Correction to: Chemical Constituents of Zanthoxylum bungeanum
To the article “Chemical Constituents ofZanthoxylum bungeanum, ” by Bing-Qing Zhu, Jing-Fan Yang, Tong-Tong Song, Xiao-Fei Li, Tao Guo, Li-Li Wang, Ya Wang, and Jun Chang, Vol. 56, No. 1, pp. 164–165, January, 2020. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Index of Natural Objects
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 26, 2020 Category: Chemistry Source Type: research

Bioactive Alkaloids from Whole Plants of Thalictrum cultratum
Two new tricyclic alkaloids (1 and2), together with three known (3–5) alkaloids, were isolated from the whole plants ofThalictrum cultratum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds1–5 were tested for their anti-rotavirus activity. The results revealed that compounds1–5 exhibited potent anti-rotavirus activity with therapeutic index (TI) values in the range 10.7 –17.7. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments
Series of drimane and homodrimane sesquiterpenoids with oxadiazole and thiadiazole fragments were synthesized. Their antifungal and antibacterial activities were studied. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

A New Austalide from Penicillium sp. SO01
Five austalide meroterpenoids, including a new one named 13-deoxyaustalide Q acid methyl ester, were isolated from the ethyl acetate extract of the fungusPenicillium sp. SO01. The structure of the new compound was determined on the basis of IR, UV, HR-ESI-MS NMR spectra and CD data. The cytotoxicities of compound1 against three human tumor cell lines were also tested, with IC50 values of 27.66 μM (SW-1990 cell line), 28.77 μM (Hep3B cell line), and 39.93 μM (HepG2 cell line). (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Fatty Acid Composition of the Oil from the Fruit of Three Species of Palm Trees Found in the Amazon: Astrocaryum gynacanthum, Geonoma deversa, and Iriartella setigera
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Induced Production of Tremulane Sesquiterpenoids in Bjerkandera adusta by Chemical Epigenetic Modification
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Secondary Metabolites of Elaeagnus grandifolia
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Secondary Metabolites and their Biological Activities from the Sponge Derived Fungus Aspergillus versicolor
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Cytotoxic Hydroperoxycochliodinol Derivative from Endophytic Chaetomium sp. Isolated from Salvia officinalis
The endophytic fungusChaetomium sp. was separated from the medicinal plantSalvia officinalis growing in Egypt and cultivated on solid rice medium. Chemical investigation of the EtOAc extract yielded a new hydroperoxycochliodinol derivative (1) in addition to several known compounds, which included cochliodinol (2), isocochliodinol (3), chaetomin (4), and two simple indole derivatives (5,6). The structure of the new compound was determined by comprehensive NMR studies including DEPT, COSY, HMQC, HMBC, and HR-MS. All compounds were tested for their cytotoxic activity against L5178Y cells. Compounds1,2, and4 showed cytotoxic ...
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Synthesis of New Exocyclic Allenes with Diterpene Fragments
New stable allenes with exocyclic cumulene groups were synthesized fromN-maleopimarimide-substituted amino acids using phenyl(triphenylphosphoranylidene)succinimide, 2-fluorophenyl(triphenylphosphoranylidene)-succinimide, and benzyl(triphenylphosphoranylidene)succinimide. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Compounds from Claoxylon indicum
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

A New 27-Norcucurbitane Triterpenoid from the Fruits of Momordica charantia var. abbreviata
A new 27-norcucurbitane triterpenoid, 5β,19-epoxy-3β-hydroxy-19(R)-methoxy-27-norcucurbita-6,23(E)-dien-25-one (1), was isolated from the fruits ofMomordica charantia var.abbreviata. Its structure was elucidated by spectroscopic analyses including 1D and 2D NMR (1H,13C, COSY, HMQC, HMBC, and NOESY) and comparison with the data of known analogues. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Shikonin and its Esters from Buglossoides arvensis and Other Species of the Family Boraginaceae
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Iridoids from Veronica crista-galli from the Flora of Azerbaijan
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 25, 2020 Category: Chemistry Source Type: research

Synthesis and First-Time Assessment of o -Eugenol Derivatives against Mycobacterium tuberculosis
This study provides important information on the rational design of new lead anti-TB drugs based on o-eugenol derivatives . (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 24, 2020 Category: Chemistry Source Type: research

New Flavonoids from Artemisia frigida
New flavonoids were isolated from the aerial part of Artemisia frigida Willd. (Asteraceae). Their structures were elucidated using UV, IR, and NMR spectroscopy and mass spectrometry as chrysoeriol-7-O-(2 ′′-Oacetyl)-β-D-glucopyranoside (2′′-O-acetylthermopsoside), jaceosidin-4′ -O-β-D-glucopyranoside (isojaceoside), and 13 known flavonoids. The influence of the isolated compounds on α-glucosidase activity and triglyceride accumulation in 3T3-L1 preadipocytes was studied. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 24, 2020 Category: Chemistry Source Type: research

New Compounds from Flowers of Phlojodicarpus sibiricus
Chromatographic separation of the MeOH extract from flowers of Phlojodicarpus sibiricus (Fisch.) Koso.-Pol. (Apiaceae) isolated 27 compounds including three new glycosides, the structures of which were established by UV, IR, and NMR spectroscopy and mass spectrometry as (R)-peucedanol -7-O-(6 ″-O-β-D-apiofuranosyl)-β-D-glucopyranoside-3′-O-β-D-glucopyranoside (phlojosibiriside I,1), diosmetin-7-O-(6 ″-O-β-D-apiofuranosyl)-β-D-glucopyranoside (phlojosibiriside II,2), and diosmetin-7-O-(2 ″-O-acetyl-6″-O-β-D- apiofuranosyl)-β-D-glucopyranoside (phlojosibiriside...
Source: Chemistry of Natural Compounds - July 24, 2020 Category: Chemistry Source Type: research

4-Methyl-7-Amino/Amido Coumarin Derivatives as Potential Antimicrobials and Antioxidants
An array of previously synthesized 4-methyl-7-amino and amido coumarins4a –u has been screened for their antimicrobial and antioxidant properties. Some of the compounds exhibited promising antibacterial and antifungal activities (MIC ranging from 4 –64 μg/mL) when compared to the respective standards. Compound4u showed comparable antibacterial activity with the standard, ciprofloxacin, whereas compounds4u and4t displayed promising antifungal activity when compared to the standard, fluconazole. The in silico docking studies against gyrase enzyme revealed the fact that4u possessed hydrogen bonding and signific...
Source: Chemistry of Natural Compounds - July 24, 2020 Category: Chemistry Source Type: research

A New Pyrone from Cinnamomum macrostemon
Cinnamopyrone (1), a new cinnamomum 2-pyrone, has been isolated from the roots of Cinnamomum macrostemon (Lauraceae). The structure was characterized and identified by spectral analysis. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 24, 2020 Category: Chemistry Source Type: research