Anthraquinone and Naphthoquinone Derivatives from the Pericarps of Juglans sigillata
Four new anthraquinones (1 –4), along with four known ones (5 –8) and five known naphthoquinones (9 –13), were isolated from the green pericarps of Juglans sigillata. The structures of the new compounds were elucidated as 1,3-diethoxycarbonyl-8-hydroxy-9,10-anthraquinone (1), 1,3-diethoxycarbonyl-5-hydroxy-9,10-anthraquinone (2), 1-ethoxycarbonyl-8-hydroxy-9,10-anthraquinone (3), and 1-ethoxycarbonyl-5-hydroxy-9,10-anthraquinone (4), based on extensive spectroscopic methods including HR-ESI-MS and 1D and 2D NMR spectra. Compounds1 –12 were evaluated for their in vitro cytotoxicities against MCF-7 an...
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Recent Progress in the Synthesis of 4-Arylcoumarins
Current approaches to the synthesis of 4-arylcoumarins (neoflavones) are reviewed. This is an important group of O-containing natural flavonoids that are widely used not only to prepare natural and synthetic neoflavone analogs but also to design compound libraries based on 4-arylcoumarins for biological activity studies. The use of new transition-metal catalysts and unconventional activation methods for cyclization of the coumarin system, arylation of activated coumarins, and direct arylation of unactivated coumarins are discussed. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Imidazolium-Sulfobetaine Based on Betulin with Proliferative Activity for HEK293 and T -Lymphocyte Cells
A betulin derivative with an (imidazolium)butane-1-sulfonate fragment was synthesized and promoted proliferation in vitro of HEK293 and human T-lymphocyte cells, suggesting that this compound had immunostimulant properties. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Novel Method for O -Acetylation of Cholesterol, Allobetulin, and Betulin
Primary and secondary triterpene alcohols were acetylated for the first time using tetraacetylglycoluril (TAGU). Cholesterol, allobetulin, and betulin acetates were obtained in high yields. The acetylation usedp-TsOH or TFA in refluxing CHCl3. TFA was found to be an effective acetylation catalyst. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Lipoxygenase and α -Glucosidase Inhibitory Constituents of Phlomis stewartii
Two new sphingolipids, stewartins A: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyoctadec-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-D-glucopyranoside,1] and B: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyeicos-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-glucopyranoside,2], along with nine known compounds (3 –11) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant ofPhlomis stewartii. Compounds1,2,4, and6 showed inhibitory potential against the enzyme lipoxygenase (LOX) in a concentration-dependent manner with IC50 values ranging between 42.2 ± 0.2 to 55.7 ± 0.8 &mu...
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Cytochalasins from Xylaria sp., an Endophytic Fungus from Turnera ulmifolia
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 19, 2019 Category: Chemistry Source Type: research

Synthesis and Properties of 2-Carboxyethyland 2-Carboxypropylchromones
Reaction features of polyhydroxydeoxybenzoins and their heteroatomic analogs with succinic and glutaric anhydrides were studied and shown to be useful for synthesizing 3-(3-pyrazolyl)butyric acids and 4,11-dioxo-8,10,11,12-tetrahydro-4H,9H-pyrano[2,3-a]xanthene derivatives with a butyric acid moiety. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Two New Isoflavones from the Flowers of Rosa damascena and Their Biological Activities
Two new isoflavones, 6-hydroxy-7-(3-hydroxypropyl)-4 ′-methoxyisoflavone (1) and 6,4 ′-dihydroxy-7-(3-hydroxypropyl)-isoflavone (2), were isolated from the flowers ofRosa damascena. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1 and2 were evaluated for their anti-methicillin-resistantStaphylococcus aureus (anti-MRSA) activity. The results revealed that compounds1 and2 showed weak inhibition with IZD of 11.6 ± 1.2 and 11.2 ± 1.0 mm, respectively. Compounds1 and2 were also tested for their antioxidant activity and showed good activ...
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

A New Furan-Coumarin from Clausena lansium
A new furan-coumarin, claulancoumarin (1), together with a known coumarin, clausenalansimin A (2), were isolated from the branches and leaves of Clausena lansium. Their structures were elucidated by spectroscopic analysis, including high-resolution mass spectroscopy, and IR, UV, and 1D and 2D NMR techniques. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Indole Alkaloids from the Aerial Parts of Kopsia fruticosa
A phytochemical investigation of the ethanol extract ofKopsia fruticosa resulted in the isolation of two new indole alkaloids, 3-oxo-11,12-dimethoxy-N1-decarbomethoxy-14,15-didehydrochanofruticosinate (1) and 11,12-dimethoxydanuphylline (2). Their structures were established on the basis of extensive chromatographic properties and chemical and physicochemical methods. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Two New Diphenyl Ether Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii
Two new diphenyl ethers, 1-[2-methoxy-4-(3-methoxy-5-methylphenoxy)-6-methylphenyl]-ethanone (1) and 1-[4-(3-(hydroxymethyl)-5-methoxyphenoxy)-2-methoxy-6-methylphenyl]-ethanone (2), together five known diphenyl ether derivatives (3 –7), were isolated from the fermentation products of an endophytic fungusPhomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1 and2 were evaluated for their anti-methicillin-resistantStaphylococcus aureus (anti-MRSA) activity. Compounds1 and2 showed good inhibition with IZD of 13.8 ± 1.5 mm and 14.6 &...
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Ozonolytic Transformations of ( S )-( –)-Limonene and Abietic Acid in the Presence of Pyridine
Controlled ozonolysis of (S)-( –)-limonene in the presence of Py gave 4-methyl-3-(3-oxobutyl)pent-4-enal or 4-methyl-3-(3-oxobutyl)pent-4-enoic acid depending on the solvent (CH2Cl2 or MeOH). Exhaustive ozonolysis produced 3-acetyl-6-oxoheptanoic acid. Ozonolysis of abietic acid in CH2Cl2 in the presence of Py formed stable epoxytrioxolaneabietic acid; in MeOH –Py, the epoxyketoaldehyde corresponding to cleavage of the C13–C14 bond. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Nannochloropsis oculata
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Isolation and Spectral Studies of a New Lactone Triterpenoid from Lantana camara
A new lactone triterpenoid lantanolide along with four known triterpenoids were isolated from the ether fraction of above-ground parts of Lantana camara L. The chemical structure of the new compound was determined to be 3-oxo-12 α,22β,25-trihydroxy-18β-olean-28,13β-olide (1), based on spectroscopic data including UV, IR, EI-MS, HR-EI-MS, and 1D and 2D NMR. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Index of Natural Objects
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Correction to: Synthesis of Aminoalkylated Aziridines from (+)-3-Carene
The name of the fourth author should read C. Pannecouque. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Acridocarpus orientalis and Their Chemotaxonomic Significance
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Synthesis of Natural and Biologically Active Quinoxaline Analogs
Reactions of quinoxalines and quinoxalin-2-ones withC-nucleophiles under acid-catalysis conditions gave products from nucleophilic substitution of hydrogen. Substitution of F atoms in the aromatic core of quinoxalines was studied. Antibacterial and fungistatic activity of the synthesized compounds was studied. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Chemical Constituents of the Stems of Gynura procumbens
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Constituent Composition of the Hexane Fraction of the Extract of Haplophyllum perforatum and Its Insecticidal Activity
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Chemical Composition of Tubers of Bletilla striata
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

A New Cucurbitacin Glucoside from Luffa graveolense
A new cucurbitacin glucoside has been isolated from an ethanolic extract of Luffa graveolense, along with four known cucurbitacins. Its structure has been assigned as 20-O- β-D-glucopyranosyl cucurbitacin B (2) by spectroscopic analysis. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Antifungal and Antibacterial Activities of Azaphilones from the Gorgonian-Derived Penicillium sclerotiorum Fungus
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Synthesis and Properties of 8-Substituted 1-(2-Oxopropyl)Theobromine Derivatives
A method for preparing previously unreported and potentially biologically active 1-(2-oxopropyl)theobromine derivatives was developed. Their physicochemical properties and antibacterial and antifungal activities were studied. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Triterpenic Acids from Sorbaria sorbifolia
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Synthesis of the Natural Product Iotrochamide B
Iotrochamide B is the first cinnamoyl amino acid reported from the marine spongeIotrochota sp. The total synthesis of the marine indole alkaloid iotrochamide B was achieved by condensation of 6-bromo-L-tryptophan (3) and (Z)-2-methoxy-3-phenylacrylic acid (6). The key step was the synthesis of 6-bromo-L-tryptophan ((S)-3) from racemicN-acetyltryptophan by optical resolution using (S)-( –)-1-phenylethylamine. This work provides an efficient method for future synthesis of iotrochamide B derivatives. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Liparis viridiflora
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

New Lignan from the Flowers of Forsythia koreana
A new lignan (1) was isolated from the flowers of Forsythia koreana along with one known lignan, 4,4 ′-di-O-β-D-glucosylpinoresinol (2). The molecular structures were determined using spectral methods. These compounds were isolated from F. koreana flowers for the first time. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

One-Pot Synthesis of 2nd Ruthenium Grubbs Catalyst for Preparation of One Stapled Peptide
2nd Grubbs catalyst was prepared using a new strategy for efficient preparation of a stapled peptide. The reaction was short and avoided the effect of oxygen and moisture. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

Nonpolar Constituents of Inula grandis Roots. Cytotoxic Activity of Igalan
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 17, 2019 Category: Chemistry Source Type: research

A New Polyphenolic Glycoside from Scutellaria barbata
A new polyphenolic glycoside1, together with three known compounds (2 –4), was isolated from Scutellaria barbata by repeated column chromatography. Its structure was identified as 1-O- β-D-glucopyranosyl-(2R)-3-(4-hydroxy-3,5-dimethoxyphenyl)-propanediol (1) by spectroscopic data (1H NMR,13C NMR, HSQC, HMBC, and ORD) and chemical method. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Antimicrobial and Cytotoxic Activities of Secondary Metabolites from the Soft Coral Derived Fungus Aspergillus sp.
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Extracellular Extract of Haematococcus pluvialis
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

A New Flavonoid Glycoside from Schizonepeta annua
A new flavonoid glycoside 1 was isolated from Schizonepeta annua (Pall.) Schischk. by column chromatography. Its structure was determined to be acacetin 7-O- α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→6)]-β-D-glucopyranoside (1) by spectroscopic data (1H NMR,13C NMR,1H −1H COSY, HSQC, and HMBC) and chemical methods. In addition, the α-glucosidase inhibitory activity of compound 1 was evaluated. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Bark of Phellodendron chinense
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Flavone Glucosides from the Aerial Part of Scutellaria comosa
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

A New Phenolic Compound with Anti-Inflammation Activity From Caulophyllum robustum
A new phenolic compound, named (E)-2,4-bis(p-hydroxyphenyl)-2-butenol (1), together with three known compounds were isolated from the radix and rhizome of Caulophyllum robustum Maxim. Their structures were elucidated on the basis of spectral data. The anti-inflammation characteristics of the new compound and the three known compounds were tested. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Chemical Constituents of Bangia fuscopurpurea
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Chemical Composition and Anticholinesterase Activity of Lagochilus inebrians
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Synergistic Catalysis of Glycosyltransferase and Sucrose Synthase to Produce Isoquercitrin Through Glycosylation of Quercetin
Isoquercitrin exhibits a number of biological properties and has a higher water solubility than quercetin. In this work, an Arabidopsis glycosyltransferase with high activity on quercetin (AtUGT78D2) was coupled with an efficient quercetin-tolerant Glycine max sucrose synthase (GmSUS) to synthesize isoquercitrin by regenerating UDP-glucose from UDP. The important factors for optimal synergistic catalysis were determined. Through the use of a fed-batch operation, the final titer of isoquercitrin increased to 3830 mg/L with a corresponding molar conversion of 94.3% and a maximum number of UDP-glucose regeneration cycles (RCm...
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Phenolic Compounds from Thunia alba and Their Inhibitory Effects on Nitric Oxide Production
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Constituents of Cosmos bipinnatus
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

A New Quassinoid from Brucea javanica and its Antiplasmodial and Cytotoxic Activities
Brujavanol E (1), a new quassinoid derivative, along with four known quassinoids (2–5), were isolated from the leaves of Brucea javanica. The chemical structure was elucidated on the basis of extensive spectroscopic analysis. Compound1 showed significant antimalarial activity (against Plasmodium falciparum strain K1) and cytotoxicity activity against human oral epidermoid carcinoma cancer (KB) and human breast cancer (MCF-7) cell lines with IC50 values 5.54, 2.16, and 1.52 μM, respectively. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Sterols and Flavonoids from the Pelitohalophytes Petrosimonia glaucescens and Climacoptera brachiata
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Coumarin and Flavone Constituents of Chimonanthus salicifolius with Antioxidant Activities
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Flavonoid Glycosides From the Bulbs of Lilium speciosum var . gloriosoides and their Potential Antiviral Activity Against RSV
Bioassay-guided fractionation of the 70% methanolic extract of Lilium speciosum var. gloriosoides Baker resulted in the isolation of a new flavone C-glucoside, speciflavoside A (1), along with four known flavonoids (2 –5). The structures of the isolates were assigned on the basis of spectroscopic data analysis, focusing on interpretation of 1D and 2D NMR, and MS data. All the isolates were tested for antiviral activity against respiratory syncytial virus (RSV). Compound1 showed potent antiviral activity against RSV with IC50 value of 2.9 μg/mL and SI value of 30.9. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Volatile Compounds of Tripleurospermum decipiens from Two Natural Populations in Turkey
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Synthesis, Structure, and Properties of New Lupinine O -Acyl Derivatives
Acylation of the alkaloid lupinine producedO-cinnamoyllupinine andO-lipoyllupinine. The structure ofO-cinnamoyllupinine was established by an X-ray crystal structure analysis. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Phytochemical Constituents of Arenaria kansuensis
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research

Phenol Glycosides and Flavonol Glycosides from the Aerial Part of Zingiber officinale
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 15, 2019 Category: Chemistry Source Type: research