Silymarin Enriched Extract (Silybum marianum) Additive Effect on Doxorubicin-Mediated Cytotoxicity in PC-3 Prostate Cancer Cells
In conclusion, the DXR-SEE co-treatment provokes perturbations in the autophagic mechanism of prostate cancer cells (PC-3) compared to DXR treatment alone, causing an excessive cell death. These findings propose the putative use of SEE as an adjuvant cytotoxic agent. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - July 9, 2019 Category: Drugs & Pharmacology Authors: Gioti, Katerina Papachristodoulou, Anastasia Benaki, Dimitra Havaki, Sophia Beloukas, Apostolos Vontzalidou, Argyro Aligiannis, Nektarios Skaltsounis, Alexios-Leandros Mikros, Emmanuel Tenta, Roxane Tags: Original Papers Source Type: research

Neuroprotective Potential of Ginkgo biloba in Retinal Diseases
Planta Med DOI: 10.1055/a-0947-5712Like other tissues of the central nervous system, the retina is susceptible to damage by oxidative processes that result in several neurodegenerative disease such as age-related macular degeneration, diabetic retinopathy, glaucoma, ischaemic retinal disease, retinal disease produced by light oxidation, and detached retina, among other diseases. The use of antioxidant substances is a solution to some health problems caused by oxidative stress, because they regulate redox homeostasis and reduce oxidative stress. This is important for neurodegeneration linked to oxidation processes. In line ...
Source: Planta Medica - July 2, 2019 Category: Drugs & Pharmacology Authors: Mart ínez-Solís, Isabel Acero, Nuria Bosch-Morell, Francisco Castillo, Encarna Gonz ález-Rosende, María Eugenia Mu ñoz-Mingarro, Dolores Ortega, Teresa Sanahuja, Mar ía Amparo Villagrasa, Victoria Tags: Reviews Source Type: research

Phytochemistry and Antioxidant Activity of Aerial Parts of Phagnalon sordidum L.
Planta Med DOI: 10.1055/a-0953-5984One new natural monoterpene, 5-O-β-d-glucopyranosyl-2-hydroxy-p-cymene (1), and 11 known compounds were isolated through a biologically oriented approach from the aerial parts of Phagnalon sordidum L. The most active extract and fractions were selected using 3 complementary antioxidant activity assays. Results and the different methods were compared by relative antioxidant capacity index. In addition, the most active extract of P. sordidum was subjected to liquid chromatography coupled with electrospray ionization hybrid linear ion trap quadrupole Orbitrap mass spectrometry to quanti...
Source: Planta Medica - July 2, 2019 Category: Drugs & Pharmacology Authors: Cherchar, Hanene Faraone, Immacolata D ʼAmbola, Massimiliano Sinisgalli, Chiara Dal Piaz, Fabrizio Oliva, Patrizia Kabouche, Ahmed Kabouche, Zahia Milella, Luigi Vassallo, Antonio Tags: Original Papers Source Type: research

Chemical Composition and Biological Activities of Essential Oils in the Family Lauraceae: A Systematic Review of the Literature
Planta Med DOI: 10.1055/a-0943-1908The Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from the Lauraceae family. Medline, Scielo, Web of Science, Lilacs, and Scopus were employed to identify articles published between 2000 and 2018, using “Lauraceae”, “essential oil”, and “biological activity” as key ...
Source: Planta Medica - July 1, 2019 Category: Drugs & Pharmacology Authors: Damasceno, Carolina Sette Barbosa Fabri Higaki, Natasha Tiemi Dias, Josiane de F átima Gaspari Miguel, Marilis Dallarmi Miguel, Obdulio Gomes Tags: Reviews Source Type: research

Halimium halimifolium: From the Chemical and Functional Characterization to a Nutraceutical Ingredient Design
Planta Med DOI: 10.1055/a-0953-6007 Halimium halimifolium (Hh) is a shrub used in Algerian folk medicine to treat gastrointestinal pain. An UHPLC-PDA-ESI/MSn method was developed to identify the metabolic profile of the traditionally used infusion (Hh-A) from the aerial parts. The structures of flavanols were confirmed by NMR analysis after the isolation procedure from a hydrohalcolic extract (Hh-B) that also allowed for the identification of phenolic acids, an aryl butanol glucoside, and different derivatives of quercetin, myricetin, and kaempferol. Tiliroside isomers were the chemical markers of Hh-A and Hh-B (54.33 a...
Source: Planta Medica - July 1, 2019 Category: Drugs & Pharmacology Authors: Kerbab, Khawla Sansone, Francesca Zaiter, Lahcene Esposito, Tiziana Celano, Rita Franceschelli, Silvia Pecoraro, Michela Benayache, Fadila Rastrelli, Luca Picerno, Patrizia Aquino, Rita P. Mencherini, Teresa Tags: Original Papers Source Type: research

Cucurbita pepo –Rhus aromatica–Humulus lupulus Combination Reduces Overactive Bladder Symptoms in Women – A Noninterventional Study
Planta Med DOI: 10.1055/a-0946-2280This prospective, noninterventional, multicenter 12-wk study in women with overactive bladder investigated the effectiveness of Granu Fink femina, a herbal combination of seed oil from Uromedic pumpkin (cultivar of Cucurbita pepo), Rhus aromatica (fragrant sumach) bark extract, and Humulus lupulus (hop) cone extract in a clinical setting. Patients documented overactive bladder symptoms and quality of life using questionnaires as well as diaries recording day- and nighttime micturition frequencies, urine leakages during physical activity or at sneezing or coughing, and use of incontinence ...
Source: Planta Medica - July 1, 2019 Category: Drugs & Pharmacology Authors: Gauruder-Burmester, Annett Heim, Stefan Patz, Brigitte Seibt, Stephanie Tags: Original Papers Source Type: research

Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspects
Planta Med DOI: 10.1055/a-0947-5725 Corylus avellana (hazelnut) is one of the most popular tree nuts on a worldwide basis. The main products of C. avellana are kernels, a nutritious food, with a high content of healthy lipids, contained in a hard shell. In recent years, along with the ongoing research carried out on hazelnut kernels, a growing interest has been addressed to the hazelnut byproducts including hazelnut skin, hazelnut hard shell, and hazelnut green leafy cover as well as hazelnut tree leaf. These byproducts deriving from the roasting, cracking, shelling/hulling, and harvesting processes have been found as a...
Source: Planta Medica - June 27, 2019 Category: Drugs & Pharmacology Authors: Bottone, Alfredo Cerulli, Antonietta D ʼUrso, Gilda Masullo, Milena Montoro, Paola Napolitano, Assunta Piacente, Sonia Tags: Reviews Source Type: research

Cytotoxic Cardenolides from the Leaves of Acokanthera oblongifolia
Planta Med DOI: 10.1055/a-0958-2566Three previously undescribed cardenolides, acovenosigenin A 3-O-α-L-acofriopyranoside (1), 14-anhydroacovenosigenin A 3-O-[β-D-glucopyranosyl-(1″→4′)-O-α-L-acofriopyranoside] (2), and 14-anhydroacovenosigenin A 3-O-[β-D-glucopyranosyl-(1″→4′)-O-α-L-acovenopyranoside] (3), together with the two already known ones, 14-anhydrodigitoxigenin 3-O-β-D-glucopyranoside (4) and acospectoside A (5), were isolated from the leaves of Acokanthera oblongifolia. The influence of cardenolides 1 – 3 and acovenoside A (found in the...
Source: Planta Medica - June 27, 2019 Category: Drugs & Pharmacology Authors: Pecio, Łukasz Hassan, Emad M. Omer, Elsayed A. Gajek, Gabriela Kontek, Renata Sobieraj, Andrzej Stochmal, Anna Oleszek, Wies ław Tags: Original Papers Source Type: research

Structural Characterization and Anti-complementary Activities of Two Polysaccharides from Houttuynia cordata
Planta Med DOI: 10.1055/a-0955-7841In previous studies, crude Houttuynia cordata polysaccharides showed beneficial effects on acute lung injury in vivo, a syndrome in which anti-complementary activities played an important role. Anti-complementary activity-guided fractionation of H. cordata polysaccharides led to the isolation of two highly branched homogeneous polysaccharides, HC-PS1 and HC-PS3, with a molecular weight of 274 530 and 216 384 Da, respectively. The polysaccharides were purified by chromatography on DEAE-cellulose and Superdex columns. Their structural characterization was performed by IR, GC-MS, ...
Source: Planta Medica - June 27, 2019 Category: Drugs & Pharmacology Authors: Lu, Yan Zhang, Juan-Juan Huo, Jiang-Yan Chen, Dao-Feng Tags: Original Papers Source Type: research

Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids
Planta Med DOI: 10.1055/a-0953-6738Natural products and their derivatives represent the most consistently successful source of drug leads. Terpenoids, a structurally diverse group, are secondary metabolites widely distributed in nature, endowed with a wide range of biological activities such as antibacterial, anti-inflammatory, antitumoral, or neuroprotective effects, which consolidate their therapeutic value. During the last decades, and taking into consideration the prevalence of aging-related diseases, research activity into the neuroprotective effects of these types of compounds has increased enormously. Several signal...
Source: Planta Medica - June 24, 2019 Category: Drugs & Pharmacology Authors: Gonz ález-Cofrade, Laura de las Heras, Beatriz Apaza, Luis Palomino, Olga M. Tags: Reviews Source Type: research

A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia
Planta Med DOI: 10.1055/a-0953-6165The 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Phytochemical investigations of Ballota and Otostegia species have revealed that diterpenoids are the main constituents of the genera. A large number of flavonoids and other metabolites were also identified. This rev...
Source: Planta Medica - June 19, 2019 Category: Drugs & Pharmacology Authors: Rosselli, Sergio Fontana, Gianfranco Bruno, Maurizio Tags: Reviews Source Type: research

Leaf Decoction of Carica papaya Combined with Artesunate Prevents Recrudescence in Plasmodium berghei-Infected Mice
Planta Med DOI: 10.1055/a-0952-3677Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resistant Plasmodium strains. Despite ACT has been recommended by the World Health Organization since 2001, its overall deployment in poor endemic areas is very slow, principally due to its high cost. In the malaria endemic areas, plant remedies are still widely used mostly withou...
Source: Planta Medica - June 19, 2019 Category: Drugs & Pharmacology Authors: Sannella, Anna Rosa Karioti, Anastasia Stefania, Orsini Aldo, Scalone Luigi, Gradoni Messori, Luigi Severini, Carlo Bilia, Anna Rita Tags: Original Papers Source Type: research

Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum
Planta Med DOI: 10.1055/a-0957-3567As part of our search for new cytotoxic and antimicrobial natural products from endolichenic fungi, 19 compounds including 1 new 10-member lactone (2), 1 new polyacetylene glycoside (3), 1 new brasilane-type sesquiterpenoid glycoside (4), and 2 isobenzofuran-1(3H)-one derivatives (5 and 6) were isolated from the solid culture of the endolichenic fungus Hypoxylon fuscum. Their structures were unambiguously elucidated by NMR spectroscopic data, MS, ECD (electronic circular dichroism) calculation, and chemical methods. The cytotoxic effects on K562, SW480, and HEPG2 cell lines and the antimi...
Source: Planta Medica - June 19, 2019 Category: Drugs & Pharmacology Authors: Basnet, Buddha Bahadur Chen, Baosong Suleimen, Yerlan Melsuly Ma, Ke Guo, Shouyu Bao, Li Huang, Ying Liu, Hongwei Tags: Original Papers Source Type: research

Evaluation of Anti-inflammatory, Antinociceptive, and Antipyretic Activities of Prunus persica var. nucipersica (Nectarine) Kernel
Planta Med DOI: 10.1055/a-0955-5876Nectarine (Prunus persica var. nucipersica) is a worldwide appreciated edible subspecies, with a high nutritional value and benefits on human health due to its phenolic content. Despite the large consumption of the fruit, the potential use of its kernel is poorly studied. Herein, the potential pharmacological activities and the phenolic constituents of an alcoholic extract of kernel nectarine fruits were investigated. Administering nectarine kernel extract (50 and 100 mg/kg, respectively) in rats reduced paw edema after carrageenan injection by 11 and 47% in 1 h, 24 and 33% ...
Source: Planta Medica - June 18, 2019 Category: Drugs & Pharmacology Authors: Elshamy, Abdelsamed Ibrahim Abdallah, Heba Mohammed Ibrahim El Gendy, Abd El-Nasser Gaber El-Kashak, Walla Muscatello, Beatrice De Leo, Marinella Pistelli, Luisa Tags: Original Papers Source Type: research

Metabolic Profiling of Saponin-Rich Ophiopogon japonicus Roots Based on 1H NMR and HPTLC Platforms
In this study, high-performance thin-layer chromatography was used as a supplementary tool for metabolomics. A method consisting of coupling 1H nuclear magnetic resonance spectroscopy and high-performance thin-layer chromatography was applied to distinguish between Ophiopogon japonicus roots that were collected from two growth locations and were of different ages. The results allowed the root samples from the two growth locations to be clearly distinguished. The difficulties encountered in the identification of the marker compounds by 1H nuclear magnetic resonance spectroscopy was overcome using high-performance thin-layer...
Source: Planta Medica - June 17, 2019 Category: Drugs & Pharmacology Authors: Ge, Yanhui Chen, Xiaojia Go đevac, Dejan Bueno, Paula C. P. Salom é Abarca, Luis F. Jang, Young Pyo Wang, Mei Choi, Young Hae Tags: Original Papers Source Type: research

Antcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation
Planta Med DOI: 10.1055/a-0942-2087Antcin-A (ATA) is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea. We previously showed that ATA has strong anti-inflammatory and anti-tumor effects; however, other possible bioactivities of this unique compound remain unexplored. In the present study, we aimed to investigate the modulation of epithelial-to-mesenchymal transition (EMT), anti-migration, and anti-invasive potential of ATA against human breast cancer cells in vitro. Human breast cancer cell lines, MCF-7 and MDA-MB-231, were incubated with ATA for 24 h. W...
Source: Planta Medica - June 11, 2019 Category: Drugs & Pharmacology Authors: Kumar, K. J. Senthil Vani, M. Gokila Hsieh, Han-Wen Lin, Chin-Chung Wang, Sheng-Yang Tags: Original Papers Source Type: research

Higenamine, a Dual Agonist for β 1- and β 2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library
In conclusion, we found an herbal compound, higenamine, to be a dual agonist for β 1/β 2-adrenergic receptors with no preference in stimulating the Gs and Gi pathways in β 2-adrenergic receptor signaling. Our results elucidated not only the target of higenamine to explain its pharmacological effect in treating chronic heart failure, but also the mechanisms of its cardiac toxicity. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - June 11, 2019 Category: Drugs & Pharmacology Authors: Chen, Yanmin Guo, Bujing Zhang, Hongda Hu, Lihong Wang, Jue Tags: Original Papers Source Type: research

ELOM-080 as Add-On Treatment for Respiratory Tract Diseases – A Review of Clinical Studies Conducted in China
Planta Med DOI: 10.1055/a-0942-1993ELOM-080, also known as Myrtol, represents a distillate of a mixture of 4 rectified essential oils: eucalyptus oil, sweet orange oil, myrtle oil, and lemon oil. ELOM-080 is an approved herbal medicinal product for the secretolytic therapy and facilitation of expectoration in acute and chronic bronchitis and for the secretolytic therapy of sinusitis. Its clinical efficacy has been reported by several randomized control trials. Interestingly, in the recent past, a considerable number of clinical studies on the use of ELOM-080 as add-on treatment of different respiratory tract diseases has b...
Source: Planta Medica - June 5, 2019 Category: Drugs & Pharmacology Authors: F ürst, Robert Luong, Betty Thomsen, J örn Wittig, Thomas Tags: Reviews Source Type: research

Effects of Gut Microbiota and Ingredient-Ingredient Interaction on the Pharmacokinetic Properties of Rotundic Acid and Pedunculoside
In this study, we evaluated the pharmacokinetic interactions of rotundic acid with pedunculoside and other ingredients from Ilicis Rotundae Cortex with rotundic acid and pedunculoside, and preliminarily investigated the effects of gut microbiota on their pharmacokinetics using a pseudo-germ-free rat model. After a single oral administration of each monomer, a monomer mixture, and Ilicis Rotundae Cortex extract to the conventional and pseudo-germ-free rats, rotundic acid and pedunculoside were quantified in plasma by an UPLC/Q-TOF-MS/MS method. The systemic exposure (maximum plasma concentration and area under concentration...
Source: Planta Medica - June 5, 2019 Category: Drugs & Pharmacology Authors: Yang, Bao Li, Hui Ruan, Qingfeng Xuan, Shenxin Chen, Xiaojing Cui, Hui Liu, Zhongqiu Jin, Jing Zhao, Zhongxiang Tags: Original Papers Source Type: research

Edgeworthia papyrifera Regulates Osteoblast and Osteoclast Differentiation In Vitro and Exhibits Anti-osteoporosis Activity in Animal Models of Osteoporosis
Planta Med DOI: 10.1055/a-0942-1960Osteoporosis is a clinical condition characterized by low bone strength that leads to an increased risk of fracture. Strategies for the treatment of osteoporosis involve inhibition of bone resorption by osteoclasts and an increase of bone formation by osteoblasts. Here, we identified the extract derived from the stem part of Edgeworthia papyrifera that enhanced differentiation of MC3T3-E1 cells to osteoblast-like cells and inhibited osteoclast differentiation of RAW 264.7 cells in vitro. In support of our observation, rutin and daphnoretin, which were previously reported to inhibit osteoc...
Source: Planta Medica - June 5, 2019 Category: Drugs & Pharmacology Authors: Kim, Pansoo Nam, Yeon-Ju Kim, Woo Jung Kim, Jin Kyu Lee, Gyeongbeen Song, Myung-Jin Yang, Jungeun Yi, Sun Shin Lee, Jong Suk Seo, Jin-Ho Choi, Yongmun Tags: Original Papers Source Type: research

LC-MS- and NMR-Guided Isolation of Monoterpene Dimers from Cultivated Thymus vulgaris Varico 3 Hybrid and Their Antityrosinase Activity
Planta Med DOI: 10.1055/a-0927-7041Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3′,4′-trihydroxy-5,5′-diisopropyl-2,2′-dimethylbiphenyl (1), together with two known p-cymene derivatives (2 and 3), as well as five known compounds, namely, thymol (4), oleanolic acid (5), ursolic acid (6), cirsimaritin (7), and xanthomicrol (8). The structural elucidation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR, and HRESIMS experiments. The biphenyls were...
Source: Planta Medica - June 4, 2019 Category: Drugs & Pharmacology Authors: Stefanis, Ilias Hadjipavlou-Litina, Dimitra Bilia, Anna-Rita Karioti, Anastasia Tags: Original Papers Source Type: research

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile
Planta Med DOI: 10.1055/a-0941-0364In this paper, the isolation of five new guaianolides (1 – 5) and four (6 – 9) known sesquiterpenes from Ormenis mixta aerial parts is reported. The structural determination of the guaianolides was obtained by NMR spectroscopic data, as well as MS experiments. Their relative configurations were assigned by a combined quantum mechanical/NMR approach, comparing the experimental 13C/1H NMR chemical shift data and 1 J H-H homonuclear coupling constants with the related predicted values. The isolates were assayed for their anti-inflammatory potential evaluating nitric...
Source: Planta Medica - June 4, 2019 Category: Drugs & Pharmacology Authors: Benteldjoune, Mounira Chini, Maria Giovanna Iannuzzi, Anna Maria Kabouche, Ahmed Kabouche, Zahia D ʼAmbola, Massimiliano Marzocco, Stefania Autore, Giuseppina Bifulco, Giuseppe De Tommasi, Nunziatina Tags: Original Papers Source Type: research

Plant Latex, from Ecological Interests to Bioactive Chemical Resources
Planta Med DOI: 10.1055/a-0923-8215Historically, latex-bearing plants have been regarded as important medicinal resources in many countries due to their characteristic latex ingredients. They have also often been endowed with a social or cultural significance in religious or cult rituals or for hunting. Initial chemical studies focused on the protein or peptide content but recently the interest extended to smaller molecules. Latex has been found to contain a broad range of specialized metabolites such as terpenoids, cardenolides, alkaloids, and phenolics, which are partly responsible for their antibacterial, antifungal, an...
Source: Planta Medica - May 28, 2019 Category: Drugs & Pharmacology Authors: Salom é Abarca, Luis Francisco Klinkhamer, Peter G. L. Choi, Young Hae Tags: Reviews Source Type: research

Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo
Planta Med DOI: 10.1055/a-0901-1307Abnormal lipid metabolism, such as increased fatty acid uptake and esterification, is associated with nonalcoholic fatty liver disease (NAFLD). The aqueous extract of the aerial part of Angelica tenuissima Nakai (ATX) inhibited high-fat diet–induced hepatic steatosis in mice as well as oleic acid–induced neutral lipid accumulation in HepG2 cells. ATX decreased the mRNA and protein levels of CD36 and diglyceride acyltransferase 2 (DGAT2), the maturation of sterol regulatory element-binding proteins (SREBP), and the expression of the lipogenic target genes fasn and scd1. The ATX...
Source: Planta Medica - May 28, 2019 Category: Drugs & Pharmacology Authors: Lee, Wonseok Koo, Hye Ryoung Choi, You-Jin Choi, Jin Gyu Oh, Myung Sook Jin, Xing Choo, Munki Park, Sunghyouk Jeong, Yoo-Seong Chung, Suk-Jae Lee, Byung-Hoon Tags: Original Papers Source Type: research

A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin
Planta Med DOI: 10.1055/a-0921-7602A fluorometric imaging plate reader (FLIPR) assay utilizing Chinese hamster ovary (CHO) cells stably transfected with GABAA receptors of α 1 β 2 γ 2 subunit composition was evaluated and validated for rapid screening of plant extract libraries and efficient localization of active compounds in extracts. Validation was performed with pure compounds and extracts known to contain allosteric GABAA receptor modulators. Plants extracts that had been previously reported as active in an assay using Xenopus laevis oocytes transiently expressing GABAA receptors of &al...
Source: Planta Medica - May 24, 2019 Category: Drugs & Pharmacology Authors: Faleschini, Maria Teresa Maier, Anne Fankhauser, Sarah Thasis, Katharina Hebeisen, Simon Hamburger, Matthias Butterweck, Veronika Tags: Original Papers Source Type: research

Erratum: Neuroprotective Effects of Dammarane-Type Saponins from Panax notoginseng on Glutamate-Induced Cell Damage in PC12 Cells
Planta Med DOI: 10.1055/a-0916-3473 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 20, 2019 Category: Drugs & Pharmacology Authors: Zhang, Bao-Bao Hu, Xiao-Long Wang, Yu-Yan Li, Jun-Yan Pham, Thi-Anh Wang, Hao Tags: Erratum Source Type: research

The Terroir of Cannabis: Terpene Metabolomics as a Tool to Understand Cannabis sativa Selections
Planta Med DOI: 10.1055/a-0915-2550The phytochemical diversity of Cannabis chemovars is not well understood, and many chemovars were created in informal breeding programs without records of parentage or the criteria for selection. Key criteria for selection sometimes included aroma notes and visual cues, which some breeders associated with pharmacological activity. We hypothesized that the process of selection for scents believed to be related to specific tetrahydrocannabinol levels has resulted in modified terpene biosynthesis in these chemovars. Thirty-two cannabinoids, 29 monoterpenes and 38 sesquiterpenes were measured...
Source: Planta Medica - May 16, 2019 Category: Drugs & Pharmacology Authors: Mudge, Elizabeth M. Brown, Paula N. Murch, Susan J. Tags: Original Papers Source Type: research

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
Planta Med DOI: 10.1055/a-0897-7492Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural o...
Source: Planta Medica - May 7, 2019 Category: Drugs & Pharmacology Authors: R íos, José-Luis And újar, Isabel Schinella, Guillermo R. Francini, Flavio Tags: Reviews Source Type: research

Editorial
Planta Med 2019; 85: 523-523 DOI: 10.1055/a-0874-0254 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - April 29, 2019 Category: Drugs & Pharmacology Authors: Hensel, Andreas Tags: Editorial Source Type: research

High Yield of Bioactive Abietane Diterpenes in Salvia sclarea Hairy Roots by Overexpressing Cyanobacterial DXS or DXR Genes
Planta Med DOI: 10.1055/a-0895-5878Abietane diterpenoids, containing a quinone moiety, are synthesized in the roots of several Salvia species. Promising cytotoxicity and antiproliferative activities have been reported for these compounds in various cell and animal models. We have recently shown that aethiopinone, an o-naphto-quinone diterpene, produced in the roots of different Salvia species, is selectively cytotoxic against the A375 melanoma cell line. To enhance the synthesis of this abietane diterpenoid, we have engineered the plastidial 2-C-methyl-D-erythritol 4-phosphate-derived isoprenoid pathway in Salvia sclarea h...
Source: Planta Medica - April 26, 2019 Category: Drugs & Pharmacology Authors: Vaccaro, Mariacarmela Ocampo Bernal, Vivian Malafronte, Nicola De Tommasi, Nunziatina Leone, Antonietta Tags: Original Papers Source Type: research

Types A and D Trichothecene Mycotoxins from the Fungus Myrothecium roridum
Planta Med DOI: 10.1055/a-0895-5753Chromatographic separation of extracts from the fungal biomass of a plant pathogenic fungus, Myrothecium roridum, yielded 8 trichothecene toxins including 6 type D trichothecenes (1–6) and 2 type A trichothecenes (7–8). 6′,12′-Epoxymyrotoxin A (1) and 7′-hydroxymytoxin B (2) were new macrocyclic trichothecenes, while the other trichothecenes were identified as myrotoxin B (3), myrotoxin D hydrate (4), 2′,3′-epoxymyrothecine A (5), miotoxin A (6), and 2 trichothecenes lacking the macrocyclic lactone system, roridin L-2 (7) and trichoverritone (8). ...
Source: Planta Medica - April 26, 2019 Category: Drugs & Pharmacology Authors: Lakornwong, Waranya Kanokmedhakul, Kwanjai Soytong, Kasem Unartngam, Arm Tontapha, Sarawut Amornkitbamrung, Vittaya Kanokmedhakul, Somdej Tags: Original Papers Source Type: research

Preventive Effects of Total Flavonoid C-Glycosides from Abrus mollis on Nonalcoholic Fatty Liver Disease through Activating the PPAR α Signaling Pathway
In conclusion, total flavonoid C-glycosides are active components of A. mollis on nonalcoholic fatty liver disease, and can be used in functional food and supplements for nonalcoholic fatty liver disease prevention and treatment. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - April 26, 2019 Category: Drugs & Pharmacology Authors: Hu, Xiao-Long Niu, Ya-Jun Chen, Mi Feng, Jia-Hao Shen, Wei Jiang, Zhen-Zhou Zhang, Xiao-Qi Ye, Wen-Cai Xiong, Fei Wang, Hao Tags: Original Papers Source Type: research

Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats
In conclusion, this study demonstrates that a polyphenol extract from mature leaves of Q. ilex improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis, probably through mitogen-activated protein kinase/nuclear transcription factor-kappa B inhibition and Nrf2/heme oxygenase-1 activation signaling pathways, thus reducing the production of Th1 proinflammatory cytokines and cyclooxygenase-2 and inducible nitric oxide synthase overexpression. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - April 24, 2019 Category: Drugs & Pharmacology Authors: Castej ón, Maria Luisa Rosillo, Maria Ángeles Villegas, Isabel S ánchez-Hidalgo, Marina Hadidi, Lila Zaidi, Farid Alarc ón-de-la-Lastra, Catalina Tags: Original Papers Source Type: research

Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells
Planta Med DOI: 10.1055/a-0879-4721Four pairs of β-carboline enantiomers (1a/1b–4a/4b), 2 β-carboline derivatives (5 – 6) with a single enantiomeric configuration, together with 2 known achiral congeners (7 – 8) were isolated from the stems of Picrasma quassioides. Their structures were elucidated on the basis of extensive spectroscopic analyses and quantum mechanical calculations. Compound 5 possesses a 4,5-seco β-carboline framework and represents the first example of this type of β-carboline alkaloids from nature. A possible biosynthetic pathway is proposed to generate the r...
Source: Planta Medica - April 11, 2019 Category: Drugs & Pharmacology Authors: Zhao, Wen-Yu Chen, Jing-Jie Zou, Chun-Xin Zhou, Wei-Yu Yao, Guo-Dong Wang, Xiao-Bo Lin, Bin Huang, Xiao-Xiao Song, Shao-Jiang Tags: Original Papers Source Type: research

Antiangiogenic Iridoids from Stachys ocymastrum and Premna resinosa
Planta Med DOI: 10.1055/a-0889-0412In this paper, the isolation of one new iridoid glucoside, 6β-acetoxyipolamiide (1), and thirteen (2 – 14) known congeners from two Lamiaceae species, Stachys ocymastrum and Premna resinosa, leaf extracts is reported. The structural determination of the isolated compounds was performed by mono- and bidimensional NMR spectroscopic analysis as well as MS experiments. The isolates were assayed for their antiangiogenic activity by two in vivo models, zebrafish embryos and chick chorioallantoic membrane assays. The compounds with a significant antiangiogenic activity in both ass...
Source: Planta Medica - April 9, 2019 Category: Drugs & Pharmacology Authors: Iannuzzi, Anna Maria Camero, C ésar Muñoz D ʼAmbola, Massimiliano D ʼAngelo, Valeria Amira, Smain Bader, Ammar Braca, Alessandra De Tommasi, Nunziatina German ò, Maria Paola Tags: Original Papers Source Type: research

O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity
Planta Med DOI: 10.1055/a-0883-5383A general protocol for the selective mono-O-methylation of resorcinyl phytocannabinoids was developed. The availability of semisynthetic monomethyl analogues of cannabigerol, cannabidiol, and cannabidivarin (1a–3a, respectively) made it possible to quantify these minor phytocannabinoids in about 40 different chemotypes of fiber hemp. No chemotype significantly accumulated mono-O-methyl cannabidiol (2b) or its lower homologue (3b), while at least three chemotypes containing consistent amounts (≥ 400 mg/kg) of O-methylcannabigerol (1b) were identified. O-Methylation o...
Source: Planta Medica - April 1, 2019 Category: Drugs & Pharmacology Authors: Caprioglio, Diego Allegrone, Gianna Pollastro, Federica Valera, Stefano Lopatriello, Annalisa Collado, Juan A. Munoz, Eduardo Appendino, Giovanni Taglialatela-Scafati, Orazio Tags: Original Papers Source Type: research

Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications
Planta Med DOI: 10.1055/a-0857-6633Cosmeceuticals are designed to serve a dual purpose: to provide desired esthetical effects and to treat dermatological conditions. Natural products derived from plants and marine organisms are a novel source of potential cosmeceutical active ingredients for incorporation into new formulations due to consumer demands. Contrary to common perceptions, most regulatory agencies do not view cosmeceuticals as being a separate category from cosmetics; thus, these products are not regulated accordingly, thereby forcing the consumer to rely on the self-regulatory policies of the cosmetics industry....
Source: Planta Medica - March 29, 2019 Category: Drugs & Pharmacology Authors: Espinosa-Leal, Claudia A. Garcia-Lara, Silverio Tags: Reviews Source Type: research

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers
In conclusion, standardized extracts of B. serrata exert its wound healing potential via orchestrating mechanisms, which include the inhibition of oxido-inflammatory markers (oxido-nitrosative stress, TNF-α, interleukins, and nuclear factor-kappa-light-chain-enhancer of activated B cells), increased collagen synthesis (hydroxyproline and collagen-1) and angiogenesis (Ang-1/Tie2), promoting growth factors (transforming growth factor beta 1 and vascular endothelial growth factor), and inhibition of apoptosis (Bcl-2-associated X protein) to accelerate wound healing in experimental delayed diabetic foot ulcer. [...] Geor...
Source: Planta Medica - March 25, 2019 Category: Drugs & Pharmacology Authors: Pengzong, Zhang Yuanmin, Li Xiaoming, Xiong Shang, Deng Wei, Xiong Zhigang, Lang Dongzhou, Du Wenjing, Yu Jianbiao, Yue Yang, Xiang Xia, Li Tags: Original Papers Source Type: research

Antiplasmodial Lycorane Alkaloid Principles of the Plant Family Amaryllidaceae
Planta Med DOI: 10.1055/a-0880-5414The spread of malaria is thought to have followed human expansion out of Africa some 60 – 80 thousand years ago. With its prevalence in pantropical countries of the world and epicenter localized in Africa, malaria is now considered an unnecessary burden to overworked and under-resourced healthcare structures. Plants have long afforded a fertile hunting ground for the search and identification of structurally diverse antimalarial agents, such as quinine and artemisinin. This survey examines the antiparasitic properties of the family Amaryllidaceae via the antiplasmodial activitie...
Source: Planta Medica - March 25, 2019 Category: Drugs & Pharmacology Authors: Nair, Jerald J. van Staden, Johannes Tags: Original Papers Source Type: research

Development and Validation of a UHPLC-DAD Method for the Quantitative Analysis of Major Dihydrochalcone Glucosides from Thonningia sanguinea VAHL
In this study, an ultrahigh-performance liquid chromatographic method coupled with a photodiode array detector was developed for the quantitation of six major dihydrochalcone derivatives. The analytes were baseline separated in complex samples within 14 minutes on a Phenomenex Luna Omega 1.6 µm C18 column using a mobile phase consisting of water and acetonitrile (each + 0.01% trifluoroacetic acid) in gradient elution. Method validation confirmed the selectivity, linearity (R2 ≥ 0.9992), precision (inter-day ≤ 1.98%, intraday ≤ 2.00%), and accuracy (recovery rates of ...
Source: Planta Medica - March 22, 2019 Category: Drugs & Pharmacology Authors: Pompermaier, Luca Schwaiger, Stefan Mawunu, Monizi Lautenschlaeger, Thea Stuppner, Hermann Tags: Original Papers Source Type: research

The Nonvolatile and Volatile Metabolites of Prangos ferulacea and Their Biological Properties
Planta Med DOI: 10.1055/a-0873-8622 Prangos ferulacea (L.) Lindl. (Fam. Apiaceae), an orophilous species of eastern Mediterranean and western Asia, possesses a number of biological properties that are worthy of exploitation in different fields. Phytochemical investigations revealed the presence of coumarins, prenyl-coumarins, and furano-coumarins as the main constituents of this species, as well as several flavonoids. Among prenyl-coumarins, osthol is a promising apoptotic agent quite selective toward cancer cells. In addition, the essential oils have been extensively investigated, and several chemotypes have been ident...
Source: Planta Medica - March 20, 2019 Category: Drugs & Pharmacology Authors: Bruno, Maurizio Ilardi, Vincenzo Lupidi, Giulio Quassinti, Luana Bramucci, Massimo Fiorini, Dennis Venditti, Alessandro Maggi, Filippo Tags: Reviews Source Type: research

Plant Allergen-Induced Contact Dermatitis
Planta Med DOI: 10.1055/a-0873-1494Although manifold beneficial effects of plant compounds for the treatment of skin disorders are known, cutaneous exposure to plants can also result in various types of incompatibility reactions such as contact dermatitis. In this mini-review, we briefly describe the different clinical forms of contact dermatitis (photoinduced, irritative, and allergic form) and highlight recent publications in the field of contact dermatitis. Major topics are recent recommendations regarding testing for plant contact dermatitis, advances in understanding the immunological mechanisms of plant contact derma...
Source: Planta Medica - March 15, 2019 Category: Drugs & Pharmacology Authors: Esser, Philipp R. Mueller, Sabine Martin, Stefan F. Tags: Reviews Source Type: research

The Wound Healing Properties of Betulin from Birch Bark from Bench to Bedside
Planta Med DOI: 10.1055/a-0850-0224With central European approval in January 2016 for a betulin-oleogel (Episalvan), used to accelerate wound closure in partial thickness wounds, the herbal active ingredient triterpene dry extract (betulin), from birch bark, was introduced into therapy for the first time. Clinical evidence of accelerated wound healing was provided in a new study design by means of intraindividual comparison of split-thickness skin graft donor wounds and burn wounds. Clinical results of a phase II study evidencing accelerated wound healing in the rare disease epidermolysis bullosa are also available, and a ...
Source: Planta Medica - March 11, 2019 Category: Drugs & Pharmacology Authors: Scheffler, Armin Tags: Reviews Source Type: research

Structure-Activity Relationship of Transfection-Modulating Saponins – A Pursuit for the Optimal Gene Trafficker
Planta Med DOI: 10.1055/a-0863-4795 The ability of certain triterpenoid saponins to modulate the endosomal release during the process of endocytosis and to ensure a nontoxic and efficient transfection recently led to an exceptional interest in the field of nonviral gene delivery. In vitro and in vivo studies demonstrated promising results in terms of tumor growth inhibition after the delivery of a suicide gene such as saporin and dianthin. With that, the question arises which structural features are necessary or advantageous to achieve an effective endosomal escape. Former studies described certain important characteristic...
Source: Planta Medica - March 1, 2019 Category: Drugs & Pharmacology Authors: Sama, Simko Jerz, Gerold Thakur, Mayank Melzig, Matthias F. Weng, Alexander Tags: Rapid Communications Source Type: research

Magnesium Lithospermate B Derived from Salvia miltiorrhiza Ameliorates Right Ventricle Remodeling in Pulmonary Hypertensive Rats via Inhibition of NOX/VPO1 Pathway
This study aims to investigate whether MLB is able to prevent RV remodeling in PAH and the underlying mechanisms. In vivo, SD rats were exposed to 10% O2 for 21 d to induce RV remodeling, which showed hypertrophic features (increases in the ratio of RV weight to tibia length, cellular size, and hypertrophic marker expression), accompanied by upregulation in expression of NADPH oxidases (NOX2 and NOX4) and vascular peroxidase 1 (VPO1), increases in hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) production and elevation in phosphorylation levels of ERK; these changes were attenuated by treating rats with MLB. I...
Source: Planta Medica - March 1, 2019 Category: Drugs & Pharmacology Authors: Li, Tao Peng, Jing-Jie Wang, E-Li Li, Nian-Sheng Song, Feng-Lin Yang, Jin-Fu Luo, Xiu-Ju Liu, Bin Peng, Jun Tags: Original Papers Source Type: research

Erratum: New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities
Planta Med DOI: 10.1055/a-0865-9074 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - March 1, 2019 Category: Drugs & Pharmacology Authors: de Amorim, Marcelo R. Hil ário, Felipe dos Santos, Fernando M. Batista, Jo ão M. Bauab, Tais M. Ara újo, Angela R. Carlos, Iracilda Z. Vilegas, Wagner dos Santos, Lourdes C. Tags: Erratum Source Type: research

Editorial
Planta Med 2019; 85: 273-273 DOI: 10.1055/a-0832-5297 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - February 26, 2019 Category: Drugs & Pharmacology Authors: Kayser, Oliver F ürst, Robert Tags: Editorial Source Type: research

Neuroprotective Effects of Dammarane-Type Saponins from Panax notoginseng on Glutamate-Induced Cell Damage in PC12 Cells
Planta Med DOI: 10.1055/a-0853-7754Dammarane-type saponins, the main active ingredients of Panax notoginseng, have substantial neuroprotective effects in different animal models of neurodegenerative diseases. However, because these compounds have different structures, the level of protection provided by individual compounds varies, and highly active compounds can be selected based on structure-activity relationships. Glutamate is a major excitatory neurotransmitter that plays an important role in synaptic response development. However, excessive extracellular glutamate levels lead to neuronal dysfunctions in the central ne...
Source: Planta Medica - February 21, 2019 Category: Drugs & Pharmacology Authors: Zhang, Bao-Bao Hu, Xiao-Long Wang, Yu-Yan Li, Jun-Yan Pham, Thi-Anh Wang, Hao Tags: Original Papers Source Type: research

Cytotoxic Alkaloids from Leaves of Pilea aff. martinii
Planta Med DOI: 10.1055/a-0826-0483Two new phenanthroquinolizidine alkaloids (1 and 2) and a new piperidine derivative (3) were isolated from the leaves of Pilea aff. martinii together with 3 known alkaloids: julandine (4), cryptopleurine (5), and 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one (6). Their structures were determined by spectral data analyses including mass spectrometry and 2-dimensional nuclear magnetic resonance data. The absolute configurations of 1–3 were established by comparison of their experimental circular dichroism data with the calculated electronic circular dichroism spectra. The i...
Source: Planta Medica - February 21, 2019 Category: Drugs & Pharmacology Authors: Doan Thi Thuy, Ai Trinh Thi Thanh, Van Doan Thi Mai, Huong Le, Huyen Tram Litaudon, Marc Nguyen, Van Hung Chau, Van Minh Pham, Van Cuong Tags: Original Papers Source Type: research

Erratum: Brazilian Plants: An Unexplored Source of Endophytes as Producers of Active Metabolites
Planta Med DOI: 10.1055/a-0861-1595 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - February 21, 2019 Category: Drugs & Pharmacology Authors: Savi, Daiani Cristina Aluizio, Rodrigo Glienke, Chirlei Tags: Erratum Source Type: research