A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity
Planta Med DOI: 10.1055/a-1196-1906Fungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attracti...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Li, Xiu-Qi Xu, Kuo Liu, Xin-Min Zhang, Peng Tags: Reviews Source Type: research

Molecular Identification Based on Chloroplast Sequences and Anti-complementary Activity Comparison of Juniperus Samples from the Qinghai-Tibet Plateau
Planta Med DOI: 10.1055/a-1194-0471 Juniperus (Cupressaceae, Pinales) plants are widely distributed in the Qinghai-Tibet Plateau of China. The leaves and twigs of at least 8 Juniperus species (J. pingii, J. pingii var. wilsonii, J. squamata, J. recurva var. coxii, J. saltuaria, J. indica, J. tibetica and J. convallium var. microsperma) have been used as the Tibetan medicine Xuba. At present, it is difficult to distinguish among the original species of Xuba based only on their similar morphological characteristics. However, in our previous studies, 4 Xuba samples from different Juniperus species exhibited significant dif...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Yang, Yi-Ting De, Ji Fu, Ze-Long Wang, Xie-Li Chen, Dao-Feng Xie, Hui Lu, Yan Tags: Original Papers Source Type: research

Cytotoxic and Anti-inflammatory Terpenoids from the Whole Plant of Vaccinium emarginatum
Planta Med DOI: 10.1055/a-1192-6225Two new Δ12 ursene-type triterpenoid coumaroyl esters (1 and 2), one new Δ7,15 isopimarane-type diterpenoid glycoside (20), and two new irido-δ-lactone-type iridoids (21 and 22), together with 17 known pentacyclic triterpenoids (3 – 19), were isolated during the phytochemical investigation of a methanol extract of the whole plant of Vaccinium emarginatum. Their structures were determined by detailed analysis of standard spectroscopic data (MS, IR, 1D, and 2D NMR) and comparison with data of known analogs. The isolates were evaluated for their cytotoxicity again...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Tu, Ping-Chen Liang, Yu-Chia Huang, Guan-Jhong Lin, Ming-Kuem Kao, Ming-Ching Lu, Te-Ling Sung, Ping-Jyun Kuo, Yueh-Hsiung Tags: Original Papers Source Type: research

Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites
In this study, we evaluated the bactericidal, antiprotozoal, and cathepsin V inhibition activities of extracts from axenic cultures of 6 fungi (Fusarium guttiforme, Pestalotiopsis diospyri, Phoma caricae-papayae, Colletotrichum horii, Phytophthora palmivora, and C. gloeosporioides) that infest tropical fruits and 57 extracts obtained by their cocultivation. Our results reveal that fungal cocultivation enhances the biological activity of the samples, since all extracts that were active on Gram-positive bacteria, Gram-negative bacteria, Trypanosoma cruzi, and Leishmania infantum were obtained from cocultivation. Bacteri...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Silva, Airton Damasceno Ambrozin, Alessandra Regina Pepe de Camargo, Ana Fl ávia S. Cruz, Felipe De Paula Nogueira Ferreira, Leonardo Luiz Gomes Krogh, Renata Silva, Taynara Lopes Camargo, Ilana Lopes Baratella da Cunha Andricopulo, Adriano Defini Vieira Tags: Original Papers Source Type: research

Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice
In conclusion, these findings suggest that cacao bean polyphenols prevent pressure overload-induced cardiac hypertrophy and systolic dysfunction by inhibiting the extracellular signal-regulated kinase 1/2-GATA binding protein 4 pathway in cardiomyocytes. Thus, cacao bean polyphenols may be useful for heart failure therapy in humans. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Sari, Nurmila Katanasaka, Yasufumi Honda, Hiroki Miyazaki, Yusuke Sunagawa, Yoichi Funamoto, Masafumi Shimizu, Kana Shimizu, Satoshi Wada, Hiromichi Hasegawa, Koji Morimoto, Tatsuya Tags: Original Papers Source Type: research

Syzygium aromaticum Reduces Diabetes-induced Glucotoxicity via the NRF2/Glo1 Pathway
In this study, we determined the inhibitory effects of S. aromaticum on AGE formation. Moreover, S. aromaticum showed breakage and inhibitory ability against the formation of AGE-collagen crosslinks. In SV40 MES13 cells, treatment with the S. aromaticum extract significantly ameliorated MG-induced oxidative stress as well as cytotoxicity. Furthermore, in the S. aromaticum extract-treated group, there was a reduction in levels of several diabetic markers, such as blood glucose, kidney weight, and urinary albumin to creatinine ratio in streptozotocin-induced diabetic rats. Treatment with the S. aromaticum extr...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Do, Moon Ho Choi, Jiwon Kim, Yoonsook Ha, Sang Keun Yoo, Guijae Hur, Jinyoung Tags: Original Papers Source Type: research

Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets
Planta Med DOI: 10.1055/a-1197-2898 Helianthemum nummularium is a European shrub growing at high altitude where it copes with a high level of stress. It was found to be overexpressed in ungulates diets compared to more abundant surrounding plants. These elements combined with the fact that H. nummularium from the Alps has never been investigated prompted us to study the phytochemical composition of its aerial parts. The analysis of the polar extract allowed for the isolation of eight compounds: p-hydroxybenzoic acid, tiliroside, kaempferol, astragalin, quercetin, plantainoside B, quercetin-3-O-glucoside, and quercetin-3...
Source: Planta Medica - July 9, 2020 Category: Drugs & Pharmacology Authors: Agostini, Mathieu Hininger-Favier, Isabelle Marcourt, Laurence Boucherle, Benjamin Gao, Bifeng Hybertson, Brooks M. Bose, Swapan K. McCord, Joe M. Millery, Annie Rome, Maxime Ferreira Queiroz, Emerson Wolfender, Jean-Luc Gallet, Christiane Boumendjel, Ahc Tags: Original Papers Source Type: research

New Endophytic Fusarium spp. from Fraxinus excelsior Leaves in Slovakia
In this study, new endophytic Fusarium spp. isolate Fraxinus excelsior Fusarium from Slovak territory, associated with F. excelsior, was characterised. Using morphology-based approaches, the fungus was assigned to the genus Fusarium. The isolate formed thick-walled hyaline, fusiform, slightly curved macroconidia, produced from monophialides in sporodochia, pointed at the tip, mostly 3 – 5 septate, occasionally 6 septate, and 40 – 68 × 3.8 – 5.0 µm in size with basal pedicellate cells. For more accurate taxonomic affiliation, molecular sequence analyses of ...
Source: Planta Medica - June 24, 2020 Category: Drugs & Pharmacology Authors: Ivanova, Helena Malinicova, Lenka Piknova, Maria Pristas, Peter Tags: Original Papers Source Type: research

Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors
Planta Med DOI: 10.1055/a-1178-0852 Artemisia annua tea is a popular dosage form used to treat and prevent malaria in some developing countries. However, repeated drinking leads to an obviously decreased efficacy, which may be related to the induction of metabolizing enzymes by artemisinin. In the present study, the ability of different components in A. annua to activate the pregnane X receptor and constitutive androstane receptor was evaluated by the dual luciferase reporter gene system. The changes in mRNA and protein expression of CYP3A4 and CYP2B6 were determined by quantitative real-time PCR and Western blotti...
Source: Planta Medica - June 17, 2020 Category: Drugs & Pharmacology Authors: Zhang, Xueli Meng, Ran Wang, Haina Xing, Jie Tags: Original Papers Source Type: research

Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots
In this study, antioxidant and antibacterial properties of aqueous fractions of three endophytic fungi isolated from the roots of 8-year-old Scots pines (Pinus sylvestris) growing on a drained peatland were investigated. The endophytic fungi species were Acephala applanata, Phialocephala fortinii, and Humicolopsis cephalosporioides/Coniochaeta mutabilis. The bioactivities were examined using hydrogen peroxide scavenging and oxygen radical absorbance capacity tests as well as sensitive Escherichia coli-based biosensors, which produce a luminescent signal in the presence of substances with oxidative or genotoxic properties. ...
Source: Planta Medica - June 10, 2020 Category: Drugs & Pharmacology Authors: Tienaho, Jenni Karonen, Maarit Muilu-M äkelä, Riina Kaseva, Janne de Pedro, Nuria Vicente, Francisca Genilloud, Olga Aapola, Ulla Uusitalo, Hannu Vuolteenaho, Katriina Franz én, Robert W ähälä, Kristiina Karp, Matti Santala, Ville Sarjala, Tytti Tags: Original Papers Source Type: research

ELISA for the Detection of the Prohibited Doping Agent Higenamine
Planta Med DOI: 10.1055/a-1181-2084Higenamine is a natural benzyltetrahydroisoquinoline alkaloid produced by various plants. In the World Anti-Doping Agency report of 2020, higenamine is classified as a class S3 (selective and nonselective β2-agonist) prohibited substance. To minimize the problems resulting from the misuse of higenamine-containing products as well as from the abuse of doping agents in sport, numerous higenamine-detection methods have been investigated. In the present study, a monoclonal antibody against the (S)-enantiomer of higenamine was successfully produced and applied in the indirect competitive ...
Source: Planta Medica - June 8, 2020 Category: Drugs & Pharmacology Authors: Nuntawong, Poomraphie Tanaka, Hiroyuki Sakamoto, Seiichi Morimoto, Satoshi Tags: Original Papers Source Type: research

Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway
In this study, we investigated the antitumor effect of daucosterol linolenate extracted from sweet potato and its potential mechanism. An MTT assay indicated that DLA inhibited the proliferation of breast cancer MCF-7 cells but had only weak effects on the proliferation of MDA-MB-231, 4T1, and MCF-10A cells. Flow cytometry analysis revealed that daucosterol linolenate induced apoptosis of MCF-7 cells. Experiments with MCF-7 xenograft in nude mice further confirmed that DLA inhibited tumor growth dose-dependently. After DLA treatment, the expressions of B-cell lymphoma 2 and vascular endothelial growth factor were decreased...
Source: Planta Medica - June 8, 2020 Category: Drugs & Pharmacology Authors: Han, Bing Jiang, Lingmin Jiang, Pu Zhou, Deqi Jia, Xiaoxin Li, Xuegang Ye, Xiaoli Tags: Original Papers Source Type: research

Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity
Planta Med DOI: 10.1055/a-1179-1003Ten lignans (1 – 10) were isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Three of them, cubebin dimethyl ether (3), urinatetralin (4), and lintetralin (7) are described for the first time in this species, while phyllanthin (1), niranthin (2), 5-demethoxyniranthin (5), isolintetralin (6), hypophyllanthin (8), nirtetralin (9), and phyltetralin (10) have been already reported from P. amarus. Among the lignans tested against Trypanosoma cruzi intracellular amastigotes, 2 was the most active with an EC50 of 35.28 µM. Lignans 2, 5, 7, and 9 s...
Source: Planta Medica - June 8, 2020 Category: Drugs & Pharmacology Authors: Conrado, Gabrielly Galdino Grazzia, Nathalia de Oliveira, Adriana da Silva S. Franco, Caio Haddad Moraes, Carolina Borsoi Gadelha, Fernanda Ramos Miguel, Danilo Ciccone Garcia, Vera Lucia Tags: Original Papers Source Type: research

Differentiation between Cistus L. (Sub-) Species (Cistaceae) Using NMR Metabolic Fingerprinting
Planta Med DOI: 10.1055/a-1176-1937The genus Cistus is taxonomically complex, as taxonomic classification of individual species based on morphological criteria is often difficult and ambiguous. However, specific species contain valuable natural products, especially terpenoids and polyphenols, which exert various biological effects and might therefore be used for treatment of a broad array of disorders. Hence, a fast and reliable method for clear identification of different Cistus (sub-) species is required. Approaches for analysis of secondary metabolite profiles, e.g., with NMR, might remedy the challenging classification...
Source: Planta Medica - June 3, 2020 Category: Drugs & Pharmacology Authors: Moosmang, Simon Sturm, Sonja Novak, Johannes Lukas, Brigitte Stuppner, Hermann Tags: Original Papers Source Type: research

Characterization of a Structural Leoligin Analog as Farnesoid X Receptor Agonist and Modulator of Cholesterol Transport
In conclusion, the leoligin analog LT-141A selectively activates the nuclear receptor farnesoid X receptor and has an influence on cholesterol transport in 2 model systems. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - June 2, 2020 Category: Drugs & Pharmacology Authors: Ladurner, Angela Linder, Thomas Wang, Limei Hiebl, Verena Schuster, Daniela Schn ürch, Michael Mihovilovic, Marko D. Atanasov, Atanas G. Dirsch, Verena M. Tags: Original Papers Source Type: research

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense
Planta Med DOI: 10.1055/a-1179-1050Chemical investigation of the lichen Parmotrema tsavoense led to the isolation of 5 new depsidones, parmosidones F – J (1 – 5). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3, and 4 were evaluated for their inhibition of α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 µM, which was much lower than that of the positive control acarbose (IC50 449 µM). [...] Georg Thieme Verlag KG Stuttgart &midd...
Source: Planta Medica - May 29, 2020 Category: Drugs & Pharmacology Authors: Duong, Thuc-Huy Hang, Tai-Xuan-Hoa Pogam, Pierre Le Tran, Thanh-Nha Mac, Dinh-Hung Dinh, Minh-Hiep Sichaem, Jirapast Tags: Original Papers Source Type: research

Characterization of Antibacterial Proanthocyanidins of Dalbergia monetaria, an Amazonian Medicinal Plant, by UHPLC-HRMS/MS
Planta Med DOI: 10.1055/a-1170-8016 Dalbergia monetaria is an Amazonian plant whose bark is widely used to treat urinary tract infections. This paper describes a bio-guided study of ethanolic extracts from the bark and leaves of D. monetaria, in a search for metabolites active against human pathogenic bacteria. In vitro assays were performed against 10 bacterial strains, highlighting methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Fractioning of the extracts was performed using instrumental and classical techniques, and samples were characterized by...
Source: Planta Medica - May 29, 2020 Category: Drugs & Pharmacology Authors: de Moura, Patricia Homobono Brito de Sousa, Amaryllis Almeida Porzel, Andrea Wessjohann, Ludger A. Leal, Ivana Correa Ramos Martins, Roberto Carlos Campos Tags: Original Papers Source Type: research

Editorial
Planta Med DOI: 10.1055/a-1182-5301 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 26, 2020 Category: Drugs & Pharmacology Authors: Kayser, Oliver F ürst, Robert Tags: Editorial Source Type: research

Volatile Antimicrobial Agents and In Vitro Methods for Evaluating Their Activity in the Vapour Phase: A Review
Planta Med DOI: 10.1055/a-1158-4529This review summarizes data on the in vitro antimicrobial effectiveness of volatile agents of plant origin and in vitro methods for evaluating their activity in the vapour phase. As a result of literature analysis, the antimicrobial efficacy of vapours from 122 different plant species and 19 pure compounds examined in 61 studies using different in vitro tests against a broad spectrum of microorganisms was identified and summarized. In addition, 11 different techniques found in the literature are described in detail. An original classification of methods based on the solid and liquid matri...
Source: Planta Medica - May 25, 2020 Category: Drugs & Pharmacology Authors: Houdkova, Marketa Kokoska, Ladislav Tags: Reviews Source Type: research

Wild Strawberry, Blackberry, and Blueberry Leaf Extracts Alleviate Starch-Induced Hyperglycemia in Prediabetic and Diabetic Mice
Planta Med DOI: 10.1055/a-1164-8152Intestinal α-glucosidase and α-amylase break down nutritional poly- and oligosaccharides to monosaccharides and their activity significantly contributes to postprandial hyperglycemia. Competitive inhibitors of these enzymes, such as acarbose, are effective antidiabetic drugs, but have unpleasant side effects. In our ethnopharmacology inspired investigations, we found that wild strawberry (Fragaria vesca), blackberry (Rubus fruticosus), and European blueberry (Vaccinium myrtillus) leaf extracts inhibit α-glucosidase and α-amylase enzyme activity in vitro and are eff...
Source: Planta Medica - May 25, 2020 Category: Drugs & Pharmacology Authors: Tak ács, István Szekeres, Andr ás Tak ács, Ákos Rakk, D ávid M ézes, Miklós Poly ák, Ágnes Lakatos, L óránt Gy émánt, Gyöngyi Csupor, Dezs ő Kov ács, Krisztina J. Ferenczi, Szilam ér Tags: Original Papers Source Type: research

Characterization of Maca (Lepidium meyenii/Lepidium peruvianum) Using a Mass Spectral Fingerprinting, Metabolomic Analysis, and Genetic Sequencing Approach
Planta Med DOI: 10.1055/a-1161-0372Maca (Lepidium meyenii, synonym L. peruvianum) was analyzed using a systematic approach employing principal component analysis of flow injection mass spectrometry fingerprints (no chromatographic separation) to guide the selection of samples for metabolite profiling and DNA next generation sequencing. Samples consisted of 39 commercial maca supplements from 11 manufacturers, 31 unprocessed maca tubers grown in Peru and China, and a historic non-tuber maca sample from Peru. Principal component analysis of flow injection mass spectrometry fingerprints initially placed all the maca samp...
Source: Planta Medica - May 20, 2020 Category: Drugs & Pharmacology Authors: Geng, Ping Sun, Jianghao Chen, Pei Brand, Eric Frame, James Meissner, Henry Stewart, Jeremy Gafner, Stefan Clark, Stephanie Miller, Jesse Harnly, James Tags: Original Papers Source Type: research

Challenges at the Time of COVID-19: Opportunities and Innovations in Antivirals from Nature
Planta Med DOI: 10.1055/a-1177-4396As viral infections are an increasing threat to human societies, the need for new therapeutic strategies is becoming even more obvious. As no vaccine is available for COVID-19, the development of directly acting antiviral agents and preventive strategies have to be considered. Nature provides a huge reservoir of anti-infectious compounds, from which we can deduce innovative ideas, therapies, and products. Anti-adhesive natural products interact with the receptor-mediated recognition and early interaction of viruses with the host cells, leading to a reduced internalisation of the virus and...
Source: Planta Medica - May 20, 2020 Category: Drugs & Pharmacology Authors: Hensel, Andreas Bauer, Rudolf Heinrich, Michael Spiegler, Verena Kayser, Oliver Hempel, Georg Kraft, Karin Tags: Natural Product Chemistry and Analytical Studies Source Type: research

Artemisiae Iwayomogii Herba Inhibits Growth, Motility, and the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma Cells
In this study, the Artemisiae Iwayomogii Herba ethanol extract was investigated for the ability to inhibit growth of hepatocellular carcinoma and its underlying mechanism involved. The antiproliferative effect of Artemisiae Iwayomogii Herba ethanol extract was evaluated using cell viability and proliferation assays. The effect of Artemisiae Iwayomogii Herba ethanol extract on apoptosis was measured using western blotting, terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling staining, JC-1 staining, cytochrome c release, immunohistochemistry, and immunofluorescence in ex vivo mouse xenografts. Artemisiae ...
Source: Planta Medica - May 19, 2020 Category: Drugs & Pharmacology Authors: Kim, Juyoung Jung, Kyung Hee Choi, Jin Gyu Oh, Myung Sook Hong, Soon-Sun Tags: Original Papers Source Type: research

Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment
Planta Med DOI: 10.1055/a-1170-7785The pomegranate phenolics are reported to have cutaneous benefits and to be effective in treating skin disorders, including hyperpigmentation. In this context, a preparation method was developed by which to obtain phenolic-rich pomegranate peel extract. Sinapic acid was presented as the major pomegranate peel phenolics, followed by gallic and ellagic acids, and 4 additional phenolics. The extract exhibited strong antioxidant activity with an in vitro tyrosinase inhibitory effect. The skin hyperpigmentation treating potency was confirmed by the suppression of cellular melanogenesis through...
Source: Planta Medica - May 19, 2020 Category: Drugs & Pharmacology Authors: Kanlayavattanakul, Mayuree Chongnativisit, Wichayada Chaikul, Puxvadee Lourith, Nattaya Tags: Original Papers Source Type: research

Herbal Products in Postsurgical Wound Healing – Incision, Excision and Dead Space Wound Models
Planta Med DOI: 10.1055/a-1162-9988The purpose of this review is to summarize current knowledge acquired on preclinical (incision, excision, and dead space wound models) and clinical studies regarding topically used herbal products with wound healing activity. The antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as the adverse effects of herbal therapy will be described. Numerous preclinical and few clinical trials have confirmed the activity of herbal products in the stimulation of wound healing. In contrast to synthetic drugs, for which chemical compositions, purity, efficacy, minimal ...
Source: Planta Medica - May 18, 2020 Category: Drugs & Pharmacology Authors: Herman, Anna Herman, Andrzej P. Tags: Reviews Source Type: research

Erratum: Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea
Planta Med DOI: 10.1055/a-1177-3691 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 18, 2020 Category: Drugs & Pharmacology Authors: Guzm án-Gutiérrez, Silvia Laura Silva-Miranda, Mayra Krengel, Felix Huerta-Salazar, Elizabeth Le ón-Santiago, Mayra D íaz-Cantón, Jessica Karina Espitia Pinz ón, Clara Reyes-Chilpa, Ricardo Tags: Erratum Source Type: research

Ginkgo biloba and Its Constituent 6-hydroxykynurenic-acid as well as Its Proanthocyanidins Exert Neurorestorative Effects against Cerebral Ischemia
Planta Med DOI: 10.1055/a-1146-2861Neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury by Ginkgo biloba leaves are commonly attributed to the antioxidant activity of its proanthocyanidins. Furthermore, preliminary experiments identified 6-hydroxykynurenic acid (6-HKA) as a major contributor to this effect of extract of G. biloba leaves (EGb) prepared according to the Chinese Pharmacopoeia (ChP). In order to elucidate the specific contribution of both proanthocyanidins and 6-HKA to the overall neurorestorative effects of this extract according to ChP, EGb ChP was separated into pure 6-HKA and a newly ...
Source: Planta Medica - May 15, 2020 Category: Drugs & Pharmacology Authors: Yao, Jianbiao Qiao, Hongxiang Jin, Zhuming Wang, Ruwei Huang, Haibo Fang, Ling Chen, Yan Tai, Khalid Chen, Yan Doeppner, Thorsten Roland Chen, Zhong Kuchta, Kenny Tags: Original Papers Source Type: research

Biochanin A, the Most Potent of 16 Isoflavones, Induces Relaxation of the Coronary Artery Through the Calcium Channel and cGMP-dependent Pathway
Planta Med DOI: 10.1055/a-1158-9422The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual pure isoflavonoids are mostly missing. For this study, 16 isoflavonoids were initially screened for their vasorelaxant properties on rat aortas. The 2 most potent of them, biochanin A and glycitein, were further tested for the mechanism of action on porcine coronary arteries...
Source: Planta Medica - May 14, 2020 Category: Drugs & Pharmacology Authors: Migkos, Thomas Pourov á, Jana Vopr šalová, Marie Auger, Cyril Schini-Kerth, Val érie Mlad ěnka, Přemysl Tags: Original Papers Source Type: research

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea
Planta Med DOI: 10.1055/a-1157-1732Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines should receive high priority. Plant-derived natural products are promising candidates for this purpose. We therefore screened alkaloid extracts obtained from the root and stem barks of the Mexican Apocynaceae species Tabernaemontana alba and Tabernaemontana arborea, as well as the...
Source: Planta Medica - May 11, 2020 Category: Drugs & Pharmacology Authors: Guzm án-Gutiérrez, Silvia Laura Silva-Miranda, Mayra Krengel, Felix Huerta-Salazar, Elizabeth Le ón-Santiago, Mayra D íaz-Cantón, Jessica Karina Espitia, Clara Reyes-Chilpa, Ricardo Tags: Original Papers Source Type: research

Erratum: Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception
Planta Med DOI: 10.1055/a-1170-9487 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 8, 2020 Category: Drugs & Pharmacology Authors: Ayumi, Rasyidah Ryta Shaik Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, Muhammad Taher Kamarudin, Nadhirah Hisamuddin, Nadia Talib, Madihah Sabar, Aina Mardhiah Tags: Erratum Source Type: research

Essential Oils as a Potential Treatment Option for Pediculosis
In this study, we focus on the essential oils derived from 22 plant genera, their constituents, and the major factors that play important roles in the effectiveness of these oils in the treatment of pediculosis. Furthermore, we discuss the advantages and limitations of the mentioned essential oils, and ultimately suggest those demonstrating the most effective in vitro pediculicidal activities. The genera such as Aloysia, Cinnamomum, Eucalyptus, Eugenia, Lavandula, Melaleuca, Mentha, Myrcianthes, Origanum, Pimpinella, and Thymus appear to be more efficient against lice. These genera are rich in anethole, 1,8-cineole, c...
Source: Planta Medica - May 4, 2020 Category: Drugs & Pharmacology Authors: Candy, Kerdalidec Akhoundi, Mohammad Andriantsoanirina, Val érie Durand, R émy Bruel, Christiane Izri, Arezki Tags: Reviews Source Type: research

Protective Effects of Total Alkaloids from Menispermum dauricum against Airway Inflammation in Asthmatic Mice
Planta Med DOI: 10.1055/a-1151-5138 Menispermum dauricum is widely used to treat respiratory inflammation, including laryngopharyngitis, tonsillitis, tracheitis, and bronchitis. Total alkaloids isolated from M. dauricum have shown a variety of beneficial bioactivities. However, available data on the effects of M. dauricum total alkaloids against allergic asthma has not been reported. In present study, the protective effect of M. dauricum total alkaloids was evaluated by using an ovalbumin-induced in vivo model of asthma. The asthma model was prepared by sensitizing and challenging mice with ovalbumin, and...
Source: Planta Medica - May 4, 2020 Category: Drugs & Pharmacology Authors: Lv, Le Yin, Bing You, Ye Sun, Zhongyang He, Jiao Cao, Yan Jun Tags: Original Papers Source Type: research

In Vitro and In Vivo Metabolic Activation of Obacunone, A Bioactive and Potentially Hepatotoxic Constituent of Dictamni Cortex
In this study, bioactivation pathways of obacunone in rat and human liver microsomes were investigated. Obacunone was first metabolized into cis-butene-1,4-dial, and then cis-butene-1,4-dial was captured by glutathione, N-acetyl-cysteine, and N-acetyl-lysine in the microsomal incubation system. A total of 13 adducts derived from the reaction of cis-butene-1,4-dial with glutathione and/or N-acetyl-lysine were detected and structurally identified by liquid chromatography coupled to high-resolution tandem mass spectrometry. The major metabolite (M7) was identified to be the cyclic mono-glutathione conjugate of cis-butene-1,4-...
Source: Planta Medica - May 4, 2020 Category: Drugs & Pharmacology Authors: Lang, Xiuzhuang Zhang, Xiangmei Wang, Daoquan Zhou, Weiqing Tags: Original Papers Source Type: research

Composition and Antibacterial Effect of Mint Flavorings in Candies and Food Supplements
Planta Med DOI: 10.1055/a-1158-1699Mint flavorings are widely used in confections, beverages, and dairy products. For the first time, mint flavoring composition of mint candies and food supplements (n = 45), originating from 16 countries, as well as their antibacterial properties, was analyzed. The flavorings were isolated by Marcussonʼs type micro-apparatus and analyzed by GC-MS. The total content of the mint flavoring hydrodistilled extracts was in the range of 0.01 – 0.9%. The most abundant compounds identified in the extracts were limonene, 1,8-cineole, menthone, menthofuran, isomenthone, menth...
Source: Planta Medica - May 4, 2020 Category: Drugs & Pharmacology Authors: Kapp, Karmen Orav, Anne Roasto, Mati Raal, Ain P üssa, Tõnu Vuorela, Heikki Tammela, P äivi Vuorela, Pia Tags: Original Papers Source Type: research

Investigation of Antiplasmodial Effects of Terpenoid Compounds Isolated from Myrrh
Planta Med DOI: 10.1055/a-1157-9463As part of our ongoing search for antiprotozoal natural products from plants, we examined different resins from the Burseraceae family. The dichloromethane extract obtained from myrrh, the oleo-gum-resin of Commiphora species, showed promising in vitro activity against Plasmodium falciparum with an IC50 value of 1 µg/mL. Bioactivity-guided fractionation led to the isolation and characterization of 18 sesquiterpenoids, namely, β-elemene (1), elemyl acetate (2), curzerenone (3), 8-hydroxyisogermafurenolide (4), 2-methoxyisogermafurenolide (5), 8-epi-2-methoxyisogermafureno...
Source: Planta Medica - May 4, 2020 Category: Drugs & Pharmacology Authors: Greve, Hippolyt L. Kaiser, Marcel Schmidt, Thomas J. Tags: Original Papers Source Type: research

Vasorelaxing Activity of Stilbenoid and Phenanthrene Derivatives from Brasiliorchis porphyrostele: Involvement of Smooth Muscle CaV1.2 Channels
Planta Med DOI: 10.1055/a-1154-8832Five compounds, 3,4′-dihydroxy-3′,5,5′-trimethoxydihydrostilbene, 1; 3,4′-ihydroxy-3′,5′-dimethoxydihydrostilbene, 2; 3,4′-dihydroxy-5,5′-dimethoxydihydrostilbene, 3; 9,10-dihydro-2,7-dihydroxy-4,6-dimethoxyphenanthrene, 4; and the previously unreported 1,2,6,7-tetrahydroxy-4-methoxyphenanthrene, 5 were isolated from the South American orchid, Brasiliorchis porphyrostele. An in-depth analysis of their vascular effects was performed on in vitro rat aorta rings and tail main artery myocytes. Compounds 1 – 4 were shown to possess vaso...
Source: Planta Medica - April 29, 2020 Category: Drugs & Pharmacology Authors: Waratchareeyakul, Watcharee Fusi, Fabio Durante, Miriam Ahmed, Amer Knirsch, Walter Mas-Claret, Eduard Mulholland, Dulcie A. Tags: Original Papers Source Type: research

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery
Planta Med DOI: 10.1055/a-1140-8388A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-i...
Source: Planta Medica - April 25, 2020 Category: Drugs & Pharmacology Authors: Pal, Pragya Paramita Shaik, Ameer Basha Begum, A. Sajeli Tags: Reviews Source Type: research

Anti-biofilm and Virulence Factor-Reducing Activities of Essential Oils and Oil Components as a Possible Option for Bacterial Infection Control
Planta Med DOI: 10.1055/a-1147-4671Pathogenic biofilm-associated bacteria that adhere to biological or nonbiological surfaces are a big challenge to the healthcare and food industries. Antibiotics or disinfectants often fail in an attempt to eliminate biofilms from those surfaces. Based on selected experimental research, this review deals with the potential biofilm-inhibiting, virulence factor-reducing, and biofilm-eradicating activities of essential oils and single essential oil compounds using Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Chromobacterium violaceum as model organisms. In addition, f...
Source: Planta Medica - April 23, 2020 Category: Drugs & Pharmacology Authors: Reichling, J ürgen Tags: Reviews Source Type: research

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents
Planta Med DOI: 10.1055/a-1148-9000Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for th...
Source: Planta Medica - April 23, 2020 Category: Drugs & Pharmacology Authors: Mamede, Lucia Ledoux, Allison Jansen, Olivia Fr édérich, Michel Tags: Reviews Source Type: research

Where Is Bacosine in Commercially Available Bacopa monnieri?
In this study, we have reinvestigated the contents of betulinic acid and bacosine, respectively, in extracts from various commercially available B. monnieri powders and food supplements. To our surprise, HPLC-ion trap time-of-flight analyses identified only betulinic acid, but not bacosine, in all extracts under study, which was verified by GC-MS, HPLC-ELSD, 1D NMR (1H,13C), and 2D NMR (1H,1H COSY, 1H,13C HMBC, 1H,13C HSQC, 1H,1H NOESY) experiments. Moreover, it turned out that commercially available reference samples of bacosine were structurally identical with betulinic acid. [...] Georg Thieme Verlag KG Stuttgart &middo...
Source: Planta Medica - April 23, 2020 Category: Drugs & Pharmacology Authors: Ritter, Stefanie Urmann, Corinna Herzog, Rainer Glaser, Jan Bieringer, Sebastian Geisberger, Thomas Eisenreich, Wolfgang Riepl, Herbert Tags: Original Papers Source Type: research

Norway Spruce Balm: Phytochemical Composition and Ability to Enhance Re-epithelialization In Vitro
In this study, the balm was subjected to fractionated extraction and further purified employing flash chromatography, HPLC-PDA-ELSD, preparative and analytical TLC. Hydroxycinnamic acids (1–3), the lignan pinoresinol (4), four hydroxylated derivatives of dehydroabietic acid (DHAA) (5 – 8), and dehydroabietic acid (9) were isolated. Their structures were elucidated by LC-MS, 1D- and 2D-NMR. Four extracts, two commercially available resin acids–pimaric acid (10) and isopimaric acid (11)–and the isolated compounds were tested for increased re-epithelialization of cell-free areas in a human adult lo...
Source: Planta Medica - April 21, 2020 Category: Drugs & Pharmacology Authors: Goels, Thomas Eichenauer, Elisabeth Langeder, Julia Hoeller, Franziska Sykora, Christina Tahir, Ammar Urban, Ernst Heiss, Elke H. Saukel, Johannes Glasl, Sabine Tags: Original Papers Source Type: research

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus
Planta Med DOI: 10.1055/a-1146-8369 Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1 – 4) and 10 known meroterpenoids (5 – 14). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1 – 14 against α-glucosidase were evaluated using p-nitrophenyl-α-D-glucopyranoside, sucrose, or malto...
Source: Planta Medica - April 21, 2020 Category: Drugs & Pharmacology Authors: Chen, Baosong Han, Junjie Bao, Li Wang, Wenzhao Ma, Ke Liu, Hongwei Tags: Original Papers Source Type: research

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells
Planta Med DOI: 10.1055/a-1134-3378Isoliquiritigenin, a flavonoid extracted from licorice root, has been shown to be active against most cancer cells; however, its antitumor activity is limited by its poor water solubility. The aim of this study was to develop a stable isoliquiritigenin nanosuspension for enhanced solubility and to evaluate its in vitro cytostatic activity in A549 cells. The nanosuspension of isoliquiritigenin was prepared through wet media milling with HPC SSL (hydroxypropyl cellulose-SSL) and PVP K30 (polyinylpyrrolidone-K30) as stabilizers, and the samples were then characterized according to particle s...
Source: Planta Medica - April 15, 2020 Category: Drugs & Pharmacology Authors: Qiao, Fangxia Zhao, Yue Mai, Yaping Guo, Jueshuo Dong, Luning Zhang, Wannian Yang, Jianhong Tags: Original Papers Source Type: research

Network Pharmacological Screening of the Active Ingredients and Hypoglycemic Effect of Isodon rubescens in the Treatment of Diabetes
This study was firstly to study the relationship of “ingredient-target-pathway” and the pharmacological effects of Isodon rubescens for the treatment of diabetes. Based on a network pharmacology method, 138 active ingredients of Isodon rubescens were screened from the relative literatures, and their targets were confirmed by comparing these with the hypoglycemic targets in the DrugBank database. Results showed that Isodon rubescens contained 25 hypoglycemic ingredients, such as rabdoternin A, rabdoternin B, and epinodosinol. These ingredients could activate 6 hypoglycemic targets, including 3-hydroxy-3-methylgl...
Source: Planta Medica - April 15, 2020 Category: Drugs & Pharmacology Authors: Jintao, Xue Shasha, Yu Jincai, Wang Chunyan, Li Mengya, Yang Yongli, Shi Tags: Original Papers Source Type: research

Isolation, Characterization and Targeted Metabolic Evaluation of Endophytic Fungi Harbored in 14 Seed-Derived Hypericum Species
Planta Med DOI: 10.1055/a-1130-4703Medicinal plants of the genus Hypericum are rich sources of bioactive naphthodianthrones, which are unique in the plant kingdom, but quite common in fungal endophytes. Cultivable endophytic fungi were isolated from 14 different Hypericum spp. originating from seeds grown under in vitro conditions and further acclimated to outdoor conditions. Among 37 fungal isolates yielded from the aerial and underground plant organs, 25 were identified at the species level by the fungal barcode marker internal transcribed spacer rDNA and protein-coding gene region of tef1α. Ten of them were isolat...
Source: Planta Medica - April 15, 2020 Category: Drugs & Pharmacology Authors: Henzelyov á, Jana Antalov á, Michaela Nigutov á, Katarína Logoida, Mariia Schreiberov á, Andrea Kusari, Souvik Čellárová, Eva Tags: Original Papers Source Type: research

Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception
Planta Med DOI: 10.1055/a-1144-3663The antinociceptive property of Centella asiatica extracts is known but the analgesic activity of its bioactive constituent asiaticoside has not been reported. We evaluated the antinociceptive activity of orally (p. o.) administered asiaticoside (1, 3, 5, and 10 mg/kg) in mice using the 0.6% acetic acid-induced writhing test, the 2.5% formalin-induced paw licking test, and the hot plate test. The capsaicin- and glutamate-induced paw licking tests were employed to evaluate the involvement of the vanilloid and glutamatergic systems, respectively. Asiaticoside (3, 5, and 10 m...
Source: Planta Medica - April 15, 2020 Category: Drugs & Pharmacology Authors: Ayumi, Rasyidah Ryta Mossadeq, Wan Mastura Shaik Zakaria, Zainul Amiruddin Bakhtiar, Muhammad Taher Kamarudin, Nadhirah Hisamuddin, Nadia Talib, Madihah Sabar, Aina Mardhiah Tags: Original Papers Source Type: research

A Systematic Review of the Potential Effects of Nigella sativa on Rheumatoid Arthritis
Planta Med DOI: 10.1055/a-1143-8521Considering the different untoward effects of the drugs prescribed for the treatment of rheumatoid arthritis (RA), there has been an increasing interest in adjuvant therapies devoid of such unfavorable reactions. Although the beneficial effects of Nigella sativa (N. sativa) on RA have been established, it seems that its mechanisms of action have not still been reviewed. The present review is designed to evaluate the effects of N. sativa on RA systematically. We searched these electronic databases until April 2019: PubMed, Scopus, ISI Web of Science, Cochrane Library, Embase, Ovi...
Source: Planta Medica - April 9, 2020 Category: Drugs & Pharmacology Authors: Khabbazi, Alireza Javadivala, Zeinab Seyedsadjadi, Neda Malek Mahdavi, Aida Tags: Original Papers Source Type: research

Antiviral Potential of Spondias mombin L. Leaves Extract Against Herpes Simplex Virus Type-1 Replication Using In Vitro and In Silico Approaches
Planta Med DOI: 10.1055/a-1135-9066 Spondias mobin leaves have been traditionally used for treating cold sores. The study investigated the mechanism of antiherpes action of S. mombin extract, fractions, and geraniin. Different concentrations of samples were used to evaluate the in vitro antiherpes activity (anti-HSV-1) in virucidal, post-infection, attachment, and penetration assays. The mechanism of action of geraniin was investigated considering the glycoproteins gB and gD of HSV-1 surface as potential molecular targets. Molecular docking simulations were carried out for both in order to determine the possible binding...
Source: Planta Medica - April 4, 2020 Category: Drugs & Pharmacology Authors: Siqueira, Emerson M. da S. Lima, T ábata L. C. Boff, Laurita Lima, Sarah G. M. Louren ço, Estela M. G. Ferreira, Éder G. Barbosa, Euz ébio G. Machado, Paula R. L. Farias, Kl éber J. S. Ferreira, Leandro de S. Rocha, Hugo A. de O. Sim ões, Cláudia M Tags: Original Papers Source Type: research

Vasorelaxant and Antihypertensive Effects of Neferine in Rats: An In Vitro and In Vivo Study
Planta Med DOI: 10.1055/a-1123-7852The present study was performed to examine the antihypertensive effect of neferine in hypertensive rats and its relaxant mechanisms in isolated rat thoracic aorta. The antihypertensive effect was evaluated by tail-cuff methods on NG-nitro-L-arginine methyl ester (L-NAME) (40 mg/kg BW) 4-week hypertensive-induced hypertensive rats. The vasorelaxant effect and its mechanisms were studied by the organ bath technique in the thoracic aorta isolated from normotensive rats. The results indicated that the treatment of neferine (1 mg/kg and 10 mg/kg) markedly decreased the sys...
Source: Planta Medica - March 27, 2020 Category: Drugs & Pharmacology Authors: Wicha, Piyawadee Onsa-ard, Amnart Chaichompoo, Waraluck Suksamrarn, Apichart Tocharus, Chainarong Tags: Original Papers Source Type: research

Evaluation of the hepatotoxic potential of Tinospora crispa and its isolated borapetosides B, C and F in a murine model
Planta Med DOI: 10.1055/a-1127-7503The hepatotoxic potential of the methanolic extract of the stems of Tinospora crispa and of its furano-diterpenoid–borapetosides B, C, and F–was investigated in normal and health-compromised mice. Health-compromised condition was established by a single intraperitoneal injection of LPS (6 mg/kg). Two different sets of experiments were conducted to evaluate the hepatotoxic potential. A 21-day study where the mice were dosed with the extract of T. crispa (1 gm/kg b. wt./day) or standardized combination of borapetosides B, C and F (500 mg/kg b. wt.) with ...
Source: Planta Medica - March 26, 2020 Category: Drugs & Pharmacology Authors: Parveen, Abidah Maqbool, Mir Tahir Wang, Yan-Hong Ali, Zulfiqar Khan, Ikhlas A. Ashfaq, M. Khalid Tags: Original Papers Source Type: research