Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update
Publication date: Available online 13 December 2018Source: Pharmacological ResearchAuthor(s): Zhichao Zhou, Takayuki Matsumoto, Vera Jankowski, John Pernow, S. Jamal Mustafa, Dirk J. Duncker, Daphne MerkusAbstractUridine adenosine tetraphosphate (Up4A), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of Up4A on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas,...
Source: Pharmacological Research - December 14, 2018 Category: Drugs & Pharmacology Source Type: research

The critical role of microRNAs in stress response: therapeutic prospect and limitation
Publication date: Available online 13 December 2018Source: Pharmacological ResearchAuthor(s): Jie Du, Mingliang Li, Qiong Huang, Wanli Liu, Wen-qun Li, Yuan-jiang Li, Zhi-cheng GongAbstractStress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific rol...
Source: Pharmacological Research - December 14, 2018 Category: Drugs & Pharmacology Source Type: research

Alzheimer’s disease: understanding homeostasis deregulation to foster development of effective therapies
Publication date: Available online 13 December 2018Source: Pharmacological ResearchAuthor(s): Robert Nisticò, Stéphane Peineau (Source: Pharmacological Research)
Source: Pharmacological Research - December 14, 2018 Category: Drugs & Pharmacology Source Type: research

Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease
Publication date: Available online 12 December 2018Source: Pharmacological ResearchAuthor(s): Marco Gentili, Simona Ronchetti, Erika Ricci, Rosanna Di Paola, Enrico Gugliandolo, Salvatore Cuzzocrea, Oxana Bereshchenko, Graziella Migliorati, Carlo RiccardiAbstractCannabinoids are known to possess anti-inflammatory and immunomodulatory properties, but the mechanisms involved are not fully understood. CB2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. In order to study the effect of JTE907, a selective/inverse agonist of CB2 with anti...
Source: Pharmacological Research - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

Idebenone and T2D: A new insulin-sensitizing drug for personalized therapy
Publication date: Available online 12 December 2018Source: Pharmacological ResearchAuthor(s): Alice Dassano, Cristian Loretelli, Paolo Fiorina (Source: Pharmacological Research)
Source: Pharmacological Research - December 13, 2018 Category: Drugs & Pharmacology Source Type: research

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC)
Publication date: Available online 11 December 2018Source: Pharmacological ResearchAuthor(s): Débora Kristina Alves-Fernandes, Érica Aparecida de Oliveira, Fernanda Faião-Flores, Gretchen Alicea-Rebecca, Ashani T. Weeraratna, Keiran S.M. Smalley, Silvia Berlanga de Moraes Barros, Silvya Stuchi Maria-EnglerAbstractMelanoma accounts for only 4% of malignant neoplasms of the skin, but is considered the most serious because it is highly deadly. Mutations in the MAPK (Ras-Raf-MEK-ERK) pathway is closely linked to the lack of control of cell proliferation. Especially in melanoma, this pathway has become a ta...
Source: Pharmacological Research - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Research Update and Opportunity of Non-hormonal Male Contraception: Histone Demethylase KDM5B-Based Targeting
Publication date: Available online 11 December 2018Source: Pharmacological ResearchAuthor(s): Sarder Arifuzzaman, Md Saidur Rahman, Myung-Geol PangAbstractWith the continued increase in global human population, diverse contraception approaches have become increasingly essential, including non-hormonal male contraception. Non-hormonal approaches to contraception are very convenient; however, such options are limited because data regarding the identification and characterization of tissue/cell-specific targets and appropriate small molecule candidate contraceptives are lacking. Based on in-silico studies of genomics, transcr...
Source: Pharmacological Research - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

3D organ models—Revolution in pharmacological research?
Publication date: January 2019Source: Pharmacological Research, Volume 139Author(s): Marie Weinhart, Andreas Hocke, Stefan Hippenstiel, Jens Kurreck, Sarah HedtrichAbstract3D organ models have gained increasing attention as novel preclinical test systems and alternatives to animal testing. Over the years, many excellent in vitro tissue models have been developed. In parallel, microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house several organ models on a single device and interlink these within a human-like environment. In contrast to these advancements, the development of ...
Source: Pharmacological Research - December 12, 2018 Category: Drugs & Pharmacology Source Type: research

Targeting STATs in neuroinflammation: the Road Less Traveled!
Publication date: Available online 11 December 2018Source: Pharmacological ResearchAuthor(s): Seyed Mohammad Nabavi, Touqeer Ahmed, Maheen Nawaz, Kasi Pandima Devi, Devasahayam Jaya Balan, Valeria Pittalà, Sandro Argüelles-Castilla, Lara Testai, Haroon Khan, Antoni Sureda, Marcos Roberto de Oliveira, Rosa Anna Vacca, Suowen Xu, Bahman Yousefi, Valeria Curti, Maria Daglia, Eduardo Sobarzo-Sánchez, Rosanna Filosa, Seyed Fazel Nabavi, Maryam MajidiniaAbstractJAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. D...
Source: Pharmacological Research - December 11, 2018 Category: Drugs & Pharmacology Source Type: research

Characteristics of Lipid Profile and Effectiveness of Management of Dyslipidaemia In Patients With Acute Coronary Syndromes – Data from the TERCET Registry with 19,287 patients
Publication date: Available online 6 December 2018Source: Pharmacological ResearchAuthor(s): Krzysztof Dyrbus, Mariusz Gasior, Piotr Desperak, Jolanta Nowak, Tadeusz Osadnik, Maciej BanachAbstractDespite well-defined therapeutic low-density lipoprotein cholesterol (LDL-C) target in the highest-risk population, low percentage of patients is administered with intensive lipid-lowering therapy and achieves recommended levels. Therefore, based on the Hyperlipidaemia Therapy in tERtiary Cardiological cEnTer (TERCET) Registry data we investigated the characteristics of lipid profile and management of dyslipidemia in acute coronar...
Source: Pharmacological Research - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons
Publication date: Available online 6 December 2018Source: Pharmacological ResearchAuthor(s): Guo-Qing Wang, Bei Zhang, Xue-Mei He, Dai-Di Li, Jing-Shan Shi, Feng ZhangAbstractAstroglia serve as a critical role in metabolic and neurotrophic support to neurons. The loss of astroglia-derived neurotrophic effects could be a primary contributor to Parkinson’s disease (PD). Thus, understanding astroglia functions is an important strategy for enhancing neuronal survival. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in neuronal resistance to oxidative stress and glutamate-induced excitotoxicity. Balanc...
Source: Pharmacological Research - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

A fresh look at cortical Dopamine D2 receptor expressing neurons
Publication date: Available online 4 December 2018Source: Pharmacological ResearchAuthor(s): Clémentine Quintana, Jean-Martin BeaulieuAbstractThe dopamine D2 receptor (DRD2) remains the principal target of antipsychotic drugs used for the management of schizophrenia and other psychotic disorders. This receptor is highly expressed within the basal ganglia, more specifically the striatal caudate nucleus and the nucleus accumbens. The general functions, signaling and behavioral contributions of striatal DRD2 are well understood. However, the study of cortical DRD2 expression and functions has for the most part been res...
Source: Pharmacological Research - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Use of oral contraceptives and risk of ulcerative colitis – A systematic review and meta-analysis
This study provides evidence of an association between the use of oral contraceptives and the onset risk of UC. The study also shows that the risk for patients who stop using the oral contraceptives was decreased. These findings may be used as important reference for the use of oral contraceptives and the management of UC patients.Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells
Publication date: Available online 27 November 2018Source: Pharmacological ResearchAuthor(s): Fiona Augsburger, Csaba SzaboAbstractHydrogen sulfide (H2S), produced by various endogenous enzyme systems, serves various biological regulatory roles in mammalian cells in health and disease. Over recent years, a new concept emerged in the field of H2S biology, showing that various cancer cells upregulate their endogenous H2S production, and utilize this mediator in autocrine and paracrine manner to stimulate proliferation, bioenergetics and tumor angiogenesis. Initial work identified cystathionine-beta-synthase (CBS) in many tum...
Source: Pharmacological Research - December 2, 2018 Category: Drugs & Pharmacology Source Type: research

Fecal Microbiota Transplantation Alleviates Myocardial Damage in Myocarditis by Restoring the Microbiota Composition
Publication date: Available online 30 November 2018Source: Pharmacological ResearchAuthor(s): Xiao-Fan Hu, Wen-Yong Zhang, Qiang Wen, Wei-Jun Chen, Zhi-Min Wang, Jian Chen, Feng Zhu, Kun Liu, Long-Xian Cheng, Jun Yang, Yan-Wen ShuAbstractMyocarditis can be caused by several infectious and noninfectious causes. Treatment for myocarditis is still a difficult task in clinical practice. The gut microbiota is related to cardiovascular diseases such as atherosclerosis and hypertension. However, little is known about the role of the gut microbiota in myocarditis. In our study, we tested the hypothesis that gut dysbiosis is associ...
Source: Pharmacological Research - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs
Publication date: Available online 30 November 2018Source: Pharmacological ResearchAuthor(s): Robert RoskoskiAbstractCyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle. The concentrations of the CDKs are generally constant, but their activities are controlled by the oscillation of the cyclin levels during each cell cycle. Additional CDK family members play significant roles in a wide range of activities including gene transcription, metabolism, and neuronal function....
Source: Pharmacological Research - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis
Publication date: Available online 29 November 2018Source: Pharmacological ResearchAuthor(s): Lingli Zheng, Xu Han, Yupeng Hu, Xuerong Zhao, Lianhong Yin, Lina Xu, Yan Qi, Youwei Xu, Xu Han, Kexin Liu, Jinyong PengAbstractInflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increased cell viability, and inhibited inflammation and apoptosis caused by hypoxia-reoxygenati...
Source: Pharmacological Research - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ
Publication date: Available online 29 November 2018Source: Pharmacological ResearchAuthor(s): Wai San Cheang, Wing Tak Wong, Li Wang, Chak Kwong Cheng, Chi Wai Lau, Ronald Chin Wan Ma, Aimin Xu, Nanping Wang, Yu Huang, Xiao Yu TianAbstractSirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes. However, whether SIRT1 also plays a protective role in vascular dysfunction of diabetic and obese mice is not fully characterized. Previous work showed that peroxisome proliferator-activated receptor δ (PPARδ)...
Source: Pharmacological Research - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

A nanodelivered Vorinostat derivative is a promising oral compound for the treatment of visceral leishmaniasis
Publication date: Available online 29 November 2018Source: Pharmacological ResearchAuthor(s): Victoriano Corpas-López, Mónica Díaz-Gavilán, Francisco Franco-Montalbán, Gemma Merino-Espinosa, Margarita López-Viota, Julián López-Viota, Efres Belmonte-Reche, José Pérez-del Palacio, Nuria de Pedro, José Antonio Gómez-Vidal, Francisco Morillas-Márquez, Joaquina Martín-SánchezAbstractThere is currently no satisfactory treatment for visceral leishmaniasis; the disease is thus in desperate need of novel drugs. The ideal candida...
Source: Pharmacological Research - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine
In conclusion, our results support the involvement of a PPARγ-mediated mechanism in the WSE effects on morphine-mediated nociception and the likely usefulness of WSE in lengthening the analgesic efficacy of opioids in chronic therapy.Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Use of oral contraceptives and risk of ulcerative colitis - a systematic review and meta-analysis
This study provides evidence of an association between the use of oral contraceptives and the onset risk of UC. The study also shows that the risk for patients who stop using the oral contraceptives was decreased. These findings may be used as important reference for the use of oral contraceptives and the management of UC patients.Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST) - hydrogen sulfide (H2S) pathway in cancer cells
Publication date: Available online 27 November 2018Source: Pharmacological ResearchAuthor(s): Fiona Augsburger, Csaba SzaboAbstractHydrogen sulfide (H2S), produced by various endogenous enzyme systems, serves various biological regulatory roles in mammalian cells in health and disease. Over recent years, a new concept emerged in the field of H2S biology, showing that various cancer cells upregulate their endogenous H2S production, and utilize this mediator in autocrine and paracrine manner to stimulate proliferation, bioenergetics and tumor angiogenesis. Initial work identified cystathionine-beta-synthase (CBS) in many tum...
Source: Pharmacological Research - November 28, 2018 Category: Drugs & Pharmacology Source Type: research

Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers
Publication date: Available online 27 November 2018Source: Pharmacological ResearchAuthor(s): Robert RoskoskiAbstractThe EGFR family is among the most investigated receptor protein-tyrosine kinase groups owing to its general role in signal transduction and in oncogenesis. This family consists of four members that belong to the ErbB lineage of proteins (ErbB1–4). The ErbB proteins function as homo and heterodimers. These receptors contain an extracellular domain that consists of four parts: domains I and III are leucine-rich segments that participate in growth factor binding (except for ErbB2) and domains II and IV co...
Source: Pharmacological Research - November 28, 2018 Category: Drugs & Pharmacology Source Type: research

Canrenone on cardiovascular mortality in congestive heart failure: Canrenone effects on cardiovascular mortality in patients with congestive heart failure: The coffee-IT study
ConclusionCanrenone administered to patients with CHF and preserved systolic fraction, reduced mortality and extended the life.Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - November 28, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: a systematic review meta-analysis
Publication date: Available online 28 November 2018Source: Pharmacological ResearchAuthor(s): Makan Pourmasoumi, Amir Hadi, Ameneh Najafgholizadeh, Marzieh Kafeshani, Amirhossein SahebkarAbstractCardiovascular disease is a one of most common causes of mortality around the world. This meta-analysis aims to summarize and conclude the clinical evidence regarding the use of saffron and its constituents, in particular crocin, on cardiovascular risk factors. A systematic review was conducted with PubMed, Scopus, Web of Science, Cochrane library and Google Scholar up to 24 May 2018. Randomized controlled trials (RCTs) that assess...
Source: Pharmacological Research - November 28, 2018 Category: Drugs & Pharmacology Source Type: research

Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Meihong Chen, Ke Ye, Biying Zhang, Qiao Xin, Ping Li, Ah-Ng Kong, Xiaodong Wen, Jie YangAbstractColorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Accumulating evidence suggests that mitochondrial dynamics are closely implicated in carcinogenesis including CRC. Paris Saponin II (PSII), a major steroidal saponin extracted from Rhizoma Paris polyphylla, has emerged as a potential anticancer agent. However, the effects of PSII on CRC and its underlying mechanisms remain unknown. ...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Understanding antidepressant tachyphylaxis
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Verinder Sharma (Source: Pharmacological Research)
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Role of MCP-1 and CCR2 in Alcohol Neurotoxicity
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Kai Zhang, Jia LuoAbstractAlcohol abuse causes profound damage to both the developing brain and the adult brain. Prenatal exposure to alcohol results in a wide range of deficits known as fetal alcohol spectrum disorders (FASD). Alcohol abuse in adults is associated with brain shrinkage, memory and attention deficits, communication disorders and physical disabilities. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate the recruitment and activation of monocytes and microglia. Both MCP-1 and i...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

The role of microbiota in the pathogenesis of lupus: Dose it impact lupus nephritis?
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Yalda Rahbar Saadat, Mina Hejazian, Milad Bastami, Seyed Mahdi Hosseinian Khatibi, Mohammadreza Ardalan, Sepideh Zununi VahedAbstractSystemic lupus erythematosus (SLE) is a complex, inflammatory, and autoimmune disease triggered by complicated interactions of different factors. A major contributor to morbidity and mortality in SLE is lupus nephritis (LN). To date, the cause of SLE and LN is incompletely understood but a combination of genetic and environmental factors is thought to be involved. In recent years, there have been att...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Beta-amyloid short- and long-term synaptic entanglement
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Cristina Lanni, Francesca Fagiani, Marco Racchi, Stefania Preda, Alessia Pascale, Massimo Grilli, Nicola Allegri, Stefano GovoniAbstractBeta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor protein (APP) by several secretases. Since its isolation and sequencing from Alzheimer’s disease (AD) brains, Aβ has been intensively investigated in the context of AD as the main pathogenic marker responsible for neurodegenerative processes. During the last three decades, results fro...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Reply to Dr. Sharma’ “Understanding antidepressant tachyphylaxis”
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Michele Fornaro (Source: Pharmacological Research)
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Young-Lai Cho, Jong-Gil Park, Hyo Jin Kang, Wooil Kim, Min Ji Cho, Ju-Hong Jang, Min-Gi Kwon, Sungsik Kim, Sang-Hyun Lee, Jangwook Lee, Yeon-Gu Kim, Young-Jun Park, Won Kon Kim, Kwang-Hee Bae, Byoung-Mog Kwon, Sang J. Chung, Jeong-Ki MinAbstractAdipogenesis involved in hypertrophy and hyperplasia of adipocytes is responsible for expanding the mass of adipose tissues in obese individuals. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are two principal tran...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry
Publication date: Available online 22 November 2018Source: Pharmacological ResearchAuthor(s): Dinesh C. Indurthi, Taima Qudah, Vivian W. Liao, Philip K. Ahring, Trevor M. Lewis, Thomas Balle, Mary Chebib, Nathan L AbsalomAbstractAutosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor. Pentameric α4β2 nACh receptors are the most abundant nicotinic receptor in the mammalian brain and form two stoichiometries, the (α4)3(&b...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model
In conclusion, bell-shaped curves in competitive binding experiments constitute evidence for GPCR homodimerization.Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Regulation of microglial process elongation, a featured characteristic of microglial plasticity
Publication date: Available online 23 November 2018Source: Pharmacological ResearchAuthor(s): Rongrong Yang, Hui Wang, Jie Wen, Kai Ma, Dongjian Chen, Zhuo Chen, Chao HuangAbstractMicroglia, a type of glia within the brain characterized by a ramified morphology, are essential for removing neuronal debris and restricting the expansion of a lesion site. Upon moderate activation, they undergo a transformation in morphology inducing beneficial responses. However, upon strong stimulation, they mediate neuronal damage via production of pro-inflammatory cytokines. The inhibition of this cascade is considered an effective strategy...
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: December 2018Source: Pharmacological Research, Volume 138Author(s): (Source: Pharmacological Research)
Source: Pharmacological Research - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Kadidia Diallo, Abel K. Oppong, Gareth E. LimAbstractSince their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into the cellular functions of 14-3-3 proteins has emerged. While one of the earliest functions attributed to this eukaryotic scaffold protein family was the activation of enzymes involved in catecholamine and serotonin biosynthesis, 14-3-3 proteins have since been implicated in the regulation of several cellular processes including cell-cycle control, apoptosis, and metabolism....
Source: Pharmacological Research - November 22, 2018 Category: Drugs & Pharmacology Source Type: research

How CaV1.2-bound verapamil blocks Ca2+ influx into cardiomyocyte: Atomic level views
Publication date: January 2019Source: Pharmacological Research, Volume 139Author(s): Wei Li, Ganggang ShiAbstractThe first clinically used antiarrhythmic, antianginal and anti-hypertensive phenylalkylamine, verapamil's cardiovascular activity is inextricably linked to its ability to antagonize Ca2+ overload via blocking CaV1.2, a cardiac L-type Ca2+ channel of undisputed physiological and pharmacological importance in cardiovascular disorders such as myocardial ischemia-reperfusion injury. From a structural point of view, however, the action mechanism of verapamil is still elusive. Therefore, incorporating previous finding...
Source: Pharmacological Research - November 22, 2018 Category: Drugs & Pharmacology Source Type: research

Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization
Publication date: Available online 20 November 2018Source: Pharmacological ResearchAuthor(s): Antonietta Rossi, Fiorentina Roviezzo, Rosalinda Sorrentino, Maria A. Riemma, Ida Cerqua, Rossella Bilancia, Giuseppe Spaziano, Fabiana Troisi, Simona Pace, Aldo Pinto, Bruno D’Agostino, Oliver Werz, Giuseppe CirinoAbstractThe incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during all...
Source: Pharmacological Research - November 21, 2018 Category: Drugs & Pharmacology Source Type: research

Synaptic Structural Protein Dysfunction Leads to Altered Excitation Inhibition Ratios in Models of Autism Spectrum Disorder
Publication date: Available online 19 November 2018Source: Pharmacological ResearchAuthor(s): Brian W. Howell, Kathleen M. SmithAbstractGenetics is believed to play a key role in the development of Autism Spectrum Disorder (ASD) and a plethora of potential candidate genes have been identified by genetic characterization of patients, their family members and controls. To make sense of this information investigators have searched for common pathways and downstream properties of neural networks that are regulated by these genes. For instance, several candidate genes encode synaptic proteins, and one hypothesis that has emerge...
Source: Pharmacological Research - November 19, 2018 Category: Drugs & Pharmacology Source Type: research

Prefrontal-Accumbens Opioid Plasticity: implications for relapse and dependence
Publication date: Available online 19 November 2018Source: Pharmacological ResearchAuthor(s): Matthew HearingABSTRACTIn addiction, an individual’s ability to inhibit drug seeking and drug taking is thought to reflect a pathological strengthening of drug-seeking behaviors or impairments in the capacity to control maladaptive behavior. These processes are not mutually exclusive and reflect drug-induced modifications within prefrontal cortical and nucleus accumbens circuits, however unlike psychostimulants such as cocaine, far less is known about the temporal, anatomical, and cellular dynamics of these changes. We discu...
Source: Pharmacological Research - November 19, 2018 Category: Drugs & Pharmacology Source Type: research

Prenatal therapeutics and programming of cardiovascular function
Publication date: Available online 17 November 2018Source: Pharmacological ResearchAuthor(s): Lesley Brennan, Styliani Goulopoulou, Stephane L. BourqueAbstractCardiovascular diseases (CVD) are a leading cause of mortality worldwide. Despite recognizing the importance of risk factors in dictating CVD susceptibility and onset, patient treatment remains a challenging endeavor. Increasingly, the benefits of prevention and mitigation of risk factors earlier in life are being acknowledged. The developmental origins of health and disease posits that insults during specific periods of development can influence long-term health out...
Source: Pharmacological Research - November 18, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Jan Skoda, Karolina Borankova, Patric J. Jansson, Michael L.-H. Huang, Renata Veselska, Des R. RichardsonAbstractMitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. In addition, it has come to light that mitochondria are crucially involved in the regulation of stem cell identity, differentiation and fate....
Source: Pharmacological Research - November 17, 2018 Category: Drugs & Pharmacology Source Type: research

Can 14-3-3 proteins serve as therapeutic targets for treatment of metabolic diseases?
Publication date: Available online 16 November 2018Source: Pharmacological ResearchAuthor(s): Kadidia Diallo, Abel K. Oppong, Gareth E. LimAbstractSince their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into the cellular functions of 14-3-3 proteins has emerged. While one of the earliest functions attributed to this eukaryotic scaffold protein family was the activation of enzymes involved in catecholamine and serotonin biosynthesis, 14-3-3 proteins have since been implicated in the regulation of several cellular processes including cell-cycle control, apoptosis, and metabolism....
Source: Pharmacological Research - November 17, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of Vitamin D supplementation on oxidative stress parameters: a systematic review and meta-analysis of clinical trials
Publication date: Available online 15 November 2018Source: Pharmacological ResearchAuthor(s): Mahdi Sepidarkish, Farnaz Farsi, Maryam Akbari-Fakhrabadi, Nazli Namazi, Amir Almasi-Hashiani, Arezoo Maleki, Javad HeshmatiAbstractRecent studies have shown that vitamin D supplementation beneficially decreases oxidative stress (OS) parameters; however, there is no consensus on this subject. In this systematic review and meta-analysis we aimed to investigate the effect of vitamin D supplementation on OS parameters. We searched electronic databases including Medline, Embase, Scopus, Web of Science and Cochrane Library up to July 2...
Source: Pharmacological Research - November 16, 2018 Category: Drugs & Pharmacology Source Type: research

How CaV1.2-Bound Verapamil Blocks Ca2+  Influx into Cardiomyocyte: Atomic Level Views
Publication date: Available online 14 November 2018Source: Pharmacological ResearchAuthor(s): Wei Li, Ganggang ShiAbstractThe first clinically used antiarrhythmic, antianginal and anti-hypertensive phenylalkylamine, verapamil's cardiovascular activity is inextricably linked to its ability to antagonize Ca2+  overload via blocking CaV1.2, a cardiac L-Type Ca2+  channel of undisputed physiological and pharmacological importance in cardiovascular disorders such as myocardial ischemia-reperfusion injury. From a structural point of view, however, the action mechanism of verapamil is still elusive. Therefore, incorpora...
Source: Pharmacological Research - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential
Publication date: January 2019Source: Pharmacological Research, Volume 139Author(s): Xiaojun Feng, Yi Li, Yanan Wang, Lingli Li, Peter J. Little, Suo-wen Xu, Sheng LiuAbstractCardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and...
Source: Pharmacological Research - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Response to: Letter to the Editor “Some thoughts about the possibility of diet-derived exogenous small RNAs”
Publication date: Available online 12 November 2018Source: Pharmacological ResearchAuthor(s): Joao Tomé-Carneiro, Eduardo Iglesias-Gutierrez, Alberto Dávalos (Source: Pharmacological Research)
Source: Pharmacological Research - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

Prenatal Metformin Exposure or Organic Cation Transporter 3 Knock-Out Curbs Social Interaction Preference in Male Mice
Publication date: Available online 10 November 2018Source: Pharmacological ResearchAuthor(s): Valentina R. Garbarino, Taylor A. Santos, Anastassia R. Nelson, Wynne Q. Zhang, Corey M. Smolik, Martin A. Javors, Lynette C. Daws, Georgianna G. GouldAbstractPoorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects in offspring are unclear. In light of beneficial findings...
Source: Pharmacological Research - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Some thoughts about the possibility of diet-derived exogenous small RNAs
Publication date: Available online 10 November 2018Source: Pharmacological ResearchAuthor(s): Celia Ross (Source: Pharmacological Research)
Source: Pharmacological Research - November 11, 2018 Category: Drugs & Pharmacology Source Type: research