Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects
Drug Deliv. 2024 Dec;31(1):2337423. doi: 10.1080/10717544.2024.2337423. Epub 2024 Apr 8.ABSTRACTThe present study was designed to develop a self-micellizing solid dispersion (SMSD) containing Thymoquinone (TQM), a phytonutrient obtained from Nigella sativa seeds, aiming to improve its biopharmaceutical and nephroprotective functions. The apparent solubility of TQM in polymer solutions was used to choose an appropriate amphiphilic polymer that could be used to make an SMSD system. Based on the apparent solubility, Soluplus® was selected as an appropriate carrier, and mixing with TQM, SMSD-TQM with different loadings of TQM...
Source: Drug Delivery - April 9, 2024 Category: Drugs & Pharmacology Authors: Shimul Halder Sanjida Afrose Manik Chandra Shill Nahid Sharmin Patricia Prova Mollick Madhabi Lata Shuma Md Abdul Muhit S M Abdur Rahman Source Type: research
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects
Drug Deliv. 2024 Dec;31(1):2337423. doi: 10.1080/10717544.2024.2337423. Epub 2024 Apr 8.ABSTRACTThe present study was designed to develop a self-micellizing solid dispersion (SMSD) containing Thymoquinone (TQM), a phytonutrient obtained from Nigella sativa seeds, aiming to improve its biopharmaceutical and nephroprotective functions. The apparent solubility of TQM in polymer solutions was used to choose an appropriate amphiphilic polymer that could be used to make an SMSD system. Based on the apparent solubility, Soluplus® was selected as an appropriate carrier, and mixing with TQM, SMSD-TQM with different loadings of TQM...
Source: Drug Delivery - April 9, 2024 Category: Drugs & Pharmacology Authors: Shimul Halder Sanjida Afrose Manik Chandra Shill Nahid Sharmin Patricia Prova Mollick Madhabi Lata Shuma Md Abdul Muhit S M Abdur Rahman Source Type: research
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2
In conclusion, (ACGs + Rh2)-Lipo not only alleviated the toxicity of ACGs to the organism, but also enhanced their anti-tumor activity, which is expected to break through their bottleneck.PMID:38555735 | PMC:PMC10984232 | DOI:10.1080/10717544.2024.2324716 (Source: Drug Delivery)
Source: Drug Delivery - March 31, 2024 Category: Drugs & Pharmacology Authors: Hui Ao Huizhu Song Jing Li Xiangtao Wang Source Type: research
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2
In conclusion, (ACGs + Rh2)-Lipo not only alleviated the toxicity of ACGs to the organism, but also enhanced their anti-tumor activity, which is expected to break through their bottleneck.PMID:38555735 | DOI:10.1080/10717544.2024.2324716 (Source: Drug Delivery)
Source: Drug Delivery - March 31, 2024 Category: Drugs & Pharmacology Authors: Hui Ao Huizhu Song Jing Li Xiangtao Wang Source Type: research
Backflow reduction in local injection therapy with gelatin formulations
Drug Deliv. 2024 Dec;31(1):2329100. doi: 10.1080/10717544.2024.2329100. Epub 2024 Mar 22.ABSTRACTThe local injection of therapeutic drugs, including cells, oncolytic viruses and nucleic acids, into different organs is an administrative route used to achieve high drug exposure at the site of action. However, after local injection, material backflow and side effect reactions can occur. Hence, this study was carried out to investigate the effect of gelatin on backflow reduction in local injection. Gelatin particles (GPs) and hydrolyzed gelatin (HG) were injected into tissue models, including versatile training tissue (VTT), v...
Source: Drug Delivery - March 22, 2024 Category: Drugs & Pharmacology Authors: Kazuki Kotani Francois Marie Ngako Kadji Yoshinobu Mandai Yosuke Hiraoka Source Type: research
