Resveratrol-Based Liposomes Improve Cardiac Remodeling Induced by Isoproterenol Partially by Modulating MEF2, Cytochrome C and S100A1 Expression
This study aims to investigate the molecular mechanisms underlying ISO-induced cardiac remodeling, the protective efficacy of resveratrol (RSVR), and its liposomal formulation (L-RSVR) against such cardiac change. Wistar albino rats were evenly divided into 4 groups. Control group, ISO group received ISO (50 mg/kg, s.c.) twice a week for 2 weeks, and RSVR- and L-RSVR-treated groups in which rats received either RSVR or L-RSVR (20 mg/kg/day, p.o.) along with ISO for 2 weeks. ISO caused a significant elevation of the expression levels of BAX and MEF2 mRNA, S100A1 and cytochrome C proteins, as well as DNA fragmentation in car...
Source: Dose Response - April 22, 2024 Category: Drugs & Pharmacology Authors: Ahlam M Alhusaini Hanan K Alghibiwi Wedad S Sarawi Juman S Alsaab Samiyah M Alshehri Qamraa H Alqahtani Aliah R Alshanwani Ebtesam A Aljassas Ebtesam N Alsultan Iman H Hasan Source Type: research
The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and/or Adenoidectomy: A Retrospective Dose-response Trial
Dose Response. 2024 Apr 19;22(2):15593258241248919. doi: 10.1177/15593258241248919. eCollection 2024 Apr-Jun.ABSTRACTThe incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5 μg·kg-1·h-1. The Pediatric Anesthesia Emergence Delirium ...
Source: Dose Response - April 22, 2024 Category: Drugs & Pharmacology Authors: BaiYun Wei CuiYu Yu JinBo Xiao Huang Xu Ping Zheng WeiBing Wang Source Type: research
Resveratrol-Based Liposomes Improve Cardiac Remodeling Induced by Isoproterenol Partially by Modulating MEF2, Cytochrome C and S100A1 Expression
This study aims to investigate the molecular mechanisms underlying ISO-induced cardiac remodeling, the protective efficacy of resveratrol (RSVR), and its liposomal formulation (L-RSVR) against such cardiac change. Wistar albino rats were evenly divided into 4 groups. Control group, ISO group received ISO (50 mg/kg, s.c.) twice a week for 2 weeks, and RSVR- and L-RSVR-treated groups in which rats received either RSVR or L-RSVR (20 mg/kg/day, p.o.) along with ISO for 2 weeks. ISO caused a significant elevation of the expression levels of BAX and MEF2 mRNA, S100A1 and cytochrome C proteins, as well as DNA fragmentation in car...
Source: Dose Response - April 22, 2024 Category: Drugs & Pharmacology Authors: Ahlam M Alhusaini Hanan K Alghibiwi Wedad S Sarawi Juman S Alsaab Samiyah M Alshehri Qamraa H Alqahtani Aliah R Alshanwani Ebtesam A Aljassas Ebtesam N Alsultan Iman H Hasan Source Type: research
The Median Effective Dose of Dexmedetomidine for the Inhibition of Emergence Delirium in Preschool Children Undergoing Tonsillectomy and/or Adenoidectomy: A Retrospective Dose-response Trial
Dose Response. 2024 Apr 19;22(2):15593258241248919. doi: 10.1177/15593258241248919. eCollection 2024 Apr-Jun.ABSTRACTThe incidence of emergence delirium (ED) is higher in preschool children undergoing tonsillectomy and/or adenoidectomy. The purpose of this study was to determine the median effective dose (ED50) of dexmedetomidine (DEX) for the inhibition of ED in preschool children by using probit regression analysis. A total of 140 anesthesia records were retrieved and divided into seven groups based on the infusion rate of DEX: .2, .25, .3, .35, .4, .45, and .5 μg·kg-1·h-1. The Pediatric Anesthesia Emergence Delirium ...
Source: Dose Response - April 22, 2024 Category: Drugs & Pharmacology Authors: BaiYun Wei CuiYu Yu JinBo Xiao Huang Xu Ping Zheng WeiBing Wang Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Enhancement of the Tumor Suppression Effect of High-dose Radiation by Low-dose Pre-radiation Through Inhibition of DNA Damage Repair and Increased Pyroptosis
Dose Response. 2024 Apr 11;22(2):15593258241245804. doi: 10.1177/15593258241245804. eCollection 2024 Apr-Jun.ABSTRACTRadiation therapy has been a critical and effective treatment for cancer. However, not all cells are destroyed by radiation due to the presence of tumor cell radioresistance. In the current study, we investigated the effect of low-dose radiation (LDR) on the tumor suppressive effect of high-dose radiation (HDR) and its mechanism from the perspective of tumor cell death mode and DNA damage repair, aiming to provide a foundation for improving the efficacy of clinical tumor radiotherapy. We found that LDR pre-i...
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Xinfeng Wei Junxuan Yi Citong Zhang Mingwei Wang Rui Wang Weiqiang Xu Mingqi Zhao Mengdie Zhao Teng Yang Wei Wei Shunzi Jin Hui Gao Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Probing Effect of 6 MeV Electron Beam Irradiation on Haemoglobin Protein Using Spectroscopic Techniques
Dose Response. 2024 Apr 1;22(2):15593258241240233. doi: 10.1177/15593258241240233. eCollection 2024 Apr-Jun.ABSTRACTIn this work, we study the effect of 6 MeV electron beam irradiation on the physicochemical properties of lyophilized Human Haemoglobin A (HbA). Electron beams generated from Race Track Microtron accelerator with energy 6 MeV were used to irradiate HbA at fluences of 5 × 1014 e-/cm2 and 10 × 1014 e-/cm2. Pristine and electron beam irradiated HbA were characterized using UV-visible and Fourier transform infrared spectroscopy (FTIR) spectroscopy. The interfacial tension of the aqueous solutions of HbA are als...
Source: Dose Response - April 5, 2024 Category: Drugs & Pharmacology Authors: Sarika Hinge Sanjay Dhole Arun Banpurkar Gauri Kulkarni Source Type: research
Probing Effect of 6 MeV Electron Beam Irradiation on Haemoglobin Protein Using Spectroscopic Techniques
Dose Response. 2024 Apr 1;22(2):15593258241240233. doi: 10.1177/15593258241240233. eCollection 2024 Apr-Jun.ABSTRACTIn this work, we study the effect of 6 MeV electron beam irradiation on the physicochemical properties of lyophilized Human Haemoglobin A (HbA). Electron beams generated from Race Track Microtron accelerator with energy 6 MeV were used to irradiate HbA at fluences of 5 × 1014 e-/cm2 and 10 × 1014 e-/cm2. Pristine and electron beam irradiated HbA were characterized using UV-visible and Fourier transform infrared spectroscopy (FTIR) spectroscopy. The interfacial tension of the aqueous solutions of HbA are als...
Source: Dose Response - April 5, 2024 Category: Drugs & Pharmacology Authors: Sarika Hinge Sanjay Dhole Arun Banpurkar Gauri Kulkarni Source Type: research
Probing Effect of 6 MeV Electron Beam Irradiation on Haemoglobin Protein Using Spectroscopic Techniques
Dose Response. 2024 Apr 1;22(2):15593258241240233. doi: 10.1177/15593258241240233. eCollection 2024 Apr-Jun.ABSTRACTIn this work, we study the effect of 6 MeV electron beam irradiation on the physicochemical properties of lyophilized Human Haemoglobin A (HbA). Electron beams generated from Race Track Microtron accelerator with energy 6 MeV were used to irradiate HbA at fluences of 5 × 1014 e-/cm2 and 10 × 1014 e-/cm2. Pristine and electron beam irradiated HbA were characterized using UV-visible and Fourier transform infrared spectroscopy (FTIR) spectroscopy. The interfacial tension of the aqueous solutions of HbA are als...
Source: Dose Response - April 5, 2024 Category: Drugs & Pharmacology Authors: Sarika Hinge Sanjay Dhole Arun Banpurkar Gauri Kulkarni Source Type: research
