Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Pharmacological Activities and In-Silico Studies of Bioactive Compounds Identified in Organic Fractions of the Methanolic Extract of < em > Citrullus Colocynthis < /em >
In this study, phytoconstituents in organic fractions (n-hexane, chloroform, and ethyl acetate) of the methanolic extract of C. colocynthis were analyzed and identified by FT-IR, HPLC, and GC-MS analysis. Ethyl acetate fraction showed the highest antioxidant scavenging (76 ± .769%) and anti-inflammatory (40 ± .473%) activities at the concentration of 3 mg/mL. Similarly, antidiabetic effect was measured by inhibition of α-amylase where, ethyl acetate fraction (77 ± .844%) exhibited the highest antidiabetic activity. Among all organic fractions, ethyl acetate exhibited strong antimicrobial potential followed by n-hexane ...
Source: Dose Response - July 12, 2023 Category: Drugs & Pharmacology Authors: Haseeb Akram Sindhu Muhammad Afzal Izzah Shahid Source Type: research
Radioactive < sup > 125 < /sup > I Seed Inhibits Cell Migration and Invasion and Promotes Apoptosis by Inactivating the VEGFR2 Signaling Pathway in Cholangiocarcinoma
CONCLUSION: 125I seed irradiation could inhibit cholangiocarcinoma cells proliferation, migration, and invasion and promote apoptosis through inactivation of the VEGFR2/PI3K/AKT signaling pathway.PMID:37424703 | PMC:PMC10328048 | DOI:10.1177/15593258231187348 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Authors: Jun Luo Jiaping Zheng Hongxiang Yao Binbing Wang Zhewei Zhang Guoliang Shao Source Type: research
RETRACTION NOTICE: Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels after Focal Cerebral Ischemia in Rats
Dose Response. 2023 Jun 29;21(2):15593258231185186. doi: 10.1177/15593258231185186. eCollection 2023 Apr-Jun.ABSTRACT[This retracts the article DOI: 10.1177/1559325819901242.].PMID:37425394 | PMC:PMC10328021 | DOI:10.1177/15593258231185186 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse
CONCLUSION: Our research determined the X-ray-specific sensitive gene set in mice lungs after exposure to radiation. The gene set could be used as a genetic marker to suggest the latency of RILI. The enrichment analysis results suggested that the relevant signaling pathways were potentially involved in the development of RILI. Further validation of those genes and signaling pathways is needed to confirm these findings.PMID:37425395 | PMC:PMC10328036 | DOI:10.1177/15593258231178146 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Authors: Tongtong Zhang Zhaoming Zhou Lei Wen Changguo Shan Mingyao Lai Jing Liao Xin Zeng Gang Yan Linbo Cai Meijuan Zhou Minghua Wang Source Type: research
Radioactive < sup > 125 < /sup > I Seed Inhibits Cell Migration and Invasion and Promotes Apoptosis by Inactivating the VEGFR2 Signaling Pathway in Cholangiocarcinoma
CONCLUSION: 125I seed irradiation could inhibit cholangiocarcinoma cells proliferation, migration, and invasion and promote apoptosis through inactivation of the VEGFR2/PI3K/AKT signaling pathway.PMID:37424703 | PMC:PMC10328048 | DOI:10.1177/15593258231187348 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Authors: Jun Luo Jiaping Zheng Hongxiang Yao Binbing Wang Zhewei Zhang Guoliang Shao Source Type: research
RETRACTION NOTICE: Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels after Focal Cerebral Ischemia in Rats
Dose Response. 2023 Jun 29;21(2):15593258231185186. doi: 10.1177/15593258231185186. eCollection 2023 Apr-Jun.ABSTRACT[This retracts the article DOI: 10.1177/1559325819901242.].PMID:37425394 | PMC:PMC10328021 | DOI:10.1177/15593258231185186 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse
CONCLUSION: Our research determined the X-ray-specific sensitive gene set in mice lungs after exposure to radiation. The gene set could be used as a genetic marker to suggest the latency of RILI. The enrichment analysis results suggested that the relevant signaling pathways were potentially involved in the development of RILI. Further validation of those genes and signaling pathways is needed to confirm these findings.PMID:37425395 | PMC:PMC10328036 | DOI:10.1177/15593258231178146 (Source: Dose Response)
Source: Dose Response - July 10, 2023 Category: Drugs & Pharmacology Authors: Tongtong Zhang Zhaoming Zhou Lei Wen Changguo Shan Mingyao Lai Jing Liao Xin Zeng Gang Yan Linbo Cai Meijuan Zhou Minghua Wang Source Type: research
Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study
Dose Response. 2023 Jun 21;21(2):15593258231185461. doi: 10.1177/15593258231185461. eCollection 2023 Apr-Jun.ABSTRACTDuring radiotherapy, immune-modulatory effects of radiation doses should be taken into consideration, not only the anti-tumor radiation effects. Thus, our study aimed to study how γ-radiation modulates immune response in comparison to common immune-suppressive/stimulant agents. Animals were divided into two groups. Category A received Echinacea purpura extract (EP) or irradiated at low radiation doses 0, .25 or .5 Gray (Gy), whereas Category B received cyclophosphamide (CP) or irradiated at high radiation d...
Source: Dose Response - June 26, 2023 Category: Drugs & Pharmacology Authors: Soha M Hussien Engy R Rashed Source Type: research
Antioxidant Potential and Improvement Activities of < em > Sterculia setigera < /em > Delile on Insulin Resistance in Type 2 Diabetic Rats Induced by High-Fat Diet and Low Dose of Streptozotocin
CONCLUSION: S. setigera extract could thus reverse insulin resistance and oxidative stress in type 2 diabetic rats induced.PMID:37359127 | PMC:PMC10286204 | DOI:10.1177/15593258231185460 (Source: Dose Response)
Source: Dose Response - June 26, 2023 Category: Drugs & Pharmacology Authors: Zacharie Tchoubou Beno ît Bargui Koubala Dieudonn é Ndjonka Source Type: research
