< em > Olea europaea L. < /em > Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis
In this study, we aim to investigate the effect of industrial Olea europaea L. leaf extract (OLE) against bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats. Male Wistar rats were treated with a single intratracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of OLE (10, 20, and 40 mg/kg) for 4 weeks. Results of HPLC and LC-MS analysis revealed a large amount of oleuropein (15.43%/DW) in OLE. BLM induced apparent damage of lung architecture with condensed collagen bundles, increased lipid peroxidation which has been deduced from malondialdehyde (MDA) levels: (.9 ± .13 vs .25 ± .12 nmol/mg protei...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Sana Bahri Anouar Abidi Afef Nahdi Raed Abdennabi Mona Mlika Ridha Ben Ali Saloua Jameleddine Source Type: research
Valorization of Baker Yeast Industry Waste in Agriculture by Improving Germination and Growth of Barley and Pea
Dose Response. 2023 Aug 30;21(3):15593258231198974. doi: 10.1177/15593258231198974. eCollection 2023 Jul-Sep.ABSTRACTIndustrial waste still present an environmental danger for the nature and survival of all living beings. Among these toxic products, the focus has been on liquid effluents from the baker's yeast industry that cause real environmental problems mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake of our environment, the present work consists on valorizing effluents from the baker's yeast industry on barley ...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Nadhem Aissani Rania Aissani Makrem Ghidaoui Ferjeni Zouidi Hichem Sebai Source Type: research
< em > Olea europaea L. < /em > Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis
In this study, we aim to investigate the effect of industrial Olea europaea L. leaf extract (OLE) against bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats. Male Wistar rats were treated with a single intratracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of OLE (10, 20, and 40 mg/kg) for 4 weeks. Results of HPLC and LC-MS analysis revealed a large amount of oleuropein (15.43%/DW) in OLE. BLM induced apparent damage of lung architecture with condensed collagen bundles, increased lipid peroxidation which has been deduced from malondialdehyde (MDA) levels: (.9 ± .13 vs .25 ± .12 nmol/mg protei...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Sana Bahri Anouar Abidi Afef Nahdi Raed Abdennabi Mona Mlika Ridha Ben Ali Saloua Jameleddine Source Type: research
Valorization of Baker Yeast Industry Waste in Agriculture by Improving Germination and Growth of Barley and Pea
Dose Response. 2023 Aug 30;21(3):15593258231198974. doi: 10.1177/15593258231198974. eCollection 2023 Jul-Sep.ABSTRACTIndustrial waste still present an environmental danger for the nature and survival of all living beings. Among these toxic products, the focus has been on liquid effluents from the baker's yeast industry that cause real environmental problems mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake of our environment, the present work consists on valorizing effluents from the baker's yeast industry on barley ...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Nadhem Aissani Rania Aissani Makrem Ghidaoui Ferjeni Zouidi Hichem Sebai Source Type: research
< em > Olea europaea L. < /em > Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis
In this study, we aim to investigate the effect of industrial Olea europaea L. leaf extract (OLE) against bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats. Male Wistar rats were treated with a single intratracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of OLE (10, 20, and 40 mg/kg) for 4 weeks. Results of HPLC and LC-MS analysis revealed a large amount of oleuropein (15.43%/DW) in OLE. BLM induced apparent damage of lung architecture with condensed collagen bundles, increased lipid peroxidation which has been deduced from malondialdehyde (MDA) levels: (.9 ± .13 vs .25 ± .12 nmol/mg protei...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Sana Bahri Anouar Abidi Afef Nahdi Raed Abdennabi Mona Mlika Ridha Ben Ali Saloua Jameleddine Source Type: research
Valorization of Baker Yeast Industry Waste in Agriculture by Improving Germination and Growth of Barley and Pea
Dose Response. 2023 Aug 30;21(3):15593258231198974. doi: 10.1177/15593258231198974. eCollection 2023 Jul-Sep.ABSTRACTIndustrial waste still present an environmental danger for the nature and survival of all living beings. Among these toxic products, the focus has been on liquid effluents from the baker's yeast industry that cause real environmental problems mainly due to their pollutant load and the release of unpleasant odors. In order to minimize these hazards and to take advantage of these wastes for the sake of our environment, the present work consists on valorizing effluents from the baker's yeast industry on barley ...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Nadhem Aissani Rania Aissani Makrem Ghidaoui Ferjeni Zouidi Hichem Sebai Source Type: research
< em > Olea europaea L. < /em > Leaf Extract Alleviates Fibrosis Progression and Oxidative Stress Induced by Bleomycin on a Murine Model of Lung Fibrosis
In this study, we aim to investigate the effect of industrial Olea europaea L. leaf extract (OLE) against bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats. Male Wistar rats were treated with a single intratracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of OLE (10, 20, and 40 mg/kg) for 4 weeks. Results of HPLC and LC-MS analysis revealed a large amount of oleuropein (15.43%/DW) in OLE. BLM induced apparent damage of lung architecture with condensed collagen bundles, increased lipid peroxidation which has been deduced from malondialdehyde (MDA) levels: (.9 ± .13 vs .25 ± .12 nmol/mg protei...
Source: Dose Response - September 5, 2023 Category: Drugs & Pharmacology Authors: Sana Bahri Anouar Abidi Afef Nahdi Raed Abdennabi Mona Mlika Ridha Ben Ali Saloua Jameleddine Source Type: research
Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway
This study intended to reveal this regulation and the underlying mechanisms. The U251, M059K, and SF-295 cell lines were treated with gradient concentrations of scutellarin and then IC50 was calculated. SF-295 cells selected for subsequent procedures were treated with four concentrations of scutellarin. Then, proliferation, apoptosis, and cell cycle, as well as the protein and mRNA expression of significantly differentially expressed genes identified by next-generation sequencing (NGS), were examined. The curative effect of scutellarin was validated by 5-FU as the positive control. Scutellarin inhibited proliferation and i...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Yongjie Chen Wenlan Li Source Type: research
Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line
Dose Response. 2023 Aug 24;21(3):15593258231185457. doi: 10.1177/15593258231185457. eCollection 2023 Jul-Sep.ABSTRACTNanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential. Herein, we examined the effects of CdTe-QD NPs on gene expression profile of hepatocellular carcinoma (Huh-7) ...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Hani Alothaid Mashael R Al-Anazi Arwa A Al-Qahtani Dilek Colak Azeez Yusuf Mohammed S Aldughaim Ali M Mahzari Mahmoud M Habibullah Saud Alarifi Saad Alkahtani Ahmed A Al-Qahtani Source Type: research
Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway
This study intended to reveal this regulation and the underlying mechanisms. The U251, M059K, and SF-295 cell lines were treated with gradient concentrations of scutellarin and then IC50 was calculated. SF-295 cells selected for subsequent procedures were treated with four concentrations of scutellarin. Then, proliferation, apoptosis, and cell cycle, as well as the protein and mRNA expression of significantly differentially expressed genes identified by next-generation sequencing (NGS), were examined. The curative effect of scutellarin was validated by 5-FU as the positive control. Scutellarin inhibited proliferation and i...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Yongjie Chen Wenlan Li Source Type: research
Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line
Dose Response. 2023 Aug 24;21(3):15593258231185457. doi: 10.1177/15593258231185457. eCollection 2023 Jul-Sep.ABSTRACTNanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential. Herein, we examined the effects of CdTe-QD NPs on gene expression profile of hepatocellular carcinoma (Huh-7) ...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Hani Alothaid Mashael R Al-Anazi Arwa A Al-Qahtani Dilek Colak Azeez Yusuf Mohammed S Aldughaim Ali M Mahzari Mahmoud M Habibullah Saud Alarifi Saad Alkahtani Ahmed A Al-Qahtani Source Type: research
Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway
This study intended to reveal this regulation and the underlying mechanisms. The U251, M059K, and SF-295 cell lines were treated with gradient concentrations of scutellarin and then IC50 was calculated. SF-295 cells selected for subsequent procedures were treated with four concentrations of scutellarin. Then, proliferation, apoptosis, and cell cycle, as well as the protein and mRNA expression of significantly differentially expressed genes identified by next-generation sequencing (NGS), were examined. The curative effect of scutellarin was validated by 5-FU as the positive control. Scutellarin inhibited proliferation and i...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Yongjie Chen Wenlan Li Source Type: research
Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line
Dose Response. 2023 Aug 24;21(3):15593258231185457. doi: 10.1177/15593258231185457. eCollection 2023 Jul-Sep.ABSTRACTNanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential. Herein, we examined the effects of CdTe-QD NPs on gene expression profile of hepatocellular carcinoma (Huh-7) ...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Hani Alothaid Mashael R Al-Anazi Arwa A Al-Qahtani Dilek Colak Azeez Yusuf Mohammed S Aldughaim Ali M Mahzari Mahmoud M Habibullah Saud Alarifi Saad Alkahtani Ahmed A Al-Qahtani Source Type: research
Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway
This study intended to reveal this regulation and the underlying mechanisms. The U251, M059K, and SF-295 cell lines were treated with gradient concentrations of scutellarin and then IC50 was calculated. SF-295 cells selected for subsequent procedures were treated with four concentrations of scutellarin. Then, proliferation, apoptosis, and cell cycle, as well as the protein and mRNA expression of significantly differentially expressed genes identified by next-generation sequencing (NGS), were examined. The curative effect of scutellarin was validated by 5-FU as the positive control. Scutellarin inhibited proliferation and i...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Yongjie Chen Wenlan Li Source Type: research
Exposure to Cadmium Telluride Quantum Dots and Gene Expression Profile of Huh-7 Hepatocellular Carcinoma Cell Line
Dose Response. 2023 Aug 24;21(3):15593258231185457. doi: 10.1177/15593258231185457. eCollection 2023 Jul-Sep.ABSTRACTNanoparticles have shown promising potential for efficient drug delivery, circumventing biological interferences like immunological and renal clearance and mechanical and enzymatic destruction. However, a handful of research papers have questioned the biomedical use of metal-based nanoparticles like cadmium telluride quantum dots (CdTe-QDs) for their cytotoxic, genotoxic, and carcinogenic potential. Herein, we examined the effects of CdTe-QD NPs on gene expression profile of hepatocellular carcinoma (Huh-7) ...
Source: Dose Response - September 1, 2023 Category: Drugs & Pharmacology Authors: Hani Alothaid Mashael R Al-Anazi Arwa A Al-Qahtani Dilek Colak Azeez Yusuf Mohammed S Aldughaim Ali M Mahzari Mahmoud M Habibullah Saud Alarifi Saad Alkahtani Ahmed A Al-Qahtani Source Type: research
