20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades
Publication date: Available online 15 May 2020Source: Journal of Ginseng ResearchAuthor(s): Sirui Zhu, Xiaoli Liu, Mei Xue, Yu Li, Danhong Cai, Shijun Wang, Liang Zhang (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 31, 2020 Category: Complementary Medicine Source Type: research

Bone remodeling effects of Korean Red ginseng extracts for dental implant applications
Publication date: Available online 27 May 2020Source: Journal of Ginseng ResearchAuthor(s): Myong-Hun Kang, Sook-Jeong Lee, Min-Ho Lee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 27, 2020 Category: Complementary Medicine Source Type: research

Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus
Publication date: Available online 18 May 2020Source: Journal of Ginseng ResearchAuthor(s): Pan-Pan Shu, Lu-Xi Li, Qin-Min He, Jun Pan, Xiao-Lei Li, Min Zhu, Ye Yang, Yuan Qu (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 19, 2020 Category: Complementary Medicine Source Type: research

20(S)-Ginsenoside Rh2 induces caspase-dependent PML-RARA degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades
Publication date: Available online 15 May 2020Source: Journal of Ginseng ResearchAuthor(s): Sirui Zhu, Xiaoli Liu, Mei Xue, Yu Li, Danhong Cai, Shijun Wang, Liang Zhang (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 16, 2020 Category: Complementary Medicine Source Type: research

Ginseng Gintonin Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis through LPA1 receptor
Publication date: Available online 1 May 2020Source: Journal of Ginseng ResearchAuthor(s): Sung Min Nam, Jong Hee Choi, Sun-Hye Choi, Hee-Jung Cho, Yeon-Jin Cho, Hyewhon Rhim, Hyoung-Chun Kim, Ik-Hyun Cho, Do-Geun Kim, Seung-Yeol Nah (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 1, 2020 Category: Complementary Medicine Source Type: research

Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells
Publication date: Available online 10 April 2020Source: Journal of Ginseng ResearchAuthor(s): Myung-Ho Kim, Hee-Hoon Kim, Jong-Min Jeong, Young-Ri Shim, Jun-Hee Lee, Ye Eun Kim, Tom Ryu, Keungmo Yang, Kyu-Rae Kim, Byeong-Min Jeon, Sun Chang Kim, Jae-Kwang Jung, Jae-Kap Choi, Young-Sun Lee, Jin-Seok Byun, Won-Il Jeong (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 28, 2020 Category: Complementary Medicine Source Type: research

Ginsenosides Rk1 and Rg5 inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in lung cancer
Publication date: Available online 3 April 2020Source: Journal of Ginseng ResearchAuthor(s): Hyunhee Kim, Pilju Choi, Taejung Kim, Youngseok Kim, Bong Geun Song, Young-Tae Park, Seon-Jun Choi, Cheol Hee Yoon, Won-Chul Lim, Hyeonseok Ko, Jungyeob Ham (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 22, 2020 Category: Complementary Medicine Source Type: research

Improvement of antithrombotic activity of red ginseng extract by nanoencapsulation using chitosan and antithrombotic cross-linkers: polyglutamic acid and fucodian
Publication date: Available online 10 April 2020Source: Journal of Ginseng ResearchAuthor(s): Eun Suh Kim, Ji-Soo Lee, Hyeon Gyu Lee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 12, 2020 Category: Complementary Medicine Source Type: research

Ginsenoside F2 attenuates chronic binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells
Publication date: Available online 10 April 2020Source: Journal of Ginseng ResearchAuthor(s): Myung-Ho Kim, Hee-Hoon Kim, Jong-Min Jeong, Young-Ri Shim, Jun-Hee Lee, Ye Eun Kim, Tom Ryu, Keungmo Yang, Kyu-Rae Kim, Byeong-Min Jeon, Sun Chang Kim, Jae-Kwang Jung, Jae-Kap Choi, Young-Sun Lee, Jin-Seok Byun, Won-Il Jeong (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 10, 2020 Category: Complementary Medicine Source Type: research

A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice
Publication date: Available online 21 March 2020Source: Journal of Ginseng ResearchAuthor(s): Evelyn Saba, Yuan Yee Lee, Minki Kim, Sun-Hee Hyun, Chae-Kyu Park, Eunjung Son, Dong-Seon Kim, Sung-Dae Kim, Man Hee Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 9, 2020 Category: Complementary Medicine Source Type: research

The frequency of defective genes in vif and vpr genes in 20 hemophiliacs is associated with Korean Red Ginseng and highly active antiretroviral therapy: The impact of lethal mutations in vif and vpr genes on HIV-1 evolution
Publication date: Available online 8 April 2020Source: Journal of Ginseng ResearchAuthor(s): Young Keol Cho, Jung-Eun Kim (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 9, 2020 Category: Complementary Medicine Source Type: research

Spatial Protein Expression of Panax Ginseng by In-depth Proteomic Analysis for Ginsenoside Biosynthesis and Transportation
Publication date: Available online 6 April 2020Source: Journal of Ginseng ResearchAuthor(s): Xiaoying Li, Xianhui Cheng, Baosheng Liao, Jiang Xu, Xu Han, Jinbo Zhang, Zhiwei Lin, Lianghai Hu (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 7, 2020 Category: Complementary Medicine Source Type: research

Ginsenosides Rk1 and Rg5 inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress migration, invasion, anoikis resistance, and development of stem-like features in lung cancer
Publication date: Available online 3 April 2020Source: Journal of Ginseng ResearchAuthor(s): Hyunhee Kim, Pilju Choi, Taejung Kim, Youngseok Kim, Bong Geun Song, Young-Tae Park, Seon-Jun Choi, Cheol Hee Yoon, Won-Chul Lim, Hyeonseok Ko, Jungyeob Ham (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 3, 2020 Category: Complementary Medicine Source Type: research

Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions
Publication date: Available online 28 March 2020Source: Journal of Ginseng ResearchAuthor(s): Muhammad Irfan, Yi-Seong Kwak, Chang-Kyun Han, Sun-Hee Hyun, Man Hee Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 30, 2020 Category: Complementary Medicine Source Type: research

Pharmacological potential of ginseng and its major component ginsenosides
Publication date: Available online 25 March 2020Source: Journal of Ginseng ResearchAuthor(s): Zubair Ahmed Ratan, Mohammad Faisal Haidere, Yo Han Hong, Sang Hee Park, Jeong-Oog Lee, Jongsung Lee, Jae Youl Cho (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 26, 2020 Category: Complementary Medicine Source Type: research

A novel herbal formulation consisting of Red ginseng extract and Epimedium Koreanum Nakai attenuated dextran sulfate sodium induced colitis in mice
Publication date: Available online 21 March 2020Source: Journal of Ginseng ResearchAuthor(s): Evelyn Saba, Yuan Yee Lee, Minki Kim, Sun-Hee Hyun, Chae-Kyu Park, Eunjung Son, Dong-Seon Kim, Sung-Dae Kim, Man Hee Rhee (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 22, 2020 Category: Complementary Medicine Source Type: research

Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan–calcium nanoparticles and its cytotoxic potential against prostate cancer cells
ConclusionGK–OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the antiproliferative effects of GK. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 22, 2020 Category: Complementary Medicine Source Type: research

The safety, immunological benefits, and efficacy of ginseng in organ transplantation
Publication date: Available online 7 February 2020Source: Journal of Ginseng ResearchAuthor(s): Sun Woo Lim, Kang Luo, Yi Quan, Sheng Cui, Yoo Jin Shin, Eun Jeong Ko, Byung Ha Chung, Chul Woo YangAbstractKorean ginseng (Panax ginseng) is associated with a variety of therapeutic effects, including antioxidative, anti-inflammatory, vasorelaxative, antiallergic, antidiabetic, and anticancer effects. Accordingly, the use of ginseng has reached an all-time high among members of the general public. However, the safety and efficacy of ginseng in transplant recipients receiving immunosuppressant drugs has not yet been elucidated. ...
Source: Journal of Ginseng Research - February 8, 2020 Category: Complementary Medicine Source Type: research

Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation
ConclusionOverall, our results suggest that G-Rb1 exerts cartilage protective effect on MIA-induced ovariectomized OA rats, by inhibiting inflammatory mediators such as IL-6, IL-1β, monocyte chemoattractant protein-1/CCL2, COX-2, and PGE2. These results shed a light on possible therapeutic application of G-Rb1 in OA. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2020 Category: Complementary Medicine Source Type: research

Comparative transcriptome analysis of the protective effects of Korean red ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice
ConclusionOur data suggest that BPA has commonly influenced inflammatory response effects on both normal and ovariectomized mice. KRG protects against BPA impact of inflammatory response and chemotaxis in ovariectomized mouse models. Our comparative analysis will provide new insight into the efficacy of KRG on endocrine disrupting chemicals (EDCs) and ovariectomized (OVX) mouse.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 7, 2020 Category: Complementary Medicine Source Type: research

Characterisation of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan-calcium nanoparticles and its cytotoxic potential against prostate cancer cells
ConclusionGK-OCMC Nps are potential nanocarriers for delivering hydrophobic drugs, thereby enhancing water solubility and permeability and improving the anti-proliferative effects of GK.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - February 6, 2020 Category: Complementary Medicine Source Type: research

Physiological and pharmacological features of the non-saponin components in Korean Red ginseng
Publication date: Available online 6 February 2020Source: Journal of Ginseng ResearchAuthor(s): Sun Hee Hyun, Sung Won Kim, Hwi Won Seo, Soo Hyun Youn, Jong Soo Kyung, Yong Yook Lee, In Gyo, Chae-Kyu Park, Chang-Kyun HanAbstractPanax ginseng, a medicinal plant, has been used as a blood-nourishing tonic for thousands of years in Asia, including Korea and China. P. ginseng exhibits adaptogen activity that maintains homeostasis by restoring general biological functions and non-specifically enhancing the body's resistance to external stress. Several P. ginseng effects have been reported. Korean Red ginseng, in particular, has ...
Source: Journal of Ginseng Research - February 6, 2020 Category: Complementary Medicine Source Type: research

Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment
ConclusionThus, the industrial preparation of less-polar ginsenosides from SNG is more efficient and cheaper. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 31, 2020 Category: Complementary Medicine Source Type: research

Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby, interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium (CM) obtained from IR- a...
Source: Journal of Ginseng Research - January 31, 2020 Category: Complementary Medicine Source Type: research

Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistance in Panax ginseng
ConclusionR. panacihumi DCY116T can be used as potential PGPR and “plant strengthener” for future cultivation of ginseng or other crops/plants that are grown in regions with heavy metal exposure. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 25, 2020 Category: Complementary Medicine Source Type: research

Ginsenoside-Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation
ConclusionOverall, our results suggest that G-Rb1 exerts cartilage protective effect on MIA induced ovariectomized OA rats, by inhibiting inflammatory mediators such as IL-6, IL-1β, MCP1/CCL2, COX-2, and PGE2. These results shed a light on possible therapeutic application of G-Rb1 in OA.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 21, 2020 Category: Complementary Medicine Source Type: research

Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
ConclusionThis is the first report on the synthesis of two novel ginsenosides, namely, glucosyl ginsenoside Rh2 and diglucosyl ginsenoside Rh2 from Rh2 by using recombinant GT isolated from L. rhamnosus. Moreover, diglucosyl ginsenoside Rh2 might be a new candidate for treatment of inflammation, obesity, and skin whiting, and especially for anticancer. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 19, 2020 Category: Complementary Medicine Source Type: research

Phytochemical analysis of Panax species: A review
Publication date: Available online 14 January 2020Source: Journal of Ginseng ResearchAuthor(s): Yuangui Yang, Zhengcai Ju, Yingbo Yang, Yanhai Zhang, Li Yang, Zhengtao WangAbstractPanax species obtain numerous attentions due to various biological effects on cardiovascular, kidney, reproductive disease for a long history. Recently, advanced analytical methods include thin layer chromatography, high performance thin layer chromatography, gas chromatography, high performance liquid chromatography, ultra-high performance liquid chromatography tandem with ultraviolet, diode array detector, evaporative light scattering detector ...
Source: Journal of Ginseng Research - January 15, 2020 Category: Complementary Medicine Source Type: research

Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of ROS
ConclusionsOverall, our results suggest that KRG exerts an anti-inflammatory effect on BPA-treated A549 cells via the suppression of ROS and down-regulation of NF-κB activation and COX-2 expression which leads to a decrease in cellular migration and MMP-9 expression. These results provide a new possible therapeutic application of KRG to protect BPA-induced possible inflammatory disorders.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 15, 2020 Category: Complementary Medicine Source Type: research

Stem-leaves of Panax as a Rich and Sustainable Source of Less Polar Ginsenosides: Comparison of Ginsenosides from Panax Ginseng, American Ginseng and Panax notoginseng Prepared by Heating & Acid Treatment
ConclusionThus, the industrial preparation of less polar ginsenosides from SNG is more efficient and cheaper.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 13, 2020 Category: Complementary Medicine Source Type: research

Influence of the plant growth promoting Rhizobium panacihumi on aluminum resistant in Panax ginseng
ConclusionR. panacihumi DCY116T can be used as a potential PGPR and “plant strengthener” for future cultivation of ginseng or other crops/plants that are grown in regions with heavy metal exposure.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 9, 2020 Category: Complementary Medicine Source Type: research

The non-saponin fraction of Korean red ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo
ConclusionOur study thereby demonstrated that KGC05P0 exerted anti-diabetic effects through inhibition of glucose absorption and the PI3K/AKT pathway in in vitro and in vivo models of diabetes. Our results suggest that KGC05P0 could be developed as a complementary food to help prevent T2DM and its complications. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer
ConclusionPQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research

Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer
ConclusionsIt was confirmed that SPR DCY119T can potentially be used for bioremediation of heavy metal contamination.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 7, 2020 Category: Complementary Medicine Source Type: research

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors
ConclusionsWe found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 1, 2020 Category: Complementary Medicine Source Type: research

Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation
Publication date: Available online 24 December 2019Source: Journal of Ginseng ResearchAuthor(s): Miyong Yun, Young-Su YiAbstractInflammation is an immune response that protects against pathogens and cellular stress. The hallmark of inflammatory responses is inflammasome activation in response to various stimuli. This subsequently activates downstream effectors, i.e., inflammatory caspases such as caspase-1, 4, 5, 11, and 12. Extensive efforts have been made on developing effective and safe anti-inflammatory therapeutics, and ginseng has long been traditionally utilized as efficacious and safe herbal medicine in treating va...
Source: Journal of Ginseng Research - December 24, 2019 Category: Complementary Medicine Source Type: research

Oral administration of hydrolyzed red ginseng extract improves learning and memory capability of scopolamine-treated C57BL/6J mice via upregulation of Nrf2-mediated antioxidant mechanism
ConclusionThese findings suggest that HRGE administration can effectively alleviate hippocampus-mediated cognitive impairment, possibly through cytoprotective mechanisms, preventing oxidative stress-induced neuronal cell death via the upregulation of phase 2 antioxidant molecules.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 21, 2019 Category: Complementary Medicine Source Type: research

Ginsenosides: potential therapeutic source for fibrosis-associated human diseases
In this report, our aim was to focus on the therapeutic prospects of ginsenosides in fibrosis-related human diseases making use of results acquired from various animal models. These findings should provide important therapeutic clues and strategies for the exploration of new drugs for fibrosis treatment.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research

The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo.
ConclusionOur study thereby demonstrated that KGC05P0 exerted anti-diabetic effects through inhibition of glucose absorption and the PI3K/AKT pathway in in vitro and in vivo models of diabetes. Our results suggest that KGC05P0 could be developed as a complementary food to help prevent T2DM and its complications. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer’s disease, through LPA1/3 and VEGF receptors
ConclusionsWe found that intravenous, but not oral, administration of gintonin facilitates brain delivery of donepezil from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of donepezil for treatment of the AD brain.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2019 Category: Complementary Medicine Source Type: research

Ginseng alleviates microbial infections of the respiratory tract: A review
Publication date: Available online 12 December 2019Source: Journal of Ginseng ResearchAuthor(s): Hamid Iqbal, Dong-kwon RheeAbstractThe detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especially against pathogens that cause respiratory infections in animal and in vitro models. Some of the possible mechanisms for ginseng-mediated viral inhibition may be improvements in sy...
Source: Journal of Ginseng Research - December 13, 2019 Category: Complementary Medicine Source Type: research

Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has antimelanogenic activities
ConclusionThis study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of P. ginseng, can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with P. ginseng for cosmetic ingredients. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 9, 2019 Category: Complementary Medicine Source Type: research

Gastroprotective effects of the nonsaponin fraction of Korean red ginseng through cyclooxygenase-1 upregulation
ConclusionThese results suggest that NSF has gastroprotective effects on gastritis and colitis in in vivo mouse models through COX-1 upregulation. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 6, 2019 Category: Complementary Medicine Source Type: research

Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stress–induced mitochondrial injury
ConclusionGP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 3, 2019 Category: Complementary Medicine Source Type: research

Effect of coadministration of enriched Korean red ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
ConclusionCoadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.Clinical trial registrationClinicaltrials.gov identifier, NCT01578837; (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 2, 2019 Category: Complementary Medicine Source Type: research

Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate  receptor modulation in mice
ConclusionThese results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 26, 2019 Category: Complementary Medicine Source Type: research

Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms
ConclusionResearch found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 26, 2019 Category: Complementary Medicine Source Type: research

Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has anti-melanogenic activities
ConclusionThis study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of P. ginseng, can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with P. ginseng for cosmetic ingredients.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 22, 2019 Category: Complementary Medicine Source Type: research

Gastroprotective effects of the non-saponin fraction of Korean red ginseng through COX-1 upregulation
ConclusionThese results suggest that NSF has gastroprotective effects on gastritis and colitis in in vivo mouse models through COX-1 upregulation.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 16, 2019 Category: Complementary Medicine Source Type: research

Effect of Co-administration of Enriched Korean Red Ginseng (Panax Ginseng) and American Ginseng (Panax Quinquefolius L) on Cardiometabolic Outcomes in Type 2 Diabetes: A Randomized, Controlled Trial
ConclusionCo-administration of Rg3-KRG+AG is an effective add-on for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 15, 2019 Category: Complementary Medicine Source Type: research