Therapeutic effects of Qianlie Tongli decoction on chronic prostatitis/chronic pelvic pain syndrome induced by peptide T2 in mice
ConclusionsThe results demonstrated the therapeutic effects of Qianlie Tongli decoction in CP/CPPS mice by analysing clinically relevant symptoms (urinary tract system, pelvic pain and prostate inflammation) and preliminarily explored the inflammatory ‐related treatment mechanisms by measuring TNF‐α. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 10, 2020 Category: Drugs & Pharmacology Authors: Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmad, Meng Tang, Junaid Wazir, Xiaohui Zhou, Lei Han Tags: Research Paper Source Type: research

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin ‐O‐glucuronide in HeLa1A1 cells
ConclusionsCYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 9, 2020 Category: Drugs & Pharmacology Authors: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Synthesis, characterization, antidiabetic and antioxidative evaluation of a novel Zn(II) ‐gallic acid complex with multi‐facet activity
ConclusionsData suggest that complexation of Zn(II) with gallic acid resulted in a complex with improved and multi ‐facet antioxidative and glycaemic control properties. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 8, 2020 Category: Drugs & Pharmacology Authors: Denice M. Motloung, Samson S. Mashele, Godfrey R. Matowane, Shasank S. Swain, Susanna L. Bonnet, Anwar E.M. Noreljaleel, Sunday O. Oyedemi, Chika I. Chukwuma Tags: Research Paper Source Type: research

By reducing oxidative stress, naringenin mitigates hyperglycaemia ‐induced upregulation of hepatic nuclear factor erythroid 2‐related factor 2 protein
ConclusionsNaringenin confers hepatoprotective antioxidant effects by initially preventing upregulation of Nrf2 protein expression and its downstream antioxidant enzymes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 6, 2020 Category: Drugs & Pharmacology Authors: Lereko Kometsi, Khmera Govender, Edith P. Mofo Mato, Rajendraparsad Hurchund, Peter M. O. Owira Tags: Research Paper Source Type: research

Protective effects of Sosihotang extract against ultraviolet B ‐induced skin photoageing in hairless mice
ConclusionsThese results indicate that SSH extract can be used therapeutically for the treatment of UVB ‐induced skin damage and photoageing. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 2, 2020 Category: Drugs & Pharmacology Authors: A ‐Rang Im, Kon‐Young Ji, Kung‐Woo Nam, Sungwook Chae Tags: Research Paper Source Type: research

The effect of apatinib on pharmacokinetic profile of buspirone both in vivo and in vitro
ConclusionsApatinib suppresses the CYP450 based metabolism of buspirone in a mixed mechanism and boosted the blood exposure of prototype drug and 6 ‐OH buspirone dramatically. Therefore, extra caution should be taken when combining apatinib with buspirone in clinic. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 30, 2020 Category: Drugs & Pharmacology Authors: Xiao ‐dan Zhang, Ying‐hui Li, Dao‐xing Chen, Wei‐wei You, Xiao‐xia Hu, Bing‐bing Chen, Guo‐xin Hu, Jian‐chang Qian Tags: Research Paper Source Type: research

Dual effects of S ‐adenosyl‐methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+
Conclusions(1) SAM might induce neurotoxic or neuroprotective effects on PC12 cells, depending on the exposure conditions; (2) DNMT inhibitors might attenuate the MPP+ exacerbation toxicity induced by SAM; (3) DNA methylation might be involved in the observed effects of SAM (needs further investigation). (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 29, 2020 Category: Drugs & Pharmacology Authors: Rebeca Araujo Cantelmo, Neife Aparecida G. Santos, Antonio Cardozo Santos, S âmia Regiane Lourenço Joca Tags: Research Paper Source Type: research

1 ‐(4‐((5‐chloro‐4‐((2‐(isopropylsulfonyl)phenyl)amino)pyrimidin‐2‐yl)amino)‐3‐methoxyphenyl)‐3‐(2‐(dimethylamino)ethyl)imidazolidin‐2‐one (ZX‐42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells
ConclusionsIn summary, ZX ‐42 is a novel ALK inhibitor that significantly inhibits the cell viability of H2228 cells and ultimately induces apoptosis through the mitochondrial pathway, in which autophagy plays a protective role. Therefore, inhibition of autophagy might enhance the anti‐cancer effect of ZX‐42. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Lijing Wang, Xiaobo Xu, Tong Liu, Junfang Wang, Jiwei Shen, Ming Guo, Yingliang Wu, Xin Zhai, Daiying Zuo Tags: Research Paper Source Type: research

A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
Conclusions(34Pro,35Phe)CGRP27 –37 is a potent CGRP receptor antagonist bothin vitro andin vivo, and it can be formulated as a dry powder with no loss of activity indicating its potential as a nasally formulated anti ‐migraine medicine. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 25, 2020 Category: Drugs & Pharmacology Authors: Bengt Mentzer, Andrew F. Russo, Zhang Zhongming, Adisa Kuburas, Patrick M. Killoran, Vera D ’Aloisio, Laura Nizic, Vicky Capel, David A. Kendall, Christopher R. Coxon, Gillian A. Hutcheon Tags: Research Paper Source Type: research

Nose ‐to‐brain delivery of sumatriptan‐loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation
ConclusionsNeuropharmacokinetic evaluation of intranasal NLC dispersion represents a suitable brain delivery system. The DTP of NLC formulation suggests the desirable entrance of sumatriptan into the brain. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 24, 2020 Category: Drugs & Pharmacology Authors: Moein Masjedi, Amir Azadi, Reza Heidari, Soliman Mohammadi ‐Samani Tags: Research Paper Source Type: research

In vitro metabolic characterization of orbitazine, a novel derivative of the PAC ‐1 anticancer agent
ConclusionsThisin vitro data on the metabolism of orbitazine may provide valuable information to support further clinical progression as a potential therapeutic molecule. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 24, 2020 Category: Drugs & Pharmacology Authors: Fang Li, Xuhua Han, Yanfen Chen, Shanshan Wang, Zeneng Cheng, Gaoyun Hu, Wenjie Liu, Qubo Zhu Tags: Research Paper Source Type: research

An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury
ConclusionsIcariin liposome has excellent therapeutic effects on acute blunt muscle injury in rats by improving immunity, repairing cytoskeleton and cellular integrity, anti ‐inflammation, anti‐fibrosis and antioxidant stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 22, 2020 Category: Drugs & Pharmacology Authors: Jinwu Wang, Gaosheng Zhu, Xingyu Wang, Jie Cai, Linzhen Xie, Wenhao Zheng, Yongzeng Feng, Qiang Guo, Hua Chen, Leyi Cai Tags: Research Paper Source Type: research

Cumulative effects of ciprofloxacin and pilocarpine on cytotoxicity and G0 phase arrest in hepatoma ‐derived Hep G2 cell line
ConclusionsCiprofloxacin imposed mitochondrial ‐independent apoptosis while PILO + CPF caused mitochondrial‐dependent and independent apoptosis simultaneously. Consequently, coadministration of PILO and CPF causes intense cytotoxic effects through targeting the mitochondria, DNA gyrase enzyme and other unknown mechanisms. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 21, 2020 Category: Drugs & Pharmacology Authors: Leila Sadeghi, Somaiyeh Maleki, Gholamreza Dehghan Tags: Research Paper Source Type: research

Kaempferol ameliorates secretagogue ‐induced pseudo‐allergic reactions via inhibiting intracellular calcium fluctuation
ConclusionsThe inhibition of the process of PLC γ phosphorylation to Ca2+ mobilization represents a major strategy in Kaempferol ‐suppressed pseudo‐allergic reactions. Thus, Kaempferol could be considered as a therapeutic drug candidate for non‐IgE‐mediated allergic reactions or inflammations. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 18, 2020 Category: Drugs & Pharmacology Authors: Jiao Cao, Yuejin Wang, Shiling Hu, Yuanyuan Ding, Qianqian Jia, Jing Zhu, Hongli An Tags: Research Paper Source Type: research

LncRNA Fendrr inhibits hypoxia/reoxygenation ‐induced cardiomyocyte apoptosis by downregulating p53 expression
ConclusionsFendrr can inhibit H/R ‐induced cardiomyocyte apoptosis, which is partly through promoting the ubiquitination and degradation of p53 by increasing the binding of Cop1 and p53. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 15, 2020 Category: Drugs & Pharmacology Authors: Xiang Li, Liangchun Ni, Weixin Wang, Liang Zong, Bi Yao Tags: Research Paper Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page 1000-1000, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti ‐inflammatory molecule PH46A
ConclusionsThe observed profile of cytokine modulation (IL ‐6/ TNF‐α, IL‐8) and inhibition of release of NO and 5‐LOX may contribute to thein vivo effects demonstrated by indane dimers and PH46A (1) in murine models of colitis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Kit Chan, Neil Frankish, Tao Zhang, Abdulilah Ece, Aoife Cannon, Jacintha O'Sullivan, Helen Sheridan Tags: Research Paper Source Type: research

Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo
ConclusionsHuosu Yangwei oral liquid could inhibit mammalian CYPs and modulated the metabolic half ‐life of apatinib bothin vitro andin vivo. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Sheng ‐Quan Fang, Jian Huang, Feng Zhang, Hong‐Mei Ni, Qi‐Long Chen, Jun‐Ran Zhu, Zhi‐Chao Fu, Liang Zhu, Wei‐Wei Hao, Guang‐Bo Ge Tags: Research Paper Source Type: research

Pharmacological screening of fenofibrate ‐loaded solid dispersion in fructose‐induced diabetic rat
ConclusionsThis newly formulated SDF would be a promising alternative for conventional fenofibrate in treating hyperlipidaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Milon Kumar Ghosh, Mir Imam Ibne Wahed, Rafiqul Islam Khan, Anwar Habib, Ranjan Kumar Barman Tags: Research Paper Source Type: research

Encapsulation of curcumin into layered double hydroxides improve their anticancer and antiparasitic activity
ConclusionsLayered double hydroxides are good vehicles to improve stability, resistance to degradation of CUR, also they are useful to improve solubility, provide a controlled release and improve the cytotoxic activity. Additionally, it was shown that the composition of the M+2 cation of LDH affects its properties and structure and that this directly influences its biological activity. The findings are important to select the composition of the encapsulation vehicle for a specific activity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Filiberto Guti érrez‐Gutiérrez, Cecilia Sánchez‐Jiménez, Itzia Azucena Rangel‐Castañeda, Gregorio Guadalupe Carbajal‐Arízaga, Adriana Macaria Macías‐Lamas, Araceli Castillo‐Romero, Karina Jeanette Parra‐Saavedra Tags: Research Paper Source Type: research

Self ‐nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in‐vivo studies
This study investigates the effectiveness of self ‐nanoemulsifying drug delivery system (SNEDDS) in improving voriconazole transcorneal permeability.MethodsVoriconazole ‐SNEDDS was prepared with isopropyl myristate, PEG 400, Tween 80® and Span 80® and was subjected for physicochemical characterization after reconstitution with NaCl 0.9% (1/9; v/v).In ‐vitro antifungal activity was assessed and compared with the marketed formulation.In ‐vivo studies, namely ocular irritation test via modified Draize test and pharmacokinetic study, were investigated using rabbit as animal model.Key findingsVoriconazole ‐SNE...
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Bakoliarisoa Nivomalala Voahangy Rasoanirina, Mohamed Ali Lassoued, Karim Miladi, Zoarilala Razafindrakoto, Raja Cha âbane‐Banaoues, David Ramanitrahasimbola, Muriel Cornet, Souad Sfar Tags: Research Paper Source Type: research

Design of enamides as new selective monoamine oxidase ‐B inhibitors
ConclusionsThese results encourage further studies on the enamide scaffold as potential drug candidates for the treatment of Alzheimer's and Parkinson's diseases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Fathima Sahla Kavully, Jong Min Oh, Sanal Dev, Swafvan Kaipakasseri, Ashique Palakkathondi, Ajeesh Vengamthodi, Rinshana Fathima Abdul Azeez, Anna Rita Tondo, Orazio Nicolotti, Hoon Kim, Bijo Mathew Tags: Research Paper Source Type: research

Development of a Gaussian Process – feature selection model to characterise (poly)dimethylsiloxane (Silastic®) membrane permeation
ConclusionsThis study highlights important considerations in the development of relevant models and in the construction and use of the data sets used in such studies, particularly that highly correlated descriptors should be removed from data sets. Predictive models are improved by the methodology adopted in this study, notably the systematic evaluation of descriptors, rather than simply using any and all available descriptors, often based empirically onin vitro experiments. Such findings also have clear relevance to a number of other fields. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Yi Sun, Mark Hewitt, Simon C. Wilkinson, Neil Davey, Roderick G. Adams, Darren R. Gullick, Gary P. Moss Tags: Research Paper Source Type: research

Pyoluteorin induces cell cycle arrest and apoptosis in human triple ‐negative breast cancer cells MDA‐MB‐231
ConclusionOur studies revealed that pyoluteorin had potent proliferation inhibition against MDA ‐MB‐231 cells through arresting cell cycle at G2/M phase and inducing caspase ‐3‐dependent apoptosis by mitochondrial pathway, implying that pyoluteorin may be a potential lead compound for drug discovery of human triple‐negative breast cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Ting Ding, Luo ‐Jie Yang, Wei‐Dong Zhang, Yun‐Heng Shen Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page i-iv, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Treatment of diabetic peripheral neuropathy: a review
The objectives of this paper are to review current guidelines for the pharmacological management of DPN and to discuss research rel evant to the further development of pharmacological recommendations for the treatment of diabetic neuropathy.SummaryDiabetic neuropathy is a highly prevalent, disabling condition, the management of which is associated with significant costs. Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. All current guidelines advise a personalised approach with a low ‐dose start that is tailored to the maximum re...
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Maher R. Khdour Tags: Review Source Type: research

A trimethoxy flavonoid isolated from stem extract of Tabebuia chrysantha suppresses angiogenesis in angiosarcoma
ConclusionThe isolated flavonoid named TMF fromT.  chrysantha functions as specific regulators of target proteins of angiosarcoma. The STAT3 ‐MMP9 signalling may be used as an effective prognostic marker of angiosarcoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Siva Prasad Panda, Uttam Prasad Panigrahy, DSNBK Prasanth, Uma Sankar Gorla, Chakravarthi Guntupalli, Deba Prasad Panda, Bikash Ranjan Jena Tags: Research Paper Source Type: research

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin ‐sensitized guinea pigs
ConclusionsTectorigenin could inhibit pulmonary fibrosis and airway inflammation through TGF ‐β1/Smad signalling pathway and TLR4/NF‐κB signalling pathway. Therefore, tectorigenin might be a promising medicine to treat allergic asthma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Youpeng Wang, Weichao Jing, Wanying Qu, Zhiwei Liu, Di Zhang, Xiaoyu Qi, Lujia Liu Tags: Research Paper Source Type: research

Exploring the biotransformation of N ‐(2‐hydroxyphenyl)‐2‐propylpentanamide (an aryl valproic acid derivative) by CYP2C11, using in silico predictions and in vitro studies
ConclusionTherefore, rat liver CYP2C11 isoform is able to metabolize HO ‐AAVPA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Authors: Jessica Elena Mendieta ‐Wejebe, Arianna Silva‐Trujillo, Martiniano Bello, Humberto L. Mendoza‐Figueroa, Norma Lizeth Galindo‐Alvarez, Arnulfo Albores, Feliciano Tamay‐Cach, Martha Cecilia Rosales‐Hernández, Aurelio Romero‐Castro, J Tags: Research Paper Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page 1000-1000, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page i-iv, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 8, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Arginase inhibitory properties of flavonoid compounds from the leaves of Mulberry (Morus alba, Moraceae)
ConclusionsThese results demonstrated the attractive ability ofM.  alba to be a potential source for the discovery of new active products on vascular system. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 4, 2020 Category: Drugs & Pharmacology Authors: Kamel Arraki, Perle Totoson, Rym Attia, Andy Zedet, Marc Pudlo, Chokri Messaoud, C éline Demougeot, Corine Girard Tags: Research Paper Source Type: research

Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l ‐borneolum against cerebral ischaemia in rats
ConclusionsThe therapeutic effect ofl‐borneolum on cerebral ischaemia might be associated with the regulation of energy metabolism, thermogenesis and bile secretion. These metabolic changes and the core target changes, as well as the metabolic‐target pathway network, help to elucidate the mechanisms governing the effect ofl‐borneolum on cerebral ischaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 4, 2020 Category: Drugs & Pharmacology Authors: Yinxiao Jiang, Jianxia Wen, Wenwen Zhang, Zhijie Ma, Congen Zhang, Jian Wang, Yao Dai, Qichao Hu, Zhibei Li, Xiao Ma Tags: Research Paper Source Type: research

Pharmacological characterization of the cardiovascular effect of Nibethione: ex vivo, in vivo and in silico studies
ConclusionsNibethione showedin vivo antihypertensive andex vivo vasorelaxant effects with implication of voltage ‐dependent L‐type Ca2+ channel blocking, and this may contribute to the research of novel antihypertensive drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 4, 2020 Category: Drugs & Pharmacology Authors: Amanda S ánchez‐Recillas, Gabriel Navarrete‐Vázquez, Sergio Hidalgo‐Figueroa, Marcos Bonilla‐Hernández, Rolffy Ortiz‐Andrade, Maximiliano Ibarra‐Barajas, Víctor Yáñez‐Pérez, Juan Carlos Sánchez‐Salgado Tags: Research Paper Source Type: research

Arginase inhibitory properties of flavonoid compounds from the leaves of Mulberry (Morus alba, Moraceae)
ConclusionsThese results demonstrated the attractive ability ofM.  alba to be a potential source for the discovery of new active products on vascular system. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 4, 2020 Category: Drugs & Pharmacology Authors: Kamel Arraki, Perle Totoson, Rym Attia, Andy Zedet, Marc Pudlo, Chokri Messaoud, C éline Demougeot, Corine Girard Tags: Research Paper Source Type: research

Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l ‐borneolum against cerebral ischaemia in rats
ConclusionsThe therapeutic effect ofl‐borneolum on cerebral ischaemia might be associated with the regulation of energy metabolism, thermogenesis and bile secretion. These metabolic changes and the core target changes, as well as the metabolic‐target pathway network, help to elucidate the mechanisms governing the effect ofl‐borneolum on cerebral ischaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 4, 2020 Category: Drugs & Pharmacology Authors: Yinxiao Jiang, Jianxia Wen, Wenwen Zhang, Zhijie Ma, Congen Zhang, Jian Wang, Yao Dai, Qichao Hu, Zhibei Li, Xiao Ma Tags: Research Paper Source Type: research

Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism
ConclusionsTripterygium wilfordii chronotoxicity was associated with diurnal variations in triptolide pharmacokinetics and circadian expression of hepatic Cyp3a11 regulated by circadian clock. Our findings may have implications for improving TW treatment outcome with a chronotherapeutic approach. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 1, 2020 Category: Drugs & Pharmacology Authors: Huan Zhao, Yongbin Tong, Danyi Lu, Baojian Wu Tags: Research Paper Source Type: research

Brassinin, a brassica ‐derived phytochemical, regulates monocyte‐to‐macrophage differentiation and inflammatory responses in human monocytes and murine macrophages
ConclusionsBrassinin suppressed monocyte ‐to‐macrophage differentiation and inflammatory responses by differentially regulating Nrf2 and NF‐κB signallings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 22, 2020 Category: Drugs & Pharmacology Authors: Bobin Kang, Jisu Hwang, Hyeon ‐Son Choi Tags: Research Paper Source Type: research

Nanomedicine: a new paradigm to overcome drug incompatibilities
ConclusionsThere is a new era of exploiting nanomaterials in overcoming various types of physicochemical incompatibilities, with additional benefits of further improvements in pharmacokinetic profiles and pharmacological actions of the administered drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 21, 2020 Category: Drugs & Pharmacology Authors: Ayat Abdelkader, Heba A. Fathi, Mostafa A. Hamad, Mahmoud Elsabahy Tags: Review Source Type: research

Curcumin alleviates OGD/R ‐induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF‐κB to suppress inflammation and apoptosis
ConclusionsOur study manifested that curcumin might be a meritorious drug for the treatment of cerebral ischaemia by acting on CCL3. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 21, 2020 Category: Drugs & Pharmacology Authors: Chao Wang, Yong ‐Hong Yang, Liang Zhou, Xin‐Li Ding, Ying‐Chun Meng, Ke Han Tags: Research Paper Source Type: research

Nanomedicine: a new paradigm to overcome drug incompatibilities
ConclusionsThere is a new era of exploiting nanomaterials in overcoming various types of physicochemical incompatibilities, with additional benefits of further improvements in pharmacokinetic profiles and pharmacological actions of the administered drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 21, 2020 Category: Drugs & Pharmacology Authors: Ayat Abdelkader, Heba A. Fathi, Mostafa A. Hamad, Mahmoud Elsabahy Tags: Review Source Type: research

The inhibitory effects of shikonin and β,β‐dimethylacrylshikonin on tramadol metabolism in vitro and in vivo
ConclusionsThe results of this study suggest that shikonin and DSK can inhibit tramadol metabolism bothin vitro andin vivo. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 19, 2020 Category: Drugs & Pharmacology Authors: Mi Jin, Dawei Shi, Hui Jin, Ziye Zhou, Chenxiang Wang Tags: Research Paper Source Type: research

A çaí berries (Euterpe oleracea Mart.) dried extract improves ethanol‐induced ulcer in rats
ConclusionsOur findings suggest that DAE reduces the inflammation and maintains the oxidative balance of gastric mucosa, therefore being a promising natural resource or useful nutraceutical to protect gastric mucosa. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 19, 2020 Category: Drugs & Pharmacology Authors: Benhur Judah Cury, Thaise Boeing, Lincon Bordignon Somensi, Luisa Nath ália Bolda Mariano, Sergio Faloni Andrade, Eduardo Breviglieri, Luiz Carlos Klein‐Junior, Priscila Souza, Luisa Mota Silva Tags: Research Paper Source Type: research

The inhibitory effects of shikonin and β,β‐dimethylacrylshikonin on tramadol metabolism in vitro and in vivo
ConclusionsThe results of this study suggest that shikonin and DSK can inhibit tramadol metabolism bothin vitro andin vivo. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 19, 2020 Category: Drugs & Pharmacology Authors: Mi Jin, Dawei Shi, Hui Jin, Ziye Zhou, Chenxiang Wang Tags: Research Paper Source Type: research

Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress ‐induced depression rat model
ConclusionsCSGS produced an obvious antidepressant activity. The comprehensive and holistic metabolomics approach could be a powerful tool to study the intervention mechanism and the compatibility rule of traditional Chinese medicine. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 17, 2020 Category: Drugs & Pharmacology Authors: Hongye Zhang, Huimin Huang, Hui Song, Bonnie Chin, Hua Zheng, Junxiang Ruan, Fang Wu, Bang Cheng, Jinxia Wu, Xuwen Liu, Yonghong Liang, Fangming Song, Zhaoni Chen, Chaoling Tang, Shiyin Lu, Hongwei Guo, Zhongmei Zou, Zhiheng Su Tags: Research Paper Source Type: research