Expression of Concern
Journal of Pharmacy and Pharmacology, EarlyView. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 4, 2021 Category: Drugs & Pharmacology Tags: Expression of Concern Source Type: research

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
AbstractObjectivesThe myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available.Key findingsC2C12 is a well ‐documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular l...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Chun Y. Wong, Hani Al ‐Salami, Crispin R. Dass Tags: Review Source Type: research

Recent trends in targeting miRNAs for cancer therapy
AbstractObjectivesMicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities.Key findingsMicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNA...
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Vandit Shah, Jigna Shah Tags: Review Source Type: research

A comprehensive review of therapeutic approaches available for the treatment of cholera
ConclusionsKnowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Francisca B. M. Sousa, Isabela R. S. G. Nol êto, Leticia S. Chaves, Gabriella Pacheco, Ana P. Oliveira, Mikhail M. V. Fonseca, Jand V. R. Medeiros Tags: Review Source Type: research

Carissa carandas L. – phyto‐pharmacological review
ConclusionsThis current review offers primary data for further research work. The in ‐vitro evaluations as well as in‐vivo models/experiments have provided a biosynthetic observation for its various ethno‐pharmacological uses and even pharmacological properties. This review would provide all valuable information which will be beneficiary to conduct some important pharmacokinet ic and toxicological research works on human models with respect to ensure the effects of active ingredients in the body and even to validate its safety issues in clinical aspects. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Sonia Singh, Meenakshi Bajpai, Pradeep Mishra Tags: Review Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 12, Page i-iv, December 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Pinoresinol ‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
ConclusionsPinoresinol ‐4‐O‐β‐D‐glucopyranoside is a natural entity combating oxidative stress, hepatic damage and diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El ‐Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink Tags: Research Paper Source Type: research

The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
ConclusionsThis study could be a meaningful investigation to provide mechanistic insights into the hepatoprotective effect of lotus leaf and further lay a theoretical basis for the clinical application of lotus leaf. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi, Xiaohui Chen Tags: Research Paper Source Type: research

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
ConclusionsThe study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva Tags: Research Paper Source Type: research

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
ConclusionsA loading dose of up to 300  mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis Tags: Research Paper Source Type: research

Catechol protects against iron ‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
ConclusionThese results suggest the neuroprotective effects of catechol in iron ‐mediated oxidative brain injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Md. Shahidul Islam Tags: Research Paper Source Type: research

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu ‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
ConclusionsCYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad ‐spectrum inhibition of CYPs and UGTs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ ‐induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes
ConclusionKigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Oladapo F. Fagbohun, Babatunde Olawoye, Adedeji N. Ademakinwa, Kehinde A. Jolayemi, Titus A. M. Msagati Tags: Research Paper Source Type: research

Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra ‐performance liquid chromatography coupled time‐of‐flight mass spectrometry
ConclusionsThis work revealed thein ‐vivo metabolism of FF, and reported the characteristic metabolic reactions of lignans for the first time. It was also provided the foundation for the further investigation on pharmacodynamic components of FF or TCMs containing FF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Feng ‐xiang Zhang, Zi‐ting Li, Chang Li, Min Li, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai Tags: Research Paper Source Type: research

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin ‐O‐glucuronide in HeLa1A1 cells
ConclusionsCYP1A1 and CYP2C9, UGT1A1, UGT1A7, UGT1A8 and UGT1A9, and MRP4 all played important roles in the metabolism and disposition of bavachin. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti ‐inflammatory agent and as adjuvant in psoriasis therapy
ConclusionsThe results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: N ícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello S Tags: Research Paper Source Type: research

Therapeutic effects of a çaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
ConclusionsThe therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas Bem, Dayane Teixeira Ognibene, Ana Paula Machado Rocha, Roberto Soares Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar Costa Tags: Research Paper Source Type: research

Umbelliprenin relieves paclitaxel ‐induced neuropathy
ConclusionsUmbelliprenin alleviated neuropathic pain, and decreased serum IL ‐6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei Tags: Research Paper Source Type: research

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti ‐apoptotic and antioxidative activity
ConclusionsThis study emphasized the immune ‐modulatory and antioxidative effects of shikonin, which may have an important healing effect on the severity of EAE. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mehrdad Nasrollahzadeh Sabet, Sajjad Biglari, Hamid Reza Khorram Khorshid, Emran Esmaeilzadeh Tags: Research Paper Source Type: research

Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy, Gehad M. Elnagar, Marwa M.Elsawy, Abdelmoneim A. Ali, Nabila Zein Tags: Research Paper Source Type: research

Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
ConclusionsCollectively, we would suggest that geniposide may potentially be utilized as an adjunct to existing thiazide and thiazide ‐like diuretics to control hypertension, mainly through inhibiting the activation of the WNK signalling pathway mediated by the estrogen receptor. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Fu, Pei ‐pei Yuan, Yan‐gang Cao, Ying‐ying Ke, Qi Zhang, Ying Hou, Yan‐li Zhang, Wei‐sheng Feng, Xiao‐ke Zheng Tags: Research Paper Source Type: research

Recombinant ling zhi ‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
ConclusionsThese data suggest that rLZ ‐8 can antagonize STZ‐induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 12, Page i-iv, December 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 11, Page i-iv, November 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - October 5, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
ConclusionsThis study could be a meaningful investigation to provide mechanistic insights into the hepatoprotective effect of lotus leaf and further lay a theoretical basis for the clinical application of lotus leaf. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 25, 2020 Category: Drugs & Pharmacology Authors: Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi, Xiaohui Chen Tags: Research Paper Source Type: research

Umbelliprenin relieves paclitaxel ‐induced neuropathy
ConclusionsUmbelliprenin alleviated neuropathic pain, and decreased serum IL ‐6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 14, 2020 Category: Drugs & Pharmacology Authors: Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 10, Page i-iv, October 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 9, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Catechol protects against iron ‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
ConclusionThese results suggest the neuroprotective effects of catechol in iron ‐mediated oxidative brain injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 8, 2020 Category: Drugs & Pharmacology Authors: Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Md. Shahidul Islam Tags: Research Paper Source Type: research

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti ‐apoptotic and antioxidative activity
ConclusionsThis study emphasized the immune ‐modulatory and antioxidative effects of shikonin, which may have an important healing effect on the severity of EAE. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 5, 2020 Category: Drugs & Pharmacology Authors: Mehrdad Nasrollahzadeh Sabet, Sajjad Biglari, Hamid Reza Khorram Khorshid, Emran Esmaeilzadeh Tags: Research Paper Source Type: research

Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 2, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy, Gehad M. Elnagar, Marwa M.Elsawy, Abdelmoneim A. Ali, Nabila Zein Tags: Research Paper Source Type: research

Therapeutic effects of a çaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
ConclusionsThe therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Authors: Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas Bem, Dayane Teixeira Ognibene, Ana Paula Machado Rocha, Roberto Soares Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar Costa Tags: Research Paper Source Type: research

Pinoresinol ‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
ConclusionsPinoresinol ‐4‐O‐β‐D‐glucopyranoside is a natural entity combating oxidative stress, hepatic damage and diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Authors: Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El ‐Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink Tags: Research Paper Source Type: research

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti ‐inflammatory agent and as adjuvant in psoriasis therapy
ConclusionsThe results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 25, 2020 Category: Drugs & Pharmacology Authors: N ícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello S Tags: Research Paper Source Type: research

Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
ConclusionsCollectively, we would suggest that geniposide may potentially be utilized as an adjunct to existing thiazide and thiazide ‐like diuretics to control hypertension, mainly through inhibiting the activation of the WNK signalling pathway mediated by the estrogen receptor. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 23, 2020 Category: Drugs & Pharmacology Authors: Yang Fu, Pei ‐pei Yuan, Yan‐gang Cao, Ying‐ying Ke, Qi Zhang, Ying Hou, Yan‐li Zhang, Wei‐sheng Feng, Xiao‐ke Zheng Tags: Research Paper Source Type: research

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence
ConclusionsThe study expands the understanding of the pharmacological properties of Berberine and its applicability as a radiosensitizer towards treating liver cancer. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 19, 2020 Category: Drugs & Pharmacology Authors: Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva Tags: Research Paper Source Type: research

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis
AbstractObjectivesRheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self ‐neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self‐epitopes as biomarkers in RA provides a better understanding of pathogenesis of disease and has led to the development of novel the rapeutic approaches acting as potent inhibitors of these cells.Key findingsThe current review retrieved the various medicinal plant...
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Shareen Singh, Thakur Gurjeet Singh, Kriti Mahajan, Sonia Dhiman Tags: Review Source Type: research

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage
AbstractObjectivesThe myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available.Key findingsC2C12 is a well ‐documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular l...
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Chun Y. Wong, Hani Al ‐Salami, Crispin R. Dass Tags: Review Source Type: research

Metabolome modulatory effects of Kigelia africana (Lam.) Benth. fruit extracts on oxidative stress, hyperlipidaemic biomarkers in STZ ‐induced diabetic rats and antidiabetic effects in 3T3 L1 adipocytes
ConclusionKigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stress. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 17, 2020 Category: Drugs & Pharmacology Authors: Oladapo F. Fagbohun, Babatunde Olawoye, Adedeji N. Ademakinwa, Kehinde A. Jolayemi, Titus A. M. Msagati Tags: Research Paper Source Type: research

Recombinant ling zhi ‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
ConclusionsThese data suggest that rLZ ‐8 can antagonize STZ‐induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 16, 2020 Category: Drugs & Pharmacology Authors: Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang Tags: Research Paper Source Type: research

9 ‐PAN promotes tubulin‐ and ROS‐mediated cell death in human triple‐negative breast cancer cells
Conclusions9 ‐PAN exerts its antiproliferative effect by targeting tubulin and elevating ROS level in the cells. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 15, 2020 Category: Drugs & Pharmacology Authors: Prachi Verma, Praveen Kumar Reddy Nagireddy, Shweta Shyam Prassanawar, Jesuthankaraj Grace Nirmala, Ankita Gupta, Srinivas Kantevari, Manu Lopus Tags: Research Paper Source Type: research

Inhibiting the PI3K/Akt, NF ‐κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131
ConclusionsTherefore, addition of SRA to SCC131 cells may provide a promising natural therapeutic strategy against squamous cell carcinomas with potential application in clinical analysis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 12, 2020 Category: Drugs & Pharmacology Authors: Periyannan Velu, Annamalai Vijayalakshmi, Veerasamy Vinothkumar Tags: Research Paper Source Type: research

Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?
ConclusionsA loading dose of up to 300  mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 11, 2020 Category: Drugs & Pharmacology Authors: Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis Tags: Research Paper Source Type: research

Recent trends in targeting miRNAs for cancer therapy
AbstractObjectivesMicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development of new diagnostic and therapeutic opportunities.Key findingsMicroRNA dysregulation is commonly associated with cancer, in part because miRNAs are actively involved in the mechanisms like genomic instabilities, aberrant transcriptional control, altered epigenetic regulation and biogenesis machinery defects. MicroRNA...
Source: Journal of Pharmacy and Pharmacology - August 11, 2020 Category: Drugs & Pharmacology Authors: Vandit Shah, Jigna Shah Tags: Review Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 9, Page i-iv, September 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 9, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 9, Page 1287-1287, September 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 9, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Black mulberry fruit extract alleviates streptozotocin ‐induced diabetic nephropathy in rats: targeting TNF‐α inflammatory pathway
ConclusionThe ameliorative effect of BMFE on diabetic nephropathy is not only through its potent antioxidant and hypoglycaemic effects but also through its downregulation of TNF ‐α, VCAM‐1 and fibronectin mRNA expression in renal tissues of diabetic‐treated rats. Therefore, BMFE as dietary supplement could be a promising agent in improving diabetic nephropathy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Tarek Kamal Abouzed, Kadry M. Sadek, Emad Waded Ghazy, Walied Abdo, Mohmed Atef Kassab, Salma Hago, Samia Abdel ‐Wahab, Engy A. Mahrous, Essam Abdel‐Sattar, Doaa H. Assar Tags: Research Paper Source Type: research

Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra ‐performance liquid chromatography coupled time‐of‐flight mass spectrometry
ConclusionsThis work revealed thein ‐vivo metabolism of FF, and reported the characteristic metabolic reactions of lignans for the first time. It was also provided the foundation for the further investigation on pharmacodynamic components of FF or TCMs containing FF. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Feng ‐xiang Zhang, Zi‐ting Li, Chang Li, Min Li, Zhi‐hong Yao, Xin‐sheng Yao, Yi Dai Tags: Research Paper Source Type: research

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus
ConclusionsThe inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components inL.  japonicus. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Grace Gar ‐Lee Yue, Xin‐Xin Liang, Xiao‐Li Li, Julia Kin‐Ming Lee, Si Gao, Hin‐Fai Kwok, Clara Bik‐San Lau, Wei‐Lie Xiao Tags: Research Paper Source Type: research

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu ‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases
ConclusionsCYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad ‐spectrum inhibition of CYPs and UGTs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao Tags: Research Paper Source Type: research

Modulation of NADPH oxidase and Nrf2/HO ‐1 pathway by vanillin in cisplatin‐induced nephrotoxicity in rats
ConclusionsThe antioxidant mechanism by which vanillin protected against CP ‐induced nephrotoxicity involved the inhibition ofNOX ‐4 along with the stimulation of Nrf2/HO ‐1 signalling pathway. These in turn inhibited inflammation and apoptosis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 2, 2020 Category: Drugs & Pharmacology Authors: Nahla N. Younis, Nehal M Elsherbiny, Mohamed A. Shaheen, Mohamed M. Elseweidy Tags: Research Paper Source Type: research