Lymphatic clearance is the main drainage route of lamotrigine ‐loaded micelles following delivery to the brain
This study aimed to investigate the clearance pathways of lamotrigine (LTG) ‐loaded micelles by intranasal administration and intracerebral injection in the brain and whether nanoparticles can induce the inflammation promoted by interleukin‐6 (IL‐6), accelerating the phagocytosis of drug particles in the brain and drainage through lymphatics.MethodsThe drug concentrations in the deep cervical lymph node, superficial cervical lymph node, brain tissues and jugular vein, the pharmacokinetic parameters, and the concentrations of IL ‐6 in deep cervical lymph node and brain tissues were investigated following UPLC/MS, DA...
Source: Journal of Pharmacy and Pharmacology - July 17, 2019 Category: Drugs & Pharmacology Authors: Jiaqi Yan, Jialin Ren, Yu Zhu, Yanzhen Lin, Gang Chen, Dongzhi Hou, Zhufen Lv, Jiaxin Zhou, Yanzhong Chen, Fan Yang Tags: Research Paper Source Type: research

Advancements in nanotherapeutics for Alzheimer ’s disease: current perspectives
AbstractObjectives Considerable progress has been made in the treatment of Alzheimer’s disease (AD), but all available strategies focus on alleviating symptoms rather than curing, which means that AD is viewed as an unresolvable neurodegenerative disease. Nanotechnological applications offer an alternative platfor m for the treatment of neurodegenerative diseases. This review aims to summarize the recent nanomedicine and nanotechnology developments for the treatment of AD. Key findings A plethora of nanocarriers and nanoparticle prodrugs have been reported to have negligible cytotoxicity in animal mode...
Source: Journal of Pharmacy and Pharmacology - July 15, 2019 Category: Drugs & Pharmacology Authors: Seetha Harilal, Jobin Jose, Della Grace Thomas Parambi, Rajesh Kumar, Githa Elizabeth Mathew, Md. Sahab Uddin, Hoon Kim, Bijo Mathew Tags: Review Source Type: research

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review
AbstractObjectiveOsteoporosis is a skeletal disease with decreased bone mass and alteration in microarchitecture of bone tissue, and these changes put patients in risk of bone fracture. As a common symptom of osteoporosis and complication of osteoporotic fracture, chronic pain is a headache for clinicians. Nonsteroidal anti ‐inflammatory drugs (NSAIDs), selective COX‐2 inhibitors and opioid drugs can temporarily reduce osteoporotic pain but have relevant side effects, such as addiction, tolerability and safety. The review summarized the recent advancements in the study of CB receptors in osteoporosis and osteoporot ic ...
Source: Journal of Pharmacy and Pharmacology - July 11, 2019 Category: Drugs & Pharmacology Authors: Jing Wang, Hong ‐xia Lu, Jing Wang Tags: Review Source Type: research

Basic fibroblast growth factor signalling regulates cancer stem cells in lung cancer A549 cells
ConclusionsIn conclusion, our study suggested that bFGF/FGFR signalling plays an important role in maintaining lung cancer stem cell characteristics and regulating expression of cancer stem cell marker of OCT ‐4. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 8, 2019 Category: Drugs & Pharmacology Authors: Yousheng Meng, Xiaoyan Bai, Yuandong Huang, Lang He, Zhengwei Zhang, Xia Li, Dandan Cui, Xuemei Yang Tags: Research Paper Source Type: research

Phyltetralin, 1,7,8 ‐trihydroxy 2‐naphtaldehyde, ethyl 8‐hydroxy‐8‐methyl‐tridecanoate and 1‐triacontanol from Phyllanthus amarus Schumach. & Thonn. inhibit phagocytic activity of human leucocytes
ConclusionCompounds isolated fromP.  amarus possessed immunosuppressive effects on different lineages of innate immune system. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 8, 2019 Category: Drugs & Pharmacology Authors:   Yuandani, Ibrahim Jantan, Khairana Husain Tags: Research Paper Source Type: research

AMPK ‐SIRT1‐independent inhibition of ANGPTL3 gene expression is a potential lipid‐lowering mechanism of metformin
ConclusionsMetformin inhibits ANGPTL3 expression in the liver in an AMPK ‐SIRT1‐independent manner as a potential mechanism to regulate LPL and lower plasma lipids. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 5, 2019 Category: Drugs & Pharmacology Authors: Li Lin, Jamie Burke, Sahana Venkatesh, Prabodh Sadana Tags: Research Paper Source Type: research

A new strategy for taste masking on bitter drug by other combined drug in fixed ‐dose combination: bitterness of Amlodipine besylate could be masked efficiently by Valsartan
ConclusionsIt was suggested that when VAL was mixed with AML, the electrostatic interactions between positive charged amino group of AML and negative charged tetrazole group of VAL were caused, and thereby led the suppression the bitterness of AML. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 5, 2019 Category: Drugs & Pharmacology Authors: Honami Kojima, Saki Nakamura, Tamami Haraguchi, Miyako Yoshida, Masaaki Habara, Hidekazu Ikezaki, Takahiro Uchida Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 71, Issue 8, Page i-iv, August 2019. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Pegfilgrastim and linagliptin potentiate chemoattraction of Ccr2 and Cd44 stem cells accompanied by alterations of cardiac Hgf, Igf ‐1 and Mcp‐1 in daunorubicin cardiomyopathy
ConclusionAlthough PFIL  + LINA failed in universal potentiation of stem cells migration and homing, the expression of stem cell markers Ccr2 and Cd44 in the heart potentially increased through the preservation of Hgf, Igf‐1 and upregulation of Mcp‐1. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Authors: Jasna Srankova, Jana Veteskova, Margareta Marusakova, Lenka Pivackova, Gabriel Doka, Peter Krenek, Jan Klimas Tags: Research Paper Source Type: research

Cordycepin regulates body weight by inhibiting lipid droplet formation, promoting lipolysis and recruiting beige adipocytes
ConclusionsCordycepin could blockade lipid droplet formation and promote lipid droplet degradation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 1, 2019 Category: Drugs & Pharmacology Authors: Hongyue Xu, Bingjie Wu, Xueyan Wang, Fangxue Ma, Yan Li, Yanan An, Chao Wang, Xuefei Wang, Wenjing Luan, Shulin Li, Mingyuan Liu, Jianyi Xu, Hongjuan Wang, Xudong Tang, Lu Yu Tags: Research Paper Source Type: research

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
AbstractObjectivesScutellaria baicalensis Georgi. (Lamiaceae) is a plant of the genus Lamiaceae, and its root is the main part used as a medicine. In China,Scutellaria baicalensis is still an important traditional Chinese medicine with the functions of clearing away heat and dampness, purging fire and detoxification. This medicinal plant is widely distributed in China, Russia, Mongolia, North Korea and Japan. The purpose of this paper was to provide a systematic and comprehensive overview on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics and toxicology of this plant. Furthermore, the possibl...
Source: Journal of Pharmacy and Pharmacology - June 24, 2019 Category: Drugs & Pharmacology Authors: Tiantian Zhao, Hailong Tang, Long Xie, Yu Zheng, Zubing Ma, Qiang Sun, Xiaofang Li Tags: Review Source Type: research

Antioxidant and anticancer activity of synthesized 4 ‐amino‐5‐((aryl substituted)‐4H‐1,2,4‐triazole‐3‐yl)thio‐linked hydroxamic acid derivatives
ConclusionsAfter the assessment of all in vivo anticancer study related data, it was found that compound6b possess superior anticancer potency in terms of efficacy and toxicity. From this experimental design, it could be concluded that further modification of this prototypical structure will lead to develop more potent antioxidant as well as an anticancer agent in the future. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 19, 2019 Category: Drugs & Pharmacology Authors: Mousumi Das, Bhaskar Das, Amalesh Samanta Tags: Research Paper Source Type: research

A novel SGLT2 inhibitor, SU ‐011, improves glycaemic control in rodents without the risk of hypoglycaemia and weight gain
ConclusionsAll of these results indicated that SU ‐011 may be effective for the management of diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 19, 2019 Category: Drugs & Pharmacology Authors: Fei Huang, Fuwei Dai, Jianhua Bi, Lanxiang Hao, Chunlei Wang, Ke Xu, Yanmei Liu, Xingbo Cheng Tags: Research Paper Source Type: research

Vitamin E D ‐alpha‐tocopheryl polyethylene glycol 1000 succinate‐conjugated liposomal docetaxel reverses multidrug resistance in breast cancer cells
ConclusionsThe TPGS ‐conjugated liposomes showed significant advantagesin vitro compared with the PEG ‐conjugated liposomes. The TPGS‐conjugated liposomes could reverse the MDR and enhance breast cancer therapy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 18, 2019 Category: Drugs & Pharmacology Authors: Na Li, Tingting Fu, Wenling Fei, Tianyan Han, Xiangshuai Gu, Yanhui Hou, Yanhua Liu, Jianhong Yang Tags: Research Paper Source Type: research

Soluble epoxide hydrolase inhibitor, TUPS, attenuates isoproterenol/angiotensin II ‐induced cardiac hypertrophy through mammalian target of rapamycin‐mediated autophagy inhibition
ConclusionsTUPS inhibits cardiac hypertrophy by regulating mTOR/autophagy axis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 18, 2019 Category: Drugs & Pharmacology Authors: Huanji Zhang, Kun Zhang, Jianwen Liang, Wen Yan, Fensheng Wu, Wenmin Xu, Zhiwen Wu, Yixi Chen, Rongquan Pan, Guifu Wu Tags: Research Paper Source Type: research

The effects of atorvastatin on the kidney injury in mice with pulmonary fibrosis
ConclusionsThe depletion of MAPK signals, rather than SMAD signalling, is effective in kidney damage of mice with PF. Atorvastatin did not regress kidney damage in these mice, whereas it increases the kidney injury. The c ‐Jun‐mediated JNK signals could help kidney repair through cell proliferation. The treatment time and doses of atorvastatin should be optimized for regression of kidney damage. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 18, 2019 Category: Drugs & Pharmacology Authors: Ayse Karatug Kacar, Merve Yildirim, Sehnaz Bolkent, Fusun Oztay Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 71, Issue 7, Page i-iv, July 2019. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Novel cuminaldehyde self ‐emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride‐treated mice
ConclusionsThese findings showed that the improved bioavailability of cuminaldehyde via SEN provided an effective approach for enhancing antioxidation, anti ‐inflammation and antihepatotoxicity of the drug. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 5, 2019 Category: Drugs & Pharmacology Authors: Michael Adu ‐Frimpong, Wei Qiuyu, Caleb Kesse Firempong, Yusif Mohammed Mukhtar, Qiuxuan Yang, Emmanuel Omari‐Siaw, Zhen Lijun, Ximing Xu, Jiangnan Yu Tags: Research Paper Source Type: research

Demonstrating suitability of the Caco ‐2 cell model for BCS‐based biowaiver according to the recent FDA and ICH harmonised guidelines
ConclusionsAssay standardisation assures the consistency of experimental data. Only such fully characterised model has the ability to accurately predict drug's intestinal permeability at the early stage of research or for the BCS ‐based biowaiver application. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 2, 2019 Category: Drugs & Pharmacology Authors: Tina Jarc, Ma ša Novak, Neli Hevir, Tea Lanišnik Rižner, Mateja Erdani Kreft, Katja Kristan Tags: Research Paper Source Type: research

Desferrioxamine and dextromethorphan combination exhibited synergistic effect and reversed the catalepsy behaviour in 6 ‐hydroxydopamine hydroydopamine administered rats through regulating brain glutamate levels
ConclusionsThe reversal of catalepsy behaviour represents the protective effect of above combination on dopamine neurons in striatum from 6 ‐OHDA toxicity. The mechanism of DFO and DXM combination might be attributed through attenuation of glutamate‐induced excitotoxicity in neurons through ameliorating the reactive oxygen species and pro‐inflammatory cytokines release. Treatment with DFO and DXM combination could control the mult iple events in the pathogenesis of PD. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 29, 2019 Category: Drugs & Pharmacology Authors: Navaf Mannan Thodukayil, Justin Antony, Peet Thomas, Victoria Jeyarani, Tenzin Choephel, Chennu Manisha, Asha Jose, Santilna Karolina Sahadevan, Elango Kannan Tags: Research Paper Source Type: research

Antiretroviral agents in pre ‐exposure prophylaxis: emerging and advanced trends in HIV prevention
AbstractObjectivesAntiretroviral agents (ARVs) have been the most promising line of therapy in the management of human immunodeficiency virus (HIV) infections. Some of these ARVs are used in the pre ‐exposure prophylaxis (PrEP) to suppress the transmission of HIV. Prophylaxis is primarily used in uninfected people, before exposure, to effectively prevent HIV infection. Several studies have shown that ART PrEP prevents HIV acquisition from sexual, blood and mother‐to‐child transmissions. H owever, there are also several challenges and limitations to PrEP. This review focuses on the current antiretroviral therapies use...
Source: Journal of Pharmacy and Pharmacology - May 29, 2019 Category: Drugs & Pharmacology Authors: Pui Khee Yap, Griselda Lim Loo Xin, Yoke Ying Tan, Jestin Chellian, Gaurav Gupta, Yun Khoon Liew, Trudi Collet, Kamal Dua, Dinesh Kumar Chellappan Tags: Review Source Type: research

Crude polysaccharide from a wild mushroom enhances immune response in murine macrophage cells by TLR/NF ‐κB pathway
ConclusionsOverall, the results portrayed possibility of MLHWP as pharmaceutical agent with multidimensional application. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 28, 2019 Category: Drugs & Pharmacology Authors: Sandipta Ghosh, Somanjana Khatua, Krishnendu Acharya Tags: Research Paper Source Type: research

Rectus sheath single ‐injection blocks: a study to quantify local anaesthetic absorption using serial ultrasound measurements and lidocaine serum concentrations
ConclusionsThe study provides the first data describing lidocaine pharmacokinetics after rectus sheath injection. Peak serum concentrations transiently achieved systemic levels associated with pain relief after a single bolus injection. The data from this study could be used to develop a regime using single shot rectus sheath blockade with a bolus of lidocaine followed by infusion using bilateral rectus sheath catheters. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 27, 2019 Category: Drugs & Pharmacology Authors: Matthew Primrose, Hamdah Al Nebaihi, Dion R. Brocks, Sandy Widder, Adrian Fairey, Ban Tsui, Derek Dillane, James S. Green Tags: Research Paper Source Type: research

Single ‐dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging
AbstractObjectivesWe investigated changes of renal perfusion after topical and oral diclofenac administration in healthy volunteers using functional magnetic resonance imaging (MRI) with arterial spin labelling (ASL).MethodsTwenty ‐four healthy human participants (21–51 years) underwent 1.5T MRI before and 1 h after a single oral dose of diclofenac (50 mg). Twelve of 24 participants underwent an additional MRI examination following 3‐day topical diclofenac administration. For renal perfusion imaging, a flow‐sensiti ve alternating inversion‐recovery TrueFISP ASL sequence was applied. Plasma conc...
Source: Journal of Pharmacy and Pharmacology - May 27, 2019 Category: Drugs & Pharmacology Authors: Susanne Hellms, Faikah Gueler, Marcel Gutberlet, Nils Helge Schebb, Katharina Rund, Jan T. Kielstein, VanDai VoChieu, Sebastian Rauhut, Robert Greite, Petros Martirosian, Hermann Haller, Frank Wacker, Katja Derlin Tags: Research Paper Source Type: research

Vancomycin ‐loaded niosomes integrated within pH‐sensitive in‐situ forming gel for treatment of ocular infections while minimizing drug irritation
ConclusionsThe developed formulations demonstrated promising in ‐vivo biocompatibility and antibacterial efficacy, signifying their potential application as ophthalmic preparation to overcome ocular infections induced by resistant bacterial strains while minimizing drug irritation and improving patient compliance. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 24, 2019 Category: Drugs & Pharmacology Authors: Ayat Allam, Mohamed A. El ‐Mokhtar, Mahmoud Elsabahy Tags: Research Paper Source Type: research

Development, physico ‐chemical characterization and in‐vitro studies of hydrogels containing rosmarinic acid‐loaded nanoemulsion for topical application
ConclusionsThe overall results demonstrated that the formulations developed in this study can be considered as a suitable carrier for RA in a topical application targeting new anti ‐ageing skin care products. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 24, 2019 Category: Drugs & Pharmacology Authors: Paula Marafon, Fl ávia Nathiely Silveira Fachel, Morgana Dal Prá, Valquíria Linck Bassani, Letícia Scherer Koester, Amélia Teresinha Henriques, Elizandra Braganhol, Helder Ferreira Teixeira Tags: Research Paper Source Type: research

An evaluation of cetuximab dosing strategies using pharmacokinetics and cost analysis
ConclusionsCost ‐effectiveness of cetuximab treatment can be improved with alternative strategies by reducing wastage without compromising exposure. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 24, 2019 Category: Drugs & Pharmacology Authors: Kayode Ogungbenro, Alkesh Patel, Mark Saunders, James Clark, Robert Duncombe Tags: Research Paper Source Type: research

S ‐nitrosoglutathione protects lipopolysaccharide‐induced acute kidney injury by inhibiting toll‐like receptor 4–nuclear factor‐κB signal pathway
ConclusionsS ‐nitrosoglutathione attenuates the severity of LPS‐induced AKI by inhibiting the TLR4–NF‐κB signalling pathway and may act as a protective agent for septic AKI. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 22, 2019 Category: Drugs & Pharmacology Authors: Heng Fan, Yu Zhao, Jian ‐Hua Zhu Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 71, Issue 6, Page i-iv, June 2019. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 7, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites
AbstractObjectivesThis review highlights both the physicochemical characteristics of the nanocarriers (NCs) and the physiological features of tumour microenvironment (TME) to outline what strategies undertaken to deliver the molecules of interest specifically to certain lesions. This review discusses these properties describing the convenient choice between passive and active targeting mechanisms with details, illustrated with examples of targeting agents up to preclinical research or clinical advances.Key findingsTargeted delivery approaches for anticancers have shown a steep rise over the past few decades. Though many su...
Source: Journal of Pharmacy and Pharmacology - May 3, 2019 Category: Drugs & Pharmacology Authors: Mohamed F. Attia, Nicolas Anton, Justine Wallyn, Ziad Omran, Thierry F. Vandamme Tags: Review Source Type: research

Anti ‐inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
ConclusionsThe anti ‐inflammatory and antitumour effects of SE were better than those of the other two extracts. The compounds responsible for the activity were elucidated. SE and piperine inhibit cell growth through apoptosis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 3, 2019 Category: Drugs & Pharmacology Authors: Ziyan Guo, Jie Xu, Jianhua Xia, Zi Wu, Jiachuan Lei, Jianqing Yu Tags: Research Paper Source Type: research

In ‐vitro and in situ assessment of the efflux of five antidepressants by breast cancer resistance protein
This study aimed to identify whether five commonly used antidepressants (sertraline, duloxetine, fluoxetine, amitriptyline and mirtazapine) are BCRP substrates.MethodsA combination of bidirectional transport and intracellular accumulation experiments was conducted on BCRP ‐overexpressing MDCKII and wild‐type (WT) cells, andin  situ brain perfusion was conducted in rats.Key findingsThe bidirectional transport study revealed that the net efflux ratio (NER) of sertraline reached 2.08 but decreased to 1.06 when co ‐incubated with Ko143, a selective BCRP inhibitor. Conversely, the other four antidepressants did not a...
Source: Journal of Pharmacy and Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Authors: Suqin Feng, Liang Zheng, Shiwei Tang, Juan Gu, Xuehua Jiang, Ling Wang Tags: Research Paper Source Type: research

Simultaneous determination of 19 mycotoxins in lotus seed using a multimycotoxin UFLC ‐MS/MS method
This study aimed to develop a sensitive method for accurate assessment of multimycotoxin residues in lotus seeds.MethodsA simple and reliable modified ultrasonication ‐assisted extraction, QuEChERS purification based ultrafast liquid chromatography tandem mass spectrometry (UFLC‐MS/MS) method was successfully developed for ultrasensitive determination of 19 multiclass mycotoxins in starch‐rich lotus seeds. Four extraction modes and three clean‐up sorbents for improving the recoveries of mycotoxins were optimized. Limits of detection (LODs) and quantification, linearity, precision, accuracy, and matrix effect were s...
Source: Journal of Pharmacy and Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Authors: Fang Wei, Xiaofei Liu, Xiaofang Liao, Linchun Shi, Shuwei Zhang, Jinghua Lu, Lidong Zhou, Weijun Kong Tags: Research Paper Source Type: research

Methyl 3,4 ‐dihydroxybenzoate protects against d‐galN/LPS‐induced acute liver injury by inhibiting inflammation and apoptosis in mice
ConclusionsMethyl 3,4 ‐dihydroxybenzoate can effectively resistd‐galN/LPS‐induced acute liver failure, which is related to the inhibition of inflammation and apoptosis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Authors: Xiangpeng Wang, Lulu Wu, Quanshu Zhang, Lili Li, Yanni Xie, Xing Wan, Hao Wu, Yang Xiang Tags: Research Paper Source Type: research

Treatment of atherosclerotic plaque: perspectives on theranostics
AbstractObjectivesAtherosclerosis, a progressive condition characterised by the build ‐up of plaque due to the accumulation of low‐density lipoprotein and fibrous substances in the damaged arteries, is the major underlying pathology of most cardiovascular diseases. Despite the evidence of the efficacy of the present treatments for atherosclerosis, the complex and poorly understoo d underlying mechanisms of atherosclerosis development and progression have prevented them from reaching their full potential. Novel alternative treatments like usage of nanomedicines and theranostics are gaining attention of the researchers w...
Source: Journal of Pharmacy and Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Authors: Yicong Zhang, Aayushi Koradia, Danielle Kamato, Amirali Popat, Peter J. Little, Hang T. Ta Tags: Review Source Type: research

Caucasian endemic medicinal and nutraceutical plants: in ‐vitro antioxidant and cytotoxic activities and bioactive compounds
ConclusionsThis study provides in ‐vitro data relevant for assessing the use of Caucasian endemic medicinal plants, most importantlyC. armena andT. transcaucasicus as traditional antioxidant supplements and potential anticancer remedies. Metabolite profiles of some lead plants showed the nature of bioactive compounds of medical interest. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Authors: Artur Manukyan, Natchagorn Lumlerdkij, Michael Heinrich Tags: Research Paper Source Type: research

Investigation of new treatment option for hepatocellular carcinoma: a combination of sorafenib with usnic acid
ConclusionsConsequently, SOR and UA combination could be a new therapeutic strategy for HCC treatment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Authors: Beste Yurdacan, Unal Egeli, Gamze Guney Eskiler, Isil Ezgi Eryilmaz, Gulsah Cecener, Berrin Tunca Tags: Research Paper Source Type: research

A natural diarylheptanoid protects cortical neurons against oxygen –glucose deprivation‐induced autophagy and apoptosis
ConclusionsThese results demonstrate that AO ‐2 increases resistance of cortical neurons to OGD/R by decreasing autophagy and cell apoptosis, which involves an mTOR‐dependent mechanism. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Authors: Qiaoyun Shi, Qinghua Zhang, Yinghui Peng, Xiaoqi Zhang, Ying Wang, Lei Shi Tags: Research Paper Source Type: research

Alpha ‐linolenic acid ameliorates bronchial asthma features in ovalbumin‐sensitized rats
ConclusionsAlpha ‐linolenic acid suppressed inflammation and oxidative stress, making it a potential therapeutic candidate for treatment of airway inflammatory diseases such as bronchial asthma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Authors: Mohammad Hossein Boskabady, Mahsa Kaveh, Farzaneh Shakeri, Nama Mohammadian Roshan, Ramin Rezaee Tags: Research Paper Source Type: research

Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway
AbstractObjectivesKidney cancer is a highly lethal cancer, of which the most common type is renal cell carcinoma (RCC). The targeted drugs used in treating RCC clinically have a lot of side effects. Therefore, it is urgent to find out effective agents with little toxic effects.MethodsThe antiproliferation effect of chlorogenic acid (CA) was performed using the CCK ‐8 assay. Then, we adopted colony formation assay, Annexin V/PI staining assay and JC‐1 mitochondrial membrane potential assay to explore the mechanism of anticancer effect of CA. We also conducted qPCR and Western blot to determine the pathway involved.Key f...
Source: Journal of Pharmacy and Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Authors: Xiaokang Wang, Jianghong Liu, Zhanxiong Xie, Jiaoyu Rao, Gengrui Xu, Kaiyuan Huang, Wenyan Li, Zijun Yin Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 71, Issue 5, Page i-iv, May 2019. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 12, 2019 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Pitavastatin attenuates cisplatin ‐induced renal injury by targeting MAPK and apoptotic pathways
ConclusionCisplatin ‐induced acute renal injury was improved on administration of pitavastatin via inhibition of MAPK and apoptotic pathway. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 7, 2019 Category: Drugs & Pharmacology Authors: Swati Kaushik, Ameesha Tomar, Susrutha Puthanmadhom Narayanan, Tapas Chandra Nag, Dharamvir Singh Arya, Jagriti Bhatia Tags: RESEARCH PAPER Source Type: research

Raloxifene decreases cell viability and migratory potential in prostate cancer cells (LNCaP) with GPR30/GPER1 involvement
ConclusionsRaloxifene was able to modulate GPER1 in LNCaP prostate tumour cells, decreasing cell viability and their migratory potential. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 28, 2019 Category: Drugs & Pharmacology Authors: Giovanna Cassone Salata, Cristiane Figueiredo Pinho, Andr é T. A. G. Freitas, Ariana Musa Aquino, Luis Antonio Justulin, Leonardo Oliveira Mendes, Bianca F. Gonçalves, Flávia Karina Delella, Wellerson Rodrigo Scarano Tags: Research Paper Source Type: research

Curcumin solid dispersion ‐loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing
ConclusionCSDGs are a promising topical formulation for local treatment of vaginal bacterial infection and improvement of vaginal wound healing. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 18, 2019 Category: Drugs & Pharmacology Authors: Mengmeng Zhang, Bo Zhuang, Gangjun Du, Guang Han, Yiguang Jin Tags: Research Paper Source Type: research

A population pharmacokinetic model of vancomycin for dose individualization based on serum cystatin C as a marker of renal function
ConclusionsA vancomycin PPK model with cystatin C as the renal marker has good stability and predictability. The new proposed dosing regimens were predicted to achieve a good PTA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 14, 2019 Category: Drugs & Pharmacology Authors: Tao ‐tao Liu, Hui‐mei Pang, Li Jing, Wen‐xing Wei, Xiao‐ling Qin, Qing Guo, Hua Lu, Dao‐hai Cheng, Wei‐zhe Jiang Tags: Research Paper Source Type: research

Tanshinone IIA protects against lipopolysaccharide ‐induced lung injury through targeting Sirt1
ConclusionsTanshinone IIA prevents LPS ‐induced secretion of pro‐inflammatory cytokines thus exerts protective effects against acute lung injury, probably via modulation of Sirt1/NF‐κB signalling pathway. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 13, 2019 Category: Drugs & Pharmacology Authors: Minxue Quan, Yanni Lv, Yang Dai, Biying Qi, Longsheng Fu, Xuanying Chen, Yisong Qian Tags: Research Paper Source Type: research

Effect of a new cyclic derivative of GABA, RGPU ‐207, on the functions of cardiac and cerebral mitochondria of stressed animals
ConclusionsTwenty ‐four‐hour immobilization and pain stress activate LPO processes inhibit the activity of the aos enzymes and decrease the functional activity of cardiac and cerebral mitochondria. RGPU‐207 restricts LPO, enhances the antioxidant enzyme activity and improves the mitochondrial respiration. The e fficacy of RGPU‐207 is comparable with phenibut and piracetam. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 12, 2019 Category: Drugs & Pharmacology Authors: Ivan Sergeevich Mokrousov, Valentina Nikolaevna Perfilova, Igor Igorevich Prokofiev, Tamara Alexandrovna Popova, Ekaterina Gennadievna Vodopyanova, Olga Sergeevna Vasil'eva, Ivan Nikolaevich Tyurenkov Tags: Research Paper Source Type: research

Mangiferin attenuates bleomycin ‐induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF‐β1/Smad2/3 pathway
ConclusionsMangiferin attenuates BLM ‐induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF‐β1/Smad2/3 pathway. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 7, 2019 Category: Drugs & Pharmacology Authors: Li Jia, Ping Sun, Hui Gao, Jie Shen, Yuan Gao, Cheng Meng, Shidong Fu, Huijuan Yao, Gong Zhang Tags: Research Paper Source Type: research

Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model
ConclusionsTuberoinfundibular peptide of 39 can be a potent neuroendocrine modulator in treating cognitive impairment induced by CUMS rats by controlling glucocorticoid receptor ‐mediated glutamate/GABA abnormalities in brain. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 5, 2019 Category: Drugs & Pharmacology Authors: Gunasekaran Venkatesh, Veintramuthu Sankar, Muthiah Ramanathan Tags: Research Paper Source Type: research

Synthesis, cytotoxicity and liver targeting of 3 ‐O‐β‐D‐Galactosylated Resveratrol
ConclusionsOn the whole, Gal ‐Res increased cellular uptake to HepG2 cells, bioavailability and liver targeting, providing its future clinical application in the treatment of liver diseases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - March 4, 2019 Category: Drugs & Pharmacology Authors: Jiajia Qian, Liqiong Zha, Beilei Wang, Caiyun Zhang, Lufeng Hong, Weidong Chen Tags: Research Paper Source Type: research