Polygonum multiflorum Radix extract protects human foreskin melanocytes from oxidative stress in vitro and potentiates hair follicle pigmentation ex vivo
ConclusionPolygonum multiflorum Radix extract protects in vitro primary human foreskin melanocytes from the deleterious effects of H2O2‐exposure and improves pigmentation within ex vivo human hair follicles, demonstrating the utility of Polygonum multiflorum Radix extract as a potential active ingredient for the protection of melanocytes against premature death. This data provides in vitro mechanistic evidence consistent with existing in vivo studies for the use of Polygonum multiflorum Radix extract as a strategy for the prevention of oxidative‐stress induced hair greying, in line with traditional Polygonum multifloru...
Source: International Journal of Cosmetic Science - January 21, 2017 Category: Dermatology Authors: Peggy Sextius, Richard Betts, Ishak Benkhalifa, St éphane Commo, Joan Eilstein, Marco Massironi, Ping Wang, Jean‐Francois Michelet, Jie Qiu, Xuezhu Tan, Severine Jeulin Tags: Original Article Source Type: research
Anti ‐diabetic activities of cis‐ and trans‐2,3,5,4'‐tetrahydroxystilbene 2‐O‐β‐glucopyranoside from Polygonum multiflorum
Conclusion: Cis‐THSG can be an enriched bioactive ingredient in PM roots from post‐processing and is significantly more effective against hyperglycemia than trans‐THSG. One of the effective pathways was through inhibition of PEPCK.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - December 31, 2016 Category: Nutrition Authors: Wenping Tang, Shiming Li, Yue Liu, Jia ‐Ching Wu, Min‐Hsiung Pan, Mou‐Tuan Huang, Chi‐Tang Ho Tags: Research Article Source Type: research
Neuroprotective effects of 2,3,5,4 ′-tetrahydoxystilbene-2-O-β-D-glucoside from Polygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells
Conclusions These results indicate that THSG has a marked neuroprotective effect against glutamate-induced hippocampal damage by decreasing ROS production and stabilizing MMP. These findings suggest the potential of THSG as a new therapeutic agent for the treatment of cognitive disorders. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 24, 2016 Category: Drugs & Pharmacology Source Type: research
Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma.
Abstract
The root of Polygonum multiflorum (also called He-Shou-Wu in Chinese) is a common herb and medicinal food in Asia used for its anti-aging properties. Our study investigated the therapeutic potential of an extract of the root of Polygonum multiflorum (PME) in allergic asthma by using a mouse model. Feeding of 0.5 and 1 mg/mouse PME inhibited ovalbumin (OVA)-induced allergic asthma symptoms, including airway inflammation, mucus production, and airway hyper-responsiveness (AHR), in a dose-dependent manner. To discern PME's mechanism of action, we examined the profile and cytokine production of inflam...
Source: The American Journal of Chinese Medicine - December 16, 2016 Category: Complementary Medicine Authors: Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R Tags: Am J Chin Med Source Type: research
Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways Analysis
Chun-Yu Li, Can Tu, Dan Gao, Rui-Lin Wang, Hai-Zhu Zhang, Ming Niu, Rui-Yu Li, Cong-En Zhang, Rui-Sheng Li, Xiao-He Xiao, Mei-Hua Yang, Jia-Bo Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2016 Category: Drugs & Pharmacology Source Type: research
a-Glucosidase inhibitors extracted from the roots of Polygonum multiflorum Thunb.
Abstract
A novel stilbene glucoside, polygonumnolide D (1), and a novel dianthrone glycoside, polygonumnolide E (2), were isolated from a 70% EtOH extract of the dried roots of Polygonum multiflorum Thunb., together with six known compounds (3-8). Their structures were elucidated by 1D and 2D NMR as well as mass spectroscopy data. The isolated compounds were evaluated for their a-glucosidase inhibitory activities in vitro. Compounds 1, 2 and 5 showed the inhibitory activity against a-glucosidase with the IC50 values of 2.4, 2.7 and 0.3 μM, respectively.
PMID: 27889542 [PubMed - as supplied by publ...
Source: Fitoterapia - November 22, 2016 Category: Biochemistry Authors: Yang JB, Tian JY, Dai Z, Ye F, Ma SC, Wang AG Tags: Fitoterapia Source Type: research
Urine metabolomics study on the liver injury in rats induced by raw and processed Polygonum multiflorum integrated with pattern recognition and pathways analysis
Conclusion 16 differentially expressed metabolites were identified to be involved in the RP-induced hepatotoxicity. Vitamin B6 metabolism might be mostly related to the hepatotoxicity induced by RP. This finding may provide a potential therapeutic target or option to treat hepatotoxicity induced by RP. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 26, 2016 Category: Drugs & Pharmacology Source Type: research
Tetrahydroxystilbene Glucoside Inhibits Excessive Autophagy and Improves Microvascular Endothelial Dysfunction in Prehypertensive Spontaneously Hypertensive Rats.
This study aimed to investigate role of autophagy in vascular endothelial dysfunction in prehypertension and hypertension and the underlying mechanisms involved. Furthermore, we sought to determine if and how tetrahydroxystilbene glucoside (TSG), a resveratrol analogue and active ingredient of Polygonum multiflorum Thunb used for its cardiovascular protective properties in traditional Chinese medicine, influences vascular endothelial function. Male spontaneously hypertensive rats (SHRs) aged 4 weeks (young) and 12 weeks (adult) were studied and the vascular function of isolated aorta and mesenteric artery was assessed in v...
Source: The American Journal of Chinese Medicine - October 24, 2016 Category: Complementary Medicine Authors: Dong Q, Xing W, Fu F, Liu Z, Wang J, Liang X, Zhou X, Yang Q, Zhang W, Gao F, Wang S, Zhang H Tags: Am J Chin Med Source Type: research
Effects of Hot Water Extracts from Polygonum multiflorum on Ovariectomy Induced Osteopenia in Mice.
Authors: Hwang YH, Kang KY, Kim JJ, Lee SJ, Son YJ, Paik SH, Yee ST
Abstract
Polygonum multiflorum (PM), a traditional Chinese medicine, is used to treat various diseases including nonalcoholic fatty liver disease and hyperlipidemia. However, the influence of PM on osteoporosis in animals is unclear. The present study investigated the antiosteoporotic effect of PM on bone mass in ovariectomized (OVX) mice and its possible mechanism of action. Twenty-five female C3H/HeN mice were divided into five groups of five mice as follows. Sham-operated control mice received daily oral gavage of an equal volume of wat...
Source: Evidence-based Complementary and Alternative Medicine - October 19, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Systematic Review on Chinese Herbal Medicine Induced Liver Injury.
Conclusions. CHM should be used carefully for hepatotoxicity. Liver injury from CHM is similar to that from conventional medicines in clinical characteristics. Details about causative herbs should be illustrated, and more RUCAM should be used in future.
PMID: 27651817 [PubMed - as supplied by publisher] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine ‐induced liver injury of 1985 patients
ConclusionsThe causal relationship between CHM and liver injury is much complex, and the clinical characteristics of DILI caused by CHM differ from those caused by WM. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 29, 2016 Category: Gastroenterology Authors: Yun Zhu, Ming Niu, Jing Chen, Zheng ‐sheng Zou, Zhi‐jie Ma, Shu‐hong Liu, Rui‐lin Wang, Ting‐ting He, Hai‐bo Song, Zhong‐xia Wang, Shi‐biao Pu, Xiao Ma, Li‐fu Wang, Zhao‐fang Bai, Yan‐ling Zhao, Yong‐gang Li, Jia‐bo Wang, Xiao‐ Tags: Hepatology Source Type: research
Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK/ Nrf2 pathways
Publication date: Available online 19 August 2016 Source:Neurochemistry International Author(s): Sun Young Park, Mei Ling Jin, Seon Yeong Chae, Min Jung Ko, Yung Hyun Choi, Geuntae Park, Young-Whan Choi Polygonum multiflorum extracts are known to improve memory and learning ability, and have neuroprotective and anti-aging activity. However, its function and the underlying mechanisms in neuroinflammation-mediated neurodegenerative disease remain poorly understood. In the present study, we investigated the anti-neuroinflammatory effects of several compounds from P. multiflorum, and found a novel compound, CRPE55IB. ...
Source: Neurochemistry International - August 19, 2016 Category: Neuroscience Source Type: research
Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation.
This study examined whether emodin can activate AMPK/Nrf2 signaling and induce the expression of genes targeted by this pathway. In addition, the anti-neuroinflammatory properties of emodin in lipopolysaccharide (LPS)-stimulated microglia were examined. In microglia, the emodin treatment increased the levels of LKB1, CaMKII, and AMPK phosphorylation. Emodin increased the translocation and transactivity of Nrf2 and enhanced the levels of HO-1 and NQO1. In addition, the emodin-mediated expression of HO-1 and NQO1 was attenuated completely by an AMPK inhibitor (compound C). Moreover, emodin decreased dramatically the LPS-indu...
Source: Neurochemical Research - August 18, 2016 Category: Neuroscience Authors: Park SY, Jin ML, Ko MJ, Park G, Choi YW Tags: Neurochem Res Source Type: research
Chromenone Derivatives from Processed Roots of Polygonum multiflorum
Polygonumoside E (1), a new chromenone derivative, was isolated from processed roots of Polygonum multiflorum along with three known compounds, 2,5-dimethyl-7-hydroxychromenone (2), 2-(2-hydroxylpropyl)-5-methylchromenone-7-O- β-D-glucopyranoside (3), and trycin-7-O- β-D-glucopyranoside (4). Their structures were elucidated by the extensive use of 1D and 2D NMR experiments, together with HR-ESI-MS spectra. Compounds2 –4 were reported from roots of P. multiflorum for the first time. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - August 9, 2016 Category: Chemistry Source Type: research
Arginase Inhibitor 2,3,5,4 ′-Tetrahydroxystilbene-2-O-β-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function
Planta MedDOI: 10.1055/s-0042-111014Endothelial arginase constrains the activity of endothelial nitric oxide synthase by reducing nitric oxide bioavailability, which contributes to vascular diseases. During screening, we identified a novel compound from the rhizome of Polygonum multiflorum (Polygonaceae), 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), which inhibited arginase activity. THSG exhibited noncompetitive inhibition of arginase II and inhibited both arginases I and II in a dose-dependent manner. THSG-dependent arginase inhibition reciprocally increased nitric oxide production and decreased reactive ox...
Source: Planta Medica - July 7, 2016 Category: Drugs & Pharmacology Authors: Yi, Bonggu Nguyen, Minh Cong Won, Moo-Ho Kim, Young Myeong Ryoo, Sungwoo Tags: Original Papers Source Type: research
