Inhibitory effects of 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside on angiotensin II-induced proliferation of vascular smooth muscle cells
Conclusions
TSG inhibited Ang II-induced VSMCs proliferation. Its antiproliferative effect might be associated with down-regulation of intracellular ROS, followed by the suppression of the Src-MEK1/2-ERK1/2 signal pathway, and hence, blocking cell cycle progression. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 1, 2015 Category: Internal Medicine Source Type: research
Causes, Features, and Outcomes of Drug-Induced Liver Injury in 69 Children from China.
Conclusions: Most cases of DILI in children are caused by antibiotics or CHM used to treat respiratory infection and present with hepatocellular injury. Compared with WM, CHM is more likely to cause severe liver injury, but liver injury caused by CHM is curable.
PMID: 25717050 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - February 27, 2015 Category: Gastroenterology Tags: Gut Liver Source Type: research
Emodin induces neurite outgrowth through PI3K/Akt/GSK-3β-mediated signaling pathways in Neuro2a cells
In this study, a neurite outgrowth-inducing substance was isolated from the ethylacetate extract of the Polygonum multiflorum roots and identified as emodin by gas–liquid chromatography–mass spectrometry and 1H NMR and 13C NMR. Emodin displayed remarkable neurite outgrowth-inducing activity in Neuro2a cells, as demonstrated by morphological changes and immunocytochemistry for class III β-tubulin. Emodin exhibited a stronger neutrophic activity than retinoic acid (RA) known as inducer of neurite outgrowth in Neuro2a cells. Emodin treatment resulted in marked increases in phosphorylation of Akt a direct downstream signa...
Source: Neuroscience Letters - January 9, 2015 Category: Neuroscience Source Type: research
Tetrahydroxystilbene Glucoside Improves TNF-α-Induced Endothelial Dysfunction: Involvement of TGFβ/Smad Pathway and Inhibition of Vimentin Expression.
Abstract
Endothelial dysfunction plays an important role in the pathogenesis of atherogenesis. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component of the rhizome extract from Polygonum multiflorum (PM), exhibits significant anti-atherosclerotic activity. Here, we used human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-α (TNF-α) in vitro to investigate the cytoprotective effects of TSG on TNF-α-induced endothelial injury and the related mechanisms. Pretreatment with 50 and 100 μM TSG markedly attenuated TNF-α-induced loss of cell viability and relea...
Source: The American Journal of Chinese Medicine - January 8, 2015 Category: Complementary Medicine Authors: Yao W, Gu C, Shao H, Meng G, Wang H, Jing X, Zhang W Tags: Am J Chin Med Source Type: research
Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review
Conclusion Therapeutic potential of Polygonum multiflorum has been demonstrated in the conditions like Alzheimer׳s disease, Parkinson׳s disease, hyperlipidaemia, inflammation and cancer, which is attributed to the presence of various stilbenes, quinones, flavonoids, phospholipids and other compounds in the drug. On the other hand, the adverse effects (hepatotoxicity, nephrotoxicity, and embryonic toxicity) of this plant were caused by the quinones, such as emodin and rhein. Thus more pharmacological and toxicological mechanisms on main active compounds are necessary to be explored, especially the combined anthraquinones ...
Source: Journal of Ethnopharmacology - November 30, 2014 Category: Drugs & Pharmacology Source Type: research
Emoghrelin, a unique emodin derivative in Heshouwu, stimulates growth hormone secretion via activation of the ghrelin receptor
Conclusion The results suggest that emoghrelin is a key ingredient accounting for the anti-aging effects of Heshouwu, and possesses great potential to be a promising non-peptidyl analog of ghrelin. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 25, 2014 Category: Drugs & Pharmacology Source Type: research
Chemical constituents from the root of Polygonum multiflorum and their soluble epoxide hydrolase inhibitory activity.
Abstract
Fourteen compounds were isolated from a methanol extract of Polygonum multiflorum roots, and their structures were elucidated by comparing spectroscopic data to published spectra. The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were then evaluated. Compounds 1-7 inhibited sEH activity potently, with IC50 values ranging from 6.2 ± 0.5 to 48.6 ± 3.1 μM. Moreover, a kinetic analysis of compounds 1-7 revealed that the inhibitory actions of compounds 1, 3 and 4 were non-competitive, whereas those of compounds 2 and 5-7 were mixed-type.
PMID: 25413971 ...
Source: Archives of Pharmacal Research - November 21, 2014 Category: Drugs & Pharmacology Authors: Sun YN, Li W, Kim JH, Yan XT, Kim JE, Yang SY, Kim YH Tags: Arch Pharm Res Source Type: research
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions.
Abstract
Abstract 1. To investigate the effects of tetrahydroxystilbene glucoside (TSG), the main active component of Polygonum multiflorum, on mouse liver cytochrome P450 (Cyp) enzyme protein expressions. Male mice were randomly divided into the control, TSG low (10 mg/kg) and high dose (40 mg/kg) groups. After TSG intragastrical administration for 3, 5 and 7 d, mice were sacrificed and the mouse body and liver weight were detected. The Cyp enzymes and various transcription factors such as AhR, PXR and PPARα protein expressions in mouse livers were measured by Western blotting assay. 2. No significan...
Source: Xenobiotica - October 28, 2014 Category: Research Authors: Wang YY, Yang J, Liu H, Lin FQ, Shi JS, Zhang F Tags: Xenobiotica Source Type: research
Thinning of dermas with the increasing age may be against by tetrahydroxystilbene glucoside in mice.
CONCLUSION: TSG and PME showed their protections to skin aging in mice challenged with control groups. It ensured the anti-thinning effect of dermas of TSG and provided two potential factors (insulin/IGF-1 signal pathway and the level of Ca(2+)) related to skin senescence of aging mice.
PMID: 25232382 [PubMed] (Source: exp Mol Med)
Source: exp Mol Med - September 23, 2014 Category: Molecular Biology Authors: Zhou X, Ge L, Yang Q, Xie Y, Sun J, Cao W, Wang S Tags: Int J Clin Exp Med Source Type: research
CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum.
The objective of this study was to evaluate the genotype and allelic frequencies of CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined the clinical mechanism of acute liver injury induced by P. multiflorum. According to the diagnostic criteria for drug-induced liver injury (DILI), 43 cases of P. multiflorum-induced liver injury admitted to the First Affiliated Hospital, Zhejiang University were identified between January 2008 and December 2012. An additional 43 control subjects were also chosen. Several alleles, including *1C, *1F, *2, *7, *9, and *11 of CYP1A2 were amplified f...
Source: Genetics and Molecular Research - August 16, 2014 Category: Genetics & Stem Cells Authors: Ma KF, Zhang XG, Jia HY Tags: Genet Mol Res Source Type: research
Emodin inhibits tonic tension through suppressing PKCδ‐mediated inhibition of myosin phosphatase in isolated rat thoracic aorta
Conclusion and implicationsTaken together, we demonstrated that emodin attenuates tonic tension through the blockade of PKCδ and CPI‐17 mediated MLC‐phosphatase inhibition. This new mode of action for the suppression of tonic tension and a structural insight for PKCδ inhibition given by emodin may provide a new insight for the development of modulators of tonic tension and hypertensive diseases. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - June 9, 2014 Category: Drugs & Pharmacology Authors: Kyung‐Min Lim, Jae‐Hyuk Kwon, Keunyoung Kim, Ji‐Yoon Noh, Seojin Kang, Jung‐Min Park, Moo‐Yeol Lee, Ok‐Nam Bae, Jin‐Ho Chung Tags: Research Paper Source Type: research
Review article: herbal hepatotoxicity – an update on traditional Chinese medicine preparations
ConclusionStringent evaluation of the risk/benefit ratio is essential to protect traditional Chinese medicines users from health hazards including liver injury. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - May 20, 2014 Category: Drugs & Pharmacology Authors: R. Teschke, A. Wolff, C. Frenzel, J. Schulze Tags: Review Article Source Type: research
Eighteen cases of liver injury following ingestion of Polygonum multiflorum.
CONCLUSIONS: P. multiflorum products can be associated with hepatotoxicity in otherwise healthy non-viral hepatitis infected patients, regardless of herbal processing.
PMID: 24559819 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - February 1, 2014 Category: Complementary Medicine Authors: Dong H, Slain D, Cheng J, Ma W, Liang W Tags: Complement Ther Med Source Type: research
An in vitro study of neuroprotective properties of traditional Chinese herbal medicines thought to promote healthy ageing and longevity
Conclusions:
This in vitro study provides evidence for neuroprotective activity of some Chinese herbal medicines traditionally used to promote healthy ageing and longevity. Our results provide a justification for further study of these herbal extracts in neurodegenerative animal models to assess their safety and effectiveness as a basis for subsequent clinical trials. These herbal medicines might potentially offer a novel preemptive neuroprotective approach in neurodegenerative diseases and might be developed for use in persons at risk. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - December 27, 2013 Category: Complementary Medicine Authors: Bojiang ShenJohn TruongRay HelliwellSuresh GovindaraghavanNikolaus Sucher Source Type: research
2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro
Conclusions: Our study indicates that THSG has potent anti-platelet activity to collagen induced aggregation. THSG is likely to exert protective effects in platelet-associated thromboembolic disorders by modulating human platelet. (Source: Thrombosis Research)
Source: Thrombosis Research - December 16, 2013 Category: Hematology Authors: Ke Xiang, Gang Liu, Ya-Jun Zhou, Hong-Zhen Hao, Zhao Yin, Ao-Di He, Xing-Wen Da, Ji-Zhou Xiang, Jia-Ling Wang, Zhang-Yin Ming Tags: Platelets and cell biology Source Type: research
