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Acupuncture suppresses intravenous methamphetamine self-administration through GABA receptor ’s mediation
Conclusions Results of this study have shown that acupuncture at HT7 suppressed methamphetamine self-administration through GABA receptor system, suggesting that acupuncture at HT7 can be a useful therapy for the treatment of methamphetamine abuse. (Source: Neuroscience Letters)
Source: Neuroscience Letters - October 12, 2017 Category: Neuroscience Source Type: research

Arginine vasopressin antagonizes the effects of prostaglandin E2 on the spontaneous activity of warm-sensitive and temperature-insensitive neurons in the medial preoptic area in rats
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Jian-Hui Xu, Xiao-Yu Hou, Yu Tang, Rong Luo, Jie Zhang, Chang Liu, Yong-Lu Yang Arginine vasopressin (AVP) plays an important role in thermoregulation and antipyresis. We have demonstrated that AVP could change the spontaneous activity of thermosensitive and temperature insensitive neurons in the preoptic area. However, whether AVP influences the effects of prostaglandin E2 (PGE2) on the spontaneous activity of neurons in the medial preoptic area (MPO) remains unclear. Our experiment showed that PGE2 decreased the spontaneous activity of w...
Source: Neuroscience Letters - October 12, 2017 Category: Neuroscience Source Type: research

Integrated microarray analysis provided a new insight of the pathogenesis of Parkinson ’s disease
Conclusions Several DEGs including SNCA, COX17, COX4I1, COX7B, COX6A1 and ATP5J targeted by Pax-4, Oct-1 and Evi-1 may involve in the neurodegeneration and pathogenesis of PD by regulating oxidative phosphorylation, ATP production and oxidative stress, which was benefit for uncovering the mechanism of PD and developing new diagnostic and therapeutic strategies. (Source: Neuroscience Letters)
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Naoki Adachi, Aya Yoshimura, Shuichi Chiba, Shintaro Ogawa, Hiroshi Kunugi Brain-derived neurotrophic factor (BDNF) critically controls the fate and function of the neuronal network and has received much attention as a target of many brain diseases. Dopaminergic system dysfunction has also been implicated in a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor agonist, is used in the treatment of Parkinson’s disease and restless legs syndrome. To investigate the effects of rotigotine on neuronal functions...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Xi Jiang, Qizhi Yan, Fuhe Liu, Changfeng Jing, Lianshu Ding, Lijin Zhang, Cong Pang Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare. Trans-astaxanthin has been shown in our previous studies to exert antidepressant-like effect. This work aimed to investigate the effects of trans-astaxanthin on pain-related depressive-like behaviors in mice and explored the mechanism(s). Chronic constriction injury (CCI) model was used in this research. Chronic pain was evaluated by thermal ...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/ − mice
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Nadia Lybøl von Schoubye, Kristen Frederiksen, Uffe Kristiansen, Anders Victor Petersen, Nils Ole Dalby, Morten Grunnet, Henrik Sindal Jensen, Thomas Jespersen, Vikaas S. Sohal, Jean-François Perrier Mental disorders such as schizophrenia are associated with impaired firing properties of fast spiking inhibitory interneurons (FSINs) causing reduced task-evoked gamma-oscillation in prefrontal cortex. The voltage-gated sodium channel NaV1.1 is highly expressed in PV-positive interneurons, but only at low levels in principal cell...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

DNA versus RNA oxidation in Parkinson ’s disease: Which is more important?
Conclusion Oxidative DNA damage plays an important role in the early stages of PD, whereas during the progression of the disease the process is more complex, and other mechanisms are in the foreground. The measurement of 8-OHdG might be used as an “early-stage marker”, whereas the decrease of 8-OHG in CSF might reflect the degree of neurodegeneration during the disease progression, suggesting its utility as a prognostic marker of advanced PD stages. (Source: Neuroscience Letters)
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

Comparative connectomics: Mapping the inter-individual variability of connections within the regions of the human brain
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Csaba Kerepesi, Balázs Szalkai, Bálint Varga, Vince Grolmusz The human braingraph, or connectome is a description of the connections of the brain: the nodes of the graph correspond to small areas of the gray matter, and two nodes are connected by an edge if a diffusion MRI-based workflow finds fibers between those brain areas. We have constructed 1015-vertex graphs from the diffusion MRI brain images of 392 human subjects and compared the individual graphs with respect to several different areas of the brain. The inter-indivi...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

Effects of transcranial direct current stimulation on time limit and ratings of perceived exertion in physically active women
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Eduardo Lattari, Bruno Soares de Oliveira, Bruno Ribeiro Ramalho Oliveira, Rodrigo Cunha de Mello Pedreiro, Sérgio Machado, Geraldo Albuquerque Maranhão Neto The limiting factors of maximum performance in humans have been extensively investigated. The aim of this study was to verify the acute effects of transcranial direct current stimulation on time limit (i.e., the time by which an individual is able to sustain a certain intensity of effort) at 100% of peak power (tlim@100%PP) and ratings of perceived exertion (RPE). Eleven...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

The anti-apoptotic effect of fluid mechanics preconditioning by cells membrane and mitochondria in rats brain microvascular endothelial cells
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Shan Tian, Fengping Zhu, Ruiping Hu, Song Tian, Xingxing Chen, Dan Lou, Bing Cao, Qiulei Chen, Bai Li, Fang Li, Yulong Bai, Yi Wu, Yulian Zhu Exercise preconditioning is a simple and effective way to prevent ischemia. This paper further provided the mechanism in hemodynamic aspects at the cellular level. To study the anti-apoptotic effects of fluid mechanics preconditioning, Cultured rats brain microvascular endothelial cells were given fluid intervention in a parallel plate flow chamber before oxygen glucose deprivation. It showed that fl...
Source: Neuroscience Letters - October 11, 2017 Category: Neuroscience Source Type: research

Subsequent maternal separation exacerbates neurobehavioral abnormalities in rats neonatally exposed to sevoflurane anesthesia
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Jiaojiao Yang, Lingsha Ju, Min Jia, Hui Zhang, Xiaoru Sun, Muhuo Ji, Jianjun Yang, Anatoly E. Martynyuk Several recent studies suggest that in the human population, a routine, short anesthetic in otherwise healthy infants is void of neurodevelopmental insult. On the other hand, many human retrospective epidemiological studies report evidence of cognitive abnormalities in children after testing those who had different anesthesia-requiring procedures in early childhood. We tested in a rat model whether post-anesthesia stressful environment...
Source: Neuroscience Letters - October 10, 2017 Category: Neuroscience Source Type: research

Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK/STAT3 pathway in interleukin 6-treated PC-12 cells
Publication date: 1 January 2018 Source:Neuroscience Letters, Volume 662 Author(s): Su-Na Huang, Huai-Zhen Ruan, Mesona Yung-Jin Chen, Gan Zhou, Zhong Ming Qian To understand the potential mechanisms involved in the beneficial effects of aspirin (ASA) in mood disorders, Alzheimer's (AD) and Parkinson’s disease (PD), we investigated the effects of ASA on the expression of iron transport proteins transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1), and iron storage protein ferritin light chain (Ft-L) in interleukin-6 (IL-6)-treated PC-12 cells. We demonstrated that IL-6 alone could induce a severe decline in Fpn1 expr...
Source: Neuroscience Letters - October 10, 2017 Category: Neuroscience Source Type: research

Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Goun Je, Yoon-Seong Kim Dysregulation of human alpha-synuclein (α-SYN) is one of the major contributors in the pathogenesis of Parkinson’s disease. 1-methyl-4-phenylpyridinium (MPP+) is well known neurotoxin which increases α-SYN expression and causes dopaminergic neuronal death. Increasing evidence suggests microRNAs (miRNAs), especially miRNA-7 and miR-153, have important role in the regulation of α-SYN translation and they can prevent MPP+-mediated neuronal death. Here, we examined whether MPP+-mediated upregul...
Source: Neuroscience Letters - October 8, 2017 Category: Neuroscience Source Type: research

Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke
Conclusions Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema. These findings suggest that HuR could be a therapeutic target in cerebral ischemia/reperfusion. (Source: Neuroscience Letters)
Source: Neuroscience Letters - October 7, 2017 Category: Neuroscience Source Type: research

CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Kaori Yagishita, Ritsuko Suzuki, Shota Mizuno, Ritsuko Katoh-Semba, Tetsushi Sadakata, Yoshitake Sano, Teiichi Furuichi, Yo Shinoda Hippocampal adult neurogenesis is observed in the subgranular zone of the dentate gyrus (DG), and is associated with hippocampal memory formation and several psychiatric disorders including autism spectrum disorder (ASD). Calcium-dependent activator protein for secretion 2 (CAPS2) is a candidate gene related to ASD, and is highly expressed in the hippocampal DG region, with Caps2 knockout (KO) mice exhibitin...
Source: Neuroscience Letters - October 6, 2017 Category: Neuroscience Source Type: research

Prion-like transmission of α-synuclein pathology in the context of an NFL null background
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Nicola J. Rutherford, Mieu Brooks, Cara J. Riffe, Kimberly-Marie M. Gorion, Jasie K. Howard, Jess-Karan S. Dhillon, Benoit I. Giasson Neurofilaments are a major component of the axonal cytoskeleton in neurons and have been implicated in a number of neurodegenerative diseases due to their presence within characteristic pathological inclusions. Their contributions to these diseases are not yet fully understood, but previous studies investigated the effects of ablating the obligate subunit of neurofilaments, low molecular mass neurofilament...
Source: Neuroscience Letters - October 6, 2017 Category: Neuroscience Source Type: research

Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Anna K. Engstrom, Zhengui Xia Lead is a neurotoxicant of immense public health importance. Epidemiology studies suggest that heavy metal exposure may be associated with an increased risk of cognitive decline, yet few studies to date have assessed the effect of adult lead exposure on cognitive behavior in animal models. Here, we exposed 6-week-old male C57BL/6 mice to 0.2% lead acetate via drinking water for 12 weeks starting at 6 weeks of age and then assessed for deficits in hippocampus-dependent spatial memory and impairment of adult h...
Source: Neuroscience Letters - October 6, 2017 Category: Neuroscience Source Type: research

Hypoxia stimulates proliferation of rat neural stem/progenitor cells by regulating mir-21: an in vitro study
In this study, we found that cell proliferation is promoted by hypoxia, and accompanied by increasing expression of miR-21 in cultured rat NSPCs. Moreover, qRT-PCR analysis indicated that expression of miR-21 increases in a time-dependent manner. 5-Bromo-2-deoxyUridine (BrdU) staining and flow cytometry showed that overexpression of miR-21 further promoted proliferation of NSPCs in the presence of hypoxia. Knocking down of miR-21 partially abolished the proliferative effect of hypoxia treatment on cell proliferation. Western blot demonstrated that overexpression of miR-21 enhanced expression of cyclin D1, while knock down ...
Source: Neuroscience Letters - October 3, 2017 Category: Neuroscience Source Type: research

The cytoplasmic nuclear shuttling of Beclin 1 in neurons with Alzheimer ’s disease-like injury
In this study, we investigated the distribution of Beclin 1 fragments in neurons with AD-like injury. Our results demonstrated that Beclin 1 was expressed in neurons but not in astrocytes in both neuron-glia co-cultures and in cortical tissue slices. The full length and C-terminal fragments of human Beclin 1 was mainly expressed in cytoplasm, while the N-terminal fragment of Beclin 1 was predominantly localized in nucleus. Compared to amyloid-β (Aβ)42-1 treatment control, exposure of PC12 cells or cortical neurons to Aβ1-42 resulted in cell injury, with the appearance of neuritic shortening, reduced nuclear ...
Source: Neuroscience Letters - October 2, 2017 Category: Neuroscience Source Type: research

MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer ’s disease
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Xiaohui Ma, Linlin Liu, Jing Meng Alzheimer’s disease (AD) is considered as one of the most common neural degenerative diseases in human. Although the continuous investigations about AD have been made in recent decades, the pathogenesis of this disease is still not definitely confirmed. MicroRNA-125b (miR-125b) is extensive expressed in many types of human tissues and played pivotal regulatory roles in diverse biological process. In the present study, we aimed to explore the roles of miR-125b in regulating neurons cell apoptosis un...
Source: Neuroscience Letters - September 30, 2017 Category: Neuroscience Source Type: research

miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis
In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expression of Bcl-2 decreased. Increasing the amount of a miR-34a mimetic in a mouse auditory cell line (HEI-OC1) inhibited Bcl-2, leading to enhanced apoptosis; in contrast, miR-34a inhibition produced the opposite effect. Our results support a link between age-related cochlear hair cell apoptosis and miR-34a/Bcl-2 signaling. The latter may thus serve as a potential target for AHL therapy. (Source...
Source: Neuroscience Letters - September 29, 2017 Category: Neuroscience Source Type: research

Corrigendum to “KCa1.1 is potential marker for distinguishing Ah-type baroreceptor neurons in NTS and contributes to sex-specific presynaptic neurotransmission in baroreflex afferent pathway” [Neurosci. Lett. 604 (2015) 1–6]
Publication date: 17 October 2017 Source:Neuroscience Letters, Volume 659 Author(s): Yu-Yao Zhang, Zhen-Yu Yan, Mei-Yu Qu, Xin-Jing Guo, Guo Li, Xiao-Long Lu, Yang Liu, Tao Ban, Hong-Li Sun, Guo-Fen Qiao, Bai-Yan Li (Source: Neuroscience Letters)
Source: Neuroscience Letters - September 28, 2017 Category: Neuroscience Source Type: research

Impact of morphine on the expression of insulin receptor and protein levels of insulin/IGFs in rat neural stem cells
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Sadegh Salarinasab, AliReza Nourazarian, Masoud Nikanfar, Nima Abdyazdani, Masoumeh Kazemi, Navid Feizy, Reza Rahbarghazi Alzheimer's disease is correlated with neuronal degeneration and loss of neuronal precursors in different parts of the brain. It has been found disturbance in the homeostasis neural stem cells (NSCs) can cause neurodegeneration. Morphine, an analgesic agent, can disrupt the dynamic and normal state of NSCs. However, more investigations are required to clearly address underlying mechanisms. The current experiment aimed ...
Source: Neuroscience Letters - September 28, 2017 Category: Neuroscience Source Type: research

Polymorphism of the SNAP25 gene is associated with symptom improvement in schizophrenic patients treated with amisulpride
This study enrolled 154 schizophrenic patients from six university hospitals in South Korea. All patients were assessed with the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S) scale at baseline and week 6 of treatment. Additionally, 101 subjects were genotyped for the rs8636 and rs3746544 single nucleotide polymorphisms (SNPs) of SNAP25. The genotype frequencies of rs8636 SNP significantly differed between responders and non-responders, measured by PANSS total score, in additive, recessive, and overdominant models. These findings suggest that SNAP25 might be a useful marker...
Source: Neuroscience Letters - September 28, 2017 Category: Neuroscience Source Type: research

Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Tao Chen, Jie Zhu, Li-Kun Yang, Yi Feng, Wei Lin, Yu-Hai Wang Arc/Arg3.1 is a unique immediate early gene whose expression is highly dynamic and correlated with various forms of synaptic plasticity. Many previous reports highlight the complexity of mechanisms that regulate Arc/Arg3.1 expression in neurons. In the present study, the expression and regulation of Arc/Arg3.1 after glutamate treatment in primary cultured cortical neurons were investigated. We found that both Arc/Arg3.1 mRNA and Arc/Arg3.1 protein dynamically increased within ...
Source: Neuroscience Letters - September 28, 2017 Category: Neuroscience Source Type: research

Elderly adults show higher ventral striatal activation in response to motor performance related rewards than young adults
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Mario Widmer, Samara Stulz, Andreas R. Luft, Kai Lutz Feedback on motor performance activates the striatum and boosting ventral striatum activation with rewarding feedback during motor training supports the consolidation of the learned skill. Aging is associated with changes of the reward system, including striatal and extrastriatal loss of dopamine receptors. How these changes interact with the blood oxygenation level dependent (BOLD) response is, however, not yet fully understood. While it is known that reward prediction and reward-bas...
Source: Neuroscience Letters - September 27, 2017 Category: Neuroscience Source Type: research

Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Ryan K. Butler, Sarah Ehling, Megan Barbar, Jess Thomas, Mary A. Hughes, Charles E. Smith, Vladimir M. Pogorelov, Dipendra K. Aryal, William C. Wetsel, B. Duncan X. Lascelles Fear-conditioned analgesia (FCA) is modulated by brain areas involved in the descending inhibitory pain pathway such as the basolateral (BLA) and central amygdala (CEA). The BLA contains Ca2+/calmodulin-dependent protein kinase II (CaMKII) and parvalbumin (PV) neurons. CEA neurons are primarily inhibitory (GABAergic) that comprise enkephalin (ENK) interneurons and c...
Source: Neuroscience Letters - September 25, 2017 Category: Neuroscience Source Type: research

Investigation into the role of an extracellular loop in mediating proton-evoked inhibition of voltage-gated sodium channels
Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Elisa Harms, Carsten Stoetzer, Thomas Stueber, Andrias O. O’Reilly, Andreas Leffler Proton-evoked activation of sensory neurons is counteracted by inhibition of voltage-gated Na+ channels, and the low acid-sensitivity of sensory neuron of the African naked mole-rat (ANMr) was reported to be due to a strong proton-evoked block of ANMrNav1.7. Here we aimed to reevaluate the role of the suggested negatively-charged motif in the ANMrNav1.7 domain IV P-loop for inhibition by protons. Patch clamp recordings were performed on the recombin...
Source: Neuroscience Letters - September 25, 2017 Category: Neuroscience Source Type: research

The histone deacetylase inhibitor sodium butyrate protects against noise-induced hearing loss in Guinea pigs
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Deng-Hua Yang, Jing Xie, Ke Liu, Zhe Peng, Jing-Ying Guo, Shu-Kui Yu, Guo-Peng Wang, Shu-Sheng Gong Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals. Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although histone deacetylase (HDAC) inhibitors were shown to protect against NIHL, the underlying mechanism remains unclear, and it is not known how they act on noise-induced oxidative stress. In the current study, we investigated the expression levels of acetyl-histon...
Source: Neuroscience Letters - September 23, 2017 Category: Neuroscience Source Type: research

Roles of N-methyl-d-aspartate receptors during the sensory stimulation-evoked field potential responses in mouse cerebellar cortical molecular layer
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Yin-Hua Xu, Guang-Jian Zhang, Jing-Tong Zhao, Chun-Ping Chu, Yu-Zi Li, De-Lai Qiu The functions of N-methyl-d-aspartate receptors (NMDARs) in cerebellar cortex have been widely studied under in vitro condition, but their roles during the sensory stimulation-evoked responses in the cerebellar cortical molecular layer in living animals are currently unclear. We here investigated the roles of NMDARs during the air-puff stimulation on ipsilateral whisker pad-evoked field potential responses in cerebellar cortical molecular layer in urethane-a...
Source: Neuroscience Letters - September 22, 2017 Category: Neuroscience Source Type: research

Gaze position interferes in body sway in young adults
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Carolina Menezes Fiorelli, Paula Fávaro Polastri, Sérgio Tosi Rodrigues, André Macari Baptista, Tiago Penedo, Vinicius Alota Ignácio Pereira, Lucas Simieli, Fabio Augusto Barbieri Postural control is influenced by eye movements. Gaze fixation, which comprises a component of ocular vergence, is important in the acquisition of highly specific task information, but its relation to postural control is little investigated. The aim of the study was to investigate the effects of gaze fixation position (central and lat...
Source: Neuroscience Letters - September 22, 2017 Category: Neuroscience Source Type: research

Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargahi Insulin, as a peptide hormone, has recently gained attention for its pro-cognitive, anti-inflammatory and neuroprotective effects in the central nervous system (CNS). Most studies have indicated anxiogenic and neuroinflammatory effects of methamphetamine (MA) and other psychostimulants, even after periods of abstinence. The present study aimed to examine whether intranasal (IN) insulin treatment with high CNS bioavailability and ...
Source: Neuroscience Letters - September 22, 2017 Category: Neuroscience Source Type: research

Neural representation of cost-benefit selections in medial prefrontal cortex of rats
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Hua Tang, Xuan Sun, Bao-Ming Li, Fei Luo Decision making refers to the process that subjects use to choose between competing courses of action based on the expected costs and benefits of their consequences. However, few studies have addressed the neuronal mechanisms behind the processes of how costs and benefits influence decision making. Here we investigated the neuronal representation of costs and benefits towards a goal-directed action under a differential reward schedule by training rats to perform a “Do more, get more” (D...
Source: Neuroscience Letters - September 22, 2017 Category: Neuroscience Source Type: research

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Dominik Feuerbach, Patrick Schindler, Carmen Barske, Stefanie Joller, Edwige Beng-Louka, Katie A. Worringer, Sravya Kommineni, Ajamete Kaykas, Daniel J. Ho, Chaoyang Ye, Karl Welzenbach, Gaelle Elain, Laurent Klein, Irena Brzak, Anis K. Mir, Christopher J. Farady, Reiner Aichholz, Simone Popp, Nathalie George, Ulf Neumann Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regul...
Source: Neuroscience Letters - September 21, 2017 Category: Neuroscience Source Type: research

Neuroprotective effect of curcumin-I in copper-induced dopaminergic neurotoxicity in rats: A possible link with Parkinson ’s disease
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Abdellatif Abbaoui, Hicham Chatoui, Omar El Hiba, Halima Gamrani Numerous findings indicate an involvement of heavy metals in the neuropathology of several neurodegenerative disorders, especially Parkinson’s disease (PD). Previous studies have demonstrated that Copper (Cu) exhibits a potent neurotoxic effect on dopaminergic neurons and triggers profound neurobehavioral alterations. Curcumin is a major component of Curcuma longa rhizomes and a powerful medicinal plant that exerts many pharmacological effects. However, the neuroprotec...
Source: Neuroscience Letters - September 21, 2017 Category: Neuroscience Source Type: research

SEN1500, a novel oral amyloid- β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease
Discussion SEN1500 is not only able to reduce Aβ pathology and activated microglia but also to improve learning and memory as previously shown, making SEN1500 a potential candidate for human AD treatment. This Aβ aggregation inhibitor could be a promising therapeutic agent for the disease-modifying treatment of AD. (Source: Neuroscience Letters)
Source: Neuroscience Letters - September 21, 2017 Category: Neuroscience Source Type: research

Neuroprotective effect of 5 ɑ-androst-3β,5,6β-triol on retinal ganglion cells in a rat chronic ocular hypertension model
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Yan-Qiu Chen, Shu-Min Zhong, Shu-Ting Liu, Feng Gao, Fang Li, Yuan Zhao, Xing-Huai Sun, Yanying Miao, Zhongfeng Wang Previous studies have demonstrated that 5ɑ-androst-3β,5,6β-triol (Triol), a synthesized steroid compound, showed notable neuroprotective effect in cultured cortical neurons. In the present study, we explored whether and how Triol have neuroprotective effect on retinal ganglion cells (RGCs) in a chronic ocular hypertension (COH) rat model. COH model was produced by injecting superparamagnetic iron oxide micro-bead...
Source: Neuroscience Letters - September 21, 2017 Category: Neuroscience Source Type: research

The interplay between ventro striatal BDNF levels and the effects of valproic acid on the acquisition of ethanol-induced conditioned place preference in mice
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Manuel Alves dos Santos, Sarah Sousa Escudeiro, Germana Silva Vasconcelos, Natália Castelo Branco Matos, Marcos Romário Matos de Souza, Manoel Cláudio Azevedo Patrocínio, Leonardo Pimentel Dantas, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos Alcohol addiction is a chronic, relapsing and progressive brain disease with serious consequences for health. Compulsive use of alcohol is associated with the capacity to change brain structures involved with the reward pathway, such as ventral striatum. R...
Source: Neuroscience Letters - September 20, 2017 Category: Neuroscience Source Type: research

Non-canonical Wnt mediated neurogenic differentiation of human bone marrow-derived mesenchymal stem cells
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Sujeong Jang, Hyong-Ho Cho, Jong-Seong Park, Han-Seong Jeong Bone marrow-derived mesenchymal stem cells (BM-MSCs), which are characterized by multipotency and self-renewal, are responsible for tissue regeneration and repair. We have previously reported in adipose tissue-derived MSCs that only Wnt5a is enhanced at neurogenic differentiation, and the mechanism of differentiation is dependent on the Wnt5a/JNK pathway; however, the role of Wnt/MAPK pathway is yet to be investigated in neurogenic differentiation in BM-MSCs. We compared the tra...
Source: Neuroscience Letters - September 19, 2017 Category: Neuroscience Source Type: research

Evaluation of the Braak staging of brain pathology with 1H-MRS in patients with Parkinson ’s disease
In this study, we investigated the metabolites of medulla oblongata, substantia nigra (SN), putamen, and motor cortex by measuring N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine (Cr) in 22 patients of PD and 15 age-matched healthy controls, using single-voxel 1H-magnetic resonance spectroscopy (1H-MRS). The results showed that NAA/Cr in SN was lower in PD group than that in control group (p =0.006), however, there was no difference for NAA/Cr and Cho/Cr between PD group and control group in other regions. In SN, NAA/Cr was negatively correlated with Unified Parkinson’s Disease Rating Scale (...
Source: Neuroscience Letters - September 15, 2017 Category: Neuroscience Source Type: research

Differential expression of ryanodine receptor isoforms after spinal cord injury
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Nicolas Pelisch, Cynthia Gomes, Jacqueline M. Nally, Jeffrey C. Petruska, David P. Stirling Ryanodine receptors (RyRs) are highly conductive intracellular Ca2+ release channels and are widely expressed in many tissues, including the central nervous system. RyRs have been implicated in intracellular Ca2+ overload which can drive secondary damage following traumatic injury to the spinal cord (SCI), but the spatiotemporal expression of the three isoforms of RyRs (RyR1-3) after SCI remains unknown. Here, we analyzed the gene and protein expre...
Source: Neuroscience Letters - September 15, 2017 Category: Neuroscience Source Type: research

Leptin status alters buprenorphine-induced antinociception in obese mice with dysfunctional leptin receptors
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Zachary Glovak, Sara Mihalko, Helen A. Baghdoyan, Ralph Lydic Buprenorphine is an opiate used for pain management and to treat opiate addiction. The cytokine leptin can modulate nociception, but the extent to which buprenorphine-induced antinociception varies as a function of leptin signaling has not been characterized. Four congenic mouse lines with phenotypes that include differences in body weight and leptin status were used to test the hypothesis that the antinociceptive effects of buprenorphine vary as function of sex and leptin sign...
Source: Neuroscience Letters - September 13, 2017 Category: Neuroscience Source Type: research

Resting state fMRI observations of baseline brain functional activities and connectivities in primary blepharospasm
In conclusion, this study indicated that BPS patients have both abnormal intra-regional spontaneous brain activities and inter-regional functional connectivities. (Source: Neuroscience Letters)
Source: Neuroscience Letters - September 13, 2017 Category: Neuroscience Source Type: research

Neurosteroid dehydroepiandrosterone improves active avoidance retrieval and induces antidepressant-like behavior in rats
This study aimed to investigate the behavioral profile of acute DHEA treatment by using active avoidance (AA) task, primarily predictive of the effects on the retrieval-based learning, and by applying forced swim test (FST), for assessment of antidepressant-like potential. Adult male Wistar rats received intraperitoneal injections of either DHEA (2, 10, 20mg/kg) or solvent, 30min prior to testing. DHEA, in a manner resembling an inverted U shape, influenced the retrieval imposed to rats in AA paradigm. The significant improvement of the performance in the retention session was observed following 10mg/kg DHEA treatment and ...
Source: Neuroscience Letters - September 13, 2017 Category: Neuroscience Source Type: research

Orexin receptors mediate long-term depression of excitatory synaptic transmission in the spinal cord dorsal horn
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Ki Bum Park, Haein Weon Neuropeptides orexin-A and -B are related to the regulation of sleep/wakefulness and feeding behaviors. Recently, the peptides have also been shown to yield antinociceptive effects in various pain models. However, it is not clear whether orexins are involved in forms of synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD), the increase and the decrease of synaptic efficacy, respectively. In the present study, we examined whether orexin receptor type 1 (OX1) and 2 (OX2) are involv...
Source: Neuroscience Letters - September 13, 2017 Category: Neuroscience Source Type: research

The effect of badminton training on the ability of same-domain action anticipation for adult novices: Evidence from behavior and ERPs
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Ting Liu, Mengling Shao, Desheng Yin, Yongjie Li, Nan Yang, Ruru Yin, Ying Leng, Hua Jin, Haixiao Hong Many transverse studies have found that athletes can better anticipate the outcome of sequential actions belonging to their domain of motor expertise than non-athletes. However, few studies have causally investigated this issue. Using badminton training as an example, the present study attempted to explore whether sports training affected the same-domain action anticipation ability of adult novices and the related neural mechanisms. To a...
Source: Neuroscience Letters - September 13, 2017 Category: Neuroscience Source Type: research

Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats
Publication date: 1 November 2017 Source:Neuroscience Letters, Volume 660 Author(s): Mirmohammadali Mirramezani Alizamini, Zahra Farzinpour, Somayeh Ezzatpanah, Abbas Haghparast Orexin receptor shave essential role in the induction of reward-related behaviors to several drugs of abuse. In the present study, we investigated the effects of bilateral administration of SB334867, as an orexin-1 receptor antagonist, and TCS OX2 29, as an orexin-2 receptor antagonist, into the nucleus accumbens (NAc) on the acquisition of morphine-induced conditioned place preference (CPP) in the rats. Adult male Wistar rats (n=80; 220–250...
Source: Neuroscience Letters - September 10, 2017 Category: Neuroscience Source Type: research

CpG demethylation in the neurotoxicity of 1-methyl-4-phenylpyridinium might mediate transcriptional up-regulation of α-synuclein in SH-SY5Y cells
Publication date: 17 October 2017 Source:Neuroscience Letters, Volume 659 Author(s): Jian Yang, Zhaofei Yang, Xuan Wang, Min Sun, Yong Wang, Xiaomin Wang The accumulation of α-synuclein is the primary pathological hallmark of Parkinson’s disease (PD). In PD patients, CpG demethylation of intron-1 has been reported to be associated with α-synuclein up-regulation. Environmental factor, for example neurotoxin, is a major etiological risk factor in PD pathogenesis. However, the role of CpG methylation in neurotoxin-induced PD has not been addressed completely yet. To explore CpG methylation associating with ...
Source: Neuroscience Letters - September 9, 2017 Category: Neuroscience Source Type: research

The role of anterior cruciate ligament in the control of posture; possible neural contribution
This study provided evidence that the two components of postural control are differently affected by ACL deficiency, and that the rambling component is influenced by direction of sway. (Source: Neuroscience Letters)
Source: Neuroscience Letters - September 9, 2017 Category: Neuroscience Source Type: research

Endurance exercise improves function in individuals with Parkinson ’s disease: A meta-analysis
In conclusion, this meta-analysis supports integrating endurance exercise training, as defined by ACSM, into treatment of PD. (Source: Neuroscience Letters)
Source: Neuroscience Letters - September 9, 2017 Category: Neuroscience Source Type: research