Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action
In this study, a STZ diabetes rat model feeding with a high-fat diet was used to test the effects of berberine compared with metformin. Oral glucose tolerance and hyperinsulinemic-euglycemic clamp were used for glucose metabolism and insulin resistance. The Morris water maze was used to observe the compound effects on cognitive impairment. Serum and hippocampal [Formula: see text]-amyloid peptide (A[Formula: see text], Tau and phosphorylated Tau protein deposition in the hippocampi were measured. The TUNEL assay was used to detect the neuronal apoptosis, supported by histomorphological changes and transmissional electron m...
Source: The American Journal of Chinese Medicine - June 17, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Jin-Feng Zhang Jun Song Yu Bai Lan Deng Chun-Peng Feng Xin-Yao Xu Hong-Xia Guo Yi Wang Xin Gao Yan Gu Chuan Jin Jun-Fu Zheng Zhong Zhen Hao Su Source Type: research

Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action
In this study, a STZ diabetes rat model feeding with a high-fat diet was used to test the effects of berberine compared with metformin. Oral glucose tolerance and hyperinsulinemic-euglycemic clamp were used for glucose metabolism and insulin resistance. The Morris water maze was used to observe the compound effects on cognitive impairment. Serum and hippocampal [Formula: see text]-amyloid peptide (A[Formula: see text], Tau and phosphorylated Tau protein deposition in the hippocampi were measured. The TUNEL assay was used to detect the neuronal apoptosis, supported by histomorphological changes and transmissional electron m...
Source: The American Journal of Chinese Medicine - June 17, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Jin-Feng Zhang Jun Song Yu Bai Lan Deng Chun-Peng Feng Xin-Yao Xu Hong-Xia Guo Yi Wang Xin Gao Yan Gu Chuan Jin Jun-Fu Zheng Zhong Zhen Hao Su Source Type: research

Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action
In this study, a STZ diabetes rat model feeding with a high-fat diet was used to test the effects of berberine compared with metformin. Oral glucose tolerance and hyperinsulinemic-euglycemic clamp were used for glucose metabolism and insulin resistance. The Morris water maze was used to observe the compound effects on cognitive impairment. Serum and hippocampal [Formula: see text]-amyloid peptide (A[Formula: see text], Tau and phosphorylated Tau protein deposition in the hippocampi were measured. The TUNEL assay was used to detect the neuronal apoptosis, supported by histomorphological changes and transmissional electron m...
Source: The American Journal of Chinese Medicine - June 17, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Jin-Feng Zhang Jun Song Yu Bai Lan Deng Chun-Peng Feng Xin-Yao Xu Hong-Xia Guo Yi Wang Xin Gao Yan Gu Chuan Jin Jun-Fu Zheng Zhong Zhen Hao Su Source Type: research

Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action
In this study, a STZ diabetes rat model feeding with a high-fat diet was used to test the effects of berberine compared with metformin. Oral glucose tolerance and hyperinsulinemic-euglycemic clamp were used for glucose metabolism and insulin resistance. The Morris water maze was used to observe the compound effects on cognitive impairment. Serum and hippocampal [Formula: see text]-amyloid peptide (A[Formula: see text], Tau and phosphorylated Tau protein deposition in the hippocampi were measured. The TUNEL assay was used to detect the neuronal apoptosis, supported by histomorphological changes and transmissional electron m...
Source: The American Journal of Chinese Medicine - June 17, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Jin-Feng Zhang Jun Song Yu Bai Lan Deng Chun-Peng Feng Xin-Yao Xu Hong-Xia Guo Yi Wang Xin Gao Yan Gu Chuan Jin Jun-Fu Zheng Zhong Zhen Hao Su Source Type: research

Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action
In this study, a STZ diabetes rat model feeding with a high-fat diet was used to test the effects of berberine compared with metformin. Oral glucose tolerance and hyperinsulinemic-euglycemic clamp were used for glucose metabolism and insulin resistance. The Morris water maze was used to observe the compound effects on cognitive impairment. Serum and hippocampal [Formula: see text]-amyloid peptide (A[Formula: see text], Tau and phosphorylated Tau protein deposition in the hippocampi were measured. The TUNEL assay was used to detect the neuronal apoptosis, supported by histomorphological changes and transmissional electron m...
Source: The American Journal of Chinese Medicine - June 17, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Jin-Feng Zhang Jun Song Yu Bai Lan Deng Chun-Peng Feng Xin-Yao Xu Hong-Xia Guo Yi Wang Xin Gao Yan Gu Chuan Jin Jun-Fu Zheng Zhong Zhen Hao Su Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
In this study, the osteosarcoma cell lines were exposed to different concentrations of neohesperidin. Cell proliferation and viability were assessed by CCK-8 and colony-formation assays. The role of neohesperidin in cell cycle progression and apoptosis were analyzed by flow cytometry and western blotting. To identify autophagosomes and autolysosomes, we used a tandem GFP-mRFP-LC3B lentiviral construct. In addition, autophagy was evaluated by examining autophagosome formation using transmission electron microscopy. Intracellular reactive oxygen species (ROS) production was detected by fluorescence microscopy and flow cytome...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Shubin Wang Zongguang Li Wei Liu Guojun Wei Naichun Yu Guangrong Ji Source Type: research

Traditional Chinese Medicine Decoctions Significantly Reduce the Mortality in Severe and Critically Ill Patients with COVID-19: A Retrospective Cohort Study
Am J Chin Med. 2021 Jun 5:1-30. doi: 10.1142/S0192415X21500518. Online ahead of print.ABSTRACTCoronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions (TCMDs) have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to address this gap. In this retrospective cohort study, we included inpatients diagnosed with severe/critical COVID-19 at the Tongren Hospital of Wuhan University and grouped them de...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Qin-Guo Sun Xue-Dong An Ping Xie Bo Jiang Jia-Xing Tian Qian Yang Xiu-Yang Li Meng Luo Ping Liu Sheng-Hui Zhao Li-Yun Duan Su-Ping Lang An Fan Peng-Cheng Luo Feng-Mei Lian Xiao-Dong Huang Xiao-Lin Tong Source Type: research

Active Components from Traditional Herbal Medicine for the Potential Therapeutics of Idiopathic Pulmonary Fibrosis: A Systemic Review
Am J Chin Med. 2021 Jun 3:1-22. doi: 10.1142/S0192415X2150052X. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF), a tumor-like disease, is a serious and fatal pulmonary inflammatory condition usually characterized by irreversible destruction of the lung parenchyma, excessive matrix accumulation, and decline in lung function. IPF still remains a great burden to the universe. At the moment, the available therapeutic regimens utilized for IPF such as non-pharmacological therapies (lung transplantation) and pharmacological therapies (drugs, nintedanib, pirfenidone, etc.) are normally accompanied by significant...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Ebuka-Olisaemeka Nwafor Peng Lu Yiting Liu Hui Peng Huan Qin Kuibin Zhang Zhe Ma Bin Xing Yukun Zhang Jiawei Li Zhidong Liu Source Type: research

How Chinese Herbal Medicine Prevents Epidemics: From Ancient Pestilences to COVID-19 Pandemic
Am J Chin Med. 2021 Jun 5:1-28. doi: 10.1142/S0192415X2150049X. Online ahead of print.ABSTRACTThe ongoing coronavirus disease 2019 (COVID-19) pandemic calls for effective control and prevention. Chinese medicine (CM) has developed systematic theories and approaches for infectious disease prevention over 2000 years. Here, we review and analyze Chinese herbal medicines (CHM) used in infectious disease prevention from ancient pestilences to modern epidemics and pandemics to share cumulative preventive medical experience. A total of 829 formulas, including 329 herbs from 189 ancient books, 131 formulas with 152 herbs, and 13 C...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Xia-Qiu Wu Wei-Na Zhang Ming-Zhao Hao Xi-Ping Liu Jing Xiao Teng-Fei Wang Yi-Zhi Dong Jing Zhao Source Type: research

Gut Microbiota and Urine Metabonomics Alterations in Constitution after Chinese Medicine and Lifestyle Intervention
In this study, 60 healthy YAX students selected from a prospective population of 5185 were enrolled in a randomized clinical trial and completed the study. We compared the gut microbiota and urinary metabolome between individuals with PH and those with YAX before and after one-month-intervention. Compared with the control group, the health status of the intervention group improved significantly, the YAX symptom score was reduced, and the efficacy remained high at the one-year follow-up. The gut microbiota of the healthy PH exhibited greater diversity, and significantly higher species were identified.[Formula: see text]Comp...
Source: The American Journal of Chinese Medicine - June 10, 2021 Category: Complementary Medicine Authors: Yuan Jing Shuangshuang Han Jieyu Chen Yigui Lai Jingru Cheng Fei Li Ya Xiao Pingping Jiang Xiaomin Sun Ren Luo Xiaoshan Zhao Yanyan Liu Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway
Am J Chin Med. 2021 May 27:1-19. doi: 10.1142/S0192415X21500580. Online ahead of print.ABSTRACTAlthough ginseng (Panax ginseng C.A. Meyer) has received extensive attention in the treatment and prevention of type 2 diabetes mellitus (T2DM) in the past few decades, there are few studies on the complications of T2DM. At present, obesity-linked diabetic nephropathy (DN) has become the most prevailing element of the end-stage renal failure in the world. The aim of this work is to evaluate the ameliorative effects of ginsenoside Rh1 (G-Rh1) on DN induced by high fat diet plus streptozotocin (HFD/STZ) through some potential and c...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Wen-Ya Su Ying Li Xuan Chen Xin Li Heng Wei Zhi Liu Qiong Shen Chen Chen Ying-Ping Wang Wei Li Source Type: research

Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats
This study investigated the effects of the active ingredients of R. coptidis and ginseng, berberine and ginsenoside Rb1, on depression-like behavior in a rat diabetes model. The animal model was established via a high-fat diet and intraperitoneal injection of streptozotocin, while the animal's depression-like behavior was induced via chronic unpredictable mild stress. These experimental rats were divided into four groups: control, depression-like behavior (DLB), metformin plus fluoxetine hydrochloride (M+FH), and berberine plus ginsenoside Rb1 (B+GRb1) groups. Glucose metabolism and insulin resistance were evaluated by ora...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Hui-Zeng Yang Hao Su Jun Song Yu Bai Lan Deng Chun-Peng Feng Hong-Xia Guo Yi Wang Xin Gao Yan Gu Zhong Zhen Yao Lu Source Type: research

Efficacy of Acupuncture for Insomnia: A Systematic Review and Meta-Analysis
Am J Chin Med. 2021 May 27:1-16. doi: 10.1142/S0192415X21500543. Online ahead of print.ABSTRACTPatients with insomnia frequently use acupuncture as an alternative treatment to pharmacotherapy globally. The aim of this paper is to assess the effect of acupuncture on insomnia. Seven medical databases, including MEDLINE, EMBASE, CENTRAL, CNKI, RISS, NDSL, and OASIS, were used to identify studies published through July 09, 2020. Twenty-four randomized controlled trials (RCTs) were included in this qualitative review comparing acupuncture to either pharmacotherapy or sham-acupuncture therapy. Methodological quality was assessed...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Sung-A Kim Sook-Hyun Lee Jang-Hoon Kim Maurits van den Noort Peggy Bosch Tiana Won Sujung Yeo Sabina Lim Source Type: research

Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine
Am J Chin Med. 2021 May 27:1-19. doi: 10.1142/S0192415X21500531. Online ahead of print.ABSTRACTTraditional Chinese medicine (TCM) is a systematic medicine. It provides alternative strategies for the treatment of depression with its clinical experience, comprehensive diagnosis, and treatment theory. Chinese herbal medicine (CHM) is the major form of TCM prescription, and numerous CHMs have been demonstrated to possess remarkable antidepressant-like properties. A diversity of mechanisms have been implicated in CHM-associated antidepressant property. This paper reviewed the neuroplastic mechanisms underlying the antidepressan...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Baomei Xia Chang Chen Weiwei Tao Source Type: research

Effects of Stimulating Local and Distal Acupoints on Diabetic Gastroparesis: A New Insight in Revealing Acupuncture Therapeutics
In this study, diabetic gastroparesis rats were treated by needling Zhongwan (CV12) and Zusanli (ST36), and then used Single Photon Emission Computed Tomography-CT (SPECT-CT) technology to assess the effects of promoting gastric motility. In addition, morphological observation, immunohistochemical examination, and biomarker assays, such as determination of growth factor 1, motilin, and ghrelin contents in serum samples, were performed to better understand the impact of certain various acupuncture treatments. All of the therapies improved the symptoms of diabetic gastroparesis rats, according to the findings. Stimulating th...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bo Yu Mengmeng Sun Zhihong Wang Bing Zhu Jingquan Xue Wenjiang Yang Xinyan Gao Mujun Zhi Jiazhen Cao Jinying Zhao Xuewei Zhao Wu Liu Fuchun Wang Tie Li Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway
Am J Chin Med. 2021 May 27:1-19. doi: 10.1142/S0192415X21500580. Online ahead of print.ABSTRACTAlthough ginseng (Panax ginseng C.A. Meyer) has received extensive attention in the treatment and prevention of type 2 diabetes mellitus (T2DM) in the past few decades, there are few studies on the complications of T2DM. At present, obesity-linked diabetic nephropathy (DN) has become the most prevailing element of the end-stage renal failure in the world. The aim of this work is to evaluate the ameliorative effects of ginsenoside Rh1 (G-Rh1) on DN induced by high fat diet plus streptozotocin (HFD/STZ) through some potential and c...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Wen-Ya Su Ying Li Xuan Chen Xin Li Heng Wei Zhi Liu Qiong Shen Chen Chen Ying-Ping Wang Wei Li Source Type: research

Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats
This study investigated the effects of the active ingredients of R. coptidis and ginseng, berberine and ginsenoside Rb1, on depression-like behavior in a rat diabetes model. The animal model was established via a high-fat diet and intraperitoneal injection of streptozotocin, while the animal's depression-like behavior was induced via chronic unpredictable mild stress. These experimental rats were divided into four groups: control, depression-like behavior (DLB), metformin plus fluoxetine hydrochloride (M+FH), and berberine plus ginsenoside Rb1 (B+GRb1) groups. Glucose metabolism and insulin resistance were evaluated by ora...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Hui-Zeng Yang Hao Su Jun Song Yu Bai Lan Deng Chun-Peng Feng Hong-Xia Guo Yi Wang Xin Gao Yan Gu Zhong Zhen Yao Lu Source Type: research

Efficacy of Acupuncture for Insomnia: A Systematic Review and Meta-Analysis
Am J Chin Med. 2021 May 27:1-16. doi: 10.1142/S0192415X21500543. Online ahead of print.ABSTRACTPatients with insomnia frequently use acupuncture as an alternative treatment to pharmacotherapy globally. The aim of this paper is to assess the effect of acupuncture on insomnia. Seven medical databases, including MEDLINE, EMBASE, CENTRAL, CNKI, RISS, NDSL, and OASIS, were used to identify studies published through July 09, 2020. Twenty-four randomized controlled trials (RCTs) were included in this qualitative review comparing acupuncture to either pharmacotherapy or sham-acupuncture therapy. Methodological quality was assessed...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Sung-A Kim Sook-Hyun Lee Jang-Hoon Kim Maurits van den Noort Peggy Bosch Tiana Won Sujung Yeo Sabina Lim Source Type: research

Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine
Am J Chin Med. 2021 May 27:1-19. doi: 10.1142/S0192415X21500531. Online ahead of print.ABSTRACTTraditional Chinese medicine (TCM) is a systematic medicine. It provides alternative strategies for the treatment of depression with its clinical experience, comprehensive diagnosis, and treatment theory. Chinese herbal medicine (CHM) is the major form of TCM prescription, and numerous CHMs have been demonstrated to possess remarkable antidepressant-like properties. A diversity of mechanisms have been implicated in CHM-associated antidepressant property. This paper reviewed the neuroplastic mechanisms underlying the antidepressan...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Baomei Xia Chang Chen Weiwei Tao Source Type: research

Effects of Stimulating Local and Distal Acupoints on Diabetic Gastroparesis: A New Insight in Revealing Acupuncture Therapeutics
In this study, diabetic gastroparesis rats were treated by needling Zhongwan (CV12) and Zusanli (ST36), and then used Single Photon Emission Computed Tomography-CT (SPECT-CT) technology to assess the effects of promoting gastric motility. In addition, morphological observation, immunohistochemical examination, and biomarker assays, such as determination of growth factor 1, motilin, and ghrelin contents in serum samples, were performed to better understand the impact of certain various acupuncture treatments. All of the therapies improved the symptoms of diabetic gastroparesis rats, according to the findings. Stimulating th...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bo Yu Mengmeng Sun Zhihong Wang Bing Zhu Jingquan Xue Wenjiang Yang Xinyan Gao Mujun Zhi Jiazhen Cao Jinying Zhao Xuewei Zhao Wu Liu Fuchun Wang Tie Li Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway
Am J Chin Med. 2021 May 27:1-19. doi: 10.1142/S0192415X21500580. Online ahead of print.ABSTRACTAlthough ginseng (Panax ginseng C.A. Meyer) has received extensive attention in the treatment and prevention of type 2 diabetes mellitus (T2DM) in the past few decades, there are few studies on the complications of T2DM. At present, obesity-linked diabetic nephropathy (DN) has become the most prevailing element of the end-stage renal failure in the world. The aim of this work is to evaluate the ameliorative effects of ginsenoside Rh1 (G-Rh1) on DN induced by high fat diet plus streptozotocin (HFD/STZ) through some potential and c...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Wen-Ya Su Ying Li Xuan Chen Xin Li Heng Wei Zhi Liu Qiong Shen Chen Chen Ying-Ping Wang Wei Li Source Type: research

Berberine and Ginsenoside Rb1 Ameliorate Depression-Like Behavior in Diabetic Rats
This study investigated the effects of the active ingredients of R. coptidis and ginseng, berberine and ginsenoside Rb1, on depression-like behavior in a rat diabetes model. The animal model was established via a high-fat diet and intraperitoneal injection of streptozotocin, while the animal's depression-like behavior was induced via chronic unpredictable mild stress. These experimental rats were divided into four groups: control, depression-like behavior (DLB), metformin plus fluoxetine hydrochloride (M+FH), and berberine plus ginsenoside Rb1 (B+GRb1) groups. Glucose metabolism and insulin resistance were evaluated by ora...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Jing-Hua Zhang Hui-Zeng Yang Hao Su Jun Song Yu Bai Lan Deng Chun-Peng Feng Hong-Xia Guo Yi Wang Xin Gao Yan Gu Zhong Zhen Yao Lu Source Type: research