Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation.
In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice. NASH was induced by feeding a methionine- and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Each diet group was also orally administered saline (group G0) or KRG extract (100, 200, or 400 mg/kg/day; groups G1, G2, and G4, respectively). KRG showed anti-inflammatory and antifibrogenic effects in the diet-induced NASH models. Furthermore, the expression levels of lipid metabolism-related genes were markedly decreased with KRG treatment in both diet-induced NASH group...
Source: The American Journal of Chinese Medicine - October 9, 2018 Category: Complementary Medicine Authors: Jeong H, Kim JW, Yang MS, Park C, Kim JH, Lim CW, Kim B Tags: Am J Chin Med Source Type: research

The Most Commonly Treated Acupuncture Indications in the United States: A Cross-Sectional Study.
In this study, we conducted a cross-sectional survey among 419 acupuncturists nation-wide to investigate the top 10 and top 99 acupuncture indications in private clinics in the United States. We found the top 10 indications to be: lower back pain, depression, anxiety, headache, arthritis, allergies, general pain, female infertility, insomnia, neck pain and frozen shoulder. Among the top 99 indications, pain represents the largest category; and mental health management, especially for mood disorders, is in greatest demand. The following popular groups are: immune system dysfunctions, gastrointestinal diseases, gynecology an...
Source: The American Journal of Chinese Medicine - October 9, 2018 Category: Complementary Medicine Authors: Wang H, Yang G, Wang S, Zheng X, Zhang W, Li Y Tags: Am J Chin Med Source Type: research

Acupuncture Application in Chronic Kidney Disease and its Potential Mechanisms.
In conclusion, acupuncture is proved to be beneficial for CKD patients. More research, however, is needed to verify the potential mechanisms. PMID: 30286626 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 6, 2018 Category: Complementary Medicine Authors: Xiong W, He FF, You RY, Xiong J, Wang YM, Zhang C, Meng XF, Su H Tags: Am J Chin Med Source Type: research

Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
This study was conducted to investigate the potential anticancer effects and the underlying mechanisms of QYJD and its active constituents, matrine and oxymatrine, in human colon cancer HT29 cells and in a dextran sulfate sodium (DSS)-induced colitis mouse model. QYJD and matrine effectively inhibited the proliferation and anchorage-independent growth of HT29 cells in a dose-dependent manner. QYJD and matrine also induced an Nrf2-mediated anti-oxidant response element-luciferase activity and upregulated the Nrf2-mediated anti-oxidative stress genes HO-1 and NQO1 at both the mRNA and protein levels. In the DSS-induced colit...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Fang R, Wu R, Zuo Q, Yin R, Zhang C, Wang C, Guo Y, Yang AY, Li W, Lin L, Kong AN Tags: Am J Chin Med Source Type: research

Therapeutic Potential of Naringin for Intervertebral Disc Degeneration: Involvement of Autophagy Against Oxidative Stress-Induced Apoptosis in Nucleus Pulposus Cells.
In conclusion, our study suggests that naringin can protect nucleus pulposus cells against apoptosis and ameliorate IDD in vivo, the mechanism may relate to its autophagy regulation. PMID: 30284462 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Zhang Z, Wang C, Lin J, Jin H, Wang K, Yan Y, Wang J, Wu C, Nisar M, Tian N, Wang X, Zhang X Tags: Am J Chin Med Source Type: research

Progress in Experimental and Clinical Research of the Diabetic Retinopathy Treatment Using Traditional Chinese Medicine.
Abstract Diabetic retinopathy (DR), one of the most common microvascular complications of diabetic mellitus, is currently the main cause of adult-acquired blindness. The pathogenesis of DR is complex and the current clinical application of various treatment methods cannot completely prevent the development of this disease. Many reports have been published regarding the treatment of DR with Traditional Chinese Medicine (TCM), which has received increasing attention from medical practitioners worldwide. Studies published between 1994 and April 2017 were collected from the CNKI, VIP, Medline and Web of Science databa...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Xu ZH, Gao YY, Zhang HT, Ruan KF, Feng Y Tags: Am J Chin Med Source Type: research

Chinese Herbal Medicine Glycyrrhiza inflataReduces A β Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
This study examined the neuroprotection effects of CHM extract Glycyrrhiza inflata (G. inflata) and its active constituents, licochalcone A and liquiritigenin in AD. We examined A[Formula: see text] aggregation inhibition, anti-oxidation and neuroprotection in Tet-On A[Formula: see text]-GFP 293/SH-SY5Y cells and anti-inflammatory potential in lipopolysaccharide (LPS)-stimulated RAW 264.7 and LPS and interferon (IFN)-[Formula: see text] (LPS/IFN-[Formula: see text])-activated BV-2 cells. In addition, we applied conditioned media (CM) of BV-2 cells primed with LPS/IFN-[Formula: see text] to A[Formula: see text]-GF...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Chiu YJ, Lee CM, Lin TH, Lin HY, Lee SY, Mesri M, Chang KH, Lin JY, Lee-Chen GJ, Chen CM Tags: Am J Chin Med Source Type: research

Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-[Formula: see text]B Signaling Pathway.
Abstract The cytokine C-X-C motif chemokine ligand 8 (CXCL8) is produced in the tumor microenvironment and has an important role in cancer pathogenesis. CXCL8 activates the nuclear factor (NF)-[Formula: see text]B signaling. However, the role of NF-[Formula: see text]B inactivation in apoptosis induced by negative regulation of CXCL8 remains unclear. Here, we assessed the effects of MRGX on the transcriptional activity of NF-[Formula: see text]B and the expression of tumor necrosis factor (TNF)-[Formula: see text]-stimulated target genes in liver cancer cells. Furthermore, we found that modified regular ginseng ex...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Cui ZY, Jo E, Jang HJ, Hwang IH, Lee KB, Yoo HS, Park SJ, Jung MK, Lee YW, Jang IS Tags: Am J Chin Med Source Type: research

Activity Dependent Mammalian Target of Rapamycin Pathway and Brain Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Effects of Puerarin.
Abstract Puerarin is a traditional Chinese medicine with beneficial effects of reduced depression-like behaviors in mice with stress. Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. Interestingly, BDNF and Akt downstream target, mammalian target of rapamycin (mTOR) mediate the fast-acting antidepressant properties of ketamine. Until now, the involvement of the mTOR signaling pathway or BDNF on puerarin-induced antidepressant effect remains unknown. We aimed to investigate whether the antidepressant-...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Huang CC, Tsai MH, Wu YC, Chen KT, Chuang HW, Chen Y, Tseng GW, Fu PI, Wei IH Tags: Am J Chin Med Source Type: research

Antidepressant Effects of Vaccinium bracteatum via Protection Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis.
Abstract The present study evaluates the anti-oxidative stress activity of Vaccinium bracteatum Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using in vitro models of hydrogen peroxide (H2O[Formula: see text]-induced neuronal damage. The results...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Oh DR, Kim Y, Choi EJ, Jo A, Shin J, Kang H, Lee SG, Kim J, Kim YR, Choi CY Tags: Am J Chin Med Source Type: research

Allyl Isothiocyanate Induces Autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells.
Abstract Allyl isothiocyanate (AITC), one of the most widely studied phytochemicals, inhibits the survival of human prostate cancer cells while minimally affecting normal prostate epithelial cells. Our study demonstrates the mechanism of AITC-induced cell death in prostate cancer cells. AITC induces autophagy in RV1 and PC3 cells, judging from the increased level of LC3-II protein in a dose- and time-dependent manner, but not in the normal prostate epithelial cell (PrEC). Inhibition of autophagy in AITC-treated cells decreased cell viability and enhanced apoptosis, suggesting that the autophagy played a protective...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Chen HE, Lin JF, Tsai TF, Lin YC, Chou KY, Hwang TI Tags: Am J Chin Med Source Type: research

Regulating Gut Flora Dysbiosis in Obese Mice by Electroacupuncture.
This study aimed to explore the impacts of electroacupuncture treatment on gut microbiota composition and function in obese mice. Pyrosequencing of 16S rRNA genes and Metagenomic analysis of the fecal microbiota were used for this purpose. The basic parameters of body weight, Lee's index, serum lipid and epididymal adipose weight were ameliorated significantly after introducing an electroacupuncture intervention. Acidobacteria, Cyanobacteria and Basidiomycota (Normal group) and Fusobacteria, Firmicutes and Spirochmycetes (Model group) were remarkably affluent at the phylum level. Bacteroides sp. CAG: 927 and Prevotella sp....
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Si YC, Miao WN, He JY, Chen L, Wang YL, Ding WJ Tags: Am J Chin Med Source Type: research

Marsdenia tenacissima: A Review of Traditional Uses, Phytochemistry and Pharmacology.
Abstract The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Nowadays, the extract of Marsdenia tenacissima, under the trademark of "Xiao-ai-ping", is widely used in clinic for the treatment of different cancers in China. To date, approximately 196 chemical ingredients covering steroids, triterpenes and organic acids have been identified from different parts of this plant. Steroids are the major char...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Wang P, Yang J, Zhu Z, Zhang X Tags: Am J Chin Med Source Type: research

Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease.
Abstract Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supp...
Source: The American Journal of Chinese Medicine - September 5, 2018 Category: Complementary Medicine Authors: Bae UJ, Park EO, Park J, Jung SJ, Ham H, Yu KW, Park YJ, Chae SW, Park BH Tags: Am J Chin Med Source Type: research

Panax notoginseng Inhibits Tumor Growth through Activating Macrophage to M1 Polarization.
Abstract Among the herbal ingredients of HangAmDan-B, a medicinal formula that redirects macrophages to become tumoricidal effectors, we found that Panax notoginseng (Burk.) F. H. Chen is the active component responsible for its macrophage-mediated antitumor activity. The water extracted roots of P. notoginseng (PN) did not affect the viability of RAW264.7 murine macrophage-like cells and murine Lewis lung carcinoma (LLC) cells up to a concentration of 100[Formula: see text][Formula: see text]g/mL. However, the transfer of culture media from PN-treated RAW264.7 cells suppressed the growth of LL...
Source: The American Journal of Chinese Medicine - August 31, 2018 Category: Complementary Medicine Authors: Kim B, Kim EY, Lee EJ, Han JH, Kwak CH, Jung YS, Lee SO, Chung TW, Ha KT Tags: Am J Chin Med Source Type: research

Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-[Formula: see text]B and Nrf2 Pathways.
Abstract Antrodia cinnamomea, a medicinal mushroom, has previously demonstrated anti-inflammatory activity, although the specific compound responsible for the effect remains unclear. The present study was designed to investigate the anti-inflammatory property of antrolone, a novel benzoid derived from A. cinnamomea mycelium, and to clarify the underlying mechanisms of action. To this end, murine macrophage RAW264.7 cells were treated with antrolone (0.1-30[Formula: see text][Formula: see text]M) 30[Formula: see text]min prior to stimulation with lipopolysaccharides (LPS, 0.1[Formula: see text][Formula: see text]g/...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Yen IC, Shi LS, Chung MC, Ahmetaj-Shala B, Chang TC, Lee SY Tags: Am J Chin Med Source Type: research

Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKK[Formula: see text]/[Formula: see text]-Mediated NF-[Formula: see text]B Pathway in Macrophages.
Abstract Lilium bulbs have long been used as Chinese traditional medicines to alleviate the symptoms of various human inflammatory diseases. However, mechanisms of Lilium bulb-mediated anti-inflammatory activity and the bioactive components in Lilium bulbs remain unknown. In the present study, the anti-inflammatory activity of Lilium bulbs and the underlying mechanism of action were investigated in macrophages using Lilium bulb ethanol extracts (Lb-EE). In a dose-dependent manner, Lb-EE inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and bone marrow-derived macrophages ...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Han SY, Yi YS, Jeong SG, Hong YH, Choi KJ, Hossain MA, Hwang H, Rho HS, Lee J, Kim JH, Cho JY Tags: Am J Chin Med Source Type: research

Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
In this study, the anti-inflammatory effect of neferine was investigated. Raw264.7 cells were stimulated with lipopolysaccharide (LPS) or LPS plus Z-VAD-fmk (Z-VAD). The inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (TNF-[Formula: see text]) and interleukin 6 (IL-6), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was determined. The protective effect of neferine was investigated in dextran sulfate sodium (DSS)-induced UC mouse model. Neferine significantly inhibited LPS and LPS plus Z-VAD induced secretion of nitrite, cytokines, and expressio...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wu X, Guo Y, Min X, Pei L, Chen X Tags: Am J Chin Med Source Type: research

Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer.
Abstract Bladder cancer has a high recurrence rate and requires adjuvant intravesical management after surgery. The use of traditional agents for bladder cancer therapy is constrained by their toxicity and limited efficacy. This emphasizes the need for the development of safer, more effective compounds such as instillation agents. Curcumin is the major component of turmeric, the powdered root of Curcuma longa, which is known for its anti-inflammatory, anti-oxidant and anticancer properties. First, a microarray profiling and qPCR analysis were conducted in the T24 and SV-HUC-1 cell lines. Then, we examined the pote...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wang K, Tan SL, Lu Q, Xu R, Cao J, Wu SQ, Wang YH, Zhao XK, Zhong ZH Tags: Am J Chin Med Source Type: research

Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition.
This study investigated whether a 30% ethanolic SP extract (SPEtOH) and its constituents can reduce CRAC currents ([Formula: see text]), and thus inhibit mast cell degranulation and T cell activation. In Jurkat T lymphocytes, we found that 3[Formula: see text]mg/mL SPEtOH inhibited the [Formula: see text] by [Formula: see text]%, whereas one of its constituents vitexin (100[Formula: see text][Formula: see text]M) inhibited the [Formula: see text] by [Formula: see text]%. Furthermore, in the RBL-2H3 mast cell, the [Formula: see text] was inhibited by 3[Formula: see text]mg/mL SPEtOH ([Formula: see text]%) and 100[Formula: s...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Kim HJ, Nam YR, Kim EJ, Nam JH, Kim WK Tags: Am J Chin Med Source Type: research

Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.
In conclusion, Rg3 deregulated tumor-related genes through alteration of the epigenetic methylation level leading to growth inhibition of cancer cells. PMID: 30149757 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Ham J, Lee S, Lee H, Jeong D, Park S, Kim SJ Tags: Am J Chin Med Source Type: research

Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats.
In conclusion, our results indicated that MLB exerted robust neuroprotective effects against SAH via suppressing neuroinflammation and apoptosis. These neuroprotective effects of MLB against SAH might be exerted via regulating the SIRT1/NF-[Formula: see text]B pathway. MLB or the SIRT1/NF-[Formula: see text]B pathway could be a novel and promising therapeutic strategy for SAH management. PMID: 30149758 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Peng Y, He P, Fan L, Xu H, Li J, Chen T, Ruan W, Dou Z, Chen G Tags: Am J Chin Med Source Type: research

Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion.
This study investigated the ameliorating effect of scutellarin (SCT) on spatial cognitive impairment and [Formula: see text]-amyloid (A[Formula: see text]) formation in rats with chronic cerebral hypoperfusion induced by permanent bilateral common carotid artery occlusion (pBCAO). SCT is a flavonoid in medicinal herb of Erigeron breviscapus (vant.) Hand. Mazz. known to have neuroprotective, antioxidative and anti-inflammatory effects. However, the beneficial effect and pivotal mechanism of SCT on cognitive impairment are still unclear. SCT was treated orally with two doses (10 or 30[Formula: see text]mg/kg) for 4 weeks. Re...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Shin JW, Kweon KJ, Kim DK, Kim P, Jeon TD, Maeng S, Sohn NW Tags: Am J Chin Med Source Type: research

Oleanolic Acid, A Novel Endothelin a Receptor Antagonist, Alleviated High Glucose-Induced Cardiomyocytes Injury.
Abstract Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure. Our previous study demonstrated that oleanolic acid (OA), a natural compound found in Chinese herbs had ET-1 antagonistic effects. We aimed to verify whether OA could ameliorate diabetes mellitus (DM)-induced injury in cardiomyocytes by reducing the antagonistic effects of the ET-1 pathway. For the induction of high glucose-related injury in cardiomyocytes, neonatal rat ventricular cardiomyocytes (...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wu D, Zhang Q, Yu Y, Zhang Y, Zhang M, Liu Q, Zhang E, Li S, Song G Tags: Am J Chin Med Source Type: research

Chinese Herbal Medicine for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Abstract Chinese herbal medicine (CHM) has been widely used in the treatment of advanced non-small-cell lung cancer (NSCLC), but their efficacy and safety remain controversial. We sought to comprehensively aggregate and evaluate the available evidence on the efficacy and safety of the combination treatment with CHM and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in NSCLC patients. Our exhausted and systematical searching strategy yielded 64 related randomized controlled trials involving 4384 patients. Compared with EGFR-TKIs therapy alone, meta-analysis showed significant differences fa...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Zhang XW, Liu W, Jiang HL, Mao B Tags: Am J Chin Med Source Type: research

Administrations of Preoperative Shenmai Injection and Postoperative Shenfu Injection, Two Ginseng Containing TCM Formulas, Improve Cognitive Dysfunction in Aged Rats.
Abstract Postoperative cognitive dysfunction (POCD) is one of the major complications in patients who have undergone surgeries. Reduction of surgery-induced inflammation and perioperative stress responses may prevent the development of POCD. As recent experimental data have suggested, Shenmai and Shenfu injections, two ginseng containing formulations, may improve cognition. We designed this study using aged rats as an experimental model to determine the effect of combined perioperative Shenmai injection and Shenfu injection in preventing the development of POCD and exploring the underlying mechanism of this interv...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Zhang WL, Chi YL, Wang LZ, Liu H, Zhao LX, Su F Tags: Am J Chin Med Source Type: research

Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation.
Abstract Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory and debilitating disease that involves the systemic imbalance of the immune network. Previous studies have shown that acupuncture can help treat RA. However, its specific mechanisms are not fully understood. Thus, the present study was designed to clarify the mechanisms of acupuncture acted on RA via immune network modulation using complete Freund's adjuvant (CFA)-induced arthritic rats. Results revealed that manual acupuncture (MA) could alleviate the inflammation and pain of infected joints. Moreover, MA could effectively stimulate...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Xu Y, Hong S, Zhao X, Wang S, Xu Z, Ding S, Zhang K, Zhang Y, Xu L, Yu N, Zhao T, Yan Y, Yang F, Liu Y, Yu K, Liu B, Guo Y, Pang G Tags: Am J Chin Med Source Type: research

Application of Traditional Chinese Medicines as Personalized Therapy in Human Cancers.
Abstract Although lots of great achievements have been gained in the battle against cancer during the past decades, cancer is still the leading cause of death in the world including in developing countries such as China. Traditional Chinese medicine (TCM) is popular in Chinese and East Asian societies as well as some other Western countries and plays an active role in the modern healthcare system including patients with cancer, which may act as a potential effective strategy in treating human cancers. In this review, we aimed to introduce the mechanisms of TCM compound, as an option of individualized therapy, in t...
Source: The American Journal of Chinese Medicine - July 9, 2018 Category: Complementary Medicine Authors: Wang S, Long S, Wu W Tags: Am J Chin Med Source Type: research

Dendropanax morbifera Prevents Cardiomyocyte Hypertrophy by Inhibiting the Sp1/GATA4 Pathway.
Abstract An extract of Dendropanax morbifera branch exerts antioxidant, anti-inflammatory, antithrombotic, and anticancer activities. The purpose of this study was to investigate the effect of the extract in isoproterenol-induced cardiac hypertrophy. Phalloidin staining showed that treatment with the extract dramatically prevents isoproterenol-induced H9c2 cell enlargement and the expression of cardiac hypertrophic marker genes, including atrial natriuretic peptide (ANP) and B-type brain natriuretic peptide (BNP). Further, pretreatment with the extract decreased isoproterenol-induced GATA4 and Sp1 expression in H9...
Source: The American Journal of Chinese Medicine - July 9, 2018 Category: Complementary Medicine Authors: Sun S, Li T, Jin L, Piao ZH, Liu B, Ryu Y, Choi SY, Kim GR, Jeong JE, Wi AJ, Lee SJ, Kee HJ, Jeong MH Tags: Am J Chin Med Source Type: research

Effects of Celastrus Orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions.
Abstract The extract of Celastrus orbiculatus (COE) have been shown to possess anti-Helicobacter pylori (H. pylori) activity and anticancer effects in vitro and in vivo. However, the molecular mechanism by which COE on precancerous lesions of gastric cancer (PLGC) has not been fully elucidated so far. The purpose of this study is to evaluate the effect and mechanism of COE in the rat model of PLGC, after the rat model of PLGC was successfully constructed. The effects of COE in gastric mucosa of rats with PLGC were tested using routine pathology and a transmission electron microscope (TEM) analysis. The protein and...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Zhu YD, Hu L, Li P, Zhang M, Liu YQ Tags: Am J Chin Med Source Type: research

Curcuminoids Induce Reactive Oxygen Species and Autophagy to Enhance Apoptosis in Human Oral Cancer Cells.
Abstract Numerous studies support the use of herbal medicine or natural products for chemotherapy in human cancers. Reports have associated curcumin (CUR), dimethoxy curcumin (DMC) and bisdemethoxycurcumin (BDMC) with numerous biological activities including anticancer activities, but no available information have shown that these induced apoptotic cell death and autophagy in human oral cancer cells. In the present study, we investigated the effect of CUR, DMC and BDMC on the cell viability, apoptotic cell death, reactive oxygen species (ROS), Ca[Formula: see text], mitochondria membrane potential (MMP) and caspas...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Hsiao YT, Kuo CL, Chueh FS, Liu KC, Bau DT, Chung JG Tags: Am J Chin Med Source Type: research

Therapeutic Effect of Glycyrrhizin Arginine Salt on Rat Cholestatic Cirrhosis and its Mechanism.
Abstract To investigate the therapeutic effect of glycyrrhizin arginine salt on rat cholestatic cirrhosis, we subjected male Sprague Dawley rats to common bile duct ligation for 14 days and treated them with distilled water (model group), arginine, or a low or high dose of glycyrrhizin arginine salt by gavage. A sham-operated group was used as a control group. Treatment with glycyrrhizin arginine salt substantially improved animal growth rates, reduced the ratio of liver weight to body weight and decreased total bilirubin, aspartate aminotransferase, 8-isoprostane and malondialdehyde compared with the values measu...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Zhang H, Lin Y, Zhen Y, Hu G, Meng X, Li X, Men X Tags: Am J Chin Med Source Type: research

Panax notoginseng for Inflammation-Related Chronic Diseases: A Review on the Modulations of Multiple Pathways.
In conclusion, this review identified inflammatory pathway as the key signaling for determining the efficacy of P. notoginseng on chronic diseases. It is speculated that P. notoginseng is a multi-targeted agent with an anti-inflammatory property in the adjuvant and alternative treatment of human chronic diseases. PMID: 29976083 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Xu Y, Tan HY, Li S, Wang N, Feng Y Tags: Am J Chin Med Source Type: research

Flos Magnoliae Inhibits Chloride Secretion via ANO1 Inhibition in Calu-3 Cells.
Abstract Flos Magnoliae (FM, Chinese name: Xin-yi) is an oriental medicinal herb commonly used for symptomatic relief from allergic rhinitis, sinusitis, and headache, including in traditional Chinese and Korean medicine formulations. FM inhibits histamine release from mast cells and cytokine secretion from T cells. However, the mechanism of action of FM on the anoctamin-1 (ANO1) ion channel, which is responsible for nasal hypersecretion in allergic rhinitis, has not been elucidated. Therefore, in this study, we investigated the effect of a 30% ethanolic extract of FM (FMEtOH) and its chemical constituents on ANO1 ...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Kim HJ, Nam YR, Nam JH Tags: Am J Chin Med Source Type: research

Kaempferol's Protective Effect on Ethanol-Induced Mouse Primary Hepatocytes Injury Involved in the Synchronous Inhibition of SP1, Hsp70 and CYP2E1.
This study investigated the protective mechanism(s) of kaempferol on ethanol-induced toxicity by dynamic alteration of SP1, Hsp70 and CYP2E1 among the nucleus and different organelles in hepatocytes. After ethanol treatment alone and co-incubation hepatocytes with kaempferol, protein levels of CYP2E1, Hsp70, and SP1 were determined in vitro (western blotting and immunofluorescence). Hepatocytes' viability was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) methods. Glutathione (GSH) levels were evaluated for ethanol-induced oxidative stress. In the ethanol-treated hepatocytes, kaem...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Zhou B, Jiang Z, Li X, Zhang X Tags: Am J Chin Med Source Type: research

Galectin-12 is Involved in Corn Silk-Induced Anti-Adipogenesis and Anti-Obesity Effects.
Abstract Obesity is a significant risk factor for various diseases. It is a clinical condition caused by the excessive accumulation of fat, which has a negative impact on human health. Galactin-12 is an adipocyte-expressed protein and possesses adipocyte-inducing activity. We investigated the expression level of candidate proteins involved in galactin-12-mediated adipocyte differentiation pathway. We performed a high-throughput screening assay to monitor galectin-12 promoter activity using 105 traditional Chinese herbs. Corn silk extract and [Formula: see text]-sitosterol reduced the expression of galactin-12 prom...
Source: The American Journal of Chinese Medicine - July 5, 2018 Category: Complementary Medicine Authors: Hsu YA, Kuo YH, Chen CS, Chen YC, Huang CC, Chang CY, Lin CJ, Lin CW, Lin HJ, Liu FT, Wan L Tags: Am J Chin Med Source Type: research

Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling.
Abstract The hierarchical tumor propagation or cancer stem cells (CSCs) model of carcinogenesis postulates that like physiologic adult stem cell (ASC), the CSCs positioned at the apex of any tumor population form the crux of tumor evolution with a constitutive regenerative capacity and differentiation potential. The propagation and recurrence of the characteristically heterogeneous and therapy-resistant hepatocellular carcinoma (HCC), adds to accumulating evidence to support this CSCs model. Based on the multi-etiologic basis of HCC formation which among others, focuses on the disruption of the canonical Wnt signa...
Source: The American Journal of Chinese Medicine - May 24, 2018 Category: Complementary Medicine Authors: Liu M, Bamodu OA, Kuo KT, Lee WH, Lin YK, Wu ATH, M H, Tzeng YM, Yeh CT, Tsai JT Tags: Am J Chin Med Source Type: research

Hesperidin Suppresses Renin-Angiotensin System Mediated NOX2 Over-Expression and Sympathoexcitation in 2K-1C Hypertensive Rats.
Abstract Hesperidin, a flavonoid derived from citrus fruits, possesses several beneficial effects including anti-oxidation and anti-inflammation. The aim of this study was to investigate the effects of hesperidin on the renin-angiotensin system (RAS) cascade that mediated oxidative stress and sympathoexcitation in two-kidney, one-clipped (2K-1C) hypertensive rats. 2K-1C hypertension was induced in male Sprague-Dawley rats. Hypertensive rats were treated with hesperidin at 20[Formula: see text]mg/kg or 40[Formula: see text]mg/kg or losartan at 10[Formula: see text]mg/kg beginning at three weeks after surgery and th...
Source: The American Journal of Chinese Medicine - May 13, 2018 Category: Complementary Medicine Authors: Wunpathe C, Potue P, Maneesai P, Bunbupha S, Prachaney P, Kukongviriyapan U, Kukongviriyapan V, Pakdeechote P Tags: Am J Chin Med Source Type: research

Hominis placenta Suppresses Acute Lung Inflammation by Activating Nrf2.
Abstract Hominis placenta (HP), a dried human placenta, has been known to target liver, lung, or kidney meridians, improving the functions associated with these meridians in traditional Chinese or Asian medicine (TCM). Since recent studies implicate an HP extract in suppressing inflammation, we investigated whether an aqueous HP extract can ameliorate inflammation that occurred in the lungs. When administered with a single intratracheal lipopolysaccharide (LPS), C57BL/6 mice developed an acute neutrophilic lung inflammation along with an increased expression of pro-inflammatory cytokine genes. However, this was di...
Source: The American Journal of Chinese Medicine - May 13, 2018 Category: Complementary Medicine Authors: Kim TH, Choi JY, Kim KH, Kwun MJ, Han CW, Won R, Lee JJ, Kim JI, Joo M Tags: Am J Chin Med Source Type: research

1,[Formula: see text]2,[Formula: see text]3,[Formula: see text]4,[Formula: see text]6-Penta-O-Galloyl- β-D-Glucose from Galla rhois Ameliorates Renal Tubular Injury and Microvascular Inflammation in Acute Kidney Injury Rats.
We examined protective effects of PGG on IRI-induced acute AKI. Clamping both renal arteries for 45[Formula: see text]min induced isechemia and then reperfusion. Treatment with PGG (10[Formula: see text]mg/kg/day and 50[Formula: see text]mg/kg/day for four days) significantly ameliorated urine volume, urine osmolality, creatinine clearance (Ccr) and blood urea nitrogen (BUN). In addition, PGG increased aquaporine 1/2/3, Na[Formula: see text]-K[Formula: see text]-ATPase and urea transporter (UT-B) and decreased ICAM-1, MCP-1, and HMGB-1 expression. In this histopathologic study, PGG improved glomerular and tubular damage. I...
Source: The American Journal of Chinese Medicine - May 13, 2018 Category: Complementary Medicine Authors: Park JH, Kho MC, Oh HC, Kim YC, Yoon JJ, Lee YJ, Kang DG, Lee HS Tags: Am J Chin Med Source Type: research

Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice.
Abstract Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion o...
Source: The American Journal of Chinese Medicine - May 13, 2018 Category: Complementary Medicine Authors: Fu H, Jin L, Shao X, Li Y, Chen F, Shou Z, Tang X, Ji B, Shou Q Tags: Am J Chin Med Source Type: research

Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts.
We examined the restoring properties of quercetin on human dermal fibroblasts (HDFs). Quercetin directly reduced either intracellular or extracellular ROS levels in aged HDFs. To find the aging-related target genes by quercetin, microarray analysis was performed and two up-regulated genes LPL and KCNE2 were identified. Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs. Silencing of LPL and KCNE2 decreased the expression levels of antioxidant enzymes such as superoxide dismutase and cata...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Sohn EJ, Kim JM, Kang SH, Kwon J, An HJ, Sung JS, Cho KA, Jang IS, Choi JS Tags: Am J Chin Med Source Type: research

The Immunoregulatory Effects of Traditional Chinese Medicine on Psoriasis via its Action on Interleukin: Advances and Considerations.
Abstract Psoriasis is a chronic inflammatory cutaneous disease characterized by clinical manifestations of erythema and white scales. The pathogenesis of psoriasis is not yet clear. Despite a combination of hormonal therapy and physiotherapy used in Western medicine, the condition often relapses after withdrawal of drugs. Traditional Chinese medicine (TCM) has therapeutic features and may be a clinically effective formula by regulating unbalanced immune systems, such as by targeting interleukins. In this paper, we review recent research about how Chinese medicine immunoregulates psoriasis via interleukins, and sys...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Wu M, Deng Y, Li S, Chen Y, Guo D, Jin X, Xu Q, Li B, Li F Tags: Am J Chin Med Source Type: research

Inhibitory Effects of Amentoflavone and Orobol on Daclatasvir-Induced Resistance-Associated Variants of Hepatitis C Virus.
In this study, we screened a library of natural compounds to identify natural HCV inhibitors. The library of the pure compounds extracted from Chinese herbs deposited in the chemical bank of National Research Institute of Chinese Medicine (NRICM), Taiwan was screened in the cell culture-derived HCV (HCVcc) system. We identified the flavone or flavan-based compounds amentoflavone, 7,4[Formula: see text]-dihydroxyflavanone, and orobol with the inhibition of viral entry, replication, and translation of the HCV life cycle. Amentoflavone and orobol also showed inhibitory effects on resistant-associated variants to the NS5A inhi...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Lee WP, Lan KL, Liao SX, Huang YH, Hou MC, Lan KH Tags: Am J Chin Med Source Type: research

Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy.
Abstract Traditional Chinese medicine (TCM) has a long history and been widely used in prevention and treatment of epilepsy in China. This paper is intended to review the advances in the active anticonvulsant compounds isolated from herbs in the prescription of TCM in the treatment of epilepsy. These compounds were introduced with the details including classification, CAS number specific structure and druggability data. Meanwhile, much of the research in these compounds in the last two decades has shown that they exhibited favorable pharmacological properties in treatment of epilepsy both in in vivo and in vitro m...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Zhao Z, He X, Ma C, Wu S, Cuan Y, Sun Y, Bai Y, Huang L, Chen X, Gao T, Zheng X Tags: Am J Chin Med Source Type: research

Hepatoprotective Effect of Wedelolactone against Concanavalin A-Induced Liver Injury in Mice.
In conclusion, these findings demonstrate the inhibitory potential of wedelolactone in immune-mediated liver injury in vivo, and show that this protection is associated with modulation of the NF-[Formula: see text]B signaling pathway. PMID: 29737211 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Luo Q, Ding J, Zhu L, Chen F, Xu L Tags: Am J Chin Med Source Type: research

Baicalein Ameliorates Pulmonary Arterial Hypertension Caused by Monocrotaline through Downregulation of ET-1 and ETAR in Pneumonectomized Rats.
Abstract Baicalein (BE) extracted from Scutellaria baicalensis Georgi is able to alleviate various cardiovascular and inflammatory diseases. However, the effects of BE on pulmonary arterial hypertension (PAH) remain unknown. Therefore, the present study aimed to examine whether BE ameliorates pneumonectomy and monocrotaline-induced PAH in rats and further investigate the underlying molecular mechanisms. Administration of BE greatly attenuated the development of PAH as evidenced by an improvement of its characteristic features, including elevation of right ventricular systolic pressure, right ventricular hypertroph...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Hsu WL, Lin YC, Jeng JR, Chang HY, Chou TC Tags: Am J Chin Med Source Type: research

Pachymic Acid Sensitizes Gastric Cancer Cells to Radiation Therapy by Upregulating Bax through Hypoxia.
Abstract We have previously shown that pachymic acid (PA) inhibited tumorigenesis of gastric cancer (GC) cells. However, the exact mechanism underlying the radiation response of GC was still elusive. To evaluate the effects of PA treatment on radiation response of GC cell lines both in vitro and in vivo, a colony formation assay and xenograft mouse model were employed. Changes in Bax and HIF1[Formula: see text] expressions were assessed in GC cells following PA treatment. Luciferase reporter and chromatin immune-precipitation assays were carried out to investigate the regulation of Bax through HIF1[Formula: see te...
Source: The American Journal of Chinese Medicine - May 8, 2018 Category: Complementary Medicine Authors: Lu C, Cai D, Ma J Tags: Am J Chin Med Source Type: research

Protective Effects of Ginsenoside Rb1 against Blood-Brain Barrier Damage Induced by Human Immunodeficiency Virus-1 Tat Protein and Methamphetamine in Sprague-Dawley Rats.
In this study, we aimed to examine the effects of methamphetamine and HIV-1 Tat protein on the blood-brain barrier function and to determine whether ginsenoside Rb1 (GsRb1) plays a role in protecting the BBB. Sprague-Dawley rats were divided into four groups. The experimental groups received methamphetamine and HIV-1 Tat protein or both and the control group received saline or GsRb1 pretreatment. Oxidative stress-related factors, tight junction (TJ) proteins, blood-brain barrier permeability, and morphological changes were recorded in each group. The results showed that the group treated with Methamphetamine[Formula: see t...
Source: The American Journal of Chinese Medicine - April 27, 2018 Category: Complementary Medicine Authors: Li J, Zeng B, Hu X, Li Z, Zhang D, Yang G, Dai J, Zeng X Tags: Am J Chin Med Source Type: research

The Polyphenolic Compound Curcumin Conjugation with an Alkyne Moiety in the Process of Autophagy.
Abstract Curcumin is a hydrophobic polyphenol derived from turmeric: the rhizome of the herb Curcumalonga. Autophagy is an evolutionarily conserved process, in which cellular proteins and organelles are engulfed in autophagosome and then fuses with lysosome for degradation. Our previous study showed that Curcumin activates lysosome and induce autophagy through inhibition of AKT (protein kinase K, PKB)-mammalian target of rapamycin (mTOR) pathway. But whether Curucmin affects the fusion of autophagosome-lysosome is still not clear. Here, we used Curcumin-probe conjugation with an alkyne moiety to label mouse embryo...
Source: The American Journal of Chinese Medicine - April 4, 2018 Category: Complementary Medicine Authors: Yan P, Sun X, Chen X, Chen Y, Wang X, Su D, Zhou H, Gao L, Lu L, Wang J, Zhang J Tags: Am J Chin Med Source Type: research