Efficacy of Traditional Chinese Medicine Combined with Selective Serotonin Reuptake Inhibitors on the Treatment for Parkinson's Disease with Depression: A Systematic Review and Meta-Analysis
Am J Chin Med. 2021 Mar 3:1-17. doi: 10.1142/S0192415X21500282. Online ahead of print.ABSTRACTDepression is a common neuropsychiatric symptom of Parkinson's disease (PD), resulting in a lower quality of life and cognitive impairment in PD patients. Traditional Chinese medicine (TCM) formulas have been widely used in neurodegenerative disease and neuropsychic disorders to improve life quality of patients in ethnomedicine. TCM formulas combined with selective serotonin reuptake inhibitors (SSRIs) also have a positive effect on depressed PD compared with SSRIs as reported by several clinical studies. However, the results are ...
Source: The American Journal of Chinese Medicine - March 4, 2021 Category: Complementary Medicine Authors: Si-Tong Feng Xiao-Le Wang Ya-Ting Wang Yu-He Yuan Zhi-Peng Li Nai-Hong Chen Zhen-Zhen Wang Yi Zhang Source Type: research

Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway
In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway.PMID:33657989 | DOI:10.1142/S0192415X21500361 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - March 4, 2021 Category: Complementary Medicine Authors: Hyo In Kim Sol Ji Lee Yu-Jeong Choi Min Jeong Kim Tai Young Kim Seong-Gyu Ko Source Type: research

Protective Effect of Dihydrokaempferol on Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
In this study, we investigated the protective effect by DHK against APAP-induced liver injury in vitro and in vivo and the potential mechanism of action. Cell viability assays were used to determine the effects of DHK against APAP-induced liver injury. The levels of reactive oxygen species (ROS), serum alanine/aspartate aminotransferases (ALT/AST), liver myeloperoxidase (MPO), and malondialdehyde (MDA) were measured and analyzed to evaluate the effects of DHK on APAP-induced liver injury. Western blotting, immunofluorescence staining, RT-PCR, and Transmission Electron Microscope were carried out to detect the signaling pat...
Source: The American Journal of Chinese Medicine - March 4, 2021 Category: Complementary Medicine Authors: Jiaqi Zhang Cheng Hu Xiulong Li Li Liang Mingcai Zhang Bo Chen Xinhua Liu Dicheng Yang Source Type: research

Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin
In this study, PCR array screened a significant increase of miR-200c in BT-549 and MDA-MB-231 cells after ISL treatment, and ISH exerted that miR-200c was expressed at a low level in breast cancer tissue of patients. We also found that ISL could up-regulate miR-200c, resulting in the inhibition of epithelial-mesenchymal transition. Meanwhile, ISL could inhibit metastasis and tumor growth in nude mice models through the increase of miR-200c. Further study displayed that ISL decreased c-Jun expression through the increase of miR-200c. Interestingly, we also detected that ISL might increase miR-200c expression through the dem...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Fu Peng Hailin Tang Junrong Du Jianping Chen Cheng Peng Source Type: research

Role of Purinergic Signaling in Acupuncture Therapeutics
Am J Chin Med. 2021 Feb 25:1-15. doi: 10.1142/S0192415X21500294. Online ahead of print.ABSTRACTAcupuncture is a therapeutic treatment that is well recognized in many countries. However, the initiation mechanisms of acupuncture are not well understood. Purinergic signaling has been considered a key signaling pathway in acupuncture in recent years. Acupuncture-induced ATP is mainly produced by mast cells and fibroblasts, and ATP is gradually hydrolyzed into adenosine. ATP and adenosine further participate in the process of acupuncture information transmission to the nervous and immune systems through specific purine receptor...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Zhi-Ying Lv Yong-Qing Yang Lei-Miao Yin Source Type: research

Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors
In this study, we retrospectively analyzed MDS patients that received ADP treatment in the past 9 years and confirmed that ADP improves patients' anemia and prolongs overall survival in intermediate-risk MDS patients. Then, we used the MDS transgenic mice model and cell line to explore the drug mechanism. In normal and MDS cells, ADP does not show cellular toxicity but promotes differentiation. In mouse MDS models, we observed that ADP showed significant efficacy on promoting erythropoiesis. In the BFU-E and CFU-E assays, ADP could promote erythropoiesis not only in normal clones but also in MDS clones. Mechanistically, we...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Teng Fan Xiaomin Feng Asumi Yokota Weiyi Liu Yuting Tang Xiaomei Yan Haiyan Xiao Yue Wang Zhongyang Deng Pan Zhao Mingjing Wang Hongzhi Wang Rou Ma Xiaomei Hu Gang Huang Source Type: research

Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling
Am J Chin Med. 2021 Feb 25:1-17. doi: 10.1142/S0192415X21500245. Online ahead of print.ABSTRACTGastric cancer is a common malignancy worldwide and is associated with high morbidity and mortality rates. However, very little is known about the underlying mechanism in human gastric cancer cells. Baicalein (BAI), a widely used Chinese herbal medicine, has shown anticancer effects on many types of human cancer cell lines. Here, we investigated the molecular mechanisms underlying BAI action on gastric cancer cell proliferation and migration. The results showed that BAI can expressively inhibit cell proliferation, colony-forming ...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Dan Qiao Jingchun Jin Jian Xing Yingying Zhang Nailing Jia Xiangshan Ren Zhenhua Lin Ningyi Jin Liyan Chen Yingshi Piao Source Type: research

20( < em > S < /em > )-Ginsenoside Rg3 Inhibits Lung Cancer Cell Proliferation by Targeting EGFR-Mediated Ras/Raf/MEK/ERK Pathway
Am J Chin Med. 2021 Feb 25:1-13. doi: 10.1142/S0192415X2150035X. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer death in the world and classified into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). As tyrosine kinase inhibitors (TKIs), several triterpenoid saponins can target to epidermal growth factor receptor (EGFR), a widely used molecular therapeutic target, to exhibit remarkable anti-proliferative activities in cancer cells. As one of triterpenoid saponins, 20([Formula: see text])-ginsenoside Rg3 [20([Formula: see text])-Rg3] was confirmed to be an EGFR-TKI in this work...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Yuan Liang Tiehua Zhang Siyuan Jing Peng Zuo Tiezhu Li Yongjun Wang Shaochen Xing Jie Zhang Zhengyi Wei Source Type: research

Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin
In this study, PCR array screened a significant increase of miR-200c in BT-549 and MDA-MB-231 cells after ISL treatment, and ISH exerted that miR-200c was expressed at a low level in breast cancer tissue of patients. We also found that ISL could up-regulate miR-200c, resulting in the inhibition of epithelial-mesenchymal transition. Meanwhile, ISL could inhibit metastasis and tumor growth in nude mice models through the increase of miR-200c. Further study displayed that ISL decreased c-Jun expression through the increase of miR-200c. Interestingly, we also detected that ISL might increase miR-200c expression through the dem...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Fu Peng Hailin Tang Junrong Du Jianping Chen Cheng Peng Source Type: research

Role of Purinergic Signaling in Acupuncture Therapeutics
Am J Chin Med. 2021 Feb 25:1-15. doi: 10.1142/S0192415X21500294. Online ahead of print.ABSTRACTAcupuncture is a therapeutic treatment that is well recognized in many countries. However, the initiation mechanisms of acupuncture are not well understood. Purinergic signaling has been considered a key signaling pathway in acupuncture in recent years. Acupuncture-induced ATP is mainly produced by mast cells and fibroblasts, and ATP is gradually hydrolyzed into adenosine. ATP and adenosine further participate in the process of acupuncture information transmission to the nervous and immune systems through specific purine receptor...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Zhi-Ying Lv Yong-Qing Yang Lei-Miao Yin Source Type: research

Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors
In this study, we retrospectively analyzed MDS patients that received ADP treatment in the past 9 years and confirmed that ADP improves patients' anemia and prolongs overall survival in intermediate-risk MDS patients. Then, we used the MDS transgenic mice model and cell line to explore the drug mechanism. In normal and MDS cells, ADP does not show cellular toxicity but promotes differentiation. In mouse MDS models, we observed that ADP showed significant efficacy on promoting erythropoiesis. In the BFU-E and CFU-E assays, ADP could promote erythropoiesis not only in normal clones but also in MDS clones. Mechanistically, we...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Teng Fan Xiaomin Feng Asumi Yokota Weiyi Liu Yuting Tang Xiaomei Yan Haiyan Xiao Yue Wang Zhongyang Deng Pan Zhao Mingjing Wang Hongzhi Wang Rou Ma Xiaomei Hu Gang Huang Source Type: research

Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling
Am J Chin Med. 2021 Feb 25:1-17. doi: 10.1142/S0192415X21500245. Online ahead of print.ABSTRACTGastric cancer is a common malignancy worldwide and is associated with high morbidity and mortality rates. However, very little is known about the underlying mechanism in human gastric cancer cells. Baicalein (BAI), a widely used Chinese herbal medicine, has shown anticancer effects on many types of human cancer cell lines. Here, we investigated the molecular mechanisms underlying BAI action on gastric cancer cell proliferation and migration. The results showed that BAI can expressively inhibit cell proliferation, colony-forming ...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Dan Qiao Jingchun Jin Jian Xing Yingying Zhang Nailing Jia Xiangshan Ren Zhenhua Lin Ningyi Jin Liyan Chen Yingshi Piao Source Type: research

20( < em > S < /em > )-Ginsenoside Rg3 Inhibits Lung Cancer Cell Proliferation by Targeting EGFR-Mediated Ras/Raf/MEK/ERK Pathway
Am J Chin Med. 2021 Feb 25:1-13. doi: 10.1142/S0192415X2150035X. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer death in the world and classified into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). As tyrosine kinase inhibitors (TKIs), several triterpenoid saponins can target to epidermal growth factor receptor (EGFR), a widely used molecular therapeutic target, to exhibit remarkable anti-proliferative activities in cancer cells. As one of triterpenoid saponins, 20([Formula: see text])-ginsenoside Rg3 [20([Formula: see text])-Rg3] was confirmed to be an EGFR-TKI in this work...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Yuan Liang Tiehua Zhang Siyuan Jing Peng Zuo Tiezhu Li Yongjun Wang Shaochen Xing Jie Zhang Zhengyi Wei Source Type: research

Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin
In this study, PCR array screened a significant increase of miR-200c in BT-549 and MDA-MB-231 cells after ISL treatment, and ISH exerted that miR-200c was expressed at a low level in breast cancer tissue of patients. We also found that ISL could up-regulate miR-200c, resulting in the inhibition of epithelial-mesenchymal transition. Meanwhile, ISL could inhibit metastasis and tumor growth in nude mice models through the increase of miR-200c. Further study displayed that ISL decreased c-Jun expression through the increase of miR-200c. Interestingly, we also detected that ISL might increase miR-200c expression through the dem...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Fu Peng Hailin Tang Junrong Du Jianping Chen Cheng Peng Source Type: research

Role of Purinergic Signaling in Acupuncture Therapeutics
Am J Chin Med. 2021 Feb 25:1-15. doi: 10.1142/S0192415X21500294. Online ahead of print.ABSTRACTAcupuncture is a therapeutic treatment that is well recognized in many countries. However, the initiation mechanisms of acupuncture are not well understood. Purinergic signaling has been considered a key signaling pathway in acupuncture in recent years. Acupuncture-induced ATP is mainly produced by mast cells and fibroblasts, and ATP is gradually hydrolyzed into adenosine. ATP and adenosine further participate in the process of acupuncture information transmission to the nervous and immune systems through specific purine receptor...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Zhi-Ying Lv Yong-Qing Yang Lei-Miao Yin Source Type: research

Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors
In this study, we retrospectively analyzed MDS patients that received ADP treatment in the past 9 years and confirmed that ADP improves patients' anemia and prolongs overall survival in intermediate-risk MDS patients. Then, we used the MDS transgenic mice model and cell line to explore the drug mechanism. In normal and MDS cells, ADP does not show cellular toxicity but promotes differentiation. In mouse MDS models, we observed that ADP showed significant efficacy on promoting erythropoiesis. In the BFU-E and CFU-E assays, ADP could promote erythropoiesis not only in normal clones but also in MDS clones. Mechanistically, we...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Teng Fan Xiaomin Feng Asumi Yokota Weiyi Liu Yuting Tang Xiaomei Yan Haiyan Xiao Yue Wang Zhongyang Deng Pan Zhao Mingjing Wang Hongzhi Wang Rou Ma Xiaomei Hu Gang Huang Source Type: research

Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling
Am J Chin Med. 2021 Feb 25:1-17. doi: 10.1142/S0192415X21500245. Online ahead of print.ABSTRACTGastric cancer is a common malignancy worldwide and is associated with high morbidity and mortality rates. However, very little is known about the underlying mechanism in human gastric cancer cells. Baicalein (BAI), a widely used Chinese herbal medicine, has shown anticancer effects on many types of human cancer cell lines. Here, we investigated the molecular mechanisms underlying BAI action on gastric cancer cell proliferation and migration. The results showed that BAI can expressively inhibit cell proliferation, colony-forming ...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Dan Qiao Jingchun Jin Jian Xing Yingying Zhang Nailing Jia Xiangshan Ren Zhenhua Lin Ningyi Jin Liyan Chen Yingshi Piao Source Type: research

20( < em > S < /em > )-Ginsenoside Rg3 Inhibits Lung Cancer Cell Proliferation by Targeting EGFR-Mediated Ras/Raf/MEK/ERK Pathway
Am J Chin Med. 2021 Feb 25:1-13. doi: 10.1142/S0192415X2150035X. Online ahead of print.ABSTRACTLung cancer is the leading cause of cancer death in the world and classified into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). As tyrosine kinase inhibitors (TKIs), several triterpenoid saponins can target to epidermal growth factor receptor (EGFR), a widely used molecular therapeutic target, to exhibit remarkable anti-proliferative activities in cancer cells. As one of triterpenoid saponins, 20([Formula: see text])-ginsenoside Rg3 [20([Formula: see text])-Rg3] was confirmed to be an EGFR-TKI in this work...
Source: The American Journal of Chinese Medicine - March 1, 2021 Category: Complementary Medicine Authors: Yuan Liang Tiehua Zhang Siyuan Jing Peng Zuo Tiezhu Li Yongjun Wang Shaochen Xing Jie Zhang Zhengyi Wei Source Type: research

The Role of Acupuncture on the Gut-Brain-Microbiota Axis in Irritable Bowel Syndrome
Am J Chin Med. 2021 Feb 20:1-30. doi: 10.1142/S0192415X21500154. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous ...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Kiangyada Yaklai Sintip Pattanakuhar Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research

Trends and Patterns in Traditional Chinese Medicine Use Among Chinese Population in Late Adulthood: An Eight-Year Repeated Panel Survey
This study aimed to document the longitudinal trends and the patterns by demographical characteristics in the prevalence of TCM among the middle-aged and elderly Chinese population. This study used nationally representative longitudinal survey data from the China Health and Retirement Longitudinal Study (CHARLS), covering approximately 20,000 individuals in each panel survey from 2011 to 2018. The questions regarding medication use in the questionnaire was used to identify the TCM users. The prevalence of using TCM for treating chronic diseases among the patients with chronic diseases stabilized between 2011 and 2018, whil...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Lu Xu Jing Hu Lili Liu Siyan Zhan Shengfeng Wang Source Type: research

A Review of Pharmacological and Toxicological Effects of < em > Sophora tonkinensis < /em > with Bioinformatics Prediction
Am J Chin Med. 2021 Feb 20:1-31. doi: 10.1142/S0192415X21500178. Online ahead of print.ABSTRACTSophora tonkinensis Gagnep. (ST) (Fabaceae) is distributed chiefly in south-central and southeast China and Vietnam. In traditional Chinese medicine theory, the root and rhizome of ST are toxic and mainly used in the treatment of pharyngeal and laryngeal diseases. Modern studies provide new insights into the pharmacological and toxicological aspects of ST. The pharmacological and toxicological properties of ST were reviewed in this paper based on the literature from Google Scholar and CNKI, and the bioinformatics platforms were a...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Shuai-Nan Zhang Xu-Zhao Li Long-Yan Tan Kui-Yuan Zhu Source Type: research

Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of < em > Citrus < /em > Peel (Chenpi) for Treating Complicated Diseases
Am J Chin Med. 2021 Feb 20:1-21. doi: 10.1142/S0192415X2150018X. Online ahead of print.ABSTRACTCitri Reticulatae Pericarpium (CRP), also known as Chenpi in Chinese, is the dry mature peel of Citrus reticulata Blanco or its cultivated varieties. CRP as the health-care food and dietary supplement has been widely used in various diseases. However, the potential pharmacological mechanisms of CRP to predict and treat various diseases have not yet been fully elucidated. A systems pharmacology-based approach is developed by integrating absorption, distribution, metabolism, and excretion screening, multiple target fishing, network...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Wei Zhou Ziyi Chen Aiping Lu Zhigang Liu Source Type: research

Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research

Medicinal < em > Inula < /em > Species: Phytochemistry, Biosynthesis, and Bioactivities
Am J Chin Med. 2021 Feb 20:1-44. doi: 10.1142/S0192415X21500166. Online ahead of print.ABSTRACTAs a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary me...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Cheng-Peng Sun Zi-Li Jia Xiao-Kui Huo Xiang-Ge Tian Lei Feng Chao Wang Bao-Jing Zhang Wen-Yu Zhao Xiao-Chi Ma Source Type: research

Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine
Am J Chin Med. 2021 Feb 20:1-32. doi: 10.1142/S0192415X21500130. Online ahead of print.ABSTRACTIntestinal flora is essential for maintaining host health and plays a unique role in transforming Traditional Chinese Medicine (TCM). TCM, as a bodyguard, has saved countless lives and maintained human health in the long history, especially in this COVID-19 pandemic. Pains of diseases have been removed from the effective TCM therapy, such as TCM preparation, moxibustion, and acupuncture. With the development of life science and technology, the wisdom and foresight of TCM has been more displayed. Furthermore, TCM has been also inh...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Xiao Li Dan Wu Jingjie Niu Yanping Sun Qiuhong Wang Bingyou Yang Haixue Kuang Source Type: research

Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway
This study aims to explore the protective effect and mechanism of ligustrazine on PAH. In the in vivo experiment, monocrotaline (MCT) was used to induce PAH in rats, and then ligustrazine (40, 80, 160 mg/kg/day) or sildenafil (25 mg/kg/day) was administered. Four weeks later, hemodynamic changes, right ventricular hypertrophy index, lung morphological characteristics, inflammatory factors, phosphoinositide 3-kinase (PI3K), and AKT expression were evaluated. In addition, primary rat PASMCs were extracted by the tissue adhesion method, a proliferation model was established with platelet-derived growth factor-BB (PDGF-BB), an...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Huiping Huang Lingjin Kong Shaohua Luan Chuanzong Qi Fanrong Wu Source Type: research

Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases
Am J Chin Med. 2021 Feb 20:1-23. doi: 10.1142/S0192415X21500191. Online ahead of print.ABSTRACTThe intestinal tract plays an essential role in protecting tissues from the invasion of external harmful substances due to impaired barrier function. Furthermore, it participates in immunomodulation by intestinal microorganisms, which is important in health. When the intestinal tract is destroyed, it can lose its protective function, resulting in multiple systemic complications. In severe cases, it may lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Thus far, there are no cur...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yajing Shi Yufang Leng Disheng Liu Xin Liu Yixing Ren Jianmin Zhang Feng Chen Source Type: research

The Role of Acupuncture on the Gut-Brain-Microbiota Axis in Irritable Bowel Syndrome
Am J Chin Med. 2021 Feb 20:1-30. doi: 10.1142/S0192415X21500154. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous ...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Kiangyada Yaklai Sintip Pattanakuhar Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research

Trends and Patterns in Traditional Chinese Medicine Use Among Chinese Population in Late Adulthood: An Eight-Year Repeated Panel Survey
This study aimed to document the longitudinal trends and the patterns by demographical characteristics in the prevalence of TCM among the middle-aged and elderly Chinese population. This study used nationally representative longitudinal survey data from the China Health and Retirement Longitudinal Study (CHARLS), covering approximately 20,000 individuals in each panel survey from 2011 to 2018. The questions regarding medication use in the questionnaire was used to identify the TCM users. The prevalence of using TCM for treating chronic diseases among the patients with chronic diseases stabilized between 2011 and 2018, whil...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Lu Xu Jing Hu Lili Liu Siyan Zhan Shengfeng Wang Source Type: research

A Review of Pharmacological and Toxicological Effects of < em > Sophora tonkinensis < /em > with Bioinformatics Prediction
Am J Chin Med. 2021 Feb 20:1-31. doi: 10.1142/S0192415X21500178. Online ahead of print.ABSTRACTSophora tonkinensis Gagnep. (ST) (Fabaceae) is distributed chiefly in south-central and southeast China and Vietnam. In traditional Chinese medicine theory, the root and rhizome of ST are toxic and mainly used in the treatment of pharyngeal and laryngeal diseases. Modern studies provide new insights into the pharmacological and toxicological aspects of ST. The pharmacological and toxicological properties of ST were reviewed in this paper based on the literature from Google Scholar and CNKI, and the bioinformatics platforms were a...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Shuai-Nan Zhang Xu-Zhao Li Long-Yan Tan Kui-Yuan Zhu Source Type: research

Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of < em > Citrus < /em > Peel (Chenpi) for Treating Complicated Diseases
Am J Chin Med. 2021 Feb 20:1-21. doi: 10.1142/S0192415X2150018X. Online ahead of print.ABSTRACTCitri Reticulatae Pericarpium (CRP), also known as Chenpi in Chinese, is the dry mature peel of Citrus reticulata Blanco or its cultivated varieties. CRP as the health-care food and dietary supplement has been widely used in various diseases. However, the potential pharmacological mechanisms of CRP to predict and treat various diseases have not yet been fully elucidated. A systems pharmacology-based approach is developed by integrating absorption, distribution, metabolism, and excretion screening, multiple target fishing, network...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Wei Zhou Ziyi Chen Aiping Lu Zhigang Liu Source Type: research

Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research

Medicinal < em > Inula < /em > Species: Phytochemistry, Biosynthesis, and Bioactivities
Am J Chin Med. 2021 Feb 20:1-44. doi: 10.1142/S0192415X21500166. Online ahead of print.ABSTRACTAs a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary me...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Cheng-Peng Sun Zi-Li Jia Xiao-Kui Huo Xiang-Ge Tian Lei Feng Chao Wang Bao-Jing Zhang Wen-Yu Zhao Xiao-Chi Ma Source Type: research

Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine
Am J Chin Med. 2021 Feb 20:1-32. doi: 10.1142/S0192415X21500130. Online ahead of print.ABSTRACTIntestinal flora is essential for maintaining host health and plays a unique role in transforming Traditional Chinese Medicine (TCM). TCM, as a bodyguard, has saved countless lives and maintained human health in the long history, especially in this COVID-19 pandemic. Pains of diseases have been removed from the effective TCM therapy, such as TCM preparation, moxibustion, and acupuncture. With the development of life science and technology, the wisdom and foresight of TCM has been more displayed. Furthermore, TCM has been also inh...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Xiao Li Dan Wu Jingjie Niu Yanping Sun Qiuhong Wang Bingyou Yang Haixue Kuang Source Type: research

Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway
This study aims to explore the protective effect and mechanism of ligustrazine on PAH. In the in vivo experiment, monocrotaline (MCT) was used to induce PAH in rats, and then ligustrazine (40, 80, 160 mg/kg/day) or sildenafil (25 mg/kg/day) was administered. Four weeks later, hemodynamic changes, right ventricular hypertrophy index, lung morphological characteristics, inflammatory factors, phosphoinositide 3-kinase (PI3K), and AKT expression were evaluated. In addition, primary rat PASMCs were extracted by the tissue adhesion method, a proliferation model was established with platelet-derived growth factor-BB (PDGF-BB), an...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Huiping Huang Lingjin Kong Shaohua Luan Chuanzong Qi Fanrong Wu Source Type: research

Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases
Am J Chin Med. 2021 Feb 20:1-23. doi: 10.1142/S0192415X21500191. Online ahead of print.ABSTRACTThe intestinal tract plays an essential role in protecting tissues from the invasion of external harmful substances due to impaired barrier function. Furthermore, it participates in immunomodulation by intestinal microorganisms, which is important in health. When the intestinal tract is destroyed, it can lose its protective function, resulting in multiple systemic complications. In severe cases, it may lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Thus far, there are no cur...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yajing Shi Yufang Leng Disheng Liu Xin Liu Yixing Ren Jianmin Zhang Feng Chen Source Type: research

The Role of Acupuncture on the Gut-Brain-Microbiota Axis in Irritable Bowel Syndrome
Am J Chin Med. 2021 Feb 20:1-30. doi: 10.1142/S0192415X21500154. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous ...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Kiangyada Yaklai Sintip Pattanakuhar Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research

Trends and Patterns in Traditional Chinese Medicine Use Among Chinese Population in Late Adulthood: An Eight-Year Repeated Panel Survey
This study aimed to document the longitudinal trends and the patterns by demographical characteristics in the prevalence of TCM among the middle-aged and elderly Chinese population. This study used nationally representative longitudinal survey data from the China Health and Retirement Longitudinal Study (CHARLS), covering approximately 20,000 individuals in each panel survey from 2011 to 2018. The questions regarding medication use in the questionnaire was used to identify the TCM users. The prevalence of using TCM for treating chronic diseases among the patients with chronic diseases stabilized between 2011 and 2018, whil...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Lu Xu Jing Hu Lili Liu Siyan Zhan Shengfeng Wang Source Type: research

A Review of Pharmacological and Toxicological Effects of < em > Sophora tonkinensis < /em > with Bioinformatics Prediction
Am J Chin Med. 2021 Feb 20:1-31. doi: 10.1142/S0192415X21500178. Online ahead of print.ABSTRACTSophora tonkinensis Gagnep. (ST) (Fabaceae) is distributed chiefly in south-central and southeast China and Vietnam. In traditional Chinese medicine theory, the root and rhizome of ST are toxic and mainly used in the treatment of pharyngeal and laryngeal diseases. Modern studies provide new insights into the pharmacological and toxicological aspects of ST. The pharmacological and toxicological properties of ST were reviewed in this paper based on the literature from Google Scholar and CNKI, and the bioinformatics platforms were a...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Shuai-Nan Zhang Xu-Zhao Li Long-Yan Tan Kui-Yuan Zhu Source Type: research

Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of < em > Citrus < /em > Peel (Chenpi) for Treating Complicated Diseases
Am J Chin Med. 2021 Feb 20:1-21. doi: 10.1142/S0192415X2150018X. Online ahead of print.ABSTRACTCitri Reticulatae Pericarpium (CRP), also known as Chenpi in Chinese, is the dry mature peel of Citrus reticulata Blanco or its cultivated varieties. CRP as the health-care food and dietary supplement has been widely used in various diseases. However, the potential pharmacological mechanisms of CRP to predict and treat various diseases have not yet been fully elucidated. A systems pharmacology-based approach is developed by integrating absorption, distribution, metabolism, and excretion screening, multiple target fishing, network...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Wei Zhou Ziyi Chen Aiping Lu Zhigang Liu Source Type: research

Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research

Medicinal < em > Inula < /em > Species: Phytochemistry, Biosynthesis, and Bioactivities
Am J Chin Med. 2021 Feb 20:1-44. doi: 10.1142/S0192415X21500166. Online ahead of print.ABSTRACTAs a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary me...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Cheng-Peng Sun Zi-Li Jia Xiao-Kui Huo Xiang-Ge Tian Lei Feng Chao Wang Bao-Jing Zhang Wen-Yu Zhao Xiao-Chi Ma Source Type: research

Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine
Am J Chin Med. 2021 Feb 20:1-32. doi: 10.1142/S0192415X21500130. Online ahead of print.ABSTRACTIntestinal flora is essential for maintaining host health and plays a unique role in transforming Traditional Chinese Medicine (TCM). TCM, as a bodyguard, has saved countless lives and maintained human health in the long history, especially in this COVID-19 pandemic. Pains of diseases have been removed from the effective TCM therapy, such as TCM preparation, moxibustion, and acupuncture. With the development of life science and technology, the wisdom and foresight of TCM has been more displayed. Furthermore, TCM has been also inh...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Xiao Li Dan Wu Jingjie Niu Yanping Sun Qiuhong Wang Bingyou Yang Haixue Kuang Source Type: research

Ligustrazine Suppresses Platelet-Derived Growth Factor-BB-Induced Pulmonary Artery Smooth Muscle Cell Proliferation and Inflammation by Regulating the PI3K/AKT Signaling Pathway
This study aims to explore the protective effect and mechanism of ligustrazine on PAH. In the in vivo experiment, monocrotaline (MCT) was used to induce PAH in rats, and then ligustrazine (40, 80, 160 mg/kg/day) or sildenafil (25 mg/kg/day) was administered. Four weeks later, hemodynamic changes, right ventricular hypertrophy index, lung morphological characteristics, inflammatory factors, phosphoinositide 3-kinase (PI3K), and AKT expression were evaluated. In addition, primary rat PASMCs were extracted by the tissue adhesion method, a proliferation model was established with platelet-derived growth factor-BB (PDGF-BB), an...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Huiping Huang Lingjin Kong Shaohua Luan Chuanzong Qi Fanrong Wu Source Type: research

Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases
Am J Chin Med. 2021 Feb 20:1-23. doi: 10.1142/S0192415X21500191. Online ahead of print.ABSTRACTThe intestinal tract plays an essential role in protecting tissues from the invasion of external harmful substances due to impaired barrier function. Furthermore, it participates in immunomodulation by intestinal microorganisms, which is important in health. When the intestinal tract is destroyed, it can lose its protective function, resulting in multiple systemic complications. In severe cases, it may lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Thus far, there are no cur...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yajing Shi Yufang Leng Disheng Liu Xin Liu Yixing Ren Jianmin Zhang Feng Chen Source Type: research

The Role of Acupuncture on the Gut-Brain-Microbiota Axis in Irritable Bowel Syndrome
Am J Chin Med. 2021 Feb 20:1-30. doi: 10.1142/S0192415X21500154. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic dysfunction of the gastrointestinal tract, commonly characterized by abdominal pain or abdominal discomfort. These symptoms can substantially reduce the quality of life and work productivity of the patients. The exact pathogenesis of IBS remains unclear, as it has become apparent that multiple pathways are activated in the condition, including inflammation, immunology, neurology and psychology. Recent evidence has shown that symptoms in IBS are related to the dysfunction of the nervous ...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Kiangyada Yaklai Sintip Pattanakuhar Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research

Trends and Patterns in Traditional Chinese Medicine Use Among Chinese Population in Late Adulthood: An Eight-Year Repeated Panel Survey
This study aimed to document the longitudinal trends and the patterns by demographical characteristics in the prevalence of TCM among the middle-aged and elderly Chinese population. This study used nationally representative longitudinal survey data from the China Health and Retirement Longitudinal Study (CHARLS), covering approximately 20,000 individuals in each panel survey from 2011 to 2018. The questions regarding medication use in the questionnaire was used to identify the TCM users. The prevalence of using TCM for treating chronic diseases among the patients with chronic diseases stabilized between 2011 and 2018, whil...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Lu Xu Jing Hu Lili Liu Siyan Zhan Shengfeng Wang Source Type: research

A Review of Pharmacological and Toxicological Effects of < em > Sophora tonkinensis < /em > with Bioinformatics Prediction
Am J Chin Med. 2021 Feb 20:1-31. doi: 10.1142/S0192415X21500178. Online ahead of print.ABSTRACTSophora tonkinensis Gagnep. (ST) (Fabaceae) is distributed chiefly in south-central and southeast China and Vietnam. In traditional Chinese medicine theory, the root and rhizome of ST are toxic and mainly used in the treatment of pharyngeal and laryngeal diseases. Modern studies provide new insights into the pharmacological and toxicological aspects of ST. The pharmacological and toxicological properties of ST were reviewed in this paper based on the literature from Google Scholar and CNKI, and the bioinformatics platforms were a...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Shuai-Nan Zhang Xu-Zhao Li Long-Yan Tan Kui-Yuan Zhu Source Type: research

Systems Pharmacology-Based Strategy to Explore the Pharmacological Mechanisms of < em > Citrus < /em > Peel (Chenpi) for Treating Complicated Diseases
Am J Chin Med. 2021 Feb 20:1-21. doi: 10.1142/S0192415X2150018X. Online ahead of print.ABSTRACTCitri Reticulatae Pericarpium (CRP), also known as Chenpi in Chinese, is the dry mature peel of Citrus reticulata Blanco or its cultivated varieties. CRP as the health-care food and dietary supplement has been widely used in various diseases. However, the potential pharmacological mechanisms of CRP to predict and treat various diseases have not yet been fully elucidated. A systems pharmacology-based approach is developed by integrating absorption, distribution, metabolism, and excretion screening, multiple target fishing, network...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Wei Zhou Ziyi Chen Aiping Lu Zhigang Liu Source Type: research

Mistletoe Extract Targets the STAT3-FOXM1 Pathway to Induce Apoptosis and Inhibits Metastasis in Breast Cancer Cells
Am J Chin Med. 2021 Feb 20:1-18. doi: 10.1142/S0192415X21500221. Online ahead of print.ABSTRACTMistletoe extracts (Viscum album L.) have been widely used as complementary and alternative medicines for the treatment of cancer, and their cytotoxic effects have been reported on various types of cancer. However, the molecular targets of mistletoe extracts have not been well studied. Herein, we investigated molecules associated with the in vitro and in vivo anticancer effects of mistletoe extract using 4T1 murine breast cancer cells. Mistletoe extract induced apoptosis and inhibited the signal transducer and activator of transc...
Source: The American Journal of Chinese Medicine - February 24, 2021 Category: Complementary Medicine Authors: Yun-Suk Kwon So-Young Chun Min-Kyoung Kim Hong-Yan Nan ChuHee Lee Soyoung Kim Source Type: research