Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

Schisandrin B Attenuates Colitis-Associated Colorectal Cancer through SIRT1 Linked SMURF2 Signaling
In conclusion, the present study revealed that schisandrin B suppressed SIRT1 protein expression, and SIRT1 is negatively correlated with the induction of SMURF2, which inhibited cell growth and metastasis of colon cancer. Schisandrin B could be a leading compound, which will contribute to finding novel potential agents and therapeutic targets for colon cancer.PMID:34632965 | DOI:10.1142/S0192415X21500841 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 11, 2021 Category: Complementary Medicine Authors: Zhichen Pu Weiwei Zhang Minhui Wang Maodi Xu Haitang Xie Jun Zhao Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

< em > Schisandra sphenanthera < /em > : A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications
Am J Chin Med. 2021 Sep 23:1-46. doi: 10.1142/S0192415X21500749. Online ahead of print.ABSTRACTSchisandra sphenanthera Rehd. et Wils (S. sphenanthera) is a single species of Schisandra genus, Magnoliaceae family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. S. sphenanthera is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from S. sphenanthera, including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly ...
Source: The American Journal of Chinese Medicine - September 24, 2021 Category: Complementary Medicine Authors: Shiqi Huang Dongdong Zhang Yuze Li Hao Fan Yuanyuan Liu Wenli Huang Chong Deng Wei Wang Xiaomei Song Source Type: research

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties
Am J Chin Med. 2021 Sep 16:1-21. doi: 10.1142/S0192415X21500750. Online ahead of print.ABSTRACTBiochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the po...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Jia Yan Panda Qiu Xinyu Zhang Yuanyuan Zhang Linjing Mi Cheng Peng Xiaoqi Pan Fu Peng Source Type: research

Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials
This study is to evaluate clinical effectiveness of Chinese herbal medicine (CHM) on breast cancer by conducting meta-analyses on 81 randomized controlled trials (RCTs) with a total of 7215 subjects from eight databases. All RCTs compared patients using Western therapy alone and those using additional CHM therapy to evaluate the difference of primary (tumor response, mean time to progression (mTTP), overall survival (OS) and progression free survival (PFS)) and secondary outcome measures (tumor markers). Results showed that under the RECIST1.1 criteria, 52% patients with additional CHM therapy (67%, under WHO criteria) ach...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Venice Wing-Tung Ho Hor-Yue Tan Wei Guo Sha Li Ning Wang Wei Meng Tsz-Him So Edwin Chau-Leung Yu Yibin Feng Source Type: research

ERRATUM: Effect of Scutellarin on Neurogenesis in Neonatal Hypoxia-Ischemia Rat Model: Potential Mechanisms of Action
Am J Chin Med. 2021 Sep 16:1-2. doi: 10.1142/S0192415X21920014. Online ahead of print.NO ABSTRACTPMID:34530699 | DOI:10.1142/S0192415X21920014 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Liu-Lin Xiong Ya-Xin Tan Ruo-Lan Du Yuan Peng Lu-Lu Xue Jia Liu Mohammed Al-Hawwas Larisa Bobrovskaya Dong-Hui Liu Li Chen Ting-Hua Wang Xin-Fu Zhou Source Type: research

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties
Am J Chin Med. 2021 Sep 16:1-21. doi: 10.1142/S0192415X21500750. Online ahead of print.ABSTRACTBiochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the po...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Jia Yan Panda Qiu Xinyu Zhang Yuanyuan Zhang Linjing Mi Cheng Peng Xiaoqi Pan Fu Peng Source Type: research

Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials
This study is to evaluate clinical effectiveness of Chinese herbal medicine (CHM) on breast cancer by conducting meta-analyses on 81 randomized controlled trials (RCTs) with a total of 7215 subjects from eight databases. All RCTs compared patients using Western therapy alone and those using additional CHM therapy to evaluate the difference of primary (tumor response, mean time to progression (mTTP), overall survival (OS) and progression free survival (PFS)) and secondary outcome measures (tumor markers). Results showed that under the RECIST1.1 criteria, 52% patients with additional CHM therapy (67%, under WHO criteria) ach...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Venice Wing-Tung Ho Hor-Yue Tan Wei Guo Sha Li Ning Wang Wei Meng Tsz-Him So Edwin Chau-Leung Yu Yibin Feng Source Type: research

ERRATUM: Effect of Scutellarin on Neurogenesis in Neonatal Hypoxia-Ischemia Rat Model: Potential Mechanisms of Action
Am J Chin Med. 2021 Sep 16:1-2. doi: 10.1142/S0192415X21920014. Online ahead of print.NO ABSTRACTPMID:34530699 | DOI:10.1142/S0192415X21920014 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Liu-Lin Xiong Ya-Xin Tan Ruo-Lan Du Yuan Peng Lu-Lu Xue Jia Liu Mohammed Al-Hawwas Larisa Bobrovskaya Dong-Hui Liu Li Chen Ting-Hua Wang Xin-Fu Zhou Source Type: research

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties
Am J Chin Med. 2021 Sep 16:1-21. doi: 10.1142/S0192415X21500750. Online ahead of print.ABSTRACTBiochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the po...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Jia Yan Panda Qiu Xinyu Zhang Yuanyuan Zhang Linjing Mi Cheng Peng Xiaoqi Pan Fu Peng Source Type: research

Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials
This study is to evaluate clinical effectiveness of Chinese herbal medicine (CHM) on breast cancer by conducting meta-analyses on 81 randomized controlled trials (RCTs) with a total of 7215 subjects from eight databases. All RCTs compared patients using Western therapy alone and those using additional CHM therapy to evaluate the difference of primary (tumor response, mean time to progression (mTTP), overall survival (OS) and progression free survival (PFS)) and secondary outcome measures (tumor markers). Results showed that under the RECIST1.1 criteria, 52% patients with additional CHM therapy (67%, under WHO criteria) ach...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Venice Wing-Tung Ho Hor-Yue Tan Wei Guo Sha Li Ning Wang Wei Meng Tsz-Him So Edwin Chau-Leung Yu Yibin Feng Source Type: research

ERRATUM: Effect of Scutellarin on Neurogenesis in Neonatal Hypoxia-Ischemia Rat Model: Potential Mechanisms of Action
Am J Chin Med. 2021 Sep 16:1-2. doi: 10.1142/S0192415X21920014. Online ahead of print.NO ABSTRACTPMID:34530699 | DOI:10.1142/S0192415X21920014 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Liu-Lin Xiong Ya-Xin Tan Ruo-Lan Du Yuan Peng Lu-Lu Xue Jia Liu Mohammed Al-Hawwas Larisa Bobrovskaya Dong-Hui Liu Li Chen Ting-Hua Wang Xin-Fu Zhou Source Type: research

Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties
Am J Chin Med. 2021 Sep 16:1-21. doi: 10.1142/S0192415X21500750. Online ahead of print.ABSTRACTBiochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of Trifolium pratense L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. The publications collected from PubMed, ScienceDirect, and Wiley databases were summarized for the last 10 years. Then, the po...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Jia Yan Panda Qiu Xinyu Zhang Yuanyuan Zhang Linjing Mi Cheng Peng Xiaoqi Pan Fu Peng Source Type: research

Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials
This study is to evaluate clinical effectiveness of Chinese herbal medicine (CHM) on breast cancer by conducting meta-analyses on 81 randomized controlled trials (RCTs) with a total of 7215 subjects from eight databases. All RCTs compared patients using Western therapy alone and those using additional CHM therapy to evaluate the difference of primary (tumor response, mean time to progression (mTTP), overall survival (OS) and progression free survival (PFS)) and secondary outcome measures (tumor markers). Results showed that under the RECIST1.1 criteria, 52% patients with additional CHM therapy (67%, under WHO criteria) ach...
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Venice Wing-Tung Ho Hor-Yue Tan Wei Guo Sha Li Ning Wang Wei Meng Tsz-Him So Edwin Chau-Leung Yu Yibin Feng Source Type: research

ERRATUM: Effect of Scutellarin on Neurogenesis in Neonatal Hypoxia-Ischemia Rat Model: Potential Mechanisms of Action
Am J Chin Med. 2021 Sep 16:1-2. doi: 10.1142/S0192415X21920014. Online ahead of print.NO ABSTRACTPMID:34530699 | DOI:10.1142/S0192415X21920014 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - September 17, 2021 Category: Complementary Medicine Authors: Liu-Lin Xiong Ya-Xin Tan Ruo-Lan Du Yuan Peng Lu-Lu Xue Jia Liu Mohammed Al-Hawwas Larisa Bobrovskaya Dong-Hui Liu Li Chen Ting-Hua Wang Xin-Fu Zhou Source Type: research

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
Am J Chin Med. 2021 Sep 11:1-16. doi: 10.1142/S0192415X2150083X. Online ahead of print.ABSTRACTToosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Treatment of OC cells with TSN resulted in colony formation reduction,...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Ge Wang Xiu-Qi Fan Lu Li Yan Li Bian Shi Ke-Xin Xing Qi-Long Gao Source Type: research

< em > Helianthus Annuus < /em > L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress
In this study, the AS model induced by high-fat diet (HFD) mice that lacked apolipoprotein E (Apoe[Formula: see text] received feed containing 5% HAL for 24 weeks. After administration, the analysis of plaque on aorta was conducted, and the possible mechanisms were further explored. With HAL treatment, the size of atherosclerotic lesions in HFD-induced AS model mice was reduced. HAL ameliorated dyslipidemia and decreased the combined ratio. HAL up-regulated concentrations of superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) and down-regulated concentrations of malondialdehyde (MDA) in the ao...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Jianbing Wang Shijun Shan Anqi Lyu Yinsheng Wan Jun Zhang Source Type: research

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
Am J Chin Med. 2021 Sep 11:1-16. doi: 10.1142/S0192415X2150083X. Online ahead of print.ABSTRACTToosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Treatment of OC cells with TSN resulted in colony formation reduction,...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Ge Wang Xiu-Qi Fan Lu Li Yan Li Bian Shi Ke-Xin Xing Qi-Long Gao Source Type: research

< em > Helianthus Annuus < /em > L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress
In this study, the AS model induced by high-fat diet (HFD) mice that lacked apolipoprotein E (Apoe[Formula: see text] received feed containing 5% HAL for 24 weeks. After administration, the analysis of plaque on aorta was conducted, and the possible mechanisms were further explored. With HAL treatment, the size of atherosclerotic lesions in HFD-induced AS model mice was reduced. HAL ameliorated dyslipidemia and decreased the combined ratio. HAL up-regulated concentrations of superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) and down-regulated concentrations of malondialdehyde (MDA) in the ao...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Jianbing Wang Shijun Shan Anqi Lyu Yinsheng Wan Jun Zhang Source Type: research

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
Am J Chin Med. 2021 Sep 11:1-16. doi: 10.1142/S0192415X2150083X. Online ahead of print.ABSTRACTToosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Treatment of OC cells with TSN resulted in colony formation reduction,...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Ge Wang Xiu-Qi Fan Lu Li Yan Li Bian Shi Ke-Xin Xing Qi-Long Gao Source Type: research

< em > Helianthus Annuus < /em > L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress
In this study, the AS model induced by high-fat diet (HFD) mice that lacked apolipoprotein E (Apoe[Formula: see text] received feed containing 5% HAL for 24 weeks. After administration, the analysis of plaque on aorta was conducted, and the possible mechanisms were further explored. With HAL treatment, the size of atherosclerotic lesions in HFD-induced AS model mice was reduced. HAL ameliorated dyslipidemia and decreased the combined ratio. HAL up-regulated concentrations of superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) and down-regulated concentrations of malondialdehyde (MDA) in the ao...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Jianbing Wang Shijun Shan Anqi Lyu Yinsheng Wan Jun Zhang Source Type: research

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
Am J Chin Med. 2021 Sep 11:1-16. doi: 10.1142/S0192415X2150083X. Online ahead of print.ABSTRACTToosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Treatment of OC cells with TSN resulted in colony formation reduction,...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Ge Wang Xiu-Qi Fan Lu Li Yan Li Bian Shi Ke-Xin Xing Qi-Long Gao Source Type: research

< em > Helianthus Annuus < /em > L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress
In this study, the AS model induced by high-fat diet (HFD) mice that lacked apolipoprotein E (Apoe[Formula: see text] received feed containing 5% HAL for 24 weeks. After administration, the analysis of plaque on aorta was conducted, and the possible mechanisms were further explored. With HAL treatment, the size of atherosclerotic lesions in HFD-induced AS model mice was reduced. HAL ameliorated dyslipidemia and decreased the combined ratio. HAL up-regulated concentrations of superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) and down-regulated concentrations of malondialdehyde (MDA) in the ao...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Jianbing Wang Shijun Shan Anqi Lyu Yinsheng Wan Jun Zhang Source Type: research

Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
Am J Chin Med. 2021 Sep 11:1-16. doi: 10.1142/S0192415X2150083X. Online ahead of print.ABSTRACTToosendanin (TSN) is a triterpenoid extracted from the bark or fruits of Melia toosendan Sieb et Zucc, which is a traditional Chinese medicine and mainly grows in China and India. TSN has been verified to possess antitumor activities on various human cancers, whereas the effects of TSN on ovarian cancer (OC) has not been reported yet. Here, TSN was shown to significantly inhibit proliferation of SKOV3 and OVCAR3 cell lines in a dose- and time-dependent manner. Treatment of OC cells with TSN resulted in colony formation reduction,...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Ge Wang Xiu-Qi Fan Lu Li Yan Li Bian Shi Ke-Xin Xing Qi-Long Gao Source Type: research

< em > Helianthus Annuus < /em > L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress
In this study, the AS model induced by high-fat diet (HFD) mice that lacked apolipoprotein E (Apoe[Formula: see text] received feed containing 5% HAL for 24 weeks. After administration, the analysis of plaque on aorta was conducted, and the possible mechanisms were further explored. With HAL treatment, the size of atherosclerotic lesions in HFD-induced AS model mice was reduced. HAL ameliorated dyslipidemia and decreased the combined ratio. HAL up-regulated concentrations of superoxide dismutase (SOD), nitric oxide (NO) and glutathione peroxidase (GSH-Px) and down-regulated concentrations of malondialdehyde (MDA) in the ao...
Source: The American Journal of Chinese Medicine - September 15, 2021 Category: Complementary Medicine Authors: Jianbing Wang Shijun Shan Anqi Lyu Yinsheng Wan Jun Zhang Source Type: research

Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway
In this study, we showed that pretreatment with cordycepin significantly attenuated palmitic acid (PA)-induced cytotoxicity, reactive oxygen species (ROS) generation, and inflammatory responses. We found that PA decreased phosphorylation of Akt, eNOS, and bioavailability of nitric oxide (NO), which in turn activated NF-[Formula: see text]B and the downstream inflammatory responses. All these detrimental events were markedly blocked by pretreatment with cordycepin. Moreover, cordycepin ameliorated destabilization of mitochondrial permeability, cytosolic calcium rises, and apoptotic features caused by PA. In addition, all th...
Source: The American Journal of Chinese Medicine - September 7, 2021 Category: Complementary Medicine Authors: Chang-Wen Ku Tsung-Jung Ho Chih-Yang Huang Pei-Ming Chu Hsiu-Chung Ou Pei-Ling Hsieh Source Type: research

Puerarin Inhibits the PERK-eIF2[Formula: see text]-ATF4-CHOP Pathway through Inactivating JAK2/STAT3 Signal in Pancreatic beta-Cells
Am J Chin Med. 2021 Sep 6:1-16. doi: 10.1142/S0192415X21500816. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune and inflammatory disease with excessive loss of pancreatic islet [Formula: see text]-cells. Accumulating evidence indicated that endoplasmic reticulum (ER) stress played a critical role in [Formula: see text]-cells loss, leading to T1D. Therefore, promoting the survival of pancreatic [Formula: see text]cells would be beneficial for patients with T1D. Puerarin is a natural isoflavone that has been demonstrated to be able to decrease blood glucose in patients with T1D. However, it remains unkno...
Source: The American Journal of Chinese Medicine - September 7, 2021 Category: Complementary Medicine Authors: Xiaobo Hu Tingting Duan Zhuan Wu Cifei Tang Zhaohui Cao Source Type: research

Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action
Am J Chin Med. 2021 Sep 6:1-22. doi: 10.1142/S0192415X21500762. Online ahead of print.ABSTRACTBerberine is an alkaloid from several medicinal plants originally used to treat diarrhea and dysentery as a traditional Chinese herbal medicine. In recent years, berberine has been discovered to exhibit a wide spectrum of biological activities in the treatment of diverse diseases ranging from cancer and neurological dysfunctions to metabolic disorders and heart diseases. This review article summarizes the clinical practice and laboratory exploration of berberine for the treatment of cardiometabolic and heart diseases, with a focus...
Source: The American Journal of Chinese Medicine - September 7, 2021 Category: Complementary Medicine Authors: Richard Y Cao Yuntao Zheng Ying Zhang Lingling Jiang Qing Li Wanqun Sun Wenqin Gu Weifeng Cao Linyan Zhou Hongchao Zheng Jian Yang Source Type: research

Analysis of Gut Microbiota Composition in Lung Adenocarcinoma Patients with TCM Qi-Yin Deficiency
This study aimed to investigate the diversity and composition of gut microbiota in ADC patients with QY syndrome. 90 stool samples, including 30 healthy individuals (H), 30 ADC patients with QY syndrome, and 30 ADC patients with another syndrome (O) were collected. Then, 16s-RNA sequencing was used to analyze stool samples to clarify the structure of gut microbiota, and linear discriminant analysis (LDA) effect size (LEfSe) was applied to identify biomarkers for ADC with QY syndrome. Logistic regression analysis was performed to establish a diagnostic model for the diagnosis of QY syndrome in ADC patients, which was assess...
Source: The American Journal of Chinese Medicine - September 7, 2021 Category: Complementary Medicine Authors: Jiabin Chen Sheng Wang Jianfei Shen Qinqin Hu Yongjun Zhang Dehua Ma Kequn Chai Source Type: research

Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway
In this study, we showed that pretreatment with cordycepin significantly attenuated palmitic acid (PA)-induced cytotoxicity, reactive oxygen species (ROS) generation, and inflammatory responses. We found that PA decreased phosphorylation of Akt, eNOS, and bioavailability of nitric oxide (NO), which in turn activated NF-[Formula: see text]B and the downstream inflammatory responses. All these detrimental events were markedly blocked by pretreatment with cordycepin. Moreover, cordycepin ameliorated destabilization of mitochondrial permeability, cytosolic calcium rises, and apoptotic features caused by PA. In addition, all th...
Source: The American Journal of Chinese Medicine - September 7, 2021 Category: Complementary Medicine Authors: Chang-Wen Ku Tsung-Jung Ho Chih-Yang Huang Pei-Ming Chu Hsiu-Chung Ou Pei-Ling Hsieh Source Type: research