Clinopodium chinense Attenuates Palmitic Acid-Induced Vascular Endothelial Inflammation and Insulin Resistance through TLR4-Mediated NF- κ B and MAPK Pathways.
Clinopodium chinense Attenuates Palmitic Acid-Induced Vascular Endothelial Inflammation and Insulin Resistance through TLR4-Mediated NF- κ B and MAPK Pathways. Am J Chin Med. 2019;47(1):97-117 Authors: Shi X, Wang S, Luan H, Tuerhong D, Lin Y, Liang J, Xiong Y, Rui L, Wu F Abstract Elevated palmitic acid (PA) levels are associated with the development of inflammation, insulin resistance (IR) and endothelial dysfunction. Clinopodium chinense (Benth.) O. Kuntze has been shown to lower blood glucose and attenuate high glucose-induced vascular endothelial cells injury. In the present study we invest...
Source: The American Journal of Chinese Medicine - February 20, 2019 Category: Complementary Medicine Authors: Shi X, Wang S, Luan H, Tuerhong D, Lin Y, Liang J, Xiong Y, Rui L, Wu F Tags: Am J Chin Med Source Type: research

Casticin Promotes Immune Responses, Enhances Macrophage and NK Cell Activities, and Increases Survival Rates of Leukemia BALB/c Mice.
Abstract Casticin, derived from Fructus Viticis, has anticancer properties in many human cancer cells, however, there is no report to show that casticin promotes immune responses and affects the survival rate of leukemia mice in vivo. The aim of this study is to evaluate the effects of casticin on immune responses and the survival rate of WEHI-3 cells generated in leukemia mice in vivo. Animals were divided into six groups: normal control mice, leukemia control mice, mice treated with ATRA (all-trans retinoic acid), and casticin (0.1, 0.2, and 0.4 mg/kg) treated mice. All animals were treated for 14 days and then ...
Source: The American Journal of Chinese Medicine - January 10, 2019 Category: Complementary Medicine Authors: Lai KC, Lu HF, Chen KB, Hsueh SC, Chung JG, Huang WW, Chen CC, Shang HS Tags: Am J Chin Med Source Type: research

Suppressive Effects of Ginsenoside Rh1 on HMGB1-Mediated Septic Responses.
We examined the effects of ginsenoside Rh1 on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis. Ginsenoside-Rh1 was administered after the HMGB1 challenge. The antiseptic activity of ginsenoside Rh1 was determined by measuring the permeability, leukocyte adhesion and migration, activation of pro-inflammatory proteins in HMGB1-activated human umbilical vein endothelial cells (HUVECs) and mice, and the survival rate in a sepsis mouse model. Ginsenoside Rh1 significantly reduced HMGB1 release in lipopolysaccharide (LPS)-activated HUVECs. Furthermore, ginsenoside Rh1 suppressed the production of tum...
Source: The American Journal of Chinese Medicine - January 10, 2019 Category: Complementary Medicine Authors: Lee W, Cho SH, Kim JE, Lee C, Lee JH, Baek MC, Song GY, Bae JS Tags: Am J Chin Med Source Type: research

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.
This study may have therapeutic implication in polyQ-mediated disorders. PMID: 30612452 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Chen IC, Chang CN, Chen WL, Lin TH, Chao CY, Lin CH, Lin HY, Cheng ML, Chiang MC, Lin JY, Wu YR, Lee-Chen GJ, Chen CM Tags: Am J Chin Med Source Type: research

Anticolitic Effect of Viscum coloratum through Suppression of Mast Cell Activation.
In conclusion, VCE exerts anticolitic action through inhibiting the activation of mast cells. Therefore, VCE may be useful as a phytomedicine or functional food for inflammatory bowel disease. PMID: 30612453 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Yoo JM, Park KI, Ma JY Tags: Am J Chin Med Source Type: research

Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways.
Abstract The aim of this study was to investigate the effects of bufalin on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro. Bufalin is a cardiotonic steroid and a key active ingredient of the Chinese medicine ChanSu. The extracts of Chansu are used for various cancer treatments in China. In the present study, bufalin induced cell morphological changes, decreased total cell viability and induced G2/M phase arrest of cell cycle in NPC-TW 076 cells. Results also indicated that bufalin induced chromatin condensation (cell apoptosis) and DNA damage by DAPI staining and comet assay, respectively. The induced a...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Su EY, Chu YL, Chueh FS, Ma YS, Peng SF, Huang WW, Liao CL, Huang AC, Chung JG Tags: Am J Chin Med Source Type: research

A Guideline for Randomized Controlled Trials of Acupuncture.
Abstract Guidelines for clinical trials of acupuncture are scarce, particularly in their guidance on choosing an adequate control in an acupuncture trial. This guideline was developed to address the research methodology for clinical research in acupuncture which contains the essential elements to be considered in the design, preparation and reporting of an acupuncture RCT. Particularly, investigators focused on the control design because of the unique feature of acupuncture. As one size does not fit all, one single design cannot answer all research questions. Therefore, we recommend that the clinical questions be ...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Chen H, Yang M, Ning Z, Lam WL, Zhao YK, Yeung WF, Ng BF, Ziea ET, Lao L Tags: Am J Chin Med Source Type: research

Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.
This study assessed the anti-apoptotic effects of the administration of ferulic acid (FrA) in rats 30 min before middle cerebral artery occlusion (MCAo) followed by 3 d of ischemia and the involvement of 70 kDa heat shock protein (HSP70)-mediated signaling in the penumbral cortex. Our results demonstrated that FrA pretreatment at doses of 80 mg/kg (FrA-80 mg) and 100 mg/kg (FrA-100 mg) effectively ameliorated neurological functions and reduced the numbers of cytochrome c-, cleaved caspase-3-, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells in the penumbral cortex 3 d after ischemia. ...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Cheng CY, Kao ST, Lee YC Tags: Am J Chin Med Source Type: research

Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.
Abstract Puerarin is an isoflavonoid isolated from the root of Pueraria lobata (Gegen in Chinese) that has been widely used to treat cardiovascular and cerebrovascular diseases in China. Here, we investigated the hypotensive effects and mechanisms of puerarin in spontaneously hypertensive rats. The qPCR array technique was used to determine the expression of hypertension-related genes. Then, the differentially expressed genes were analyzed using the STRING database. The systolic blood pressure and diastolic blood pressure of rats decreased after the administration of puerarin for nine weeks. Puerarin, but not losa...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Shi W, Yuan R, Chen X, Xin Q, Wang Y, Shang X, Cong W, Chen K Tags: Am J Chin Med Source Type: research

In Vitro and In Vivo Protective Effects of Flavonoid-Enriched Lotus Seedpod Extract on Lipopolysaccharide-Induced Hepatic Inflammation.
Abstract Endotoxin lipopolysaccharide (LPS) plays an important role in the acceleration of hepatic inflammation. Natural medicinal plants that can prevent inflammation by targeting LPS have potential therapeutic clinical application. The aim of the study is to examine the anti-inflammatory effects of lotus seedpod extract (LSE), used as a traditional Chinese herbal medicine with hemostasis function and for eliminating bruise, on the LPS-induced hepatic inflammation and its underlying molecular mechanisms in vitro and in vivo. In vitro, LSE and its purified compound (-)-epigallocatechin (EGC) dose-dependently inhib...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Tseng HC, Tsai PM, Chou YH, Lee YC, Lin HH, Chen JH Tags: Am J Chin Med Source Type: research

Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.
This study aimed to evaluate the anti-inflammatory effects of rhein on gouty arthritis. Rhein within the physiological levels of humans showed no toxicity on the cell viability and differentiation, but significantly decreased the production of IL-1 β , TNF- α and caspase-1 protease in urate crystal-activated macrophages. Compared to medium controls, rhein at the therapeutic concentration (2.5 μ g/mL) effectively inhibited IL-1 β production by 47% ( P=0.002 ). Rhein did not affect the mRNA levels of CASP1, NLRP3 and ASC, but suppressed the protein expression and enzyme activity of caspase-1. Immunofluores...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Chang WC, Chu MT, Hsu CY, Wu YJ, Lee JY, Chen TJ, Chung WH, Chen DY, Hung SI Tags: Am J Chin Med Source Type: research

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.
Abstract Inflammatory bowel disease (IBD) is a group of autoimmune diseases, including ulcerative colitis and Crohn's disease, characterized by nonspecific inflammation in the gut. Total glycoside of peony (TGP) has been widely used for treatment of autoimmune diseases because of its pharmacological effects. However, it is lack of depth in whether TGP regulate T helper 17 cell (Th17) / T regulatory cell (Treg) immune balance or interleukin 23 (IL-23) / IL-17 axis to achieve the goal of treating IBD. Hence, the aim of this study was to investigate the effects of TGP on experimental colitis mice and the related mech...
Source: The American Journal of Chinese Medicine - January 7, 2019 Category: Complementary Medicine Authors: Li Q, Shan Q, Sang X, Zhu R, Chen X, Cao G Tags: Am J Chin Med Source Type: research

High-Throughput Electrophysiology Screen Revealed Cardiotoxicity of Strychnine by Selectively Targeting hERG Channel.
This study established and applied an integrated platform anchored on automatic patch clamp system to screen and evaluate a collection of CHM extracts, compositions and monomeric compounds for in vitro cardiac toxicity. Of 1036 CHM samples screened, 2.79% significantly inhibited hERG channel activity. Among them, Strychnine was identified for the first time as a potent hERG inhibitor with an IC 50 of 6.65±1.04μ M in comparison to that of Dofetilide at 1.80±0.24μ M and Quinidine at 7.42±0.54μ M. Langendorff-perfusion experiments confirmed that strychnine increased QT interphase from 71.69&plusm...
Source: The American Journal of Chinese Medicine - December 14, 2018 Category: Complementary Medicine Authors: Wang T, Chen X, Yu J, Du Q, Zhu J, Yang M, Wu H, Wang M, Zhu Y Tags: Am J Chin Med Source Type: research

Polydatin Attenuates Atherosclerosis in ApoE - ∕- Mice through PBEF Mediated Reduction of Cholesterol Deposition.
In conclusion, Polydatin relieves atherosclerosis injury in ApoE -∕- mice, mainly through down-regulation of PBEF and inhibition of PBEF-inducing cholesterol deposits in macrophages. PMID: 30537866 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - December 11, 2018 Category: Complementary Medicine Authors: Huang Z, Tian G, Cheng S, Zhao D, Zhang Y, Jia Y, Zhou F Tags: Am J Chin Med Source Type: research

Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From Pueraria lobata.
Abstract Diabetes mellitus (DM) has become one of the most challenging public health problems globally. The increasing prevalence and mortality rates call for more effective therapeutic agents, especially for DM complications. Traditional herbs have a long clinical application history for DM treatment. Puerarin is a natural isoflavone from Pueraria lobata (Wild.) Ohwi which has been consumed both as a functional food and herb in Eastern Asia countries. Documented data has shown that puerarin has cardio-protective, neuroprotective, anti-oxidative, anti-inflammatory and many other effects. In this review, we will su...
Source: The American Journal of Chinese Medicine - December 10, 2018 Category: Complementary Medicine Authors: Chen X, Yu J, Shi J Tags: Am J Chin Med Source Type: research

Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 α Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism.
Ginsenoside Rg3 Decreases NHE1 Expression via Inhibiting EGF-EGFR-ERK1/2-HIF-1 α Pathway in Hepatocellular Carcinoma: A Novel Antitumor Mechanism. Am J Chin Med. 2018 Dec 10;:1-17 Authors: Li X, Tsauo J, Geng C, Zhao H, Lei X, Li X Abstract Na + /H + exchanger 1 (NHE1) plays a vital role in the oncogenesis and development of hepatocellular carcinoma (HCC) and has been regarded as a promising target for the treatment of HCC. Ginsenoside Rg3 (Rg3), a bioactive ginseng compound, is suggested to possess pleiotropic antitumor effects on HCC. However, the underlying mechanisms of Rg3 suppressing HCC r...
Source: The American Journal of Chinese Medicine - December 10, 2018 Category: Complementary Medicine Authors: Li X, Tsauo J, Geng C, Zhao H, Lei X, Li X Tags: Am J Chin Med Source Type: research

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease.
Abstract Cardio/cerebral-vascular diseases seriously threaten human health and are the leading cause of death. As such, there is great interest in identifying a potential mechanism that controls the development process of cardio/cerebral vascular diseases. Present studies demonstrate that inflammasomes play an important role in the process of ischemic cardio/cerebral vascular diseases (ICCVDs). Among the pathological process of ICCVDs, inflammasomes activated the sterile inflammatory response that accelerated the development of diseases and aggravated the acute lesion of tissue. As the most thoroughly studied infl...
Source: The American Journal of Chinese Medicine - December 10, 2018 Category: Complementary Medicine Authors: Li Y, Liu Y, Yan X, Liu Q, Zhao YH, Wang DW Tags: Am J Chin Med Source Type: research

M2C Polarization by Baicalin Enhances Efferocytosis via Upregulation of MERTK Receptor.
In this study, we characterized that murine bone marrow derived macrophages induced by M-CSF can be further polarized into M2C phenotype by baicalin. The signatures of M2C macrophages for mRNA expression like interferon regulatory factor 4 (IRF4), interleukin-10 (IL-10), MERTK and PTX3 were up-regulated. Moreover, we observed the concomitantly decreasing of tumor necrosis factor alpha (TNF- α ), interferon regulatory factor 5 (IRF5), IL-6. In contrast, M2 macrophages polarized by IL-4 increased gene transcript of arginase-1 (Arg-1) and surface marker of CD206 indicates that their identity as M2A rather than M2C subty...
Source: The American Journal of Chinese Medicine - December 6, 2018 Category: Complementary Medicine Authors: Lai YS, Putra RBDS, Aui SP, Chang KT Tags: Am J Chin Med Source Type: research

Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation.
In conclusion, FRG can alleviate immunosuppression and inflammation by inhibiting macrophage activation and regulating Th1 and Treg cell differentiation. PMID: 30518233 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - December 6, 2018 Category: Complementary Medicine Authors: Kim JK, Kim JY, Jang SE, Choi MS, Jang HM, Yoo HH, Kim DH Tags: Am J Chin Med Source Type: research

Calotropis gigantea Promotes Neuritogenesis and Synaptogenesis through Activation of NGF-TrkA-Erk1/2 Signaling in Rat Hippocampal Neurons.
In this study, we investigated the neuromodulatory effects of the ethanol extracts of C. gigantea leaves (CGE) during synaptogenesis in the late stage of neuronal development and during early stage neuritogenesis in cultured rat hippocampal neurons. Maximum neuritogenic activity was achieved at a CGE concentration of 7.5 μ g/ml. At this concentration, CGE facilitated the early development of cytoarchitecture, as evidenced by increases in morphometric parameters, such as, the numbers, lengths, and number of branches of initial neurites, axon and dendrites. During the synaptogenic stage (DIV 14), immunocytochemistry (ICC)...
Source: The American Journal of Chinese Medicine - December 6, 2018 Category: Complementary Medicine Authors: Haque MN, Mohibbullah M, Hong YK, Moon IS Tags: Am J Chin Med Source Type: research

A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus.
Abstract Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhyd...
Source: The American Journal of Chinese Medicine - December 6, 2018 Category: Complementary Medicine Authors: Wei H, Liu S, Liao Y, Ma C, Wang D, Tong J, Feng J, Yi T, Zhu L Tags: Am J Chin Med Source Type: research

Oriental Herbal Medicine for Neurological Disorders in Children: An Overview of Systematic Reviews.
In conclusion, the efficacy of OHM is promising for some pediatric neurological disorders such as epilepsy and cerebral palsy. However, more high-quality evidence is needed to make clinical recommendations on OHM use. PMID: 30518236 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - December 6, 2018 Category: Complementary Medicine Authors: Lee B, Kwon CY, Chang GT Tags: Am J Chin Med Source Type: research

Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine.
Abstract Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Because of the possibilities of various clinical applications, the properties and administration of these bioactive glycosides deserve further investigation. Their promising treatment effects, however, are hindered by their poor solubility, poor stability and rapid e...
Source: The American Journal of Chinese Medicine - November 27, 2018 Category: Complementary Medicine Authors: Li L, Feng Y, Hong Y, Lin X, Shen L Tags: Am J Chin Med Source Type: research

Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation.
In this study, we investigated the effects of KRG on the progression of nonalcoholic steatohepatitis (NASH) in mice. NASH was induced by feeding a methionine- and choline-deficient high-fat or high-fat/high-sucrose diet for 6 or 13 weeks, respectively. Each diet group was also orally administered saline (group G0) or KRG extract (100, 200, or 400 mg/kg/day; groups G1, G2, and G4, respectively). KRG showed anti-inflammatory and antifibrogenic effects in the diet-induced NASH models. Furthermore, the expression levels of lipid metabolism-related genes were markedly decreased with KRG treatment in both diet-induced NASH group...
Source: The American Journal of Chinese Medicine - October 9, 2018 Category: Complementary Medicine Authors: Jeong H, Kim JW, Yang MS, Park C, Kim JH, Lim CW, Kim B Tags: Am J Chin Med Source Type: research

The Most Commonly Treated Acupuncture Indications in the United States: A Cross-Sectional Study.
In this study, we conducted a cross-sectional survey among 419 acupuncturists nation-wide to investigate the top 10 and top 99 acupuncture indications in private clinics in the United States. We found the top 10 indications to be: lower back pain, depression, anxiety, headache, arthritis, allergies, general pain, female infertility, insomnia, neck pain and frozen shoulder. Among the top 99 indications, pain represents the largest category; and mental health management, especially for mood disorders, is in greatest demand. The following popular groups are: immune system dysfunctions, gastrointestinal diseases, gynecology an...
Source: The American Journal of Chinese Medicine - October 9, 2018 Category: Complementary Medicine Authors: Wang H, Yang G, Wang S, Zheng X, Zhang W, Li Y Tags: Am J Chin Med Source Type: research

Acupuncture Application in Chronic Kidney Disease and its Potential Mechanisms.
In conclusion, acupuncture is proved to be beneficial for CKD patients. More research, however, is needed to verify the potential mechanisms. PMID: 30286626 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 6, 2018 Category: Complementary Medicine Authors: Xiong W, He FF, You RY, Xiong J, Wang YM, Zhang C, Meng XF, Su H Tags: Am J Chin Med Source Type: research

Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.
This study was conducted to investigate the potential anticancer effects and the underlying mechanisms of QYJD and its active constituents, matrine and oxymatrine, in human colon cancer HT29 cells and in a dextran sulfate sodium (DSS)-induced colitis mouse model. QYJD and matrine effectively inhibited the proliferation and anchorage-independent growth of HT29 cells in a dose-dependent manner. QYJD and matrine also induced an Nrf2-mediated anti-oxidant response element-luciferase activity and upregulated the Nrf2-mediated anti-oxidative stress genes HO-1 and NQO1 at both the mRNA and protein levels. In the DSS-induced colit...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Fang R, Wu R, Zuo Q, Yin R, Zhang C, Wang C, Guo Y, Yang AY, Li W, Lin L, Kong AN Tags: Am J Chin Med Source Type: research

Therapeutic Potential of Naringin for Intervertebral Disc Degeneration: Involvement of Autophagy Against Oxidative Stress-Induced Apoptosis in Nucleus Pulposus Cells.
In conclusion, our study suggests that naringin can protect nucleus pulposus cells against apoptosis and ameliorate IDD in vivo, the mechanism may relate to its autophagy regulation. PMID: 30284462 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Zhang Z, Wang C, Lin J, Jin H, Wang K, Yan Y, Wang J, Wu C, Nisar M, Tian N, Wang X, Zhang X Tags: Am J Chin Med Source Type: research

Progress in Experimental and Clinical Research of the Diabetic Retinopathy Treatment Using Traditional Chinese Medicine.
Abstract Diabetic retinopathy (DR), one of the most common microvascular complications of diabetic mellitus, is currently the main cause of adult-acquired blindness. The pathogenesis of DR is complex and the current clinical application of various treatment methods cannot completely prevent the development of this disease. Many reports have been published regarding the treatment of DR with Traditional Chinese Medicine (TCM), which has received increasing attention from medical practitioners worldwide. Studies published between 1994 and April 2017 were collected from the CNKI, VIP, Medline and Web of Science databa...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Xu ZH, Gao YY, Zhang HT, Ruan KF, Feng Y Tags: Am J Chin Med Source Type: research

Chinese Herbal Medicine Glycyrrhiza inflataReduces A β Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.
This study examined the neuroprotection effects of CHM extract Glycyrrhiza inflata (G. inflata) and its active constituents, licochalcone A and liquiritigenin in AD. We examined A[Formula: see text] aggregation inhibition, anti-oxidation and neuroprotection in Tet-On A[Formula: see text]-GFP 293/SH-SY5Y cells and anti-inflammatory potential in lipopolysaccharide (LPS)-stimulated RAW 264.7 and LPS and interferon (IFN)-[Formula: see text] (LPS/IFN-[Formula: see text])-activated BV-2 cells. In addition, we applied conditioned media (CM) of BV-2 cells primed with LPS/IFN-[Formula: see text] to A[Formula: see text]-GF...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Chiu YJ, Lee CM, Lin TH, Lin HY, Lee SY, Mesri M, Chang KH, Lin JY, Lee-Chen GJ, Chen CM Tags: Am J Chin Med Source Type: research

Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-[Formula: see text]B Signaling Pathway.
Abstract The cytokine C-X-C motif chemokine ligand 8 (CXCL8) is produced in the tumor microenvironment and has an important role in cancer pathogenesis. CXCL8 activates the nuclear factor (NF)-[Formula: see text]B signaling. However, the role of NF-[Formula: see text]B inactivation in apoptosis induced by negative regulation of CXCL8 remains unclear. Here, we assessed the effects of MRGX on the transcriptional activity of NF-[Formula: see text]B and the expression of tumor necrosis factor (TNF)-[Formula: see text]-stimulated target genes in liver cancer cells. Furthermore, we found that modified regular ginseng ex...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Cui ZY, Jo E, Jang HJ, Hwang IH, Lee KB, Yoo HS, Park SJ, Jung MK, Lee YW, Jang IS Tags: Am J Chin Med Source Type: research

Activity Dependent Mammalian Target of Rapamycin Pathway and Brain Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Effects of Puerarin.
Abstract Puerarin is a traditional Chinese medicine with beneficial effects of reduced depression-like behaviors in mice with stress. Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. Interestingly, BDNF and Akt downstream target, mammalian target of rapamycin (mTOR) mediate the fast-acting antidepressant properties of ketamine. Until now, the involvement of the mTOR signaling pathway or BDNF on puerarin-induced antidepressant effect remains unknown. We aimed to investigate whether the antidepressant-...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Huang CC, Tsai MH, Wu YC, Chen KT, Chuang HW, Chen Y, Tseng GW, Fu PI, Wei IH Tags: Am J Chin Med Source Type: research

Antidepressant Effects of Vaccinium bracteatum via Protection Against Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis.
Abstract The present study evaluates the anti-oxidative stress activity of Vaccinium bracteatum Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using in vitro models of hydrogen peroxide (H2O[Formula: see text]-induced neuronal damage. The results...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Oh DR, Kim Y, Choi EJ, Jo A, Shin J, Kang H, Lee SG, Kim J, Kim YR, Choi CY Tags: Am J Chin Med Source Type: research

Allyl Isothiocyanate Induces Autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells.
Abstract Allyl isothiocyanate (AITC), one of the most widely studied phytochemicals, inhibits the survival of human prostate cancer cells while minimally affecting normal prostate epithelial cells. Our study demonstrates the mechanism of AITC-induced cell death in prostate cancer cells. AITC induces autophagy in RV1 and PC3 cells, judging from the increased level of LC3-II protein in a dose- and time-dependent manner, but not in the normal prostate epithelial cell (PrEC). Inhibition of autophagy in AITC-treated cells decreased cell viability and enhanced apoptosis, suggesting that the autophagy played a protective...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Chen HE, Lin JF, Tsai TF, Lin YC, Chou KY, Hwang TI Tags: Am J Chin Med Source Type: research

Regulating Gut Flora Dysbiosis in Obese Mice by Electroacupuncture.
This study aimed to explore the impacts of electroacupuncture treatment on gut microbiota composition and function in obese mice. Pyrosequencing of 16S rRNA genes and Metagenomic analysis of the fecal microbiota were used for this purpose. The basic parameters of body weight, Lee's index, serum lipid and epididymal adipose weight were ameliorated significantly after introducing an electroacupuncture intervention. Acidobacteria, Cyanobacteria and Basidiomycota (Normal group) and Fusobacteria, Firmicutes and Spirochmycetes (Model group) were remarkably affluent at the phylum level. Bacteroides sp. CAG: 927 and Prevotella sp....
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Si YC, Miao WN, He JY, Chen L, Wang YL, Ding WJ Tags: Am J Chin Med Source Type: research

Marsdenia tenacissima: A Review of Traditional Uses, Phytochemistry and Pharmacology.
Abstract The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Nowadays, the extract of Marsdenia tenacissima, under the trademark of "Xiao-ai-ping", is widely used in clinic for the treatment of different cancers in China. To date, approximately 196 chemical ingredients covering steroids, triterpenes and organic acids have been identified from different parts of this plant. Steroids are the major char...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Wang P, Yang J, Zhu Z, Zhang X Tags: Am J Chin Med Source Type: research

Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease.
Abstract Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supp...
Source: The American Journal of Chinese Medicine - September 5, 2018 Category: Complementary Medicine Authors: Bae UJ, Park EO, Park J, Jung SJ, Ham H, Yu KW, Park YJ, Chae SW, Park BH Tags: Am J Chin Med Source Type: research

Panax notoginseng Inhibits Tumor Growth through Activating Macrophage to M1 Polarization.
Abstract Among the herbal ingredients of HangAmDan-B, a medicinal formula that redirects macrophages to become tumoricidal effectors, we found that Panax notoginseng (Burk.) F. H. Chen is the active component responsible for its macrophage-mediated antitumor activity. The water extracted roots of P. notoginseng (PN) did not affect the viability of RAW264.7 murine macrophage-like cells and murine Lewis lung carcinoma (LLC) cells up to a concentration of 100[Formula: see text][Formula: see text]g/mL. However, the transfer of culture media from PN-treated RAW264.7 cells suppressed the growth of LL...
Source: The American Journal of Chinese Medicine - August 31, 2018 Category: Complementary Medicine Authors: Kim B, Kim EY, Lee EJ, Han JH, Kwak CH, Jung YS, Lee SO, Chung TW, Ha KT Tags: Am J Chin Med Source Type: research

Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-[Formula: see text]B and Nrf2 Pathways.
Abstract Antrodia cinnamomea, a medicinal mushroom, has previously demonstrated anti-inflammatory activity, although the specific compound responsible for the effect remains unclear. The present study was designed to investigate the anti-inflammatory property of antrolone, a novel benzoid derived from A. cinnamomea mycelium, and to clarify the underlying mechanisms of action. To this end, murine macrophage RAW264.7 cells were treated with antrolone (0.1-30[Formula: see text][Formula: see text]M) 30[Formula: see text]min prior to stimulation with lipopolysaccharides (LPS, 0.1[Formula: see text][Formula: see text]g/...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Yen IC, Shi LS, Chung MC, Ahmetaj-Shala B, Chang TC, Lee SY Tags: Am J Chin Med Source Type: research

Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKK[Formula: see text]/[Formula: see text]-Mediated NF-[Formula: see text]B Pathway in Macrophages.
Abstract Lilium bulbs have long been used as Chinese traditional medicines to alleviate the symptoms of various human inflammatory diseases. However, mechanisms of Lilium bulb-mediated anti-inflammatory activity and the bioactive components in Lilium bulbs remain unknown. In the present study, the anti-inflammatory activity of Lilium bulbs and the underlying mechanism of action were investigated in macrophages using Lilium bulb ethanol extracts (Lb-EE). In a dose-dependent manner, Lb-EE inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and bone marrow-derived macrophages ...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Han SY, Yi YS, Jeong SG, Hong YH, Choi KJ, Hossain MA, Hwang H, Rho HS, Lee J, Kim JH, Cho JY Tags: Am J Chin Med Source Type: research

Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
In this study, the anti-inflammatory effect of neferine was investigated. Raw264.7 cells were stimulated with lipopolysaccharide (LPS) or LPS plus Z-VAD-fmk (Z-VAD). The inhibitory effect of neferine on secretion of nitrite, cytokines tumor necrosis factor alpha (TNF-[Formula: see text]) and interleukin 6 (IL-6), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was determined. The protective effect of neferine was investigated in dextran sulfate sodium (DSS)-induced UC mouse model. Neferine significantly inhibited LPS and LPS plus Z-VAD induced secretion of nitrite, cytokines, and expressio...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wu X, Guo Y, Min X, Pei L, Chen X Tags: Am J Chin Med Source Type: research

Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer.
Abstract Bladder cancer has a high recurrence rate and requires adjuvant intravesical management after surgery. The use of traditional agents for bladder cancer therapy is constrained by their toxicity and limited efficacy. This emphasizes the need for the development of safer, more effective compounds such as instillation agents. Curcumin is the major component of turmeric, the powdered root of Curcuma longa, which is known for its anti-inflammatory, anti-oxidant and anticancer properties. First, a microarray profiling and qPCR analysis were conducted in the T24 and SV-HUC-1 cell lines. Then, we examined the pote...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wang K, Tan SL, Lu Q, Xu R, Cao J, Wu SQ, Wang YH, Zhao XK, Zhong ZH Tags: Am J Chin Med Source Type: research

Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition.
This study investigated whether a 30% ethanolic SP extract (SPEtOH) and its constituents can reduce CRAC currents ([Formula: see text]), and thus inhibit mast cell degranulation and T cell activation. In Jurkat T lymphocytes, we found that 3[Formula: see text]mg/mL SPEtOH inhibited the [Formula: see text] by [Formula: see text]%, whereas one of its constituents vitexin (100[Formula: see text][Formula: see text]M) inhibited the [Formula: see text] by [Formula: see text]%. Furthermore, in the RBL-2H3 mast cell, the [Formula: see text] was inhibited by 3[Formula: see text]mg/mL SPEtOH ([Formula: see text]%) and 100[Formula: s...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Kim HJ, Nam YR, Kim EJ, Nam JH, Kim WK Tags: Am J Chin Med Source Type: research

Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.
In conclusion, Rg3 deregulated tumor-related genes through alteration of the epigenetic methylation level leading to growth inhibition of cancer cells. PMID: 30149757 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Ham J, Lee S, Lee H, Jeong D, Park S, Kim SJ Tags: Am J Chin Med Source Type: research

Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats.
In conclusion, our results indicated that MLB exerted robust neuroprotective effects against SAH via suppressing neuroinflammation and apoptosis. These neuroprotective effects of MLB against SAH might be exerted via regulating the SIRT1/NF-[Formula: see text]B pathway. MLB or the SIRT1/NF-[Formula: see text]B pathway could be a novel and promising therapeutic strategy for SAH management. PMID: 30149758 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Peng Y, He P, Fan L, Xu H, Li J, Chen T, Ruan W, Dou Z, Chen G Tags: Am J Chin Med Source Type: research

Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion.
This study investigated the ameliorating effect of scutellarin (SCT) on spatial cognitive impairment and [Formula: see text]-amyloid (A[Formula: see text]) formation in rats with chronic cerebral hypoperfusion induced by permanent bilateral common carotid artery occlusion (pBCAO). SCT is a flavonoid in medicinal herb of Erigeron breviscapus (vant.) Hand. Mazz. known to have neuroprotective, antioxidative and anti-inflammatory effects. However, the beneficial effect and pivotal mechanism of SCT on cognitive impairment are still unclear. SCT was treated orally with two doses (10 or 30[Formula: see text]mg/kg) for 4 weeks. Re...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Shin JW, Kweon KJ, Kim DK, Kim P, Jeon TD, Maeng S, Sohn NW Tags: Am J Chin Med Source Type: research

Oleanolic Acid, A Novel Endothelin a Receptor Antagonist, Alleviated High Glucose-Induced Cardiomyocytes Injury.
Abstract Endothelin-1 (ET-1) and its receptor endothelin A receptor (ET[Formula: see text] have been shown to be upregulated in a high glucose environment, which increase the incidence of diabetes-related heart failure. Our previous study demonstrated that oleanolic acid (OA), a natural compound found in Chinese herbs had ET-1 antagonistic effects. We aimed to verify whether OA could ameliorate diabetes mellitus (DM)-induced injury in cardiomyocytes by reducing the antagonistic effects of the ET-1 pathway. For the induction of high glucose-related injury in cardiomyocytes, neonatal rat ventricular cardiomyocytes (...
Source: The American Journal of Chinese Medicine - August 27, 2018 Category: Complementary Medicine Authors: Wu D, Zhang Q, Yu Y, Zhang Y, Zhang M, Liu Q, Zhang E, Li S, Song G Tags: Am J Chin Med Source Type: research

Chinese Herbal Medicine for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Abstract Chinese herbal medicine (CHM) has been widely used in the treatment of advanced non-small-cell lung cancer (NSCLC), but their efficacy and safety remain controversial. We sought to comprehensively aggregate and evaluate the available evidence on the efficacy and safety of the combination treatment with CHM and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in NSCLC patients. Our exhausted and systematical searching strategy yielded 64 related randomized controlled trials involving 4384 patients. Compared with EGFR-TKIs therapy alone, meta-analysis showed significant differences fa...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Zhang XW, Liu W, Jiang HL, Mao B Tags: Am J Chin Med Source Type: research

Administrations of Preoperative Shenmai Injection and Postoperative Shenfu Injection, Two Ginseng Containing TCM Formulas, Improve Cognitive Dysfunction in Aged Rats.
Abstract Postoperative cognitive dysfunction (POCD) is one of the major complications in patients who have undergone surgeries. Reduction of surgery-induced inflammation and perioperative stress responses may prevent the development of POCD. As recent experimental data have suggested, Shenmai and Shenfu injections, two ginseng containing formulations, may improve cognition. We designed this study using aged rats as an experimental model to determine the effect of combined perioperative Shenmai injection and Shenfu injection in preventing the development of POCD and exploring the underlying mechanism of this interv...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Zhang WL, Chi YL, Wang LZ, Liu H, Zhao LX, Su F Tags: Am J Chin Med Source Type: research

Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation.
Abstract Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory and debilitating disease that involves the systemic imbalance of the immune network. Previous studies have shown that acupuncture can help treat RA. However, its specific mechanisms are not fully understood. Thus, the present study was designed to clarify the mechanisms of acupuncture acted on RA via immune network modulation using complete Freund's adjuvant (CFA)-induced arthritic rats. Results revealed that manual acupuncture (MA) could alleviate the inflammation and pain of infected joints. Moreover, MA could effectively stimulate...
Source: The American Journal of Chinese Medicine - July 12, 2018 Category: Complementary Medicine Authors: Xu Y, Hong S, Zhao X, Wang S, Xu Z, Ding S, Zhang K, Zhang Y, Xu L, Yu N, Zhao T, Yan Y, Yang F, Liu Y, Yu K, Liu B, Guo Y, Pang G Tags: Am J Chin Med Source Type: research