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Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research

Natural Products in the Modulation of Farnesoid X Receptor Against Nonalcoholic Fatty Liver Disease
Am J Chin Med. 2024 Mar 14:1-24. doi: 10.1142/S0192415X24500137. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a global health concern with a high prevalence and increasing economic burden, but official medicine remains unavailable. Farnesoid X receptor (FXR), a nuclear receptor member, is one of the most promising drug targets for NAFLD therapy that plays a crucial role in modulating bile acid, glucose, and lipid homeostasis, as well as inhibits hepatic inflammation and fibrosis. However, the rejection of the FXR agonist, obecholic acid, by the Food and Drug Administration for treating hepatic ...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Jing Wang Na Yang Yu Xu Source Type: research

Apigenin Suppresses Innate Immune Responses and Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of STING/IRF3 Pathway
Am J Chin Med. 2024 Mar 14:1-22. doi: 10.1142/S0192415X24500204. Online ahead of print.ABSTRACTThe stimulator of interferon genes (STING) signaling pathway is crucial for the pathogenesis of autoimmune and inflammatory disorders, including acute lung injury (ALI). Apigenin (4[Formula: see text],5,7-trihydroxyflavone) is a natural flavonoid widely found in fruits, vegetables, and Chinese medicinal herbs that exhibits a range of pharmacological effects, such as antibacterial and anti-inflammatory activities. However, the efficacy of apigenin in STING pathway-mediated diseases remains unclear. Accordingly, this study screened...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Xu-Wei Zhou Juan Wang Wen-Fu Tan Source Type: research

Eugenol Possesses Colitis Protective Effects: Impacts on the TLR4/MyD88/NF-[Formula: see text]B Pathway, Intestinal Epithelial Barrier, and Macrophage Polarization
In this study, DSS-induced acute colitis was established and applied to clarify the regulation efficacy of EU on intestinal barrier impairment and macrophage polarization imbalance along with the inflammatory response. Besides, the adjusting effect of EU on macrophages was further investigated in vitro. The results confirmed that EU intervention alleviated DSS-induced colitis through methods such as restraining weight loss and colonic shortening and decreasing DAI scores. Microscopic observation manifested that EU maintained the intestinal barrier integrity in line with the mucus barrier and tight junction protection. Furt...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Jun-Jie Huang Yue-Min Feng Shu-Mei Zheng Cheng-Long Yu Rui-Gang Zhou Ming-Jiang Liu Ruo-Nan Bo Jie Yu Jin-Gui Li Source Type: research

Red Yeast Rice and Statin Therapy in Patients with Hypercholesterolemia and the Comorbidities: A Retrospective Cohort Study on Lipid-Lowering Effects and Cardiovascular Outcomes
In conclusion, both RYR and statins effectively lower blood lipid levels and mitigate related complications. Combining these therapies may lead to fewer ER visits, reduced stroke frequency, and fewer MI hospitalizations in hypertensive and kidney disease patients, and they decreased all-cause mortality in the kidney disease population. Further research on combined therapy is warranted.PMID:38480501 | DOI:10.1142/S0192415X24500174 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Tun-Pin Hsueh Wan-Ling Lin Wen-Long Hu Yu-Chiang Hung Source Type: research

Curcumin Analog L48H37 Induces Apoptosis in Human Oral Cancer Cells by Activating Caspase Cascades and Downregulating the Inhibitor of Apoptosis Proteins through JNK/p38 Signaling
Am J Chin Med. 2024 Mar 14:1-17. doi: 10.1142/S0192415X24500241. Online ahead of print.ABSTRACTL48H37 is a synthetic curcumin analog that has anticancer potentials. Here, we further explored the anticancer effect of L48H37 on oral cancer cells and its mechanistic acts. Cell cycle distribution was assessed using flow cytometric analysis. Apoptosis was elucidated by staining with PI/Annexin V and activation of the caspase cascade. Cellular signaling was explored using apoptotic protein profiling, Western blotting, and specific inhibitors. Our findings showed that L48H37 significantly reduced the cell viability of SCC-9 and H...
Source: The American Journal of Chinese Medicine - March 14, 2024 Category: Complementary Medicine Authors: Chun-Wen Su Shao-Hsuan Kao Yi-Tzu Chen Yi-Hsien Hsieh Wei-En Yang Meng-Ying Tsai Chiao-Wen Lin Shun-Fa Yang Source Type: research

Mechanism of Acupuncture in Treating Obesity: Advances and Prospects
Am J Chin Med. 2024;52(1):1-33. doi: 10.1142/S0192415X24500010. Epub 2024 Feb 8.ABSTRACTObesity is a common metabolic syndrome that causes a significant burden on individuals and society. Conventional therapies include lifestyle interventions, bariatric surgery, and pharmacological therapies, which are not effective and have a high risk of adverse events. Acupuncture is an effective alternative for obesity, it modulates the hypothalamus, sympathetic activity and parasympathetic activity, obesity-related hormones (leptin, ghrelin, insulin, and CCK), the brain-gut axis, inflammatory status, adipose tissue browning, muscle bl...
Source: The American Journal of Chinese Medicine - February 14, 2024 Category: Complementary Medicine Authors: Mi-Na Wang Miao-Xin Zhai Yi-Tong Wang Qiu-Fu Dai Lu Liu Luo-Peng Zhao Qiu-Yu Xia Shen Li Bin Li Source Type: research