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Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research

Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research

Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research

Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research

Components from < em > Curcuma longa < /em > (Turmeric) Against Hepatobiliary Diseases Based on Gut-Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications
Am J Chin Med. 2024 Mar 16:1-29. doi: 10.1142/S0192415X24500162. Online ahead of print.ABSTRACTTurmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut-liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms to its effects on liver and biliary diseases to explain the potential mechanism of turmeric's regulation of the gut-liver axis. Beside...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Tianhui Gao Shuyi Wang Zongping Zhu Liting Lin Yirong Luo Meigui Lu Wan Liao Source Type: research

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway
Am J Chin Med. 2024 Mar 16:1-17. doi: 10.1142/S0192415X24500198. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DO...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Wencong Tian Ping Zhang Lei Yang Peng Song Jia Zhao Hongzhi Wang Yongjie Zhao Lei Cao Source Type: research

Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma
This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma through both in vivo and in vitro methods. Our research revealed that quercetin has the ability to boost antitumor immunity by modulating the tumor immune microenvironment through increasing the percentages of M1 macrophages, CD8[Formula: see text] T lymphocytes, and CD4[Formula: see text] T lymphocytes and promoting the secretion of IL-2 and IFN-[Formula: see text] from CD8[Formula: see text] T cells, consequently suppressing the growth of melanoma. Furthermore, we revealed that quercetin can inhibit cell proli...
Source: The American Journal of Chinese Medicine - March 15, 2024 Category: Complementary Medicine Authors: Xin Li Xue He Bing Lin Li Li Qifeng Deng Chengzhi Wang Jing Zhang Ying Chen Jingyi Zhao Xinrui Li Yan Li Qing Xi Rongxin Zhang Source Type: research