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Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway
This study aims to explore the effects of WG on the radioresistance of breast cancer. Our results indicate that Nrf2 and HIF-1[Formula: see text] overexpression was observed in breast cancer tissues and was correlated with the histological grading of the disease. Radiation further increased the levels of Nrf2 and HIF-1[Formula: see text] in breast cancer cells. However, WG demonstrated the ability to induce cell apoptosis and reverse radioresistance by inhibiting the Nrf2/HIF-1[Formula: see text] pathway. These effects were also confirmed in xenograft mice models. Mechanistically, WG enhanced the level of the Nrf2 inhibito...
Source: The American Journal of Chinese Medicine - October 30, 2023 Category: Complementary Medicine Authors: Ting Wang Pinghan Wang Song Wang Yu Ma Ziqiao Zhao Fangyi Long Source Type: research

A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of < em > Ganoderma < /em >
Am J Chin Med. 2023 Oct 31:1-58. doi: 10.1142/S0192415X23500878. Online ahead of print.ABSTRACTGanoderma is the dried fruiting bodiy of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang, belonging to the family Polyporaceae, which grows mainly in tropical, subtropical, and temperate regions. As a traditional Chinese medicine, Ganoderma has been used in China for more than 2000 years because of its medicinal properties, such as relieving cough and asthma, providing nourishment, and strengthening. Currently, more than 470 natural compounds have been obtained from the fungus, mainly including terp...
Source: The American Journal of Chinese Medicine - October 30, 2023 Category: Complementary Medicine Authors: Chenwang Liu Xiaomei Song Yuze Li Chao Ding Xin Li Linwei Dan Haonan Xu Dongdong Zhang Source Type: research

Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome
Am J Chin Med. 2023 Oct 27:1-25. doi: 10.1142/S0192415X23500866. Online ahead of print.ABSTRACTThe gut microbiome (GM) has become a crucial factor that can affect the progression of osteoporosis. A number of studies have demonstrated the impact of Traditional Chinese Medicine (TCM) on GM and bone metabolism. In this review, we summarize the potential mechanisms of the relationship between osteoporosis and GM disorder and introduce several natural Chinese medicines that exert anti-osteoporosis effects by modulating the GM. It is underlined that, through the provision of the microbial associated molecular pattern (MAMP), the...
Source: The American Journal of Chinese Medicine - October 26, 2023 Category: Complementary Medicine Authors: Kun Li Yiping Jiang Nani Wang Liyong Lai Shengyan Xu Tianshuang Xia Xiaoqiang Yue Hailiang Xin Source Type: research

β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity
Am J Chin Med. 2023 Oct 20:1-26. doi: 10.1142/S0192415X23500908. Online ahead of print.ABSTRACT[Formula: see text]-Escin is an oleanane-type pentacyclic triterpenoid saponin extracted from the seeds of Aesculus hippocastanum (AH), which is more widely distributed. [Formula: see text]-Escin sodium has been approved by the American FDA for clinical usage. This paper is intended to summarize an updated and comprehensive review of the pharmacological activities, pharmacokinetic properties, toxicity, and analytical methods of [Formula: see text]-escin. Studies have shown that [Formula: see text]-escin has significant antitumor,...
Source: The American Journal of Chinese Medicine - October 22, 2023 Category: Complementary Medicine Authors: Yunyu Wang Xiuwei Han Xinhuan Wan Fengjv Niu Changzheng Zhou Source Type: research

Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-[Formula: see text]B Signaling Pathway
In conclusion, PA-pretreatment ameliorates HS-induced cardiac injury, potentially through its inhibition of the NF-[Formula: see text]B pathway. Therefore, PA treatment holds promise as a strategy for mitigating cardiac damage in HS.PMID:37865871 | DOI:10.1142/S0192415X23500921 (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - October 22, 2023 Category: Complementary Medicine Authors: Zhenfeng Liu Wuming Zhou Qingyang Liu Zhirong Huan Qiubo Wang Xin Ge Source Type: research