Humulus scandens Exhibits Immunosuppressive Effects in Vitro and in Vivo by Suppressing CD4(+) T Cell Activation.
In this study, the major active faction of Humulus scandens (H.S) was prepared. Then, its immunosuppressive effects and underlying mechanisms on T cell activation were investigated in vitro and in vivo. Results showed that H.S significantly inhibited the proliferation of splenocytes induced by concanavalin A, lipopolysaccharides, and mixed-lymphocyte reaction in vitro. Additionally, H.S could dramatically suppress the proliferation and interferon-γ (IFN-γ) production from T cells stimulated by anti-CD3 and anti-CD28. Flow cytometric results confirmed that H.S could suppress the differentiation of IFN-γ-pr...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Feng J, Wu Y, Yang Y, Jiang W, Hu S, Li Y, Yang Y Tags: Am J Chin Med Source Type: research

Suppressive effects of britanin, a sesquiterpene compound isolated from inulae flos, on mast cell-mediated inflammatory responses.
Abstract Mast cells are central players in immediate-type hypersensitvity and inflammatory responses. In the present study, the effects of britanin on the passive cutaneous anaphylaxis (PCA) reaction in mice and on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced production of pro-inflammatory cytokines in human mast cell line (HMC-1) were evaluated. The oral administration of britanin (10-20 mg/kg) decreased the mast cell-mediated PCA reaction in IgE-sensitized mice. In the activity and mechanism of britanin in vitro assay, britanin suppressed the gene expression and secretion of p...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Park HH, Kim SG, Park YN, Lee J, Lee YJ, Park NY, Jeong KT, Lee E Tags: Am J Chin Med Source Type: research

Millettia pachycarpa Exhibits Anti-Inflammatory Activity Through the Suppression of LPS-Induced NO/iNOS Expression.
Abstract The present study was designed to investigate the in vitro and in vivo anti-inflammatory activity of flavonoids isolated from Millettia pachycarpa Benth. The seeds of M. pachycarpa Benth were extracted with ethanol and subjected to chromatographic separation for the isolation of bioactive compounds. Their structures were elucidated by spectroscopic methods. The anti-inflammatory activity of the compounds was investigated by evaluating the inhibition ability of NO production, iNOS activity and iNOS protein expression induced by LPS-stimulated RAW264.7 macrophages in vitro and the carrageenan-induced hind p...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Ye H, Xie C, Wu W, Xiang M, Liu Z, Li Y, Tang M, Li S, Yang J, Tang H, Chen K, Long C, Peng A, Chen L Tags: Am J Chin Med Source Type: research

Salvia plebeia Suppresses Atopic Dermatitis-Like Skin Lesions.
In this study, we investigated the effects of S. plebeia extract (SPE) on atopic dermatitis (AD)-like skin lesions and defined underlying mechanisms of action. We established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) to the ears. Repeated alternative treatment of DFE/DNCB caused AD-like skin lesions. The oral administration of SPE decreased AD symptoms based on ear thickness and histopathological analysis, in addition to serum IgE and IgG2a levels. SPE suppressed mast cell infiltration into the ear and serum h...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Choi JK, Oh HM, Lee S, Kwon TK, Shin TY, Rho MC, Kim SH Tags: Am J Chin Med Source Type: research

Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix Improve Age-Related Oxidative Stress and Inflammatory Response through the PI3K/Akt or MAPK Pathways.
This study examined whether Kangen-karyu and its crude drug, Salviae Miltiorrhizae Radix, have a reno-protective effect on the age-related oxidative stress and inflammatory response through the phosphoinositide 3-kinase (PI3K)/Akt or mitogen-activated protein kinase (MAPK) pathways in aged rats. Kangen-karyu or Salviae Miltiorrhizae Radix (20 mg/kg body weight/day) was administered orally to old groups of rats for 16 days, and their effects were compared with the vehicle-treated old and young rats. The administration of Kangen-karyu caused a slight decrease in the serum glucose level and a significant decrease in the serum...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Park CH, Kim DH, Park MH, Kim MK, Kim ND, Kim CM, Tanaka T, Yokozawa T, Chung HY, Moon HR Tags: Am J Chin Med Source Type: research

Gastrodia elata Shows Neuroprotective Effects via Activation of PI3K Signaling against Oxidative Glutamate Toxicity in HT22 Cells.
Abstract Dried roots of Gastrodia elata have traditionally been used in Korean medicine for the treatment of neurological disorders such as scotodinia, paralysis, and epilepsy. In our study, we attempted to investigate the neuroprotective effects of methanol extract from G. elata (MEGE) against glutamate-mediated oxidative stress and to explore underlying neuroprotective mechanisms. Analyses for cell viability, lactate dehydrogenase (LDH), flow cytometry, Western blot, and reactive oxygen species (ROS) were performed in HT22 hippocampal cells. Pretreatment with MEGE resulted in a potent neuroprotective effect agai...
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Han YJ, Je JH, Kim SH, Ahn SM, Kim HN, Kim YR, Choi YW, Shin HK, Choi BT Tags: Am J Chin Med Source Type: research

Angelica sinensis Induces Hair Regrowth via the Inhibition of Apoptosis Signaling.
Abstract Hair loss is accompanied by keratinocyte apoptosis-regression during catagen and prolonged telogen. Angelica sinensis was reported to promote hair growth in vitro. Based on previous studies, we explored the hair growth effect and the mechanism of A. sinensis related to keratinocyte apoptosis-regression during catagen in mice. The 70% Ethanol extract of A. sinensis was applied topically at doses of 1 and 100 mg/mL to the dorsa of C57BL/6 mice for 2 weeks. The A. sinensis-treated group showed noticeable hair regrowth. Treatment with A. sinensis restored the lengths of hair shafts and size of hair follicles....
Source: The American Journal of Chinese Medicine - July 12, 2014 Category: Complementary Medicine Authors: Kim MH, Choi YY, Cho IH, Hong J, Kim SH, Yang WM Tags: Am J Chin Med Source Type: research

A systematic review on natural medicines for the prevention and treatment of Alzheimer's disease with meta-analyses of intervention effect of ginkgo.
Abstract We performed a systematic review to evaluate the efficacy of natural medicines for the treatment of Alzheimer's disease (AD) in randomized controlled trials (RCTs). Disease-specific and intervention terms were searched in MEDLINE, EMBASE, the Cochrane Library and PsycINFO to identify RCTs for the AD intervention of natural medicines, and searched for literatures in English language. The RCTs compared natural medicines and either placebo or orthodox medication in AD patients. The quality of literature was evaluated by Jadad's score and the Cochrane assessing tool to reduce the risk of bias. Meta-analysis a...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Yang M, Xu DD, Zhang Y, Liu X, Hoeven R, Cho WC Tags: Am J Chin Med Source Type: research

Platycladus orientalis Leaves: A Systemic Review on Botany, Phytochemistry and Pharmacology.
Abstract Platycladus orientalis leaves (Cebaiye) have been used for thousands of years as traditional Chinese medicine (TCM). According to the theory of TCM, they are categorized as a blood-cooling and hematostatic herb. In clinical practice, they were usually prescribed with heat-clearing herbs to reinforce the efficacy of hemostasis. The review provides the up-to-date information from 1980 to present that is available on the botany, processing research, phytochemistry, pharmacology and toxicology of the leaves. The information is collected from scientific journals, books, theses and reports via library and elect...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Shan MQ, Shang J, Ding AW Tags: Am J Chin Med Source Type: research

Traditional chinese medicine: a treasured natural resource of anticancer drug research and development.
Abstract To discover and develop novel natural compounds, active ingredients, single herbs and combination formulas or prescriptions in traditional Chinese medicine (TCM) with therapeutic selectivity that can preferentially kill cancer cells and inhibit the amplification of cancer without significant toxicity is an important area in cancer therapy. A lot of valuable TCMs were applied as alternative or complementary medicines in the United States and Europe. But these TCMs, as one of the main natural resources, were widely used to research and develop new drugs in Asia. In TCMs, some specific herbs, animals, minera...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Wang CY, Bai XY, Wang CH Tags: Am J Chin Med Source Type: research

Effect of cantharidins in chemotherapy for hepatoma: a retrospective cohort study.
This study aimed to evaluate the effects of cantharidins, a traditional Chinese medicine, in chemotherapy for the treatment of hepatoma. From August 2011 to December 2012, 96 patients with hepatoma, who were eligible for transcatheter hepatic arterial chemoembolization and received cantharidins, were selected for comparison with the control group of 95 patients without cantharidins. The treatment effect, clinical symptoms and adverse effects were analyzed. The results of the study showed that the cantharidins group had a higher overall efficient rate than the control group (p
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Zhang W, Ma YZ, Song L, Wang CH, Qi TG, Shao GR Tags: Am J Chin Med Source Type: research

Clinical efficacy of acupuncture as an adjunct to methadone treatment services for heroin addicts: a randomized controlled trial.
Abstract Scant scientific evidence supports the efficacy of acupuncture in the treatment of opiate dependence. The purpose of this study was to examine the effectiveness of acupuncture for heroin addicts on methadone maintenance by measuring the daily consumption of methadone, variations in the 36-item Short Form Health Survey-36 (SF-36) and Pittsburgh Sleep Quality Index (PSQI) scores, and heroin craving. Sixty heroin addicts were randomly assigned to true acupuncture (electroacupuncture at the Hegu [LI4] and Zusanli [ST36] acupoints, as well as acupuncture at the Ear Shenmen) or sham acupuncture (minimal acupunc...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Chan YY, Lo WY, Li TC, Shen LJ, Yang SN, Chen YH, Lin JG Tags: Am J Chin Med Source Type: research

The Indispensable Value of Clinical Trials in the Modernization of Traditional Chinese Medicine: 12 Years' Experience at CUHK and Future Perspectives.
Abstract The last decade has seen a wealth of information reporting the beneficial effects of Chinese herbal medicines. While a lot more studies were done using in vitro and in vivo research platforms, much fewer investigations were conducted according to evidence-based requirements in clinical settings. The Institute of Chinese Medicine at the Chinese University of Hong Kong (CUHK) has had the opportunity to collaborate with clinicians over the years to initiate and conduct dozens of clinical trials investigating and verifying the therapeutic values of Chinese herbs in selected disease conditions. Of the many dis...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Liang W, Yew DT, Hon KL, Wong CK, Kwok TC, Leung PC Tags: Am J Chin Med Source Type: research

Blood Pressure Lowering Effect of Korea Ginseng Derived Ginseol K-g1.
Abstract We investigated the effect of Panax ginseng extract, which is rich in the ginsenoside protopanaxatriol (Ginseol K-g1), on blood pressure (BP). Adults over 20 years old with a systolic BP (SBP) between 120 and 159 mm Hg or a diastolic BP (DBP) between 80 and 99 mm Hg were included. At the end of an initial 2-week washout period, the patients were divided into three groups: the control group (placebo), the low-dose Ginseol K-g1 group (100 mg), and the high-dose Ginseol K-g1 (300 mg) group. The primary end point was the difference in seated SBP (seSBP) and seated DBP (seDBP) changes between the placebo and G...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Rhee MY, Cho B, Kim KI, Kim J, Kim MK, Lee EK, Kim HJ, Kim CH Tags: Am J Chin Med Source Type: research

Magnolol Reduced TNF-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells via JNK/p38 and NF-κB Signaling Pathways.
Magnolol Reduced TNF-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells via JNK/p38 and NF-κB Signaling Pathways. Am J Chin Med. 2014;42(3):619-37 Authors: Liang CJ, Lee CW, Sung HC, Chen YH, Wang SH, Wu PJ, Chiang YC, Tsai JS, Wu CC, Li CY, Chen YL Abstract Expression of cell adhesion molecules by the endothelium and the attachment of leukocytes to these cells play major roles in inflammation and cardiovascular disorders. Magnolol, a major active component of Magnolia officinalis, has antioxidative and anti-inflammatory properties. In the present study, the effect...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Liang CJ, Lee CW, Sung HC, Chen YH, Wang SH, Wu PJ, Chiang YC, Tsai JS, Wu CC, Li CY, Chen YL Tags: Am J Chin Med Source Type: research

Ixeris dentata Decreases ER Stress and Hepatic Lipid Accumulation through Regulation of ApoB Secretion.
This study was designed to identify ER stress regulators with potential effects against hepatic lipid accumulation. Ixeris dentata (IXD) is a traditional herbal remedy for indigestion, hepatitis, and diabetes used in Korea, Japan, and China. To examine the regulatory effects of IXD against hepatic lipid accumulation and elucidate its suggested mechanism of ER stress, HepG2 hepatocytes were treated with IXD extract in the presence of palmitate. While palmitate induced an ER stress response in hepatocytes, as indicated by the upregulation of PERK, increased eukaryotic initiation factor 2α (eIF2α) phosphorylation,...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Lee MR, Lee HY, Lee GH, Kim HK, Kim NY, Kim SH, Kim HR, Chae HJ Tags: Am J Chin Med Source Type: research

Houttuynia cordata Attenuates Lipid Accumulation via Activation of AMP-Activated Protein Kinase Signaling Pathway in HepG2 Cells.
Abstract Houttuynia cordata (H. cordata) from the family Saururaceae is a perennial herb native to Southeast Asia. It possesses a range of medicinal properties to treat several disease symptoms including allergic inflammation and anaphylaxis. In the present investigation, we provided the molecular mechanisms underlying the role of H. cordata extract (HCE) in the prevention of high glucose-induced lipid accumulation in human HepG2 hepatocytes. HepG2 cells were pre-treated with various concentrations of HCE (0, 10, 20, 40, and 80 μg/mL) and treated with serum-free medium with normal glucose (5 mM) for 1 h, follow...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Kang H, Koppula S Tags: Am J Chin Med Source Type: research

Effects of Psoraleae fructus and Its Major Component Psoralen on Th2 Response in Allergic Asthma.
This study is aimed to evaluate the effects of Psoraleae fructus (PF) on Th2 responses in a rat model of asthma in vivo and psoralen, a major constituent in PF, on Th2 responses in vitro. A rat model of asthma was established by sensitization and challenged with ovalbumin (OVA). Airway hyperresponsiveness was detected by direct airway resistance analysis. Lung tissues were examined for cell infiltration and mucus hypersecretion. Bronchoalveolar lavage fluid (BALF) was assessed for cytokine levels. In vitro study, Th2 cytokine production was evaluated in the culture supernatant of D10.G4.1 (D10 cells) followed by the determ...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Jin H, Wang L, Xu C, Li B, Luo Q, Wu J, Lv Y, Wang G, Dong J Tags: Am J Chin Med Source Type: research

Effects of Cichoric Acid Extract from Echinacea purpurea on Collagen-Induced Arthritis in Rats.
Abstract Cichoric acid extract (CAE) from Echinacea purpurea L. was used to investigate the anti-arthritic effect by using collagen-induced arthritis (CIA) rat model. The hind paw swelling volume and the body weight were measured and recorded. All the drug solutions were administered orally to rats for a total of 28 days. On day 28, the rats were anaesthetized and decapitated. The thymus and spleen were weighed for the determination of the organ index. The concentration of tumor necrosis factor alpha (TNFα), interleukin-1 beta (IL-1β) and prostaglandin E2 (PGE-2) in the serum was measured using commerci...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Jiang L, Li W, Wang Y, Zhang X, Yu D, Yin Y, Xie Z, Yuan Y Tags: Am J Chin Med Source Type: research

S-allyl L-cysteine protects the retina against kainate excitotoxicity in the rat.
Abstract Excitotoxicity has been proposed to play a pivotal role in retinal ischemia. Retinal ischemia-associated ocular disorders are vision threatening. The aim was to also examine whether and how S-allyl L-cysteine (SAC) can protect the retina against kainate excitotoxicity. In vivo retinal excitotoxicity was induced by an intravitreous injection of 100 μM kainate into a Wistar rat eye for 1 day. The management and mechanisms involved in the processes were evaluated by electrophysiology, immunohistochemistry, histopathology, and various biochemical approaches. In the present study, the cultured retinal cells...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Chao HM, Chen IL, Liu JH Tags: Am J Chin Med Source Type: research

The Effects of Baicalin Against UVA-Induced Photoaging in Skin Fibroblasts.
Abstract Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown to have anti-oxidant and anti-inflammatory properties that may delay the photoaging process. In the current study, cultured human skin fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior to 10 J/cm(2) UVA irradiation. In order to examine the efficacy of baicalin treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes, anti-oxidant activity, telomere length, and DNA damage markers. UVA radiation caus...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Min W, Liu X, Qian Q, Lin B, Wu D, Wang M, Ahmad I, Yusuf N, Luo D Tags: Am J Chin Med Source Type: research

Bufalin Induces Cell Death in Human Lung Cancer Cells through Disruption of DNA Damage Response Pathways.
In conclusion, bufalin induced DNA damage in NCI-H460 cells and also inhibited its DNA repair and checkpoint function. PMID: 24871662 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Wu SH, Wu TY, Hsiao YT, Lin JH, Hsu SC, Hsia TC, Yang ST, Hsu WH, Chung JG Tags: Am J Chin Med Source Type: research

Novel Target Genes Responsive to Apoptotic Activity by Ocimum gratissimum in Human Osteosarcoma Cells.
Abstract Osteosarcoma (OS) is a type of bone cancer. Eighty percent of this tumor will metastasize to the lungs or liver, and as a result, patients generally need chemotherapy to improve survival possibility. Recently, antitumor activity has been reported in Ocimum gratissimum aqueous extract (OGE), which has been the focus of recent extensive studies on therapeutic strategies due to its antioxidant properties. We performed pharmacogenomics analyses for the effect of OGE on human osteosarcoma U2-OS and HOS cell growth. Cell viability, Western blot and flow cytometry analysis were performed before performing pharma...
Source: The American Journal of Chinese Medicine - June 2, 2014 Category: Complementary Medicine Authors: Lin CC, Chao PY, Shen CY, Shu JJ, Yen SK, Huang CY, Liu JY Tags: Am J Chin Med Source Type: research

Eight-year survival of AIDS patients treated with chinese herbal medicine.
Abstract Treatment of acquired immunodeficiency syndrome (AIDS) currently relies on the use of antiretroviral drugs. Little is known about Chinese herbal medicine (CHM) outcomes in patients living with AIDS. We conducted a cohort study to investigate long-term survival among CHM-treated AIDS patients. Patients were poor farmers who contracted HIV-1 infection when selling blood in the 1990s. Symptoms of AIDS included recurring respiratory tract infections with a clinical diagnosis of pneumonia, swollen lymph nodes and weight loss. 385 patients with AIDS were included and 165 of them used a 16-herb formula for 14 da...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Zhao HL, Sun CZ, Jiang WP, Dai ZK, Shi WX, Yang KK, Mu XJ, Zhang XX, Sui Y Tags: Am J Chin Med Source Type: research

Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review.
Abstract Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural products, such as antineoplastic drugs, AE has attracted much attention due to its remarkable antineoplastic activity on multiple tumor cells involving multi-channel mechanisms, including the disruption of cell cycle, induction of apoptosis, anti-metastasis, antiangiogenic, and strengthening of immune function. Experimental data have revealed AE as a potentially potent anti-cancer candidate. Despit...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Chen R, Zhang J, Hu Y, Wang S, Chen M, Wang Y Tags: Am J Chin Med Source Type: research

Wrist-ankle acupuncture for pain after transcatheter arterial chemoembolization in patients with liver cancer: a randomized controlled trial.
This study was designed to evaluate the analgesic effect of wrist-ankle acupuncture (WAA) for patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE). Sixty PLC patients with post-TACE visual analog pain intensity scores greater than 3 were divided equally into two groups receiving either WAA or oral morphine sulphate (MOR) for post-TACE pain. Pain intensity scores were reassessed at 1, 2, 4, and 6 h after analgesic intervention. Patients were also monitored for adverse reactions to analgesic treatment. Pain scores recorded when the patients first felt pain after TACE showed no statis...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Zeng K, Dong HJ, Chen HY, Chen Z, Li B, Zhou QH Tags: Am J Chin Med Source Type: research

Clinical effectiveness of acupuncture for carpal tunnel syndrome.
Abstract Acupuncture and electroacupuncture treatments of symptomatic carpal tunnel syndrome (CTS) may improve symptoms and aid nerve repair as well as improve sensory and motor functions. However, limited evidence is available regarding the effects of these treatments based on comprehensive evaluation methods. This research completed the treatment and evaluation of 26 patients with confirmed CTS. Participants were divided into two treatment groups based on a modified neurophysiological grading scale. Of the total number of participants, 15 received acupuncture and 11 received electroacupuncture on both upper limb...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Ho CY, Lin HC, Lee YC, Chou LW, Kuo TW, Chang HW, Chen YS, Lo SF Tags: Am J Chin Med Source Type: research

Consumption of Mesona chinensis Attenuates Postprandial Glucose and Improves Antioxidant Status Induced by a High Carbohydrate Meal in Overweight Subjects.
The objective of this study was to investigate in vitro antioxidant and intestinal α-glucosidase inhibitory activities of Mesona chinensis (MC). In addition, the acute effect of MC on postprandial glucose and plasma antioxidant status after the consumption of a high carbohydrate (HC) meal by overweight subjects was also determined. The results showed that total phenolic and flavonoid contents in the extract were 212.37 ± 5.64 mg gallic acid equivalents/g dried extract and 23.44 ± 2.50 mg catechin equivalents/g dried extract, respectively. MC extract markedly inhibited the intestinal maltase and sucrose ...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Chusak C, Thilavech T, Adisakwattana S Tags: Am J Chin Med Source Type: research

Puerarin attenuates calcification of vascular smooth muscle cells.
Abstract Several studies demonstrate that estradiol can prevent arterial calcification. However, little is known regarding the effect of puerarin, a phytoestrogen extracted from Radix Puerariae, on arterial calcification. The aim of the present study was to determine whether puerarin reduced osteoblastic differentiation of calcifying vascular smooth muscle cells (CVSMCs). The CVSMCs were isolated from mice aorta and treated with different concentrations of puerarin. The alkaline phosphatase (ALP) activity, osteocalcin secretion and Runx2 expression were determined. To examine whether estrogen receptors (ERs) PI3K ...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Lu Q, Xiang DX, Yuan HY, Xiao Y, Yuan LQ, Li HB Tags: Am J Chin Med Source Type: research

Intestinal Absorptive Transport of Genkwanin from Flos genkwa Using a Single-Pass Intestinal Perfusion Rat Model.
Abstract To investigate the absorptive transport behavior of genkwanin and the beneficial effects of monoterpene enhancers with different functional groups, the single-pass intestinal perfusion (SPIP) of rats was used. The results showed that genkwanin was segmentally-dependent and the best absorptive site was the duodenum. The effective permeability coefficient (P eff ) was 1.97 × 10(-4) cm/s and the absorption rate constant (Ka) was 0.62 × 10(-2) s(-1). Transepithelial transportation descended with increasing concentrations of genkwanin. This was a 1.4-fold increase in P eff by probenecid, whereas a ...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Jiang CP, He X, Yang XL, Zhang SL, Li H, Song ZJ, Zhang CF, Yang ZL, Li P Tags: Am J Chin Med Source Type: research

Effect of paeonol on tissue destruction in experimental periodontitis of rats.
Abstract We evaluated the effects of paeonol, a phenolic compound of Moutan Cortex, on the tissue inflammation and destruction in experimental periodontitis of rats. The maxillary palatal bony surfaces of 18 rats received injections of lipopolysaccharide (LPS, 5 mg/mL), PBS or LPS-plus-paeonol (40 mg/kg, intra-peritoneal injection) for three days. Five days later, the osteoclasts were examined and compared after tartrate-resistant acid phosphatase staining. In another 36 rats, the experimental periodontitis was induced by placing the ligatures around the maxillary second and mandibular first molars. Seven days lat...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Chang CY, Fu E, Chiang CY, Chang WJ, Cheng WC, Tu HP Tags: Am J Chin Med Source Type: research

Effect of Ajuga bracteosa on Systemic T-Cell Immunity in Balb/C Mice: Dual Th1/Th2 Immunostimulatory Effects.
Abstract Ajuga bracteosa (AB) has been widely used in folk medicine in Asian countries against gout, hepatitis, pneumonia, rheumatism, and various neuro inflammatory disorders. The aim of this study was to investigate the possible immunoregulatory effects of the ethanolic extract of Ajuga bracteosa (ABEE) on systemic Th1/Th2 immunity in SRBC immunized Balb/C mice. Animals were orally administered with graded doses of ABEE from 6.25 mg/kg to 100 mg/kg. Post sub-cutaneous immunization with SRBCs and circulating antibody titers, DTH responses and splenocyte proliferation was monitored as markers of Th2 and Th1 respon...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Nisar A, Akhtar N, Hassan A, Banday T, Wani B, Zargar MA Tags: Am J Chin Med Source Type: research

Study on Integrated Pharmacokinetics of Gardenia Acid and Geniposide: Time-Antioxidant Efficacy after Oral Administration of Huanglian-Zhizi Couplet Medicine from Huang-Lian-Jie-Du-Tang in MCAO Rats.
Abstract Huanglian-Zhizi couplet medicine comes from classical prescription Huang-Lian-Jie-Du-Tang (HLJDT), which has been proven by previous researches to be an effective compound for cerebral ischemia. This paper explores the integrated pharmacokinetics of gardenia acid and geniposide-time-antioxidant efficacy after the oral administration of Huanglian-Zhizi couplet medicine from HLJDT in rats with middle cerebral artery occlusion (MCAO). To investigate the differences in pharmacokinetics and antioxidant effect of Huanglian-Zhizi and HLJDT in MCAO rats, which have been scarcely reported, an oral dose, 24 crud dr...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Pan L, Zhou J, Zhu H, Wang W, Zhang M, Tian X, Lu J, Zeng M Tags: Am J Chin Med Source Type: research

Er-xian decoction exerts estrogen-like osteoprotective effects in vivo and in vitro.
Abstract Er-xian Decoction (EXD), containing Herba epimedii Maxim (HEP) and Curculigo orchioides Gaertn (XM) as principal drugs, is a traditional Chinese medicine (TCM) formula prescribed for the treatment of postmenopausal osteoporosis. In the present study, the in vivo anti-osteoporosis effects of EXD, HEP and XM on four-month-old ovariectomized (OVX) Sprague-Dawley rats were investigated. Micro-computed tomography analysis showed that EXD could significantly improve the micro-architectural parameters (BMD, BV/TV, Tb.N, Tb.Th, and Tb.Sp) of trabecular bone in the distal femur and proximal tibia in OVX rats (p
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Wong KC, Lee KS, Luk HK, Wan HY, Ho CK, Zhang Y, Wong MS Tags: Am J Chin Med Source Type: research

Cordyceps sinensis Prevents Apoptosis in Mouse Liver with D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure.
Abstract Cordyceps sinensis (C. sinensis) has long been considered to be an herbal medicine and has been used in the treatment of various inflammatory diseases. The present study examined the cytoprotective properties of C. sinensis on D(+)-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were randomly assigned into control, GalN/LPS, CS 20 mg and CS 40 mg groups (C. sinensis, oral gavage, five days/week, four weeks). After receiving saline or C. sinensis, mice were intraperitoneally given GalN (800 mg/kg)/LPS (10 μg/kg). The effects of C. sinensis on TNF-α, IL-10, AST...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Cheng YJ, Cheng SM, Teng YH, Shyu WC, Chen HL, Lee SD Tags: Am J Chin Med Source Type: research

Citrus medica var. sarcodactylis (Foshou) Activates Fibroblast Growth Factor-2 Signaling to Induce Migration of RSC96 Schwann Cells.
Abstract Factors that enhance the intrinsic growth potential of neurons play a major role in the regeneration and repair of adult neurons following an injury. Fibroblast growth factor (FGF-2) is one of the key players in the origin and growth of neuronal and glial cells through autocrine and paracrine signaling. Water extract of Citrus medica var. sarcodactylis (fingered citron, foshou), which is been used effectively as a Chinese herbal medicine, was found to activate the FGF-2 promoter in transgenic luciferase expression models. Foshou treatment on Schwann cells (RSC96) transfected with luciferase reporter plasm...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Huang CY, Kuo WW, Shibu MA, Hsueh MF, Chen YS, Tsai FJ, Yao CH, Lin CC, Pan LF, Ju DT Tags: Am J Chin Med Source Type: research

Regulatory Effects of Siegesbeckia glabrescens on Non-Small Cell Lung Cancer Cell Proliferation and Invasion.
Abstract Siegesbeckia glabrescens (SG) Makino (Compositae) has been used as a traditional medicine for the treatment of allergic and inflammatory diseases. In the present study, we examined the effects and molecular mechanism of the ethanol extract of SG on cell proliferation and invasion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. SG treatment markedly inhibited the proliferation and invasion in both cell lines, independently of p53 expression. The anti-proliferative effect of SG on A549 cells was mediated by the inactivation of Akt and p70(S6K) as evidenced by treatmen...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Lee HN, Joo JH, Oh JS, Choi SW, Seo DW Tags: Am J Chin Med Source Type: research

Flavonoids Identified from Korean Scutellaria baicalensis Induce Apoptosis by ROS Generation and Caspase Activation on Human Fibrosarcoma Cells.
Abstract The effects of flavonoids from Korean Scutellaria baicalensis on fibrosarcoma HT1080 cells and their underlying molecular mechanism were investigated in this study. Flavonoids affected HT1080 cell proliferation by interrupting cell cycle progress, obviously augmenting the proportion of sub-G1 and diminishing that of G1 phase, and undergoing apoptosis at the tested dosage (100-400 μg/mL). In addition, the mediated apoptosis was mainly caused by total reactive oxygen species (ROS) generation and by up-regulating the ratio of Bax/Bcl-xL, triggering caspase cascades (caspase-3, -9 and -8), and inactivating...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Zhang J, Park HS, Kim JA, Hong GE, Nagappan A, Park KI, Kim GS Tags: Am J Chin Med Source Type: research

Triptolide Synergistically Enhances Temozolomide-Induced Apoptosis and Potentiates Inhibition of NF-κB Signaling in Glioma Initiating Cells.
In this study, we explored the interaction of TPL and TMZ in glioma-initiating cells (GICs) and the potential mechanism. A GIC line (GIC-1) was successfully established. Cell viability of GIC-1 after treatment was measured using a CCK-8 assay. The interaction between TPL and TMZ was calculated from Chou-Talalay equations and isobologram. Self-renewal was evaluated with tumor sphere formation assay. Apoptosis was assessed with flow cytometry and western blot. Luciferase assay was employed to measure NF-κB transcriptional activity. The expression of NF-κB downstream genes, NF-κB nuclear translocalization an...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Sai K, Li WY, Chen YS, Wang J, Guan S, Yang QY, Guo CC, Mou YG, Li WP, Chen ZP Tags: Am J Chin Med Source Type: research

Medicinal herbs in the prevention and treatment of osteoporosis.
Abstract Osteoporosis is a common disease with wide prevalence, especially in the elderly population. Osteoporosis induced fractures not only decrease the patient's life quality, but also cause heavy financial burden to the society. Although current medications for osteoporosis are effective, numerous adverse effects have been observed accompanying their clinical applications. Effective prevention and therapy strategies with high safety are critical, which benefit both individual patients and the whole society. Traditional Chinese medicines have been used for thousands of years to treat bone related diseases in Ch...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Li C, Li Q, Liu R, Niu Y, Pan Y, Zhai Y, Mei Q Tags: Am J Chin Med Source Type: research

Phytochemistry and Biology of Loranthus parasiticus Merr, a Commonly Used Herbal Medicine.
Abstract Loranthus parasiticus Merr (L. parasiticus) is a member of Loranthaceae family and is an important medicinal plant with a long history of Chinese traditional use. L. parasiticus, also known as Sang Ji Sheng (in Chinese), benalu teh (in Malay) and baso-kisei (in Japanese), is a semiparasitic plant, which is mostly distributed in the southern and southwestern regions of China. This review aims to provide a comprehensive overview of the ethnomedicinal use, phytochemistry and pharmacological activity of L. parasiticus and to highlight the needs for further investigation and greater global development of the p...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Moghadamtousi SZ, Kamarudin MN, Chan CK, Goh BH, Kadir HA Tags: Am J Chin Med Source Type: research

Traditional chinese medicine injection for angina pectoris: an overview of systematic reviews.
Abstract Traditional Chinese medicine (TCM) injection is widely used to treat angina pectoris in China. This overview aims to systematically summarize the general characteristics of systematic reviews (SRs) on TCM injection in treating angina, and assess the methodological and reporting quality of these reviews. We searched PubMed, Embase, the Cochrane Library and four Chinese databases from inception until March 2013. Data were extracted according to a preset form. The AMSTAR and PRISMA checklists were used to explore the methodological quality and reporting characteristics of included reviews, respectively. All ...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Luo J, Shang Q, Han M, Chen K, Xu H Tags: Am J Chin Med Source Type: research

Therapeutic Angiogenesis after Ischemic Stroke: Chinese Medicines, Bone Marrow Stromal Cells (BMSCs) and their Combinational Treatment.
Abstract Ischemic stroke is a clinical acute disease which causes neurological dysfunction and threatens a patient's life. Because the mechanism of pathology is complicated and most patients miss the best therapeutic window time, the effect of the treatment is not satisfied at present. Numerous studies indicated new vessels not only recuperated blood flow in the ischemic boundary zone, but also facilitated endogenous neurogenesis and improved neurological function after ischemic stroke. Therefore, angiogenesis has been an important research field in neurovascular regeneration. Recently, some Chinese medicines, bon...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Zhang Q, Zhao YH Tags: Am J Chin Med Source Type: research

Baicalein Protects Cardiomyocytes Against Mitochondrial Oxidant Injury Associated with JNK Inhibition and Mitochondrial Akt Activation.
Abstract Baicalein, a flavonoid derived from Scutellaria baicalensis Georgi, possesses cardioprotection against oxidant injury by scavenging reactive oxygen species (ROS). Few studies investigate whether baicalein protection is mediated by attenuating mitochondrial ROS and modulating the prosurvival and proapoptotic signaling. Primary cultured chick cardiomyocytes were used to study the role of baicalein in mitochondrial superoxide [Formula: see text] generation and signaling of Akt and JNK. Cells were exposed to H 2 O 2 for 2 h and baicalein was given 2 h prior to and during 2 h of H 2 O 2 exposure. Cell viabilit...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Huang HH, Shao ZH, Li CQ, Vanden Hoek TL, Li J Tags: Am J Chin Med Source Type: research

Semen cassiae attenuates myocardial ischemia and reperfusion injury in high-fat diet streptozotocin-induced type 2 diabetic rats.
This study investigated whether the Semen Cassiae extract (SCE) reduces myocardial ischemia and reperfusion (MI/R) injury with or without diabetes and the underlying mechanisms. The high-fat diet-fed streptozotocin (HFD-STZ) rat model was created as a T2DM model. Normal and DM rats received SCE treatment orally (10 mg/kg/day) for one week. Subsequently these animals were subjected to MI/R. Compared with the normal animals, DM rats showed increased plasma total cholesterol (TC) and triacylglycerol (TG), and more severe MI/R injury and cardiac functional impairment. SCE treatment significantly reduced the plasma TC and TG, i...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Fu F, Tian F, Zhou H, Lv W, Tie R, Ji L, Li R, Shi Z, Yu L, Liang X, Xing W, Xing J, Yu J, Sun L, Zhu H, Zhang H Tags: Am J Chin Med Source Type: research

Clinical efficacy of aconitum-containing traditional chinese medicine for diabetic peripheral neuropathic pain.
We report a more effective treatment of diabetic peripheral neuropathic pain using a high dose of a traditional Chinese medicine, aconitum (including both Radix aconite preparata and Radix aconite kusnezoffii), in combination with Huangqi Guizhi Wuwu Tang (i.e., astragalus, cassia twig, white peony root, and spatholobi). In order to achieve stronger analgesic effects, we increased the clinical dosage of aconitum from 15 to 120 g. The aconitum was boiled for 6-8 hours, and licorice was also used to reduce potential toxicities of aconitum. In the four reported cases, the patients' neuropathic pain was remarkably reduced and ...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Feng L, Liu WK, Deng L, Tian JX, Tong XL Tags: Am J Chin Med Source Type: research

Phosphatase-Mediated Intracellular Signaling Contributes to Neuroprotection by Flavonoids of Iris tenuifolia.
Abstract A variety of flavonoids are suggested to be useful for the treatment of brain-related disorders, including dementia and depression. An investigation on the characteristics of the extracted compounds of Iris tenuifolia Pall. (IT) is of much interest, as this plant has been used as a traditional medicine. In the present study, we examined the effect of total flavonoids obtained from IT on cultured cortical neurons under oxidative-stress and found that pretreatment with IT flavonoids significantly inhibited H 2 O 2-induced cell death in cortical neurons. Such a survival-promoting effect by IT flavonoids was ...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Jalsrai A, Numakawa T, Ooshima Y, Adachi N, Kunugi H Tags: Am J Chin Med Source Type: research

Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice.
Abstract Cyclophosphamide is one of the most widely used chemotherapeutic agents in treating cancers. Chemotherapy drug-induced oxidative stress produces side effects. The severity of myelosuppression increases with a high dose of cyclophosphamide. Chicken soup or chicken essence, a traditional Chinese aliment, is a popular health supplement for patients with cancers or other diseases in Asia. As a major functional component of chicken meat extract, carnosine (beta-alanyl-L-histidine), a dipeptide of the amino acids beta-alanine and histidine, has been shown to have strong antioxidant activities. In the present st...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Xu M, He RR, Zhai YJ, Abe K, Kurihara H Tags: Am J Chin Med Source Type: research

Du-Zhong (Eucommia ulmoides) Prevents Disuse-Induced Osteoporosis in Hind Limb Suspension Rats.
The objective of the present study is to systematically investigate the effects of Du-Zhong cortex extract (DZCE) on disuse-induced osteoporosis. Rats were randomly divided into four groups, and three groups were treated with hind limb suspension (HLS). Control and HLS group received deionized distilled water, while the other two groups received alendronate (2.0 mg/kg/day) and DZCE (300 mg/kg/day) respectively by intragastric gavage for six weeks (two weeks prior to and during the four weeks of HLS). Dual-energy X-ray absorptiometry, assay of biochemical markers, and three-point bending test were employed to determine the ...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Pan Y, Niu Y, Li C, Zhai Y, Zhang R, Guo X, Mei Q Tags: Am J Chin Med Source Type: research

Withania somnifera Attenuates Acid Production, Acid Tolerance and Extra-Cellular Polysaccharide Formation of Streptococcus mutans Biofilms.
Abstract Withania somnifera (Ashwagandha) is a plant of the Solanaceae family. It has been widely used as a remedy for a variety of ailments in India and Nepal. The plant has also been used as a controlling agent for dental diseases. The aim of the present study was to evaluate the activity of the methanol extract of W. somnifera against the physiological ability of cariogenic biofilms and to identify the components of the extract. To determine the activity of the extract, assays for sucrose-dependent bacterial adherence, glycolytic acid production, acid tolerance, and extracellular polysaccharide formation were p...
Source: The American Journal of Chinese Medicine - January 29, 2014 Category: Complementary Medicine Authors: Pandit S, Song KY, Jeon JG Tags: Am J Chin Med Source Type: research