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Triterpenoid Compounds from Cyclocarya paliurus : A Review of Their Phytochemistry, Quality Control, Pharmacology, and Structure-Activity Relationship
Am J Chin Med. 2023 Nov 10:1-35. doi: 10.1142/S0192415X2350088X. Online ahead of print.ABSTRACTCyclocarya paliurus (Batalin) Iljinskaja (C. paliurus) is a single species of Cyclocarya paliurus in Juglandaceae. It is a unique rare medicinal plant resource in China that is mainly distributed in the south of China. The leaves of C. paliurus, as a new food ingredient, are processed into tea products in daily life. Triterpenoids are the main active ingredient in C. paliurus. So far, 164 triterpenoid compounds have been isolated and identified from C. paliurus, which are included 3,4-seco-dammaranes, dammaranes, oleanane, ursane...
Source: The American Journal of Chinese Medicine - November 13, 2023 Category: Complementary Medicine Authors: Shuran Zhang Junyu He Jie Li Haibo He Yumin He Xiao Wang Heng Shu Jihong Zhang Daoxiang Xu Kun Zou Source Type: research

 Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study
Am J Chin Med. 2023 Nov 4:1-26. doi: 10.1142/S0192415X23500945. Online ahead of print.ABSTRACTCoptis chinensis Franch (RC), has historically been used for the treatment of "Xiao Ke" and "Xia Li" symptoms in China. "Xia Li" is characterized by abdominal pain and diarrhea, which are similar to the clinical symptoms of ulcerative colitis (UC). For the first time, this study aims to compare the anti-colitis effects of berberine (BBR) and total RC alkaloids (TRCA) and investigate the underlying metabolites and gut microbiota biomarkers. Metabolomics results showed that several colitis-related biomarkers, including lysophosphati...
Source: The American Journal of Chinese Medicine - November 6, 2023 Category: Complementary Medicine Authors: Rui Zhou Yangyi Huang Congjian Tian Yong Yang Zaiqi Zhang Kai He Source Type: research

Andrographolide Attenuates Oxidized LDL-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages and Mitigates HFCCD-Induced Atherosclerosis in Mice
Am J Chin Med. 2023 Nov 4:1-19. doi: 10.1142/S0192415X23500933. Online ahead of print.ABSTRACTAndrographolide (AND) is a bioactive component of the herb Andrographis paniculata and a well-known anti-inflammatory agent. Atherosclerosis is a chronic inflammatory disease of the vasculature, and oxidized LDL (oxLDL) is thought to contribute heavily to atherosclerosis-associated inflammation. The aim of this study was to investigate whether AND mitigates oxLDL-mediated foam cell formation and diet-induced atherosclerosis (in mice fed a high-fat, high-cholesterol, high-cholic acid [HFCCD] diet) and the underlying mechanisms invo...
Source: The American Journal of Chinese Medicine - November 6, 2023 Category: Complementary Medicine Authors: Chih-Chieh Chen Chong-Kuei Lii Kai-Li Liu Yi-Ling Lin Chia-Wen Lo Chien-Chun Li Ya-Chen Yang Haw-Wen Chen Source Type: research

Isoliquiritigenin Inhibits Oral Squamous Cell Carcinoma and Overcomes Chemoresistance by Destruction of Survivin
Am J Chin Med. 2023 Nov 4:1-21. doi: 10.1142/S0192415X23500957. Online ahead of print.ABSTRACTThe oncoprotein survivin plays a pivotal role in controlling cell division and preventing apoptosis by inhibiting caspase activation. Its significant contribution to tumorigenesis and therapeutic resistance has been well established. Isoliquiritigenin (ISL), a natural compound, has been recognized for its powerful inhibitory effects against various tumors. However, whether ISL exerts regulatory effects on survivin and its underlying mechanism in oral squamous cell carcinoma (OSCC) remains unclear. Here, we found that ISL inhibited...
Source: The American Journal of Chinese Medicine - November 6, 2023 Category: Complementary Medicine Authors: Zhongsu Zhou Shuangze Han Jinzhuang Liao Ruirui Wang Xinfang Yu Ming Li Source Type: research

Coptisine, the Characteristic Constituent from Coptis chinensis , Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases
Am J Chin Med. 2023 Nov 4:1-36. doi: 10.1142/S0192415X2350091X. Online ahead of print.ABSTRACTNaturally derived alkaloids belong to a class of quite significant organic compounds. Coptisine, a benzyl tetrahydroisoquinoline alkaloid, is one of the major bioactive constituents in Coptis chinensis Franch., which is a famous traditional Chinese medicine. C. chinensis possesses many kinds of functions, including the ability to eliminate heat, expel dampness, purge fire, and remove noxious substances. In Asian countries, C. chinensis is traditionally employed to treat carbuncle and furuncle, diabetes, jaundice, stomach and intes...
Source: The American Journal of Chinese Medicine - November 6, 2023 Category: Complementary Medicine Authors: Qiang Lu Ying Tang Shuang Luo Qihai Gong Cailan Li Source Type: research

Chinese Materia Medica in Treating Depression: The Role of Intestinal Microenvironment
Am J Chin Med. 2023 Nov 4:1-29. doi: 10.1142/S0192415X23500854. Online ahead of print.ABSTRACTDepression is a highly heterogeneous mental illness. Drug treatment is currently the main therapeutic strategy used in the clinic, but its efficacy is limited by the modulation of a single target, slow onset, and side effects. The gut-brain axis is of increasing interest because intestinal microenvironment disorders increase susceptibility to depression. In turn, depression affects intestinal microenvironment homeostasis by altering intestinal tissue structure, flora abundance and metabolism, hormone secretion, neurotransmitter tr...
Source: The American Journal of Chinese Medicine - November 6, 2023 Category: Complementary Medicine Authors: Ruhui Shen Zhipeng Li Huiyun Wang Yongchao Wang Xiaofang Li Qian Yang Yingjie Fu Ming Li Li-Na Gao Source Type: research