Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by < sup > 1 < /sup > H-NMR metabolomics profiling
In this study, 1H NMR based metabolomics approach, complemented with histopathological observation, biochemical measurements, western blotting analysis and real-time quantitative PCR (RT-qPCR), was applied to interpret the paradox of emodin (30 mg/kg, 10 mg/kg BW) using both healthy mice (male, ICR) and chronic CCl4-injured mice (0.1 mL/kg, 0.35% CCl4, 3 times a week for a month). Emodin exerted a weight loss property associated with its lipid-lowing effects, which helped alleviate CCl4-induced steatosis. Emodin effectively ameliorated CCl4-induced oxidative stress and energy metabolism dysfunction in mice liver via regula...
Source: Toxicology and Applied Pharmacology - October 4, 2021 Category: Toxicology Authors: Lingyu Ruan Lei Jiang Wenlong Zhao Huihui Meng Qi Zheng Junsong Wang Source Type: research
Hepatotoxicity or hepatoprotection of emodin? Two sides of the same coin by < sup > 1 < /sup > H-NMR metabolomics profiling
In this study, 1H NMR based metabolomics approach, complemented with histopathological observation, biochemical measurements, western blotting analysis and real-time quantitative PCR (RT-qPCR), was applied to interpret the paradox of emodin (30 mg/kg, 10 mg/kg BW) using both healthy mice (male, ICR) and chronic CCl4-injured mice (0.1 mL/kg, 0.35% CCl4, 3 times a week for a month). Emodin exerted a weight loss property associated with its lipid-lowing effects, which helped alleviate CCl4-induced steatosis. Emodin effectively ameliorated CCl4-induced oxidative stress and energy metabolism dysfunction in mice liver via regula...
Source: Toxicology and Applied Pharmacology - October 4, 2021 Category: Toxicology Authors: Lingyu Ruan Lei Jiang Wenlong Zhao Huihui Meng Qi Zheng Junsong Wang Source Type: research
Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics
Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most severe side effects of herbal medicine which is an increasing concern around the world. Reynoutria multiflora (Thunb.) Moldenke (Polygonum multiflorum Thunb., PM) is the most common herb that can cause herb-induced liver injury (HILI). The recent scientific and technological advancements in clinical and basic research are paving the way for a better understanding of the molecular aspects of PM-related HILI (PM-HILI). This review provides an updated overview of the clinical characteristics, predisposing factors, hepatotoxic compone...
Source: Frontiers in Pharmacology - September 2, 2021 Category: Drugs & Pharmacology Source Type: research
Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein
Evid Based Complement Alternat Med. 2021 Aug 17;2021:4582412. doi: 10.1155/2021/4582412. eCollection 2021.ABSTRACTRhein, belonging to anthraquinone compounds, is one of the main active components of rhubarb and Polygonum multiflorum. Rhein has a variety of pharmacological effects, such as cardiocerebral protective effect, hepatoprotective effect, nephroprotective effect, anti-inflammation effect, antitumor effect, antidiabetic effect, and others. The mechanism is interrelated and complex, referring to NF-κB, PI3K/Akt/MAPK, p53, mitochondrial-mediated signaling pathway, oxidative stress signaling pathway, and so on. Howeve...
Source: Evidence-based Complementary and Alternative Medicine - August 30, 2021 Category: Complementary Medicine Authors: Gang-Min Li Jun-Ren Chen Hui-Qiong Zhang Xiao-Yu Cao Chen Sun Fu Peng Yan-Peng Yin Ziwei Lin Lei Yu Yan Chen Yun-Li Tang Xiao-Fang Xie Cheng Peng Source Type: research
Screening of Quality Markers During the Processing of Reynoutria multiflora Based on the UHPLC-Q-Exactive Plus Orbitrap MS/MS Metabolomic Method
The root of Reynoutria multiflora (Thunb.) Moldenke (syn: Polygonum multiflorum Thunb.) is a distinguished herb that has been popularly used in traditional Chinese medicine. The raw Reynoutria multiflora (RRM) should be processed by steaming before use, and the processing time is not specified in the processing specification. Our previous studies showed that the efficacy and toxicity of processed Reynoutria multiflora (PRM) at different processing times were inconsistent. A comprehensive identification method was established in this study to find a quality marker of raw Reynoutria multiflora (RRM) and processed Reynoutria ...
Source: Frontiers in Pharmacology - August 11, 2021 Category: Drugs & Pharmacology Source Type: research
The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax
J Vasc Res. 2021 Jul 2:1-10. doi: 10.1159/000511035. Online ahead of print.ABSTRACTEndothelial dysfunction plays a central role in the patho-genesis of diabetic vascular complications. 2,3,5,4'-tetra-hydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from the roots of Polygonum multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In the present study, we investigated the protective effect of TSG on apoptosis induced by high glucose in human umbilical vein endothelial cells (HUVECs) and the possible mechanisms. Our data demonstrated that TSG significantly reversed t...
Source: Cell Research - July 4, 2021 Category: Cytology Authors: Jiankun Cui Bo Zhang Min Gao Baohai Liu Cong Dai Yumei Dong FanJi Meng Source Type: research
UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity
The raw and processed roots of Polygonum multiflorum Thunb (PM) are commonly used in clinical practice to treat diverse diseases; however, reports of hepatotoxicity induced by Polygoni Multiflori Radix (PMR) and ... (Source: Chinese Medicine)
Source: Chinese Medicine - July 3, 2021 Category: Complementary Medicine Authors: Jian-Bo Yang, Yun-Fei Song, Yue Liu, Hui-Yu Gao, Qi Wang, Ying Wang, Xian-Long Cheng, Tian-Tian Zuo, Xiao-Wen Hu, Feng Wei, Hong-Tao Jin, Shu-Ting Wang and Shuang-Cheng Ma Tags: Research Source Type: research
The Protective Effect of Tetrahydroxystilbene Glucoside on High Glucose-Induced Injury in Human Umbilical Vein Endothelial Cells through the PI3K/Akt/eNOS Pathway and Regulation of Bcl-2/Bax
Endothelial dysfunction plays a central role in the patho genesis of diabetic vascular complications. 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from the roots of Polygonum multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In the present study, we investigated the pro tective effect of TSG on apoptosis induced by high glucose in human umbilical vein endothelial cells (HUVECs) and the possible mechanisms. Our data demonstrated that TSG significantly reversed the high glucose-induced decrease in cell viability, suppressed high glucose-i...
Source: Journal of Vascular Research - July 2, 2021 Category: Research Source Type: research
Molecules, Vol. 26, Pages 3977: High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (Zhiheshouwu) by UHPLC-Q-Exactive Orbitrap-MS
In this study, an effective and rapid method was established to separate and characterize the constituents in PMRP by combining ultra-high performance liquid chromatography with hybrid quadrupole-orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap-MS). Based on the accurate mass measurements for molecular and characteristic fragment ions, a total of 103 compounds, including 24 anthraquinones, 21 stilbenes, 15 phenolic acids, 14 flavones, and 29 other compounds were identified or tentatively characterized. Forty-eight compounds were tentatively characterized from PMRP for the first time, and their fragmentation behaviors ...
Source: Molecules - June 29, 2021 Category: Chemistry Authors: Shaoyun Wang Xiaozhu Sun Shuo An Fang Sang Yunli Zhao Zhiguo Yu Tags: Article Source Type: research
Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
The clinical use of Polygonum multiflorum Thunb (PM) has been restricted or banned in many countries, due to its hepatotoxic adverse effects. Its toxicity research has become a hot topic. So far, the pharmacokinetic studies of PM, focusing on prototype compounds such as 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), emodin, and physcion, have been considered the main basis of pharmacodynamic material or of toxic effect. However, pharmacokinetic studies of its phase II metabolites have not yet been reported, mainly because the quantifications of such metabolites are difficult to do without the reference substance. ...
Source: Frontiers in Pharmacology - June 17, 2021 Category: Drugs & Pharmacology Source Type: research
Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
The idiosyncratic hepatotoxicity of Polygonum multiflorum (PM) has attracted considerable interest, but the idiosyncratically hepatotoxic components and endogenous metabolite changes resulting from idiosyncratic ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 12, 2021 Category: Complementary Medicine Authors: Yan Lin, Rong Xiao, Bo-hou Xia, Zhi-min Zhang, Chun Li, Ping Wu, Duan-fang Liao and Li-mei Lin Tags: Research article Source Type: research
Mechanism of natural drugs on nonalcoholic fatty liver disease
Mini Rev Med Chem. 2021 Apr 5. doi: 10.2174/1389557521666210405160658. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Its pathogenesis is closely related to insulin resistance, obesity, type 2 diabetes, and hyperlipidemia. Due to the complex pathogenesis, There are no specific medications for treating NAFLD. The most effective way to treat NAFLD is to lose weight through diet intervention and exercise, but a large number of in vitro and in vivo experiments have confirmed that a variety of natural drugs can interfere with NAFLD through many mecha...
Source: Mini Reviews in Medicinal Chemistry - April 6, 2021 Category: Chemistry Authors: Jiao Xie Ling Li Lei Zhao Source Type: research
Mechanism of natural drugs on nonalcoholic fatty liver disease
Mini Rev Med Chem. 2021 Apr 5. doi: 10.2174/1389557521666210405160658. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Its pathogenesis is closely related to insulin resistance, obesity, type 2 diabetes, and hyperlipidemia. Due to the complex pathogenesis, There are no specific medications for treating NAFLD. The most effective way to treat NAFLD is to lose weight through diet intervention and exercise, but a large number of in vitro and in vivo experiments have confirmed that a variety of natural drugs can interfere with NAFLD through many mecha...
Source: Mini Reviews in Medicinal Chemistry - April 6, 2021 Category: Chemistry Authors: Jiao Xie Ling Li Lei Zhao Source Type: research
Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - March 3, 2021 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
