Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O- β-D-glucoside，the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects
Curr Drug Metab. 2023 Feb 23. doi: 10.2174/1389200224666230223144826. Online ahead of print.ABSTRACTTraditional Chinese medicine Heshouwu, named Polygoni Multiflori Radix in Pharmacopoeia of the People's Republic of China (PPRC, 2020), is derived from the root tuber of Polygonum multiflorum Thunb. Heshouwu or processed Heshouwu is well known for its function in reducing lipids and nourishing the liver. However, increasing cases of Heshouwu-induced hepatotoxicity were reported in recent years. Researchers have begun to study the paradoxical effects of Heshouwu on the liver. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (...
Source: Current Drug Metabolism - February 24, 2023 Category: Drugs & Pharmacology Authors: Cheng-Yu Wang Ying-Huan Hu Zhen-Xiao Sun Source Type: research
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O- β-D-glucoside，the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects
Curr Drug Metab. 2023 Feb 23. doi: 10.2174/1389200224666230223144826. Online ahead of print.ABSTRACTTraditional Chinese medicine Heshouwu, named Polygoni Multiflori Radix in Pharmacopoeia of the People's Republic of China (PPRC, 2020), is derived from the root tuber of Polygonum multiflorum Thunb. Heshouwu or processed Heshouwu is well known for its function in reducing lipids and nourishing the liver. However, increasing cases of Heshouwu-induced hepatotoxicity were reported in recent years. Researchers have begun to study the paradoxical effects of Heshouwu on the liver. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (...
Source: Current Drug Metabolism - February 24, 2023 Category: Drugs & Pharmacology Authors: Cheng-Yu Wang Ying-Huan Hu Zhen-Xiao Sun Source Type: research
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O- β-D-glucoside，the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects
Curr Drug Metab. 2023 Feb 23. doi: 10.2174/1389200224666230223144826. Online ahead of print.ABSTRACTTraditional Chinese medicine Heshouwu, named Polygoni Multiflori Radix in Pharmacopoeia of the People's Republic of China (PPRC, 2020), is derived from the root tuber of Polygonum multiflorum Thunb. Heshouwu or processed Heshouwu is well known for its function in reducing lipids and nourishing the liver. However, increasing cases of Heshouwu-induced hepatotoxicity were reported in recent years. Researchers have begun to study the paradoxical effects of Heshouwu on the liver. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (...
Source: Current Drug Metabolism - February 24, 2023 Category: Drugs & Pharmacology Authors: Cheng-Yu Wang Ying-Huan Hu Zhen-Xiao Sun Source Type: research
Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O- β-D-glucoside，the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects
Curr Drug Metab. 2023 Feb 23. doi: 10.2174/1389200224666230223144826. Online ahead of print.ABSTRACTTraditional Chinese medicine Heshouwu, named Polygoni Multiflori Radix in Pharmacopoeia of the People's Republic of China (PPRC, 2020), is derived from the root tuber of Polygonum multiflorum Thunb. Heshouwu or processed Heshouwu is well known for its function in reducing lipids and nourishing the liver. However, increasing cases of Heshouwu-induced hepatotoxicity were reported in recent years. Researchers have begun to study the paradoxical effects of Heshouwu on the liver. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (...
Source: Current Drug Metabolism - February 24, 2023 Category: Drugs & Pharmacology Authors: Cheng-Yu Wang Ying-Huan Hu Zhen-Xiao Sun Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research
