Arginase Inhibitor 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Activates Endothelial Nitric Oxide Synthase and Improves Vascular Function
Planta MedDOI: 10.1055/s-0042-111014Endothelial arginase constrains the activity of endothelial nitric oxide synthase by reducing nitric oxide bioavailability, which contributes to vascular diseases. During screening, we identified a novel compound from the rhizome of Polygonum multiflorum (Polygonaceae), 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), which inhibited arginase activity. THSG exhibited noncompetitive inhibition of arginase II and inhibited both arginases I and II in a dose-dependent manner. THSG-dependent arginase inhibition reciprocally increased nitric oxide production and decreased reactive ox...
Source: Planta Medica - July 7, 2016 Category: Drugs & Pharmacology Authors: Yi, BongguNguyen, Minh CongWon, Moo-HoKim, Young MyeongRyoo, Sungwoo Tags: Original Papers Source Type: research
Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo
Conclusions Chronic administration of TSG promotes hippocampal memory in normal mice, suggesting that supplementary of TSG might serve as an enhancement of memory. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 9, 2016 Category: Drugs & Pharmacology Source Type: research
2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside suppresses human colorectal cancer cell metastasis through inhibiting NF-κB activation.
In this study, cell migration, invasion and adhesion abilities as well as metastasis-associated protein and NF-κB pathway signaling factor expression were analyzed after treating HT-29 cells with THSG. According to the results, the migration and invasiveness of HT-29 cells were reduced after treatment with 5 or 10 mM THSG (p<0.05). Additionally, the levels of matrix metalloproteinase-2 (MMP-2) and phosphorylated VE-cadherin in HT-29 cells were reduced and the transepithelial electrical resistance (TEER) of EA.hy926 endothelial cell monolayers was increased after incubation in THSG for 24 h (p<0.05). Cell adhesion ...
Source: International Journal of Oncology - June 8, 2016 Category: Cancer & Oncology Authors: Lin CL, Hsieh SL, Leung W, Jeng JH, Huang GC, Lee CT, Wu CC Tags: Int J Oncol Source Type: research
Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with...
Source: Phytotherapy Research - May 17, 2016 Category: Biochemistry Authors: Xiaoxv Dong, Jing Fu, Xingbin Yin, Sali Cao, Xuechun Li, Longfei Lin, , Jian Ni Tags: Review Source Type: research
Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia
Conclusions These results suggest that emodin may afford a significant neuroprotective effect against glutamate-induced apoptosis through activation of the PI3K/Akt signaling pathway, and subsequently enhance behavioral function in cerebral ischemia. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 11, 2016 Category: Drugs & Pharmacology Source Type: research
Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb
Volume 18, Issue 9, September 2016, pages 813-82210.1080/10286020.2016.1171758Jian-Bo Yang (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - May 2, 2016 Category: Complementary Medicine Authors: Jian-Bo YangLi LiZhong DaiYu WuXing-Chao GengBo LiShuang-Cheng MaAi-Guo WangYa-Lun Su Source Type: research
Integrated chemometric fingerprints of antioxidant activities and HPLC–DAD–CL for assessing the quality of the processed roots of Polygonum multiflorum Thunb. (Heshouwu)
The processed roots of Polygonum multiflorum Thunb. (Heshouwu; processed HSW) are commonly used in anti-aging medicine. Few reports have combined chemical profiles with bioactivity to evaluate the quality of the ... (Source: Chinese Medicine)
Source: Chinese Medicine - April 12, 2016 Category: Complementary Medicine Authors: Hai Fang Chen, You Hua Chen, Chun Hua Liu, Lu Wang, Xi Chen, Bo Yang Yu and Jin Qi Source Type: research
A Bioactivity-Based Method for Screening, Identification of Lipase Inhibitors, and Clarifying the Effects of Processing Time on Lipase Inhibitory Activity of Polygonum Multiflorum.
In this study, a bioactivity-based method was developed and validated to screen lipase inhibitors and evaluate the effects of processing on the lipase inhibitory activity of TCM by ultrahigh performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and fraction collector (UHPLC/Q-TOF-MS-FC). The results showed that both Polygonum multiflorum and processed P. multiflorum extracts had inhibitory effect against lipase with IC50 values of 38.84 μg/mL and 190.6 μg/mL, respectively. Stilbenes, phenolic acid, flavonoids, and anthraquinones were considered to be the potential lipase inhibitor...
Source: Evidence-based Complementary and Alternative Medicine - March 2, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice
In this study, the authors investigated the beneficial effects of polygonum multiflorum Thunberg complex composition-12 (PMC-12), which is a mixture of four medicinal herbs, that is, Polygonum multiflorum, Polygala tenuifolia, Rehmannia glutinosa, and Acorus gramineus, on hippocampal neurogenesis, learning, and memory in mice. PMC-12 was orally administered to male C57BL/6 mice (5 weeks old) at 100 or 500mg/kg daily for 2 weeks. PMC-12 administration significantly was found to increase the proliferation of neural progenitor cells and the survival of newly-generated cells in the dentate gyrus. In the Morris water maze test,...
Source: Neuroscience Letters - February 28, 2016 Category: Neuroscience Source Type: research
Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma.
Abstract
The root of Polygonum multiflorum (also called He-Shou-Wu in Chinese) is a common herb and medicinal food in Asia used for its anti-aging properties. Our study investigated the therapeutic potential of an extract of the root of Polygonum multiflorum (PME) in allergic asthma by using a mouse model. Feeding of 0.5 and 1 mg/mouse PME inhibited ovalbumin (OVA)-induced allergic asthma symptoms, including airway inflammation, mucus production, and airway hyper-responsiveness (AHR), in a dose-dependent manner. To discern PME's mechanism of action, we examined the profile and cytokine production of inflam...
Source: The American Journal of Chinese Medicine - February 1, 2016 Category: Complementary Medicine Authors: Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R Tags: Am J Chin Med Source Type: research
Comparison between Chinese herbal medicine and western medicine‐induced liver injury of 1985 patients
ConclusionsThe causal relationship between CHM and liver injury is much complex and the clinical characteristics of DILI caused by CHM differ from those caused by WM. This article is protected by copyright. All rights reserved. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 1, 2016 Category: Gastroenterology Authors: Yun Zhu, Ming Niu, Jing Chen, Zheng‐sheng Zou, Zhi‐jie Ma, Shu‐hong Liu, Rui‐lin Wang, Ting‐ting He, Hai‐bo Song, Zhong‐xia Wang, Shi‐biao Pu, Xiao Ma, Li‐fu Wang, Zhao‐fang Bai, Yan‐ling Zhao, Yong‐gang Li, Jia‐bo Wang, Xiao‐h Tags: Original Article ‐ Hepatology (Clinical) Source Type: research
Quantitative analysis of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glycoside in wild Polygonum multiflorum and suspension cell cultures fed different precursors and elicitors
Publication date: March 2016 Source:Phytochemistry Letters, Volume 15 Author(s): Wanxia Xia, Lei Lei, Wei Zhao, Yifan Feng, Shujin Zhao Polygonum multiflorum suspension cultures were established from calli and characterized during a culture period of 18 days. Flow cytometry analysis indicated a stable ploidy level in the cultured cells. THSG content was measured in different parts of wild PM and cell cultures after the addition of 4 precursors (jasmonic acid, methyl jasmonate, salicylic acid, and silver nitrate) and 4 elicitors (l-phenylalanine, glucose, sodium pyruvate, and sodium bicarbonate). PM vines, ro...
Source: Phytochemistry Letters - January 19, 2016 Category: Chemistry Source Type: research
Molecules, Vol. 21, Pages 40: Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products
In order to quickly and simultaneously obtain the chemical profiles and control the quality of the root of Polygonum multiflorum Thumb. and its processed form, a rapid qualitative and quantitative method, using ultra-high-performance liquid chromatography coupled with electrospray ionization-linear ion trap-Orbitrap hybrid mass spectrometry (UHPLC-LTQ-Orbitrap MSn) has been developed. The analysis was performed within 10 min on an AcQuity UPLC™ BEH C18 column with a gradient elution of 0.1% formic acid-acetonitrile at flow rate of 400 μL/min. According to the fragmentation mechanism and high resolution MSn data, a diagn...
Source: Molecules - December 26, 2015 Category: Chemistry Authors: Teng-Hua WangJing ZhangXiao-Hui QiuJun-Qi BaiYou-Heng GaoWen Xu Tags: Article Source Type: research
Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying.
Abstract
Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this research. Hair pigmentogenesis promotion activities of Polygonum Multiflorum Radix (PMR, raw crude drug), Polygonum Multiflorum Radix Preparata (PMRP, processed crude drug), and their major chemical constituent TSG were investigated. The regulation effects of several cytokines and enzymes such as POMC, α...
Source: Biomed Res - December 9, 2015 Category: Research Authors: Han MN, Lu JM, Zhang GY, Yu J, Zhao RH Tags: Biomed Res Int Source Type: research
Principles of Differentiation and Prescription for Vitiligo in Traditional Chinese Medicine Based on a Literature Investigation
Conclusion: The most frequent syndromes of vitiligo are liver and kidney deficiency, Qi stagnation and blood stasis. Most TCM doctors prefer prescribing herbs with efficacy in tonifying the liver and kidney, activating blood and expelling wind in treating vitiligo.Integr Med Int 2015;2:149-156 (Source: Integrative Medicine International)
Source: Integrative Medicine International - December 3, 2015 Category: Complementary Medicine Source Type: research
