Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research
Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research
Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research
Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research
Polygonum multiflorum: Recent Updates on Newly isolated Compounds, Potential Hepatotoxic Compounds and Their Mechanisms
Publication date: Available online 21 January 2021Source: Journal of EthnopharmacologyAuthor(s): Tekleab Teka, Liming Wang, Jian Gao, Jiajia Mou, Guixiang Pan, Haiyang Yu, Xiumei Gao, Lifeng Han (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 26, 2021 Category: Drugs & Pharmacology Source Type: research
Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR- γ.
Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ.
Acta Pharmacol Sin. 2020 Dec 22;:
Authors: Meng YK, Li CY, Li RY, He LZ, Cui HR, Yin P, Zhang CE, Li PY, Sang XX, Wang Y, Niu M, Zhang YM, Guo YM, Sun R, Wang JB, Bai ZF, Xiao XH
PMID: 33353980 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 22, 2020 Category: Drugs & Pharmacology Authors: Meng YK, Li CY, Li RY, He LZ, Cui HR, Yin P, Zhang CE, Li PY, Sang XX, Wang Y, Niu M, Zhang YM, Guo YM, Sun R, Wang JB, Bai ZF, Xiao XH Tags: Acta Pharmacol Sin Source Type: research
Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ
Acta Pharmacologica Sinica, Published online: 22 December 2020; doi:10.1038/s41401-020-00592-2Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 22, 2020 Category: Drugs & Pharmacology Authors: Ya-kun Meng Chun-yu Li Rui-yu Li Lan-zhi He He-rong Cui Ping Yin Cong-en Zhang Peng-yan Li Xiu-xiu Sang Ya Wang Ming Niu Ya-ming Zhang Yu-ming Guo Rong Sun Jia-bo Wang Zhao-fang Bai Xiao-he Xiao Source Type: research
Lipidomics Analysis Indicates Disturbed Hepatocellular Lipid Metabolism in Reynoutria multiflora-Induced Idiosyncratic Liver Injury
The objective of this study was to profile the metabolic characteristics of lipids in injured liver of rats induced by HSW and to find out potential lipid biomarkers of toxic consequence. A lipopolysaccharide (LPS)-induced rat model of idiosyncratic drug-induced liver injury (IDILI) was constructed and evident liver injury caused by HSW was confirmed based on the combination of biochemical, morphological, and functional tests. A lipidomics method was developed for the first time to investigate the alteration of lipid metabolism in HSW-induced IDILI rat liver by using ultra-high-performance liquid chromatography/Q-exactive ...
Source: Frontiers in Pharmacology - December 21, 2020 Category: Drugs & Pharmacology Source Type: research
Advances in understanding the metabolites and metabolomics of Polygonum multiflorum Thunb: A mini review.
CONCLUSION: This review mainly outlines the metabolites and metabolomics of PM that have been identified in recent years. This study could help to clarify the potential hepatotoxic components and metabolic mechanisms of PM and provide a scientific reference for its safe clinical use in the future.
PMID: 33261537 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 30, 2020 Category: Drugs & Pharmacology Authors: Yang JB, Gao HY, Song YF, Liu Y, Wang Q, Wang Y, Ma SC, Cheng XL, Wei F Tags: Curr Drug Metab Source Type: research
Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology
Diabetes is a complex metabolic disease characterized by hyperglycemia, plaguing the whole world. However, the action mode of multi-component and multi-target for traditional Chinese medicine (TCM) could be a ... (Source: Chinese Medicine)
Source: Chinese Medicine - November 18, 2020 Category: Complementary Medicine Authors: Yunfei Song, Jianbo Yang, Wenguang Jing, Qi Wang, Yue Liu, Xianlong Cheng, Fei Ye, Jinying Tian, Feng Wei and Shuangcheng Ma Tags: Research Source Type: research
The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway.
In this study, emodin did not show antioxidant activity in DPPH radical and reducing power assays. However, it was found that emodin scavenged intracellular H2O2. Emodin increased not only tyrosinase activity but also melanin synthesis in vitro. Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence. Moreover, emodin suppressed ERK activation by SIRT1 and FOXO1. Thus, emodin promoted melanin syn...
Source: Natural Product Research - November 18, 2020 Category: Biochemistry Authors: Kim J, Kim MM Tags: Nat Prod Res Source Type: research
In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae.
In this study, we refined the zebrafish hepatotoxicity model with regard to the following endpoints: liver size, liver gray value, and the area of yolk sac. The levels of alanine aminotransferase, aspartate transaminase, albumin, and microRNAs-122 were evaluated to verify the model. Subsequently, this model was used to screen different extracts, components, and constituents of PM, including 70 % EtOH extracts of PM, four fractions from macroporous resin (components A, B, C, and D), and 19 compounds from component D. We found that emodin, chrysophanol, emodin-8-O-β-D-glucopyranoside, (cis)-emodin-emodin dianthrones, and (t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 1, 2020 Category: Drugs & Pharmacology Authors: Li HY, Yang JB, Li WF, Qiu CX, Hu G, Wang ST, Song YF, Gao HY, Liu Y, Wang Q, Wang Y, Cheng XL, Wei F, Jin HT, Ma SC Tags: Biomed Pharmacother Source Type: research
Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum.
This study will build a new foundation for further study on the hepatotoxic components and mechanism of PM.
PMID: 33062019 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 20, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Erratum to: Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum
The original version of this article unfortunately contained some mistakes.The panel of “LPS-/drug-” in Fig. 3B (Page 259), the panels of “LPS-/EtoAc+” and “LPS-/Residue+” in Supplementary Fig. 3 (Page 7 in the online supplementary materials) should be corrected. The authors apologize for this error and state that this does not change the scientific conclusions of the artic le in any way. (Source: Frontiers of Medicine)
Source: Frontiers of Medicine - September 11, 2020 Category: General Medicine Source Type: research
Tetrahydroxystilbene glucoside alleviates Ang Ⅱ-induced senescence of HUVECs via SIRT1.
In this study, the possible protective mechanism of TSG on human umbilical vein endothelial cells (HUVECs) senescence induced by angiotensin Ⅱ (Ang Ⅱ) was investigated. The results revealed that TSG pretreatment could reduce the percentage of senescence-associated-β-galactosidase (SA-β-gal) positive cells, and decrease the expression levels of the cellular senescence biomarkers, p53 and PAI-1 proteins. At the same time, the expression of SIRT1 in senescent cell showed an upward trend due to TSG treatment. When inhibiting the expression of SIRT1 by EX527, our results showed that TSG reversed the effect of EX527, by pr...
Source: Canadian Journal of Physiology and Pharmacology - September 7, 2020 Category: Drugs & Pharmacology Authors: Fan W, Guo Y, Cao S, Cao S, Xie Y, Liu X, Jin B Tags: Can J Physiol Pharmacol Source Type: research
