The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF- κB pathway
Can J Physiol Pharmacol. 2021 Oct 20. doi: 10.1139/cjpp-2021-0329. Online ahead of print.ABSTRACTFunctional and structural adaptation of common carotid artery could be one of the important causes of postflight orthostatic intolerance after microgravity exposure, the mechanisms of which remain unclear. Recent evidence indicates that long-term spaceflight increases carotid artery stiffness, which might present a high risk to astronaut health and postflight working ability. Studies have suggested that vascular calcification is a common pathological change in cardiovascular diseases that is mainly manifested as an increase in ...
Source: Canadian Journal of Physiology and Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Authors: Huan Liu Ning-Yu Ru Yue Cai Qiang Lyu Chi-Hua Guo Ying Zhou Shao-Hua Li Jiu-Hua Cheng Jin-Rui Chang Jin Ma Xing-Li Su Source Type: research

The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF- κB pathway
Can J Physiol Pharmacol. 2021 Oct 20. doi: 10.1139/cjpp-2021-0329. Online ahead of print.ABSTRACTFunctional and structural adaptation of common carotid artery could be one of the important causes of postflight orthostatic intolerance after microgravity exposure, the mechanisms of which remain unclear. Recent evidence indicates that long-term spaceflight increases carotid artery stiffness, which might present a high risk to astronaut health and postflight working ability. Studies have suggested that vascular calcification is a common pathological change in cardiovascular diseases that is mainly manifested as an increase in ...
Source: Canadian Journal of Physiology and Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Authors: Huan Liu Ning-Yu Ru Yue Cai Qiang Lyu Chi-Hua Guo Ying Zhou Shao-Hua Li Jiu-Hua Cheng Jin-Rui Chang Jin Ma Xing-Li Su Source Type: research

The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF- κB pathway
Can J Physiol Pharmacol. 2021 Oct 20. doi: 10.1139/cjpp-2021-0329. Online ahead of print.ABSTRACTFunctional and structural adaptation of common carotid artery could be one of the important causes of postflight orthostatic intolerance after microgravity exposure, the mechanisms of which remain unclear. Recent evidence indicates that long-term spaceflight increases carotid artery stiffness, which might present a high risk to astronaut health and postflight working ability. Studies have suggested that vascular calcification is a common pathological change in cardiovascular diseases that is mainly manifested as an increase in ...
Source: Canadian Journal of Physiology and Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Authors: Huan Liu Ning-Yu Ru Yue Cai Qiang Lyu Chi-Hua Guo Ying Zhou Shao-Hua Li Jiu-Hua Cheng Jin-Rui Chang Jin Ma Xing-Li Su Source Type: research

Protective effect of Apelin-13 in a cyclophosphamide-induced cardiorenal toxicity model in rats
In this study, a total of 4 groups were formed, including 8 rats in each group. Group 1: The control group was administered only saline (ip). Group 2: Cyclophosphamide, a single dose of 200 mg/kg (ip) on day 7. Group 3: Apelin-13 (15 μg/kg), for 7 days (ip). Group 4: Administering apelin-13 (15 μg/kg) (ip) for 7 days and a single dose of cyclophosphamide (200 mg/kg) (ip) on day 7, the rats were sacrificed on day 8. LDH, cTn1, cK-Mb, AST, ALT, ALP, MDA, creatinine, and BUN were found to be high in the cyclophosphamide group, however, these values were reduced with apelin-13 administration. Antioxidant enzymes such as ...
Source: Canadian Journal of Physiology and Pharmacology - October 19, 2021 Category: Drugs & Pharmacology Authors: Özden Kutlay Arzu Keskin-Aktan Esra Aslan Source Type: research

Protective effect of Apelin-13 in a cyclophosphamide-induced cardiorenal toxicity model in rats
In this study, a total of 4 groups were formed, including 8 rats in each group. Group 1: The control group was administered only saline (ip). Group 2: Cyclophosphamide, a single dose of 200 mg/kg (ip) on day 7. Group 3: Apelin-13 (15 μg/kg), for 7 days (ip). Group 4: Administering apelin-13 (15 μg/kg) (ip) for 7 days and a single dose of cyclophosphamide (200 mg/kg) (ip) on day 7, the rats were sacrificed on day 8. LDH, cTn1, cK-Mb, AST, ALT, ALP, MDA, creatinine, and BUN were found to be high in the cyclophosphamide group, however, these values were reduced with apelin-13 administration. Antioxidant enzymes such as ...
Source: Canadian Journal of Physiology and Pharmacology - October 19, 2021 Category: Drugs & Pharmacology Authors: Özden Kutlay Arzu Keskin-Aktan Esra Aslan Source Type: research

Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat
Can J Physiol Pharmacol. 2021 Oct 13. doi: 10.1139/cjpp-2021-0385. Online ahead of print.ABSTRACTThe arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GC). It has been suggested that GC may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in e...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: Tatiana Sergeevna Tumanova Tatiana Nikolaevna Кokurina Galina Ivanovna Rybakova Viacheslav G Aleksandrov Source Type: research

Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat
Can J Physiol Pharmacol. 2021 Oct 13. doi: 10.1139/cjpp-2021-0385. Online ahead of print.ABSTRACTThe arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GC). It has been suggested that GC may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in e...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: Tatiana Sergeevna Tumanova Tatiana Nikolaevna Кokurina Galina Ivanovna Rybakova Viacheslav G Aleksandrov Source Type: research

Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat
Can J Physiol Pharmacol. 2021 Oct 13. doi: 10.1139/cjpp-2021-0385. Online ahead of print.ABSTRACTThe arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GC). It has been suggested that GC may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in e...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: Tatiana Sergeevna Tumanova Tatiana Nikolaevna Кokurina Galina Ivanovna Rybakova Viacheslav G Aleksandrov Source Type: research

Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat
Can J Physiol Pharmacol. 2021 Oct 13. doi: 10.1139/cjpp-2021-0385. Online ahead of print.ABSTRACTThe arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GC). It has been suggested that GC may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in e...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: Tatiana Sergeevna Tumanova Tatiana Nikolaevna Кokurina Galina Ivanovna Rybakova Viacheslav G Aleksandrov Source Type: research

Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat
Can J Physiol Pharmacol. 2021 Oct 13. doi: 10.1139/cjpp-2021-0385. Online ahead of print.ABSTRACTThe arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GC). It has been suggested that GC may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in e...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2021 Category: Drugs & Pharmacology Authors: Tatiana Sergeevna Tumanova Tatiana Nikolaevna Кokurina Galina Ivanovna Rybakova Viacheslav G Aleksandrov Source Type: research

Effect of ivabradine in heart failure: a meta-analysis of heart failure patients with reduced versus preserved ejection fraction
Can J Physiol Pharmacol. 2021 Oct 12:1-16. doi: 10.1139/cjpp-2020-0700. Online ahead of print.ABSTRACTIn clinical trials of heart failure reduced ejection fraction (HFrEF), ivabradine seemed to be an effective heart rate lowering agent associated with lower risk of cardiovascular death. In contrast, ivabradine failed to improve cardiovascular outcomes in heart failure preserved ejection fraction (HFpEF) despite the significant effect on heart rate. This meta-analysis is the first to compare the effects of ivabradine on heart rate and mortality parameters in HFpEF versus HFrEF. We screened three databases: PubMed, Embase, a...
Source: Canadian Journal of Physiology and Pharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: No émi Tóth Alexandra So ós Alex V áradi P éter Hegyi Benedek Tinusz Anna V ágvölgyi Andrea Orosz Margit Solym ár Alexandra Poly ák Andr ás Varró Attila S Farkas Norbert Nagy Source Type: research

Corrigendum: Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4
Can J Physiol Pharmacol. 2021 Mar;99(3):348. doi: 10.1139/cjpp-2020-0752. Epub 2021 Mar 9.NO ABSTRACTPMID:34637362 | DOI:10.1139/cjpp-2020-0752 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Yunpeng Tian Wei Lv Chengzhi Lu Yiyao Jiang Xue Yang Haoming Song Source Type: research

Effect of ivabradine in heart failure: a meta-analysis of heart failure patients with reduced versus preserved ejection fraction
Can J Physiol Pharmacol. 2021 Oct 12:1-16. doi: 10.1139/cjpp-2020-0700. Online ahead of print.ABSTRACTIn clinical trials of heart failure reduced ejection fraction (HFrEF), ivabradine seemed to be an effective heart rate lowering agent associated with lower risk of cardiovascular death. In contrast, ivabradine failed to improve cardiovascular outcomes in heart failure preserved ejection fraction (HFpEF) despite the significant effect on heart rate. This meta-analysis is the first to compare the effects of ivabradine on heart rate and mortality parameters in HFpEF versus HFrEF. We screened three databases: PubMed, Embase, a...
Source: Canadian Journal of Physiology and Pharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: No émi Tóth Alexandra So ós Alex V áradi P éter Hegyi Benedek Tinusz Anna V ágvölgyi Andrea Orosz Margit Solym ár Alexandra Poly ák Andr ás Varró Attila S Farkas Norbert Nagy Source Type: research

Corrigendum: Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4
Can J Physiol Pharmacol. 2021 Mar;99(3):348. doi: 10.1139/cjpp-2020-0752. Epub 2021 Mar 9.NO ABSTRACTPMID:34637362 | DOI:10.1139/cjpp-2020-0752 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Yunpeng Tian Wei Lv Chengzhi Lu Yiyao Jiang Xue Yang Haoming Song Source Type: research

The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1 α pathway in isolated beating rat atria
In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced atrial natriuretic peptide (ANP) secretion. Radioimmunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor 1α (HIF-1α), and GATA4 in the atrial tissue. The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 μM). By Western blotting...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Qiu-Li Zhang Ping Li Lan Hong Rui-Zhuang Li Jia-Qi Wang Xun Cui Source Type: research

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals
In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.PMID:34614364 | DOI:10.1139/cjpp-2021-0457 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Marco Fiore Luigi Tarani Antonio Radicioni Matteo Spaziani Giampiero Ferraguti Carolina Putotto Francesca Gabanella Daniela Maftei Roberta Lattanzi Antonio Minni Antonio Greco Francesca Tarani Carla Petrella Source Type: research

Systemic study of selected HDAC inhibitors in cardiac complications associated with cancer cachexia
Can J Physiol Pharmacol. 2021 Oct 6. doi: 10.1139/cjpp-2021-0012. Online ahead of print.ABSTRACTCancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metas...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Vivek Bora Dhwani Patel Kaid Johar Ramesh K Goyal Bhoomika Mayur Patel Source Type: research

The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1 α pathway in isolated beating rat atria
In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced atrial natriuretic peptide (ANP) secretion. Radioimmunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor 1α (HIF-1α), and GATA4 in the atrial tissue. The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 μM). By Western blotting...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Qiu-Li Zhang Ping Li Lan Hong Rui-Zhuang Li Jia-Qi Wang Xun Cui Source Type: research

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals
In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.PMID:34614364 | DOI:10.1139/cjpp-2021-0457 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Marco Fiore Luigi Tarani Antonio Radicioni Matteo Spaziani Giampiero Ferraguti Carolina Putotto Francesca Gabanella Daniela Maftei Roberta Lattanzi Antonio Minni Antonio Greco Francesca Tarani Carla Petrella Source Type: research

Systemic study of selected HDAC inhibitors in cardiac complications associated with cancer cachexia
Can J Physiol Pharmacol. 2021 Oct 6. doi: 10.1139/cjpp-2021-0012. Online ahead of print.ABSTRACTCancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metas...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Vivek Bora Dhwani Patel Kaid Johar Ramesh K Goyal Bhoomika Mayur Patel Source Type: research

The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1 α pathway in isolated beating rat atria
In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced atrial natriuretic peptide (ANP) secretion. Radioimmunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor 1α (HIF-1α), and GATA4 in the atrial tissue. The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 μM). By Western blotting...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Qiu-Li Zhang Ping Li Lan Hong Rui-Zhuang Li Jia-Qi Wang Xun Cui Source Type: research

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals
In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.PMID:34614364 | DOI:10.1139/cjpp-2021-0457 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Marco Fiore Luigi Tarani Antonio Radicioni Matteo Spaziani Giampiero Ferraguti Carolina Putotto Francesca Gabanella Daniela Maftei Roberta Lattanzi Antonio Minni Antonio Greco Francesca Tarani Carla Petrella Source Type: research

Systemic study of selected HDAC inhibitors in cardiac complications associated with cancer cachexia
Can J Physiol Pharmacol. 2021 Oct 6. doi: 10.1139/cjpp-2021-0012. Online ahead of print.ABSTRACTCancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metas...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Vivek Bora Dhwani Patel Kaid Johar Ramesh K Goyal Bhoomika Mayur Patel Source Type: research

The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1 α pathway in isolated beating rat atria
In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced atrial natriuretic peptide (ANP) secretion. Radioimmunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor 1α (HIF-1α), and GATA4 in the atrial tissue. The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 μM). By Western blotting...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Qiu-Li Zhang Ping Li Lan Hong Rui-Zhuang Li Jia-Qi Wang Xun Cui Source Type: research

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals
In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.PMID:34614364 | DOI:10.1139/cjpp-2021-0457 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Marco Fiore Luigi Tarani Antonio Radicioni Matteo Spaziani Giampiero Ferraguti Carolina Putotto Francesca Gabanella Daniela Maftei Roberta Lattanzi Antonio Minni Antonio Greco Francesca Tarani Carla Petrella Source Type: research

Systemic study of selected HDAC inhibitors in cardiac complications associated with cancer cachexia
Can J Physiol Pharmacol. 2021 Oct 6. doi: 10.1139/cjpp-2021-0012. Online ahead of print.ABSTRACTCancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metas...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Vivek Bora Dhwani Patel Kaid Johar Ramesh K Goyal Bhoomika Mayur Patel Source Type: research

The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1 α pathway in isolated beating rat atria
In this study, we established a rat model of isolated beating atrium and investigated the regulator role of genistein and its downstream signaling pathways in acute hypoxia-induced atrial natriuretic peptide (ANP) secretion. Radioimmunoassay was used to detect the ANP content in the atrial perfusates. Western blot analysis was used to determine the protein level of hypoxia-inducible factor 1α (HIF-1α), and GATA4 in the atrial tissue. The results showed that acute hypoxia substantially promoted ANP secretion, whereas this effect was partly attenuated by the PTKs inhibitor genistein (3 μM). By Western blotting...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Qiu-Li Zhang Ping Li Lan Hong Rui-Zhuang Li Jia-Qi Wang Xun Cui Source Type: research

Serum Prokineticin-2 in Prepubertal and Adult Klinefelter Individuals
In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.PMID:34614364 | DOI:10.1139/cjpp-2021-0457 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Marco Fiore Luigi Tarani Antonio Radicioni Matteo Spaziani Giampiero Ferraguti Carolina Putotto Francesca Gabanella Daniela Maftei Roberta Lattanzi Antonio Minni Antonio Greco Francesca Tarani Carla Petrella Source Type: research

Systemic study of selected HDAC inhibitors in cardiac complications associated with cancer cachexia
Can J Physiol Pharmacol. 2021 Oct 6. doi: 10.1139/cjpp-2021-0012. Online ahead of print.ABSTRACTCancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metas...
Source: Canadian Journal of Physiology and Pharmacology - October 6, 2021 Category: Drugs & Pharmacology Authors: Vivek Bora Dhwani Patel Kaid Johar Ramesh K Goyal Bhoomika Mayur Patel Source Type: research

Effects of Phytocannabinoids on Heart Rate Variability and Blood Pressure Variability in Female Post-Concussion Syndrome Patients: Case Series
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0395. Online ahead of print.ABSTRACTCannabidiol (CBD) can exert neuroprotective effects without being intoxicating, and in combination with ∆9-tetrahydrocannabinol (THC), CBD has shown to protect against THC psychosis. Acute concussion and post-concussion syndrome (PCS) can result in autonomic dysfunction in heart rate variability (HRV), but less information is available on blood pressure variability (BPV). Furthermore, the effects of phytocannabinoids on HRV and BPV in PCS are unknown. The purpose of this study was to observe the influence of daily administrati...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Jyotpal Singh Lanishen Bhagaloo Jaroslaw Piskorski J Patrick Neary Source Type: research

Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0199. Online ahead of print.ABSTRACTApoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death. AIF cleavage and translocation to the cytosol is thought to be calpain-1-dependent as calpain inhibitors reduced AIF proteolysis. However, many calpain inhibitors also inhibit matrix metalloproteinase-2 (MMP-2) activity, an intracellular and extracellular protease implicated in apoptosis. Here we investigated whether MMP-2 activity is affected in response to STS and if contributes to AIF cleavage. Human fibrosar...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Wesam Bassiouni John M Seubert Richard Schulz Source Type: research

Effects of Phytocannabinoids on Heart Rate Variability and Blood Pressure Variability in Female Post-Concussion Syndrome Patients: Case Series
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0395. Online ahead of print.ABSTRACTCannabidiol (CBD) can exert neuroprotective effects without being intoxicating, and in combination with ∆9-tetrahydrocannabinol (THC), CBD has shown to protect against THC psychosis. Acute concussion and post-concussion syndrome (PCS) can result in autonomic dysfunction in heart rate variability (HRV), but less information is available on blood pressure variability (BPV). Furthermore, the effects of phytocannabinoids on HRV and BPV in PCS are unknown. The purpose of this study was to observe the influence of daily administrati...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Jyotpal Singh Lanishen Bhagaloo Jaroslaw Piskorski J Patrick Neary Source Type: research

Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0199. Online ahead of print.ABSTRACTApoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death. AIF cleavage and translocation to the cytosol is thought to be calpain-1-dependent as calpain inhibitors reduced AIF proteolysis. However, many calpain inhibitors also inhibit matrix metalloproteinase-2 (MMP-2) activity, an intracellular and extracellular protease implicated in apoptosis. Here we investigated whether MMP-2 activity is affected in response to STS and if contributes to AIF cleavage. Human fibrosar...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Wesam Bassiouni John M Seubert Richard Schulz Source Type: research

Effects of Phytocannabinoids on Heart Rate Variability and Blood Pressure Variability in Female Post-Concussion Syndrome Patients: Case Series
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0395. Online ahead of print.ABSTRACTCannabidiol (CBD) can exert neuroprotective effects without being intoxicating, and in combination with ∆9-tetrahydrocannabinol (THC), CBD has shown to protect against THC psychosis. Acute concussion and post-concussion syndrome (PCS) can result in autonomic dysfunction in heart rate variability (HRV), but less information is available on blood pressure variability (BPV). Furthermore, the effects of phytocannabinoids on HRV and BPV in PCS are unknown. The purpose of this study was to observe the influence of daily administrati...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Jyotpal Singh Lanishen Bhagaloo Jaroslaw Piskorski J Patrick Neary Source Type: research

Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0199. Online ahead of print.ABSTRACTApoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death. AIF cleavage and translocation to the cytosol is thought to be calpain-1-dependent as calpain inhibitors reduced AIF proteolysis. However, many calpain inhibitors also inhibit matrix metalloproteinase-2 (MMP-2) activity, an intracellular and extracellular protease implicated in apoptosis. Here we investigated whether MMP-2 activity is affected in response to STS and if contributes to AIF cleavage. Human fibrosar...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Wesam Bassiouni John M Seubert Richard Schulz Source Type: research

Effects of Phytocannabinoids on Heart Rate Variability and Blood Pressure Variability in Female Post-Concussion Syndrome Patients: Case Series
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0395. Online ahead of print.ABSTRACTCannabidiol (CBD) can exert neuroprotective effects without being intoxicating, and in combination with ∆9-tetrahydrocannabinol (THC), CBD has shown to protect against THC psychosis. Acute concussion and post-concussion syndrome (PCS) can result in autonomic dysfunction in heart rate variability (HRV), but less information is available on blood pressure variability (BPV). Furthermore, the effects of phytocannabinoids on HRV and BPV in PCS are unknown. The purpose of this study was to observe the influence of daily administrati...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Jyotpal Singh Lanishen Bhagaloo Jaroslaw Piskorski J Patrick Neary Source Type: research

Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2
Can J Physiol Pharmacol. 2021 Oct 1. doi: 10.1139/cjpp-2021-0199. Online ahead of print.ABSTRACTApoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death. AIF cleavage and translocation to the cytosol is thought to be calpain-1-dependent as calpain inhibitors reduced AIF proteolysis. However, many calpain inhibitors also inhibit matrix metalloproteinase-2 (MMP-2) activity, an intracellular and extracellular protease implicated in apoptosis. Here we investigated whether MMP-2 activity is affected in response to STS and if contributes to AIF cleavage. Human fibrosar...
Source: Canadian Journal of Physiology and Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Authors: Wesam Bassiouni John M Seubert Richard Schulz Source Type: research

Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study
Can J Physiol Pharmacol. 2021 Oct;99(10):1114-1115. doi: 10.1139/cjpp-2021-0031.NO ABSTRACTPMID:34585956 | DOI:10.1139/cjpp-2021-0031 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Casper Falster Svend Korfitzen Martin Herold Jan Lindebjerg Morten Els øe Source Type: research

Reply to "Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study"
Can J Physiol Pharmacol. 2021 Oct;99(10):1116-1117. doi: 10.1139/cjpp-2021-0151.NO ABSTRACTPMID:34585957 | DOI:10.1139/cjpp-2021-0151 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Shigeo Ohta Tyler W LeBaron Source Type: research

Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: Novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats
Can J Physiol Pharmacol. 2021 Sep 29. doi: 10.1139/cjpp-2021-0170. Online ahead of print.ABSTRACTPersistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. Since hyperglycemia damages the endothelial layer via multiple signaling pathways, including enhanced oxidative stress, downregulation of angiotensin-converting enzyme2 signaling, and exacerbation of endoplasmic reticulum stress, etc.; hence it becomes difficult to prevent the injury using monotherapy. Thus, the present study was conceived to evaluate the combined effect of endoplasmic reticulum stre...
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Himanshu Sankrityayan Ajinath Kale Anil Bhanudas Gaikwad Source Type: research

Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study
Can J Physiol Pharmacol. 2021 Oct;99(10):1114-1115. doi: 10.1139/cjpp-2021-0031.NO ABSTRACTPMID:34585956 | DOI:10.1139/cjpp-2021-0031 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Casper Falster Svend Korfitzen Martin Herold Jan Lindebjerg Morten Els øe Source Type: research

Reply to "Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study"
Can J Physiol Pharmacol. 2021 Oct;99(10):1116-1117. doi: 10.1139/cjpp-2021-0151.NO ABSTRACTPMID:34585957 | DOI:10.1139/cjpp-2021-0151 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Shigeo Ohta Tyler W LeBaron Source Type: research

Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: Novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats
Can J Physiol Pharmacol. 2021 Sep 29. doi: 10.1139/cjpp-2021-0170. Online ahead of print.ABSTRACTPersistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. Since hyperglycemia damages the endothelial layer via multiple signaling pathways, including enhanced oxidative stress, downregulation of angiotensin-converting enzyme2 signaling, and exacerbation of endoplasmic reticulum stress, etc.; hence it becomes difficult to prevent the injury using monotherapy. Thus, the present study was conceived to evaluate the combined effect of endoplasmic reticulum stre...
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Himanshu Sankrityayan Ajinath Kale Anil Bhanudas Gaikwad Source Type: research

Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study
Can J Physiol Pharmacol. 2021 Oct;99(10):1114-1115. doi: 10.1139/cjpp-2021-0031.NO ABSTRACTPMID:34585956 | DOI:10.1139/cjpp-2021-0031 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Casper Falster Svend Korfitzen Martin Herold Jan Lindebjerg Morten Els øe Source Type: research

Reply to "Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study"
Can J Physiol Pharmacol. 2021 Oct;99(10):1116-1117. doi: 10.1139/cjpp-2021-0151.NO ABSTRACTPMID:34585957 | DOI:10.1139/cjpp-2021-0151 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Shigeo Ohta Tyler W LeBaron Source Type: research

Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: Novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats
Can J Physiol Pharmacol. 2021 Sep 29. doi: 10.1139/cjpp-2021-0170. Online ahead of print.ABSTRACTPersistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. Since hyperglycemia damages the endothelial layer via multiple signaling pathways, including enhanced oxidative stress, downregulation of angiotensin-converting enzyme2 signaling, and exacerbation of endoplasmic reticulum stress, etc.; hence it becomes difficult to prevent the injury using monotherapy. Thus, the present study was conceived to evaluate the combined effect of endoplasmic reticulum stre...
Source: Canadian Journal of Physiology and Pharmacology - September 29, 2021 Category: Drugs & Pharmacology Authors: Himanshu Sankrityayan Ajinath Kale Anil Bhanudas Gaikwad Source Type: research

L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia
Can J Physiol Pharmacol. 2021 Sep 28:1-11. doi: 10.1139/cjpp-2021-0247. Online ahead of print.ABSTRACTType-2 diabetes (T2D) is associated with liver toxicity. L-ergothioneine (L-egt) has been reported to reduce toxicity in tissues exposed to injury, while metformin is commonly prescribed to manage T2D. Hence, this study evaluates the hepatoprotective role of L-egt, with or without metformin, in T2D male rats. A total of 36 adult male Sprague-Dawley rats were randomly divided into non-diabetic (n = 12) and diabetic (n = 24) groups. After induction of diabetes, animals were divided into six groups (n = 6) and treated orally ...
Source: Canadian Journal of Physiology and Pharmacology - September 28, 2021 Category: Drugs & Pharmacology Authors: Ayobami Dare Mahendra L Channa Anand Nadar Source Type: research

L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia
Can J Physiol Pharmacol. 2021 Sep 28:1-11. doi: 10.1139/cjpp-2021-0247. Online ahead of print.ABSTRACTType-2 diabetes (T2D) is associated with liver toxicity. L-ergothioneine (L-egt) has been reported to reduce toxicity in tissues exposed to injury, while metformin is commonly prescribed to manage T2D. Hence, this study evaluates the hepatoprotective role of L-egt, with or without metformin, in T2D male rats. A total of 36 adult male Sprague-Dawley rats were randomly divided into non-diabetic (n = 12) and diabetic (n = 24) groups. After induction of diabetes, animals were divided into six groups (n = 6) and treated orally ...
Source: Canadian Journal of Physiology and Pharmacology - September 28, 2021 Category: Drugs & Pharmacology Authors: Ayobami Dare Mahendra L Channa Anand Nadar Source Type: research

Acute and chronic metabolic effects of carvedilol in high-fructose, high fat diet-fed mice: Implication of β-arrestin2 pathway
In conclusion, carvedilol acutely maintains glucose homeostasis and chronically ameliorates insulin resistance and dyslipidemia in HFrHFD-fed mice. The insulin sensitizing effects of carvedilol are highly correlated with the upregulation of β-arrestin2 pathway.PMID:34570983 | DOI:10.1139/cjpp-2021-0299 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 27, 2021 Category: Drugs & Pharmacology Authors: Hoda M S Ahmed Samar G Mohamed Wael S Ibrahim Asmaa M Rezk Amr A A Mahmoud Mona F Mahmoud Islam Ibrahim Source Type: research

Nanoparticles eluting stents for coronary intervention: Formulation, characterization and in vitro evaluation
Can J Physiol Pharmacol. 2021 Sep 27. doi: 10.1139/cjpp-2021-0245. Online ahead of print.ABSTRACTCoronary artery disease (CAD) is currently a leading cause of death worldwide. In the history of percutaneous coronary intervention for the treatment of CAD, a drug-eluting stent (DES) is recognized as a revolutionary technology that has the unique ability to significantly reduce restenosis and provide both mechanical and biological solutions simultaneously to the target lesion. The aim of the research work was to design and fabricate DES coated with a nanoparticulate drug formulation. Sirolimus, an inhibitor of the smooth musc...
Source: Canadian Journal of Physiology and Pharmacology - September 27, 2021 Category: Drugs & Pharmacology Authors: Ankit Agrawal Ankur Raval Shilpa Velhal Vainav Patel Vandana Patravale Source Type: research