Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats
The incidence of insulin resistance (IR) has rapidly increased worldwide over the last 20 years, no perfect solution has yet been identified. Finding new therapeutic drugs will help improve this situation. As ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 5, 2020 Category: Complementary Medicine Authors: Wen Gu, Min Yang, Qian Bi, Lin-Xi Zeng, Xi Wang, Jin-Cai Dong, Feng-Jiao Li, Xing-Xin Yang, Jing-Ping Li and Jie Yu Tags: Research article Source Type: research
Effects of Different Processed Products of Polygonum multiflorum on the Liver.
Conclusion: The content of the main components in Radix Polygonum multiflorum can be affected by processing time; stilbene glycoside may be the main component leading to liver injury. The degree of liver injury caused by Radix Polygonum multiflorum is negatively correlated with processing time.Polygonum multiflorum and different processed products and their effects on hepatotoxicity were investigated. Polygonum multiflorum and different processed products and their effects on hepatotoxicity were investigated.
PMID: 32215041 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 28, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population.
CONCLUSION: rs111686806, rs1055348, and rs202047044 are associated with PM-DILI, of which, rs1055348 is specific to PM-DILI. As a tag for HLA-B*35:01, rs1055348 may become an alternative predictive biomarker of PM-DILI.
PMID: 32256020 [PubMed - as supplied by publisher] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 27, 2020 Category: Gastroenterology Authors: Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L, Wang SY, Liu XZ, Tan KA, Shi WW, Wang GQ, Hou FQ Tags: World J Gastroenterol Source Type: research
The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury.
Abstract
Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liver injury (PM-DILI) is considered to be immune-mediated idiosyncratic liver injury, but the role of immune response and the underlying mechanisms are not completely elucidated. Previous studies focused on the direct toxicity of PM-DILI by using animal models with intrinsic drug-induce...
Source: Acta Pharmacologica Sinica - March 1, 2020 Category: Drugs & Pharmacology Authors: Rao T, Liu YT, Zeng XC, Li CP, Ou-Yang DS Tags: Acta Pharmacol Sin Source Type: research
The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury
Acta Pharmacologica Sinica, Published online: 02 March 2020; doi:10.1038/s41401-020-0360-3The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 1, 2020 Category: Drugs & Pharmacology Authors: Tai Rao Ya-ting Liu Xiang-chang Zeng Chao-peng Li Dong-sheng Ou-Yang Source Type: research
A review on the extraction, purification, detection, and pharmacological effects of 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum multiflorum
Publication date: April 2020Source: Biomedicine & Pharmacotherapy, Volume 124Author(s): Jin Qian, Mingqi Hou, Xian Wu, Chuanying Dai, Jiaqiang Sun, Liuyi DongAbstract2,3,5,4,-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG) is the main active constituent of the traditional Chinese medicine, Polygonum multiflorum; it was discovered that the compound has various biological activities and medicinal value including anti-aging, antioxidative (via scavenging free radicals), antihypercholesterolemic, anti-atherosclerotic, anti-inflammatory, hepatoprotective, and anti-tumor effects. TSG aids in prevention and treatment of Alzheimer's...
Source: Biomedicine and Pharmacotherapy - January 25, 2020 Category: Drugs & Pharmacology Source Type: research
[ASAP] Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of < italic toggle="yes" > Polygonum multiflorum < /italic >
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00777 (Source: Journal of Natural Products)
Source: Journal of Natural Products - January 16, 2020 Category: Biochemistry Authors: Thi-Thuy An Nguyen †?, Manh Tuan Ha‡?, Se-Eun Park§, Jae Sue Choi§, Byung Sun Min*‡, and Jeong Ah Kim*† Source Type: research
2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside alleviated the acute hepatotoxicity and DNA damage in diethylnitrosamine-contaminated mice
This study aimed at investigating the effect of TSG on diethylnitrosamine (DEN)-induced acute hepatotoxicity and DNA damage.Main methodsFifty male C57BL/6 mice were randomly divided into 5 groups (n = 10 each): control, DEN, DEN+TSG (low), DEN+TSG (high) and TSG (high) groups. DEN (100 mg/kg) was injected intraperitoneally (i.p.) alone or with TSG (30 or 60 mg/kg, i.p.) for 5 consecutive days.Key findingsTSG inhibited liver injury and inflammatory cell infiltration in DEN-treated mice. It also attenuated DEN-induced accumulation of reactive oxygen species (ROS), proinflammatory cytokines, and DNA damage. Moreover, ...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research
Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges
This study was aimed at reviewing the status of research on liver injury due to PM, including clinical characteristics, risk factors, material basis research and mechanism of action, with a view to understanding PM-induced hepatotoxicity, and taking reasonable and effective measures to prevent it. In short, quality control is still one of the major safety problems in TCM drug safety concerns. The model of safety monitoring and risk management of PM drugs is not yet developed. Indeed, the characteristics and risk factors associated with PM require both proper understanding and control of the risk by strengthening standardiz...
Source: Frontiers in Pharmacology - December 12, 2019 Category: Drugs & Pharmacology Source Type: research
Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum.
Abstract
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction. To date, identifying individuals at risk for IDILI remains challenging. This is a prospective study, where a nested case-control (1:5) design was adopted. For six patients who had abnormalities in liver function test after Polygonum multiflorum Thunb. (PM) ingestion (susceptible group), 30 patients with normal liver function were matched (tolerant group). Based on liquid chromatography-mass spectrometry, metabolomics analysis was done on serum samples prior to PM ingestion, to screen the differe...
Source: Archives of Toxicology - October 18, 2019 Category: Toxicology Authors: Zhang L, Niu M, Wei AW, Tang JF, Tu C, Bai ZF, Zou ZS, Xiao XH, Liu YP, Wang JB Tags: Arch Toxicol Source Type: research
Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE−/− mice
ConclusionPMRP and TSG improved lipid accumulation and inflammation, and regulated the intestinal microbial imbalance in ApoE−/- mice. TSG exerted a preventive effect in the development and progression of AS.Graphical abstractInflammation Inhibition and Gut Microbiota Regulation of TSG on in ApoE−/- Mice, Fengjiao Li, Ting Zhang, Yanran He et al. JEP_112232. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 12, 2019 Category: Drugs & Pharmacology Source Type: research
Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum.
In this study, we elucidated the contribution of the two major compounds, emodin-8-O-β-D-glucoside (EG) and 2,3,5,4´-tetrahydroxyl diphenylethylene-2-O-glucoside (TSG), in PM-induced liver injury. 2. Based on LC-MS, the two concerned compounds were detected simultaneously in the sera of patients with PM-induced liver injury. In the lipopolysaccharide (LPS)-mediated inflammatory stress rat model, by the analysis of plasma biochemistry and liver histopathology, we observed that the solo treatment of EG, not TSG, could induce significant liver injury; and the combined administration of EG and TSG caused more severe liver in...
Source: Xenobiotica - August 18, 2019 Category: Research Authors: Zhang L, Liu X, Tu C, Li C, Song D, Zhu J, Zhou Y, Wang X, Li R, Xiao X, Liu Y, Wang J Tags: Xenobiotica Source Type: research
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
In conclusion, these results indicated that emodin could induce apoptosis in an SREBP1-dependent and SREBP1-independent manner in hepatocellular carcinoma cells. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 24, 2019 Category: Drugs & Pharmacology Source Type: research
Effect of Polygonum Multiflorum Thunb on liver fatty acid content in aging mice induced by D-galactose
Polygonum Multiflorum Thunb(PMT) has multiple biological effects, such as anti-inflammatory, lipid-lowering, anti-aging and so on. Therefore, D-galactose-induced aging mice were used to study the effect of PMT on... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 1, 2019 Category: Lipidology Authors: Jiangquan Yang, Yuqi He, Jiayi Zou, Lin Xu, Fang Fan and Zhenglong Ge Tags: Research Source Type: research
Neuroprotection by 2,3,5,4 ʹ-tetrahydroxystilbene-2-O- & beta;-D-glucoside extracts from Polygonum multiflorum against cerebral ischemia/reperfusion injury through the 5-hydroxytryptamine/5-hydroxytryptamine receptor pathway
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - May 27, 2019 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
