Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro
ConclusionWith this preliminary screening, we offer a scientific basis for the immunomodulatory properties of the two Nepalese medicinal plants Bassia longifolia and Gmelina arborea. However, further detailed studies regarding the responsible compounds are necessary.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Integrated metallomic and metabolomic profiling of plasma and tissues provides deep insights into the protective effect of raw and salt-processed Achyranthes bidentata Blume extract in ovariectomia rats
ConclusionOur findings indicate that raw and salt-processed AB has positive effects on osteoporosis rats. Meanwhile, metabolomic and metallomic method coupled with metabolites enrichment analysis and pattern recognition serves as a useful tool for revealing the action mechanism of traditional Chinese medicine.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Emex spinosa (L.) Campd. ethyl acetate fractions effects on inflammation and oxidative stress markers in carrageenan induced paw oedema in mice
In this study, the effects of E. spinosa (L.) Campd. against acute inflammation, pain and oxidative damage were evaluated.Materials and methodsTotal phenols and flavonoids were evaluated. Anti-inflammatory and analgesic activities the E. spinosa ethyl acetate fractions of the aerial (Es EtOAc-AP) and underground (Es EtOAc-R) parts were assessed on carrageenan-induced paw oedema (100 mg/kg BW) and acetic acid-induced writhing response (50, 100 and 150 mg/kg BW), respectively. The E. spinosa fractions effects on oxidative stress markers and inflammatory parameters were determined. Gas chromatography-mass spectrometry (GC...
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Chemical and in vitro toxicity analysis of a supercritical fluid extract of Kava kava (Piper methysticum)
ConclusionsKAVOA™, a supercritical carbon dioxide extract of kava displays a similar kavalactone profile to a noble variety of kava. In relation to total kavalactone content, KAVOA™ also has a lower content of the cytotoxic compound FKB. Aqueous extractions of KAVOA™ and noble kava root had no significant negative impact on cell viability and toxicity on HepG2 cells when compared to vehicle controlled treated cells. Results indicate KAVOA™ demonstrates a similar in vitro safety profile to that of noble kava root when experiments are normalized to kavalactone content.Graphical abstract (Source: Journ...
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Aleurites moluccanus and its main active constituent, the flavonoid 2″-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis
ConclusionThese results together with the literature data reinforce the anti-hypersensitivity and anti-inflammatory activity of A. moluccanus extract. Part of the observed effects is due to the presence of the compound 2″-O-rhamnosylswertisin. The fact that the extract acted as a disease modifier point this herbal product as a promisor and safe tool to treat RA and other associated chronic diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum extracts against Pseudomonas aeruginosa
ConclusionsThis study shows that HP plant is capable for blocking of las and rhl QS systems of P. aeruginosa. However, it was observed that ethanol, methanol and acetone extract of the plant samples did not show anti-biofilm activity against P. aeruginosa. This led us to thinking that biofilm formation was caused via another pathway such as IQS or PQS. Further studies with isolated active compounds of HP might give a better understanding of the effects on biofilm formation of P. aeruginosa.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 20, 2019 Category: Drugs & Pharmacology Source Type: research

Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters
ConclusionScientific evidence supports the use of mucuna and ashwagandha as phytotherapics for improving serum T concentrations and semen parameters. Despite inconclusive evidence for use of tribulus as a T booster, it may provide advantageous effects on sperm parameters in men with idiopathic infertility. Nutraceutical strategies and some phytotherapics may also be effective to promote prostate health. Popular foodstuffs (onion, garlic, and tomato), nutraceutical agents (pollen extract and beta-sitosterols), and herbal medicines (Pygeum africanum and Urtica dioica) are rational approaches.Graphical abstract (Source: Journ...
Source: Journal of Ethnopharmacology - February 19, 2019 Category: Drugs & Pharmacology Source Type: research

Exploring on the bioactive markers of Codonopsis Radix by correlation analysis between chemical constituents and pharmacological effects
ConclusionThis study illustrated the underlying correlations between chemical constituents and pharmacological effects, explored the pharmacological material basis, and could lay a foundation for the improvement of quality standard of Codonopsis Radix.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 16, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill
ConclusionThe potential pathways and targets that involved in glycolysis to excert the anti-CRC effects of main compounds in triterpenoids of Rhus chinensis Mill. were predicted by network pharmacology methods. Our findings thus provided rational evidence that inhibition of the ASIC2-induced calcineurin/NFAT pathway by triterpenoids in Rhus chinensis Mill. profoundly suppressed cell growth and invasion in CRC, which target alternative glycolysis in colorectal tumor cells, may be a useful adjuvant therapy in the treatment of colorectal cancer.Graphical abstractInhibitory ASIC2-mediated calcineurin/NFAT against colorectal ca...
Source: Journal of Ethnopharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research

Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating
ConclusionsThe present study demonstrates that R. rosea extract robustly reverses prepulse inhibition deficits in rodents. This suggests antipsychotic-like effects of R. rosea extract. Future studies should focus on the pharmacological mechanisms underlying these effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research

Do recent research studies validate the medicinal plants used in British Columbia, Canada for immune-mediated and other problems in pets?
ConclusionThe injuries treated in pets in British Columbia included abscesses, sprains and abrasions. Dogs were also treated with medicinal plants for rheumatoid arthritis, joint pain and articular cartilage injuries. More than 40 plants were used. Anal gland problems were treated with Allium sativum L., Aloe vera L., Calendula officinalis L., Plantago major L., Ulmus fulva Michx., Urtica dioica L. and the lichen Usnea longissima Ach. Antioxidants in plants, such as diarctigenin from Arctium lappa, used in ethnoveterinary medicine for rheumatoid arthritis and joint pain in pets are said to be of use in treating pathologica...
Source: Journal of Ethnopharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research

Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats
ConclusionAETT is safe after therapeutic (200 mg/kg) or acute administration. Higher dose (400 mg/kg) administered for longer period showed signs of liver toxicity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Intravaginal treatment with Marantodes Pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition
ConclusionsIntravaginal MP was able to ameliorate features associated with VA; thus, it has potential to be used as an agent to treat this condition.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel
ConclusionOur study proves that, 11α-O-tigloyl-12β-O-acetyl-tenacigenin B, 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B and 11α-O-2-methylbutanoyl-12β-O-acetyl-tenacigenin B, which are the main constituents of ETA, are active inhibitors of CYP3A4 with potential to increase therapeutic efficacy of anticancer drugs that are substrates of CYP3A4. Tenacigenin B derivatives with C-11 and C-12 ester group substitutions, or at least a large part of them, are active components in ETA and M. tenacissima to enhance in vivo antitumor efficacies of paclitaxel.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 14, 2019 Category: Drugs & Pharmacology Source Type: research

Sida cordifolia accelerates wound healing process delayed by dexamethasone in rats: Effect on ROS and probable mechanism of action
Publication date: Available online 12 February 2019Source: Journal of EthnopharmacologyAuthor(s): Shweta Kumar, Lakshmi PK, Chandan Sahi, Rajesh Singh PawarGraphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Stem extract of Tabebuia chrysantha induces apoptosis by targeting sEGFR in Ehrlich Ascites Carcinoma
Publication date: Available online 12 February 2019Source: Journal of EthnopharmacologyAuthor(s): Siva Prasad Panda, Uttam Prasad Panigrahy, Subhranshu Panda, Bikash R JenaAbstractEthnopharmacological relevanceThe plant Tabebuia chrysantha (Jaq.) Nicholson (Bignoniaceae) is commonly known as “Golden Goddess” in the Southern part of India and “Golden Trumpet Tree “ in Central America. Stems of this plant have been traditionally used for antioxidant, anti-inflammatory, antimicrobial and anticancer actions.Aim of the studyTo evaluate the antitumor activity of methanol extract of Tabebuia chrysantha ste...
Source: Journal of Ethnopharmacology - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Aleurites moluccanus and its main active constituent, the flavonoid 2’’-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis
ConclusionThese results together with the literature data reinforce the anti-hypersensitivity and anti-inflammatory activity of A. moluccanus extract. Part of the observed effects is due to the presence of the compound 2”-O-rhamnosylswertisin. The fact that the extract acted as a disease modifier point this herbal product as a promisor and safe tool to treat RA and other associated chronic diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review
ConclusionsThis review suggests that medicinal plants possess varied therapeutic dynamics against hypertension and diabetes that could be exploited for the discovery of therapeutic preparation(s) or agent(s) for treating the two diseases. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne
Publication date: Available online 13 February 2019Source: Journal of EthnopharmacologyAuthor(s): Umme Habiba Hassan, Alamgeer, Muhammad Shahzad, Arham Shabbir, Shah Jahan, Muhammad Saleem, Ishfaq Ali Bukhari, Asad Mohammed AssiriAbstractEthnopharmacological relevanceRibes alpestre Decne has been commonly used in the treatment of joint complaints.Aim of studyThe present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.Material and MethodsComplete Freunds adjuvant induced arthritis in Sprague Dawley rats was used...
Source: Journal of Ethnopharmacology - February 13, 2019 Category: Drugs & Pharmacology Source Type: research

Ovicidal and larvicidal effects of extracts from leaves of Andrographis paniculata (Burm. f.) Wall.ex Nees against field isolates of human hookworm (Ancylostoma duodenale)
ConclusionAndrographolide is one of the main phytochemical responsible for significant ovicidal and larvicidal activity against field isolates of A.duodenale from human infections and can be developed as a potential therapeutic choice.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum L. extracts against Pseudomonas aeruginosa
ConclusionsThis study shows that HP plant is capable for blocking of las and rhl QS systems of P. aeruginosa. However, it was observed that ethanol, methanol and acetone extract of the plant samples did not show anti-biofilm activity against P. aeruginosa. This led us to thinking that biofilm formation was caused via another pathway such as IQS or PQS. Further studies with isolated active compounds of HP might give a better understanding of the effects on biofilm formation of P. aeruginosa.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Acid diterpenes from copaiba oleoresin (Copaifera langsdorffii): chemical and plasma stability and intestinal permeability using Caco-2 cells
ConclusionThe oral absorption of both CA and KA is driven by mainly passive permeability, is not limited by p-glycoprotein, but enteric-coated dosage forms should be used to avoid chemical instability in the gastric pH.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark
Publication date: Available online 11 February 2019Source: Journal of EthnopharmacologyAuthor(s): R. Cimanga Kanyanga, S. Nsaka Lumpu, M. Tshodi Ehata, B. Mbamu Maya, C. Kikweta Munduku, F. Makila Bool-Miting, Paul Cos, Louis Maes, Arnold J. Vlietinck, Vassiliki Exarchou, Emmy Tuenter, Luc PietersAbstractEthnopharmacological relevanceAn aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.Materials and methodsExtracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity agai...
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?
Publication date: Available online 11 February 2019Source: Journal of EthnopharmacologyAuthor(s): Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Vânia Vasti Alfieri Nunes, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina dos Santos, Clélia Akiko Hiruma-LimaABSTRACTEthnopharmacological relevanceEugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as “pedra-ume-caá,” is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotecti...
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-proliferative and anti-migratory effects of Scutellaria strigillosa Hemsley extracts against vascular smooth muscle cells
ConclusionsSSHE significantly inhibited the PDGF-BB-induced VSMC proliferation, migration, and neointimal hyperplasia of carotid artery caused by ligation. Upregulation of SM22α expression, inhibition of ROS generation and ERK phosphorylation were, at least, partly responsible for the effects of SSHE on VSMCs.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 12, 2019 Category: Drugs & Pharmacology Source Type: research

Alkamides from Tropaeolum tuberosum inhibit inflammatory response induced by TNF–α and NF–κB
ConclusionsWe identified bioactive compounds from purple and black Tropaeolum tuberosum responsible for their anti–inflammatory activity: N–oleoyldopamine (1) and N–(2–Hydroxyethyl)–7Z,10Z,13Z,16Z–docosatetraenamide (2). This is the first report which isolates these compounds from T. tuberosum and describes their anti–inflammatory activities.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 11, 2019 Category: Drugs & Pharmacology Source Type: research

The scolicidal activity of the essential oil obtained from the needles of Pinus nigra Arn. subsp. pallasiana (Lamb.) Holmboe on hydatid cyst
ConclusionsThe essential oil of P. nigra subsp. pallasiana needles showed scolicidal activity and it could be a new scolicidal agent for using in hydatid cyst treatment.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 11, 2019 Category: Drugs & Pharmacology Source Type: research

Arbutus unedo L., (Ericaceae) inhibits intestinal glucose absorption and improves glucose tolerance in rodents
ConclusionsArbutus unedo L. roots bark aqueous extract directly inhibited the electrogenic intestinal absorption of glucose in vitro. In addition it improved oral glucose tolerance and lowered body weight in rats after chronic oral administration in vivo. These results add a scientific support to the ethnopharmacological relevance use of Arbutus unedo L. roots bark to treat diabetes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 9, 2019 Category: Drugs & Pharmacology Source Type: research

Total flavonoid aglycones extract in Radix Scutellariae induces cross-regulation between autophagy and apoptosis in pancreatic cancer cells
ConclusionTFAE have anti-tumor activity against pancreatic cancer and can induce apoptosis and autophagy through PI3K/Akt/mTOR signal pathway. TFAE might be a potential anticancer drug to be further developed for human pancreatic cancer therapy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

Mutagenicity and genotoxicity effects of Verbena officinalis leaves extract in Sprague-Dawley Rats
ConclusionAqueous extract of V. officinalis has mutagenic effect against TA98 and TA100 strains as demonstrated by Ames test, however, there is no in vivo clastogenic and myelotoxic effect on bone marrow micronucleus of rats indicating that the benefits of using V. officinalis in traditional practice should outweigh risks.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnobotany of medicinal plants used by the Zeliangrong ethnic group of Manipur, northeast India
ConclusionThe medicinal plants with higher use reports can be evaluated for validation pharmacological activities and their toxicity. The Indigenous Knowledge System of Zeliangrong community for herbal remedies may be of immense value in pharmacological experimentation particularly for the uses like malaria, health tonic, cancer, jaundice, hypertension and diabetes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

Antiplasmodial potential and GC-MS fingerprint of endophytic fungal extracts derived from Cameroonian Annona muricata
This study aimed to explore the endophyic fungi associated with some parts of this plant for their ability to produce antiplasmodial metabolites.Materials and MethodsOne hundred and fifty-two endophytic fungi isolated from twelve different organs of A. muricata were cultured and the ethyl acetate extracts of conditioned media screened for antiplasmodial activity using the 96-well microtiter plate format SYBR green florescence assay against Chloroquine-sensitive Pf3D7 and Chloroquine-resistant PfINDO/PfDd2 strains of Plasmodium falciparum.ResultsTwenty-seven (17.76%) of fungi tested were found to completely inhibit the grow...
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

The antifungal and Cryptococcus neoformans virulence attenuating activity of Pelargonium sidoides extracts
ConclusionsOur results provide support to the exploration of medicinal plants as sources of alternative antifungal therapies and the potential use of multicomponent inhibition and or virulence attenuation for next-generation treatment strategies. Our data also provide relevant information that may support the further use of P. sidoides in traditional medicines as well as in commercialised phytopharmaceuticals.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

PKA/β2-AR-Gs/Gi signaling pathway is associated with anti-inflammatory and pro-apoptotic effects of Fuzi and Banxia combination on rats subjected to pressure overload
ConclusionThus, combination of Fuzi and Banxia elicited concurrent protective and toxic effects in PO induced HF. The protective effect appeared to predominate and was associated with suppression of PKA/β2-AR-Gs signaling pathway. Unlike the eighteen antagonisms theory where Fuzi and Banxia combination was considered incompatible, in the present study, this herb pairs appeared to be benefit, and probably had potential therapeutic prospect in treating HFpEF and diseases associated with inflammation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

Traditional Tibetan medicine Anzhijinhua San attenuates Ovalbumin-induced diarrhea by regulating serotonin signaling system in mice
Publication date: Available online 6 February 2019Source: Journal of EthnopharmacologyAuthor(s): Zhenjiang Xia, Yifan Zhang, Cen Li, Yan Xu, Jinjin Dong, Lulu Wang, Qiangqiang He, Xiaoyan Zou, Huali Wu, Jichun Han, Minxuan Cai, Yuzhi Du, Lixin Wei, Jing ShangAbstractEthnopharmacological relevanceTibetan medicine has a history of 3800 years. Anzhijinhua San (AZJHS) which is a traditional Tibetan medicine was effective in the treatment of indigestion, anorexia and cold diarrhea etc. However, the effects of AZJHS on allergic diarrhea have not been reported.Aim of the studyThe aim of present study is to elucidate the effect of...
Source: Journal of Ethnopharmacology - February 7, 2019 Category: Drugs & Pharmacology Source Type: research

Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism
ConclusionFG affected the normal functions of GI via the regulating a variety of metabolic pathways to an abnormal state, and our results provided a research paradigm for the GI-injury of the relative bitter and cold traditional Chinese medicines.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 6, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal plants used for contraception in South Africa: A review
ConclusionsSome of the plants used for contraception in South Africa are toxic to both animals and humans. Research is needed focusing on medicinal plants used by men for contraception and by women for postcoital contraception in South Africa. Traditional healers must be included when drafting contraception policies and interventions. Medicinal plants such as B. latifolia and P. mixta demonstrated that medicinal plants used for contraception in South Africa are potential sources for the discovery and development of safe male and female hormonal contraceptives.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

Genomic and GeneChip Expression Profiling Reveals the Inhibitory Effects of Amorphophalli Rhizoma in TNBC cells
ConclusionsThe inhibitory effects of Amorphophalli Rhizoma in TNBC cells likely occur through regulation of the spindle checkpoint, chromosomal and centrosomal instability, and cell membrane stability.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

The Effect of Jianpi Yangzheng Xiaozheng Decoction and its Components on Gastric Cancer
ConclusionsOur results demonstrate that both JPYZXZ and its components prevent the progress of gastric cancer. JPYZXZ inhibits the gastric cancer EMT more effectively than JPYZ and XZSJ, but JPYZ primarily works to regulate the phenotypic change in macrophages from M2 to M1.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats
ConclusionThese results for the first time demonstrated that SBT exhibited protective effects on CS-induced airway inflammation and MUC5AC hypersecretion, which might be related to the downregulation of the IL-13/STAT6 signaling pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

ANTIDIABETIC EFFECTS OF Olea europaea L. LEAVES IN DIABETIC RATS INDUCED BY HIGH-FAT DIET AND LOW-DOSE STREPTOZOTOCIN
ConclusionsThe results indicate a potential anti-diabetic activity of olive leaves, however more studies are needed to validate clinical effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 3, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: 6 April 2019Source: Journal of Ethnopharmacology, Volume 233Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 3, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats
ConclusionAmong the four studied TCMs, it was demonstrated that co-administration of Gegen and Danggui could lead to altered pharmacokinetics of DAPT with significant inhibition on rCyp2c11 and carboxylesterase activities. Although Gegen, Danggui and Chuanxiong might potentially offset the anticoagulant activity of DAPT, the overall pharmacodynamics outcome was not considered to be harmful due to lack of risk in bleeding, which warrant further verification for its clinical impact.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research

Suppression of Src and Syk in the NF-κB signaling pathway by Olea europaea methanol extract is leading to its anti-inflammatory effects
ConclusionThese results suggest that Oe-ME exerts its anti-inflammatory effects by targeting Src and Syk in the NF-κB signaling pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research

Chemical and in vitro Toxicity Analysis of a Supercritical Fluid Extraction of Kava kava (Piper methysticum)
ConclusionsKAVOA™, a supercritical carbon dioxide extraction of kava displays a similar kavalactone profile to a noble variety of kava. In relation to total kavalactone content, KAVOA™ also has a lower content of the cytotoxic compound FKB. Aqueous extractions of KAVOA™ and noble kava root had no significant negative impact on cell viability and toxicity on HepG2 cells when compared to vehicle controlled treated cells. Results indicate KAVOA™ demonstrates a similar in vitro safety profile to that of noble kava root when experiments are normalized to kavalactone content.Graphical abstract (Source: Jo...
Source: Journal of Ethnopharmacology - January 31, 2019 Category: Drugs & Pharmacology Source Type: research

Chinese Skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats
ConclusionsTaken together, we propose that SRE suppresses abnormal androgen events in prostate tissue and inhibits the development of BPH by targeting inflammation- and apoptosis-related markers. These finding strengthens that SRE could be used as plant-based 5α-reductase inhibitory alternative.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 30, 2019 Category: Drugs & Pharmacology Source Type: research

Brain metabonomics study of the antidepressant-like effect of Xiaoyaosan on the CUMS-depression rats by 1H NMR analysis
ConclusionsIt is the first report to investigate the antidepressant-like effects and underlying mechanisms of XYS from the perspective of brain metabolites. In a broad sense, this study brings novel and valuable insights to evaluate the efficacy of traditional Chinese medicine (TCM), to interpret mechanisms, and to provide the theoretical basis for further research on therapeutic mechanisms in clinical practice.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 30, 2019 Category: Drugs & Pharmacology Source Type: research

Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves)
In this study, an Eriobotrya japonica (loquat leaves) extract (triterpenoid composition of loquat leaves, TCLL) with enriched PTs such as UA was prepared. The study aims to compare the HNE inhibitory (HNEI) effect in vitro and the therapeutic effect on acute lung injury (ALI) in vivo between TCLL and UA.Materials and methodsAn HNEI activity bioassay was performed with Sivelestat sodium hydrate as a positive control. A lipopolysaccharide (LPS)-induced lung inflammatory model was established to evaluate TCLL's therapeutic effect on ALI in vivo. The absorption of UA in TCLL and in UA alone was determined using a Caco-2 cell u...
Source: Journal of Ethnopharmacology - January 29, 2019 Category: Drugs & Pharmacology Source Type: research

Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia
ConclusionOur study found that a standardized extract of an ethanolic extract and its butanolic fraction from the stem of Cassia occidentalis has osteogenic as well as anti-resorptive effects, resulting in the protection against glucocorticoid-induced bone loss. Our results contribute towards validation of the traditional use of Cassia occidentalis in fracture healing and also suggest its beneficial use in GIO for which clinical trials are warranted.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 29, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of Polyherbal Ayurvedic Formulation ‘Peedantak Vati’ for Anti-inflammatory and Analgesic Properties
Publication date: Available online 28 January 2019Source: Journal of EthnopharmacologyAuthor(s): Acharya Balkrishna, Ravikant Ranjan, Sachin S. Sakat, Vinay K. Sharma, Ravikant Shukla, Khemraj Joshi, Raviraj Devkar, Niti Sharma, Sonia Saklani, Prateek Pathak, Pratima Kumari, Veena R. AgarwalAbstractEthnopharmacological relevancePeedantak Vati (PV) is a polyherbal ayurvedic formulation, which is regularly prescribed by the ayurvedic practitioner for the inflammatory disorders and joints pain in India. It is composed of 23 different herbs and minerals, described in ayurvedic text for their anti-inflammatory and analgesic pro...
Source: Journal of Ethnopharmacology - January 29, 2019 Category: Drugs & Pharmacology Source Type: research