Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice
ConclusionThese data demonstrate that RDP ameliorates renal fibrosis through TGF-β/Smad and MAPK pathways in a UUO mouse model.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes
Publication date: Available online 18 October 2018Source: Journal of EthnopharmacologyAuthor(s): Gabriel O. Anyanwu, Jamshed Iqbal, Shafi U. Khan, Sumera Zaib, Khalid Rauf, Chukwu E. Onyeneke, Opeolu O. Ojo, Nisar-ur-RahmanAbstractEthnopharmacological relevanceAnthocleista vogelii Planch is a medicinal plant traditionally used in West Africa for the management and treatment of diabetes mellitus.Aim of the studyTo determine the antidiabetic activities of chloroform fraction (CF) of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes.Materials and MethodsInhibitory activities of CF a...
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Reversing Effects of Ginsenosides on LPS-induced Hepatic CYP3A11/3A4 Dysfunction Through the Pregnane X Receptor
ConclusionGinsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Memory enhancing, anticholinesterase and antimicrobial activities of β-phenylnitroethane and essential oil of Dennettia tripetala Baker f
ConclusionThe most abundant component - β-phenylnitroethane of D. tripetala was totally responsible for its memory enhancing properties but could not solely account for its antimicrobial activity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

An in vitro validation of the therapeutic effects of Tougu Xiaotong capsule on tunicamycin-treated chondrocytes
ConclusionsThe present study provides evidence of the therapeutic effects of TXC at the cell level and describes a cellular model for establishing the mechanisms of the effects of TXC used in the treatment of OA.Graphical abstractER stress pathway may play a role in the mechanisms of TXC. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Male sexual enhancers from the Peruvian Amazon
ConclusionThe traditional preparations used to improve sexual performance in the Peruvian Amazon showed activity as phosphodiesterase-5 inhibitors. The most active ingredient of the traditional preparations was C. angustifolia, with some contribution from T. panurensis. These results encourage additional studies, including animal models to confirm the male enhancer effect of the preparations.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Airway smooth muscle relaxant activity of Cordia dodecandra A. DC. mainly by cAMP increase and calcium channel blockade
ConclusionsResults suggest that DECd-b induces relaxation mainly by cAMP increase and Ca2+ channel blockade. The chromatographic profiles and UV spectrum of DECd-b and HECd-l suggest the presence of molecules with structure of meroterpenoid naphthoquinones. This work report scientific evidence of C. dodecandra medicinal specie, which contributes to the pharmacological and phytochemical background of C. dodecandra providing an added value to the traditional use of this specie.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Linking resource supplies and price drivers: lessons from Traditional Chinese Medicine (TCM) price volatility and change, 2002 − 2017
ConclusionsPrice fluctuations in the four TCM species we examined are influenced by many factors and not just resource scarcity. And the situation is more complex than the trajectory based on Homma's (1992) model, where he predicted that higher prices would result in a shift to cultivation, thus replacing wild harvest. In case of both O. sinensis and P. polyphylla, Homma (1992, 1996) was right in terms of scarcity and high prices stimulating a major investment in cultivation (P. polyphylla) and artificial production (O. sinensis). But in both cases, intensive production through cultivation or artificial propagation do not ...
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Incompatibility assessment of Genkwa Flos and Glycyrrhizae Radix et Rhizoma with biochemical, histopathological and metabonomic approach
ConclusionThe toxicities of YH and YH-GC combination above the Chinese Pharmacopoeia dose were obvious but different. Metabonomics combined with biochemical and histopathological methods can be applied to elucidate the toxicity mechanism of the YH-GC combination that caused liver, kidney and reproductive injuries in rats.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Nasturtium officinale R. Br. effectively reduces the skin inflammation induced by croton oil via glucocorticoid receptor-dependent and NF-κB pathways without causing toxicological effects in mice
ConclusionOur results suggest the N.officinale use in the cutaneous inflammatory process treatment and demonstrate the NoE potential to develop a promising topical anti-inflammatory agent to treat inflammatory disorders.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Diarylheptanoid, a constituent isolated from methanol extract of Alpinia officinarum attenuates TNF-α level in Freund's complete adjuvant-induced arthritis in rats
Publication date: Available online 15 October 2018Source: Journal of EthnopharmacologyAuthor(s): Varsha S. Honmore, Amit Kandhare, Parag P. Kadam, Vijay M. Khedkar, Arun D. Natu, Supada R. Rojatkar, Subhash L. BodhankarAbstractEthnopharmacological relevanceRheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects the worldwide population. Alpinia officinarum Hance (Zingiberaceae), rhizomes are widely used ethnobotanically as an anti-inflammatory, analgesic, and antioxidant agent in traditional medicine.AimTo investigate the efficacy and possible mechanism of isolated phytoconstituent fr...
Source: Journal of Ethnopharmacology - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

An ethnobotanical survey and antifungal activity of Piper guineense used for the treatment of fungal infections in West-African traditional medicine
ConclusionP. guineense fruit and leaf extracts, as well as their piperamide alkaloid constituents piperine and piperlongumine, have interesting antifungal properties and could have potential as new antifungal scaffolds. Our results warrant further in-depth investigations to isolate and characterize piperamide alkaloids and other compounds responsible for the antifungal activity in the extracts.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Efficient identification of Acetylcholinesterase and Hyaluronidase inhibitors from Paeonia parnassica extracts through a HeteroCovariance Approach
ConclusionsThe results of this study contributed to the verification of the ancient text Theriaca regarding the use of Paeonia parnassica to treat the snake bite symptoms. Furthermore, the ingredients of the Paeonia parnassica extracts, which were responsible for their anticholinesterase and anti-hyaluronidase activities, were determined applying a HetCA methodology before their isolation. Therefore, the current work provides clear evidence that HetCA could consist an efficient tool for the exploitation of traditional medicine information in order to discover bioactive natural compounds and develop new pharmacotherapies wh...
Source: Journal of Ethnopharmacology - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma
ConclusionZBSO possessed anticancer activities that were selectively effective to A375 cells. This study support the hypothesis that ZBSO is a capable candidate for anti-melanoma agent, and provide new insights for future work on investigating the utilization of ZBSO in malignant melanoma treatment.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 15, 2018 Category: Drugs & Pharmacology Source Type: research

Introduction to the special issue: Saving plants, saving lives: trade, sustainable harvest and conservation of traditional medicinals in Asia
Publication date: Available online 13 October 2018Source: Journal of EthnopharmacologyAuthor(s): A.B. Cunningham, J.A. Brinckmann, X. Yang, X, J. HeAbstractThis “geographic and thematic” issue of the Journal of Ethnopharmacology focuses on the traditional medicines in trade in Asia on the 30th anniversary of the 1988 Chiang-Mai Declaration, an output of an historic meeting organized by WHO, IUCN and WWF. The emphasis on the Asian countries that represent the highest volume and value of medicinal plants trade in the world is deliberate. Not only because of the scale and speed of changes in traditional medicines ...
Source: Journal of Ethnopharmacology - October 14, 2018 Category: Drugs & Pharmacology Source Type: research

Celosia argentea L. (Amaranthaceae) a vasodilator species from the Brazilian Cerrado – An ethnopharmacological report
ConclusionThis study has brought new scientific evidence of preclinical efficacy of C. argentea as a hypotensive agent in normotensive rats. Apparently, these effects are involved with the activation of the voltage-sensitive K+ channels contributing to the reduction of peripheral vascular resistance and cardiac output.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

The Medicinal Uses, Toxicities and Anti-inflammatory Activity of Polyalthia Species (Annonaceae)
ConclusionsNumerous pharmacological studies have supported the use of Polyalthia species against pain, rheumatic fever, haemorrhages and inflammation in traditional medicine. Flavonoids, diterpenoids, sterols and styrylpyrones from genus Polyalthia are the most significant class of compounds with potent anti-inflammatory activity. Secondary metabolites from these classes should be brought into further research to fill the gaps of knowledge in pharmacokinetics, pharmacodynamics, bioavailability, and toxicity in order to convert the pre-clinical results into clinical data for further investigation.Graphical Abstract (Source:...
Source: Journal of Ethnopharmacology - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Toxicological evaluation of a standardized hydroethanolic extract from leaves of Plantago australis and its major compound, verbascoside
ConclusionThe HPLC method to quantify verbascoside was validated, and the extraction of verbascoside from P. australis leaves through ultrasound method was optimized, yielding an extract with 6% verbascoside. Our results suggest the toxicological safety of PAHE and verbascoside, corroborating the use of P. australis in folk medicine, and also indicate verbascoside as a potential ingredient in topical formulations.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 12, 2018 Category: Drugs & Pharmacology Source Type: research

Berberis orthobotrys – A promising herbal anti-tumorigenic candidate for the treatment of pediatric alveolar rhabdomyosarcoma
ConclusionsThe study provides the first evidence, that BORM treatment is effective against RMA cells with low side effects on healthy cells.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 12, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity of Luffa cylindrica (L.) M.Roem. extract against circulating cancer stem cells in hepatocellular carcinoma
ConclusionHot water extract of Luffa cylindrica whole plant could decrease the ratio of cancer stem cells in blood of HCC patients and may be used to minimize recurrence and metastasis in hepatocellular carcinoma patients.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 12, 2018 Category: Drugs & Pharmacology Source Type: research

Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology
ConclusionsIn conclusion, DS has an anti-atherosclerotic ability to lower lipid concentrations and to protect endothelial function, and it also has anti-inflammatory activity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 10, 2018 Category: Drugs & Pharmacology Source Type: research

The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers
ConclusionsCompatibility of SND altered the intestinal absorption of toxic MDAs and hypaconitine from processed aconite root. In SND, dried ginger rather than honey-processed liquorice played the role of detoxification of these toxic compounds in the intestinal absorption. The intestinal detoxification of SND was significantly and strongly correlative with metabolism of dried ginger and honey-processed liquorice by intestinal bacteria, simultaneously.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 10, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy of Aeschynomene indica L. leaves for wound healing and isolation of active constituent
ConclusionLeaves of AIL and its active constituent (Sub-Fr0.2) effectively promoted wound healing and reduced scar formation, this efficacy might be exerted by accelerating macrophages phenotypes transition and inhibiting TGF-β1 and α-SMA expression.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Nigella sativa L. seed regulated eNOS, VCAM-1 and LOX-1 genes expression and improved vasoreactivity in aorta of diabetic rat
ConclusionsThe results of this study showed that N. sativa seed more likely, has antidiabetic and antihyperlipidemic properties and improved vasoreactivity, endothelial dysfunction, and vascular inflammation in diabetic rats' aorta.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Traditional Chinese medicine is associated with a decreased risk of heart failure in breast cancer patients receiving doxorubicin treatment
Publication date: Available online 25 September 2018Source: Journal of EthnopharmacologyAuthor(s): Ching-Hui Huang, Hui-Ping Chang, Shou-Yi Su, Wen-Kang Chen, Yu-Jun Chang, Yang-Cheng Lee, Yu-Jui KuoAbstractEthnopharmacological relevanceCardiovascular disease is the main concern of breast cancer survivors who received doxorubicin treatment. Traditional Chinese medicine (TCM) provides as a complementary therapy to patients with breast cancer and is an important component of health care in Taiwan. However, the TCM utilization patterns and it's efficacy in breast cancer patients is unknown.Materials and methodsFrom a sample o...
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

An assessment of the Chinese medicinal Dendrobium industry: supply, demand and sustainability
ConclusionsThis review summarizes the species and cultivation history of medicinal herbs in the Dendrobium. The review can help inform future scientific research towards the TCM in Dendrobium, including mycorrhizal technology and microorganism fertilizer, pharmacological studies, the directed cultivation of varieties and diversified product. It is suggested that Dendrobium cultivation has a great potential to link the commercial TCM industry together with initiatives of biodiversity conservation. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Xinjiang herbal tea exerts immunomodulatory activity via TLR2/4-mediated MAPK signaling pathways in RAW264.7 cells and prevents cyclophosphamide-induced immunosuppression in mice
ConclusionThese results indicated that XMT-WE at 50 µg/ml exerts immunomodulatory activity via TLR2/4-mediated MAPK signaling pathways in RAW 264.7 cells. Furthermore, in vivo experiments revealed that XMT-WE at the dose of 50 and 100 mg/kg strongly stimulated inflammatory cytokines.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats
ConclusionThis integrated metabolomics approach confirmed the validity of the traditional use of HCW in the treatment of liber fibrosis, providing new insights into the underlying mechanisms.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Genus Vanda: A review on traditional uses, bioactive chemical constituents and pharmacological activities
ConclusionVanda spp. are of much significance as ornamental flowers, but also used widely in traditional medicines and have potential for their diverse pharmacological activities. However, many members of the genus Vanda need further detailed studies regarding chemical constituents and mechanism-based pharmacological activities. Similarly, further studies should also focus on the conservation, cultivation and sustainable utilization of these species.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC-MS for promotion of blood circulation and relief of pain
ConclusionHSYJ possessed the effect of promoting blood circulation and relieving pain. Curcumins and their derivatives were the major constituents and might be the main bioactive ingredients for the promotion of blood circulation and relief of pain. The study provided evidence and formed a basis for the establishment of HSYJ comprehensive quality evaluation system related to traditional efficacy. It is beneficial to the quality control of HSYJ and its proprietary Chinese medicine.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: Refocusing into multi-component potentials
ConclusionsThe benefits achieved from the seven tested plant species as traditional ethnomedicinal and ethnoveterinary therapies or in zoopharmacognosy against infections and conditions of animals in the wild are strongly supported by results of this study. The synergy of plant extracts, so achieved by concerted actions of the ligands, produces adequate perturbation of targets in the four parasite genera, resulting in the strong potencies exhibited by low IC50values. The total inhibitory effect, achieved as a sum of perturbations contributed by each participating compound in the extract, minimises toxic effects of the comp...
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-melanogenic effects of oyster hydrolysate in UVB-irradiated C57BL/6J mice and B16F10 melanoma cells via downregulation of cAMP signaling pathway
ConclusionsThese results show that OH inhibits melanin synthesis in B16F10 cells via downregulation of cAMP signaling pathway and in UVB-irradiated mice, by decreasing the number of active melanocytes and melanin granules.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Transcriptomics and Metabonomics of the Anti-Aging Properties of Total Flavones of Epimedium in Relation to Lipid Metabolism
ConclusionsThis study demonstrates that the role played by TFE in the lipid metabolism of aging rats is multifaceted and multi-layered.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Are polyphenol antioxidants at the root of medicinal plant anti-cancer success?
ConclusionsFrom the literature reviewed, most plant products with consistently reported anti-cancer efficacy contains high levels of polyphenols or other potent antioxidants and their mechanisms of action correlate to that reported for isolated antioxidants in the context of cancer. This suggests that natural products may indeed become the panacea against this chronic disease – either as therapeutic medicine strategy or to serve as templates for the design of novel synthetic drugs. The recommendation is made that antioxidant activity of plant actives and especially polyphenols, should be the focus of anti-cancer drug...
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

The flavonoid acetylpectolinarin counteracts the effects of low ethanol on spontaneous network activity in hippocampal cultures
ConclusionsOur results suggest that ACP acts by interacting with the SK channel, to block the facilitatory effect of low concentration of ethanol, on network activity in hippocampal cultures.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity of Luffa cylindrica (L.) M.Roem extract against circulating cancer stem cells in hepatocellular carcinoma
ConclusionHot water extract of Luffa cylindrica whole plant could decrease the ratio of cancer stem cells in blood of HCC patients and may be used to minimize recurrence and metastasis in hepatocellular carcinoma patients.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Rosmarinus officinalis Essential oil: A review of its phytochemistry, anti-inflammatory activity, and mechanisms of action involved
ConclusionsCurrent evidence indicates anti-inflammatory activity in EORO, supporting its ethnopharmacological uses in inflammatory-related diseases, and potential future applications. However, although considerable acute inflammatory models were tested, more chronic inflammatory models are needed; clinical studies are still absent, this may be due to the high doses needed for essential oils to exert pharmacological effects, but recent studies show this issue can be bypassed using the oil formulated as nanoemulsions to improve its bioavailability.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: 5 December 2018Source: Journal of Ethnopharmacology, Volume 227Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Buyang huanwu decoction combined with BMSCs transplantation promotes recovery after spinal cord injury by rescuing axotomized red nucleus neurons
ConclusionsBYHWD combined with BMSCs transplantation had synergistic effect on neuroprotection of red nucleus neurons after SCI; the mechanism may be related to up-regulating cAMP level, activating the cAMP/CREB/RhoA signaling pathway, and promoting expression of NGF.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Celosia argentea L. (Amaranthaceae) a vasodilator species from the Brazilian Cerrado - An ethnopharmacological report
ConclusionThis study has brought new scientific evidence of preclinical efficacy of C. argentea as a hypotensive agent in normotensive rats. Apparently, these effects are involved with the activation of the voltage-sensitive K+ channels contributing to the reduction of peripheral vascular resistance and cardiac output.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 22, 2018 Category: Drugs & Pharmacology Source Type: research

Origanum majorana L. extract exhibit positive cooperative effects on the main mechanisms involved in acute infectious diarrhea
Conclusionthe present results indicate that aqueous extract of Origanum majorana L. exhibit positive cooperative effects on the main mechanisms that are involved in acute infectious diarrhea.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 22, 2018 Category: Drugs & Pharmacology Source Type: research

Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis
ConclusionsThese results suggest that AR and FMT act as anti-pollution agents and alleviate PM induced skin barrier defects through regulation of apoptosis and proliferation in keratinocytes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein
ConclusionsOur results proved that HQ and its main bioactive compounds could induce the P-gp and BCRP expression through the activation of the Nrf2-mediated signaling pathway. HQ and these compounds also significantly enhanced the efflux activity of P-gp and BCRP, and the increased intracellular ATP levels were likely involved in the increased P-gp and BCRP function. These results suggested that potentially HDIs likely occurred when HQ was used concomitantly with other drugs that are substrates of P-gp and BCRP.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical efficacy and safety of Aidi injection plus paclitaxel-based chemotherapy for advanced non-small cell lung cancer: A meta-analysis of 31 randomized controlled trials following the PRISMA guidelines
ConclusionsCurrent moderate evidence revealed that Aidi injection plus paclitaxel-based chemotherapy, especially TP can significantly improve the clinical efficacy and QOL for patients with stage III/IV NSCLC. Aidi injection can relieve the risk of hematotoxicity, gastrointestinal toxicity and liver injury in patient with NSCLC receiving paclitaxel-based chemotherapy. The optimal usage may be 50 ml/time and 14 days/2 cycles.Graphical AbstractMain findings: Aidi injection plus paclitaxel-based chemotherapy, especially TP can significantly improve the clinical efficacy and QOL in patients with advanced NSCLC. Aidi injec...
Source: Journal of Ethnopharmacology - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: combined computational predictions and experimental investigations
ConclusionsThe chemical and biological properties of SO, SP and SG were different and distinctive. They might be reasonably applied in clinic for the management of rheumatism/-related diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Nigella sativaL. seed regulated eNOS, VCAM-1 and LOX-1 genes expression and improved vasoreactivity in aorta of diabetic rat
ConclusionsThe results of this study showed that N. sativa seed more likely, has antidiabetic and antihyperlipidemic properties and improved vasoreactivity, endothelial dysfunction, and vascular inflammation in diabetic rats' aorta.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

Achyranthes aspera Linn. Alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats
ConclusionsThese findings suggest that the MeAA possesses potent cerebroprotective action through its antioxidant and anti-inflammatory mechanisms.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

Compatibility and its metabolism by intestinal bacteria altered the transport of toxic diterpenoid alkaloids from processed aconite root (lateral root of Aconitum carmichaelii Debx.) in traditional Chinese formula Si-Ni decoction across Caco-2 monolayers
ConclusionsCompatibility of SND altered the intestinal absorption of toxic MDAs and hypaconitine from processed aconite root. In SND, dried ginger rather than honey-processed liquorice played the role of detoxification of these toxic compounds in the intestinal absorption. The intestinal detoxification of SND was significantly and strongly correlative with metabolism of dried ginger and honey-processed liquorice by intestinal bacteria, simultaneously.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

Fabiana imbricata Ruiz et Pav. (Solanaceae), a review of an important Patagonian medicinal plant
Publication date: Available online 12 September 2018Source: Journal of EthnopharmacologyAuthor(s): Guillermo Schmeda-Hirschmann, Cristina TheodulozAbstractEthnopharmacological relevanceFabiana imbricata (Solanaceae) is a Patagonian medicinal plant with a long tradition of use. The aim of this review is to provide an integrative overview of the traditional uses, chemistry, bioactivity and chemical profiling of the crude drug.Materials and methodsThe information was collected from scientific databases searching with the keywords Fabiana imbricata, Fabiana species, Fabiana (Solanaceae) and includes local literature and books....
Source: Journal of Ethnopharmacology - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological parameters in streptozotocin induced diabetic rats
This study investigated the effects of Parkia biglobosa aqueous seed extract on some biochemical, haematological and histopathological indices in streptozotocin-induced diabetic rats.Materials and MethodsWistar rats of either sex (180–300 g) were fasted overnight and diabetes mellitus induced using streptozotocin 40 mg/kg IP. Diabetes mellitus (fasting blood glucose ≥ 200 mg/dl) was confirmed 48 hours later. The rats were randomly grouped into six groups (n = 5): Group 1 (diabetic untreated control), group 2 (Parkia biglobosa 200 mg/kg), group 3 (Parkia biglobosa 400 mg/kg). group 4 (...
Source: Journal of Ethnopharmacology - September 13, 2018 Category: Drugs & Pharmacology Source Type: research