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Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia
Conclusion Decreasing effect of Dioscin on serum uric acid level and enhancing effect on urate excretion were confirmed in hyperuricemia animal models. Tigogenin, a metabolite of Dioscin, was identified as an active substance with antihyperuricemic activity in vivo, through inhibition of URAT1 and promotion of ABCG2. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Efficacy of Violet oil, a traditional Iranian formula, in patients with chronic insomnia: A randomized, double-blind, placebo-controlled study
Conclusion Considering the effects of natural nasal drug on the improvement of sleep quality in insomniac patients, this study has proposed the use of Violet oil as a natural and herbal drug in a non-oral method without serious side effects for treatment of insomnia. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Assessment of the laxative activity of an ethanolic extract of Bambusa arundinacea (Retz.) Willd. shoot
Conclusions The results of this study provide support for the traditional use of B. arundinacea shoot as a laxative. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 8, 2017 Category: Drugs & Pharmacology Source Type: research

Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat
Conclusions XYS reversed the abnormalities of the tryptophan-kynurenine metabolic pathways in depressed rats and achieved an excellent antidepressant effect. Its direct impact may be observed as changes in biological indicators in rat hippocampus tissue. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 8, 2017 Category: Drugs & Pharmacology Source Type: research

Comparison of the inducible effects of licorice products with or without heat-processing and pre-treatment with honey on granulocyte colony-stimulating factor secretion in cultured enterocytes
Conclusions The enhanced inducible effect of honey-roasted licorice on G-CSF secretion might be attributed to the combined effect of licorice-derived high molecular compounds and heated-honey-derived compounds. The results of this study can scientifically explain the objective of processing via honey-roasting in TCM theory. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 8, 2017 Category: Drugs & Pharmacology Source Type: research

In vitro and in vivo anti-malignant melanoma activity of Alocasia cucullata via modulation of the phosphatase and tensin homolog/phosphoinositide 3-kinase/AKT pathway
In this study, we evaluated the anti-melanoma effect and the underlying mechanism of 50% ethanolic extract of A. cucullata (EAC) in vitro and in vivo. Using MTT, wound healing, and transwell assays, we found that EAC suppressed the proliferation, migration, and invasion of melanoma cells (B16-F10, A375 and A2058) in a dose-dependent manner. We also found that EAC suppresses B16-F10 tumor growth in a xenografted mouse model. Western blot analysis revealed that the expression level of PTEN was up-regulated, and phosphorylation of PI3K and AKT reduced in B16-F10 cells and tumor tissues after EAC treatment. No significant diff...
Source: Journal of Ethnopharmacology - December 6, 2017 Category: Drugs & Pharmacology Source Type: research

Assessment of the anti-snakebite properties of extracts of Aniba fragrans Ducke (Lauraceae) used in folk medicine as complementary treatment in cases of envenomation by Bothrops atrox
Conclusion In addition to being effective in reducing hemorrhage when administered orally, the extracts displayed a high antimicrobial potential against microorganisms involved in secondary infections at the site of the snakebite. Once the extracts have been tested in accordance with the appropriate regulations, this species could potentially be used to produce a phytomedicine for complementary treatment of the secondary infections due to bacteria that aggravate the local signs and symptoms after snakebite envenomation. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Ethnoveterinary botanical survey of medicinal plants in Abergelle, Sekota and Lalibela districts of Amhara region, Northern Ethiopia
Conclusion We found the area has a huge resource of ethnoveterinary medicinal plants. However, overuse and environmental anthropological change resulted in the scarcity of medicinal plants. This condition was complained by healers during the survey. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats
Conclusion These findings suggest that the SSLE formula prevents muscle atrophy through inhibition of the ubiquitin-proteasome system as well as upregulation of myoblast differentiation and muscle protein synthesis in C2C12 cells. Taken together, we conclude that the SSLE formula is invaluable for the development of therapeutic medicines to prevent disuse muscle atrophy and its accompanying muscle weakness. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

The inhibitory effect of Aconiti Sinomontani Radix extracts on the proliferation and migration of human synovial fibroblast cell line SW982
Conclusion The results showed that MQB inhibited proliferation and migration of SW982 cells possibly through suppressing Wnt5a-mediated JNK and NF-κB pathways. These results indicated that MQB might be an active extract of Aconiti Sinomontani Radix for targeting fibroblast-like synoviocytes (FLS) and be potential for RA therapy. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Population change of Trillium govanianum (Melanthiaceae) amid altered indigenous harvesting practices in the Indian Himalayas
Conclusion Gathering of T. govanianum from wild populations is unselective and unmanaged, raising the potential threat of local extinctions. Sustainable utilization and effective conservation is needed to protect the species and maintain community incomes. A status of ‘threatened’ is justified for the species in the Indian Himalayan region, due to its slow life cycle, specific habitat requirement, low population density, and commercial value. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Isolation and pharmacological characterization of a new cytotoxic L-amino acid oxidase from Bungarus multicinctus snake venom
Conclusion This study will facilitate the study on anti-tumor mechanism of snake venom and drug development based on Bungarus multicinctus venom. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Treatment of malaria and related symptoms using traditional herbal medicine in Ethiopia
Conclusions The result of the current study showed that traditional knowledge is still playing an important role in the management of malaria and related symptoms in Ethiopia. Allium sativum L., Carica papaya L., Vernonia amygdalina Del., and Lepidium sativum L. are the most commonly reported species as anti-malarial plants and the traditional claim of some species was supported by known anti-plasmodial activity and bioactivity reports. The finding of this study is important in the rational prioritization of plant species which are potentially used for investigating new compounds, which could be efficacious for malaria tre...
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments
Conclusion These findings provide evidence that sesquiterpene lactones might be potential anti-allergic therapeutics. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Leon,  Christine, Yu-Lin, Lin, Chinese Medicinal Plants, Herbal Drugs and Substitutes, An Identification Guide. Kew Publishing, Royal Botanic Gardens Kew, London, UK. (pp 806, over 3000 colour photographs, 300mm × 250mm. ISBN: 978 1 84246 387 1, e-ISBN: 978 1 84246 630 8 (Hardback) - £110.00.).
Publication date: 1 March 2018 Source:Journal of Ethnopharmacology, Volume 213 Author(s): Anthony Booker (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Determination of the effect of Pinellia ternata (Thunb.) Breit. on nervous system development by proteomics
Conclusion The results suggested that oral administration of BX in mice may cause fetal abnormality of the nervous system. The findings may be helpful to elucidate the underlying mechanisms of BX-induced embryotoxicity. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil
Conclusions Cytotoxic and genotoxic effects were demonstrated in all extracts and fractions used, although only EAF showed mutagenic effects by CBMN, but not by Salmonella/microsome assay. Our results suggest that flavonoids, phenylpropanoids, coumarins, and diterpenes may be responsible for the cytotoxic, genotoxic and mutagenic effects observed. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Acute and sub-acute oral toxicity studies of the aqueous extract from radix, radix with cortex and cortex of Psammosilene tunicoides in mice and rats
Conclusions As shown in the results, Psammosilene tunicoides has a toxic potential in acute and sub-acute oral administrations. However, there is no direct relationship between toxicity and the cortex. Daily oral administration of three different parts from Psammosilene tunicoides (PR, PRC and PC) may cause damages to heart, lung and kidney in rats. Thus these extracts should be used with caution. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Altered TNF- α response by Aconibal® and methotrexate in a lipopolysaccharide-induced setting of inflammatory conditions: Potential on a synergistic combination
Conclusions Our data show for the first time the potential beneficial effects of AMC in RA management. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory, antinociceptive and antioxidant properties of Schinopsis brasiliensis bark
Conclusion HEE and EAF from S. brasiliensis bark show pharmacological interest because they were able to inhibit the peripheral and central transmission of pain. Our data also suggest that the anti-inflammatory activity caused by EAF exposure occurs through the inhibition of the pro-inflammatory cytokine TNF-α, also reducing the spreading of the inflammatory processes by neutralizing reactive oxygen species, which are by-products in the biosynthesis of pain mediators. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Oral chronic toxicity study of geniposide in rats
Conclusion Geniposide affected serum biochemistry, urinalysis, and haematological parameters as well as relative organ weights. The treatment also caused noticeable pathological abnormalities in liver and kidney tissues. Therefore, administration of a high dose of geniposide (100mg/kg) for 26 weeks could induced obvious liver and kidney damage. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination
Conclusion AA provided scientific evidence, substantiating the traditional claims for its use in the treatment of inflammation and inflammation-mediated metabolic disorders, including gout. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Eucalyptus robusta leaves methanolic extract suppresses inflammatory mediators by specifically targeting TLR4/TLR9, MPO, COX2, iNOS and inflammatory cytokines in experimentally-induced endometritis in rats
Conclusions Eucalyptus robusta leaves extract possess promising antibacterial activity and efficacy against experimental endometritis and, therefore, holds promising potential for development of effective formulation for treatment of endometritis in animals. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Dual mechanisms of anti-muscarinic and Ca++ antagonistic activities to validate the folkloric uses of Cyperus niveus Retz. as antispasmodic and antidiarrheal
Conclusion This study shows the presence of antidiarrheal and spasmolytic activities in Cyperus niveus Retz. extract, mediated by dual blocking mechanisms of muscarinic receptors and Ca2+ channels. The results further indicate the presence of anti-emetic activity in Cn. Cr, which may be because of its anti-muscarinic potential. This study provides the scientific bases to the traditional use of Cn. Cr in diarrhea and emesis. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench
Conclusion Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools
Conclusion In conclusion, the results of this study proved that PMEAF is a promising anticancer agent with high cytotoxicity against MDA-MB-231 breast cancer cells and it induced apoptotic cell death mechanism through the regulation of miRNAs. PMEAF might be the best candidate for developing more potent anticancer drugs or chemo preventive supplements. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Can highly cited herbs in ancient Traditional Chinese medicine formulas and modern publications predict therapeutic targets for diabetes mellitus?
Conclusions Our review and the preliminary bioactive study revealed that 10 of the 12 recommended edible TCM herbs had favorable antidiabetic effects, demonstrating that TCM herbs with a high prescription and publication frequency may provide insights into the potential therapeutic targets of diabetes mellitus and may aid in the discovery of effective compounds complementary to currently used medicines. Such a literature and medicine review is a useful method of exploring potential antidiabetic herbs by using the wealth of information in ancient TCM formulas and modern publications. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan
Conclusion The use of CHM as an adjunctive therapy may reduce the mortality hazard ratio of lung cancer patients. The investigation of their comprehensive CHM prescription patterns might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments for lung cancer patients. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Morinda officinalis How. – A comprehensive review of traditional uses, phytochemistry and pharmacology
Conclusion MO has emerged as a good source of traditional medicines. Some uses of this plant in traditional medicines have been validated by pharmacological investigations. However, the molecular mechanism, structure-activity relationship, and potential synergistic and antagonistic effects of its multi-components such as polysaccharides, oligosaccharides, anthraquinones and iridoid glycosides need to be further elucidated, and the structural feature of polysaccharides also need to be further clarified. Sophisticated analytical technologies should be developed to comprehensively evaluate the quality of MO based on HPLC-fing...
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

The beneficial health aspects of sea buckthorn (Elaeagnus rhamnoides (L.) A.Nelson) oil
Conclusion Sea buckthorn is a unique plant. Its beneficial properties against cardiovascular disorders have been attributed to its high UFA content and range of phytosterols, especially beta-sitosterol. However, its different action on the human organism remain unclear, and further well-controlled, high-quality experiments with human subjects are required to determine the prophylactic and therapeutic doses of sea buckthorn oil for use in clinical studies. Additional studies are also needed to understand the action by which the oil exerts its beneficial properties, i.e. its cardioprotective and anti-cancer activity. Graphic...
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc
Conclusions In this paper, we reviewed various studies conducted on C. officinalis, especially in areas of its ethnopharmacological use, as well as on its phytochemistry, pharmacology, and modern analytical methods used. Some of the herb’s ethnomedical indications have been confirmed by the herb’s pharmacological effects, such as its hepatic and renal protection and the antidiabetic effects. In particular, the crude extract and its chemical composition have exerted good therapeutic effect in diabetic treatment. C. officinalis entails additional attention on its pharmacological effects and drug development to ex...
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

The role of endemic plants in Mauritian traditional medicine – Potential therapeutic benefits or placebo effect?
Conclusions With a consumer-driven ‘return to nature’, scientific validation and valorization of the herbal remedies, including efficacy and safety are, therefore, important. This review reports the scarcity of research on validating the efficacy and safety of medicinal endemic plants. This calls for the use of optimised methodologies to investigate the claims of therapeutic effects resulting from the use of these traditional medicines. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Curcuzedoalide contributes to the cytotoxicity of Curcuma zedoaria rhizomes against human gastric cancer AGS cells through induction of apoptosis
Conclusion These data indicate that curcuzedoalide contributed to the cytotoxicity of C. zedoaria by activating the cleavage of caspases and PARP, which are representative markers for apoptosis. Therefore, curcuzedoalide is a positive candidate for the development of novel chemotherapeutics. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 18, 2017 Category: Drugs & Pharmacology Source Type: research

Facilitating effects of Buyang Huanwu decoction on axonal regeneration after peripheral nerve transection
Conclusions Our data suggest that BYHWD treatment may contribute to the timely interaction between regenerating axons and distal Schwann cells in the transected nerve and facilitate axonal regeneration. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 18, 2017 Category: Drugs & Pharmacology Source Type: research

A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo
Publication date: 1 March 2018 Source:Journal of Ethnopharmacology, Volume 213 Author(s): Mansour Sobeh, Mona F. Mahmoud, Mohamed A.O. Abdelfattah, Haroan Cheng, Assem M. El-Shazly, Michael Wink Ethnopharmacological relevance Cassia abbreviata is a small to medium sized branched umbrella-shaped deciduous tree. It is widely spread in the tropics, especially in Africa, having a long history in traditional medicine for the treatment of numerous conditions such as headaches, diarrhea, constipation, some skin diseases, malaria, syphilis, pneumonia, stomach troubles, uterine pains, and against gonorrhea. Aim of the study We inv...
Source: Journal of Ethnopharmacology - November 17, 2017 Category: Drugs & Pharmacology Source Type: research

Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model
Conclusion Our findings demonstrated for the first time that a subfraction from S. crispus, F3, is capable of activating the immune system in rats-bearing NMU-induced mammary tumor, which may contribute to the anticancer effects of F3, and additionally support the traditional use of S. crispus leaves to boost the immune system. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 17, 2017 Category: Drugs & Pharmacology Source Type: research

A thirteen-week oral toxicity study of So-ochim-tang-gami-bang, a traditional Korean medicine, in Sprague –Dawley rats
Conclusions The no-observed-adverse-effect-level of SOCG was determined to be above 5000mg/kg in both male and female rats. The result of this study can lay the foundation for the application of SOCG in humans and prove useful for detailed investigations on the toxicity or pharmacological effects of SOCG. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 16, 2017 Category: Drugs & Pharmacology Source Type: research

Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation
Conclusion Intestinal anti-inflammatory activity of P. paniculata was related to modulation of Mapks and mucin gene expression, as well as mucus secretion in intestinal inflammation. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 16, 2017 Category: Drugs & Pharmacology Source Type: research

Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: Chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity
Conclusions Although used indistinctly by folk medicine, our results suggested that AEJg is more active than AEJm in relation to its antiedematogenic and antibacterial activities. Significant differences were observed in their phytochemical profiles, especially a higher content of C-glycosylated flavonoids in the most active species, which could justify the different biological effects observed. These findings strengthen the potentiality of J. gossypiifolia species for use as complementary treatment for local effects induced by Bothrops venoms and could be helpful for distinction of the species and control quality assessme...
Source: Journal of Ethnopharmacology - November 16, 2017 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacological implications of quantitative and network analysis for traditional knowledge regarding the medicinal use of animals by indigenous people in Wolchulsan National Park, Korea
Conclusion This study validates that local communities use animals not only for food but also for medicinal purposes as crucial therapeutic measures. Therefore, the conservation of fauna and preservation of traditional knowledge need to be seriously considered to maintain the health and well-being of the local communities. Network analysis clarified the series of ailments for which each animal species is preferentially used and helped confirm the order of priority when prescribing animal components for medicinal use. The traditional knowledge recorded in the present study will provide the basic data to develop new medicine...
Source: Journal of Ethnopharmacology - November 16, 2017 Category: Drugs & Pharmacology Source Type: research

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats
Conclusions Our results not only confirm that Hugan Qingzhi exhibits a significant protective effect in HFD-induced NAFLD rats but also provide a better understanding for the treatments of NAFLD. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 7, 2017 Category: Drugs & Pharmacology Source Type: research

Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds
Conclusion P. erinaceus is confirmed as a plant harboring promising antibacterial activity with activities against serious human pathogens at very low concentrations. Some of the compounds isolated are also active at concentrations as low as 4µg/mL and therefore, may provide new leads for the development of antibacterial agents. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Development and formulation of Moringa oleifera standardised leaf extract film dressing for wound healing application
Conclusion A potentially applicable wound dressing formulated as an alginate-pectin film containing aqueous extracts of M. oleifera has been developed. The dressing would be suitable for wounds with moderate exudates. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise
Conclusions Oral administration of SFe, especially SFe500, enhanced exercise-induced adaptive muscle strengthening in aged mice after forced swimming through anti-apoptotic and anti-oxidant effects, mediated via modulation of gene expression related to muscle synthesis or degradation. These results suggest that SFe may be helpful in improvement various muscle disorders as an adjuvant therapy to exercise-based remedies. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide
Conclusions These findings suggest that Echinacea extracts and alkylamides may be useful for treating allergic and inflammatory responses mediated by mast cells. More broadly, since calcium is a critical second messenger, the inhibitory effects of alkylamides on calcium uptake would be predicted to dampen a variety of pathological responses, suggesting new uses for this plant and its constituents. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF- β/Smad signaling pathways
Conclusions SMEE and SMWE can significantly alleviate adenine-induced CRF via regulation of the metabolic profiling and modulation of NADPH oxidase/ROS/ERK and TGF-β/Smad signaling pathways, which provided important supports for the development of protective agent of SM for CRF. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

An ethnopharmacological survey of medicinal plants traditionally used for cancer treatment in the Ashanti region, Ghana
Conclusion A variety of traditionally used anti-cancer plants from Ghana have been identified and the widespread use within ethnotraditional medicine is obvious. Further in vitro and clinical studies will be performed in the near future to rationalize the phytochemical and functional scientific background of the respective extracts for cancer treatment. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba
Conclusion Sulfur-fumigation altered the pharmacokinetics, as well as reduced the safety and efficacy of BS, suggesting that sulfur-fumigation is not recommended for post-harvest handling of BS. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

The essential oil from Citrus limetta Risso peels alleviates skin inflammation: In-vitro and in-vivo study
Conclusion These findings suggested the preventive potential of Clp-EO for the treatment of inflammation linked skin diseases. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake
Conclusion The furanocoumarins rapidly and widely distributed into various tissues after oral dose of the RAD extract. IM, IIM, BER and OXYH were the major components detected in both plasma and tissues. Liver was the most distributed tissue of the total and free furanocoumarins. Non-specific protein binding contributed partially to the higher tissue exposures of these bioactive components. The Oatp and Oat mediated active uptake played the primal role in the high hepatic exposure of the furanocoumarins. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2017 Category: Drugs & Pharmacology Source Type: research