Nepeta angustifolia Attenuates Responses to Vascular Inflammation in High Glucose-Induced Human Umbilical Vein Endothelial Cells Through Heme Oxygenase-1 Induction
ConclusionAll these findings indicated that NA attenuated high glucose-induced vascular dysfunction in vitro and in vivo.Graphical abstractFig. 13. Schematic illustration of the potential molecular mechanisms of NA in reducing oxidative stress and inflammation. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Acetylcholinesterase Inhibitor from Anthocleista vogelii Leaf Extracts
ConclusionsThis study reports isolation and characetrization of a rare C-glycosylflavone; isovitexin-7-O-methyl ether (swertisin). Isolated compound exhibited duplication of NMR signals and better acetylcholinesterase inhibitory activity than eserine used as a standard. The activity exhibited by this compound suggests that it could be useful in the management of neurodegenerative diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Aqueous extract of Dipsacus asperoides suppresses lipopolysaccharide-stimulated inflammatory responses by inhibiting the ERK1/2 signaling pathway in RAW 264.7 macrophages
ConclusionThese results suggest that AEDA has anti-inflammatory and anti-oxidative effects through the inhibition of NF-κB and ERK1/2 and the activation of Nrf2/HO-1 in macrophages.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Actinidia Chinensis Planch Root Extract Attenuates Proliferation and Metastasis of Hepatocellular Carcinoma by Inhibiting Epithelial-Mesenchymal Transition
ConclusionsacRoots inhibited the malignant biological behavior of HCC cells via regulation of the epithelial-mesenchymal transition (EMT) by DLX2.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical characterization and evaluation of gastric antiulcer properties of the hydroethanolic extract of the stem bark of Virola elongata (Benth.) Warb
ConclusionThe HEVe exhibited significant gastroprotective/antiulcer effects and contain a relative high proportion of phenolic compounds, especially flavonoids, that could likely account, at least in part, for its pharmacological properties. The results justify its traditional usage and provided scientific evidence for its potential as a new herbal medicine to treat gastric ulcers.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacological Study of Anti-inflammatory Activity of Aqueous Extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker)
Publication date: Available online 9 November 2018Source: Journal of EthnopharmacologyAuthor(s): C.S.P. Della Pasqua, R.D. Iwamoto, E. Antunes, A.A. Borghi, A.C.F.H. Sawaya, E.C.T. LanducciAbstractEthnopharmacological relevanceMikania glomerata Spreng. (MG) and Mikania laevigata Sch. Bip. ex Baker (ML), popularly known as guaco, are medicinal plants similar in morphology, chemical composition and medicinal uses. Both species are often used and sold without distinction; however, it is believed that their chemical composition is different.AimThus, the aim of this study is to investigate if the aqueous extract of MG and ML pr...
Source: Journal of Ethnopharmacology - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Mycetia cauliflora methanol extract exerts anti-inflammatory activity by directly targeting PDK1 in the NF-κB pathway
ConclusionOur results suggest that Mc-ME displays anti-inflammatory actions in LPS-treated macrophage-like cells and in an animal model of acute inflammatory disease. These actions are preferentially managed by targeting PDK1 in the nuclear factor (NF)-κB signaling pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation
ConclusionOur results suggest that CASE inhibits HCC progression via mediating the interaction of miR-145/miR-21 and Smad3 phosphorylation, especially miR-145/miR-21 mediated Smad3 phosphorylation, which maybe provides an important theoretical foundation for CASE's anti-HCC therapy used for patients in a near future.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Ethnobotanical study on medicinal plants used by local Van Kieu ethnic people of Bac Huong Hoa Nature Reserve, Vietnam
ConclusionThe Van Kieu ethnic group holds valuable knowledge about uses of medicinal plant resources which is inherited through generations however this knowledge was not documented. The study highlights the need for documenting and publicizing the traditional medicinal knowledge which will provide basic data for further research and conservation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Bioguided identification of triterpenoids and neolignans as bioactive compounds from anti-infectious medicinal plants of the Taira Atacama's community (Calama, Chile)
ConclusionsGram positive strains of clinical interest were highly sensitive to Aloysia deserticola (Verbenaceae) and Krameria lappacea (Krameriaceae) extracts. The bioguided approach led us to identify the isolated neo-lignan from K. lappacea conocarpan (1), and triterpenoids form A. deserticola (oleanolic acid (6) and ursolic acid (10)), as the main bioactive compounds.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Medicines in the forest: ethnobotany of wild medicinal plants in the pharmacopeia of the Wichí people of Salta province (Argentina)
ConclusionsThe similarity of the current Wichí pharmacopoeia with the other ethnic groups of the region seem to respond more to a geographical proximity than to cultural affinity. Much (but not all) of their pharmacopoeia seem to be novel, resulting from a permanent seek for solutions to both old and new health problems in the native forests. Many medicinal plants, but not specific uses, seem to come from the neighbouring Criollos, whilst traditional remedies seem to be simultaneosly preserved. Hence, I propose that the ethnobotanical “diversification hypothesis”, slightly modified, applies in the case o...
Source: Journal of Ethnopharmacology - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Acridocarpus Smeathmannii (DC.) Guill. & Perr. Root enhanced reproductive behavior and sexual function in male wistar rats: Biochemical and pharmacological mechanisms
ConclusionOverall, the results obtained demonstrated the potential of HEASR as a male reproductive enhancer, thus justify its folklore applications. Further, octadecanoic acid ethyl ester was the most abundant bioactive component present.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

The ethnopharmacology, phytochemistry and pharmacology of Angelica biserrata- a review
ConclusionsA.biserrata has been proven as a valuable medicinal sources from triditional herb. Some conventional uses has been evaluated by pharmacological investigation. Although the crude extracts of A.biserrata has been emerged to possess more pharmacological activities, it is now time to isolate and identify more active chemical constituents by Bioactivity-Guided and elucidate their structure-activity relationship. More designed investigations are need to focus on understanding the multi-target network pharmacology, clarity the molecular mechanism of action and efficacy as well as identifying the effective doses of A.bi...
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of apigenin isolated from Aster yomena against Candida albicans: apigenin-triggered apoptotic pathway regulated by mitochondrial calcium signaling
ConclusionsApigenin isolated from A. yomena induced mitochondrial-mediated apoptotic pathway, and mitochondrial calcium signaling is main factor in its pathway in C. albicans.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models
Publication date: Available online 6 November 2018Source: Journal of EthnopharmacologyAuthor(s): Tanvi H. Desai, Shrikant V. JoshiAbstractEthnopharmacological relevanceAlbizia lebbeck (L.) Benth. (Family: Mimosaceae) is commonly known as Sirisha in Sanskrit. The leaves and pods of A. lebbeck were claimed to be used against cancer in traditional medicine. Previous studies using bark, leaves, seeds and pods of A. lebbeck showed cytotoxic activity against hepatic, colon, larynx, cervical and breast cancer cell lines.Aim of the studyTo evaluate the anticancer activity of saponin rich fraction of Albizia lebbeck by using variou...
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical composition of Acacia farnesiana (L) wild fruits and its activity against Mycobacterium tuberculosis and dysentery bacteria
ConclusionsThe activity of tested extracts and isolated compounds against M. tuberculosis and dysentery bacteria justifies the ethnomedical use of A. farnesiana fruits for the treatment of tuberculosis and dysentery.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

The ethanol extract of Involcucrum castaneae ameliorated ovalbumin-induced airway inflammation and smooth muscle thickening in guinea pigs
ConclusionIC alleviated airway inflammation and smooth muscle thickening in guinea pigs with OVA-sensitized allergic asthma. The paper explains the traditional efficacy and material basis of IC and lays a foundation for further development.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats
ConclusionsBased on the findings presented here, it has been concluded that TPSE has marked antidiabetic effects through various pathways on STZ/NA-induced diabetic rats and it may potentially be used as an effective treatment for type 2 diabetes mellitus (T2DM). Further research on isolation of the bioactive components is underway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of Paeonia emodi for its cardioprotective potentials: An investigative study towards possible mechanism
Publication date: Available online 2 November 2018Source: Journal of EthnopharmacologyAuthor(s): Muhammad Ibrar, Mir Azam Khan, Abdullah, Mohammad Nisar, Munasib KhanAbstractEthnopharmacological relevancePaeonia emodi Wall. ex Royle (peony) is an important member of family Paeoniaceae. Different parts of the plant have been folklorically used for treatment of different diseases. Infusion of dried flowers is used to treat diarrhea, the seeds are emetic and cathartic while the rhizome has been indicated for the treatment of hysteria, abdominal spasm, nervine tonic and headache. Besides these, peony has also been used in diff...
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

What do we know and what we would like to know about drone homogenate
ConclusionsThis paper presents the most important information on the use of drone brood in folk medicine. The studies carried out with the use of animals and humans have shown that the drone brood has an adjuvant effect that improves the efficiency of the organism. Due to its high content of amino acids and proteins, it is used as a tonic and adaptogenic agent. The presence of sex hormones in the homogenate allows its use as a potency raising agent and equalizing the hormonal system in people of both sexes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Aspidosperma species: A review of their chemistry and biological activities
ConclusionsAspidosperma subincanum and Aspidosperma tomentosum are used by the population of Brazil to treat many diseases. A few biological activities described for the extracts and isolated compounds of both species are in agreement with the ethnopharmacological use for others species of Aspidosperma, such as, antimalarial, the treatment of diabetes and other illnesses. These species are sources of leading compounds which can be used for developing new drugs. In addition, other biological activities reported and suggested by ethnopharmacological data have yet to be investigated and could be an interesting area in the sea...
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory action of an alkaloid, fraction and extract from Alchornea glandulosa in mice
ConclusionsTo the best of our knowledge, these results are the first to demonstrate that A. glandulosa exhibits oral and topical anti-inflammatory activity. This study detected alkaloid and phenol/polyphenolic compounds in A. glandulosa, which may help to explain the ethnobotanical use of this plant in traditional medicine in Brazil to treat immune-mediated inflammatory diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-κB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells
ConclusionsThese findings demonstrate for the first time the correlation between the anti-inflammatory activity of SCF4 and TLR-mediated NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 macrophage cells, suggesting that the non-aqueous extract of S. crispa could be applied as a promising natural product for the prevention and treatment of inflammatory diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit
Conclusionthe present result indicates that essential oil of Origanum majorana L. exhibit an effect on intestinal relaxation in vitro. This effect further validates the traditional use of Origanum majorana L. to treat infantile colic and abdominal discomfort.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection
Conclusions(1) DZY exhibits anti-RSV activities both in vitro and in vivo. (2) RSV infection can trigger a series of inflammatory reactions; thus, ameliorating inflammation is helpful to control the course of disease caused by RSV. These findings provide the rationale and scientific evidence behind the extensive use of L. gracile in traditional medicine for the treatment of diseases potentially caused by RSV.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Acridocarpus Smeathmannii (DC.) Guill. & Perr. Root Enhanced Reproductive Behaviour and Sexual Function in Male Wistar Rats: Biochemical and Pharmacological Mechanisms
CONCLUSIONOverall, the results obtained demonstrated the potential of HEASR as a male reproductive enhancer, thus justify its folklore applications. Further, octadecanoic acid ethyl ester was the most abundant bioactive component present.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Study of the accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration
ConclusionsAfter a single oral administration, the distribution and elimination of realgar in blood were slow, whereas it was rapidly absorbed and distributed in the liver, kidney and brain. Therefore, we recommend that realgar should not frequently used on a daily basis. Because the administration of a large dose of realgar did not display significant toxicity, we believe that the continuous administration of realgar for 30 days is safe in rats. In addition, hematology, biochemistry, and electrolyte levels and ECG should be monitored during realgar treatment. The accumulation and distribution of As species after 30 days o...
Source: Journal of Ethnopharmacology - October 30, 2018 Category: Drugs & Pharmacology Source Type: research

Momordica charantia L. lowers elevated glycaemia in Type 2 Diabetes Mellitus Patients: Systematic review and Meta-analysis
ConclusionM. charantia adjunct preparations improved glycemic control in T2DM patients. However, this conclusion based on low to very low quality evidences for the primary outcomes and sparse data for several safety outcomes, thus, warrant further research. Particularly needed are the researches that focus on standardizing M. charantia formulation and determine its efficacy and safety in clinical trials with adequate sample size, designed with random sequence generation, allocation concealment of intervention and blinding of both research personnel and participants.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 30, 2018 Category: Drugs & Pharmacology Source Type: research

Safety assessment of Piper cernuum Vell. (Piperaceae) leaves extract: Acute, sub-acute toxicity and genotoxicity studies
ConclusionsTogether, the results herein obtained indicate that P. cernuum leaves extract did not present significant toxicity when administered to male or female rats. Additionally, no significant alteration in hematological, biochemical and morphological parameters were observed. Data obtained in vitro shows that extract did not present cytotoxicity and mutagenicity. However, the extract induces in vitro genotoxicity, but in high concentration. Further studies are necessary to evaluate the safety of long-term exposure to P. cernuum leaves extract added to in vivo genotoxicity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 29, 2018 Category: Drugs & Pharmacology Source Type: research

Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis
This study was to evaluate the diuretic activity and the underlying mechanism of an ethanol extract of L. supina (LS) in a rat model of traumatic blood stasis (TBS).Materials and methodsThere were 30 male Sprague-Dawley rats that were randomly assigned to the control group, TBS group, and LS group (10 animals in each group). LS was administered orally (460 mg/kg) once daily for 7 days. The control group and TBS groups were given an equal amount of 0.3% sodium carboxymethyl cellulose (CMC-Na). For the efficacy evaluation, the urine output volume, the urinary electrolyte concentrations (Na+, K+, Cl- and Ca2+) and pH, th...
Source: Journal of Ethnopharmacology - October 29, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation
ConclusionsPro-sexual effects of P. auritum elicited at level of ejaculation were mediated by several neurotransmitter systems, among which serotonin and its 5-HT1A receptors play an important role. Present findings support P. auritum reputation as an aphrodisiac, with potential use in delayed ejaculation disorder.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Terminalia arjuna hydroalcoholic extract ameliorates trinitrobenzenesulphonic acid induced colitis mediated through inhibition of inflammation, oxidative stress and improvement in structure of gut microbiota
ConclusionTAHA administration relieved the disease activity in TNBS induced colitis by reducing expression of pro-inflammatory cytokines and chemokine, decreasing oxidative stress, and improving plasma zinc level and structure of gut microbiota.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 25, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical composition of Acacia farnesiana (L) Willd fruits and its activity against Mycobacterium tuberculosis and dysentery bacteria
ConclusionsThe activity of tested extracts and isolated compounds against M. tuberculosis and dysentery bacteria justifies the ethnomedical use of A. farnesiana fruits for the treatment of tuberculosis and dysentery.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 25, 2018 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Antipsoriatic effect of fatty acid enriched fraction of Vernonia anthelmintica Willd. fruits” [J. Ethnopharmacol. 224 (2018) 85–90]
Publication date: Available online 23 October 2018Source: Journal of EthnopharmacologyAuthor(s): Nittya K. Dogra, Suresh Kumar, Krishana Thakur, Dinesh Kumar (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 24, 2018 Category: Drugs & Pharmacology Source Type: research

Comparisons of antithrombosis, hematopoietic effects and chemical profiles of dried and rice wine-processed Rehmanniae Radix extracts
ConclusionsAccording to the results of this research, processing with rice wine for nine cycles significantly reduced antithrombotic effects and enhanced the hematopoietic effects of DRR as demonstrated in model mice. It can scientifically explain the different effect among two types of RR in clinical through the diverse method of processing and usage. Meanwhile, the predicted activity compounds from two types of RR can be potential candidates for the treatment of thrombosis and anemia.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

The ethanol extract of Involucrum castaneae ameliorated ovalbumin-induced asthma in guinea pigs
ConclusionThe paper explains the traditional efficacy and material basis of IC and lays a foundation for further development.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Myorelaxant Activity of essential oil from Origanum majorana L on rat and rabbit
Conclusionthe present result indicates that essential oil of Origanum majorana L. exhibit an effect on intestinal relaxation in vitro. This effect further validates the traditional use of Origanum majorana L. to treat infantile colic and abdominal discomfort.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacological study of Sephardic remedies in the 19th century: the “Livro de Milizinas”
ConclusionsThe Sephardic materia medica presented in the “Livro de Milizinas” is eclectic, adapted to an urban environment and to the prevalent pathologies of the second half of the 19th century, within the main cultural framework of the Ottoman Empire but with peculiarities characteristic of Sephardic Culture. These can be traced back to the period immediately after the expulsion of Sephardic from Spain. Their relationships with other modern sources are scarce, even in terms of pathologies.Graphical Abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 22, 2018 Category: Drugs & Pharmacology Source Type: research

Standardization and xanthine oxidase inhibitory potential of Zanthoxylum armatum fruits
ConclusionMost potent three chemicals (ZA-2, 6 and 7) could be considered as bioactive to ensure the robust quality of the enriched fraction of ZAF with defined XO inhibition potential. Therefore, either single purified component or their enriched fraction could be a better choice for the management of gout than the crude extract of ZAF. Developed HPLC method is suitable for quality assurance analysis and process control of ZAF derived product intended for gout management. XO inhibitory potential exhibited by the characterized compounds validate the traditional use of this ZAF for the treatment of gout. Further, a detailed...
Source: Journal of Ethnopharmacology - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice
ConclusionThese data demonstrate that RDP ameliorates renal fibrosis through TGF-β/Smad and MAPK pathways in a UUO mouse model.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes
Publication date: Available online 18 October 2018Source: Journal of EthnopharmacologyAuthor(s): Gabriel O. Anyanwu, Jamshed Iqbal, Shafi U. Khan, Sumera Zaib, Khalid Rauf, Chukwu E. Onyeneke, Opeolu O. Ojo, Nisar-ur-RahmanAbstractEthnopharmacological relevanceAnthocleista vogelii Planch is a medicinal plant traditionally used in West Africa for the management and treatment of diabetes mellitus.Aim of the studyTo determine the antidiabetic activities of chloroform fraction (CF) of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes.Materials and MethodsInhibitory activities of CF a...
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Reversing Effects of Ginsenosides on LPS-induced Hepatic CYP3A11/3A4 Dysfunction Through the Pregnane X Receptor
ConclusionGinsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Memory enhancing, anticholinesterase and antimicrobial activities of β-phenylnitroethane and essential oil of Dennettia tripetala Baker f
ConclusionThe most abundant component - β-phenylnitroethane of D. tripetala was totally responsible for its memory enhancing properties but could not solely account for its antimicrobial activity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

An in vitro validation of the therapeutic effects of Tougu Xiaotong capsule on tunicamycin-treated chondrocytes
ConclusionsThe present study provides evidence of the therapeutic effects of TXC at the cell level and describes a cellular model for establishing the mechanisms of the effects of TXC used in the treatment of OA.Graphical abstractER stress pathway may play a role in the mechanisms of TXC. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Male sexual enhancers from the Peruvian Amazon
ConclusionThe traditional preparations used to improve sexual performance in the Peruvian Amazon showed activity as phosphodiesterase-5 inhibitors. The most active ingredient of the traditional preparations was C. angustifolia, with some contribution from T. panurensis. These results encourage additional studies, including animal models to confirm the male enhancer effect of the preparations.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Airway smooth muscle relaxant activity of Cordia dodecandra A. DC. mainly by cAMP increase and calcium channel blockade
ConclusionsResults suggest that DECd-b induces relaxation mainly by cAMP increase and Ca2+ channel blockade. The chromatographic profiles and UV spectrum of DECd-b and HECd-l suggest the presence of molecules with structure of meroterpenoid naphthoquinones. This work report scientific evidence of C. dodecandra medicinal specie, which contributes to the pharmacological and phytochemical background of C. dodecandra providing an added value to the traditional use of this specie.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Linking resource supplies and price drivers: lessons from Traditional Chinese Medicine (TCM) price volatility and change, 2002 − 2017
ConclusionsPrice fluctuations in the four TCM species we examined are influenced by many factors and not just resource scarcity. And the situation is more complex than the trajectory based on Homma's (1992) model, where he predicted that higher prices would result in a shift to cultivation, thus replacing wild harvest. In case of both O. sinensis and P. polyphylla, Homma (1992, 1996) was right in terms of scarcity and high prices stimulating a major investment in cultivation (P. polyphylla) and artificial production (O. sinensis). But in both cases, intensive production through cultivation or artificial propagation do not ...
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Incompatibility assessment of Genkwa Flos and Glycyrrhizae Radix et Rhizoma with biochemical, histopathological and metabonomic approach
ConclusionThe toxicities of YH and YH-GC combination above the Chinese Pharmacopoeia dose were obvious but different. Metabonomics combined with biochemical and histopathological methods can be applied to elucidate the toxicity mechanism of the YH-GC combination that caused liver, kidney and reproductive injuries in rats.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 18, 2018 Category: Drugs & Pharmacology Source Type: research