Chemical composition and antimicrobial activity of Myrcianthes fragrans essential oil, a natural aromatizer of the traditional Ecuadorian beverage colada morada
ConclusionsThe oil is characterized by a high concentration of the monoterpene aldehydes geranial and neral (citral), that make the aroma of colada morada prepared in southern Ecuador quite different from the beverage made in other regions of the country, where other types of myrtles (Myrtaceae spp.) are used. Moreover, the oil may become a new rich source of the important industrial chemical citral. The pleasant aromatic properties and the good in vitro antimicrobial activity of arrayán oil suggest a plausible scientific explanation for the traditional uses of the plant not only as a natural aromatizer of a traditi...
Source: Journal of Ethnopharmacology - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity
ConclusionsThirty-seven plants commonly used by the tribes of the CRF as anti-infective agents offer perspectives for further research, as the phytochemistry and phytopharmacology for most of these plants have not been published to date.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 11, 2018 Category: Drugs & Pharmacology Source Type: research

Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis
This study aimed to evaluate the beneficial effects of ginger on the intestinal damage in an experimental rat model of NEC.Materials and MethodsThirty newborn Wistar rats were divided into three groups: NEC, NEC + ginger and control in this experimental study. NEC was induced by injection of intraperitoneal lipopolysaccharide, feeding with enteral formula, hypoxia-hyperoxia and cold stress exposure. The pups in the NEC + ginger group were orally administered ginger at a dose of 1000 mg/kg/day. Proximal colon and ileum were excised. Histopathological, immunohistochemical (TUNEL for apoptosis, caspase 3 and 8) and bioch...
Source: Journal of Ethnopharmacology - July 11, 2018 Category: Drugs & Pharmacology Source Type: research

The Chinese herbal formula Zhibai Dihuang Granule treat Yin-deficiency-heat syndrome rats by regulating the immune responses
Publication date: Available online 2 May 2018Source: Journal of EthnopharmacologyAuthor(s): Chang-Ming Liu, Jing Chen, Su Yang, Lian-Gen Mao, Ting-Ting Jiang, Hui-Hui Tu, Zhong-Liang Chen, Yu-Ting Hu, Lin Gan, Zhong-Jie Li, Ji-Cheng LiAbstractEthnopharmacological relevanceZhibai Dihuang Granule (ZDG), a traditional Chinese medicine (TCM) made from eight Chinese herbs, has been classically used to treat Yin-deficiency-heat (YDH) syndrome. ZDG is well known with the therapeutic efficacy of nourishing Yin and decreasing internal heat in clinic, but the mechanism of ZDG's therapeutic effect is still not clear.Materials and met...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty acids and fatty alcohols
ConclusionsOur results show that T. laxiflora and T. brownii contain antimycobacterial compounds of diverse polarities and support the traditional uses of various parts of T. laxiflora and T.brownii as decoctions for treatment of tuberculosis. Further investigations are warranted to explore additional (new) antimycobacterial compounds in the active extracts of T. laxiflora and T. brownii.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs
Publication date: Available online 8 May 2018Source: Journal of EthnopharmacologyAuthor(s): Xu Yan, Hongjin Wu, Jianxun Ren, Yuna Liu, Shengqi Wang, Jiyuan Yang, Shuyan Qin, Delin WuAbstractEthnopharmacological relevanceShenfu decoction consists of the water extract from the dried root or rootstalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (Fuzi, Heishunpian in Chinese). Shenfu Formula has been used as a folk Chinese medicine for thousands of years. Recent studies have shown that Shenfu injection can enhance cardiac function and regulate arrhythmia.Aim of the studyShenfu F...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-arthritic activities of ethanol extracts of Circaea mollis Sieb. & Zucc. (whole plant) in rodents
ConclusionOur work demonstrated that EEC possessed the potential therapeutic effect against arthritis in rodents which was attributed to modulating proinflammatory cytokines TNF-α, IL-1β and anti-inflammatory factors IL-10. Flavonoids and polyphenols may contribute to the therapeutic effect of EEC on arthritis.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Immune modulation of a novel lipid-soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor-burdened mouse model
ConclusionsThese findings linked the anti-tumor properties of PE with the immune microenvironment to present a reliable basis for the future practical application of PE in cervical cancer as a novel and pharmacologically safe immunotherapy strategy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
ConclusionIn silico, in vitro, in vivo, and clinical studies strongly suggest that the major pharmacological mechanism of luteolin is its anti-inflammatory activity, which derives from its regulation of transcription factors such as STAT3, NF-κB, and AP-1. Much work remains to ensure the safety, quality, and efficacy of luteolin before it can be used to treat inflammation-related diseases in humans.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio)
In this study, a group with 1% ethanol, one with unpredictable chronic mild stress (UCMS), and another with developmental social isolation (DSI) were used as induction groups for depression-like behavior and fluoxetine (20 mg/kg) as a drug pattern.Resultsby the HPLC-UV fingerprint analysis, the HELSm presents several derivatives of polyphenolic compounds and flavonoids and identified ellagic acid and isoquercitrin and by the gas-chromatographic, the majority of the identified compounds were fatty acids, esters and alcohols. By immersion, the LC50 was 49.86 mg/l and by oral via the LD50 in 48 hours, was 4.515 g/kg in zebraf...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Active components, derived from Kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor NGF and BDNF on mouse astrocyte primary cultures via cAMP-dependent signaling pathway
ConclusionsThe active compounds of KXS on increasing NGF and BDNF expressions might be the ginsenosides via activating cAMP-dependent signaling pathway as well as stimulating enzymes accounting for neurotrophic factor synthesis, which partly reveal the target of this formulae supported the clinically usage of this decoction.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

In vivo and in vitro anti-inflammatory effects of Sophora flavescens residues
ConclusionsThe residues of S. flavescens had obvious flavonoids with anti-inflammatory activity. This study provided evidence for the reuse of residues from S. flavescens in the food additive, medicine and cosmetic industries.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The venom of spider Haplopelma hainanum suppresses proliferation and induces apoptosis in hepatic cancer cells by caspase activation in vitro
ConclusionThe results indicated that the venom of H. hainanum exhibited potent inhibition effects in HepG2 cells through suppressing proliferation, reducing the mitochondrial membrane potential, activating caspase-3 and caspase-9, and inducing the apoptosis through a mitochondrial-dependent pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Potential therapeutic applications of the genus Annona Local and traditional uses and pharmacology
ConclusionsThe experimental results from the pharmacological research enable the validation of their traditional uses in several of the groups of diseases in the countries of origin and reveal these plants to be a valuable source for therapeutic molecules. However, more toxicity assays and clinical trials would be necessary to establish optimal and safe doses of consumption on the application of these medicinal plants.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Prescription Patterns and Characteristics of Users of Chinese Herbal Products in the US: Analysis of a Teaching Center Prescription Database
Publication date: Available online 20 June 2018Source: Journal of EthnopharmacologyAuthor(s): Kai-Yin Hsu, Kenneth Kwan Ho Chui, Lisa ConboyGraphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Twists, turns and trade: a new look at the Indian Screw tree (Helicteres isora)
ConclusionsIndia is the major exporter of whole dried H. isora fruits, including to countries where this species has never been in traditional use. In Indonesia, H. isora fruit extracts are used in the cosmetic industry as well as in jamu herbal medicines, including “Tolak Angin”, the country's most popular commercial “jamu” preparation. Indonesia also is the major importer of H. isora fruits from India. In eastern Indonesia, improved income to local villagers from the H. isora fruit trade could come from improved H. isora fruit quality due to better drying techniques. This would also reduce health ...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Lycium europaeum Linn as a source of polysaccharide with in vitro antioxidant activities and in vivo anti-inflammatory and hepato-nephroprotective potentials
CONCLUSIONOverall, the findings of this study support the traditional use of L. europaeum L. and maybe a good agent for protection against inflammatory diseases and hepato-renal injuries in patients with cancer.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Oral administration of Aristolochia manshuriensis Kom in rats induces tumors in multiple organs
ConclusionsAMK had significant toxic effects in rats with regard to decreased body weight, diminished renal and liver function, increased anemia and tumor incidence. Kidney, stomach, bladder and subcutaneous tissue are carcinogenic target organs of AMK or AAs, however liver is no- carcinogenic target organ of AMK or AAs in rats. AMK is carcinogenic in rats, and not be safe for humans.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-Deinagkistrodon acutus venom properties of ethanolic root extract from Cynanchum paniculatum and its GC-MS analysis
ConclusionsThe results obtained in this work validate for the first time CPER as a traditional antiophidic herb, especially inhibitory effect on local damage induced by DAV, suggesting it could be used as a potential source of bioactive components against snakebites.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways
ConclusionsBoth RIA and SIA aqueous extracts showed anti-inflammatory effects in vivo in a dose-independent manner (20‒80 and 40‒160 mg/kg, respectively). The underlying mechanisms are mediated by inhibiting the pro-inflammatory cytokines TNF-α, IL-6, and IL-1β via regulation of the NF-κB, JAK2/STAT3, and MAPK signaling pathways. The present results provided pharmacological evidence that stems are alternative medicinal parts of IA but function at different doses. Additionally, this study supports the use of IA as an anti-inflammatory herbal medicine.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Arbutus unedo L.: From Traditional Medicine to Potential Uses in Modern Pharmacotherapy
ConclusionThis review suggests that A. unedo is a promising source of phytopharmaceutical products. The potential advantages of Arbutus unedo are related with the presence of polyphenolic compounds in its composition. However, further studies are needed to ascertain some profitable effects in humans. The beneficial effects associated with this shrub suggest that Arbutus unedo can be used for the development of new drugs to treat diseases such diabetes, hypertension, among others. Nonetheless, the safety of the Arbutus unedo compounds should also be examined.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS
ConclusionsThe results support the merit of P. alkekengi as an antidiabetic herbal medicine or dietary supplement.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aqueous extract of Sedum oxypetalum induces mineralization and osteogenic differentiation by human Periodontal Ligament-Derived cells
ConclusionThe findings reported herein support the traditional use of S. oxypetalum due to its potential capacity to promote the regeneration of mineralized tissues.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ethnomedicinal plants and traditional knowledge among three Chin indigenous groups in Natma Taung National Park (Myanmar)
ConclusionThis study presents the diversity of ethnomedicinal plants and their local importance in Chin indigenous peoples’ healthcare. This paper also recognizes the value of these plants and the local traditional knowledge for the conservation and management of NTNP.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance
ConclusionIn vitro and in vivo studies have confirmed the potency of A. officinarum. However, further studies are required to establish the mechanisms mediating its bioactivities in relation to the medicinal uses as well as investigating any potential toxicity for future clinical studies.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review
ConclusionsModern pharmacological studies have supported many traditional uses of A. oxyphylla, including nervous system, urinary system and gastrointestinal system disease. There was convincing evidence in experimental animal models in support of its neuroprotection, secure essence, reduce urination, and anti-carcinogenic effects. However, all the reported pharmacological activities were carried out at pre-clinical level and the authors urge further investigation in clinical trials about these therapeutic fields of A. oxyphylla.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology
ConclusionsTrichosanthis Fructus is an essential traditional Chinese medicine with pharmacological activities that mainly affect the cardiovascular system. This review summarises its botany, traditional uses, phytochemistry and pharmacology. Future research is needed to clarify the different uses of the seeds, pericarps and fruits. Quality control of investigations of the fruits should be improved, and the potential uses of the flesh, leaves and twigs should be further explored.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Bioactive compounds and health benefits of some palm species traditionally used in Africa and the Americas – A review
ConclusionsPalms have provided bioactive samples that validate their effectiveness in traditional medicine. However, the intensive study of all palm species related to ethno-medicinal use is needed, along with selection of the most appropriate palm accessions, ripe stage of the fruit and /or part of the plant. Furthermore, the complete profiles of all phytochemicals, their effects on animal models and human subjects, and toxicological and clinical trials are suggested, which, added to the incorporation of improved technological processes, should represent a significant advance for the implementation of new opportunities wi...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The use of medicinal plants by pregnant women in Africa: A systematic review
ConclusionsThe use of MPs among pregnant women in Africa is prevalent, and the most commonly used plant species are not known to have harmful foetal effects during pregnancy. However, many of the MP species are poorly studied and teratogenic effects cannot be ruled out. Collaboration between healthcare providers and traditional practitioners to inform about the safe use of MPs may promote safer pregnancies and better health for mothers and infants.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The genus Pterocaulon (Asteraceae) – A review on traditional medicinal uses, chemical constituents and biological properties
ConclusionsPterocaulon species, a rich source of coumarins, have great ethnomedical potential. Nevertheless, further studies into the pharmacological activities are necessary since none of the purported effects of these plants was fully assessed. In-depth research regarding the toxicity are also required to ensure the safety of these medicinal plants.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials
This study aimed to assess the efficacy and safety of XBJ combined with routine treatment (RT) for treating sepsis through systematic review and meta-analysis.Materials and methodsDatabases including Embase, PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP) and the Wanfang database were searched from inception to June 6, 2017 to collect relevant RCTs comparing XBJ combined with RT and RT alone for sepsis. The primary clinical outcomes were 28-day mortality and mortality during treatment. The secondary outcomes of...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation of the therapy targets of Yi-Qi-Yang-Yin-Hua-Tan-Qu-Yu recipe on type 2 diabetes by serum proteome labeled with iTRAQ
ConclusionsYQYYHTQY recipe showed therapy effect on T2DM. CDC42 and RhoA proteins were the therapy targets of YQYYHTQY recipe.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-allergy and anti-tussive activity of Clitoria ternatea L. in experimental animals
ConclusionsStandardized ECT could be considered as a potential therapeutic alternative in the management of allergy-induced asthma.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antidiarrheal activity of a novel sulfated polysaccharide from the red seaweed Gracilaria cervicornis
ConclusionsIn conclusion, PLS has a significant antidiarrheal effect in acute and secretory diarrhea. Further investigation is needed towards its use as a natural medicine to treat diarrhea.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Comparative pharmacokinetics of six coumarins in normal and breast cancer bone-metastatic mice after oral administration of Wenshen Zhuanggu Formula
Publication date: 5 October 2018Source: Journal of Ethnopharmacology, Volume 224Author(s): Weiling Chen, Jiajia Li, Zhenping Sun, Chunyu Wu, Jiao Ma, Jianyi Wang, Sheng Liu, Xianghui HanAbstractEthnopharmacological relevanceWenshen Zhuanggu Formula (WSZG) is a traditional Chinese medicine (TCM) prescription used in clinics for adjuvant treatment of breast cancer bone metastases in Longhua Hospital in China. WSZG has been reported to decrease the risk of bone metastases and alleviate the severity of bone lesions in a breast cancer xenograft model.Aim of the studyThe present study aimed at investigating the pharmacokinetic b...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells
ConclusionThese findings provide experimental evidence supporting the potential application of I. obliquus in lung cancer treatment and reveal the molecular basis underlying its cytotoxic activity against human lung cancer cells.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Acute and subacute toxicity and chemical constituents of the hydroethanolic extract of Verbena litoralis Kunth
ConclusionsThe extract of the aerial parts of Verbena litoralis did not present significant toxicity when administered a single dose. However, when different doses were administered for 28 days, were observed changes in hematological, biochemical and histological parameters in rats.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antipsoriatic effect of fatty acid enriched fraction of Vernonia anthelmintica Willd. fruits
Publication date: 5 October 2018Source: Journal of Ethnopharmacology, Volume 224Author(s): Nittya K. Dogra, Suresh Kumar, Krishana Thakur, Dinesh KumarAbstractEthnopharmacological relevanceVernonia anthelmintica has been utilized conventionally as an ingredient in Ayurveda and traditional Uighur medicine for management of various skin ailments, and scientific data's have substantiated its use in treating vitiligo, dermatosis and leucoderma. The present investigation was focused to evaluate the antipsoriatic activity of V. anthelmintica fruit extracts and fractions.Materials and methodsOintment containing dichloromethane (D...
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The enhancing effect of Aubang Gahl Soo on the hippocampal synaptic plasticity and memory through enhancing cholinergic system in mice
ConclusionsThese results suggest that AGS facilitates hippocampal LTP through activating cholinergic system and ameliorates cholinergic dysfunction-induced memory deficit.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic potential of root and stem bark of wild medicinal plant Ziziphus mauritiana (Lamk.) against silica induced toxicity in Wistar albino rats
ConclusionResults of this study has suggested that the extracts of root and stem bark of ZM can be used for therapeutic purpose to prevent silica induced toxicity. ZM extracts could be utilised as natural antioxidant and immunotherapeutic medicines to protect silica induced cell damage.Graphical abstractSchematic diagrammatic representation showing therapeutic potential of Ziziphus mauritiana in silica induced toxicity. ⇧ Arrow indicates increase the level after exposure of silica, ⇩ Arrow indicates decrease the level after extracts treatment. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Diuretic herb Gomphrena celosioides Mart. (Amaranthaceae) promotes sustained arterial pressure reduction and protection from cardiac remodeling on rats with renovascular hypertension
ConclusionsThe G. celosioides diuretic effect is maintained on renovascular hypertensive rats and can reduce the blood pressure after the first week of treatment by inhibiting ACE and these effects are longstanding and strong enough to promote protection against cardiac remodeling. Therefore, it shows potential as an antihypertensive drug.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Jianpi Jiedu decoction, a traditional Chinese medicine formula, inhibits tumorigenesis, metastasis, and angiogenesis through the mTOR/HIF-1α/VEGF pathway
ConclusionsJPJD treatment produced anti-colorectal tumor effects by inhibiting tumorigenesis, metastasis, as well as angiogenesis through the mTOR/HIF-1α/VEGF pathway. Thus, these results provide a strong rationale for the therapeutic use of JPJD in cancer treatment. Further studies are required to investigate the mechanisms underlying anti-CRC effect of JPJD.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Typhae pollen polysaccharides ameliorate diabetic retinal injury in a streptozotocin-induced diabetic rat model
ConclusionsTPP treatment ameliorated DR by inhibiting inflammation and improving blood circulation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The polysaccharide-rich tea of Ximenia americana barks prevents indomethacin-induced gastrointestinal damage via neutrophil inhibition
ConclusionTPL and Tea of Ximenia americana barks ameliorate the gastric injury induced by indomethacin in mice, an effect that was dependent on the reduction of neutrophil infiltration.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr
ConclusionThe present study identified the cardiac glycosides as potential active constituents associated with wound healing and might afford a chemical foundation for preparation development of crude drug and quality evaluation of relevant products.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats
ConclusionsThe obtained results indicated that FCAE exhibits a natural laxative effect without provoking diarrhea and ameliorates functional gastrointestinal (GI) and motility disorders thus justifying its traditional usage.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa
ConclusionThe results indicate that Heteromorpha trifoliata and Phymaspermum acerosum should be investigated further for antimycobacterial efficacy against drug resistant strains of Mycobacterium.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways
ConclusionsFlavonoid C1 from C. tinctoria was protective in experimental AP and this effect may at least in part be attributed to its antioxidant effects by activation of Nrf2-mediated pathways. These results suggest the potential utilisation of C. tinctoria to treat AP.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats
ConclusionOur results demonstrate that PLFO display significant prophylactic and therapeutic effects against gastric ulcers. Importantly, the mechanism underlying PLFO activities might implicate inhibition of inflammatory responses during gastric ulcer.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-hepatitis B virus effects of the traditional Chinese herb Artemisia capillaris and its active enynes
ConclusionsEnynes are responsible for the anti-HBV effects of A. capillaris. Hydroxyl and glycosyl groups are preferable for maintaining activity. This is the first time to systematically investigate the anti-HBV activity of enynes in A. capillaris, which provides valuable information for understanding the ethnopharmacological application of Yin-Chen.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research