Anti-inflammatory and wound healing effects of gel containing Kaempferia marginata extract
ConclusionThe present study shows that gel containing K. marginata extracts have good anti-inflammatory and wound healing properties in vitro.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 20, 2019 Category: Drugs & Pharmacology Source Type: research

Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. In loperamide-induced rats
Publication date: Available online 15 May 2019Source: Journal of EthnopharmacologyAuthor(s): Bingyou Yang, Xiaomao Li, Yan Liu, Wei Guan, Haixue KuangAbstractEthnopharmacological relevanceAnemarrhena asphodeloides Bge. Is a traditional Chinese medicine used in treating constipation.Aim of the study: To investigate the laxative activities and the potential mechanism of polysaccharides obtained from Anemarrhena asphodeloides Bge. (AABP).Materials and methodsThe experiment was performed using the following techniques: enzyme-linked immuno sorbent assay (ELISA), histopathological, immunohistochemistry, western blotting and rea...
Source: Journal of Ethnopharmacology - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Title: Rhamnus prinoides (gesho): A source of diverse anti-biofilm activity
ConclusionGesho leaf ethanol extract contains chemicals with anti-biofilm and bactericidal activities. This work lends support to the traditional use of gesho for treating topical infections and warrants further investigation into Rhamnus prinoides as a source of antibacterial and anti-biofilm agents.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Diuretic activity and neuropharmacological effects of an ethanol extract from Senna septemtrionalis (Viv.) H.S. Irwin & Barneby (Fabaceae)
ConclusionThe diuretic effects of SSE involve the possible contribution of prostaglandins and nitric oxide. SSE showed moderate anxiolytic and anticonvulsant effects, whereas the participation of α2-adrenoceptors is probably associated in the antidepressant-like effects of SSE.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart
Publication date: Available online 15 May 2019Source: Journal of EthnopharmacologyAuthor(s): Alyne Rodrigues de Araújo, Bruno Iles, Kerolayne de Melo Nogueira, Jhones do Nascimento Dias, Alexandra Plácido, Artur Rodrigues, Patrícia Albuquerque, Ildinete Silva-Pereira, Renato Socodatto, Camila C. Portugal, João B. Relvas, Leiz Maria Costa Véras, Filipe Camargo Dalmatti Alves Lima, Augusto Batagin-Neto, Jand-Venes Rolim Medeiros, Paulo Humberto Moreira Nunes, Peter Eaton, José Roberto de Souza de Almeida LeiteAbstractEthnopharmacological RelevanceFolk knowledge transmitted between ge...
Source: Journal of Ethnopharmacology - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

Rosa rugosa flavonoids exhibited PPARα agonist-like effects on genetic severe hypertriglyceridemia of mice
ConclusionRRFs can reduce plasma TG levels by repressing the expression of ApoC3 and inducing the expression of LPL in liver. RRFs could also reduce triglyceride in hepatocytes through increasing β-oxidation and decreasing synthesis of the lipids. These findings show the potency of further clinical application of RRFs as a hypolipidemic drug for treatment of cardiovascular diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

Safety assessment of Gyejibokryeong-hwan water extract: Study of acute and subacute toxicity, and influence on drug metabolizing enzymes
ConclusionsOur present data suggest that GBHW does not cause toxicologically important adverse events at doses up to 2000 mg/kg/day in the 4-week repeated dose toxicity study and provide valuable information concerning its potential to interact with conventional medicine.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Chemical profiling of secondary metabolites of Eugenia uniflora and their antioxidant, anti-inflammatory, pain killing and anti-diabetic activities: A comprehensive approach
ConclusionA plethora of substantial pharmacological properties indicate that Eugenia uniflora is a good antioxidant and a sustainable by-product with potential therapeutic potential for treating diabetes, inflammation, pain and related oxidative stress diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells
ConclusionsInduction of apoptosis and inhibition of CYP1A1, CYP1B1, GSTP1, MRP1 and MRP2 mRNA expression implies that T. chamaedrys can serve as a valuable source of bioactive compounds as dietary supplements or selective anticancer agents, with the ability to induce apoptosis and modulate drug resistance in colorectal cancer cells.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 12, 2019 Category: Drugs & Pharmacology Source Type: research

The ethyl acetate extracts of radix trichosanthis protect retinal vascular endothelial cells from high glucose-induced injury
ConclusionsERT suppressed high glucose-induced injury in REVC by regulating the Hippo and Notch signaling pathways.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 12, 2019 Category: Drugs & Pharmacology Source Type: research

Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats
ConclusionCCEC enhanced gastrointestinal motility probably through rebalancing the homeostasis of brain-gut-microbiota axis in FD rats. The novel findings may provide insightful theoretical basis for its clinical employment.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

The RUTI trial: A feasibility study exploring Chinese herbal medicine for the treatment of recurrent urinary tract infections.
ConclusionCHM can fulfil the demanding requirements of a CTIMP study but it may not be feasible at this point in time to recruit and treat via NHS primary care. However acceptable rates of recruitment and retention via self-help groups and promising preliminary results in the individualised arm suggest it would be worth testing this approach in a full trial.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 10, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacological mechanism of Sishen Wan® attenuated experimental chronic colitis by inhibiting wnt/β-catenin pathway
ConclusionsSSW effectively attenuated experimental chronic colitis induced by TNBS, which was realized by inhibition of the Wnt/β-catenin signaling pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 10, 2019 Category: Drugs & Pharmacology Source Type: research

The polyherbal composition Gyeongshingangjeehwan 18 attenuates glucose intolerance and pancreatic steatosis in C57BL/6J mice on a high-fat diet
This study was undertaken to investigate the effects of GGEx18 on glucose metabolism and pancreatic steatosis in obese C57BL/6 J mice fed a high-fat diet (HFD) and to examine the related cellular and molecular mechanisms.Materials and methodsThe mice were grouped and fed for 13 weeks as follows: 1) low-fat diet, 2) HFD, or 3) HFD supplemented with GGEx18 (500 mg/kg/day). Various factors affecting insulin sensitivity and pancreatic function were then assessed via blood analysis, histology, immunohistochemistry, and real-time polymerase chain reaction.ResultsGGEx18 treatment of obese mice reduced body weight, total fat, ...
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

The repression and reciprocal interaction of DNA methyltransferase 1 and specificity protein 1 contributes to the inhibition of MET expression by the combination of Chinese herbal medicine FZKA decoction and erlotinib
ConclusionFZKA decreases MET gene expression through the repression and mutual regulation of DNMT1 and SP1 in vitro and in vivo. This leads to inhibit the growth of human lung cancer cells. The combination of FZKA and EGFR-TKI erlotinib exhibits synergy in this process. The regulatory loops among the DNMT1, SP1 and MET converge in the overall effects of FZKA and EGFR-TKI erlotinib. This in vitro and in vivo study clarifies an additional novel molecular mechanism underlying the anti-lung cancer effects in response to the combination of FZKA and erlotinib in gefitinib-resistant NSCLC cells.Graphical abstract (Source: Journal...
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Establishment of an in vitro system based on AGM-S3 co-culture for screening traditional herbal medicines that stimulate hematopoiesis
ConclusionsOur results demonstrate that catechin, an active ingredient of Spatholobus suberectus Dunn, can increase the efficiency of hematopoiesis, including hematopoietic and erythroid progenitors, consistent with previous reports. The AGM-S3 co-culture system could provide an effective tool for screening active compounds in TCMs that promote hematopoiesis, and may be of clinical and pharmaceutical use.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

The Chinese herbal formulae (Yitangkang) exerts an antidiabetic effect through the regulation of substance metabolism and energy metabolism in type 2 diabetic rats
ConclusionThese results were consistent with the TCM description of YTK as a “cold” treatment. It could provide an effective way to interpret the scientific connotation and comprehensive system of the Chinese herbal formulae.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro
ConclusionsHLJDT significantly improved AD-like symptoms via inhibition of the MAPKs/NF-κB pathway. Therefore, administration of HLJDT might be a potential treatment for AD in the clinical setting.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Induction of EpRE-mediated gene expression by a series of mediterranean botanicals and their constituents
ConclusionsThe protective effect of half of the tested botanical varieties via the activation of EpRE-mediated gene expression was confirmed. The study also provided an example of how in vitro bioassays can be combined with LC-MS and the automated chemical annotation software MAGMa, to identify biologically active constituents in complex botanical extracts.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Antinociceptive and antioxidant effects of extract enriched with active indole alkaloids from leaves of Tabernaemontana catharinensis A. DC.
ConclusionsThe results justify the use of this plant in traditional medicine. in vivo tests indicate that these compounds possess central and peripheral mechanisms of action. This is study that reports the nociceptive action of these alkaloids, also including toxicity tests, which are intended to guarantee the safety of use of extracts of this plant.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal plant species used by local communities around Queen Elizabeth National Park, Maramagambo Central Forest Reserve and Ihimbo Central Forest Reserve, South western Uganda
ConclusionsA variety of medicinal plants are used by communities living near protected areas in South Western Uganda. Most species were used in the treatment of digestive disorders, followed by general and unspecified disorders. Much as allergy has not been identified as a major threat by the health sector in Uganda, the study found out that it is one of the prevalent ailments in the study area. While the therapeutic value of some of the documented medicinal plant species, especially those with higher frequency of citation have been scientifically validated, the efficacy and safety of other species with wide application ne...
Source: Journal of Ethnopharmacology - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Investigation of the anti-inflammatory and the analgesic effects of the extracts from Smilax ornata Lem. (Jamaican sarsaparilla) plant
Publication date: Available online 4 May 2019Source: Journal of EthnopharmacologyAuthor(s): Ahmad K. Khan, Paul D. Singh, Paul B. Reese, Jevan Howden, Tia T. ThomasAbstractEthnopharmacological relevanceSmilax ornata Lem. is used in folklore medicine to treat rheumatoid arthritis and rheumatic pain. This particular claim has never been scientifically validated before in this plant species and hence, it forms the reason for this investigation.ObjectiveTo investigate whether the methanol and ethyl acetate extracts of Smilax ornata Lem. possess anti-inflammatory and analgesic properties in Sprague-Dawley rats.MethodsThe anti-i...
Source: Journal of Ethnopharmacology - May 5, 2019 Category: Drugs & Pharmacology Source Type: research

Antibacterial effects of extracts obtained from plants of Argentina: Bioguided isolation of compounds from the anti-infectious medicinal plant Lepechinia meyenii
ConclusionsThe results of this study contribute to validate the traditional antibacterial use of species native to Argentina, particularly of L. meyenii. The chemical structures of the compounds obtained may aid the design of antibacterial agents, especially those effective against MRSA.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 5, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca L Delile in Wistar rats
Publication date: Available online 2 May 2019Source: Journal of EthnopharmacologyAuthor(s): Michael O. Ugwah, Chinenye J. Ugwah-Oguejiofor, Emmanuel U. Etuk, Shaibu O. Bello, Adamu A. AlieroAbstractEthnopharmacological relevanceBalanites aegyptiaca L. Delile (Zygophyllaceae) is a perennial tree that is mostly found in Africa, south Asia and most desert environments. Decoctions of its stem barks are used in northern Nigeria for the treatment of ulcers and stomach issues. Other folkloric uses include treatment of wounds, malaria, dysentery, asthma, and fever.Aim of the study: The present study evaluated the antiulcer activit...
Source: Journal of Ethnopharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure mice through targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways
ConclusionsAll the data in this study suggested that YGY extract ameliorated the cognitive impairment of CRF mice, and this amelioration was related to up-regulating the CaMKIIα/CREB/BDNF and EPO/EPOR pathways.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Medicinal plants in homegardens of four ethnic groups in Thailand
ConclusionHomegardens are an important source of ethnomedicinal species and knowledge. These species are beneficial for treating acute and common ailments; they are easy to access and can be prepared by simple methods, which are suitable for treating disorders, such as infections or any digestive system ailments. Medicinal plants in homegardens have been important in improving health, at least, at the family level.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Origanum majorana L. extract exhibit positive cooperative effects on the main mechanisms involved in acute infectious diarrhea
Conclusionthe present results indicate that aqueous extract of Origanum majorana L. exhibit positive cooperative effects on the main mechanisms that are involved in acute infectious diarrhea.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy
Conclusions: The three effective fractions of Radix Isatidis have remarkable synergistic anti-RSV effects in vitro and in vivo, and total alkaloids and lignans show multi-target synergistic effects via the RIG-I and MDA5 signaling pathways.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Improvement of chemotherapy through reducing of cachexia by using Citrus unshiu peel extract
Conclusions; These findings confirm the safety and efficacy of CUPE on C26 adenocarcinoma bearing mice as pure and adjuvant therapy, the results of which might be used in further human studies as a valuable natural anticancer agent alone or in combination with chemotherapy. Also the results showed that simultaneous application of CUPE and Dox leads to significant reduction of cachexia from the Dox chemotherapy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Preparation, structural identification and intervention on immunodeficiency mice of enzymatic peptides from Mauremys mutica and Cuora trifasciata
ConclusionsTwo kinds of healthy turtle protein extracts and peptides had certain recovery effects on immune injury in mice. YPT peptides possessed the best effect on the recovery of immunodeficiency.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Different patterns in medicinal plant use along an elevational gradient in northern Peruvian Andes
Publication date: Available online 28 April 2019Source: Journal of EthnopharmacologyAuthor(s): Fernando Corroto, Oscar A. Gamarra Torres, Manuel J. MacíaAbstractEthnopharmacological relevanceThrough the study of mestizo people that share a common culture in a large geographic region and where traditional knowledge (TK) is still poorly documented, we compared medicinal plant use in the northern Andes of Peru.Aims of the study: (1) To compare patterns of the distribution of TK for a human group living between two ecoregions: high tropical montane forests vs. Low tropical montane forests; (2) to understand the TK at th...
Source: Journal of Ethnopharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Paris saponin VII extracted from trillium tschonoskii suppresses proliferation and induces apoptosis of human colorectal cancer cells
ConclusionOur results suggest that PSVII suppressed the activation of IL-6/STAT3 pathway, consequently suppressed the growth and proliferation and triggered the apoptosis of CRC cells. These findings indicate that PSⅦ might be an effective tumouristatic agent for the treatment of colorectal cancer.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Integrating strategies of chemistry, biochemistry and metabolomics for characterization of the medication principle of “treating cold/heat syndrome with hot/cold herbs”
ConclusionsThe medication principle was scientifically elucidated from perspective of material and energy metabolism. Moreover, this integrated novel strategy provides a feasible approach for future research of Chinese medicinal herb.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

In vivo anti-arthritic effect and repeated dose toxicity of standardized methanolic extracts of Buddleja cordata Kunth (Buddlejaceae) wild plant leaves and cell culture
ConclusionMethanolic extracts of Buddleja cordata wild and their cell cultures did not generated lethality after a daily administration for 28 days at 1 g/kg, but it was observed that both showed a lipid-lowering effect. Also at dose of 250 mg/kg both extracts exerted anti-edematous, protection against the oxidation of lipid and proteins, regulation on antioxidant enzymatic response, down-regulation on lymphocytes CD4+ producers of IL-1β and TNF-α, an increase in IL-10 levels, which caused a decrease in leukocyte infiltration in ganglionic tissue during experimental arthritis.Graphical abstract (Source: Jour...
Source: Journal of Ethnopharmacology - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Antitussive, expectorant, and anti-inflammatory effects of Adenophorae Radix powder in ICR mice
ConclusionThe results obtained in this study suggest that AR powder exerts dose-dependent, favorable antitussive, expectorant, and anti-inflammatory activities achieved through modulation of the activity of mast cells and respiratory mucous production. Therefore, AR powder may serve as a therapeutic agent in various respiratory disorders, especially those that occur as a result of environmental toxicants.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: An updated systematic review and meta-analysis
ConclusionThe low quality of evidence suggested that adjunctive use of A. membranaceus preparations in addition to conventional therapies may be effective and tolerated for short-term reduction of albuminuria, proteinuria, and serum creatinine in DKD patients. The findings should be considered with caution due to the lack of high-quality RCTs and significant heterogeneity and publication bias. Further RCTs are needed to confirm the long-term efficacy and safety of A. membranaceus preparations, especially of the oral form, in patient-important outcomes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and antioxidative effects of Dan-Lou tablets in the treatment of coronary heart disease revealed by metabolomics integrated with molecular mechanism studies
ConclusionThe mechanism of DLT in the treatment of CHD involves inhibiting the expression of EGFR and the activation of the MAPK signaling pathway by regulating glycerophospholipid metabolism (LPCs) and energy metabolism (linoleic acid and γ-linolenic acid). Therefore, inflammation-related (TNF-α, IL-6, MMP9) and oxidative stress-related (ox-LDL, MDA, SOD) indicators are affected, leading to the regulation of the oxidative stress state and anti-inflammatory effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective effects of an Acer tegmentosum Maxim extract through antioxidant activity and the regulation of autophagy
ConclusionTherefore, these results indicate that the AT extract has a hepatoprotective effect by increasing antioxidant activity and inducing autophagy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Antiproliferative potential and phenolic compounds of infusions and essential oil of chamomile cultivated with homeopathy
ConclusionsTherefore, cultivation with homeopathy does not induce a genotoxic effect in the use of infusions and essential oil of chamomile, favoring the sustainable cultivation and the safe use of this medicinal species when cultivated with homeopathy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Antisteatotic and antioxidant activities of Thymbra spicata L. extracts in hepatic and endothelial cells as in vitro models of non-alcoholic fatty liver disease
ConclusionsT. spicata extracts could be promising bioactive products to develop natural therapeutic agents or dietary supplements to treat NAFLD and obesity-related metabolic disease. Our findings suggest that while the ethanolic extract might be used in preventing endothelium dysfunction, the aqueous extract would act better as lipid-lowering agent.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Characterising and screening cyclooxygenase-2 inhibitors from Zi-shen pill via affinity ultrafiltration-ultra performance liquid chromatography-mass spectrometry
ConclusionThe results revealed that affinity ultrafiltration UPLC-MS could successfully screen out the potential COX-2 inhibitors from complex Chinese herbal formula ZSP extract, indicating that its therapeutic effect on BPH was partically based on the enzyme active ingredients. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

UPLC-QTOF/MS-based metabolomics analysis of plasma reveals an effect of Xue-Fu-Zhu-Yu capsules on blood-stasis syndrome in CHD rats
In this study, serum lipid, blood haemorheology and metabolomics analyses were performed to depict a complete profile of XFZY capsules for the treatment of CHD with BSS and to reveal the potential mechanism of the XFZY capsules.Materials and methodsThe rat model of CHD with BSS was performed by combining high-fat diet (HFD) treatment with a left anterior descending coronary artery (LAD) ligation. After four weeks of treatment with XFZY capsules or simvastatin pills, an echocardiography was implemented for a therapeutic evaluation. Blood samples and heart tissues were then collected for further analyses. A UPLC-QTOF/MS-base...
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Extracts derived from a traditional Chinese herbal formula triggers necroptosis in ectocervical Ect1/E6E7 cells through activation of RIP1 kinase
ConclusionsTaken together, YDJ preparation displays an effective ability of inducing necroptosis in cervical cancer cells through activation of RIP1 kinase. However, although the treatment efficacy and potential mechanisms of YDJ extract in vivo remain unclear and need further investigation, it is believed that YDJ extract has the great potential to be used as a starting point to develop more potent agent for treating or preventing cervical cancer and other proliferative diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Diuretic activity and neuropharmacological effects and of an ethanol extract from Senna septemtrionalis (Viv.) H.S. Irwin & Barneby (Fabaceae)
ConclusionThe diuretic effects of SSE involve the possible contribution of prostaglandins and nitric oxide. SSE showed moderate anxiolytic and anticonvulsant effects, whereas the participation of α2-adrenoceptors is probably associated in the antidepressant-like effects of SSE.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material
ConclusionConsistent with the traditional usage in Southern China, GPEO may serve as a promising potent external therapeutic agent for the treatment of chronic pain.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Calligonum comosum (Escanbil) extract exerts anti-angiogenic, anti-proliferative and anti-inflammatory effects on endometriotic lesions
ConclusionsOur findings show that Calligonum comosum targets multiple, fundamental processes in the pathogenesis of endometriosis, which may be beneficial for the treatment of this common gynecological disorder.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Antioxidant and anti-inflammatory effect of Asphodelus microcarpus methanolic extracts
Publication date: Available online 26 April 2019Source: Journal of EthnopharmacologyAuthor(s): Nozha Mayouf, Noureddine Charef, Soulef Saoudi, Abderrahmane Baghiani, Seddik Khennouf, Lekhmici ArrarAbstractEthnopharmacological relevanceAsphodelus microcarpus is an important medicinal plant belonging to family Liliaceae. This plant is used in traditional medicine to treat abscesses by local application of the powder; the roots are used against white spots, and specifically used for ear pain.Aim of the studyThe aim of the present study was to assess the in vitro antioxidant effects and the in vivo anti-inflammatory activity o...
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective activity of Verbena litoralis, Verbena montevidensis and their main iridoid, brasoside
ConclusionsOur results contribute towards validation of the traditional use of V. montevidensis e V. litoralis in the treatment of liver disorders.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Ultrahigh-performance liquid chromatography with tandem mass spectrometry for the determination of 10 alkaloids in beagle plasma after the oral administration of the three Coptidis rhizoma extracts
This study is the first to determine corydaline, dehydrocorydaline, tetrahydropalmatine, palmatine, magnoflorine, jatrorrhizine, berberine, worenine, berberrubine, and coptisine, which adopted an ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry, simultaneously.Materials and methodsChromatographic separation was performed within 8 min by using an Agilent SB-C18 column (150 mm × 2.1 mm, 1.8 μm) with gradient mobile phase consisting of 0.3% acetic acid water (v/v) and acetonitrile at a flow rate of 0.3 mL/min. Multiple reaction monitoring mode was used to dete...
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research

Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation
ConclusionsThis study provides scientific evidence substantiating the traditional use of C. indicum in the treatment of inflammatory diseases, including gout, which is induced by physiologically analogous cause to MSU-induced peritonitis.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 26, 2019 Category: Drugs & Pharmacology Source Type: research