Polygonum multiflorum Thunb. Extract Stimulates Melanogenesis by Induction of COX2 Expression through the Activation of p38 MAPK in B16F10 Mouse Melanoma Cells.
We examined the effects of PME on cell viability, cellular melanin content, and tyrosinase activity in B16F10 cells. The melanogenic mechanism of PME was explored using signaling inhibitors and examining the expression of melanogenic genes and signaling molecules by western blot and RT-qPCR analyses. PME did not exhibit any cytotoxicity in B16F10 cells compared to that in control cells. PME treatment significantly increased melanin production and tyrosinase activity. In addition, PME induced the expression of cyclooxygenase-2 (COX2) as well as that of melanogenic genes, such as microphthalmia-associated transcription facto...
Source: Evidence-based Complementary and Alternative Medicine - July 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology
Publication date: 28 October 2020Source: Journal of Ethnopharmacology, Volume 261Author(s): Xinyan Xue, Yunyun Quan, Lihong Gong, Xiaohong Gong, Yunxia Li (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 28, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance.
Abstract Total polysaccharide from Polygonum multiflorum (PS) and 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could relieve high-fat and high-sugar diet (HF-HSD) induced rats' insulin resistance (IR) by gut microbiota and host regulation. We found that PS and TSG significantly reversed the increase of fasting blood glucose and the decrease of glucose tolerance in HF-HSD induced IR rats. PS and TSG effectively reversed the imbalance of Firmicutes/Bacteroides caused by an HF-HSD, and significantly reduced the relative abundance of Proteobacteria. It also affected the functional genes of gut microbiot...
Source: International Journal of Biological Macromolecules - July 17, 2020 Category: Biochemistry Authors: Bi Q, Gu W, Meng F, Yang X, Zeng L, Liang L, Yang M, Zhang T, Yu J Tags: Int J Biol Macromol Source Type: research

Molecules, Vol. 25, Pages 3070: Otoprotective Effect of 2,3,4 ′,5-Tetrahydroxystilbene-2-O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells
Molecules, Vol. 25, Pages 3070: Otoprotective Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells Molecules doi: 10.3390/molecules25133070 Authors: Yu-Hsuan Wen Jia-Ni Lin Rong-Shuan Wu Szu-Hui Yu Chuan-Jen Hsu Guo-Fang Tseng Hung-Pin Wu Excessive levels of reactive oxygen species (ROS) lead to mitochondrial damage and apoptotic cell death in gentamicin-induced ototoxicity. 2,3,4’,5-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), a bioactive constituent, isolated from Polygonum multiflorum Thunb., ...
Source: Molecules - July 6, 2020 Category: Chemistry Authors: Yu-Hsuan Wen Jia-Ni Lin Rong-Shuan Wu Szu-Hui Yu Chuan-Jen Hsu Guo-Fang Tseng Hung-Pin Wu Tags: Article Source Type: research

New phenolic constituents obtained from Polygonum multiflorum
Publication date: Available online 2 July 2020Source: Chinese Herbal MedicinesAuthor(s): Jian-bo Yang, Hua Sun, Jie Ma, Yun-fei Song, Yue Liu, Qi Wang, Shuang-cheng Ma, Xian-long Cheng, Feng Wei (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 2, 2020 Category: Complementary Medicine Source Type: research

High effective extraction of selected anthraquinones from Polygonum multiflorum using ionic liquids with ultrasonic assistance
Publication date: 15 September 2020Source: Journal of Molecular Liquids, Volume 314Author(s): Ke Yuan, Shiyu Chen, Xuemei Chen, Shun Yao, Xuejiao Wang, Hang Song, Minghui Zhu (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - July 1, 2020 Category: Molecular Biology Source Type: research

2,3,5,4 ′-tetrahydroxystilbene-2-O-β-D-glucoside induces autophagy of liver by activating PI3K/Akt and Erk pathway in prediabetic rats
2,3,5,4 ′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is an active compound derived from Polygonum multiflorum Thunb., a Chinese Taoist herbal medicine, which exerts lipid lowering, anti-cancer, anti-aging, anti-... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 8, 2020 Category: Complementary Medicine Authors: Xuanbin Wang, Jing Zeng, Xiao Wang, Ju Li, Jin Chen, Ning Wang, Miao Zhang, Yibin Feng and Huailan Guo Tags: Research article Source Type: research

Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells
Dermal papilla cells (DPCs) play a key role in hair growth among the various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as anagen to telogen transition and play a p... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 12, 2020 Category: Complementary Medicine Authors: Jae Young Shin, Yun-Ho Choi, Jaeyoon Kim, Se Young Park, You Jin Nam, So Young Lee, Jeong Hoon Jeon, Mu Hyun Jin and Sanghwa Lee Tags: Research article Source Type: research

Molecules, Vol. 25, Pages 2278: Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties
umar B Kunnumakkara According to the World Health Organization (WHO), cancer is the second-highest cause of mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the disease, poor prognosis, cost of conventional therapies, and associated side-effects add more burden to patients, post-diagnosis. Therefore, the search for alternatives for the treatment of cancer that are safe, multi-targeted, effective, and cost-effective has compelled us to go back to ancient systems of medicine. Natural herbs and plant formulations are laden with a variety of phytochemicals. One such compound ...
Source: Molecules - May 12, 2020 Category: Chemistry Authors: Sahu Henamayee Kishore Banik Bethsebie Lalduhsaki Sailo Bano Shabnam Choudhary Harsha Satti Srilakshmi Naidu VGM Seung Ho Baek Kwang Seok Ahn Ajaikumar B Kunnumakkara Tags: Review Source Type: research

Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells.
Authors: Kim DU, Chung JY, Jin SC, Kim MH, Komakech R, Shim KS, Kim YG, Yang WM, Kang Y Abstract This present study evaluated the effects of processed P. multiflorum on osteogenesis using Sarcoma osteogenic (SaOS-2) cell lines and osteoclastogenesis of bone marrow-derived macrophage cells (BMM) and to elucidate differences in effect on the expression of bone-related proteins between commercially sold P. multiflorum and patented, in vitro-propagated Korea Institute of Oriental Medicine (KIOM) P. multiflorum. Raw P. multiflorum and P. multiflorum that were stir-baked and steamed in black bean juice were compared, and...
Source: Evidence-based Complementary and Alternative Medicine - May 10, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

2,3,5,4'-tetrahydroxystilbence-2-O- β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish.
2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. Biomed Pharmacother. 2020 May 05;127:110138 Authors: Wang C, Hu NH, Yu LY, Gong LH, Dai XY, Peng C, Li YX Abstract With the improvement of people's living standards and the change of dietary habits, Non-alcoholic fatty liver disease (NAFLD) has gradually become one of the liver diseases that endanger human health around the world. However, there are no particularly effective drugs for NAFLD in the current market. Therefore, new drug candidates which ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 5, 2020 Category: Drugs & Pharmacology Authors: Wang C, Hu NH, Yu LY, Gong LH, Dai XY, Peng C, Li YX Tags: Biomed Pharmacother Source Type: research

PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway.
In this study, we firstly detected the oxidative stress response related molecules in serum samples of TBI patients and a TBI mice model, and found that oxidative stress response was activated after TBI, and TSG would reduce this effect. We further noticed that inflammation related molecules presented a similar trend with oxidative stress response related molecules. These results indicated that inflammatory response and oxidative stress processes were both activated after TBI, and reduced after TSG treatment. We further detected that the apoptosis related proteins and anti-oxidative proteins were increased after TSG treatm...
Source: Folia Neuropathologica - April 29, 2020 Category: Pathology Authors: Cao Y, Chen Y, Wang F, Wang Y, Long J Tags: Folia Neuropathol Source Type: research

Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
In conclusion, these phenomena suggested that TSG prevented LPS/ATP and Aβ-induced inflammation via AMPK/PINK1/Parkin-dependent enhancement of mitophagy. We found the neuroprotective effect of TSG, suggesting it may be beneficial for AD prevention and treatment by suppressing the activation of inflammation. PMID: 32353422 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 27, 2020 Category: Drugs & Pharmacology Authors: Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L Tags: Biochem Pharmacol Source Type: research

[ASAP] Water-Assisted/Water-Accelerated Photoreaction of < italic toggle="yes" > trans < /italic > -2,3,4',5-Tetrahydroxystilbene-2- < italic toggle="yes" > O < /italic > - ß- < sc > d < /sc > -glucoside from the Roots of < italic toggle="yes" > Polygonum multiflorum < /italic >
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b04922 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - April 22, 2020 Category: Food Science Authors: Ni-Man Bao, Jin Dai, Ning-Ling Liao, Wen-Feng Ying, and Rong-Hua Zhao* Source Type: research

Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats
The incidence of insulin resistance (IR) has rapidly increased worldwide over the last 20  years, no perfect solution has yet been identified. Finding new therapeutic drugs will help improve this situation. As ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 5, 2020 Category: Complementary Medicine Authors: Wen Gu, Min Yang, Qian Bi, Lin-Xi Zeng, Xi Wang, Jin-Cai Dong, Feng-Jiao Li, Xing-Xin Yang, Jing-Ping Li and Jie Yu Tags: Research article Source Type: research

Effects of Different Processed Products of Polygonum multiflorum on the Liver.
Conclusion: The content of the main components in Radix Polygonum multiflorum can be affected by processing time; stilbene glycoside may be the main component leading to liver injury. The degree of liver injury caused by Radix Polygonum multiflorum is negatively correlated with processing time.Polygonum multiflorum and different processed products and their effects on hepatotoxicity were investigated. Polygonum multiflorum and different processed products and their effects on hepatotoxicity were investigated. PMID: 32215041 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 28, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population.
Abstract BACKGROUND: Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China. HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury (PM-DILI). However, little is known about the relationship between single-nucleotide polymorphisms (SNPs) and PM-DILI. AIM: To identify SNPs that indicate susceptibility to PM-DILI. METHODS: We conducted a systematic study enrolling 382 participants from four independent hospitals, including 73 PM-DILI patients, 118 patients with other drug-induced liver injury (other-DILI) and 191 healthy controls....
Source: World Journal of Gastroenterology : WJG - March 28, 2020 Category: Gastroenterology Authors: Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L, Wang SY, Liu XZ, Tan KA, Shi WW, Wang GQ, Hou FQ Tags: World J Gastroenterol Source Type: research

The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury
Acta Pharmacologica Sinica, Published online: 02 March 2020; doi:10.1038/s41401-020-0360-3The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - March 2, 2020 Category: Drugs & Pharmacology Authors: Tai Rao Ya-ting Liu Xiang-chang Zeng Chao-peng Li Dong-sheng Ou-Yang Source Type: research

The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury.
Abstract Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liver injury (PM-DILI) is considered to be immune-mediated idiosyncratic liver injury, but the role of immune response and the underlying mechanisms are not completely elucidated. Previous studies focused on the direct toxicity of PM-DILI by using animal models with intrinsic drug-induced liver ...
Source: Acta Pharmacologica Sinica - March 2, 2020 Category: Drugs & Pharmacology Authors: Rao T, Liu YT, Zeng XC, Li CP, Ou-Yang DS Tags: Acta Pharmacol Sin Source Type: research

A review on the extraction, purification, detection, and pharmacological effects of 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum multiflorum
Publication date: April 2020Source: Biomedicine & Pharmacotherapy, Volume 124Author(s): Jin Qian, Mingqi Hou, Xian Wu, Chuanying Dai, Jiaqiang Sun, Liuyi DongAbstract2,3,5,4,-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG) is the main active constituent of the traditional Chinese medicine, Polygonum multiflorum; it was discovered that the compound has various biological activities and medicinal value including anti-aging, antioxidative (via scavenging free radicals), antihypercholesterolemic, anti-atherosclerotic, anti-inflammatory, hepatoprotective, and anti-tumor effects. TSG aids in prevention and treatment of Alz...
Source: Biomedicine and Pharmacotherapy - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

[ASAP] Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of < italic toggle="yes" > Polygonum multiflorum < /italic >
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00777 (Source: Journal of Natural Products)
Source: Journal of Natural Products - January 16, 2020 Category: Biochemistry Authors: Thi-Thuy An Nguyen †?, Manh Tuan Ha‡?, Se-Eun Park§, Jae Sue Choi§, Byung Sun Min*‡, and Jeong Ah Kim*† Source Type: research

2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside alleviated the acute hepatotoxicity and DNA damage in diethylnitrosamine-contaminated mice
This study aimed at investigating the effect of TSG on diethylnitrosamine (DEN)-induced acute hepatotoxicity and DNA damage.Main methodsFifty male C57BL/6 mice were randomly divided into 5 groups (n = 10 each): control, DEN, DEN+TSG (low), DEN+TSG (high) and TSG (high) groups. DEN (100 mg/kg) was injected intraperitoneally (i.p.) alone or with TSG (30 or 60 mg/kg, i.p.) for 5 consecutive days.Key findingsTSG inhibited liver injury and inflammatory cell infiltration in DEN-treated mice. It also attenuated DEN-induced accumulation of reactive oxygen species (ROS), proinflammatory cytokines, and DNA damage. Moreover, ...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges
This study was aimed at reviewing the status of research on liver injury due to PM, including clinical characteristics, risk factors, material basis research and mechanism of action, with a view to understanding PM-induced hepatotoxicity, and taking reasonable and effective measures to prevent it. In short, quality control is still one of the major safety problems in TCM drug safety concerns. The model of safety monitoring and risk management of PM drugs is not yet developed. Indeed, the characteristics and risk factors associated with PM require both proper understanding and control of the risk by strengthening standardiz...
Source: Frontiers in Pharmacology - December 13, 2019 Category: Drugs & Pharmacology Source Type: research

Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum.
Abstract Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction. To date, identifying individuals at risk for IDILI remains challenging. This is a prospective study, where a nested case-control (1:5) design was adopted. For six patients who had abnormalities in liver function test after Polygonum multiflorum Thunb. (PM) ingestion (susceptible group), 30 patients with normal liver function were matched (tolerant group). Based on liquid chromatography-mass spectrometry, metabolomics analysis was done on serum samples prior to PM ingestion, to screen the differential me...
Source: Archives of Toxicology - October 19, 2019 Category: Toxicology Authors: Zhang L, Niu M, Wei AW, Tang JF, Tu C, Bai ZF, Zou ZS, Xiao XH, Liu YP, Wang JB Tags: Arch Toxicol Source Type: research

Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE−/− mice
ConclusionPMRP and TSG improved lipid accumulation and inflammation, and regulated the intestinal microbial imbalance in ApoE−/- mice. TSG exerted a preventive effect in the development and progression of AS.Graphical abstractInflammation Inhibition and Gut Microbiota Regulation of TSG on in ApoE−/- Mice, Fengjiao Li, Ting Zhang, Yanran He et al. JEP_112232. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 12, 2019 Category: Drugs & Pharmacology Source Type: research

Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum.
In this study, we elucidated the contribution of the two major compounds, emodin-8-O-β-D-glucoside (EG) and 2,3,5,4´-tetrahydroxyl diphenylethylene-2-O-glucoside (TSG), in PM-induced liver injury. 2. Based on LC-MS, the two concerned compounds were detected simultaneously in the sera of patients with PM-induced liver injury. In the lipopolysaccharide (LPS)-mediated inflammatory stress rat model, by the analysis of plasma biochemistry and liver histopathology, we observed that the solo treatment of EG, not TSG, could induce significant liver injury; and the combined administration of EG and TSG caused more severe...
Source: Xenobiotica - August 19, 2019 Category: Research Authors: Zhang L, Liu X, Tu C, Li C, Song D, Zhu J, Zhou Y, Wang X, Li R, Xiao X, Liu Y, Wang J Tags: Xenobiotica Source Type: research

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
In conclusion, these results indicated that emodin could induce apoptosis in an SREBP1-dependent and SREBP1-independent manner in hepatocellular carcinoma cells. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 25, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Polygonum Multiflorum Thunb on liver fatty acid content in aging mice induced by D-galactose
Polygonum Multiflorum Thunb(PMT) has multiple biological effects, such as anti-inflammatory, lipid-lowering, anti-aging and so on. Therefore, D-galactose-induced aging mice were used to study the effect of PMT on... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 1, 2019 Category: Lipidology Authors: Jiangquan Yang, Yuqi He, Jiayi Zou, Lin Xu, Fang Fan and Zhenglong Ge Tags: Research Source Type: research

Neuroprotection by 2,3,5,4 ʹ-tetrahydroxystilbene-2-O- & beta;-D-glucoside extracts from Polygonum multiflorum against cerebral ischemia/reperfusion injury through the 5-hydroxytryptamine/5-hydroxytryptamine receptor pathway
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - May 27, 2019 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum.
Abstract Five new trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG)-based stilbene glycoside oligomers (1-5) were isolated from the roots of Polygonum multiflorum. Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1, 2, 4, and 5 were established by quantum-chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1-5 were proposed using TSG as the key precursor. In addition, compounds 1 and 3 exhibited moderate inhibitory activities against NO production in LPS-stimulated RAW264.7 c...
Source: Chemistry and Biodiversity - May 20, 2019 Category: Biochemistry Authors: Li SG, Huang XJ, Zhong YL, Li MM, Li YL, Wang Y, Ye WC Tags: Chem Biodivers Source Type: research

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
Lifeng Han1,2†, Piao Wang1†, Yulan Wang2,3*, Qianyu Zhao1, Fang Zheng1, Zhiying Dou1, Wenzhi Yang1, Limin Hu1 and Caixiang Liu2* 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China 2CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan, China 3Singapore Phenome...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats
Can Tu, Qin He, Chun-Yu Li, Ming Niu, Zi-Xin Han, Fei-Lin Ge, Yuan-Yuan Zhou, Le Zhang, Xiao-Hui Wang, Jing-Xiao Zhu, Rui-Sheng Li, Hai-Bo Song, Xiao-He Xiao, Jia-Bo Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 5, 2019 Category: Drugs & Pharmacology Source Type: research

Characterization and identification of the chemical constituents of Polygonum multiflorum Thunb. by high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry
This study provides a meaningful basis for correcting some mistakes in previous studies, as well as further quality control and pharmacological and toxicological research. (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - March 27, 2019 Category: Drugs & Pharmacology Source Type: research

Attributes of Polygonum multiflorum to transfigure red biotechnology.
Abstract A vast array of plant-based compounds has enriched red biotechnology to serve the human health and food. A peculiar medicinal plant which was an element of traditional Chinese medicine for centuries as a liver and kidney tonic, for life longevity and hair blackening, is Polygonum multiflorum Thunb. (PM) which is popularly known as "He shou wu" or "Fo-ti" and is rich in chemical components like stilbenes, quinones, and flavonoids which have been used as anti-aging, anti-alopecia, anti-cancer, anti-oxidative, anti-bacterial, anti-hyperlipidemia, anti-atherosclerosis, and immunomodulating...
Source: Applied Microbiology and Biotechnology - March 20, 2019 Category: Microbiology Authors: Ho TT, Murthy HN, Dalawai D, Bhat MA, Paek KY, Park SY Tags: Appl Microbiol Biotechnol Source Type: research

Systematic Review of Published Data on Herb Induced Liver Injury
This study aims to determine the clinical features of herb induced liver injury (HILI) including its constituent ratio among liver injury case cohorts that included both HILI and drug induced liver injury (DILI).Materials and MethodsA systematic review was conducted using a literature search for DILI/HILI in seven electric databases including PubMed, Cochrane and Embase. We analyzed the DILI/HILI cases and clinical characteristics in terms of herbs, conventional drugs, concomitant, or others.ResultsThirty-one studies met the necessary criteria and included 9 prospective and 22 retrospective studies. Among total number of o...
Source: Journal of Ethnopharmacology - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Bioassay based screening for the antiplatelet aggregation quality markers of Polygonum multiflorum with UPLC and chemometrics
Publication date: Available online 9 January 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Chunyu Li, Can Tu, Yi Che, Mingyu Zhang, Bin Dong, Xiaowei Zhou, Yafei Shi, Guohui Li, Jiabo WangAbstractCurrently, an increasing number of human’s health is seriously affected by acute thrombotic events. In China, Polygonum multiflorum (PM) is commonly used to treat diseases associated with thrombosis. Our previous work showed that PM could inhibit platelet aggregation that play a key role in the pathogenesis of thrombosis. However, the constituents of PM are complicated and its quality control method...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Polygonumnolides A1-B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb.
Abstract The author would like to include conflict of interest statement and Grant Numbers (81773874 and 81703665) in the acknowledgement section of the online published article. The conflict of interest statement and acknowledgement section should read as. PMID: 30569421 [PubMed - as supplied by publisher] (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - December 19, 2018 Category: Drugs & Pharmacology Authors: Yang J, Yan Z, Ren J, Dai Z, Ma S, Wang A, Su Y Tags: Arch Pharm Res Source Type: research

Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine
ConclusionHSW treatment for 7days did not cause liver damage. HSW accelerated bile acid enterohepatic circulation and changed the composition of intestinal BAs, leding to the activation of Fxr-Fgf15 signal in intestines, and further inhibited the expression of Cyp7a1 in the liver.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
In conclusion, the current study showed the hepatoprotective activity of PME by regulating the redox state in liver injury through Nrf2 activation and controlling hepatic bile acid homeostasis in obstructive cholestasis, through bile acid transporter expression modulation. PMID: 30416531 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 14, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Tetrahydroxystilbene glucoside-induced relaxation of the superior mesenteric artery via both endothelium-dependent and endothelium-independent mechanisms
Publication date: Available online 25 October 2018Source: Microvascular ResearchAuthor(s): Min Jia, Xuan-Xuan Zhou, Qiaohong Qin, Fang Wang, Jie Li, Cang-Bao Xu, Siwang WangAbstractTetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate the arterial relaxation effect of TSG on rat super...
Source: Microvascular Research - October 25, 2018 Category: Biochemistry Source Type: research

Enhanced production of phenolic compounds in hairy root cultures of Polygonum multiflorum and its metabolite discrimination using HPLC and FT-IR methods.
In this study, HRCs of Polygonum multiflorum were established from leaf explants infected with Agrobacterium rhizogenes strain KCCM 11879. Over 60% of the explants showed hairy root induction after 21 days of cultivation on hormone-free MS (Murashige and Skoog Physiol Plant 15:473-479, 1962) medium; induced roots were confirmed by PCR using a rolC-specific primer. Of the six lines of HRCs selected for further analysis, line HR-01 performed best, producing a root biomass (105.2 g L-1 of FW, 9.7 g L-1 of DW), which is 10-fold higher than that of non-transgenic roots. The HR-01 line also showed a sign...
Source: Applied Microbiology and Biotechnology - September 14, 2018 Category: Microbiology Authors: Ho TT, Lee JD, Ahn MS, Kim SW, Park SY Tags: Appl Microbiol Biotechnol Source Type: research

Clinicopathological features of He Shou Wu ‐Induced Liver Injury: This Ancient Anti‐Aging Therapy Is Not Liver‐Friendly
Liver International,Volume 0, Issue ja, -Not available-. (Source: Liver International)
Source: Liver International - August 1, 2018 Category: Gastroenterology Authors: Yan Wang , Lan Wang , Romil Saxena , Aileen Wee , Ruiyuan Yang , Qiuju Tian , Jiping Zhang , Xinyan Zhao , Jidong Jia Source Type: research

The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O- β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo.
The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo. Int J Biol Macromol. 2018 Jul 29;: Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR Abstract 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (THSG) is a bioactive polyhydroxystilbene compound obtained from Polygonum multiflorum Thunb. Although it has broad therapeutic potential, the application of THSG is limited due to its poor stability in vitro, poor absorption in the intestine, and short...
Source: International Journal of Biological Macromolecules - July 29, 2018 Category: Biochemistry Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR Tags: Int J Biol Macromol Source Type: research

Heshouwu (Polygonum multiflorum Thunb.) ethanol extract suppresses pre-adipocytes differentiation in 3T3-L1 cells and adiposity in obese mice
This study investigated whether Heshouwu (Polygonum multiflorum Thunb.) root ethanol extract (PME) has anti-obesity activity using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. Treatment with PME (5 and 10 μg/mL) dose-dependently suppressed 3T3-L1 pre-adipocyte differentiation to adipocytes and cellular triglyceride contents. In addition, PME inhibited mRNA and protein expression of adipogenic transcription factors such as CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), which led to down-regulation of fatty acid synthase gene expres...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression
Inhibiting β-amyloid (Aβ)-induced microglial activation is proposed as an effective strategy for the treatment of Alzheimer’s disease. Tetrahydroxystilbene glycoside (TSG) is the main active ingredient of Polygonum multiflorum and has a wide range of biological properties, including antiinflammation. Here, we focused on the function and regulatory mechanism of TSG in Aβ-induced N9 and BV2 cells. The results showed that Aβ treatment induced the activation of microglia cells and the production of inflammatory molecules, including inducible nitric oxide synthase, nitric oxide, cyclooxygenase 2, and p...
Source: NeuroReport - June 7, 2018 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
In this study, we identified that p53, Caspase-3, Active Caspase-3, and Caspase-9 were obviously upregulated in the skin of human and mice with hair loss by western blot analysis. Depilated mice treated with TSG showed markedly hair regrowth. TUNEL+ cells were also reduced in mice with TSG. These changes were accompanied with inhibition of Fas, p53, Bax, Active Caspase-3, and Procaspase-9 activities. These results demonstrated that TSG exerts great hair regrowth effect on hair loss, which was probably mediated by inhibition of p53, Fas, and Bax induced apoptosis. PMID: 29808162 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 30, 2018 Category: Research Authors: Chen L, Duan H, Xie F, Gao Z, Wu X, Chen F, Wu W Tags: Biomed Res Int Source Type: research

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
Miao Zhang, Longfei Lin, Hongmei Lin, Changhai Qu, Lei Yan, Jian Ni (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 25, 2018 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 23, Pages 1115: Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
g-Zhen Zhao In commercial herbal markets, Polygoni Multiflori Radix (PMR, the tuberous roots of Polygonum multiflorum Thunb.), a commonly-used Chinese medicinal material, is divided into different grades based on morphological features of size and weight. While more weight and larger size command a higher price, there is no scientific data confirming that the more expensive roots are in fact of better quality. To assess the inherent quality of various grades and of various tissues in PMR and to find reliable morphological indicators of quality, a method combining laser microdissection (LMD) and ultra-performance liquid...
Source: Molecules - May 8, 2018 Category: Chemistry Authors: Li Liang Jun Xu Zhi-Tao Liang Xiao-Ping Dong Hu-Biao Chen Zhong-Zhen Zhao Tags: Article Source Type: research