Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum.
In this study, we elucidated the contribution of the two major compounds, emodin-8-O-β-D-glucoside (EG) and 2,3,5,4´-tetrahydroxyl diphenylethylene-2-O-glucoside (TSG), in PM-induced liver injury. 2. Based on LC-MS, the two concerned compounds were detected simultaneously in the sera of patients with PM-induced liver injury. In the lipopolysaccharide (LPS)-mediated inflammatory stress rat model, by the analysis of plasma biochemistry and liver histopathology, we observed that the solo treatment of EG, not TSG, could induce significant liver injury; and the combined administration of EG and TSG caused more severe...
Source: Xenobiotica - August 19, 2019 Category: Research Authors: Zhang L, Liu X, Tu C, Li C, Song D, Zhu J, Zhou Y, Wang X, Li R, Xiao X, Liu Y, Wang J Tags: Xenobiotica Source Type: research

Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells
In conclusion, these results indicated that emodin could induce apoptosis in an SREBP1-dependent and SREBP1-independent manner in hepatocellular carcinoma cells. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 25, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Polygonum Multiflorum Thunb on liver fatty acid content in aging mice induced by D-galactose
Polygonum Multiflorum Thunb(PMT) has multiple biological effects, such as anti-inflammatory, lipid-lowering, anti-aging and so on. Therefore, D-galactose-induced aging mice were used to study the effect of PMT on... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - June 1, 2019 Category: Lipidology Authors: Jiangquan Yang, Yuqi He, Jiayi Zou, Lin Xu, Fang Fan and Zhenglong Ge Tags: Research Source Type: research

Neuroprotection by 2,3,5,4 ʹ-tetrahydroxystilbene-2-O- & beta;-D-glucoside extracts from Polygonum multiflorum against cerebral ischemia/reperfusion injury through the 5-hydroxytryptamine/5-hydroxytryptamine receptor pathway
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - May 27, 2019 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum.
Abstract Five new trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG)-based stilbene glycoside oligomers (1-5) were isolated from the roots of Polygonum multiflorum. Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1, 2, 4, and 5 were established by quantum-chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1-5 were proposed using TSG as the key precursor. In addition, compounds 1 and 3 exhibited moderate inhibitory activities against NO production in LPS-stimulated RAW264.7 c...
Source: Chemistry and Biodiversity - May 20, 2019 Category: Biochemistry Authors: Li SG, Huang XJ, Zhong YL, Li MM, Li YL, Wang Y, Ye WC Tags: Chem Biodivers Source Type: research

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
Lifeng Han1,2†, Piao Wang1†, Yulan Wang2,3*, Qianyu Zhao1, Fang Zheng1, Zhiying Dou1, Wenzhi Yang1, Limin Hu1 and Caixiang Liu2* 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China 2CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan, China 3Singapore Phenome...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats
Can Tu, Qin He, Chun-Yu Li, Ming Niu, Zi-Xin Han, Fei-Lin Ge, Yuan-Yuan Zhou, Le Zhang, Xiao-Hui Wang, Jing-Xiao Zhu, Rui-Sheng Li, Hai-Bo Song, Xiao-He Xiao, Jia-Bo Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 5, 2019 Category: Drugs & Pharmacology Source Type: research

Characterization and identification of the chemical constituents of Polygonum multiflorum Thunb. by high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry
This study provides a meaningful basis for correcting some mistakes in previous studies, as well as further quality control and pharmacological and toxicological research. (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - March 27, 2019 Category: Drugs & Pharmacology Source Type: research

Attributes of Polygonum multiflorum to transfigure red biotechnology.
Abstract A vast array of plant-based compounds has enriched red biotechnology to serve the human health and food. A peculiar medicinal plant which was an element of traditional Chinese medicine for centuries as a liver and kidney tonic, for life longevity and hair blackening, is Polygonum multiflorum Thunb. (PM) which is popularly known as "He shou wu" or "Fo-ti" and is rich in chemical components like stilbenes, quinones, and flavonoids which have been used as anti-aging, anti-alopecia, anti-cancer, anti-oxidative, anti-bacterial, anti-hyperlipidemia, anti-atherosclerosis, and immunomodulating...
Source: Applied Microbiology and Biotechnology - March 20, 2019 Category: Microbiology Authors: Ho TT, Murthy HN, Dalawai D, Bhat MA, Paek KY, Park SY Tags: Appl Microbiol Biotechnol Source Type: research

Systematic Review of Published Data on Herb Induced Liver Injury
This study aims to determine the clinical features of herb induced liver injury (HILI) including its constituent ratio among liver injury case cohorts that included both HILI and drug induced liver injury (DILI).Materials and MethodsA systematic review was conducted using a literature search for DILI/HILI in seven electric databases including PubMed, Cochrane and Embase. We analyzed the DILI/HILI cases and clinical characteristics in terms of herbs, conventional drugs, concomitant, or others.ResultsThirty-one studies met the necessary criteria and included 9 prospective and 22 retrospective studies. Among total number of o...
Source: Journal of Ethnopharmacology - January 11, 2019 Category: Drugs & Pharmacology Source Type: research

Bioassay based screening for the antiplatelet aggregation quality markers of Polygonum multiflorum with UPLC and chemometrics
Publication date: Available online 9 January 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Chunyu Li, Can Tu, Yi Che, Mingyu Zhang, Bin Dong, Xiaowei Zhou, Yafei Shi, Guohui Li, Jiabo WangAbstractCurrently, an increasing number of human’s health is seriously affected by acute thrombotic events. In China, Polygonum multiflorum (PM) is commonly used to treat diseases associated with thrombosis. Our previous work showed that PM could inhibit platelet aggregation that play a key role in the pathogenesis of thrombosis. However, the constituents of PM are complicated and its quality control method...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Polygonumnolides A1-B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb.
Abstract The author would like to include conflict of interest statement and Grant Numbers (81773874 and 81703665) in the acknowledgement section of the online published article. The conflict of interest statement and acknowledgement section should read as. PMID: 30569421 [PubMed - as supplied by publisher] (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - December 19, 2018 Category: Drugs & Pharmacology Authors: Yang J, Yan Z, Ren J, Dai Z, Ma S, Wang A, Su Y Tags: Arch Pharm Res Source Type: research

Polygonum multiflorum Thunb suppress bile acid synthesis by activating Fxr-Fgf15 signaling in the intestine
ConclusionHSW treatment for 7days did not cause liver damage. HSW accelerated bile acid enterohepatic circulation and changed the composition of intestinal BAs, leding to the activation of Fxr-Fgf15 signal in intestines, and further inhibited the expression of Cyp7a1 in the liver.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
In conclusion, the current study showed the hepatoprotective activity of PME by regulating the redox state in liver injury through Nrf2 activation and controlling hepatic bile acid homeostasis in obstructive cholestasis, through bile acid transporter expression modulation. PMID: 30416531 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 14, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund as two sides of the same biological coin
ConclusionRPM exerted a complicated non-linear manner in healthy recipients, switching between hepatoxicity and hepatoprotection dependent on the dosage and status of the body.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Tetrahydroxystilbene glucoside-induced relaxation of the superior mesenteric artery via both endothelium-dependent and endothelium-independent mechanisms
Publication date: Available online 25 October 2018Source: Microvascular ResearchAuthor(s): Min Jia, Xuan-Xuan Zhou, Qiaohong Qin, Fang Wang, Jie Li, Cang-Bao Xu, Siwang WangAbstractTetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The aim of the present study was to use in vivo and in vitro models to investigate the arterial relaxation effect of TSG on rat super...
Source: Microvascular Research - October 25, 2018 Category: Biochemistry Source Type: research

Enhanced production of phenolic compounds in hairy root cultures of Polygonum multiflorum and its metabolite discrimination using HPLC and FT-IR methods.
In this study, HRCs of Polygonum multiflorum were established from leaf explants infected with Agrobacterium rhizogenes strain KCCM 11879. Over 60% of the explants showed hairy root induction after 21 days of cultivation on hormone-free MS (Murashige and Skoog Physiol Plant 15:473-479, 1962) medium; induced roots were confirmed by PCR using a rolC-specific primer. Of the six lines of HRCs selected for further analysis, line HR-01 performed best, producing a root biomass (105.2 g L-1 of FW, 9.7 g L-1 of DW), which is 10-fold higher than that of non-transgenic roots. The HR-01 line also showed a sign...
Source: Applied Microbiology and Biotechnology - September 14, 2018 Category: Microbiology Authors: Ho TT, Lee JD, Ahn MS, Kim SW, Park SY Tags: Appl Microbiol Biotechnol Source Type: research

Clinicopathological features of He Shou Wu ‐Induced Liver Injury: This Ancient Anti‐Aging Therapy Is Not Liver‐Friendly
Liver International,Volume 0, Issue ja, -Not available-. (Source: Liver International)
Source: Liver International - August 1, 2018 Category: Gastroenterology Authors: Yan Wang , Lan Wang , Romil Saxena , Aileen Wee , Ruiyuan Yang , Qiuju Tian , Jiping Zhang , Xinyan Zhao , Jidong Jia Source Type: research

The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O- β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo.
The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo. Int J Biol Macromol. 2018 Jul 29;: Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR Abstract 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (THSG) is a bioactive polyhydroxystilbene compound obtained from Polygonum multiflorum Thunb. Although it has broad therapeutic potential, the application of THSG is limited due to its poor stability in vitro, poor absorption in the intestine, and short...
Source: International Journal of Biological Macromolecules - July 29, 2018 Category: Biochemistry Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR Tags: Int J Biol Macromol Source Type: research

Heshouwu (Polygonum multiflorum Thunb.) ethanol extract suppresses pre-adipocytes differentiation in 3T3-L1 cells and adiposity in obese mice
This study investigated whether Heshouwu (Polygonum multiflorum Thunb.) root ethanol extract (PME) has anti-obesity activity using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. Treatment with PME (5 and 10 μg/mL) dose-dependently suppressed 3T3-L1 pre-adipocyte differentiation to adipocytes and cellular triglyceride contents. In addition, PME inhibited mRNA and protein expression of adipogenic transcription factors such as CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), which led to down-regulation of fatty acid synthase gene expres...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research

Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression
Inhibiting β-amyloid (Aβ)-induced microglial activation is proposed as an effective strategy for the treatment of Alzheimer’s disease. Tetrahydroxystilbene glycoside (TSG) is the main active ingredient of Polygonum multiflorum and has a wide range of biological properties, including antiinflammation. Here, we focused on the function and regulatory mechanism of TSG in Aβ-induced N9 and BV2 cells. The results showed that Aβ treatment induced the activation of microglia cells and the production of inflammatory molecules, including inducible nitric oxide synthase, nitric oxide, cyclooxygenase 2, and p...
Source: NeuroReport - June 7, 2018 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
In this study, we identified that p53, Caspase-3, Active Caspase-3, and Caspase-9 were obviously upregulated in the skin of human and mice with hair loss by western blot analysis. Depilated mice treated with TSG showed markedly hair regrowth. TUNEL+ cells were also reduced in mice with TSG. These changes were accompanied with inhibition of Fas, p53, Bax, Active Caspase-3, and Procaspase-9 activities. These results demonstrated that TSG exerts great hair regrowth effect on hair loss, which was probably mediated by inhibition of p53, Fas, and Bax induced apoptosis. PMID: 29808162 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 30, 2018 Category: Research Authors: Chen L, Duan H, Xie F, Gao Z, Wu X, Chen F, Wu W Tags: Biomed Res Int Source Type: research

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
Miao Zhang, Longfei Lin, Hongmei Lin, Changhai Qu, Lei Yan, Jian Ni (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 25, 2018 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 23, Pages 1115: Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
g-Zhen Zhao In commercial herbal markets, Polygoni Multiflori Radix (PMR, the tuberous roots of Polygonum multiflorum Thunb.), a commonly-used Chinese medicinal material, is divided into different grades based on morphological features of size and weight. While more weight and larger size command a higher price, there is no scientific data confirming that the more expensive roots are in fact of better quality. To assess the inherent quality of various grades and of various tissues in PMR and to find reliable morphological indicators of quality, a method combining laser microdissection (LMD) and ultra-performance liquid...
Source: Molecules - May 8, 2018 Category: Chemistry Authors: Li Liang Jun Xu Zhi-Tao Liang Xiao-Ping Dong Hu-Biao Chen Zhong-Zhen Zhao Tags: Article Source Type: research

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
Yue Liu, Qi Wang, Jianbo Yang, Xiaohan Guo, Wenxi Liu, Shuangcheng Ma, Shaoping Li (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 16, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Polygonum multiflorum on ischemic stroke rat model analysed by 1H NMR metabolic profiling
This study aims to explore the protective effect of HSW on ischemic stroke rat model and to elucidate the underlying mechanisms. The mortality rate, neurological deficit, cerebral infarct size, histopathology, immunohistochemistry, biochemical parameters, quantitative real-time polymerase chain reaction and western blotting were used to access the treatment effects of HSW on ischemic stroke. Proton nuclear magnetic resonance (1H NMR) based metabolomics analysis disclosed that HSW could relieve stroke rats suffering from the ischemia/reperfusion injury by ameliorating the disturbed energy and amino acids metabolisms, allevi...
Source: Journal of Pharmaceutical and Biomedical Analysis - April 4, 2018 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 23, Pages 571: In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4 ′-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum
In this study, the anti-osteoarthritis (OA) effects of THSG were explored using in vitro and in vivo models. THSG inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production and inducible NO synthase (iNOS) and cyclooxygenase-2 expressions by lipopolysaccharide-stimulated RAW 264.7 cells. On the other hand, THSG inhibited PGE2 production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1β-stimulated primary rat chondrocytes. Through a mono-iodoacetate-induced rat OA model assay, THSG reduced paw edema and improved the weight-bearing distribution. Therefore, THSG has anti-inflammatory activity...
Source: Molecules - March 3, 2018 Category: Chemistry Authors: Po-Wei Tsai Yi-Hui Lee Lih-Geeng Chen Chia-Jung Lee Ching-Chiung Wang Tags: Article Source Type: research

Structure characterization of two functional polysaccharides from Polygonum multiflorum and its immunomodulatory.
Abstract Two purified polysaccharides named WPMP-1 and WPMP-2 were obtained from Polygonum multiflorum with an average molecular weight of 2.04 kDa and 92.13 kDa, respectively. Structural characterization revealed that WPMP-1was supposed to be a glucan composed of 1,4-linked α-d-Glcp, 1,4,6-linked α-d-Glcp, and terminal α-d-Glcp. WPMP-2 contained a complex branched structre formed by 1,2-linked α-d-Rhap, 1,2,4-linked α-d-Rhap, 1,3,5-linked α-l-Ara, 1,5- linked α-l-Araf, terminal α-l-Araf, 1,4-linked β-d-Galp, 1,4-linked α-d-GalpA, and 4-linked α-...
Source: International Journal of Biological Macromolecules - February 19, 2018 Category: Biochemistry Authors: Zhang Q, Xu Y, Lv J, Cheng M, Wu Y, Cao K, Zhang X, Mou X, Fan Q Tags: Int J Biol Macromol Source Type: research

New utilization of Polygonum multiflorum polysaccharide as macromolecular carrier of 5-fluorouracil for controlled release and immunoprotection.
Abstract WPMP-2 is an acid polysaccharide isolated from Polygonum multiflorum, which demonstrated excellent immunomodulatory activity. In order to reduce immunosuppression of 5-fluorouracil (5-Fu), WPMP-2 was utilized as a macromolecular carrier to conjugate the 5-Fu derivatives 5-fluorouracil-1-acetic acid (5-FUAC) through ester bond. The conjugate showed controlled drug release behaviour in vitro at 37 °C in phosphate buffer (pH 7.4), and only 5-FUAC was detected in the media. The cytotoxicity test in vitro showed that the conjugate exhibited different cytotoxicity to HepG-2 and HT-29 cells. In addition,...
Source: International Journal of Biological Macromolecules - February 9, 2018 Category: Biochemistry Authors: Zhang Q, Xu Y, Lv J, Cheng M, Wu Y, Cao K, Zhang X, Mou X, Fan Q Tags: Int J Biol Macromol Source Type: research

Management of IFN-beta-induced flu-like symptoms with Chinese herbal medicine in a patient with multiple sclerosis: A case report.
CONCLUSIONS: IFNβ-1a injections will damage qi and cause blood stasis in MS patients, thereby causing various side effects and weakening the body's immune system. Bu-Zhong-Yi-Qi-Tang, associated with Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica dahurica and Polygonum multiflorum Thunb., is an effective prescription to ameliorate such symptoms and signs in patients with MS. PMID: 29458918 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - February 1, 2018 Category: Complementary Medicine Authors: Lee LW, Lin HJ, Huang ST Tags: Complement Ther Med Source Type: research

Multiflorumisides A –G, Dimeric Stilbene Glucosides with Rare Coupling Patterns from the Roots of Polygonum multiflorum
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.7b00540 (Source: Journal of Natural Products)
Source: Journal of Natural Products - January 23, 2018 Category: Biochemistry Authors: Shuo-Guo Li, Xiao-Jun Huang, Man-Mei Li, Qing Liu, Hui Liu, Ying Wang and Wen-Cai Ye Source Type: research

Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo.
Abstract Polygonum multiflorum Thunb. has been used widely in East Asia in treatment of diseases associated with aging. However, there are many reports referred to the toxicity of P. multiflorum, especially for liver adverse reactions. The toxicity of it is caused by over dosage or by the herb itself remains unclear. The aim of this study was to study the toxicity of different extractions, components and constituents of P. multiflorum, which were assessed in zebrafish embryos. Firstly, the difference of extracting solvent to the toxicity of P. multiflorum was researched to probe the influence of usages to the safe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2018 Category: Drugs & Pharmacology Authors: Yang JB, Li WF, Liu Y, Wang Q, Cheng XL, Wei F, Wang AG, Jin HT, Ma SC Tags: Biomed Pharmacother Source Type: research

Improvement of biosynthesis and accumulation of bioactive compounds by elicitation in adventitious root cultures of Polygonum multiflorum.
We examined the effects of abiotic (methyl jasmonate [MeJA] and salicylic acid [SA]) and biotic (yeast extract and chitosan) elicitors for improvement of bioactive compounds production on adventitious root cultures in Polygonum multiflorum. The application of yeast extract resulted in significantly (p ≤ 0.05) higher dry root biomass (9.98 g/L) and relative growth rate versus the control. Cultures treated with abiotic elicitors showed higher percentage of dry weight than the other samples. Low concentrations of all elicitors (50 μM MeJA and SA, and 50 mg/L yeast extract) improved secondary...
Source: Applied Microbiology and Biotechnology - November 14, 2017 Category: Microbiology Authors: Ho TT, Lee JD, Jeong CS, Paek KY, Park SY Tags: Appl Microbiol Biotechnol Source Type: research

The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo.
In this study, the effects and relevant mechanisms of lipid-regulation by raw Polygonum multiflorum (RPM) were investigated. The results indicated that the basal plasma lipids, such as low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), were significantly decreased in RPM treatment groups compared with the model group, especially in the RPM high dose group. The key enzymes involved in lipid metabolism, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) in plasma were generally reduced after oral administration, which was consi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Xian Z, Liu Y, Xu W, Duan F, Guo Z, Xiao H Tags: Biol Pharm Bull Source Type: research

Stilbene Glucoside, a Putative Sleep Promoting Constituent from Polygonum multiflorum Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase.
Abstract Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented. Electroencephalogram (EEG) and electromyogram (EMG) electrodes were implanted to determine sle...
Source: Chemical and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Wei Q, Ta G, He W, Wang W, Wu Q Tags: Chem Pharm Bull (Tokyo) Source Type: research

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
Yun-Xia Li, Xiao-Hong Gong, Mei-Chen Liu, Cheng Peng, Peng Li, Yi-Tao Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 1, 2017 Category: Drugs & Pharmacology Source Type: research

Application of iTRAQ-Based Quantitative Proteomics Approach to Identify Deregulated Proteins Associated with Liver Toxicity Induced by Polygonum Multiflorum in Rats
Conclusion: This iTRAQ proteomics study revealed that the hepatotoxicity induced by PM is primarily related to the oxidative phosphorylation pathways. NADH dehydrogenase family proteins andSlc16a2 could be potential biomarkers of hepatotoxicity resulting from PM.Cell Physiol Biochem 2017;43:2102 –2116 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 25, 2017 Category: Cytology Source Type: research

2,3,5,4 ‑tetrahydroxy diphenylethylene‑2‑O‑glucoside inhibits the adhesion and invasion of A549 human lung cancer cells.
In conclusion, THSG effectively suppressed the adhesion and invasion of human lung cancer cells potentially by inhibiting the expression of adhesion and invasion‑related genes. PMID: 28990072 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 12, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity.
In conclusion, TSG, as a major component of P. multiflorum Thunb. exhibited an osteogenic promoting activity in MSCs and in zebrafish. The results provided scientific evidence to support the potential use of TSG for protecting the bone in degenerative diseases, such as OP. PMID: 28966672 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - October 4, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

Therapeutic applications of resveratrol and its derivatives on periodontitis
Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time‐consuming. Recently, herbal medicines have been considered for use in treating inflammation‐related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti‐inflammatory properties and other medical benefits. Here, we highlight the importance of r...
Source: Annals of the New York Academy of Sciences - August 30, 2017 Category: Science Authors: Yu ‐Tang Chin, Guei‐Yun Cheng, Ya‐Jung Shih, Chi‐Yu Lin, Shan‐Jen Lin, Hsuan‐Yu Lai, Jacqueline Whang‐Peng, Hsien‐Chung Chiu, Sheng‐Yang Lee, Earl Fu, Heng‐Yuan Tang, Hung‐Yun Lin, Leroy F Liu Tags: REVIEW Source Type: research

Application of HPLC-LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats.
Abstract The root of Polygonum multiflora (PM) is an important Chinese herbal medicine for treatment of various diseases. Extensive pharmacological studies have been conducted and demonstrated that it shows a wide range of bioactivities. Meanwhile, considerable amount of hepatotoxicity cases due to oral administration of PM has been reported and attracted great attention. However, The limited knowledge regarding the metabolism of PM restricts the deeper studies on pharmacological/toxic mechanism and therapeutic material basis. The present study was aimed to develop a high-performance liquid chromatography coupled ...
Source: Biomedical Chromatography : BMC - August 17, 2017 Category: Biomedical Science Authors: Zhang J, Wang T, Ren Z, Gong L, Huang J, Bai J, Qiu X, Xu W Tags: Biomed Chromatogr Source Type: research

Erratum: "Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma".
Erratum: "Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma". Am J Chin Med. 2017;45(5):1125 Authors: Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R PMID: 28760043 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 3, 2017 Category: Complementary Medicine Authors: Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R Tags: Am J Chin Med Source Type: research

Polygonumnolides A1-B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb.
Abstract Seven new dianthrone glycosides, named polygonumnolides A1-B3 (1-7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1-4 showed moderate cytotoxicity. PMID: 28681348 [PubMed - as supplied by publisher] (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - July 5, 2017 Category: Drugs & Pharmacology Authors: Yang J, Yan Z, Ren J, Dai Z, Ma S, Wang A, Su Y Tags: Arch Pharm Res Source Type: research

Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR- γ.
In this study, we investigated the molecular basis of PM-induced liver injury in a rat model of IDILI based on a non-hepatotoxic dose of LPS. SD rats were orally administered 3 potentially hepatotoxic compounds of PM: cis-stilbene glucoside (cis-SG, 50 mg/kg), trans-SG (50 mg/kg) or emodin (5 mg/kg), followed by injection of LPS (2.8 mg/kg, iv). Serum and liver histology were evaluated 7 h after LPS injection. Among the 3 compounds tested, cis-SG, but not emodin or trans-SG, induced severe liver injury in rats when combined with LPS. The levels of AST and ALT in plasma and inflammatory cytokines in both plasma and liver ti...
Source: Acta Pharmacologica Sinica - June 26, 2017 Category: Drugs & Pharmacology Authors: Meng YK, Li CY, Li RY, He LZ, Cui HR, Yin P, Zhang CE, Li PY, Sang XX, Wang Y, Niu M, Zhang YM, Guo YM, Sun R, Wang JB, Bai ZF, Xiao XH Tags: Acta Pharmacol Sin Source Type: research

Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1.
The objective of this study is to investigate the relationship between the hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root of Polygonum multiflorum Thunb., He Shou Wu) and the activity of CYP1A2 or CYP2E1 in the rat liver. Levels of rat serum transaminases ALT and AST were not altered but the activity of CYP1A2 or CYP2E1 in the rat liver was significantly inhibited after oral administration of aqueous extract of PMR under the experimental dosage. However, levels of ALT and AST were significantly increased and the activity of CYP1A2 or CYP2E1 was significantly decreased after injection of specific inhibitor f...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
Longfei Lin, Hui Li, Hongmei Lin, Miao Zhang, Changhai Qu, Lei Yan, Xingbin Yin, Jian Ni (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 20, 2017 Category: Drugs & Pharmacology Source Type: research

Sequential extraction and separation using ionic liquids for stilbene glycoside and anthraquinones in Polygonum multiflorum
Publication date: September 2017 Source:Journal of Molecular Liquids, Volume 241 Author(s): Xueting Feng, Hang Song, Bing Dong, Yang Yang, Shun Yao In recent years, ionic liquids (ILs) have received more attentions in green extraction and separation process as a kind of novel environment-friendly solvent, and their application in the field of natural products needs to be extended. In this paper, a new method of the sequential extraction for stilbene glycoside and anthraquinones from Polygonum multiflorum was developed for the first time and different ionic liquids was used and compared. It was found two benzothiazolium IL...
Source: Journal of Molecular Liquids - June 7, 2017 Category: Molecular Biology Source Type: research

Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus.
CONCLUSION: In conclusion, TSG produces antidepressant-like effects in mice via enhancement of the hippocampal BDNF system. PMID: 28547794 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 25, 2017 Category: Neuroscience Authors: Wang H, Zhao Y, Wang YJ, Song L, Wang JL, Huang C, Zhang W, Jiang B Tags: CNS Neurosci Ther Source Type: research