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 In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research

 In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171 (Sourc...
Source: World Journal of Gastroenterology : WJG - January 23, 2023 Category: Gastroenterology Authors: Li-Ping Yu Yan-Juan Li Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang Source Type: research

Emodin in cardiovascular disease: The role and therapeutic potential
Emodin is a natural anthraquinone derivative extracted from Chinese herbs, such as Rheum palmatum L, Polygonum cuspidatum, and Polygonum multiflorum. It is now also a commonly used clinical drug and is listed in the Chinese Pharmacopoeia. Emodin has a wide range of pharmacological properties, including anticancer, antiinflammatory, antioxidant, and antibacterial effects. Many in vivo and in vitro experiments have demonstrated that emodin has potent anticardiovascular activity. Emodin exerts different mechanisms of action in different types of cardiovascular diseases, including its involvement in pathological processes, suc...
Source: Frontiers in Pharmacology - December 23, 2022 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 28, Pages 25: Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking
This study not only found that the HEMs of PMT were TSG and EG, but also clarified that PMT might affect purine metabolism to induce liver injury, which contributed to our understanding of the underlying mechanisms of PMT hepatotoxicity. (Source: Molecules)
Source: Molecules - December 21, 2022 Category: Chemistry Authors: Yinhuan Zhang Lirong Liu Menghan Feng Hao Wu Yihang Dai Zhixin Jia Cong Fang Mingyan Liu Xiaoning Yan Meixia Zhu Beibei Huang Biqiong Qu Hongbin Xiao Tags: Article Source Type: research

Molecules, Vol. 27, Pages 8592: A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to Polygonum multiflorum
g Li Hongbin Xiao Polygonum multiflorum (PM) has been used as a tonic and anti-aging remedy for centuries in Asian countries. However, its application in the clinic has been hindered by its potential to cause liver injury and the lack of investigations into this mechanism. Here, we established a strategy using a network pharmacological technique combined with integrated pharmacokinetics to provide an applicable approach for addressing this issue. A fast and sensitive HPLC-QQQ-MS method was developed for the simultaneous quantification of five effective compounds (trans-2,3,5,4&prime;-tetrahydroxystilbene-2-O-...
Source: Molecules - December 6, 2022 Category: Chemistry Authors: Zhixin Jia Lirong Liu Cong Fang Mingxia Pan Shiyu Cong Zhonghui Guo Xiaoqin Yang Jie Liu Yueting Li Hongbin Xiao Tags: Article Source Type: research

2,3,5,4'-Tetrahydroxy stilbene-2- Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo
Chem Biol Interact. 2022 Nov 1:110234. doi: 10.1016/j.cbi.2022.110234. Online ahead of print.ABSTRACT2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside (TSG) and emodin (EMD) are two main components of Polygonum multiflorum Thunb. (PMT). Its root is widely used as herbal medicine and supplement. However, PMT-induced liver injury has drawn increasing attention. The purpose of this study was to investigate the interaction of TSG with EMD in the aspects of enzymology, pharmacokinetics, and hepatotoxicity. Co-administration with TSG increased internal exposure of EMD, EMD-derived hepatic protein adduction, and EMD-induced live...
Source: Chemico-Biological Interactions - November 4, 2022 Category: Molecular Biology Authors: Xu Wang Lingwen Dong Guode Zhao Weiwei Li Ying Peng Jiang Zheng Source Type: research