The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O- β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo.
The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo.
Int J Biol Macromol. 2018 Jul 29;:
Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR
Abstract
2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (THSG) is a bioactive polyhydroxystilbene compound obtained from Polygonum multiflorum Thunb. Although it has broad therapeutic potential, the application of THSG is limited due to its poor stability in vitro, poor absorption in the intesti...
Source: International Journal of Biological Macromolecules - July 29, 2018 Category: Biochemistry Authors: Sun LL, Wang M, Zhang HJ, You GJ, Liu YN, Ren XL, Deng YR Tags: Int J Biol Macromol Source Type: research
Heshouwu (Polygonum multiflorum Thunb.) ethanol extract suppresses pre-adipocytes differentiation in 3T3-L1 cells and adiposity in obese mice
This study investigated whether Heshouwu (Polygonum multiflorum Thunb.) root ethanol extract (PME) has anti-obesity activity using 3T3-L1 cells and high-fat diet (HFD)-induced obese mice. Treatment with PME (5 and 10 μg/mL) dose-dependently suppressed 3T3-L1 pre-adipocyte differentiation to adipocytes and cellular triglyceride contents. In addition, PME inhibited mRNA and protein expression of adipogenic transcription factors such as CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), which led to down-regulation of fatty acid synthase gene expression. After feeding mi...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research
Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression
Inhibiting β-amyloid (Aβ)-induced microglial activation is proposed as an effective strategy for the treatment of Alzheimer’s disease. Tetrahydroxystilbene glycoside (TSG) is the main active ingredient of Polygonum multiflorum and has a wide range of biological properties, including antiinflammation. Here, we focused on the function and regulatory mechanism of TSG in Aβ-induced N9 and BV2 cells. The results showed that Aβ treatment induced the activation of microglia cells and the production of inflammatory molecules, including inducible nitric oxide synthase, nitric oxide, cyclooxygenase 2, and prostaglandin E2, whi...
Source: NeuroReport - June 7, 2018 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
In this study, we identified that p53, Caspase-3, Active Caspase-3, and Caspase-9 were obviously upregulated in the skin of human and mice with hair loss by western blot analysis. Depilated mice treated with TSG showed markedly hair regrowth. TUNEL+ cells were also reduced in mice with TSG. These changes were accompanied with inhibition of Fas, p53, Bax, Active Caspase-3, and Procaspase-9 activities. These results demonstrated that TSG exerts great hair regrowth effect on hair loss, which was probably mediated by inhibition of p53, Fas, and Bax induced apoptosis.
PMID: 29808162 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 30, 2018 Category: Research Authors: Chen L, Duan H, Xie F, Gao Z, Wu X, Chen F, Wu W Tags: Biomed Res Int Source Type: research
Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
Miao Zhang, Longfei Lin, Hongmei Lin, Changhai Qu, Lei Yan, Jian Ni (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 25, 2018 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 23, Pages 1115: Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
g-Zhen Zhao
In commercial herbal markets, Polygoni Multiflori Radix (PMR, the tuberous roots of Polygonum multiflorum Thunb.), a commonly-used Chinese medicinal material, is divided into different grades based on morphological features of size and weight. While more weight and larger size command a higher price, there is no scientific data confirming that the more expensive roots are in fact of better quality. To assess the inherent quality of various grades and of various tissues in PMR and to find reliable morphological indicators of quality, a method combining laser microdissection (LMD) and ultra-performance liquid...
Source: Molecules - May 8, 2018 Category: Chemistry Authors: Li Liang Jun Xu Zhi-Tao Liang Xiao-Ping Dong Hu-Biao Chen Zhong-Zhen Zhao Tags: Article Source Type: research
Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
Yue Liu, Qi Wang, Jianbo Yang, Xiaohan Guo, Wenxi Liu, Shuangcheng Ma, Shaoping Li (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 16, 2018 Category: Drugs & Pharmacology Source Type: research
Protective effects of Polygonum multiflorum on ischemic stroke rat model analysed by 1H NMR metabolic profiling
This study aims to explore the protective effect of HSW on ischemic stroke rat model and to elucidate the underlying mechanisms. The mortality rate, neurological deficit, cerebral infarct size, histopathology, immunohistochemistry, biochemical parameters, quantitative real-time polymerase chain reaction and western blotting were used to access the treatment effects of HSW on ischemic stroke. Proton nuclear magnetic resonance (1H NMR) based metabolomics analysis disclosed that HSW could relieve stroke rats suffering from the ischemia/reperfusion injury by ameliorating the disturbed energy and amino acids metabolisms, allevi...
Source: Journal of Pharmaceutical and Biomedical Analysis - April 4, 2018 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 23, Pages 571: In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4 ′-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum
In this study, the anti-osteoarthritis (OA) effects of THSG were explored using in vitro and in vivo models. THSG inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production and inducible NO synthase (iNOS) and cyclooxygenase-2 expressions by lipopolysaccharide-stimulated RAW 264.7 cells. On the other hand, THSG inhibited PGE2 production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1β-stimulated primary rat chondrocytes. Through a mono-iodoacetate-induced rat OA model assay, THSG reduced paw edema and improved the weight-bearing distribution. Therefore, THSG has anti-inflammatory activity and...
Source: Molecules - March 3, 2018 Category: Chemistry Authors: Po-Wei Tsai Yi-Hui Lee Lih-Geeng Chen Chia-Jung Lee Ching-Chiung Wang Tags: Article Source Type: research
Structure characterization of two functional polysaccharides from Polygonum multiflorum and its immunomodulatory.
Abstract
Two purified polysaccharides named WPMP-1 and WPMP-2 were obtained from Polygonum multiflorum with an average molecular weight of 2.04 kDa and 92.13 kDa, respectively. Structural characterization revealed that WPMP-1was supposed to be a glucan composed of 1,4-linked α-d-Glcp, 1,4,6-linked α-d-Glcp, and terminal α-d-Glcp. WPMP-2 contained a complex branched structre formed by 1,2-linked α-d-Rhap, 1,2,4-linked α-d-Rhap, 1,3,5-linked α-l-Ara, 1,5- linked α-l-Araf, terminal α-l-Araf, 1,4-linked β-d-Galp, 1,4-linked α-d-GalpA, and 4-linked α-d-GalpA. In vitro, WPMPs were of activation ef...
Source: International Journal of Biological Macromolecules - February 19, 2018 Category: Biochemistry Authors: Zhang Q, Xu Y, Lv J, Cheng M, Wu Y, Cao K, Zhang X, Mou X, Fan Q Tags: Int J Biol Macromol Source Type: research
New utilization of Polygonum multiflorum polysaccharide as macromolecular carrier of 5-fluorouracil for controlled release and immunoprotection.
Abstract
WPMP-2 is an acid polysaccharide isolated from Polygonum multiflorum, which demonstrated excellent immunomodulatory activity. In order to reduce immunosuppression of 5-fluorouracil (5-Fu), WPMP-2 was utilized as a macromolecular carrier to conjugate the 5-Fu derivatives 5-fluorouracil-1-acetic acid (5-FUAC) through ester bond. The conjugate showed controlled drug release behaviour in vitro at 37 °C in phosphate buffer (pH 7.4), and only 5-FUAC was detected in the media. The cytotoxicity test in vitro showed that the conjugate exhibited different cytotoxicity to HepG-2 and HT-29 cells. In addi...
Source: International Journal of Biological Macromolecules - February 9, 2018 Category: Biochemistry Authors: Zhang Q, Xu Y, Lv J, Cheng M, Wu Y, Cao K, Zhang X, Mou X, Fan Q Tags: Int J Biol Macromol Source Type: research
Management of IFN-beta-induced flu-like symptoms with Chinese herbal medicine in a patient with multiple sclerosis: A case report.
CONCLUSIONS: IFNβ-1a injections will damage qi and cause blood stasis in MS patients, thereby causing various side effects and weakening the body's immune system. Bu-Zhong-Yi-Qi-Tang, associated with Salvia miltiorrhiza, Ligusticum chuanxiong, Angelica dahurica and Polygonum multiflorum Thunb., is an effective prescription to ameliorate such symptoms and signs in patients with MS.
PMID: 29458918 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - February 1, 2018 Category: Complementary Medicine Authors: Lee LW, Lin HJ, Huang ST Tags: Complement Ther Med Source Type: research
Multiflorumisides A –G, Dimeric Stilbene Glucosides
with Rare Coupling Patterns from the Roots of Polygonum multiflorum
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.7b00540 (Source: Journal of Natural Products)
Source: Journal of Natural Products - January 23, 2018 Category: Biochemistry Authors: Shuo-Guo Li, Xiao-Jun Huang, Man-Mei Li, Qing Liu, Hui Liu, Ying Wang and Wen-Cai Ye Source Type: research
Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo.
Abstract
Polygonum multiflorum Thunb. has been used widely in East Asia in treatment of diseases associated with aging. However, there are many reports referred to the toxicity of P. multiflorum, especially for liver adverse reactions. The toxicity of it is caused by over dosage or by the herb itself remains unclear. The aim of this study was to study the toxicity of different extractions, components and constituents of P. multiflorum, which were assessed in zebrafish embryos. Firstly, the difference of extracting solvent to the toxicity of P. multiflorum was researched to probe the influence of usages to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2018 Category: Drugs & Pharmacology Authors: Yang JB, Li WF, Liu Y, Wang Q, Cheng XL, Wei F, Wang AG, Jin HT, Ma SC Tags: Biomed Pharmacother Source Type: research
Improvement of biosynthesis and accumulation of bioactive compounds by elicitation in adventitious root cultures of Polygonum multiflorum.
We examined the effects of abiotic (methyl jasmonate [MeJA] and salicylic acid [SA]) and biotic (yeast extract and chitosan) elicitors for improvement of bioactive compounds production on adventitious root cultures in Polygonum multiflorum. The application of yeast extract resulted in significantly (p ≤ 0.05) higher dry root biomass (9.98 g/L) and relative growth rate versus the control. Cultures treated with abiotic elicitors showed higher percentage of dry weight than the other samples. Low concentrations of all elicitors (50 μM MeJA and SA, and 50 mg/L yeast extract) improved secondary metabolite production ex...
Source: Applied Microbiology and Biotechnology - November 14, 2017 Category: Microbiology Authors: Ho TT, Lee JD, Jeong CS, Paek KY, Park SY Tags: Appl Microbiol Biotechnol Source Type: research
