Transcriptome changes in Polygonum multiflorum Thunb. roots induced by methyl jasmonate.
In this study, we used transcriptome profiling to investigate transcriptome changes in roots of P. multiflorum seedlings subjected to a 0.25 mmol/L-MeJA root-irrigation treatment. A total of 18 677 differentially expressed genes (DEGs) were induced by MeJA treatment, of which 4535 were up-regulated and 14 142 were down-regulated compared with controls. These DEGs were associated with 125 metabolic pathways. In addition to various common primary and secondary metabolic pathways, several secondary metabolic pathways related to components with significant pharmacological effects were enriched by MeJA, including arachidonic ac...
Source: J Zhejiang Univ Sci ... - December 1, 2015 Category: Science Authors: Liu HC, Wu W, Hou K, Chen JW, Zhao Z Tags: J Zhejiang Univ Sci B Source Type: research
Transcriptome changes in Polygonum multiflorum Thunb. roots induced by methyl jasmonate
In this study, we used transcriptome profiling to investigate transcriptome changes in roots of P. multiflorum seedlings subjected to a 0.25 mmol/L-MeJA root-irrigation treatment. A total of 18 677 differentially expressed genes (DEGs) were induced by MeJA treatment, of which 4535 were up-regulated and 14 142 were down-regulated compared with controls. These DEGs were associated with 125 metabolic pathways. In addition to various common primary and secondary metabolic pathways, several secondary metabolic pathways related to components with significant pharmacological effects were enriched by MeJA, including arachidonic ac...
Source: Journal of Zhejiang University. Science. B. - December 1, 2015 Category: Universities & Medical Training Source Type: research
Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise
This study tested the acute thermogenic effectiveness of a commercially available multi-ingredient product (Shred-Matrix®), containing Green Tea Extract, Yerba Maté, Guarana Seed Extract, Anhydrous caffeine, Saw palmetto, Fo-Ti, Eleuthero root, Cayenne Pepper, and Yohimbine HCI, on fatty acid oxidation (FAO), perception of hunger, mood state and rate of perceived exertion (RPE) at rest and during 30 min of submaximal exercise.
Methods:
Following institutional ethical approval, twelve healthy recreationally active participants, five females and seven males, were randomized to perform two separate experimental ergometry c...
Source: Journal of the International Society of Sports Nutrition - November 25, 2015 Category: Sports Medicine Authors: Ahmad AlkhatibMarcos SeijoEneko LarumbeFernando Naclerio Source Type: research
Discrimination and Proper Use of Polygoni Multiflori Radix, Cynanchi Wilfordii Radix, and Cynanchi Auriculati Radix in Korea: A Descriptive Review.
Authors: Lee BJ, Lee K
Abstract
Polygoni Multiflori Radix (PMR), Cynanchi Wilfordii Radix (CWR), and Cynanchi Auriculati Radix (CAR) are very popular herbal medicines in Traditional Korean Medicine, Traditional Chinese Medicine, and Kampo Medicine. However, the plant origins, efficacies, and traditional uses of these herbal medicines differ. In Korea, PMR is called Ha Su O (He Shou Wu in China), and CWR is called Baek Ha Su O or Baek Su O (Bai Shou Wu in China). Baek Su O refers to CWR in Korea and CAR in China. CAR has not been used as a traditional herbal medicine, and it cannot be legally used as a food...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum
In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evi...
Source: Frontiers of Medicine - October 12, 2015 Category: Journals (General) Source Type: research
In vivo screening of traditional medicinal plants for neuroprotective activity against Aβ42 cytotoxicity by using Drosophila models of Alzheimer's disease.
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive neuronal loss with amyloid β-peptide (Aβ) plaques. Despite several drugs currently used to treat AD, their beneficial effects on AD progress remains under debate. Here, we established a rapid in vivo screening system using Drosophila AD models to assess the neuroprotective activities of medicinal plants that have been used in traditional Chinese medicine. Among 23 medicinal plants tested, the extracts from five plants, Coriandrum sativum, Nardostachys jatamansi, Polygonum multiflorum (P. multiflo...
Source: Biological and Pharmaceutical Bulletin - October 10, 2015 Category: Drugs & Pharmacology Authors: Liu QF, Lee JH, Kim YM, Lee S, Hong YK, Hwang S, Oh Y, Lee K, Yun HS, Lee IS, Jeon S, Chin YW, Koo BS, Cho KS Tags: Biol Pharm Bull Source Type: research
Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum.
Authors: Li Y, Han M, Lin P, He Y, Yu J, Zhao R
Abstract
Polygonum multiflorum Radix (PMR) has long history in hair growth promotion and hair coloring in clinical applications. However, several crucial problems in its clinic usage and mechanisms are still unsolved or lack scientific evidences. In this research, C57BL/6J mice were used to investigate hair growth promotion activity and possible mechanism of PMR and Polygonum multiflorum Radix Preparata (PMRP). Hair growth promotion activities were investigated by hair length, hair covered skin ratio, the number of follicles, and hair color. Regulation effect...
Source: Evidence-based Complementary and Alternative Medicine - August 23, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Tetrahydroxystilbene Glucoside Improves Neurotrophic Factors Release in Cultured Astroglia.
In this study, rat primary astroglia cultures were applied to investigate TSG-mediated neurotrophic effects. The protein levels and production of glial cell-line derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in astroglia and the culture medium were determined by western blotting assay and ELISA, respectively. Results indicated that TSG increased the production of neurotrophic factors in a concentration-dependent manner. At different time points of TSG treatment, the BDNF and NGF production in the culture medium was increased 48 h after treatment, while GDNF secre...
Source: CNS and Neurological Disorders Drug Targets - August 20, 2015 Category: Drugs & Pharmacology Authors: Lin F, Zhou Y, Shi W, Wan Y, Zhang Z, Zhang F Tags: CNS Neurol Disord Drug Targets Source Type: research
Rhein: A Review of Pharmacological Activities.
Authors: Zhou YX, Xia W, Yue W, Peng C, Rahman K, Zhang H
Abstract
Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid) is a lipophilic anthraquinone extensively found in medicinal herbs, such as Rheum palmatum L., Cassia tora L., Polygonum multiflorum Thunb., and Aloe barbadensis Miller, which have been used medicinally in China for more than 1,000 years. Its biological activities related to human health are being explored actively. Emerging evidence suggests that rhein has many pharmacological effects, including hepatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicr...
Source: Evidence-based Complementary and Alternative Medicine - July 19, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia
Conclusions:
Our results suggest that PMC-12 mainly exerted protective effects on hippocampal neurons through suppression of Ca
2+
-related ROS accumulation and regulation of signaling pathways of p38 MAPK and PI3K associated with mature BDNF expression and CREB phosphorylation and subsequently enhanced spatial memory. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 30, 2015 Category: Complementary Medicine Authors: Sung AhnYu KimHa KimYoung ChoiJae LeeCheol KimJin BaekHwa ShinByung Choi Source Type: research
A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry
This study sought to analyze the toxic components of PM using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), and their hepatotoxicity in L02 human liver cells. Toxicity was evaluated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) leakage, and liver enzyme secretion (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) assays. Furthermore, UPLC-Q-TOF/MS, Progenesis QI, and Makerlynx XS software analyses were used to differentiate extracts and analyze the toxic components. The order of toxicity was ...
Source: Journal of Hazardous Materials - June 30, 2015 Category: Environmental Health Source Type: research
Beneficial Effects of Polygonum multiflorum on Hippocampal Neuronal Cells and Mouse Focal Cerebral Ischemia.
Abstract
Beneficial effects of the water extract of Polygonum multiflorum (WEPM) and their mechanisms were investigated in HT22 hippocampal cells and hippocampus of middle cerebral artery occlusion (MCAO) mice. In HT22 cells against glutamate-induced oxidative stress, pretreatment with WEPM resulted in significantly reduced apoptotic neuronal death. Pretreatment with WEPM resulted in the suppression of ROS accumulation in connection with cellular Ca (2+) level after exposure to glutamate. Treatment with glutamate alone led to suppressed protein level of mature brain-derived neurotrophic factor (BDNF) and p...
Source: The American Journal of Chinese Medicine - June 28, 2015 Category: Complementary Medicine Authors: Ahn SM, Kim YR, Kim HN, Shin HK, Choi BT Tags: Am J Chin Med Source Type: research
PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid β-Induced Cognitive Deficits through Modulation of Neuroinflammation.
Authors: Park MY, Jung YS, Park JH, Choi YW, Lee J, Kim CM, Baek JU, Choi BT, Shin HK
Abstract
PMC-12 is a prescription used in traditional Korean medicine that consists of a mixture of four herbal medicines, Polygonum multiflorum, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, which have been reported to have various pharmacological effects on age-related neurological diseases. In the present study, we investigated whether PMC-12 improves cognitive deficits associated with decreased neuroinflammation in an amyloid-β-(Aβ-) induced mouse model and exerts the antineuroinflammatory effects ...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan
Conclusion Xue-Fu-Zhu-Yu-Tang is the most frequently prescribed formula and is typically prescribed with Shan Zha, Dan Shen, and He Shou Wu for patients with hyperlipidemia. Clinical trials are warranted in future research to investigate the effects of the CHPs in terms of safety and efficacy and in particular to evaluate potential interactions with conventional treatments. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - April 22, 2015 Category: Drugs & Pharmacology Source Type: research
Effect of sample preparation on components and liver toxicity of Polygonum multiflorum
In this study, the effect of sample preparation on components and liver toxicity of different extracts from P. multiflorum were determined. Hepatoxic components were discovered based on biomembrane extraction. Comparative chemistry and toxicology between ethanol and water extracts were also performed. The results showed that ethanol extract had much stronger hepatotoxicity, the content of emodin-8-O-β-d-glucopyranoside, physcion-8-O-β-d-glucopyranoside, emodin and physcion was significantly higher in ethanol extract than in water extract, while the human hepatocytes extraction showed that 2,3,5,4′-tetrahydroxystilbene-...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 28, 2015 Category: Drugs & Pharmacology Source Type: research
