ATP-sensitive potassium channel subunits in the neuroinflammation: novel drug targets in neurodegenerative disorders.
Abstract Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-dependent ion channels, and metabolically regulated potassium channels including ATP-sensitive potassium channels (KATP). KATP channels are hetero-multimeric complexes of sulfonylureas receptors (SUR1, SUR2A or SUR2B) and the pore-forming subunits (Kir6.1 and Kir6.2) likewise expressed in the pre-post synapsis of neurons and inflammatory cells, thereby affecting their proliferation and activity. KATP channels are involved in amyloid-β (Aβ)-induced pathology, therefore emerging as therapeutic targets against Alzheimer'...
Source: CNS and Neurological Disorders Drug Targets - January 18, 2021 Category: Drugs & Pharmacology Authors: Maqoud F, Scala R, Hoxha M, Zappacosta B, Tricarico D Tags: CNS Neurol Disord Drug Targets Source Type: research

Experimental Rodent Models of Vascular Dementia: A Systematic Review.
Abstract Vascular dementia (VaD) occurs due to cerebrovascular insufficiency, which leads to decreased blood circulation to the brain, thereby resulting in mental disabilities. The main causes of vascular cognitive impairment (VCI) are severe hypoperfusion, stroke, hypertension, large vessel disease (cortical), small vessel disease (subcortical VaD), strategic infarct, hemorrhage (microbleed), cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and cerebral amyloid angiopathy (CAA),which leads to decreased cerebrovascular perfusion. Many metabolic disorders such as...
Source: CNS and Neurological Disorders Drug Targets - January 8, 2021 Category: Drugs & Pharmacology Authors: Tiwari N, Upadhyay J, Ansari MN, Raza SS, Ahmad W, Ansari MA Tags: CNS Neurol Disord Drug Targets Source Type: research

Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-induced Allodynia and Hyperalgesia in a Mouse Model of Inflammatory Pain.
CONCLUSION: These results suggest that antinociceptive effects of α7 nAChR PAM are associated with downregulation of hippocampal BDNF and p-NKCC1 and upregulation of KCC2 in a mouse model of inflammatory pain. PMID: 33380307 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Authors: Abbas M, Alzarea S, Papke RL, Rahman S Tags: CNS Neurol Disord Drug Targets Source Type: research

Thoughts of death, depression, and guilt in a healthcare worker who infected her husband with SARS-CoV-2: A case report.
We report the case of a 61-year-old HCW who likely infected her husband with SARS-CoV-2, leading to his death. We assessed the depressive and anxious symptoms that the patient experienced after the death of her husband, which were characterized by a deep sense of guilt, psychological pain, and thoughts of death. PMID: 33357200 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - December 23, 2020 Category: Drugs & Pharmacology Authors: Berardelli I, Vaia A, Pompili M Tags: CNS Neurol Disord Drug Targets Source Type: research

Ethanolamine: A Potential Promoiety with Additional Effects in the Brain.
Abstract Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement across the blood-brain barrier. This improvement in the ability to target drugs to the brain may also mean that in the process ethanolamine concentrations in the brain are increased enough for ethanolamine to exert its own neurological ac-tions. Ethanolamine and its associated products have various positive functions ranging from cell signaling to molecular storage, and...
Source: CNS and Neurological Disorders Drug Targets - December 11, 2020 Category: Drugs & Pharmacology Authors: Gwanyanya A, Godsmark CN, Kelly-Laubscher R Tags: CNS Neurol Disord Drug Targets Source Type: research

Liver-Brain Axis in Sporadic Alzheimer's Disease: Role of Ten Signature Genes in a Mouse model.
CONCLUSION: We strongly advocate that prolonged consumption of junk food is a major culprit in brain related disorders like Alzheimer's disease and propose that receptors for brain diseases lie outside the brain and aiming them for drug discovery and design may be beneficial in future clinical studies. This study also discusses the connection between NAFLD (nonalcoholic fatty liver disease) and sAD (sporadic Alzheimer's disease) owing to liver-brain axis. PMID: 33297922 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - December 8, 2020 Category: Drugs & Pharmacology Authors: Jakhmola-Mani R, Islam A, Katare DP Tags: CNS Neurol Disord Drug Targets Source Type: research

Emergence of sexual dreams and emission following deep transcranial magnetic stimulation over the medial and cingulate cortices.
PMID: 33297923 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - December 8, 2020 Category: Drugs & Pharmacology Authors: Shen Y, Cao X, Zeng NN, Wang Y, Zhang H, Zangen A, Yuan TF Tags: CNS Neurol Disord Drug Targets Source Type: research

Autophagic Dysfunction in Dementia: Scope for Development of Potential Remedies.
Abstract Dementia is a diverse category of a chronic and progressive disorder, which is commonly associated with loss of memory, difficulty in judgment, impaired language, cognitive impairment, and various other symptoms that affects a person's daily routine life and social life. Dementia affects about 50 million people around the globe. Dementia exists in varied forms and is associated with various neurodegenerative disorders. Alzheimer's disease dementia is the most common form which accords for about 60% cases. Abnormal agglomeration of proteins in the brain has been linked to the pathogenesis of dementia. Auto...
Source: CNS and Neurological Disorders Drug Targets - December 8, 2020 Category: Drugs & Pharmacology Authors: Kumar B, Pandey M, Mishra AK, Sharma A, Fayaz F, Pottoo FH Tags: CNS Neurol Disord Drug Targets Source Type: research

Acute phenobarbital poisoning for the management of seizures in new-borns and children; A systematic literature review.
CONCLUSION: PB therapy for the management of seizures in newborns and children might be associated with poisoning. Alt-hough supportive and symptomatic treatments are available for PB overdose, it should be administered with caution, using drug monitoring to avoid toxicity. PMID: 33290203 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - December 7, 2020 Category: Drugs & Pharmacology Authors: Ghorani-Azam A, Balali-Mood M, Riahi-Zanjani B, Darchini-Maragheh E, Sadegh M Tags: CNS Neurol Disord Drug Targets Source Type: research

Importance of Zebrafish as an efficient research model for the screening of novel therapeutics in neurological disorders.
Abstract In the previous years of research, the use of animal model becomes very common for the screening of novel drugs. Animal model represents the complex problems of humans into simplest forms which can be extended further to include the experimental procedure. The most successful models in neuroscience, rats and mice, undoubtedly considered as one of the best models to understand the psychology of mammalian brain and its associated functions involved in various behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals especially fish as mo...
Source: CNS and Neurological Disorders Drug Targets - December 7, 2020 Category: Drugs & Pharmacology Authors: Saluja D, Jhanji R, Kaushal S, Verma B, Sharma N, Singh R, Agrawal S, Yadav M, Kumar A, Singh C, Singh A Tags: CNS Neurol Disord Drug Targets Source Type: research

Restless Leg syndrome in patients with liver cirrhosis! Its frequency, severity, and correlation.
Abstract BACKGROUND: Restless leg syndrome (RLS) has been recognized as a typical extra appearance among patients with cirrhosis of liver. RLS prevalence in liver cirrhosis further augments the worsening quality of life which has already been compromised with the disease related complications of cirrhosis itself. AIMS: The study was aimed to determine the frequency and severity of Restless Leg Syndrome (RLS) among patients with cirrhosis of liver and to correlate its severity with severity of cirrhosis. MATERIALS AND METHODS: This prospective cross-sectional study was carried out at Ruth K.M. Pfau Civil ...
Source: CNS and Neurological Disorders Drug Targets - December 7, 2020 Category: Drugs & Pharmacology Authors: Naqvi IH, Ahmed J, Salim M, Ubaid M, Malik F, Afzal R, Ashrafi MM, Khan MAA Tags: CNS Neurol Disord Drug Targets Source Type: research

COVID-19 Outbreak: Neurological Manifestations beyond Cough and Fever.
Abstract COVID-19 outbreak is one of the most disastrous respiratory diseases (after the 1918 influenza outbreak) spreading in the community. So far, it has killed 7,37,417 number of individuals. High variability in the viral genome and its greater ability to spread in the human community is badly affecting the comorbid individuals. Although infected individuals are mainly possessing respiratory issues, neurological manifestations in these individuals cannot be overlooked. The literature search is based on the recent development in the concerned field. We searched databases like PubMed, Google Scholar, and Science...
Source: CNS and Neurological Disorders Drug Targets - November 20, 2020 Category: Drugs & Pharmacology Authors: Kumar S, Dwivedi D, Chopra M Tags: CNS Neurol Disord Drug Targets Source Type: research

Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to The Essential Oil Components.
CONCLUSION: The essential oil component of A. conyzoides L is a potential novel substance for use as anti-neuropathic pain. PMID: 33222681 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - November 20, 2020 Category: Drugs & Pharmacology Authors: Sukmawan YP, Anggadiredja K, Adnyana IK Tags: CNS Neurol Disord Drug Targets Source Type: research

Novel Targets Explored in Treatment of Alcohol Dependence induced Withdrawal Syndrome.
Abstract Alcohol withdrawal syndrome (AWS) is characterized as termination of chronic and sustained alcohol use that leads to severe symptoms of distress or loss of daily functions when alcohol consumption is diminished or stopped. It is a debilitating manifestation of alcohol dependence and responds poorly to the available clinical therapies. Globally alcohol drinking is continuously increasing all across the world. It causes 3.3 million deaths every year (5.9% of all deaths), and 5.1% of the global burden of disease. Alcohol Withdrawal syndrome led to various changes in brain neurotransmitters sys-tem such as GA...
Source: CNS and Neurological Disorders Drug Targets - November 18, 2020 Category: Drugs & Pharmacology Authors: Gupta A, Khan H, Kaur A, Singh TG Tags: CNS Neurol Disord Drug Targets Source Type: research

Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis.
Abstract Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review ex-plores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia ac-tivation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopa-thy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies. PMID: 33...
Source: CNS and Neurological Disorders Drug Targets - November 17, 2020 Category: Drugs & Pharmacology Authors: Zhao L, Gao Y, Guo S, Lu X, Yu S, Ge ZZ, Zhu HD, Li Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Histone Deacetylase Inhibitors Prevented the Development of Morphine Tolerance by Decreasing IL6 Production and Upregulating μ-Opioid Receptors.
CONCLUSION: Results indicated that HDAC inhibitors were involved in the prevention of morphine tolerance in normal mice by inhibiting pro-inflammatory marker production and by increasing the sensitivity of neurons towards morphine in producing an analgesic effect in morphine tolerated mice. PMID: 33191889 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - November 12, 2020 Category: Drugs & Pharmacology Authors: Jindal S, Kumar N, Shah AA, Shah A, Gourishetti K, Rao CM Tags: CNS Neurol Disord Drug Targets Source Type: research

Detection, Treatment Planning, and Genetic Predisposition of Bruxism: A Systematic Mapping Process and Network Visualization Technique.
In conclusion, it has been found that bruxism altogether has sleep, neurological, dental and genetic disorder components and is a complex phenomenon. This study has also mentioned the future direction and research gap so far conducted on bruxism and has also tried to provide goals for the upcoming research to be accomplished in a more significant and scientific manner. PMID: 33172381 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - November 10, 2020 Category: Drugs & Pharmacology Authors: Belal Bin Heyat M, Akhtar F, Khan MH, Ullah N, Gul I, Khan H, Lai D Tags: CNS Neurol Disord Drug Targets Source Type: research

Neuroblastoma and stem cell therapy - An updated review.
CONCLUSIONS: Stem cells are a group of multipotent undifferentiated cells that are capable of producing all cells in a particular tissue, organ, or organism. They have an endogenous self-renewal property. This property is tightly modulated for the normal homeostasis within the body. However, the failure of this process leads to carcinogenesis, including NBM. As these properties are modulated via various intrinsic as well as extrinsic pathways, the arrest of these pathways via various drugs may help in controlling various carcinomas, including NBM. Recently, stem cells used diagnosis and therapy is widely for the NBM treatm...
Source: CNS and Neurological Disorders Drug Targets - November 1, 2020 Category: Drugs & Pharmacology Authors: Gupta MK, Mallepalli S, Damu AG, Vadde R Tags: CNS Neurol Disord Drug Targets Source Type: research

Nanomedicinal Strategies as Emerging Therapeutic Avenues for the Management Cerebral Ischemia.
Abstract Amongst the various diseases on global scale, the second leading cause of mortality and morbidity is ischemic stroke due to the unavailability of an effective therapy. With the growing occurrence and its related health risks along with the absence of effective therapeutics, the ischemic stroke demands the continued and intensive research to explore the effective and safe therapeutics. These therapies may positively affect the numerous pathways associated with neuroprotection thus, extending the advantages to a larger population of stroke patients. Several preclinical studies employing neuroprotectants hav...
Source: CNS and Neurological Disorders Drug Targets - November 1, 2020 Category: Drugs & Pharmacology Authors: Fatima S, Quadri SN, Parveen S, Beg S, Barkat MA, Samim M, Abdin MZ, Ahmad FJ Tags: CNS Neurol Disord Drug Targets Source Type: research

Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications.
CONCLUSION: Taken together, our data demonstrated that the interaction of CRMP2 and spastin is required for neurite outgrowth and branch formation and their interaction is not regulated by their phosphorylation. PMID: 33109053 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 26, 2020 Category: Drugs & Pharmacology Authors: Li S, Zhang J, Zhang J, Li J, Cheng L, Chen L, Cha C, Guo G Tags: CNS Neurol Disord Drug Targets Source Type: research

Exploring the various aspects of Brain Derived Neurotropic Factor (BDNF) in Diabetes Mellitus.
CONCLUSION: The current article reviews the intricate role of BDNF in Type 2 DM (T2DM) by involving platelet reactivity and its association with these selected inflammatory platelet activator mediators. Besides, certain adipocytokines, such as adiponectin and leptin, are also involved in the metabolism of glucose during diabetes, which has been clearly proven by recent experimental studies and thus relating BDNF with adipocytokines. It is also involved in modulation of secretion of various neurotransmitters, peptides and hormones like gherin, leptin and insulin, suggesting its association with T2DM. Thus, based on various ...
Source: CNS and Neurological Disorders Drug Targets - October 14, 2020 Category: Drugs & Pharmacology Authors: Sharma E, Behl T, Mehta V, Kumar A, Setia D, Uddin MS, Zengin G, Arora S Tags: CNS Neurol Disord Drug Targets Source Type: research

Melatonin alleviates pyroptosis of retinal neurons following acute intraocular hypertension.
CONCLUSION: MT treatment might be considered a new strategy for protecting retinal neurons against pyroptosis following acute HIOP injury. PMID: 33045971 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 12, 2020 Category: Drugs & Pharmacology Authors: Yu Z, Yanxia H, Limin G, Yun Z, Mingxuan Z, Fuyao X, Cheng T, Jufang H, Dan C Tags: CNS Neurol Disord Drug Targets Source Type: research

Herbal drug interaction: Mechanistic details through the pharmacokinetic portfolio.
CONCLUSION: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices in regard to patient safety. The expanding comprehension of HDPKI will make more attention to the potential interactions. PMID: 33032517 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 8, 2020 Category: Drugs & Pharmacology Authors: Ahmed S, Khan H, Mirzaei H, Hasan MM, Eddouks M, Daglia M Tags: CNS Neurol Disord Drug Targets Source Type: research

MCC950 reduces neuronal apoptosis in spinal cord injury in mice.
CONCLUSION: These results reveal that MCC950 exerts neuroprotective effects by reducing neuronal apoptosis, preserving the survival of the remaining neurons, attenuating the severity of the damage, and promoting the recovery of motor function after SCI. PMID: 33023460 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 5, 2020 Category: Drugs & Pharmacology Authors: He N, Zheng X, He T, Shen G, Wang K, Hu J, Zheng M, Ding Y, Song X, Zhong J, Chen YY, Wang LL, Shen Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Cardiac Biomarkers in Stroke, Alzheimer's Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations.
Abstract Conventionally cardiac biomarkers are recognized as an essential tool to investigate the presence or progression of various cardiovascular diseases. However, in recent years data from several clinical trials have successfully sorted out the utility of cardiac biomarkers in diseases that are not primarily regarded as "cardiac diseases," especially neurological diseases. Results of freshly published trials have endorsed the use of cardiac biomarkers in various forms of stroke and dementia, including Alzheimer's disease. Alzheimer's disease is also one of the other CNS conditions where measuring ca...
Source: CNS and Neurological Disorders Drug Targets - October 5, 2020 Category: Drugs & Pharmacology Authors: Khan S, Kamal MA Tags: CNS Neurol Disord Drug Targets Source Type: research

The AMPAR antagonist perampanel regulates neuronal necroptosis via Akt/GSK3 β signaling after acute traumatic injury in cortical neurons.
CONCLUSION: Our present data suggest that necroptosis plays a key role in the pathogenesis of neuronal death after TNI, and that perampanel might have therapeutic potential for patients with traumatic brain injury (TBI). PMID: 33001018 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Authors: Chen T, Yang LK, Zhu J, Hang CH, Wang YH Tags: CNS Neurol Disord Drug Targets Source Type: research

Role of Forkhead transcription factors of the O class (FoxO) in development and progression of Alzheimer's disease.
Abstract In the central nervous system (CNS), a specific loss of focal neurons leads to mental and neurological disorders like dementia, Alzheimer's disease (AD), Huntington's disease, Parkinson's disease, etc. AD is a neurological degenerative disorder, which isprogressive and irreversible in nature and is the widely recognized reason for dementia in the geriatric populace. It affects 10% of people above the age of 65andis the fourth driving reason for death in the United States.Numerous evidence suggests that the neuronal compartment is not the only genesis of AD, but transcription factorsalso hold significant i...
Source: CNS and Neurological Disorders Drug Targets - September 29, 2020 Category: Drugs & Pharmacology Authors: Goswami S, Goyal RK, Mumtaz SM, Tonk RK, Gupta R, Pottoo FH Tags: CNS Neurol Disord Drug Targets Source Type: research

Biomarker validation of a new case definition of menstrual cycleassociated syndrome (MCAS) Opinion Paper.
In conclusion, we propose, to a) use the MCAS diagnosis as an indicant of menstrual cycle-related symptoms; and b) examine the associations of the time series in the DRSP and its subdomains and those in biomarkers including distributed lag models. Aberrations in the uterine-chemokine-brain-axis underpin the pathophysiology of MCAS whereby suboptimal pre-ovulatory follicular development coupled with a relative corpus luteum insufficiency may drive increased chemokine production, lowered antioxidant defenses, neuro-oxidative stress pathways, and increased bacterial translocation. As such, we have delineated new drug targets ...
Source: CNS and Neurological Disorders Drug Targets - September 28, 2020 Category: Drugs & Pharmacology Authors: Roomruangwong C, Maes M Tags: CNS Neurol Disord Drug Targets Source Type: research

Atorvastatin Prevent the Neuron Loss in the Hippocampal Dentate Gyrus Region through its Anti-oxidant and Anti-apoptotic Activities.
In this study, we hypothesized that atorvastatin could prevent the neurons lost in the hippocampal dentate gyrus region after transient global ischemia/reperfusion (I/R) through its anti-oxidant and anti-apoptotic activities. METHOD: Twenty-four male Wistar rats 12-13 weeks old and weighing 250-300 g, were divided randomly into four groups: control, I/R, vehicle (I/R treated with NaCl) and experiment (I/R treated with atorvastatin, 10 mg/kg) and rats were sacrificed 96 hours after I/R. Quantitative expression of genes (caspase 8, p53, bax, bcl2, cytochrome c) was studied. The MDA level, SOD, CAT, and GPx activities we...
Source: CNS and Neurological Disorders Drug Targets - September 21, 2020 Category: Drugs & Pharmacology Authors: Yadollah-Damavandi S, Sharifi ZN, Arani HZ, Jangholi E, Karimi A, Parsa Y, Movassaghi S Tags: CNS Neurol Disord Drug Targets Source Type: research

Targeting microglial polarization to improve TBI outcomes.
Abstract Traumatic brain injury (TBI) is still the worldwide leading cause of mortality and morbidity in young adults. Improved safety measures and advances in critical care have improved chances of surviving a TBI, however, numerous secondary mechanisms contribute to the injury in the weeks and months that follow TBI. The past 4 decades of research have addressed many of the metabolic impairments sufficient to mitigate mortality, however, an enduring secondary mechanism, i.e. neuroinflammation, has been intractable to current therapy. Neuroinflammation is particularly difficult to target with pharmacological agen...
Source: CNS and Neurological Disorders Drug Targets - September 17, 2020 Category: Drugs & Pharmacology Authors: Nathalie M, Polineni Sp, Chin Cn, Fawcett D, Clervius H, Liz Maria QS, Legnay F, Rego L, Mahavadi Ak, Jermakowicz Wj, Lee Sw-T, Yokobori S, Gajavelli S Tags: CNS Neurol Disord Drug Targets Source Type: research

Nanotechnology: its application in treating Neurodegenerative diseases.
Abstract Neurodegenerative diseases including Alzheimer's, Parkinson's and Huntington disease are have serious concern due to its effect on the quality of life of affected persons. Neurodegenerative diseases have some limitations for both diagnostic as well as at treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly in solving the problem. There are several treatment strategies for the neurodegenerative diseases, but their limitations are the entry into the due to the presence of the blood-brain barrier (BBB). The present review highlights the application of ...
Source: CNS and Neurological Disorders Drug Targets - September 15, 2020 Category: Drugs & Pharmacology Authors: Naz F, Siddique YH Tags: CNS Neurol Disord Drug Targets Source Type: research

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.
igo R Abstract The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window ...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Orellana-Urzúa S, Claps G, Rodrigo R Tags: CNS Neurol Disord Drug Targets Source Type: research

An Insight on Molecular Mechanisms & Novel Therapeutic Approaches in Epileptogenesis.
An Insight on Molecular Mechanisms & Novel Therapeutic Approaches in Epileptogenesis. CNS Neurol Disord Drug Targets. 2020 Sep 10;: Authors: Singh S, Singh TG, Rehni AK Abstract Epilepsy is a second most common neurological disease with abnormal neural activity involving activation of various intracellular signalling transduction mechanisms. The molecular and system biology mechanisms responsible for epileptogenesis are not well defined or understood. Neuroinflammation, neurodegeneration & Epigenetic modification elicit epileptogensis. The excessive neuronal activities in brain are associated ...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Singh S, Singh TG, Rehni AK Tags: CNS Neurol Disord Drug Targets Source Type: research

MicroRNA-targeted signaling pathways in the Autism spectrum disorder: implications for early detection and targeted therapy.
CONCLUSION: This study showed that the identified miRNAs may be involved in ASD-related pathways and may be considered as a new diagnostic tool and provide potential targets for the treatment of ASD. PMID: 32895046 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 6, 2020 Category: Drugs & Pharmacology Authors: Alizadeh R, Bahmanpoor Z, Jalali-Qomi S, Amiri M, Afkhami H, Khaledi M, Moosavi R, Akouchekian M Tags: CNS Neurol Disord Drug Targets Source Type: research

Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogues with Potent Cholinesterase Inhibition.
CONCLUSION: These compounds have potential to serve as a dual binding site inhibitor and might provide a useful template for the development of new anti- Alzheimer's disease agents. PMID: 32888280 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 4, 2020 Category: Drugs & Pharmacology Authors: Biscussi B, Richmond V, Baier CJ, Mañez PA, Murray AP Tags: CNS Neurol Disord Drug Targets Source Type: research

Association Between Heart Rate Variability and Parkinson's Disease: A Meta-Analysis.
CONCLUSION: Our meta-analysis found that PD is associated with reduced HRV values, which indicates that both sympathetic and vagal activity are decreased. Patients in the early stage of PD have sympathetic autonomic nerve dysfunction with only minor damage to sympathetic activity. PMID: 32888281 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 4, 2020 Category: Drugs & Pharmacology Authors: Li Y, Wang J, Li X, Jing W, Omorodion I, Liu L Tags: CNS Neurol Disord Drug Targets Source Type: research

Glia and Glial Growth Factors as New Therapeutic Targets in Neuropsychiatric Disorders.
PMID: 32888282 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 4, 2020 Category: Drugs & Pharmacology Authors: Hashioka S Tags: CNS Neurol Disord Drug Targets Source Type: research

Protein interaction studies for understanding the tremor pathway in Parkinson's disease.
Conclusion: In the current study it is predicted that ADORA2A and DRD1/DRD2 are equally contributing to the progression of disease by inhibiting the activity of adenylyl cyclase and thereby increases the permeability of the blood brain barrier causing an influx of neurotransmitters and together they alter the level of dopamine in the brain which eventually leads to tremor. PMID: 32888283 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - September 4, 2020 Category: Drugs & Pharmacology Authors: Dogra N, Mani RJ, Katare DP Tags: CNS Neurol Disord Drug Targets Source Type: research

Decoding the Inter-relationship between Sleep Disorders and Alzheimer's disease Pathogenesis.
Abstract Alzheimer's disease (AD), characterized by abnormally phosphorylated tau, paired helical filaments (PHFs), neurofibrillary tangles (NFTs), deregulated mammalian target of rapamycin (mTOR), Aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. Therefore, we have reviewed the literature and have tried to decode the existence of positive feedback, reciprocal and a bidirectional relationship allying between sleep disturbances and AD. Much light has been thrown on the role of tau pathology and amyloid pathology in sleep pathology and its association with AD patho...
Source: CNS and Neurological Disorders Drug Targets - September 2, 2020 Category: Drugs & Pharmacology Authors: Mueed Z, Rai PK, Kamal MA, Poddar NK Tags: CNS Neurol Disord Drug Targets Source Type: research

Deciphering the role of aberrant protein post translational modification in the pathology of neurodegeneration.
Abstract Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), are characterized by progressive neuronal dysfunction and death. Current studies have established detrimental modifications in brain protein function as well as structure which stimulate their aggregation, misfolding and deposition in and around the neurons, as an important hallmark of neurodegenerative disorders. Posttranslational modification (PTM) of proteins including phosphorylation, acetylation, glycosylation, palmitoylation, SUMOylation, and u...
Source: CNS and Neurological Disorders Drug Targets - September 2, 2020 Category: Drugs & Pharmacology Authors: Shafi S, Singh A, Gupta P, Chawla PA, Fayaz F, Sharma A, Pottoo FH Tags: CNS Neurol Disord Drug Targets Source Type: research

Minocycline inhibits mTOR signaling activation and alleviates behavioral deficits in the Wistar rats with acute ischemia stroke.
This study is to aim at the effects of minocycline on the mTOR signaling in the AIS process and further discover the underlying mechanisms of minocycline involved in the following change of mTOR signaling-autophagy. METHODS: Cerebral ischemia/reperfusion (CIR) rat animal models were established with the transient suture occlusion into middle cerebral artery. Minocycline (50mg/kg) was given by intragastric administration. The Morris water maze was used to test the cognitive function of animals. Immunohisto chemistry and immuno fluorescence were introduced for testing the lev-els of synaptophysin and PSD-95. Western blo...
Source: CNS and Neurological Disorders Drug Targets - August 30, 2020 Category: Drugs & Pharmacology Authors: Wang S, Wang C, Wang L, Cai Z Tags: CNS Neurol Disord Drug Targets Source Type: research

A Systematic Review on the Role of Arachidonic Acid Pathway in Multiple Sclerosis.
CONCLUSIONS: All studies reported the beneficial effects of COX and LOX inhibitors in MS. The hybrid compounds, such as COX-2 inhibitors/TP antagonists and 5-LOX inhibitors can be an innovative approach for multiple sclerosis treatment. Future work in MS should shed light in synthesizing new compounds targeting arachidonic acid pathway. PMID: 32842948 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 24, 2020 Category: Drugs & Pharmacology Authors: Hoxha M, Spahiu E, Prendi E, Zappacosta B Tags: CNS Neurol Disord Drug Targets Source Type: research

Efficacy and tolerability of Lacosamide for focal epileptic patients: Study from epilepsy clinic in Makkah.
CONCLUSION: Lacosamide is an effective well tolerate drug for patients with focal epilepsy. PMID: 32814542 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 17, 2020 Category: Drugs & Pharmacology Authors: Alkhotani A, Abualula H, Almatrafi Y, Ghoniem S, Alkhotani A Tags: CNS Neurol Disord Drug Targets Source Type: research

A Novel Approach to Refractory Epilepsy by Targeting Pgp peripherally and centrally: Therapeutic targets and Future perspectives.
Abstract Refractory epilepsy is a type of epilepsy involving seizures uncontrolled by first or second-line anticonvulsant drugs at a regular therapeutic dose. Despite considerable growth in epileptic pharmacotherapy, one-third of the patients are resistant to current therapies. In this, the mechanisms responsible for resistant epilepsy are either increased expulsion of an-tiepileptic drugs (AEDs) by multidrug resistance (MDR) transporters from the epileptogenic tissue or reduced sensitivity of drug in epileptogenic brain tissue. The difficulty to treat refractory epilepsy is because of drug resistance due to cellu...
Source: CNS and Neurological Disorders Drug Targets - August 17, 2020 Category: Drugs & Pharmacology Authors: Langeh U, Chawla P, Gupta GD, Singh S Tags: CNS Neurol Disord Drug Targets Source Type: research

Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer's Disease: A Recent Update.
Abstract Alzheimer Association Report (2019) stated that the 6th primary cause of death in the USA is Alzheimer's disease (AD) which leads to behaviour and cognitive impairment. Nearly 5.8 million peoples of all ages in the USA have suffered from this disease, including 5.6 million elderly populations. The statistics of the progression of this disease is similar to the global scenario. Still, the treatment of AD is limited to a few conventional oral drugs which often fail to deliver the adequate amount of drug in the brain. The reduction in the therapeutic efficacy of anti-AD drug is due to poor solubility, existe...
Source: CNS and Neurological Disorders Drug Targets - August 17, 2020 Category: Drugs & Pharmacology Authors: Pandey M, Choudhury H, Verma RK, Chawla V, Bhattamisra SK, Gorain B, Raja MAG, Amjad MW Tags: CNS Neurol Disord Drug Targets Source Type: research

1,3,5-Pyrazoline Derivatives in CNS disorders: Synthesis, Biological Eval-uation and Structural Insights through Molecular Docking.
CONCLUSION: The synthesized compounds were found to possess great potential in decreasing the duration of immobility in Swiss albino mice and scavenging free radicals. These compounds may serve as new leads for further drug exploration. PMID: 32811418 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 17, 2020 Category: Drugs & Pharmacology Authors: Sharma H, Chawla PA, Bhatia R Tags: CNS Neurol Disord Drug Targets Source Type: research

Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin.
CONCLUSION: The molecular basis of selective inhibition of ALDH-2 by isoflavonoids and related compounds could be related to a more fa-vorable equilibrium relationship between enthalpic and entropic features. The results described herein expand the available knowledge re-garding the physiopathological and therapeutic mechanisms associated with drug addiction. PMID: 32811404 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 16, 2020 Category: Drugs & Pharmacology Authors: da Silva Cunha TT, de Souza FR, Murteira Pinheiro PS, de Sant'Anna CMR, Noël F, Costa França TC, Manssour Fraga CA Tags: CNS Neurol Disord Drug Targets Source Type: research

The MMP-2/TIMP-2 system in Alzheimer disease.
Abstract Alzheimer disease (AD) is the most prevalent type of dementia. Pathological changes in the AD brain include amyloid β-protein (Aβ) plaques and neurofibrillary tangles (NFTs), as well as extensive neuronal and synaptic loss. Matrix metalloproteinase-2 (MMP-2) is a neutral, zinc-dependent protease that primarily targets extracellular matrix proteins. MMP-2 activity is strictly controlled, and its dysregulation has been implicated in a variety of pathologies including AD. In this brief review, we discussed the contributions of dysregulated MMP-2 activity and an imbalanced interaction between MMP-2 ...
Source: CNS and Neurological Disorders Drug Targets - August 11, 2020 Category: Drugs & Pharmacology Authors: Wang H, Huang L, Wu L, Lan J, Feng X, Li P, Peng Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Neuroprotection of Rotenone induced Parkinsonism by Ursolic acid in PD mouse model.
CONCLUSION: Thus, our study puts forward the neuroprotective potential of UA which can be further explored for possible clinical intervention. PMID: 32787765 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 11, 2020 Category: Drugs & Pharmacology Authors: Zahra W, Rai SN, Birla H, Singh SS, Rathore AS, Dilnashin H, Singh R, Keswani C, Singh RK, Singh SP Tags: CNS Neurol Disord Drug Targets Source Type: research

The retrotransposition of L1 is involved in the reconsolidation of contextual fear memory in mice.
CONCLUSIONS: The retrotransposition of L1 participated in the reconsolidation of fear memory after the reactivation of fear memory , and with lamivudine treatment, spontaneous recovery was decreased with time after the recent and remote fear memory recall, which might provide more clues for understanding the roles of L1 in fear memory and the possible strategy for treating PTSD. PMID: 32787766 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 11, 2020 Category: Drugs & Pharmacology Authors: Zhang WJ, Huang YQ, Fu A, Chen KZ, Li SJ, Zhang Q, Zou GJ, Liu Y, Su JZ, Zhou SF, Liu JW, Li F, Bi FF, Li CQ Tags: CNS Neurol Disord Drug Targets Source Type: research