Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies
CONCLUSIONS: Based on a cumulative meta-analysis of available studies indicating an association between migraine and obesity, obesity can be appropriately considered an overall risk factor for migraine headaches. Additional high-quality original studies considering frequency, severity, and duration of headache must clarify confident evidence.PMID:34259152 | DOI:10.2174/1871527320666210713114840 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - July 14, 2021 Category: Drugs & Pharmacology Authors: Mahsa Hatami Neda Soveid Azadeh Lesani Kurosh Djafarian Sakineh Shab-Bidar Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Cellular senescence and ApoE4: their repercussions in Alzheimer's disease
CNS Neurol Disord Drug Targets. 2021 Jun 27. doi: 10.2174/1871527320666210628102721. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by progressive memory loss due to neurodegeneration that occurs mainly during aging. The accumulation of senescent cells has been related to aging. Furthermore, the expression of the variant ApoE ∈ 4 is a critical risk factor for AD. Some events that occur in senescence, such as the secretion of pro-inflammatory molecules, and metabolic and epigenetic changes, in addition to the detection of ApoE4, may accelerate the progression of AD. Here, we discuss the implica...
Source: CNS and Neurological Disorders Drug Targets - June 29, 2021 Category: Drugs & Pharmacology Authors: Angeles Tecalco-Cruz Jes ús Zepeda-Cervantes Lilia L ópez-Canovas Josu é O Ramírez-Jarquín Jos é Pedraza-Chaverrí Alfredo Briones-Herera Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Benzodiazepines and Sleep Architecture: a Systematic Review
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory, and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.PMID:34145997 | DOI:10.2174/1871527320666210618103344 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 19, 2021 Category: Drugs & Pharmacology Authors: Felipe Maraucci Ribeiro de Mendon ça Giulia Paulo Rossi Ribeiro de Mendon ça Laura Costa Souza Lucas Pequeno Galv ão Henrique Soares Paiva Cintia de Azevedo Marques P érico Julio Torales Antonio Ventriglio Jo ão Maurício Castaldelli-Maia Anderson So Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review
CNS Neurol Disord Drug Targets. 2021 Jun 2. doi: 10.2174/1871527320666210602152308. Online ahead of print.ABSTRACTAs a source of therapeutic agents, heterocyclic nitrogen-containing compounds and their derivatives are still interesting and essential. Pyrazole, a five-member heteroaromatic ring with two nitrogen atoms, has a major impact on chemical industries as well as pharmaceutical industries. Due to its wide range of biological activities against various diseases, it has been identified as a biologically important heterocyclic scaffold. The treatment of neurological disorders has always been a difficult task. Therefore...
Source: CNS and Neurological Disorders Drug Targets - June 3, 2021 Category: Drugs & Pharmacology Authors: Subham Das Saleem Akbar Bahar Ahmed Rikeshwar Prasad Dewangan Mohammad Kashif Iqubal Ashif Iqubal Pooja Chawla Faheem Hyder Pottoo Alex Joseph Source Type: research

Targeting Brain Cancer Cells by Nanorobot, a Promising Nanovehicle: New Challenges and Future Perspectives
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526154801. Online ahead of print.ABSTRACTAdvances in the field of nanotechnology and nanomedicine have resulted in the development of novel diagnosis and potential treatment for different types of diseases, including brain cancer. Nanomaterials are smaller in size, having a higher area to volume ratio, and can be conjugated with other molecules. Nanomaterials are excellent transport vehicles that can easily cross the extracellular matrix, cell membrane, and by crossing the blood-brain barrier they can deliver the drugs to the remote and inaccessible ...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Chandra Kishore Priyanka Bhadra Source Type: research

Highlighting the protective or degenerative role of AMPK activators in dementia experimental models
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160214. Online ahead of print.ABSTRACTAMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuro...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Marjan Nikbakhtzadeh Fatemeh Shaerzadeh Ghorbangol Ashabi Source Type: research

Immunotherapies for Parkinson's disease: Progression of Clinical Development
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160926. Online ahead of print.ABSTRACTParkinson's disease is a common neurodegenerative disease affecting the movement and wellbeing of most elderlies. The manifestations of Parkinson's disease often include resting tremor, stiffness, bradykinesia and muscular rigidity. The typical hallmark of Parkinson's disease is the destruction of neurons in the substantia nigra and the presence of Lewy bodies in different compartments of the central nervous system. Due to various limitations to the currently available treatments, immunotherapies have emerged ...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Jet Shee Teng Yin Yin Ooi Soi Moi Chye Anna Pick Kiong Ling Rhun Yian Koh Source Type: research

Targeting Brain Cancer Cells by Nanorobot, a Promising Nanovehicle: New Challenges and Future Perspectives
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526154801. Online ahead of print.ABSTRACTAdvances in the field of nanotechnology and nanomedicine have resulted in the development of novel diagnosis and potential treatment for different types of diseases, including brain cancer. Nanomaterials are smaller in size, having a higher area to volume ratio, and can be conjugated with other molecules. Nanomaterials are excellent transport vehicles that can easily cross the extracellular matrix, cell membrane, and by crossing the blood-brain barrier they can deliver the drugs to the remote and inaccessible ...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Chandra Kishore Priyanka Bhadra Source Type: research

Highlighting the protective or degenerative role of AMPK activators in dementia experimental models
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160214. Online ahead of print.ABSTRACTAMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuro...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Marjan Nikbakhtzadeh Fatemeh Shaerzadeh Ghorbangol Ashabi Source Type: research

Immunotherapies for Parkinson's disease: Progression of Clinical Development
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160926. Online ahead of print.ABSTRACTParkinson's disease is a common neurodegenerative disease affecting the movement and wellbeing of most elderlies. The manifestations of Parkinson's disease often include resting tremor, stiffness, bradykinesia and muscular rigidity. The typical hallmark of Parkinson's disease is the destruction of neurons in the substantia nigra and the presence of Lewy bodies in different compartments of the central nervous system. Due to various limitations to the currently available treatments, immunotherapies have emerged ...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Jet Shee Teng Yin Yin Ooi Soi Moi Chye Anna Pick Kiong Ling Rhun Yian Koh Source Type: research

Targeting Brain Cancer Cells by Nanorobot, a Promising Nanovehicle: New Challenges and Future Perspectives
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526154801. Online ahead of print.ABSTRACTAdvances in the field of nanotechnology and nanomedicine have resulted in the development of novel diagnosis and potential treatment for different types of diseases, including brain cancer. Nanomaterials are smaller in size, having a higher area to volume ratio, and can be conjugated with other molecules. Nanomaterials are excellent transport vehicles that can easily cross the extracellular matrix, cell membrane, and by crossing the blood-brain barrier they can deliver the drugs to the remote and inaccessible ...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Chandra Kishore Priyanka Bhadra Source Type: research