2,3,5,4'-Tetrahydroxy stilbene-2- Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo
Chem Biol Interact. 2022 Nov 1:110234. doi: 10.1016/j.cbi.2022.110234. Online ahead of print.ABSTRACT2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside (TSG) and emodin (EMD) are two main components of Polygonum multiflorum Thunb. (PMT). Its root is widely used as herbal medicine and supplement. However, PMT-induced liver injury has drawn increasing attention. The purpose of this study was to investigate the interaction of TSG with EMD in the aspects of enzymology, pharmacokinetics, and hepatotoxicity. Co-administration with TSG increased internal exposure of EMD, EMD-derived hepatic protein adduction, and EMD-induced live...
Source: Chemico-Biological Interactions - November 4, 2022 Category: Molecular Biology Authors: Xu Wang Lingwen Dong Guode Zhao Weiwei Li Ying Peng Jiang Zheng Source Type: research
2,3,5,4'-Tetrahydroxy stilbene-2- Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo
Chem Biol Interact. 2022 Nov 1:110234. doi: 10.1016/j.cbi.2022.110234. Online ahead of print.ABSTRACT2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside (TSG) and emodin (EMD) are two main components of Polygonum multiflorum Thunb. (PMT). Its root is widely used as herbal medicine and supplement. However, PMT-induced liver injury has drawn increasing attention. The purpose of this study was to investigate the interaction of TSG with EMD in the aspects of enzymology, pharmacokinetics, and hepatotoxicity. Co-administration with TSG increased internal exposure of EMD, EMD-derived hepatic protein adduction, and EMD-induced live...
Source: Chemico-Biological Interactions - November 4, 2022 Category: Molecular Biology Authors: Xu Wang Lingwen Dong Guode Zhao Weiwei Li Ying Peng Jiang Zheng Source Type: research
Molecules, Vol. 27, Pages 6760: Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
un
Shuangcheng Ma
In recent years, the hepatotoxicity of Polygoni Multiflora Radix (PMR) has attracted increased research interest. Some studies suggest that anthraquinone may be the main hepatotoxic component. Most of the relevant studies have focused on the mononuclear anthraquinone component rather than binuclear anthraquinones. The hepatotoxicity of dinuclear anthraquinone (dianthrone) was investigated in a cell-based model. Next, a method for the determination of six free and total dianthonones in PMR and PMR Praeparata (PMRP) was established using ultra-high-performance liquid chromatography triple quadrupole m...
Source: Molecules - October 10, 2022 Category: Chemistry Authors: Huiyu Gao Jianbo Yang Xueting Wang Yunfei Song Xianlong Cheng Feng Wei Ying Wang Donglin Gu Hua Sun Shuangcheng Ma Tags: Article Source Type: research
2,3,5,4 ′-tetrahydroxystilbene-2-O-β-D-glucoside ameliorates bleomycin-induced pulmonary fibrosis via regulating pro-fibrotic signaling pathways
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) is the main active ingredient extracted from Polygonum multiflorum Thunb. (PMT), which has been reported to possess extensive pharmacological properties. Nevertheless, the exact role of THSG in pulmonary fibrosis has not been demonstrated yet. The main purpose of this study was to investigate the protective effect of THSG against bleomycin (BLM)-induced lung fibrosis in a murine model, and explore the underlying mechanisms of THSG in transforming growth factor-beta 1 (TGF-β1)-induced fibrogenesis using MRC-5 human lung fibroblast cells. We found that THSG significa...
Source: Frontiers in Pharmacology - October 4, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 6284: Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics
Huibin Lin
Steaming is a characteristic pharmaceutical skill in Traditional Chinese Medicine (TCM). Polygonum multiflorum radix (PM) and its steamed products have been used in Asia for centuries. Raw Polygonum multiflorum radix (RPM) is commonly used to promote defecation but can exert toxicity, especially in liver injury. However, RPM can be made converted into Polygoni multiflori radix praeparata (PMP) by steaming; this is considered a good method to reduce defecation and liver injury caused by PM in Asia. The chemical constituents of TCM are the key to its action. We systematically analyzed the effect of steaming...
Source: Molecules - September 23, 2022 Category: Chemistry Authors: Xiaolei Du Lili Xu Zhe Zhang Yang Wang Huifen Li Weiliang Cui Huibin Lin Tags: Article Source Type: research
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice
In this study, the potential of GSE on macrophage polarization was explored. GSE significantly down-regulated the levels of M1 macrophage biomarkers (Cd32a, Cd80 and Cd86) while increased the levels of M2 indicators (Cd163, Mrc1 and Socs1), showing its potential to inhibit LPS-induced M1 polarization of macrophages. This ability has close a link to its effect on metabolic reprogramming of macrophage. GSE shunted nitric oxide (NO) production from arginine by up-regulation of arginase and down-regulation of inducible nitric oxide synthase, thus attenuated the inhibition of NO on OXPHOS. LPS created three breakpoints in the t...
Source: International Immunopharmacology - September 18, 2022 Category: Allergy & Immunology Authors: Wenlong Zhao Di Xu Wei Hong Lin Zhang Qinyan Wu Mingzhe Gao Junsong Wang Source Type: research
Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice
In this study, the potential of GSE on macrophage polarization was explored. GSE significantly down-regulated the levels of M1 macrophage biomarkers (Cd32a, Cd80 and Cd86) while increased the levels of M2 indicators (Cd163, Mrc1 and Socs1), showing its potential to inhibit LPS-induced M1 polarization of macrophages. This ability has close a link to its effect on metabolic reprogramming of macrophage. GSE shunted nitric oxide (NO) production from arginine by up-regulation of arginase and down-regulation of inducible nitric oxide synthase, thus attenuated the inhibition of NO on OXPHOS. LPS created three breakpoints in the t...
Source: International Immunopharmacology - September 18, 2022 Category: Allergy & Immunology Authors: Wenlong Zhao Di Xu Wei Hong Lin Zhang Qinyan Wu Mingzhe Gao Junsong Wang Source Type: research
2,3,5,4'-Tetrahydroxystilbene-2- < em > O < /em > - β-D-Glucoside improves female ovarian aging
In conclusion, THSG can delay aging-related menopause, and the antioxidant properties of THSG may make it suitable for preventing aging-induced infertility.PMID:36111333 | PMC:PMC9469098 | DOI:10.3389/fcell.2022.862045 (Source: Cancer Control)
Source: Cancer Control - September 16, 2022 Category: Cancer & Oncology Authors: Hung-Yun Lin Yung-Ning Yang Yi-Fong Chen Tung-Yung Huang Dana R Crawford Hui-Yu Chuang Yu-Tang Chin Hung-Ru Chu Zi-Lin Li Ya-Jung Shih Yi-Ru Chen Yu-Chen S H Yang Yih Ho Paul J Davis Jacqueline Whang-Peng Kuan Wang Source Type: research
A stepwise strategy integrating metabolomics and pseudotargeted spectrum –effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum
In this study, we developed a stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to illuminate the potential hepatotoxic components in PM. First, 112 components were tentatively identified using ultraperformance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UPLC-Q-TOF-MS). Second, based on the theory of toxicity attenuation after processing, we combined the UPLC-Q-TOF-MS method and plant metabolomics to screen out the reduced differential components in PM between raw and processed PM. Third, the proposed pseudotargeted MS of 16 differential components was estab...
Source: Frontiers in Pharmacology - August 26, 2022 Category: Drugs & Pharmacology Source Type: research
Assessing potential liver injury induced by < em > Polygonum multiflorum < /em > using potential biomarkers via targeted sphingolipidomics
CONCLUSIONS: Three potential biomarkers and one criterion for potential liver injury caused by PM that may be more sensitive than ALT and AST were found.PMID:35949191 | DOI:10.1080/13880209.2022.2099908 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - August 11, 2022 Category: Drugs & Pharmacology Authors: Zhixin Jia Lirong Liu Jie Liu Cong Fang Mingxia Pan Jingxuan Zhang Yueting Li Zhong Xian Hongbin Xiao Source Type: research
Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway
In conclusion, our results are the first to highlight the beneficial role and relevant mechanisms of ISL in EMO-induced liver injury and provide novel insight into its application.PMID:35944824 | DOI:10.1016/j.cbpc.2022.109430 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 9, 2022 Category: Biochemistry Authors: Boran Ni Yi Liu Xue Gao Mengru Cai Jing Fu Xingbin Yin Jian Ni Xiaoxv Dong Source Type: research
Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway
In conclusion, our results are the first to highlight the beneficial role and relevant mechanisms of ISL in EMO-induced liver injury and provide novel insight into its application.PMID:35944824 | DOI:10.1016/j.cbpc.2022.109430 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 9, 2022 Category: Biochemistry Authors: Boran Ni Yi Liu Xue Gao Mengru Cai Jing Fu Xingbin Yin Jian Ni Xiaoxv Dong Source Type: research
Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway
In conclusion, our results are the first to highlight the beneficial role and relevant mechanisms of ISL in EMO-induced liver injury and provide novel insight into its application.PMID:35944824 | DOI:10.1016/j.cbpc.2022.109430 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 9, 2022 Category: Biochemistry Authors: Boran Ni Yi Liu Xue Gao Mengru Cai Jing Fu Xingbin Yin Jian Ni Xiaoxv Dong Source Type: research
Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo
CONCLUSIONS: Our results validated that the metabolism of emodin to 5-hydroxyemodin by CYP1A played an important role in the hepatocellular toxicity of emodin and provided evidence that CYP1A1 and AhR could be used to predict and validate patient-specific liver injury of PMT or other herbs containing emodin.PMID:35934134 | DOI:10.1016/j.cbi.2022.110089 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - August 7, 2022 Category: Molecular Biology Authors: Meixi Wang Zuqi Zhang Panpan Ruan Guangchen Zhang Chengrong Xiao Yuguang Wang Yue Gao Source Type: research
