Molecules, Vol. 27, Pages 6760: Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity

Molecules, Vol. 27, Pages 6760: Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
Molecules doi: 10.3390/molecules27196760
Authors:
Huiyu Gao
Jianbo Yang
Xueting Wang
Yunfei Song
Xianlong Cheng
Feng Wei
Ying Wang
Donglin Gu
Hua Sun
Shuangcheng Ma

In recent years, the hepatotoxicity of Polygoni Multiflora Radix (PMR) has attracted increased research interest. Some studies suggest that anthraquinone may be the main hepatotoxic component. Most of the relevant studies have focused on the mononuclear anthraquinone component rather than binuclear anthraquinones. The hepatotoxicity of dinuclear anthraquinone (dianthrone) was investigated in a cell-based model. Next, a method for the determination of six free and total dianthonones in PMR and PMR Praeparata (PMRP) was established using ultra-high-performance liquid chromatography triple quadrupole mass spectrometry (UPLC-QQQ-MS/MS), which was then used to analyze the collected samples. The data show that four binuclear anthraquinone compounds were hepatotoxic and may be potential toxicity indicators for the safety evaluation of PMR and PMRP. Herein, we provide a theoretical basis for the improvement of PMRP quality standards.

Source: Molecules - October 10, 2022 Category: Chemistry Authors: Huiyu Gao Jianbo Yang Xueting Wang Yunfei Song Xianlong Cheng Feng Wei Ying Wang Donglin Gu Hua Sun Shuangcheng Ma Tags: Article Source Type: research