The Anti-hyperlipidemia Effects of Raw Polygonum multiflorum Extract in Vivo.
In this study, the effects and relevant mechanisms of lipid-regulation by raw Polygonum multiflorum (RPM) were investigated. The results indicated that the basal plasma lipids, such as low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), were significantly decreased in RPM treatment groups compared with the model group, especially in the RPM high dose group. The key enzymes involved in lipid metabolism, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) in plasma were generally reduced after oral administration, which was consi...
Source: Biological and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Xian Z, Liu Y, Xu W, Duan F, Guo Z, Xiao H Tags: Biol Pharm Bull Source Type: research
Stilbene Glucoside, a Putative Sleep Promoting Constituent from Polygonum multiflorum Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase.
Abstract
Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented. Electroencephalogram (EEG) and electromyogram (EMG) electrodes were implanted to deter...
Source: Chemical and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Wei Q, Ta G, He W, Wang W, Wu Q Tags: Chem Pharm Bull (Tokyo) Source Type: research
Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
Yun-Xia Li, Xiao-Hong Gong, Mei-Chen Liu, Cheng Peng, Peng Li, Yi-Tao Wang (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 1, 2017 Category: Drugs & Pharmacology Source Type: research
Application of iTRAQ-Based Quantitative Proteomics Approach to Identify Deregulated Proteins Associated with Liver Toxicity Induced by Polygonum Multiflorum in Rats
Conclusion: This iTRAQ proteomics study revealed that the hepatotoxicity induced by PM is primarily related to the oxidative phosphorylation pathways. NADH dehydrogenase family proteins andSlc16a2 could be potential biomarkers of hepatotoxicity resulting from PM.Cell Physiol Biochem 2017;43:2102 –2116 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 25, 2017 Category: Cytology Source Type: research
2,3,5,4 ‑tetrahydroxy diphenylethylene‑2‑O‑glucoside inhibits the adhesion and invasion of A549 human lung cancer cells.
In conclusion, THSG effectively suppressed the adhesion and invasion of human lung cancer cells potentially by inhibiting the expression of adhesion and invasion‑related genes.
PMID: 28990072 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity.
In conclusion, TSG, as a major component of P. multiflorum Thunb. exhibited an osteogenic promoting activity in MSCs and in zebrafish. The results provided scientific evidence to support the potential use of TSG for protecting the bone in degenerative diseases, such as OP.
PMID: 28966672 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - October 4, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research
Therapeutic applications of resveratrol and its derivatives on periodontitis
Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time‐consuming. Recently, herbal medicines have been considered for use in treating inflammation‐related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti‐inflammatory properties and other medical benefits. Here, we highlight the importance of resveratr...
Source: Annals of the New York Academy of Sciences - August 30, 2017 Category: Science Authors: Yu ‐Tang Chin, Guei‐Yun Cheng, Ya‐Jung Shih, Chi‐Yu Lin, Shan‐Jen Lin, Hsuan‐Yu Lai, Jacqueline Whang‐Peng, Hsien‐Chung Chiu, Sheng‐Yang Lee, Earl Fu, Heng‐Yuan Tang, Hung‐Yun Lin, Leroy F Liu Tags: REVIEW Source Type: research
Application of HPLC-LTQ Orbitrap MS for metabolic profiles of Polygonum multiflora extract in rats.
Abstract
The root of Polygonum multiflora (PM) is an important Chinese herbal medicine for treatment of various diseases. Extensive pharmacological studies have been conducted and demonstrated that it shows a wide range of bioactivities. Meanwhile, considerable amount of hepatotoxicity cases due to oral administration of PM has been reported and attracted great attention. However, The limited knowledge regarding the metabolism of PM restricts the deeper studies on pharmacological/toxic mechanism and therapeutic material basis. The present study was aimed to develop a high-performance liquid chromatography ...
Source: Biomedical Chromatography : BMC - August 17, 2017 Category: Biomedical Science Authors: Zhang J, Wang T, Ren Z, Gong L, Huang J, Bai J, Qiu X, Xu W Tags: Biomed Chromatogr Source Type: research
Erratum: "Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma".
PMID: 28760043 [PubMed - in process] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - August 3, 2017 Category: Complementary Medicine Authors: Lee CC, Lee YL, Wang CN, Tsai HC, Chiu CL, Liu LF, Lin HY, Wu R Tags: Am J Chin Med Source Type: research
Polygonumnolides A1-B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb.
Abstract
Seven new dianthrone glycosides, named polygonumnolides A1-B3 (1-7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1-4 showed moderate cytotoxicity.
PMID: 28681348 [PubMed - as supplied by publisher] (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - July 5, 2017 Category: Drugs & Pharmacology Authors: Yang J, Yan Z, Ren J, Dai Z, Ma S, Wang A, Su Y Tags: Arch Pharm Res Source Type: research
Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR- γ.
In this study, we investigated the molecular basis of PM-induced liver injury in a rat model of IDILI based on a non-hepatotoxic dose of LPS. SD rats were orally administered 3 potentially hepatotoxic compounds of PM: cis-stilbene glucoside (cis-SG, 50 mg/kg), trans-SG (50 mg/kg) or emodin (5 mg/kg), followed by injection of LPS (2.8 mg/kg, iv). Serum and liver histology were evaluated 7 h after LPS injection. Among the 3 compounds tested, cis-SG, but not emodin or trans-SG, induced severe liver injury in rats when combined with LPS. The levels of AST and ALT in plasma and inflammatory cytokines in both plasma and liver ti...
Source: Acta Pharmacologica Sinica - June 26, 2017 Category: Drugs & Pharmacology Authors: Meng YK, Li CY, Li RY, He LZ, Cui HR, Yin P, Zhang CE, Li PY, Sang XX, Wang Y, Niu M, Zhang YM, Guo YM, Sun R, Wang JB, Bai ZF, Xiao XH Tags: Acta Pharmacol Sin Source Type: research
Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1.
The objective of this study is to investigate the relationship between the hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root of Polygonum multiflorum Thunb., He Shou Wu) and the activity of CYP1A2 or CYP2E1 in the rat liver. Levels of rat serum transaminases ALT and AST were not altered but the activity of CYP1A2 or CYP2E1 in the rat liver was significantly inhibited after oral administration of aqueous extract of PMR under the experimental dosage. However, levels of ALT and AST were significantly increased and the activity of CYP1A2 or CYP2E1 was significantly decreased after injection of specific inhibitor f...
Source: Evidence-based Complementary and Alternative Medicine - June 20, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
Longfei Lin, Hui Li, Hongmei Lin, Miao Zhang, Changhai Qu, Lei Yan, Xingbin Yin, Jian Ni (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 20, 2017 Category: Drugs & Pharmacology Source Type: research
Sequential extraction and separation using ionic liquids for stilbene glycoside and anthraquinones in Polygonum multiflorum
Publication date: September 2017 Source:Journal of Molecular Liquids, Volume 241 Author(s): Xueting Feng, Hang Song, Bing Dong, Yang Yang, Shun Yao In recent years, ionic liquids (ILs) have received more attentions in green extraction and separation process as a kind of novel environment-friendly solvent, and their application in the field of natural products needs to be extended. In this paper, a new method of the sequential extraction for stilbene glycoside and anthraquinones from Polygonum multiflorum was developed for the first time and different ionic liquids was used and compared. It was found two benzothiazol...
Source: Journal of Molecular Liquids - June 7, 2017 Category: Molecular Biology Source Type: research
