Multiflorumisides HK, stilbene glucosides isolated from Polygonum multiflorum and their in vitro PTP1B inhibitory activities.
Abstract
A phytochemical study on a 70% EtOH extract of dried roots of Polygonum multiflorum resulted in the isolation of four undescribed stilbene glucosides, namely multiflorumisides HK (1-4). The structures of the natural products were elucidated by 1D and 2D nuclear magnetic resonance (NMR) as well as mass spectroscopy analyses. Among them, multiflorumiside J (3) and multiflorumiside K (4) belong to rare tetramer stilbene glucosides. Moreover, the in vitro inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) were evaluated and the putative biosynthetic pathway was proposed. Notably, co...
Source: Fitoterapia - August 19, 2020 Category: Biochemistry Authors: Yang JB, Ye F, Tian JY, Song YF, Gao HY, Liu Y, Wang Q, Wang Y, Ma SC, Cheng XL, Wei F Tags: Fitoterapia Source Type: research
Polygonum multiflorum Thunb. Extract Stimulates Melanogenesis by Induction of COX2 Expression through the Activation of p38 MAPK in B16F10 Mouse Melanoma Cells.
We examined the effects of PME on cell viability, cellular melanin content, and tyrosinase activity in B16F10 cells. The melanogenic mechanism of PME was explored using signaling inhibitors and examining the expression of melanogenic genes and signaling molecules by western blot and RT-qPCR analyses. PME did not exhibit any cytotoxicity in B16F10 cells compared to that in control cells. PME treatment significantly increased melanin production and tyrosinase activity. In addition, PME induced the expression of cyclooxygenase-2 (COX2) as well as that of melanogenic genes, such as microphthalmia-associated transcription facto...
Source: Evidence-based Complementary and Alternative Medicine - July 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology
Publication date: 28 October 2020Source: Journal of Ethnopharmacology, Volume 261Author(s): Xinyan Xue, Yunyun Quan, Lihong Gong, Xiaohong Gong, Yunxia Li (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 28, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance.
Abstract
Total polysaccharide from Polygonum multiflorum (PS) and 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could relieve high-fat and high-sugar diet (HF-HSD) induced rats' insulin resistance (IR) by gut microbiota and host regulation. We found that PS and TSG significantly reversed the increase of fasting blood glucose and the decrease of glucose tolerance in HF-HSD induced IR rats. PS and TSG effectively reversed the imbalance of Firmicutes/Bacteroides caused by an HF-HSD, and significantly reduced the relative abundance of Proteobacteria. It also affected the functional genes of gut micro...
Source: International Journal of Biological Macromolecules - July 16, 2020 Category: Biochemistry Authors: Bi Q, Gu W, Meng F, Yang X, Zeng L, Liang L, Yang M, Zhang T, Yu J Tags: Int J Biol Macromol Source Type: research
Molecules, Vol. 25, Pages 3070: Otoprotective Effect of 2,3,4 ′,5-Tetrahydroxystilbene-2-O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells
Molecules, Vol. 25, Pages 3070: Otoprotective Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells
Molecules doi: 10.3390/molecules25133070
Authors:
Yu-Hsuan Wen
Jia-Ni Lin
Rong-Shuan Wu
Szu-Hui Yu
Chuan-Jen Hsu
Guo-Fang Tseng
Hung-Pin Wu
Excessive levels of reactive oxygen species (ROS) lead to mitochondrial damage and apoptotic cell death in gentamicin-induced ototoxicity. 2,3,4’,5-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), a bioactive constituent, isolated from Polygonum multiflorum Thunb., exhibits...
Source: Molecules - July 5, 2020 Category: Chemistry Authors: Yu-Hsuan Wen Jia-Ni Lin Rong-Shuan Wu Szu-Hui Yu Chuan-Jen Hsu Guo-Fang Tseng Hung-Pin Wu Tags: Article Source Type: research
New phenolic constituents obtained from Polygonum multiflorum
Publication date: Available online 2 July 2020Source: Chinese Herbal MedicinesAuthor(s): Jian-bo Yang, Hua Sun, Jie Ma, Yun-fei Song, Yue Liu, Qi Wang, Shuang-cheng Ma, Xian-long Cheng, Feng Wei (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - July 2, 2020 Category: Complementary Medicine Source Type: research
High effective extraction of selected anthraquinones from Polygonum multiflorum using ionic liquids with ultrasonic assistance
Publication date: 15 September 2020Source: Journal of Molecular Liquids, Volume 314Author(s): Ke Yuan, Shiyu Chen, Xuemei Chen, Shun Yao, Xuejiao Wang, Hang Song, Minghui Zhu (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - July 1, 2020 Category: Molecular Biology Source Type: research
2,3,5,4 ′-tetrahydroxystilbene-2-O-β-D-glucoside induces autophagy of liver by activating PI3K/Akt and Erk pathway in prediabetic rats
2,3,5,4 ′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is an active compound derived from Polygonum multiflorum Thunb., a Chinese Taoist herbal medicine, which exerts lipid lowering, anti-cancer, anti-aging, anti-... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 8, 2020 Category: Complementary Medicine Authors: Xuanbin Wang, Jing Zeng, Xiao Wang, Ju Li, Jin Chen, Ning Wang, Miao Zhang, Yibin Feng and Huailan Guo Tags: Research article Source Type: research
Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells
Dermal papilla cells (DPCs) play a key role in hair growth among the various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as anagen to telogen transition and play a p... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 12, 2020 Category: Complementary Medicine Authors: Jae Young Shin, Yun-Ho Choi, Jaeyoon Kim, Se Young Park, You Jin Nam, So Young Lee, Jeong Hoon Jeon, Mu Hyun Jin and Sanghwa Lee Tags: Research article Source Type: research
Molecules, Vol. 25, Pages 2278: Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties
umar B Kunnumakkara
According to the World Health Organization (WHO), cancer is the second-highest cause of mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the disease, poor prognosis, cost of conventional therapies, and associated side-effects add more burden to patients, post-diagnosis. Therefore, the search for alternatives for the treatment of cancer that are safe, multi-targeted, effective, and cost-effective has compelled us to go back to ancient systems of medicine. Natural herbs and plant formulations are laden with a variety of phytochemicals. One such compound ...
Source: Molecules - May 11, 2020 Category: Chemistry Authors: Sahu Henamayee Kishore Banik Bethsebie Lalduhsaki Sailo Bano Shabnam Choudhary Harsha Satti Srilakshmi Naidu VGM Seung Ho Baek Kwang Seok Ahn Ajaikumar B Kunnumakkara Tags: Review Source Type: research
Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells.
Authors: Kim DU, Chung JY, Jin SC, Kim MH, Komakech R, Shim KS, Kim YG, Yang WM, Kang Y
Abstract
This present study evaluated the effects of processed P. multiflorum on osteogenesis using Sarcoma osteogenic (SaOS-2) cell lines and osteoclastogenesis of bone marrow-derived macrophage cells (BMM) and to elucidate differences in effect on the expression of bone-related proteins between commercially sold P. multiflorum and patented, in vitro-propagated Korea Institute of Oriental Medicine (KIOM) P. multiflorum. Raw P. multiflorum and P. multiflorum that were stir-baked and steamed in black bean juice were comp...
Source: Evidence-based Complementary and Alternative Medicine - May 10, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
2,3,5,4'-tetrahydroxystilbence-2-O- β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish.
2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish.
Biomed Pharmacother. 2020 May 05;127:110138
Authors: Wang C, Hu NH, Yu LY, Gong LH, Dai XY, Peng C, Li YX
Abstract
With the improvement of people's living standards and the change of dietary habits, Non-alcoholic fatty liver disease (NAFLD) has gradually become one of the liver diseases that endanger human health around the world. However, there are no particularly effective drugs for NAFLD in the current market. Therefore, new drug candidate...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2020 Category: Drugs & Pharmacology Authors: Wang C, Hu NH, Yu LY, Gong LH, Dai XY, Peng C, Li YX Tags: Biomed Pharmacother Source Type: research
PARP1 might enhance the therapeutic effect of tetrahydroxystilbene glucoside in traumatic brain injury via inhibition of Ras/JNK signalling pathway.
In this study, we firstly detected the oxidative stress response related molecules in serum samples of TBI patients and a TBI mice model, and found that oxidative stress response was activated after TBI, and TSG would reduce this effect. We further noticed that inflammation related molecules presented a similar trend with oxidative stress response related molecules. These results indicated that inflammatory response and oxidative stress processes were both activated after TBI, and reduced after TSG treatment. We further detected that the apoptosis related proteins and anti-oxidative proteins were increased after TSG treatm...
Source: Folia Neuropathologica - April 29, 2020 Category: Pathology Authors: Cao Y, Chen Y, Wang F, Wang Y, Long J Tags: Folia Neuropathol Source Type: research
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
In conclusion, these phenomena suggested that TSG prevented LPS/ATP and Aβ-induced inflammation via AMPK/PINK1/Parkin-dependent enhancement of mitophagy. We found the neuroprotective effect of TSG, suggesting it may be beneficial for AD prevention and treatment by suppressing the activation of inflammation.
PMID: 32353422 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 26, 2020 Category: Drugs & Pharmacology Authors: Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L Tags: Biochem Pharmacol Source Type: research
[ASAP] Water-Assisted/Water-Accelerated Photoreaction of < italic toggle="yes" > trans < /italic > -2,3,4',5-Tetrahydroxystilbene-2- < italic toggle="yes" > O < /italic > - ß- < sc > d < /sc > -glucoside from the Roots of < italic toggle="yes" > Polygonum multiflorum < /italic >
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b04922 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - April 22, 2020 Category: Food Science Authors: Ni-Man Bao, Jin Dai, Ning-Ling Liao, Wen-Feng Ying, and Rong-Hua Zhao* Source Type: research
