Multiflorumisides HK, stilbene glucosides isolated from Polygonum multiflorum and their in vitro PTP1B inhibitory activities.

Multiflorumisides HK, stilbene glucosides isolated from Polygonum multiflorum and their in vitro PTP1B inhibitory activities.
Fitoterapia. 2020 Aug 20;:104703
Authors: Yang JB, Ye F, Tian JY, Song YF, Gao HY, Liu Y, Wang Q, Wang Y, Ma SC, Cheng XL, Wei F
Abstract
A phytochemical study on a 70% EtOH extract of dried roots of Polygonum multiflorum resulted in the isolation of four undescribed stilbene glucosides, namely multiflorumisides HK (1-4). The structures of the natural products were elucidated by 1D and 2D nuclear magnetic resonance (NMR) as well as mass spectroscopy analyses. Among them, multiflorumiside J (3) and multiflorumiside K (4) belong to rare tetramer stilbene glucosides. Moreover, the in vitro inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) were evaluated and the putative biosynthetic pathway was proposed. Notably, compounds 1-4 showed the inhibitory activity against PTP1B with the IC50 values of 1.2, 1.7, 1.5 and 4.6 μm, respectively. Based on the obtained results, stilbene glucosides could be the potential PTP1B inhibitors of P. multiflorum.
PMID: 32829013 [PubMed - as supplied by publisher]

Source: Fitoterapia - August 19, 2020 Category: Biochemistry Authors: Yang JB, Ye F, Tian JY, Song YF, Gao HY, Liu Y, Wang Q, Wang Y, Ma SC, Cheng XL, Wei F Tags: Fitoterapia Source Type: research