Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis Induced Hair Loss.
In this study, we identified that p53, Caspase-3, Active Caspase-3, and Caspase-9 were obviously upregulated in the skin of human and mice with hair loss by western blot analysis. Depilated mice treated with TSG showed markedly hair regrowth. TUNEL+ cells were also reduced in mice with TSG. These changes were accompanied with inhibition of Fas, p53, Bax, Active Caspase-3, and Procaspase-9 activities. These results demonstrated that TSG exerts great hair regrowth effect on hair loss, which was probably mediated by inhibition of p53, Fas, and Bax induced apoptosis.
PMID: 29808162 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Chen L, Duan H, Xie F, Gao Z, Wu X, Chen F, Wu W Tags: Biomed Res Int Source Type: research